CN104758607A - Traditional Chinese medicine composition for treating premature ovarian failure - Google Patents
Traditional Chinese medicine composition for treating premature ovarian failure Download PDFInfo
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- CN104758607A CN104758607A CN201510183185.9A CN201510183185A CN104758607A CN 104758607 A CN104758607 A CN 104758607A CN 201510183185 A CN201510183185 A CN 201510183185A CN 104758607 A CN104758607 A CN 104758607A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating a premature ovarian failure. The problem of medication of premature ovarian failure can be effectively solved. According to the technical scheme, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-30 parts of mulberry, 5-20 parts of glossy privet fruit, 5-25 parts of eclipta, 5-15 parts of hippocampus, 1-5 parts of corn cervi pantotrichum, 5-15 parts of eucommia ulmoides, 5-15 parts of cistanche salsa, 5-15 parts of fructus psoraleae, 10-30 parts of polygonatum kingianum, 10-40 parts of manyprickle acanthopanax roots, 10-30 parts of gynostemma pentaphylla, 5-20 parts of angelica sinensis, 5-20 parts of salviae miltiorrhizae and 5-15 parts of flos carthami. The traditional Chinese medicine composition is abundant in raw materials, low in price, scientific in components, and reasonable in compatibility; a plurality of medicines are supported by one another and work together to reach the efficacy of invigorating spleen, supplementing qi, nourishing blood, activating blood circulation, nourishing the liver and kidneys, cultivating uterus and nourishing vigor; and the traditional Chinese medicine composition is effectively used for treating the premature ovarian failure, is good in curative effect, and safe to medicate, and is an innovation in medicines for treating the premature ovarian failure.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine composition for the treatment of premature ovarian failure.
Background technology
Premature ovarian failure (premature overy failure POF) refers to that women occurred amenorrhea after Development in Puberty before 40 years old, and blood estrogen level is low, the disease of promoting sexual gland hormone excessive concentration.Premature ovarian failure belongs to women from endocrinology and enters climacteric in advance, and the main people's of impact is clinical symptoms and infertile generation.Modern medicine is mainly applied as master with Hormone Replacement Therapy, induced ovulation, immunosuppressant to the treatment of premature ovarian failure, and curative effect is better, but there is the problems such as rear relapse rate is high of stopping using.The women of Long-term Hormone supplement therapy suffers stroke, the probability of heart disease, leg thromboembolism, pulmonary embolisms increases, particularly add suffer from breast cancer, the danger of carcinoma of endometrium.Therefore, the improvement and bring new ideas for the treatment of on premature ovarian failure medicine is the problem needing solution at present badly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the object of the present invention is just to provide a kind of Chinese medicine composition for the treatment of premature ovarian failure, effectively can solve the medication problem of premature ovarian failure.
The technical scheme that the present invention solves is made up of the material medicine of following weight parts: Fructus Mori 10-30 part, Fructus Ligustri Lucidi 5-20 part, Herba Ecliptae 5-25 part, Hippocampus 5-15 part, Cornu Cervi Pantotrichum 1-5 part, Cortex Eucommiae 5-15 part, Herba Cistanches 5-15 part, Fructus Psoraleae 5-15 part, Rhizoma Polygonati 10-30 part, Radix Et Caulis Acanthopanacis Senticosi 10-40 part, Herb Gynostemmae Pentaphylli 10-30 part, Radix Angelicae Sinensis 5-20 part, Radix Salviae Miltiorrhizae 5-20 part Flos Carthami 5-15 part.
Abundant raw material of the present invention, cheap, component science, reasonable compatibility, mutual support, all medicines are played invigorating the spleen and benefiting QI, nourshing blood and promoting blood circulation, nourishing the liver and kidney altogether, are educated effect that unit is supported in palace, are effective to treat premature ovarian failure, good effect, drug safety is that on treatment premature ovarian failure medicine innovates greatly.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following weight parts: 11 parts, Fructus Mori, Fructus Ligustri Lucidi 19 parts, Herba Ecliptae 6 parts, Hippocampus 14 parts, 2 parts, Cornu Cervi Pantotrichum, the Cortex Eucommiae 14 parts, Herba Cistanches 6 parts, Fructus Psoraleae 14 parts, Rhizoma Polygonati 11 parts, Radix Et Caulis Acanthopanacis Senticosi 39 parts, Herb Gynostemmae Pentaphylli 11 parts, Radix Angelicae Sinensis 19 parts, Radix Salviae Miltiorrhizae 6 parts of Flos Carthami 14 parts.
