CN100353995C - Pharmaceutical composition with functions of dispersing pathogenic wind, activating collaterals ,and clearing away toxin - Google Patents
Pharmaceutical composition with functions of dispersing pathogenic wind, activating collaterals ,and clearing away toxin Download PDFInfo
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- CN100353995C CN100353995C CNB031485065A CN03148506A CN100353995C CN 100353995 C CN100353995 C CN 100353995C CN B031485065 A CNB031485065 A CN B031485065A CN 03148506 A CN03148506 A CN 03148506A CN 100353995 C CN100353995 C CN 100353995C
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Abstract
The present invention discloses a medicine composition for expelling wind, activating collaterals and clearing away toxin. The composition of the present invention is prepared from mirabilite, asarum herb, medcinal evodia fruit, hemlock parsley, stiff silkworm, rhizoma corydalis, rhubarb, flos caryophyllata, cassia bark, prepared common monkshood daughter root, dark plum fruit, dahurian angelica root, ginger, heichou, baichou, borneol, Sanguis Draconis, laurocapram and polyethyleneglycol. The medical composition of the present invention has the effects of expelling wind, activating collaterals and clearing away toxin. The medical composition of the present invention has obvious effect on curing apoplexy without side effect.
Description
Invention field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of dispelling, collateral-activating antidotal pharmaceutical composition that has.
Background technology
Apoplexy belongs to modern medicine cerebrovascular category, is a kind of disease with higher incidence, case fatality rate and disability rate, be the commonly encountered diseases of middle-aged and elderly people, and age of onset has the trend of rejuvenation.In apoplexy, the ratio of cerebral infarction is higher, and according to Epidemiological study, cerebrovascular 18% is a cerebral hemorrhage, and 82% is cerebral infarction.Relevant survey data shows that the annual apoplexy sickness rate of China is 115.8/10 ten thousand, and particularly dysnoesia behind the apoplexy and limbs are disabled, and have become serious social concern and difficult medical problem; Morbidity back in the patient of first aid survival, has 73%-86% hemiplegia to occur in 1 week, and 71%-77% has moving difficulty, 47% sitting alone, and 44% has the somesthetic sensibility obstacle, and the disability rate of apoplexy is very high.It is generally acknowledged that acute stage alleviates the scope of brain tissue damage and degree is to reduce the important step of disability rate.
The clinical treatment of cerebral infarction, the traditional Chinese medical science mainly are to use square medicines such as suppressing the hyperactive liver to relieve the wind syndrome, eleminating phlegm and freeing channels, promoting flow of QI and blood, the refreshment of having one's ideas straightened out at present.Because the restriction of aspects such as route of administration is difficult to bring into play the treatment advantage in acute stage.Even some injections such as MAILUONING, QINGKAILING etc. are arranged, but because its complicated component, mechanism of action is not clear and definite as yet, and the purposiveness of clinical practice is relatively poor; Function of promoting blood circulation to disperse blood clots such as XUESHUANTONG (XUESAITONG) injection are better, but very little for causing the obstructed factor affecting of brain network stasis of blood resistance, clinical efficacy does not obtain to significantly improve.Doctor trained in Western medicine still has many insoluble problems according to the medicine and the therapeutic scheme of cerebral ischemia mechanism result of study initiative in recent years.For example, think the medicine nmda receptor antagonist (MK-801) that can stop the ischemia damage process, calcium-ion channel antagonists (nimodipine) etc. at present, can reduce the scope of ischemic pathological changes, but with making any distinction between the neurotransmission of blocking-up EAA mediation, influence some normal physiological functions, comprise and repair necessary neural plasticity, may bring adverse effect for the prognosis rehabilitation.
Technology contents
The object of the present invention is to provide a kind of dispelling, collateral-activating antidotal pharmaceutical composition that has.
