CN1261146C - Plaster for treating hyperplasia of mammary glands - Google Patents

Abstract

The present invention relates to a Chinese medicine plaster for treating hyperplasia of mammary glands, which is prepared from bistortae, rhizome, selfheal spike, sun plant, sea weed, kelp and other raw materials by a scientific process according to the therapeutic principle of treating internal disease externally and treating disease aiming at root causes. When used in clinic, the plaster has the functions of dispersing the liver, regulating vital energy, promoting blood circulation, dispersing blood clots, eliminating swelling, stopping pain, softening dry feces and dissipating mass. The plaster has obvious effect of treating hyperplasia of mammary glands.

Description

A kind of Chinese medicine for outer use that is used for the treatment of hyperplasia of mammary glands class disease disease

Content of the present invention belongs to the preparing technical field of pharmaceuticals, relates to a kind of Chinese medicine preparation that can be used for treating hyperplasia of mammary glands class disease disease.

Cyclomastopathy is women's commonly encountered diseases and frequently-occurring disease, and this disease has that the course of disease is long, the cause of disease is complicated and changeable, clinical cure rate is low, be easy to characteristics such as recurrence.In recent years, the diseases such as mammary gland fibroma that cyclomastopathy and mastitis cause are on the rise, and it is also more and more higher to be converted into the probability of breast carcinoma.Show in per 9～10 women of American-European developed country, just have a people to suffer from breast cancer at present according to relevant survey data.This sick pain discomfort is brought many miseries to the patient, is having a strong impact on numerous women's physical and mental health.With regard to existing therapeutic modality, doctor trained in Western medicine is advocated this disease is carried out hormone therapy or the patient is implemented excision of breast section or whole mastectomy, and the medicine of traditional treatment mastopathy mostly is Chinese patent medicine or Chinese medicine decoction, the oral medicine absorption difference, ingredient in the administration process through intestinal juice stomach acids destroy and liver metabolism, often do not reach effective blood drug concentration, influenced curative effect of medication; Furthermore Chinese medicine decoction decocts inconvenience, and bitter to the taste difficult pharynx also brings extra misery and worried to the patient.

The objective of the invention is to the problem that exists at state of the art, by excavating the abundant Chinese medicine resource of motherland, and then provide a kind of prescription science, easy to prepare, the Chinese medicine for outer use that can effectively treat hyperplasia of mammary glands class disease disease that curative effect is high.