Embodiment 2
The present invention in the specific implementation, also can be made up of the material medicine of following weight parts: 20 parts, Fructus Mori, Fructus Ligustri Lucidi 13 parts, Herba Ecliptae 15 parts, Hippocampus 12 parts, 3 parts, Cornu Cervi Pantotrichum, the Cortex Eucommiae 10 parts, Herba Cistanches 10 parts, Fructus Psoraleae 10 parts, Rhizoma Polygonati 20 parts, Radix Et Caulis Acanthopanacis Senticosi 25 parts, Herb Gynostemmae Pentaphylli 20 parts, Radix Angelicae Sinensis 13 parts, Radix Salviae Miltiorrhizae 12 parts of Flos Carthami 10 parts.
Embodiment 3
The present invention in the specific implementation, also can be made up of the material medicine of following weight parts: 29 parts, Fructus Mori, Fructus Ligustri Lucidi 6 parts, Herba Ecliptae 24 parts, Hippocampus 6 parts, 4 parts, Cornu Cervi Pantotrichum, the Cortex Eucommiae 6 parts, Herba Cistanches 14 parts, Fructus Psoraleae 6 parts, Rhizoma Polygonati 29 parts, Radix Et Caulis Acanthopanacis Senticosi 11 parts, Herb Gynostemmae Pentaphylli 29 parts, Radix Angelicae Sinensis 6 parts, Radix Salviae Miltiorrhizae 19 parts of Flos Carthami 6 parts.
Chinese medicine composition of the present invention can according to the needs of clinical practice, preparation method makes decoction routinely, powder (powder), tablet, granule, pill, capsules etc. are suitable for the various dosage forms applied, provide the decoction that conventional method is made below, specifically: first by Fructus Mori, Fructus Ligustri Lucidi, Herba Ecliptae, Hippocampus, Cornu Cervi Pantotrichum, the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae Flos Carthami mixes, put into medicinal cupping, add water to submerge, soak 30-60min, intense fire decocts to boiling, use slow fire boiling 20-30min instead, filter, obtain filtrate, filtering residue adds water to submerge again, intense fire decocts to boiling, use slow fire boiling 20-30min instead, filter, obtain filtrate, merge twice filtrate, mixing.
In instant component:
Fructus Mori: sweet, sour, cold.GUIXIN, liver, kidney channel.To enrich blood YIN nourishing, promote the production of body fluid and moisturize.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.
Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Herba Ecliptae: sweet, sour, cold.Return kidney, Liver Channel.Nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Hippocampus: sweet, temperature.Return liver, kidney channel.Warming the kidney to invigorate YANG, mass dissipating and swelling eliminating.For sexual impotence, the enuresis, suffers from a deficiency of the kidney and breathes heavily, lump in the abdomen, injury from falling down; External treatment carbuncle furuncle.
Cornu Cervi Pantotrichum: sweet, salty, temperature.Return kidney, Liver Channel.Invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, adjusts punching to appoint, holder sore.For sexual impotence spermatorrhea, cold womb is infertile, weakness and emaciation, Mental fatigue, fear of cold, and vertigo and tinnitus is deaf, and spinal column cold type of pain, muscles and bones flaccidity is soft, bleeding not during menses, and carbuncle of yin nature is not held back.
The Cortex Eucommiae: sweet, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Herba Cistanches: sweet, salty, temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.
Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.Warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Rhizoma Polygonati: sweet is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Radix Et Caulis Acanthopanacis Senticosi: pungent, micro-hardship, temperature.Return spleen, kidney, heart channel.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Herb Gynostemmae Pentaphylli: bitter in the mouth; Micro-sweet; Cool in nature.Return lung; Spleen; Kidney channel.Heat clearing away; Tonify deficiency; Removing toxic substances.Main body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Flos Carthami: pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
The Chinese medicine composition that the present invention treats premature ovarian failure is based on fundamental Chinese medicine theory, develops to have invigorating the spleen and benefiting QI, nourshing blood and promoting blood circulation, nourishing the liver and kidney, educate the Chinese medicine composition that effect of unit is supported in palace.Fructus Mori, Fructus Ligustri Lucidi, Herba Ecliptae nourishing the liver and kidney in prescription, Hippocampus, Cornu Cervi Pantotrichum, the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae are educated palace and are supported unit, and Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli invigorating the spleen and benefiting QI, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Flos Carthami nourshing blood and promoting blood circulation stimulate the menstrual flow.
