CN1061854C - Medicinal preparation for treatment and prevention of gynopathy - Google Patents

Medicinal preparation for treatment and prevention of gynopathy Download PDF

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CN1061854C
CN1061854C CN93111249A CN93111249A CN1061854C CN 1061854 C CN1061854 C CN 1061854C CN 93111249 A CN93111249 A CN 93111249A CN 93111249 A CN93111249 A CN 93111249A CN 1061854 C CN1061854 C CN 1061854C
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radix
rhizoma
fubingkang
application
blood
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CN1095610A (en
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潘世庆
李炳汝
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潘世庆
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Abstract

The present invention relates to a traditional Chinese medicine preparation Fubingkang for treating and preventing gynecological affection, which comprises 20% to 80% of tonic and 20% to 80% of medicines for activating blood circulation to dissipate blood stasis, clearing heat, regulating vital energy, alleviating pain and stopping bleeding. A formulation of the present invention is a decoction, an oral liquid, a tablet, a granule or a capsule, etc. The present invention treats thousands of patients ill with gynecological affection of metrorrhagia, leukorrheal diseases, dysmenorrhea, amenorrhea, menoxenia, and sterility caused by the cold womb, hysteromyoma, cervical cancer, hysteroptosis, mastitis, postpartum persistent lochia, etc. and has a total effective rate of 99.92%. The present invention has the advantages of rapid effect, short course of treatment, cheap price and no toxic action, can be taken through oral administration and outer application, and can be a specialized medicine with dual purpose of inner application and outer application.

