CN104189034A - External patch with muscle and bone soothing effect and preparation method of external patch - Google Patents
External patch with muscle and bone soothing effect and preparation method of external patch Download PDFInfo
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Abstract
The invention discloses an external patch with a muscle and bone soothing effect as well as a preparation method and application of the external patch. The external patch with the muscle and bone soothing effect is provided with a backing layer, an ointment-containing body and a protective layer, wherein the ointment-containing body is prepared by mixing a traditional Chinese medicine extract, a matrix and a crosslinking agent, and the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 200-800 parts of sargentodoxa cuneata, 100-500 parts of ligusticum chuanxiong, 100-300 parts of achyranthes bidentata, 100-700 parts of lycopodii herbs and 50-200 parts of borneol. The invention also provides the preparation method of the external traditional Chinese medicine patch. The patch has the health-care effects of promoting blood circulation to remove meridian obstruction, eliminating cold to stop pain, promoting the rehabilitation of bone and joint parts, relieving pain and discomfort at parts such as necks, shoulders, waists and knees and promoting the rehabilitation of the parts. Compared with the prior art, the external patch is safe in use, exact in curative effect and simple in prescription; and the preparation method is simple in process and suitable for large-scale industrial production.
Description
Technical field
The present invention relates to a kind of Chinese herbs paste for promoting blood circulation to remove obstruction in the collateral, mass dissipating and swelling eliminating, particularly logical external use plaster of an analgesic bone and its preparation method and application.
Technical background
Arthralgia, numb limbs and tense tendons, paraesthesia etc. are the common comprehensive Signs at limbs and osteoarthrosis position, how by many reasons such as rheumatism cold-evil, hyperosteogeny, osteoarticular retrograde affections, to be caused.Although the many differences of its cause of disease, its Symptoms is roughly similar.Clinical data shows, at the sickness rate of China, up to 20% left and right, especially, in 40 years old above mid-aged population, sickness rate can reach 42%.And all the year round in underground work, stand for a long time, its sickness rate is higher in the people of field and severe cold humid area Working Life.Disease is once generate, and it is agonizing, has a strong impact on patient's healthy living quality.Therefore to slow down limbs and osteoarthrosis position pain and uncomfortable external use health articles for use be to solve the important topic that health of people is badly in need of in research, has larger market prospect.
The research for the treatment of joint disease is more and more at present, as patent CN200710173341.6, name are called medicine for the treatment of osteoarthritis and preparation method thereof, disclose by 29 kinds of externally used pastes that Chinese crude drug is made such as Radix Clematidis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopodii, Caulis Sargentodoxae, the Chinese crude drug of its use is of a great variety, and each medical material consumption is without significant difference, cause determining the monarch of compatibility of drugs, also just cannot determine it is which kind of medicine performance Main Function actually, and because kind is too much, also can cause that impurity increase, medicine influence each other etc.; The Chinese medicine preparation of the outstanding and hypertrophy of patent application CN201310204439.1, treatment human cervical spine, lumbar vertebra and for example, discloses by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, Herba Lycopodii 85 kinds of products that medical material is made totally; Also have patent CN200810047135.8, there is rheumatism involving the bone disease plaster of expelling wind and dampness, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain and preparation method thereof, disclose by 19 kinds of unguentum that medical material is made such as Rhizoma Chuanxiong, Radix Stephaniae Tetrandrae, Olibanum, Cortex Phellodendri, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentataes.Said medicine has all been brought into play certain therapeutical effect, but has too the defects such as weight is various, principal agent is difficult to determine, medicine influences each other.In addition, the arthropathic listing product category for health care of existing treatment is more, but mostly is rubber-emplastrum, and the chemistry such as Western medicine or Borneolum Syntheticum, Mentholum of take facilitate product or the pungent cool Chinese medicine of dispersing as main, and content of dispersion is few, easily distribute inefficacy.
In recent years, local characteristic national medicine articles for use are more and more subject to people's concern and favor, this research worker is by investigation and exploration to the local characteristic Miao Ethnomedicine in Guizhou, by several, among the peoplely with medical material, carry out compatibility repeatedly and a large amount of experimentatioies, be surprised to find, by the formulated product of the medical materials such as the characteristic medicines such as the Caulis Sargentodoxae of locality, Guizhou, Herba Lycopodii and Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, treatment bones and muscles pain, promoting blood circulation to remove obstruction in the collateral are had to extraordinary curative effect, and prescription is simple, processing technology is easy, be suitable for industrialized great production.
