CN104758844A - Traditional Chinese medicine for treating premature ovarian failure - Google Patents
Traditional Chinese medicine for treating premature ovarian failure Download PDFInfo
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- CN104758844A CN104758844A CN201510183098.3A CN201510183098A CN104758844A CN 104758844 A CN104758844 A CN 104758844A CN 201510183098 A CN201510183098 A CN 201510183098A CN 104758844 A CN104758844 A CN 104758844A
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Abstract
The invention relates to a traditional Chinese medicine for treating premature ovarian failure. The traditional Chinese medicine can be used for effectively solving the problem of medication of premature ovarian failure. The technical scheme for solving the problem is as follows: the traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 5-20 parts of glossy privet fruit, 5-20 parts of barbary wolfberry fruit, 3-12 parts of donkey-hide glue, 5-25 parts of palmleaf raspberry fruit, 1-5 parts of dried human placenta, 3-10 parts of tokay, 5-15 parts of Chinese caterpillar fungus, 5-15 parts of turmeric root-tuber, 10-30 parts of akebia fruit, 5-20 parts of Chinese angelica, 10-20 parts of salvia miltiorrhiza and 3-10 parts of motherwort fruit. The traditional Chinese medicine provided by the invention is rich in raw material, low in price, scientific in composition and reasonable in compatibility, and the medicinal materials support one another and act together to achieve the effects of nourishing yin and blood, enriching kidney essence, soothing the liver and relieving depression, as well as nourishing blood and promoting blood circulation, so that the traditional Chinese medicine is good in curative effect and safe in medication when effectively used for treating the premature ovarian failure, and is a big innovation of medicaments for treating the premature ovarian failure.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine for the treatment of premature ovarian failure.
Background technology
premature ovarian failure (PrematuerOvarinaFaliuer, POF) is also known as Turner syndrome.Refer to the normal or delayed puberty of Menarcheal Age, the normotrophic women of secondary sex characteristics amenorrhea before 40 years old, companion's priatin level raises and decrease in estrogen.Clinical manifestation is amenorrhea, infertile, hectic fever hyperhidrosis, leucorrhea minimizing, vaginal dryness, degradation makes patient's geromorphism under libido, and to it, physically and mentally healthy and love life brings considerable distress.Modern medicine is mainly applied as master with Hormone Replacement Therapy, induced ovulation, immunosuppressant to the treatment of premature ovarian failure, and curative effect is better, but there is the problems such as rear relapse rate is high of stopping using.The women of Long-term Hormone supplement therapy suffers stroke, the probability of heart disease, leg thromboembolism, pulmonary embolisms increases, particularly add suffer from breast cancer, the danger of carcinoma of endometrium.Therefore, the improvement and bring new ideas for the treatment of on premature ovarian failure medicine is the problem needing solution at present badly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the object of the present invention is just to provide a kind of Chinese medicine for the treatment of premature ovarian failure, effectively can solve the medication problem of premature ovarian failure.
The technical scheme that the present invention solves is made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 5-20 part, Fructus Lycii 5-20 part, Colla Corii Asini 3-12 part, Fructus Rubi 5-25 part, Placenta Hominis 1-5 part, Gecko 3-10 part, Cordyceps 5-15 part, Radix Curcumae 5-15 part, Fructus Akebiae 10-30 part, Radix Angelicae Sinensis 5-20 part, Radix Salviae Miltiorrhizae 10-20 part and Fructus Leonuri 3-10 part.
Abundant raw material of the present invention, cheap, component science, reasonable compatibility, mutual support, effect of nourishing YIN and benefiting blood, enriching kidney essence, dispersing the stagnated live-QI to relieve the stagnation of QI, nourshing blood and promoting blood circulation played altogether by all medicines, is effective to treat premature ovarian failure, good effect, drug safety is that on treatment premature ovarian failure medicine innovates greatly.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 6 parts, Fructus Lycii 19 parts, 4 parts, Colla Corii Asini, Fructus Rubi 24 parts, Placenta Hominis 2 parts, Gecko 9 parts, Cordyceps 6 parts, Radix Curcumae 14 parts, Fructus Akebiae 11 parts, Radix Angelicae Sinensis 19 parts, Radix Salviae Miltiorrhizae 11 parts and Fructus Leonuri 9 parts.