Description

The pharmaceutical preparation of treatment, prevention gynecological diseases
The present invention relates to a kind of new Chinese medicine preparation, the pharmaceutical preparation Fubingkang of particularly a kind of treatment of pure Chinese medicine composition pharmaceutical formulation, prevention gynecological diseases, its dosage form can be decoct, oral liquid, tablet, electuary, pill or capsule etc.
Metrorrhagia, leukorrheal diseases, dysmenorrhea, amenorrhea, menoxenia, cold womb are infertile, hysteromyoma, cervical cancer, uterine prolapse, mastitis, lochia are more than etc., and woman, obstetrics' illness are serious harm WomanHealth, life-threatening common clinical.
At present, the clinical practice Western medicine only is single illness symptomatic treatment, cures the symptoms, not the disease, the course of treatment is long, expense high, short term effect still can, late result is then undesirable; Chinese medicine such as gujing pill, SHENGHUATANG ball, BAIDAI WAN, TONGJING WAN etc., though curative effect is better than Western medicine, also mostly is symptomatic treatments, and does not make prophylactic applications, and mostly be oral can not external.
Purpose of the present invention, overcome the deficiencies in the prior art exactly, utilize traditional Chinese medical theory and experience, excavate the natural resources of Chinese medicinal materials of motherland's preciousness, develop a kind of pure Chinese medicine reasonable compatibility prescription, not only can treat but also can prevent, the treating both the principal and secondary aspects of a disease applied range all has significant curative effect to many department of obstetrics and gynecology common diseases, the fast short treating period of produce effects, inexpensive and do not have toxicity, but with a kind of medicine not only oral administration but also external, also can the inside and outside training medication of holding concurrently and using mutually.
Task of the present invention is implemented with following technical scheme:
The pharmaceutical preparation Fubingkang of a kind of treatment of development and design, prevention gynecological disease loyalty, it has contained principal agent and pharmaceutic adjuvant, the solvent etc. of therapeutical effect, it is characterized in that:
1. the principal agent of Fubingkang be a kind of by tonic and blood circulation promoting and blood stasis dispelling, heat clearing away regulate the flow of vital energy, Chinese crude drug such as analgesic hemostatic medicine is main mulit-combination formula,
2. in the combination formula of each Chinese crude drug, during the multi-flavor combination, the part by weight of each component can be: tonic 20~80%, and blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 20~80%,
3. tonic can be selected from following medical material:
Colla Corii Asini, the Radix Astragali, Colla Plastri Testudinis, Radix Angelicae Sinensis, Colla cornus cervi, Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Semen Euryales, Fructus Lycii, Rhizoma Curculiginis, Rhizoma Cibotii, Arillus Longan, the Cortex Eucommiae, Radix Ginseng, Carapax Trionycis, Radix Glycyrrhizae,
4. blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, the analgesic hemostatic medicine can select from following medical material:
Radix Notoginseng, Hirudo, Flos Carthami, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, Fructus Aurantii, Rhizoma Chuanxiong, Radix Polygalae, Oletum Trogopterori, Pollen Typhae, Radix Sanguisorbae, Herba Agrimoniae, Herba Leonuri, Fructus Crataegi, Rhizoma Smilacis Glabrae, Herba Verbenae, Os Sepiae, Radix Gentianae, pollen, red degree, Fructus Akebiae, Squama Manis, Flos Lonicerae, Herba Taraxaci, Fructus Trichosanthis, Ramulus Cinnamomi, Rhizoma Cimicifugae.
The pharmaceutical preparation Fubingkang of above-mentioned treatment, prevention gynecological disease loyalty, its dosage form can be decoct, oral liquid, tablet, electuary, pill or capsule etc.
The pharmaceutical preparation Fubingkang of above-mentioned treatment, prevention gynecological diseases, described all medical materials, after dividing other to press the process of preparing Chinese medicine of Chinese Pharmacopoeia medicinal material processing general rule, pulverize or after extracting, remove slag, concentrating, press each dosage form item such as decoct, oral liquid, tablet, electuary, pill or capsule of regulation under the Chinese Pharmacopoeia rules of preparations item more respectively and stipulate down to make.
The pharmaceutical preparation Fubingkang of above-mentioned treatment, prevention gynecological diseases, its therapeutic dose can be very big or minimum, can be once a day, and two are once or every day 3~6 times, decide on the state of an illness and patient's body constitution.