Summary of the invention
The object of the invention is to the logical external use plaster of muscles and bones that provide a kind of determined curative effect, prescription is simple, processing technology is easy, is suitable for industrialized great production.
It is raw material that the logical external use plaster of muscles and bones of the present invention be take the vegetable drug that Miao in Guizhou commonly uses, according to its effective ingredient, pharmacological action etc., through science processing, be prepared from, the external use health articles for use of making in line with the principle of health-care recovery, the logical Seedling of called after muscles and bones pastes, product of the present invention is given full play to external application and is convenient to local absorption, easy to use, the acceptable advantage of patient, has the health-care effect of the rehabilitation at good promoting blood circulation to remove obstruction in the collateral, dispersing cold for relieving pain, promotion osteoarthrosis position.Technical scheme is as follows:
One analgesic bone is led to external use plaster; it is provided with backing layer, ointment-containing body and protective layer; described ointment-containing body is to be mixed by Chinese medical concrete, substrate and cross-linking agent, it is characterized in that: described Chinese medical concrete is made by the raw material of following percentage by weight: Caulis Sargentodoxae 200-800 part, Rhizoma Chuanxiong 100-500 part, Radix Achyranthis Bidentatae 100-300 part, Herba Lycopodii 100-700 part, Borneolum Syntheticum 50-200 part.
Specifically, described Chinese medical concrete is made by the raw material of following percentage by weight: 500 parts of Caulis Sargentodoxae, 300 parts of Rhizoma Chuanxiongs, 200 parts of Radix Achyranthis Bidentataes, 400 parts of Herba Lycopodiis, 100 parts of Borneolum Syntheticums.
Described substrate is to be mixed by micropowder silica gel, calcium carbonate, glycerol, sodium alginate and gelatin.
In described ointment-containing body, each component and weight portion thereof are: Chinese medical concrete 2-6 part, micropowder silica gel 6-12 part, calcium carbonate 10-20 part, glycerol 5-15 part, sodium alginate 2-8 part, gelatin 4-10 part, titanium dioxide 0.5-2 part.
The preparation method that the invention also discloses the logical external use plaster of a described analgesic bone, is characterized in that: step is as follows:
(1) preparation of Chinese medical concrete: by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae and Herba Lycopodii remove impurity respectively, dry, then be ground into coarse powder, cross 40 mesh sieves, by formula, measure above-mentioned raw materials, respectively by 5-8 40-60% alcohol dipping doubly 2-4 time, each 4 days, merge impregnation liquid, filter, the extractum that during 60 ℃ of filtrate simmer down tos, relative density is 1.15-1.20, add formula ratio to cross the Borneolum Syntheticum of 60-80 mesh sieve, mix homogeneously;
(2) preparation of substrate: the micropowder silica gel of formula ratio described in ointment-containing body, calcium carbonate, glycerol are added to sodium alginate, gelatin after mixing, stir;
(3) preparation of ointment-containing body: add the Chinese medical concrete of formula ratio described in ointment-containing body prepared by step (1) in the substrate of preparing to step (2), add titanium dioxide simultaneously, under room temperature, rotating speed is that 50-70rpm/min stirs 30-50min, obtains;
(4) finished product preparation: the ointment-containing body that step (3) is made is coated on backing layer and protective layer, room temperature is placed 18-24h, and section, packs and get final product.
Described step step (3) medium speed is 60rpm/min, and mixing time is 40min;
In described step (4), be 24h standing time.
The invention also discloses the logical external use plaster of described muscles and bones is preparing promoting blood circulation to remove obstruction in the collateral, mass dissipating and swelling eliminating, is preventing and treating the application in bones and muscles pain medicine.
Each composition characteristic and effect thereof that the present invention uses are as follows:
Caulis Sargentodoxae: Latin formal name used at school: Sargentodoxa cuneata (Oliv.) Rehd.et Wils..Nature and flavor are bitter, flat.Return large intestine, Liver Channel.There is heat-clearing and toxic substances removing, invigorate blood circulation, wind-expelling pain-stopping., for tumbling and swelling, rheumatic arthralgia etc.
Herba Lycopodii: be the herb of Lycopodiaceae Lycopodium plant Lycopodium clavatum Lycopodium japonicum Thunb., the micro-hardship of property, pungent, warm.Return liver,spleen,kidney warp.Effect: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Rhizoma Chuanxiong: formal name used at school: Ligusticum chuanxiong, acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping, for pacifying nerve, tumbling and swelling, headache, rheumatic arthralgia.In we, as wind-expelling pain-stopping medicine, use.