The present invention is achieved through the following technical solutions: choose crude drug
Natrii Sulfas 1500-4500 weight portion Herba Asari 250-750 weight portion
Fructus Evodiae 120-370 weight portion Rhizoma Chuanxiong 120-370 weight portion
Bombyx Batryticatus 120-370 weight portion Rhizoma Corydalis 120-370 weight portion
Radix Et Rhizoma Rhei 120-370 weight portion Flos Caryophylli 120-370 weight portion
Cortex Cinnamomi 120-370 weight portion Radix Aconiti Lateralis Preparata 120-370 weight portion
Fructus Mume 120-370 weight portion Radix Angelicae Dahuricae 120-370 weight portion
Rhizoma Zingiberis Recens 120-370 weight portion Semen Pharbitidis 120-370 weight portion
Semen Pharbitidis 120-370 weight portion Borneolum Syntheticum 120-370 weight portion
Sanguis Draxonis 300-900 weight portion
Optimum ratio of the present invention is:
Natrii Sulfas 3000 weight portion Herba Asaris 500 weight portion Fructus Evodiaes 250 weight portions
Rhizoma Chuanxiong 250 weight portion Bombyx Batryticatus 250 weight portion Rhizoma Corydalis 250 weight portions
Radix Et Rhizoma Rhei 250 weight portion Flos Caryophyllis 250 weight portion Cortex Cinnamomis 250 weight portions
The Radix Aconiti Lateralis Preparata 250 weight portion Fructus Mumes 250 weight portion Radixs Angelicae Dahuricae 250 weight portions
Rhizoma Zingiberis Recens 250 weight portion Semen Pharbitidis 250 weight portion Semen Pharbitidis 250 weight portions
Borneolum Syntheticum 250 weight portion Sanguis Draxonis 600 weight portions
Also can add adjuvant laurocapram 150-450 weight portion Macrogol 2000-6000 weight portion in the present composition, preferred proportion is laurocapram 300 weight portions, the Macrogol 4000 weight portion.
Above-mentioned Chinese medicine is pulverized, crossed 80 mesh sieves, packing; Take by weighing Natrii Sulfas, Herba Asari and all the other 14 flavor Chinese medicines, mix homogeneously, sealing is stored; Take by weighing mixed dust formulation, other adds Natrii Sulfas, Sanguis Draxonis, mix homogeneously; Take by weighing Polyethylene Glycol, be dissolved into aqueously in the pot internal heating,, and stir from the fire adding laurocapram that cools; Alleged medicated powder is added in the solution, stir into and insert mould inner pressure behind the solid state gelatineous body and make circular or oval-shaped soft plaster sterilization final vacuum packing promptly.
Pharmaceutical composition of the present invention has that heat-clearing and toxic substances removing, expelling wind and removing dampness, analgesia are active, the effect of hard masses softening and resolving, clearing away lung-heat to relieve cough, consciousness-restoring and orifice-opening, and is remarkable to treating various pain (comprising cancer pain), apoplectic hemiplegia, rheumatism, rheumatoid disease, various hyperosteogeny, intervertebral disc prolapse, femur head necrosis, various diseases associated with inflammation (gastritis, cholecystitis, furuncle abscess, urinary system infection etc.), all kinds of gynaecopathia (dysmenorrhea, amenorrhea, pelvic inflammatory disease, morbid leukorrhea, cyclomastopathy etc.) and traumatic injury effect.
Pharmaceutical composition of the present invention can be made into acceptable forms clinically, as spray agent.
Pharmaceutical composition clinical treatment 2618 examples of the present invention, wherein neck lumbar vertebra hyperosteogeny, lumbago and skelalgia 2172 examples are cured 2073 examples, cure rate 96%, apoplectic hemiplegia 116 examples, cure 90 examples, cure rate 77%, rheumatism, rheumatoid, prolapse of lumbar intervertebral disc 220 examples, cure 200 examples, cure rate 98%, all the other 110 examples are furuncle abscess, phlebitis, vasculitis, curative effect is 100%.