In the prescription, Colla Corii Asini, Colla Plastri Testudinis, the Colla cornus cervi YIN nourishing of enriching blood, kidney tonifying hemostasis; The Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong qi and blood tonifying, menstruction regulating and pain relieving, blood circulation promoting regulates qi; Radix Panacis Quinquefolii, Rhizoma Atractylodis Macrocephalae invigorating QI to relieve exhaustion, invigorating the spleen and replenishing QI, the hidroschesis of calming the nerves; Rhizoma Dioscoreae, the strong spleen of Semen Euryales the kidney invigorating, relieving leukorrhea by astringents; Fructus Lycii, Rhizoma Curculiginis, Rhizoma Cibotii nourishing liver and kidney, strong positive beneficial marrow; Arillus Longan, Fructus Aurantii, Radix Polygalae invigorating the heart and spleen, stomach function regulating nourishes blood, tranquilizing the mind; Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, antiabortive; The Radix Ginseng strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves; The Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; Radix Notoginseng, Hirudo nourishing blood and hemoslasis, the removing food stagnancy removing blood stasis; The Flos Carthami promoting blood circulation to remove obstruction in the collateral, removing pathogenic heat from blood and toxic substance from the body; Rhizoma Curcumae circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving; Rhizoma Cyperi, Radix Bupleuri depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving; Trogopterus dung charcoal, Pollen Typhae carbon, charred Radix Sanguisorbae are invigorated blood circulation with hemostasis; The Herba Agrimoniae astringing to arrest bleeding; The Herba Leonuri promoting blood flow to regulate menstruation; Fructus Crataegi circulation of qi promoting dissipating blood stasis; The Rhizoma Smilacis Glabrae dehumidifying, detoxifcation, easing joint movement; The Herba Verbenae promoting blood circulation to remove blood stasis; The Os Sepiae astringing to arrest bleeding, leukorrhagia stopping; The Radix Gentianae heat clearing and damp drying, the pathogenic fire purging arresting convulsion; The pollen clearing away heat and promoting production of body fluid, detumescence and apocenosis; The Cortex Moutan clearing away heat and cooling blood, promoting blood circulation to remove blood stasis; The Fructus Akebiae depressed liver-energy dispersing and QI regulating, parasite killing is treated legendary venomous insect, treats all poison; The Squama Manis stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral; The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating; The Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Fructus Trichosanthis heat clearing away eliminating stagnation; The Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins; The Rhizoma Cimicifugae heat-clearing and toxic substances removing, the elevate a turnable ladder yang-energy; Reasonable combination complements each other.
The function of " Fubingkang " is a benefiting qi and nourishing blood, regulating menstruation, hemostasis, saturating stasis of blood removing heat from blood, warm palace leukorrhagia stopping.Cure mainly the two losss of QI and blood, waist abdomen pain, fatigue in both spirit and physical strength, metrorrhagia, leukorrhagia, menoxenia, dysmenorrhea, amenorrhea, lump in the abdomen, cold womb, infertile disease such as grade.
Clinically be used for the treatment of that dysmenorrhea, menoxenia, leucorrhoea grow in quantity, vagina are irregularly bled, over thousands of routine total effective rates 99.92% such as gynecological's disease loyalty such as sterility, hysteromyoma, cervical cancer, uterine prolapse, mastitis, lochia are more than.
Model case:
1. Lee, 51 years old, certain one served the worker of society, went to a doctor the main suit on October 5th, 1991: vagina is irregular bleed month surplus.
The patient removes weight and to cause vaginal hemorrhage more than in month cause, and blood volume reaches over thousands of milliliter, once gives treatments such as blood transfusion, dilatation and curettage, carbazochrome salicylate at civilian hospital, still haemophilia.Change my institute's department of Chinese medicine diagnosis and treatment, examine and see: pale complexion, dizzy cardiopalmus, shortness of breath and fatigue is vexedly slept, xerostomia do not think drink, no appetite less, the vagoue pain of lumbus and abdomen, light red tongue Bai Shaojin, hollow pulse, suddenly give oral " Fubingkang " decoct, every day twice, each 200ml, next day, blood ended, change into once a day, each 200ml serve on drug withdrawal in three days.Follow up a case by regular visits to after half a year, not recurrence again.
2. Shao, 39 years old, the teacher, son was gone to a doctor on March 2nd, 1992, and the main suit: menstruation postpones, and leucorrhoea grow in quantity year is surplus.Examine and see: soreness of waist stomachache, postponed menstruation, profuse leukorrhea, yellow skin or red double mutually in vain, pudendum burning sensation, xerostomia dysphoria with smothery sensation, tinnitus cardiopalmus, the hyperhidrosis of sleeping less, red tongue, yellow and thin fur, thready and rapid pulse gives oral " Fubingkang " tablet, every day three times, each five, take two days later, white fulminant leucorrhagia with yellowish discharge obviously reduces, serve on seven after drug withdrawal.Follow up a case by regular visits to after three months, menstruation is risen as scheduled, and all recover normal.
3. Liu, 28 years old, the workman went to a doctor March 27 nineteen ninety, unpregnancy was examined because of 6 years after marriage, once, few abdomen weighs down and expands when coming about 25 days in menstruation usually, the soreness of waist bitterly, white and thin fur, a little less than the deep-thready pulse, lover's health.Give oral " Fubingkang " oral liquid, every day three times, each 25ml, take five after, menstruation transfers to normally substantially.Nineteen ninety further consultation on April 22, menstrual onset, deep-thready pulse is strong.Advise and took medicine once in its per two days, logotype three times is treated to join the onset of ovulation.Further consultation on July 20 in 1991, menolipsis is two months, and the commentaries on classics gynecologial examination is an early pregnancy.In on February 10th, 1992 the court's department of obstetrics and gynecology natural labor one girl baby.