Radix Achyranthis Bidentatae: formal name used at school: Achyranthes bidentata, nature and flavor are sweet, bitter, sour, flat, return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation.Invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable.
Borneolum Syntheticum: formal name used at school: Dipterocarpaceae, nature and flavor are pungent, bitter, be slightly cold.GUIXIN, spleen, lung meridian.There is the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain effect.
More than comprehensive, it is monarch drug that Caulis Sargentodoxae, Rhizoma Chuanxiong be take in full side, embody invigorate blood circulation active, wind-expelling pain-stopping effect; Herba Lycopodii, Radix Achyranthis Bidentatae, Borneolum Syntheticum are ministerial drug, and all medicines share and help its blood circulation promoting and blood stasis dispelling, and bone and muscle strengthening, stopping numbness pain effect, jointly to reach promoting blood circulation to remove obstruction in the collateral, the effect of mass dissipating and swelling eliminating.Therefore external use plaster of the present invention, to the pain at the positions such as cervical region, shoulder, waist, knee joint and the uncomfortable health-care effect that has alleviation and promote rehabilitation, is used safely, has no side effect.In addition, external use plaster viscosity of the present invention is good, permeability is good, non-stimulated and allergic phenomena, and patient compliance is good, can adhere to for a long time using.The Chinese crude drug of its use adopts locality, Guizhou to produce Miao Ethnomedicine, has the advantages such as geographical conditions are superior, medical material active constituent content is high, and medical material kind is few, cost is low, preparation technology's advantages of simple, has broad application prospects.
The specific embodiment:
In order to make those of ordinary skills better understand the present invention, the applicant has carried out series of experiment research, to prove effect of the present invention:
Preparation Example
Embodiment 1
Backing layer: non-woven fabrics; Protective layer: polyester film;
Ointment-containing body forms: Chinese medical concrete 400g, micropowder silica gel 900g, calcium carbonate 1500g, glycerol 1000g, sodium alginate 500g, gelatin 700g, titanium dioxide 100g;
Preparation method: the preparation of (1) Chinese medical concrete: by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae and Herba Lycopodii remove impurity respectively, dry, then be ground into coarse powder, cross 40 mesh sieves, get above-mentioned Caulis Sargentodoxae 500g, Rhizoma Chuanxiong 300g, Radix Achyranthis Bidentatae 200g and Herba Lycopodii 400g, use respectively 50% alcohol dipping 3 times of 6 times, each 4 days, merge impregnation liquid, filter, the extractum that during 60 ℃ of filtrate simmer down tos, relative density is 1.20, add the Borneolum Syntheticum 100g that crosses 80 mesh sieves, mix homogeneously;
(2) preparation of substrate: the micropowder silica gel of formula ratio described in ointment-containing body, calcium carbonate, glycerol are added to sodium alginate, gelatin after mixing, stir;
(3) preparation of ointment-containing body: the Chinese medical concrete 400g that adds step (1) to prepare in the substrate of preparing to step (2), add titanium dioxide 100g simultaneously, under room temperature, rotating speed is that 60rpm/min stirs 40min, obtains;
(4) finished product preparation: the ointment-containing body that step (3) is made is coated on backing layer and protective layer, room temperature is placed 24h, and section is packed and is obtained external use plaster 1000 and pastes.
Embodiment 2
Backing layer: non-woven fabrics; Protective layer: polyethylene film;
Ointment-containing body forms: Chinese medical concrete 200g, micropowder silica gel 1200g, calcium carbonate 1000g, glycerol 1500g, sodium alginate 200g, gelatin 1000g, titanium dioxide 50g;
Preparation method: the preparation of (1) Chinese medical concrete: by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae and Herba Lycopodii remove impurity respectively, dry, then be ground into coarse powder, cross 40 mesh sieves, get above-mentioned Caulis Sargentodoxae 200g, Rhizoma Chuanxiong 100g, Radix Achyranthis Bidentatae 100g and Herba Lycopodii 100g, use respectively 60% alcohol dipping 2 times of 5 times, each 4 days, merge impregnation liquid, filter, the extractum that during 60 ℃ of filtrate simmer down tos, relative density is 1.15, add the Borneolum Syntheticum 50g that crosses 60 mesh sieves, mix homogeneously;
(2) preparation of substrate: the micropowder silica gel of formula ratio described in ointment-containing body, calcium carbonate, glycerol are added to sodium alginate, gelatin after mixing, stir;
(3) preparation of ointment-containing body: the Chinese medical concrete 200g that adds step (1) to prepare in the substrate of preparing to step (2), add titanium dioxide 50g simultaneously, under room temperature, rotating speed is that 50rpm/min stirs 50min, obtains;
(4) finished product preparation: the ointment-containing body that step (3) is made is coated on backing layer and protective layer, room temperature is placed 18h, and section, packs and get final product.