Medicine composite for curing patient case of the present invention is listed below:
Case one: woods * *, women, 75 years old, live Chi Zhai village, Xin Dian township, Yongkang, Zhejiang Province city.The first visit date: on March 16th, 2003, patient's dizziness and tinnitus, found when March 16, slept evening that the right side limb activity is unfavorable, the slurred speech of speaking, lip is numb as formication, find right side upper and lower extremities paralysis, facial hemiparalysis morning, blood pressure 160/90mmHg, arrhythmia, 0 grade of upper right muscle tension of lower extremities, the red tongue root has thin coating, deficient and stringy pulse.Western medicine diagnose: cerebral thrombosis.Tcm diagnosis: apoplexy, apoplex involving the channels and collaterals.Card belongs to kidney unit void and declines, stirring-up of pathogenic wind in the interior resulting from deficiency, and expectorant is turbid general.Controlling should nourishing kidney-yin, put out liver-fire, the eliminating phlegm of having one's ideas straightened out.Giving dispelling, collateral-activating of the present invention detoxifcation plaster (ointment type) applies ointment or plaster and sticks Zhiyang, the gate of vitality, shen shu, bl 26 after spring, Shenque, the governor vessel scrape therapy.Changed dressings once in 48 hours, patient's upper limb muscular tension returns to 3 grades after 7 days, and muscle tension of lower extremities is recovered IV level, the life of taking care of oneself.Continue to take medicine, stick and to arrange general housework February.
Case two: should * *, women, 76 years old, live the 3rd village, sesame English street, Yongkang, Zhejiang Province city.The first visit date: on February 20th, 2003.The patient suffers from hypertension history and old-slow-bronchial tube, nephritis history.Burst right side hemiplegia, facial hemiparalysis before two months are lived the diagnosis and treatment of First People's Hospital, city with surplus effect in February.CT diagnosis: cerebral infarction.When examining, the patient is flat to crouch, and unable to move around stands up, restless asthma, accumulation and obstruction of sputum, constipation, short urination is few and red, and yellow fur is thick greasy, stringy and rolling pulse is strong, blood pressure 180/100mmHg, and the rhythm of the heart is neat, and border of cardiac dullness enlarges, two pulmonary respiration sounds are thick, being dispersed in property of audible moist rales, and wheezing sound, abdomen is flat soft, 2.5cm under the hepatomegaly rib, 3cm under the sword is in the matter, touch a tender spot (+++), right upper extremity muscular tension III level, 0 grade of right lower extremity muscular tension.Western medicine diagnose: the concurrent congestive heart failure of coronary heart disease, cerebral infarction.Tcm diagnosis: apoplexy, apoplex involving the channels and collaterals.The hot internal organs of expectorant is real, disturbs on the wind-phlegm, and hyperactivity of YANG due to deficiency of YIN, internal organs gas is not smooth.Controlling should nourishing YIN for attracting YANG, purging FU-organs purges heat.Give dispelling, collateral-activating detoxifcation cream of the present invention (ointment type) and stick Shenque, cv, the middle part of gastric cavity, Danzhong, Zhiyang, Hsinshu (acupoint), shen shu, the gate of vitality, cholecystitis, tsu san li, Tiaokou, Tai Chong, spring (two), the patient sees then that on 4th suffering from the limb muscular tension improves, can bend and stretch, asthma is calmed down, and sticks month surplusly, and the patient can descend the ground cane walking, the upper limb muscular tension increases to the IV level, after treatment February, patient's stride steadily and surely, do not tremble, life can be taken care of oneself.