Embodiment 2
The present invention in the specific implementation, also can be made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 12 parts, Fructus Lycii 13 parts, 7 parts, Colla Corii Asini, Fructus Rubi 15 parts, Placenta Hominis 3 parts, Gecko 6 parts, Cordyceps 10 parts, Radix Curcumae 10 parts, Fructus Akebiae 20 parts, Radix Angelicae Sinensis 12 parts, Radix Salviae Miltiorrhizae 15 parts and Fructus Leonuri 7 parts.
Embodiment 3
The present invention in the specific implementation, also can be made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 19 parts, Fructus Lycii 6 parts, 11 parts, Colla Corii Asini, Fructus Rubi 6 parts, Placenta Hominis 4 parts, Gecko 4 parts, Cordyceps 14 parts, Radix Curcumae 6 parts, Fructus Akebiae 29 parts, Radix Angelicae Sinensis 6 parts, Radix Salviae Miltiorrhizae 19 parts and Fructus Leonuri 4 parts.
Chinese medicine composition of the present invention can according to the needs of clinical practice, preparation method makes decoction routinely, powder (powder), tablet, granule, pill, capsules etc. are suitable for the various dosage forms applied, provide the decoction that conventional method is made below, specifically: first by Fructus Ligustri Lucidi, Fructus Lycii, Colla Corii Asini, Fructus Rubi, Placenta Hominis, Gecko, Cordyceps, Radix Curcumae, Fructus Akebiae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae and Fructus Leonuri mix, put into medicinal cupping, add water to submerge, soak 30-60min, intense fire decocts to boiling, use slow fire boiling 20-30min instead, filter, obtain filtrate, filtering residue adds water to submerge again, intense fire decocts to boiling, use slow fire boiling 20-30min instead, filter, obtain filtrate, merge twice filtrate, mixing.
In instant component:
Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Fructus Lycii: sweet is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Colla Corii Asini: sweet is flat.Return lung, liver, kidney channel.To enrich blood YIN nourishing, moisturize, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Fructus Rubi: sweet, sour, temperature.Return kidney, urinary bladder channel.Kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.
Placenta Hominis: sweet, salty, temperature.GUIXIN, lung, kidney channel.The kidney warming mends essence, benefiting QI and nourishing blood.For asthenia weakness and emaciation, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia.
Gecko: salty, flat.Return lung, kidney channel.Invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence.For dyspnea due to deficiency tachypnea, chronic cough hemoptysis, impotence and seminal emission.
Cordyceps: sweet is flat.Return lung, kidney channel.Invigorating the lung and the kidney, hemostasis and phlegm.For chronic cough dyspnea due to deficiency, chronic cough is spat blood, impotence and seminal emission, soreness of waist and knee joint.
Radix Curcumae: pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Fructus Akebiae: micro-hardship, property is put down.Return liver, stomach, urinary bladder channel.Liver; Stomach warp.Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Salviae Miltiorrhizae: property is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Fructus Leonuri: pungent, bitter, is slightly cold.GUIXIN bag, Liver Channel.Promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.
The Chinese medicine that the present invention treats premature ovarian failure is based on fundamental Chinese medicine theory, develops the Chinese medicine of effect with nourishing YIN and benefiting blood, enriching kidney essence, dispersing the stagnated live-QI to relieve the stagnation of QI, nourshing blood and promoting blood circulation.Fructus Ligustri Lucidi, Fructus Lycii, Colla Corii Asini nourishing YIN and benefiting blood in prescription, Fructus Rubi, Placenta Hominis, Gecko, Cordyceps enriching kidney essence, Radix Curcumae, Fructus Akebiae dispersing the stagnated live-QI to relieve the stagnation of QI, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Leonuri nourshing blood and promoting blood circulation.