Embodiment 3
Backing layer: artificial cloth; Protective layer: separate paper;
Ointment-containing body forms: Chinese medical concrete 600g, micropowder silica gel 600g, calcium carbonate 2000g, glycerol 500g, sodium alginate 800g, gelatin 400g, titanium dioxide 200g;
Preparation method: the preparation of (1) Chinese medical concrete: by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae and Herba Lycopodii remove impurity respectively, dry, then be ground into coarse powder, cross 40 mesh sieves, get above-mentioned Caulis Sargentodoxae 800g, Rhizoma Chuanxiong 500g, Radix Achyranthis Bidentatae 300g and Herba Lycopodii 700g, use respectively 40% alcohol dipping 4 times of 8 times, each 4 days, merge impregnation liquid, filter, the extractum that during 60 ℃ of filtrate simmer down tos, relative density is 1.20, add the Borneolum Syntheticum 200g that crosses 80 mesh sieves, mix homogeneously;
(2) preparation of substrate: the micropowder silica gel of formula ratio described in ointment-containing body, calcium carbonate, glycerol are added to sodium alginate, gelatin after mixing, stir;
(3) preparation of ointment-containing body: the Chinese medical concrete 600g that adds step (1) to prepare in the substrate of preparing to step (2), add titanium dioxide 200g simultaneously, under room temperature, rotating speed is that 70rpm/min stirs 30min, obtains;
(4) finished product preparation: the ointment-containing body that step (3) is made is coated on backing layer and protective layer, room temperature is placed 20h, and section, packs and get final product.
Embodiment 4 (low content of dispersion)
Backing layer: non-woven fabrics; Protective layer: polyester film;
Ointment-containing body forms: Chinese medical concrete 150g, micropowder silica gel 900g, calcium carbonate 1800g, glycerol 1200g, sodium alginate 500g, gelatin 620g, titanium dioxide 80g;
Preparation method: the preparation of (1) Chinese medical concrete: by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae and Herba Lycopodii remove impurity respectively, dry, then be ground into coarse powder, cross 40 mesh sieves, get above-mentioned Caulis Sargentodoxae 250g, Rhizoma Chuanxiong 150g, Radix Achyranthis Bidentatae 100g and Herba Lycopodii 200g, use respectively 55% alcohol dipping 3 times of 7 times, each 4 days, merge impregnation liquid, filter, the extractum that during 60 ℃ of filtrate simmer down tos, relative density is 1.15, add the Borneolum Syntheticum 50g that crosses 60 mesh sieves, mix homogeneously;
(2) preparation of substrate: the micropowder silica gel of formula ratio described in ointment-containing body, calcium carbonate, glycerol are added to sodium alginate, gelatin after mixing, stir;
(3) preparation of ointment-containing body: the Chinese medical concrete 150g that adds step (1) to prepare in the substrate of preparing to step (2), add titanium dioxide 80g simultaneously, under room temperature, rotating speed is that 60rpm/min stirs 40min, obtains;
(4) finished product preparation: the ointment-containing body that step (3) is made is coated on backing layer and protective layer, room temperature is placed 24h, and section, packs and get final product.