Medicaments preparation scheme of the present invention comes from motherland's medical science about traditional determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs thoughts such as " inner disease outer treat ", " treatment must aim at the pathogenesis of disease ", and it is the designer by concentrating on studies for a long time and develop acquisition by the empirical concentrated summary of designer's clinical practice for many years many medicine and pharmacology books and folk remedy at all times.Cyclomastopathy belongs to categories such as traditional Chinese medical science stagnation of liver-QI, blood deficiency, expectorant are coagulated, incoordination between the liver and stomach, in the Chinese medicine book, early see " Huatuo's Zhongzang classic " of Han dynasty, it is called " nodules of the breast ", Song dynasty Dou Han minister in ancient times skin infection experience pandect also is referred to as " nodules of the breast ", thereafter the Qing Dynasty turns round and look at big full name of the clear surgeon of generation it " newborn painful abdominal mass ", and " Yangke Xinde Ji, Experience Gained in Treating External Diseases " " debating newborn painful abdominal mass breast expectorant breast carcinoma discusses " described very vividly to the symptom of " nodules of the breast ": " nodule in the breast is arranged; shape such as ovum ball; do not have a fever; color of the leather is constant; nuclear is growth and decline with people's susceptible to anger, this nodules of the breast." traditional Chinese medical science generally believes that cyclomastopathy is many because of depressed impairing the liver, taste are strong, can not transmitting and distributing the fluidses, accumulate into expectorant in the course of time, and expectorant coagulates channels, causes meridians and blocks, and QI and blood is retarded by silt and is sent out.Modern doctor trained in Western medicine thinks that the origin cause of formation of cyclomastopathy is because the cerebral cortex functional disorder causes the autonomic nervous dysfunction, the secreted estrogen of ovary is disequilibrium more or less, too much estrogen combines with estrogen receptor on the mammary gland glandular tube epithelial cell, cause the inside and outside potassium of cell, sodium ion permeability changes, and then make and be in hyperosmotic state in the cell, the moisture inner flow guide causes cellular edema, if things go on like this form hyperplasia, pile up in bulk, compressing local vascular, lymphatic vessel etc., cause backflow not smooth, cause distending pain of the breast, take out pain.According to above-mentioned pathogenesis pathology understanding, designer of the present invention is with pure Chinese medicine raw material Rhizoma Paridis, Rhizoma Paridis, Spica Prunellae, Herba Portulacae Grandiflorae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Olibanum, Myrrha, Folium Citri tangerinae, rhizoma sparganic, Rhizoma Curcumae, Pseudobulbus cremastrae seu pleiones, Radix Rubiae, Fructus Toosendan, Semen Strychni (processed), Rhizoma Corydalis, Flos Carthami, wine army, fry Squama Manis, Bufo siccus, Borneolum Syntheticum, Radix Notoginseng etc. are basic recipe, through science processing, make special-purpose Chinese medicine patch application, this patch has liver-smoothing, qi-regulating clinically, activating blood circulation to dissipate blood stasis, reducing swelling and alleviating pain, the effect of hard masses softening and resolving, aspect cyclomastopathy class treatment of conditions, good effect is being arranged, can significantly reduce its threat and harm health of people.

The percentage by weight constituent content that constitutes each medicine material of this Chinese medicine for outer use is: Rhizoma Paridis 3%～5%, Rhizoma Paridis 3%～5%, Spica Prunellae 1%～3%, Herba Portulacae Grandiflorae 2%～6%, Sargassum 2%～3%, Thallus Laminariae (Thallus Eckloniae) 1%～3%, Fructus Trichosanthis 2%～5%, Olibanum 10%～15%, Myrrha 10%～15%, Folium Citri tangerinae 1%～2%, rhizoma sparganic 2%～3%, Rhizoma Curcumae 1%～3%, Pseudobulbus cremastrae seu pleiones 2%～5%, Radix Rubiae 2%～4%, Fructus Toosendan 2%～4%, Semen Strychni (processed) 0.3%～0.8%, Rhizoma Corydalis 6%～10%, Flos Carthami 3%～5%, Squama Manis 2%～5% is fried, Bufo siccus 1%～3% by wine army 6%～10%, Borneolum Syntheticum 0.5%～1%, Radix Notoginseng Tabellae 5%～8%.

Pharmaceutical preparation of the present invention can be obtained by following preparation process: each medicine material that will be except that Borneolum Syntheticum with the disinfection by ultraviolet light sterilization after, again it is ground to form altogether superfine micropowder and cross 200 order sieve, with the apple vinegar infuse drug powder that adds pectin, pectin is 1～3: 10 with the preparation ratio of apple vinegar, the humidity of infuse drug powder is 50%, airtight 160～2000 hours, the ichthyol ointment that value is equated with the medicine material amount is poured in the heating kettle with after the slow fire heating fusion then, pouring the good Chinese medicine of infuse while hot in still into is also stirred, cool slightly after the stirring, adding Borneolum Syntheticum powder again stirs into and is coated with the application unguentum and packs in the bottle airtight preservation into.During clinical using, plaster is applied to is attached in the dressing on patient affected part or the corresponding acupoints.