Case three: old * *, the male, 62 years old, the peasant lived Shi Xia village, Xin Dian township, Yongkang city.The patient was in first visit on March 25 in 2003.The upper and lower extremities paralysis of main suit left side, numb, the companion's facial hemiparalysis of trembling, sialorrhea, vomiting 2 days.Examine in local hospital and to be cerebral infarction.Through using dehydrant, cerebral vasodilator and brain cell nutrient are not imitated.Day and night transfer my institute about 8 o'clock in 25.Have a medical check-up; Painful groan shape, T37 ℃, P76 time/minute, R20 time/minute, BP18/12kpa, 0 grade of left side upper and lower extremities muscular tension.Diagnosis: apoplexy apoplex involving the channels and collaterals.Dialectical genus Liver and kidney two void, the QI and blood retardance, the muscle arteries and veins loses supports.Control with dredging the meridian, transfer smooth QI and blood.The pin healthy side upper limb take by force life, the saturating Shaohai of Quchi, outer close close in saturating, the saturating Laogong of connected valleys, the lower limb pin is good for the saturating sp 9 of side gb 34, the saturating sp 6 of Xuanzhong, too towards saturating spring, the strong stimulation catharsis.The patient gives that dispelling, collateral-activating of the present invention detoxifcation plaster sticks neck hundred labor, Jianjing, Jian Yu, takes life by force, outer closing, lower limb paste encircle jump, Huantiao, the top four, gb 34, spring.The upper left numbness of lower limbs of patient's private prosecution takes a turn for the better after more than 10 minute, and the disappearance of trembling is emotionally stable.Giving dispelling, collateral-activating detoxifcation cream 150 gram autotherapys of the present invention again sticks.Advise and changed dressings once in 48 hours, limb functional recover is normal after 1 week, takes care of oneself.
Embodiment 1
Natrii Sulfas 3000g Herba Asari 500g Fructus Evodiae 250g Rhizoma Chuanxiong 250g
Bombyx Batryticatus 250g Rhizoma Corydalis 250g Radix Et Rhizoma Rhei 250g Flos Caryophylli 250g
Cortex Cinnamomi 250g Radix Aconiti Lateralis Preparata 250g Fructus Mume 250g Radix Angelicae Dahuricae 250g
Rhizoma Zingiberis Recens 250g Semen Pharbitidis 250g Semen Pharbitidis 250g Borneolum Syntheticum 250g
Sanguis Draxonis 600g laurocapram 300ml Macrogol 4000 g
Above-mentioned Chinese medicine is pulverized, crossed 80 mesh sieves, packing; Take by weighing Natrii Sulfas 1000g, Herba Asari 500g, all the other 14 not Chinese medicine be 250g, mix homogeneously, sealing is stored; Take by weighing mixed dust formulation 1000g, other adds Natrii Sulfas 200g, Sanguis Draxonis 60g, mix homogeneously; Take by weighing PEG400 g, be dissolved into aqueously in the pot internal heating, cooling from fire adds laurocapram 30ml, and stirs; Alleged medicated powder is added in the solution, stir into and insert mould inner pressure behind the solid state gelatineous body and make circular or oval-shaped soft plaster sterilization final vacuum packing promptly.
Embodiment 2
Natrii Sulfas 3000g Herba Asari 500g Fructus Evodiae 250g Rhizoma Chuanxiong 250g
Bombyx Batryticatus 250g Rhizoma Corydalis 250g Radix Et Rhizoma Rhei 250g Flos Caryophylli 250g
Cortex Cinnamomi 250g Radix Aconiti Lateralis Preparata 250g Fructus Mume 250g Radix Angelicae Dahuricae 250g
Rhizoma Zingiberis Recens 250g Semen Pharbitidis 250g Semen Pharbitidis 250g Borneolum Syntheticum 250g
Sanguis Draxonis 600g laurocapram 300ml Macrogol 4000 g
With said medicine routinely technology make capsule.
Claims (2)
1, a kind of have a dispelling, collateral-activating antidotal pharmaceutical composition, it is characterized in that said composition is to be made by following raw material:
Natrii Sulfas 1500-4500 weight portion Herba Asari 250-750 weight portion
Fructus Evodiae 120-370 weight portion Rhizoma Chuanxiong 120-370 weight portion
Bombyx Batryticatus 120-370 weight portion Rhizoma Corydalis 120-370 weight portion
Radix Et Rhizoma Rhei 120-370 weight portion Flos Caryophylli 120-370 weight portion
Cortex Cinnamomi 120-370 weight portion Radix Aconiti Lateralis Preparata 120-370 weight portion
Fructus Mume 120-370 weight portion Radix Angelicae Dahuricae 120-370 weight portion
Rhizoma Zingiberis Recens 120-370 weight portion Semen Pharbitidis 120-370 weight portion
Semen Pharbitidis 120-370 weight portion Borneolum Syntheticum 120-370 weight portion
Sanguis Draxonis 300-900 weight portion laurocapram 150-450 weight portion
Macrogol 2000-6000 weight portion.
2, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:
Natrii Sulfas 3000 weight portion Herba Asaris 500 weight portions
Fructus Evodiae 250 weight portion Rhizoma Chuanxiongs 250 weight portions
Bombyx Batryticatus 250 weight portion Rhizoma Corydalis 250 weight portions
Radix Et Rhizoma Rhei 250 weight portion Flos Caryophyllis 250 weight portions
Cortex Cinnamomi 250 weight portion Radix Aconiti Lateralis Preparatas 250 weight portions
The Fructus Mume 250 weight portion Radixs Angelicae Dahuricae 250 weight portions
Rhizoma Zingiberis Recens 250 weight portion Semen Pharbitidis 250 weight portions
Semen Pharbitidis 250 weight portion Borneolum Syntheticums 250 weight portions
Sanguis Draxonis 600 weight portion laurocapram 300 weight portions
The Macrogol 4000 weight portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031485065A CN100353995C (en) | 2003-07-01 | 2003-07-01 | Pharmaceutical composition with functions of dispersing pathogenic wind, activating collaterals ,and clearing away toxin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031485065A CN100353995C (en) | 2003-07-01 | 2003-07-01 | Pharmaceutical composition with functions of dispersing pathogenic wind, activating collaterals ,and clearing away toxin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1565604A CN1565604A (en) | 2005-01-19 |
| CN100353995C true CN100353995C (en) | 2007-12-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031485065A Expired - Fee Related CN100353995C (en) | 2003-07-01 | 2003-07-01 | Pharmaceutical composition with functions of dispersing pathogenic wind, activating collaterals ,and clearing away toxin |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933516A (en) * | 2014-04-15 | 2014-07-23 | 郎溪县志瑞企业信息服务有限公司 | Traditional Chinese medicine composition for treating piglet viral gastritis |
| CN105031104A (en) * | 2015-06-30 | 2015-11-11 | 广西油情米意农产品有限公司 | Wind-dispelling and collateral activating wine and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1276214A (en) * | 2000-04-14 | 2000-12-13 | 鲁雪岭 | Medicine for treating hemiplegia sequela caused by cerebrovascular accident |
| CN1337246A (en) * | 2000-08-09 | 2002-02-27 | 周垠希 | Chinese medicine for treating cerebral thrombus sequelae |
| CN1365694A (en) * | 2001-01-15 | 2002-08-28 | 杨孟君 | Nano medicine 'Huitian Zaizao' and its preparing process |
| CN1366938A (en) * | 2001-01-22 | 2002-09-04 | 杨孟君 | Nano Huishengzaizao preparation medicine and preparation method |
-
2003
- 2003-07-01 CN CNB031485065A patent/CN100353995C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1276214A (en) * | 2000-04-14 | 2000-12-13 | 鲁雪岭 | Medicine for treating hemiplegia sequela caused by cerebrovascular accident |
| CN1337246A (en) * | 2000-08-09 | 2002-02-27 | 周垠希 | Chinese medicine for treating cerebral thrombus sequelae |
| CN1365694A (en) * | 2001-01-15 | 2002-08-28 | 杨孟君 | Nano medicine 'Huitian Zaizao' and its preparing process |
| CN1366938A (en) * | 2001-01-22 | 2002-09-04 | 杨孟君 | Nano Huishengzaizao preparation medicine and preparation method |
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| Publication number | Publication date |
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| CN1565604A (en) | 2005-01-19 |
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Granted publication date: 20071212 |