Embodiment 5 (high content of dispersion)
Backing layer: non-woven fabrics; Protective layer: separate paper;
Ointment-containing body forms: Chinese medical concrete 700g, micropowder silica gel 800g, calcium carbonate 1200g, glycerol 800g, sodium alginate 700g, gelatin 800g, titanium dioxide 100g;
Preparation method: the preparation of (1) Chinese medical concrete: by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae and Herba Lycopodii remove impurity respectively, dry, then be ground into coarse powder, cross 40 mesh sieves, get above-mentioned Caulis Sargentodoxae 900g, Rhizoma Chuanxiong 600g, Radix Achyranthis Bidentatae 400g and Herba Lycopodii 800g, use respectively 50% alcohol dipping 3 times of 6 times, each 4 days, merge impregnation liquid, filter, the extractum that during 60 ℃ of filtrate simmer down tos, relative density is 1.20, add the Borneolum Syntheticum 300g that crosses 60 mesh sieves, mix homogeneously;
(2) preparation of substrate: the micropowder silica gel of formula ratio described in ointment-containing body, calcium carbonate, glycerol are added to sodium alginate, gelatin after mixing, stir;
(3) preparation of ointment-containing body: the Chinese medical concrete 700g that adds step (1) to prepare in the substrate of preparing to step (2), add titanium dioxide 100g simultaneously, under room temperature, rotating speed is that 60rpm/min stirs 40min, obtains;
(4) finished product preparation: the ointment-containing body that step (3) is made is coated on backing layer and protective layer, room temperature is placed 24h, and section, packs and get final product.
The clinical observation test of effect experiment example external use plaster treatment of the present invention neck, shoulder, waist, knee position pain
1, physical data:
225 routine patients are all outpatient.Male 138 examples wherein, female's 87 examples; Age 22-69 year; The course of disease 3 days-15 years; Cervical spondylosis 48 examples, scapulohumeral periarthritis 44 examples, lumbar spondylosis 55 examples, knee joint rheumatalgia 47 examples, other traumatic injury pain 31 examples.
2, diagnostic criteria:
Through hospital's film making or trauma diagnosis, make a definite diagnosis.Get rid of skin allergy person.
3, criterion of therapeutical effect:
Effective: the symptoms such as pain disappear substantially, it is normal that functional activity recovers substantially;
Effective: pain relief, functional activity improves;
Invalid: before and after treatment, pain, functional activity obstacle are unchanged.
4, Therapeutic Method
4.1 medicines:
Sample 1-5: the patch of making according to embodiment of the present invention 1-5,5g/ pastes; Control sample 1: unblocking collaterals to treat arthritis pastes, Jilin Wan Tong Pharmaceutical group produces; Plaster prepared by control sample 2:CN200810047135.8 embodiment 1 method.
4.2 test method
225 routine patients are divided into 7 groups at random, and sample 1-3 organizes and control sample 1-2 group, every group of 35 examples, sample 4-5 group, every group of 25 examples.Each organizes experimenter's basic condition, age, the course of disease there are no significant difference.Sample is sticked in affected part, paste, within 24 hours, change dressings for one time 1.Above-mentioned sample is used after 4 weeks and checks continuously.Anemia of pregnant woman, women breast-feeding their children, skin allergy person should not use.
5, result of the test
5.1 treatment necks, shoulder, waist, knee position Pain test result (in Table 1-5)
The comparison of table 1 treatment cervical spondylosis effect
The comparison of table 2 cure scapulohumeral periarthritis effect
The comparison of table 3 treatment lumbar spondylosis effect
The comparison of table 4 treatment knee joint rheumatalgia effect
The comparison of table 5 treatment traumatic injury pain effect
5.2 safeties are investigated: except sample 5, all none examples of tested patient have the obviously poisoning symptom such as redness, ulceration, erosion, external haemorrhage and suppuration.Use the some patients were of sample 5 to occur the poisoning symptoms such as slight ulceration, suppuration, after prompting content of dispersion height, because drug level is too concentrated, can cause certain toxicity.Therefore do not advise adopting the formula of high medicament contg.
Experimental result shows: experimenter uses patch of the present invention after 4 weeks continuously, more than 80% experimenter's pain relief or substantially disappearance, functional activity improves even basic recovery normally, total effective rate of the present invention reaches more than 83.3%, wherein treat traumatic injury, rheumatic arthritis effective percentage reaches 100%, and corresponding affected part, without red and swollen, the obviously poisoning symptom such as fester, illustrates that Seedling of the present invention pastes determined curative effect and uses safety.Compare with comparative sample 1,2, obvious effective rate and effective percentage are all improved, and have clear superiority.In addition, adopt sample 4 therapeutic effect of the low content of dispersion of the present invention undesirable, and sample 5 curative effects of high content of dispersion are not significantly improved and have mild toxicity, illustrate safe and effective within the scope of prescription of the present invention and fill a prescription rationally.