4. Zhang, 42 years old, the workman went to a doctor on February 8th, 1992, examined and saw: menstruation in advance, and is lasting through row, the time and dripping urine endlessly, or suddenly greatly down, companion's distention and pain in the lower abdomen, leucorrhoea grow in quantity, dimly red tongue or blood stasis point, deep and hesitant pulse.
Diagnosis: hysteromyoma.
Give oral " Fubingkang " decoct, every day three times, each 150ml, take three after, symptom obviously alleviates, took medicine for two weeks, transference cure, menstruation transfers to normally.December was followed up a case by regular visits on the 22nd in 1991, and the patient does not have any discomfort, normally working.
5. Wang, 48 years old, the cadre went to a doctor on April 2nd, 1991, examined and saw: lower abdomen pain, vaginal secretions increases, the turbid Huang of color master, breath malodor, the xerostomia hardship, the cervix uteri local necrosis, and severe infections is arranged.Dimly red tongue, thick fur Huang, slippery and rapid pulse.
Diagnosis: cervical cancer.
Give oral " Fubingkang " decoct, every day twice, each 300ml, local external application once a day, in one week of drug combination, lower abdomen pain obviously alleviates, vaginal secretions reduces.After five weeks of medication, negative several times continuously by multiple punch biopsy, follow up a case by regular visits to after 1 year, not recurrence again.
6. Zhao, 56 years old, the cadre went to a doctor on February 1st, 1992, examined and saw: have thing to hang down to vaginal orifice in the vagina, big as pyriform, conscious lower abdomen drops, fatigue in both spirit and physical strength, shortness of breath and palpitation, frequent micturition, leucorrhoea grow in quantity, light red tongue, white and thin fur, floating pulse and void.
Diagnosis: uterine prolapse.
Give oral " Fubingkang " honeyed pill, every day twice, each two balls are taken a week, and symptom is clearly better, around the medication, and transference cure.Follow up a case by regular visits to not recurrence again after half a year.
7. Chen, 32 years old, the workman, on October 6th, 1991 went to a doctor, and examined and saw: bilateral breast red and swollen heat pain, the shiver with cold cold extremities, hyperpyrexia, lump central authorities are gradually soft, by it fluctuation arranged, yellow and greasy fur, wiry and frequent pulse.
Diagnosis: acute mastitis.
Give oral " Fubingkang " watered pill, every day three times, each nine grams, the watered pill melts the loyal place of external application simultaneously, once a day, drug combination three days, transference cure.Follow up a case by regular visits to after three months, not recurrence again.
8. hole, 27 years old, the teacher, on July 5th, 1991 went to a doctor, and examined and saw: the lochia dripping urine endlessly, the few color purple of amount accompanies clot or residual fetal membrane, distending pain uncomfortable in chest, the lower abdominal pain tenderness, uterine contraction is bad, and the body of the tongue limit is purple dark, deep and forceful pulse.
Diagnosis: lochia is more than.
Give oral " Fubingkang " oral liquid, every day three times, each 30ml, take a week after, transference cure, the bimester after follow up a case by regular visits to, safe and sound.
By above model case, prove that " Fubingkang " has following advantage:
The curative effect height, effect is strong, instant effect, avirulence, be better than existing in, the western drug preparation; Cost is low; Technology does not have the specific condition requirement: medicine source abundance, preparation stabilization, easy to use etc.; Broad market prospect, social benefit and remarkable in economical benefits have reached intended purposes of the present invention preferably.
The present invention is further elaborated below in conjunction with embodiment:
[embodiment one] prepares " Fubingkang " decoct, in following ratio compatibility:
Tonic 80%, blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 20%;
Concrete medication is:
Colla Corii Asini, the Radix Astragali, Colla Plastri Testudinis, Radix Angelicae Sinensis, each 10g of Colla cornus cervi, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, the Cortex Eucommiae, Radix Ginseng, Carapax Trionycis, each 5g of Radix Glycyrrhizae, Radix Notoginseng, pollen, Herba Leonuri, each 5g of Rhizoma Curcumae.
Technical process:
Above-mentioned all flavor medical materials are gone into Decocting pot, add entry and cross powder, decoct three times, and to boiling, 1h first, 2,3 30min, filter cleaner merges three times decoction liquor, and is concentrated slightly, fine straining, embedding is in the 250ml bottle, and sterilization is up to the standards by medicinal requirements, and the drug standard packing gets final product.
[embodiment two] prepare " Fubingkang " oral liquid, in following ratio compatibility:
Tonic 40%, blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 60%
Concrete medication is:
Colla Corii Asini, Colla Plastri Testudinis, Radix Panacis Quinquefolii, Rhizoma Dioscoreae, Semen Euryales, Fructus Lycii, Rhizoma Curculiginis, each 5g of Rhizoma Cibotii, Hirudo, Rhizoma Cyperi, Radix Bupleuri, Fructus Aurantii, Fructus Trichosanthis, Pollen Typhae carbon, charred Radix Sanguisorbae, Herba Agrimoniae, Herba Leonuri, Herba Verbenae, Os Sepiae, Radix Gentianae, pollen, red degree, Fructus Akebiae, each 5g of Squama Manis.
Technical process:
Boil with example one decocting, decoction liquor is concentrated into half amount, adds the sugar of 2% amount and 5 ‰ sodium benzoate, stirs evenly, add distilled water to ormal weight, fine straining, is sterilized in the 10ml ampoule by oral liquid requirement embedding, be up to the standards by the conventional requirement of oral liquid, the drug standard packing gets final product.