Full side utilizes the comprehensive function treatment premature ovarian failure of every Chinese medicine, harmless to human non-toxic, good effect, drug safety, and obtains sufficient proof through clinical experiment, and pertinent clinical experimental data is as follows:
Chinese medicine composition of the present invention for decoction,
1, physical data
In 80 routine patients, be divided into treatment group and matched group at random.Treatment group 40 example, 25 ~ 40 years old age, average (35.14 ± 9.83) year; Amenorrhea or hypomenorrhea time 0.5-4, average (1.78 ± 0.53) year; Matched group 40 example, 24 ~ 41 years old age, average (34.97 ± 10.12) year; Amenorrhea or hypomenorrhea time 0.5-4.5, average (1.82 ± 0.68) year.2 groups of data are through statistical procedures, and in age, the state of an illness, difference there are no significant meaning (P>0.05), has comparability.
2, diagnostic criteria
According to " clinical manifestation of premature ovarian failure and diagnostic criteria " [Xu Ling, Song Yijun. the clinical manifestation of premature ovarian failure and diagnostic criteria [J]. practical journal of obstetrics and gynecology, 2003,19 (4): 195-196] formulate.1. the age is less than 40 years old; 2. menstrual cycle is set up, but occurs suddenly that without inducement amenorrhea reaches more than 4 months; Or first have hypomenorrhea then amenorrhea to reach more than 4 months; 3. blood estrogen and Gonadotropin Level: to have 2 times or more twice more than 1 month interval time of serum FSH >40IU/L(), E
2<73.2pmol/L, Prolactin (PRL) is normal.
3, therapeutic scheme
Treatment group: use Chinese medicine composition of the present invention to make decoction, sooner or later respectively once, decoction being taken warmly, each 200-300ml.Serve on to menstrual onset, menstrual period withdraw.Treating 3 menstrual cycle was 1 course for the treatment of, took 3 courses for the treatment of continuously.Western medicine artificial cycle is treated: reinstate diethylstilbestrol 0.25mg from menstrual cycle 5d or the medical same day, every day 1 time, 20d, in the 16d that takes medicine, add and use medroxyprogestetone acetate 4mg, every 12h 1 time, 7d, or Progesterone 10mg intramuscular injection, every day 1 time, 5d, is used in conjunction 3 menstrual cycle.
Matched group: treat with treatment group simple western medicine artificial cycle.
4, efficacy assessment standard
Recovery from illness: menstruation recovery normal cycle after treatment, other symptoms disappear substantially, and after drug withdrawal, menstruation maintains more than 3 cycles.
Effective: menstruation is close to normal cycle (within 40 days), and in drug withdrawal 3 months, menstruation is risen 1 time automatically, and other symptoms are improved.
Effective: to treat in 3 months menstrual onset 1 time, other symptoms make moderate progress.
Invalid: treatment 3 months continuously, menstruation has no rises.
5, statistical procedures
Adopt SPSS13.0 statistical software, enumeration data adopts x2 inspection, and ranked data adopt Ridit inspection.
5.1 by above-mentioned therapeutic scheme, the Chinese medicine composition decoction that oral the present invention provides, as can be seen from Table 1, treatment group recovery from illness 16 example, effective 12 examples, effective 10 examples, invalid 2 examples, total effective rate is 95%; Matched group recovery from illness 10 example, effective 10 examples, effective 12 examples, invalid 8 examples, total effective rate is 80%.Treatment group compares with matched group, and recovery from illness, invalid and total effective rate have remarkable significant difference.
table 1 liang group Clinical efficacy comparison
Compare with matched group, * P < 0.05, * * P < 0.01
Before and after 5.2 liang of group treatments, Serum Sex Hormones parameter compares
As can be seen from Table 2, after treatment group and treatment of control group, FSH significantly declines, and E2 significantly rises, with organize treat before compare, have remarkable statistical significance (P < 0.01); After treatment group treatment, obvious reduction after FSH level and treatment of control group, E2 level obviously raises, and has obvious significant difference (P < 0.05).
Before and after table 2 liang group treatment, Serum Sex Hormones parameter compares
Note: compare * P < 0.05 before and after each group treatment; * P < 0.01; △ P < 0.05 is compared with matched group
Chinese medicine composition of the present invention is through making other dosage forms; all achieve identical or close result in an experiment; will not enumerate, prevent tired stating, and; what the application's request was protected is Chinese medicine composition (component invention); and do not lie in dosage form or preparation method, and therefore, arbitrary dosage form that all employing the application Chinese medicine composition prescriptions are made; and be used for the treatment of the medicine of premature ovarian failure, all belong to the scope of the application's protection.
6, conclusion
Component science of the present invention, abundant raw material, cheap, reasonable compatibility, mutual support, all medicines are played invigorating the spleen and benefiting QI, nourshing blood and promoting blood circulation, nourishing the liver and kidney altogether, are educated effect that unit is supported in palace, are effective to treat premature ovarian failure, good effect, drug safety, effective percentage, up to 95%, is that one on Chinese medicine is innovated greatly, has actual clinical meaning.