In the system side of pharmaceutical preparation of the present invention, Rhizoma Paridis, Rhizoma Paridis, Herba Portulacae Grandiflorae, Bufo siccus have the effect of detumescence tumor; Spica Prunellae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Fructus Trichosanthis, Pseudobulbus cremastrae seu pleiones, Folium Citri tangerinae are mainly used in brokenly hard addiction, the eliminating stagnation piece; Rhizoma sparganic, Rhizoma Curcumae, Radix Rubiae, Olibanum, Myrrha, Flos Carthami, wine army, the Radix Notoginseng Tabellae removing mass detumescence of can invigorating blood circulation; Squama Manis walk to gang up network assault fortified position row dense detumescence, Fructus Toosendan, Rhizoma Corydalis, Borneolum Syntheticum, Semen Strychni (processed) then are mainly used to the promoting the circulation of QI to relieve pain of stimulating the menstrual flow.Above-mentioned all medicines close and use it, effect is concentrated one's efforts grand, furthermore suppress histamine in the mammary gland with pectin, the one-tenth of excitor substances such as 5-hydroxy tryptamine, utilize the permeability and the broken hard astriction of vinegar to bring the drug molecule dissolving into focus, utilize the oiliness feature and the drawing pus out and diminishing inflammation analgesic effect of ichthyol that medicine is not done for a long time, help the through focus of prolonged drug slow release transdermal, reach the purpose of effectively treating cyclomastopathy within a short period of time.But diseases such as the lump in breast that this medicine treating acute and chronic mastitis, cyclomastopathy, cystic hyperplasia of breast, mammary gland fibroma, intracanalicular papilloma, breast carcinoma of early stage etc. cause, mastalgia, mammary swelling.

Clinical observation and curative effect

In the pharmaceutical preparation development process of the present invention, judge that according to Ministry of Health of the People's Republic of China's " new Chinese medicine guideline " for drug effect is carried out objective checking, once clinical this medicine of use is observed 500 cases.

One, clinical symptoms (summary)

Two, administrated method: ointment 10g～12g is applied in the dressing or adhesive material of diameter 8cm size, then it is attached on patient affected part or the acupuncture point, changed dressings once in per 3～5 days, per three times is a course of treatment.

Three, efficacy determination method

1, clinical symptoms and sign disappear and detect enclosed mass through infrared ray galactophore scanning medical instrument and disappear, and the blood vessel traveling is normal or become and directly attenuate, companion or disappear without blood vessel and to be recovery from illness;

2, clinical symptoms and sign disappear, and dwindle but detect enclosed mass through infrared ray galactophore scanning medical instrument, and the blood vessel traveling normally or becomes directly or change the not obvious produce effects that is before the treatment;

3, clinical symptoms and sign alleviator are for taking a turn for the better;

4, clinical symptoms does not have the improver for invalid.

Four, observed result: 500 case patients of this group are after 1～3 course of therapy of this Chinese medicine preparation, and 335 examples of fully recovering account for 67% of total treatment case load, produce effects 80 examples account for 16% of total treatment case load, and 75 examples take a turn for the better, account for 15% of total treatment case load, the treatment total effective rate is 98%.

Claims (1)

1, a kind of Chinese medicine for outer use that is used for the treatment of hyperplasia of mammary glands class disease disease, it is characterized in that it is the coating with medicament made from following weight percentages: Rhizoma Paridis 3%～5%, Rhizoma Paridis 3%～5%, Spica Prunellae 1%～3%, Herba Portulacae Grandiflorae 2%～6%, Sargassum 2%～3%, Thallus Laminariae (Thallus Eckloniae) 1%～3%, Fructus Trichosanthis 2%～5%, Olibanum 10%～15%, Myrrha 10%～15%, Folium Citri tangerinae 1%～2%, rhizoma sparganic 2%～3%, Rhizoma Curcumae 1%～3%, Pseudobulbus cremastrae seu pleiones 2%～5%, Radix Rubiae 2%～4%, Fructus Toosendan 2%～4%, Semen Strychni (processed) 0.3%～0.8%, Rhizoma Corydalis 6%～10%, Flos Carthami 3%～5%, wine army 6%～10%, fry Squama Manis 2%～5%, Bufo siccus 1%～3%, Borneolum Syntheticum 0.5%～1%, Radix Notoginseng Tabellae 5%～8%.