[embodiment three] prepare " Fubingkang " electuary, in following ratio compatibility:
Tonic 50%, blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 50%
Colla Corii Asini, Colla Plastri Testudinis, each 10g of Colla cornus cervi, Arillus Longan, the Cortex Eucommiae, Radix Ginseng, each 5g of Carapax Trionycis, Radix Notoginseng, Rhizoma Chuanxiong, Radix Polygalae, Herba Agrimoniae, Herba Leonuri, Fructus Crataegi, Rhizoma Smilacis Glabrae, Os Sepiae, Herba Taraxaci, each 5g of Fructus Trichosanthis.
Technical process:
With decocting three times in example one water.The filtrate evaporation and concentration is to thick paste, and 60 ℃ of oven dry are pulverized, and add 5% sugar, mixing, and the system granule, granulate is sub-packed in the pouch by the electuary requirement, is up to the standards by the pharmacopeia requirement, and the drug standard packing gets final product.
[embodiment four] prepare " Fubingkang " tablet, in following ratio compatibility:
Tonic 60%, blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 40%
Colla Corii Asini, the Radix Astragali, Rhizoma Dioscoreae, each 10g of Fructus Lycii, Rhizoma Cibotii, Arillus Longan, Radix Ginseng, each 5g of Carapax Trionycis, Radix Notoginseng, Flos Carthami, Radix Bupleuri, Herba Agrimoniae, Herba Leonuri, Fructus Crataegi, Rhizoma Smilacis Glabrae, each 5g of Fructus Akebiae.
Technical process:
With decocting three times in example one water.The filtrate evaporation and concentration is to thick paste, and oven dry is pulverized, and adds the adjuvant of convention amount, mixing, and the system granule, granulate, tabletting, sugar coating is sub-packed in the bottle by the tablet requirement.Be up to the standards by the requirement of pharmacopeia tablet, the drug standard packing gets final product.
[embodiment five] prepare " Fubingkang " capsule, in following ratio compatibility:
Tonic 20%, blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 80%
Colla Corii Asini, the Radix Astragali, Colla Plastri Testudinis, each 5g of Radix Angelicae Sinensis, Radix Notoginseng, Hirudo, Flos Carthami, Oletum Trogopterori, Os Sepiae, Fructus Akebiae, Ramulus Cinnamomi, Rhizoma Cimicifugae 10g.
Technical process:
With decocting three times in example one water.The filtrate evaporation and concentration is to thick paste, and oven dry is pulverized, and adds the adjuvant of convention amount, and mixing is made granule, and is encapsulated, asks by capsule to be sub-packed in the bottle.Be up to the standards by the pharmacopeia requirement, the drug standard packing gets final product.
[embodiment six] prepare " Fubingkang " pill, in following ratio compatibility:
Or tonic 70%, blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 30%
Colla Corii Asini, Colla Plastri Testudinis, each 10g of Colla cornus cervi, Fructus Lycii, the Radix Astragali, Rhizoma Cibotii, Arillus Longan, the Cortex Eucommiae, Radix Ginseng, Carapax Trionycis, each 5g of Radix Glycyrrhizae, Radix Notoginseng, Flos Carthami, Rhizoma Cyperi, Pollen Typhae, Os Sepiae, each 5g of Fructus Akebiae.
Technical process:
Except that Radix Notoginseng, all the other medical materials of respectively distinguishing the flavor of boil with example one decocting, merging filtrate, and the medicinal liquid evaporation and concentration adds the Radix Notoginseng fine powder to thick paste, mixes thoroughly, oven dry below 60 ℃, pill, sugar coating is sub-packed in the bottle by the pill requirement.Be up to the standards by requirement under this item of pharmacopeia, the drug standard packing gets final product.
[embodiment seven] prepare " Fubingkang " pill, in following ratio compatibility:
Tonic 45%, blood circulation promoting and blood stasis dispelling, heat clearing away are regulated the flow of vital energy, analgesic hemostatic medicine 55%
Colla Corii Asini, Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Fructus Lycii, Rhizoma Curculiginis, Rhizoma Cibotii, the Cortex Eucommiae, each 5g of Carapax Trionycis, Hirudo, Flos Carthami, Rhizoma Curcumae, Pollen Typhae, Herba Agrimoniae, Herba Leonuri, Rhizoma Smilacis Glabrae, Os Sepiae, pollen, red degree, each 5g of Fructus Akebiae.
Technical process:
Except that Hirudo, all the other medical materials of respectively distinguishing the flavor of boil with example one decocting, merging filtrate, and the medicinal liquid evaporation and concentration adds the Hirudo fine powder to thick paste, mixes thoroughly, oven dry below 60 ℃, 60 ℃ ± add refined honey, be twisted into big honeyed pills, be sub-packed in the bottle by the pill requirement.Be up to the standards by requirement under this item of pharmacopeia, the drug standard packing gets final product.

Claims (1)

1. the pharmaceutical preparation of a treatment, prevention gynecological diseases, it is characterized in that it being the decoct of making by the raw material of following consumption: Colla Corii Asini, the Radix Astragali, Colla Plastri Testudinis, Radix Angelicae Sinensis, each 10g of Colla cornus cervi, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, the Cortex Eucommiae, Radix Ginseng, Carapax Trionycis, Radix Glycyrrhizae, Radix Notoginseng, pollen, Herba Leonuri, each 5g of Rhizoma Curcumae.
CN93111249A 1993-05-24 1993-05-24 Medicinal preparation for treatment and prevention of gynopathy Expired - Fee Related CN1061854C (en)

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CN1061854C true CN1061854C (en) 2001-02-14

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