Claims (5)
1. treat the Chinese medicine composition of premature ovarian failure for one kind, it is characterized in that, be made up of the material medicine of following weight parts: Fructus Mori 10-30 part, Fructus Ligustri Lucidi 5-20 part, Herba Ecliptae 5-25 part, Hippocampus 5-15 part, Cornu Cervi Pantotrichum 1-5 part, Cortex Eucommiae 5-15 part, Herba Cistanches 5-15 part, Fructus Psoraleae 5-15 part, Rhizoma Polygonati 10-30 part, Radix Et Caulis Acanthopanacis Senticosi 10-40 part, Herb Gynostemmae Pentaphylli 10-30 part, Radix Angelicae Sinensis 5-20 part, Radix Salviae Miltiorrhizae 5-20 part Flos Carthami 5-15 part.
2. the Chinese medicine composition for the treatment of premature ovarian failure according to claim 1, it is characterized in that, be made up of the material medicine of following weight parts: 11 parts, Fructus Mori, Fructus Ligustri Lucidi 19 parts, Herba Ecliptae 6 parts, Hippocampus 14 parts, 2 parts, Cornu Cervi Pantotrichum, the Cortex Eucommiae 14 parts, Herba Cistanches 6 parts, Fructus Psoraleae 14 parts, Rhizoma Polygonati 11 parts, Radix Et Caulis Acanthopanacis Senticosi 39 parts, Herb Gynostemmae Pentaphylli 11 parts, Radix Angelicae Sinensis 19 parts, Radix Salviae Miltiorrhizae 6 parts of Flos Carthami 14 parts.
3. the Chinese medicine composition for the treatment of premature ovarian failure according to claim 1, it is characterized in that, be made up of the material medicine of following weight parts: 20 parts, Fructus Mori, Fructus Ligustri Lucidi 13 parts, Herba Ecliptae 15 parts, Hippocampus 12 parts, 3 parts, Cornu Cervi Pantotrichum, the Cortex Eucommiae 10 parts, Herba Cistanches 10 parts, Fructus Psoraleae 10 parts, Rhizoma Polygonati 20 parts, Radix Et Caulis Acanthopanacis Senticosi 25 parts, Herb Gynostemmae Pentaphylli 20 parts, Radix Angelicae Sinensis 13 parts, Radix Salviae Miltiorrhizae 12 parts of Flos Carthami 10 parts.
4. the Chinese medicine composition for the treatment of premature ovarian failure according to claim 1, it is characterized in that, be made up of the material medicine of following weight parts: 29 parts, Fructus Mori, Fructus Ligustri Lucidi 6 parts, Herba Ecliptae 24 parts, Hippocampus 6 parts, 4 parts, Cornu Cervi Pantotrichum, the Cortex Eucommiae 6 parts, Herba Cistanches 14 parts, Fructus Psoraleae 6 parts, Rhizoma Polygonati 29 parts, Radix Et Caulis Acanthopanacis Senticosi 11 parts, Herb Gynostemmae Pentaphylli 29 parts, Radix Angelicae Sinensis 6 parts, Radix Salviae Miltiorrhizae 19 parts of Flos Carthami 6 parts.
5. the Chinese medicine composition of claim 1 or the treatment premature ovarian failure described in any one of 2-4, preparation method can make any one in decoction, powder, tablet, granule, pill, capsule or oral liquid routinely.
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Cited By (3)
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| CN105943651A (en) * | 2016-06-27 | 2016-09-21 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating premature ovarian failure, and application thereof |
| CN114010705A (en) * | 2021-11-27 | 2022-02-08 | 江苏万可瑞科技实业有限公司 | Preparation for treating premature ovarian failure of women by double-combination therapy and preparation method thereof |
| CN116603030A (en) * | 2023-05-27 | 2023-08-18 | 陕西年青保制药有限公司 | Traditional Chinese medicine composition and preparation for premature ovarian failure and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943651A (en) * | 2016-06-27 | 2016-09-21 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating premature ovarian failure, and application thereof |
| CN105943651B (en) * | 2016-06-27 | 2019-10-01 | 上海中医药大学附属岳阳中西医结合医院 | A kind of Chinese medicine composition that treating premature ovarian failure and its application |
| CN114010705A (en) * | 2021-11-27 | 2022-02-08 | 江苏万可瑞科技实业有限公司 | Preparation for treating premature ovarian failure of women by double-combination therapy and preparation method thereof |
| CN116603030A (en) * | 2023-05-27 | 2023-08-18 | 陕西年青保制药有限公司 | Traditional Chinese medicine composition and preparation for premature ovarian failure and preparation process thereof |
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