Full side utilizes the comprehensive function treatment premature ovarian failure of every Chinese medicine, harmless to human non-toxic, good effect, drug safety, and obtains sufficient proof through clinical experiment, and pertinent clinical experimental data is as follows:
Chinese medicine composition of the present invention for decoction,
1, physical data
In 90 routine patients, be divided into treatment group and matched group at random.Treatment group 45 example, 23 ~ 41 years old age, average (36.21 ± 10.15) year; Amenorrhea or hypomenorrhea time 0.5-5, average (1.71 ± 0.48) year; Matched group 45 example, 24 ~ 40 years old age, average (33.89 ± 9.43) year; Amenorrhea or hypomenorrhea time 0.5-5, average (1.79 ± 0.52) year.2 groups of data are through statistical procedures, and in age, the state of an illness, difference there are no significant meaning (P>0.05), has comparability.
2, diagnostic criteria
According to " clinical manifestation of premature ovarian failure and diagnostic criteria " [Xu Ling, Song Yijun. the clinical manifestation of premature ovarian failure and diagnostic criteria [J]. practical journal of obstetrics and gynecology, 2003,19 (4): 195-196] formulate.1. the age is less than 40 years old; 2. menstrual cycle is set up, but occurs suddenly that without inducement amenorrhea reaches more than 4 months; Or first have hypomenorrhea then amenorrhea to reach more than 4 months; 3. blood estrogen and Gonadotropin Level: to have 2 times or more twice more than 1 month interval time of serum FSH >40IU/L(), E
2<73.2pmol/L, Prolactin (PRL) is normal.
3, therapeutic scheme
Treatment group: use Chinese medicine of the present invention to make decoction, sooner or later respectively once, decoction being taken warmly, each 200-300ml.Serve on to menstrual onset, menstrual period withdraw.Treating 3 menstrual cycle was 1 course for the treatment of, took 3 courses for the treatment of continuously.Western medicine artificial cycle is treated: reinstate diethylstilbestrol 0.25mg from menstrual cycle 5d or the medical same day, every day 1 time, 20d, in the 16d that takes medicine, add and use medroxyprogestetone acetate 4mg, every 12h 1 time, 7d, or Progesterone 10mg intramuscular injection, every day 1 time, 5d, is used in conjunction 3 menstrual cycle.
Matched group: treat with treatment group simple western medicine artificial cycle.
4, efficacy assessment standard
Recovery from illness: menstruation recovery normal cycle after treatment, other symptoms disappear substantially, and after drug withdrawal, menstruation maintains more than 3 cycles.
Effective: menstruation is close to normal cycle (within 40 days), and in drug withdrawal 3 months, menstruation is risen 1 time automatically, and other symptoms are improved.
Effective: to treat in 3 months menstrual onset 1 time, other symptoms make moderate progress.
Invalid: treatment 3 months continuously, menstruation has no rises.
5, statistical procedures
Adopt SPSS13.0 statistical software, enumeration data adopts x2 inspection, and ranked data adopt Ridit inspection.
5.1 by above-mentioned therapeutic scheme, the Chinese medicine decoction that oral the present invention provides, as can be seen from Table 1, treatment group recovery from illness 17 example, effective 13 examples, effective 12 examples, invalid 3 examples, total effective rate is 93.3%; Matched group recovery from illness 12 example, effective 11 examples, effective 13 examples, no effect 9, total effective rate is 80%.Treatment group compares with matched group, and recovery from illness, invalid and total effective rate have remarkable significant difference.
Table 1 liang group Clinical efficacy comparison
Compare with matched group, * P < 0.05, * * P < 0.01
Before and after 5.2 liang of group treatments, Serum Sex Hormones parameter compares
As can be seen from Table 2, after treatment group and treatment of control group, FSH significantly declines, and E2 significantly rises, with organize treat before compare, have remarkable statistical significance (
p< 0.01); After treatment group treatment, obvious reduction after FSH level and treatment of control group, E2 level obviously raises, have obvious significant difference (
p< 0.05).
Before and after table 2 liang group treatment, Serum Sex Hormones parameter compares
Note: compare before and after each group treatment
* P<0.05
; * P< 0.01; △ is compared with matched group
p< 0.05
Chinese prescription of the present invention is through making other dosage forms; all achieve identical or close result in an experiment; will not enumerate, prevent tired stating, and; what the application's request was protected is Chinese prescription (component invention); and do not lie in dosage form or preparation method, and therefore, arbitrary dosage form that all employing the application Chinese prescriptions are made; and be used for the treatment of the medicine of premature ovarian failure, all belong to the scope of the application's protection.