Claims (7)
1. an analgesic bone is led to external use plaster; it is provided with backing layer, ointment-containing body and protective layer; described ointment-containing body is to be mixed by Chinese medical concrete, substrate and cross-linking agent, it is characterized in that: described Chinese medical concrete is made by the raw material of following percentage by weight: Caulis Sargentodoxae 200-800 part, Rhizoma Chuanxiong 100-500 part, Radix Achyranthis Bidentatae 100-300 part, Herba Lycopodii 100-700 part, Borneolum Syntheticum 50-200 part.
2. according to the logical external use plaster of muscles and bones claimed in claim 1, it is characterized in that: described Chinese medical concrete is made by the raw material of following percentage by weight: 500 parts of Caulis Sargentodoxae, 300 parts of Rhizoma Chuanxiongs, 200 parts of Radix Achyranthis Bidentataes, 400 parts of Herba Lycopodiis, 100 parts of Borneolum Syntheticums.
3. the logical external use plaster of muscles and bones as claimed in claim 1 or 2, is characterized in that: described substrate is to be mixed by micropowder silica gel, calcium carbonate, glycerol, sodium alginate and gelatin.
4. the logical external use plaster of muscles and bones as claimed in claim 3, is characterized in that: in described ointment-containing body, each component and weight portion thereof are: Chinese medical concrete 2-6 part, micropowder silica gel 6-12 part, calcium carbonate 10-20 part, glycerol 5-15 part, sodium alginate 2-8 part, gelatin 4-10 part, titanium dioxide 0.5-2 part.
5. a preparation method for the logical external use plaster of muscles and bones as described in as arbitrary in claim 1-4, is characterized in that: step is as follows:
(1) preparation of Chinese medical concrete: by Caulis Sargentodoxae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae and Herba Lycopodii remove impurity respectively, dry, then be ground into coarse powder, cross 40 mesh sieves, by formula, measure above-mentioned raw materials, respectively by 5-8 40-60% alcohol dipping doubly 2-4 time, each 4 days, merge impregnation liquid, filter, the extractum that during 60 ℃ of filtrate simmer down tos, relative density is 1.15-1.20, add formula ratio to cross the Borneolum Syntheticum of 60-80 mesh sieve, mix homogeneously;
(2) preparation of substrate: the micropowder silica gel of formula ratio described in ointment-containing body, calcium carbonate, glycerol are added to sodium alginate, gelatin after mixing, stir;
(3) preparation of ointment-containing body: add the Chinese medical concrete of formula ratio described in ointment-containing body prepared by step (1) in the substrate of preparing to step (2), add titanium dioxide simultaneously, under room temperature, rotating speed is that 50-70rpm/min stirs 30-50min, obtains;
(4) finished product preparation: the ointment-containing body that step (3) is made is coated on backing layer and protective layer, room temperature is placed 18-24h, and section, packs and get final product.
6. preparation method as claimed in claim 5, is characterized in that: described step step (3) medium speed is 60rpm/min, and mixing time is 40min; In described step (4), be 24h standing time.
7. the external use plaster as described in as arbitrary in claim 1-4 is being prepared promoting blood circulation to remove obstruction in the collateral, mass dissipating and swelling eliminating, is being prevented and treated the application in bones and muscles pain medicine.
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| CN105770168A (en) * | 2016-03-23 | 2016-07-20 | 李世豪 | Medicinal liquor for treating traumatic injury and method for preparing medicinal liquor |
| CN107854530A (en) * | 2017-11-15 | 2018-03-30 | 北京光仁堂生物科技有限公司 | One analgesic bone dredging collateral patch and preparation method thereof |
| CN107854530B (en) * | 2017-11-15 | 2020-11-13 | 北京光仁堂生物科技有限公司 | Muscle and bone collateral-dredging patch and preparation method thereof |
| CN108295164A (en) * | 2018-02-10 | 2018-07-20 | 广西中医药大学 | A kind of graphene rheumatoid arthrosis pain patch and preparation method thereof |
| CN108686164A (en) * | 2018-07-05 | 2018-10-23 | 深圳市和普利科技有限公司 | A kind of tumour external plaster and preparation method thereof |
| CN108904623A (en) * | 2018-07-05 | 2018-11-30 | 深圳市和普利科技有限公司 | A kind of fat-reducing plaster and preparation method thereof |
| CN108686038A (en) * | 2018-08-07 | 2018-10-23 | 北京冼荣华中医药研究院 | A kind of bruise massage oil and preparation method thereof |
| CN115671159A (en) * | 2021-12-24 | 2023-02-03 | 王鑫 | Muscle and bone plaster |
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