6, conclusion
Component science of the present invention, abundant raw material, cheap, reasonable compatibility, mutual support, effect of nourishing YIN and benefiting blood, enriching kidney essence, dispersing the stagnated live-QI to relieve the stagnation of QI, nourshing blood and promoting blood circulation played altogether by all medicines, is effective to treat premature ovarian failure, good effect, drug safety, effective percentage, up to more than 93%, is that one on Chinese medicine is innovated greatly, has actual clinical meaning.
Claims (5)
1. treat the Chinese medicine of premature ovarian failure for one kind, it is characterized in that, be made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 5-20 part, Fructus Lycii 5-20 part, Colla Corii Asini 3-12 part, Fructus Rubi 5-25 part, Placenta Hominis 1-5 part, Gecko 3-10 part, Cordyceps 5-15 part, Radix Curcumae 5-15 part, Fructus Akebiae 10-30 part, Radix Angelicae Sinensis 5-20 part, Radix Salviae Miltiorrhizae 10-20 part and Fructus Leonuri 3-10 part.
2. the Chinese medicine for the treatment of premature ovarian failure according to claim 1, it is characterized in that, be made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 6 parts, Fructus Lycii 19 parts, 4 parts, Colla Corii Asini, Fructus Rubi 24 parts, Placenta Hominis 2 parts, Gecko 9 parts, Cordyceps 6 parts, Radix Curcumae 14 parts, Fructus Akebiae 11 parts, Radix Angelicae Sinensis 19 parts, Radix Salviae Miltiorrhizae 11 parts and Fructus Leonuri 9 parts.
3. the Chinese medicine for the treatment of premature ovarian failure according to claim 1, it is characterized in that, be made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 12 parts, Fructus Lycii 13 parts, 7 parts, Colla Corii Asini, Fructus Rubi 15 parts, Placenta Hominis 3 parts, Gecko 6 parts, Cordyceps 10 parts, Radix Curcumae 10 parts, Fructus Akebiae 20 parts, Radix Angelicae Sinensis 12 parts, Radix Salviae Miltiorrhizae 15 parts and Fructus Leonuri 7 parts.
4. the Chinese medicine for the treatment of premature ovarian failure according to claim 1, it is characterized in that, be made up of the material medicine of following weight parts: Fructus Ligustri Lucidi 19 parts, Fructus Lycii 6 parts, 11 parts, Colla Corii Asini, Fructus Rubi 6 parts, Placenta Hominis 4 parts, Gecko 4 parts, Cordyceps 14 parts, Radix Curcumae 6 parts, Fructus Akebiae 29 parts, Radix Angelicae Sinensis 6 parts, Radix Salviae Miltiorrhizae 19 parts and Fructus Leonuri 4 parts.
5. the Chinese medicine of claim 1 or the treatment premature ovarian failure described in any one of 2-4, preparation method can make any one in decoction, powder, tablet, granule, pill, capsule or oral liquid routinely.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104906526A (en) * | 2015-07-14 | 2015-09-16 | 孙海玲 | Chinese medicine preparation for premature ovarian failure and preparation method of Chinese medicine preparation |
| CN105943651A (en) * | 2016-06-27 | 2016-09-21 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating premature ovarian failure, and application thereof |
| CN111419992A (en) * | 2019-01-10 | 2020-07-17 | 四川省中医药科学院 | Composition for delaying ovarian senescence and preparation method and application thereof |
| CN113456723A (en) * | 2020-03-30 | 2021-10-01 | 东莞市东阳光冬虫夏草研发有限公司 | Pharmaceutical composition and use thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906526A (en) * | 2015-07-14 | 2015-09-16 | 孙海玲 | Chinese medicine preparation for premature ovarian failure and preparation method of Chinese medicine preparation |
| CN105943651A (en) * | 2016-06-27 | 2016-09-21 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating premature ovarian failure, and application thereof |
| CN105943651B (en) * | 2016-06-27 | 2019-10-01 | 上海中医药大学附属岳阳中西医结合医院 | A kind of Chinese medicine composition that treating premature ovarian failure and its application |
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| CN113456723A (en) * | 2020-03-30 | 2021-10-01 | 东莞市东阳光冬虫夏草研发有限公司 | Pharmaceutical composition and use thereof |
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