CN104524331B

CN104524331B - Prevent the drug of mumps

Info

Publication number: CN104524331B
Application number: CN201410807662.XA
Authority: CN
Inventors: 林晶
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-23
Filing date: 2014-12-23
Publication date: 2018-06-22
Anticipated expiration: 2034-12-23
Also published as: CN104524331A

Abstract

The present invention provides for preventing the endo-medicine of mumps and liniment, the bulk pharmaceutical chemicals of endo-medicine include cape jasmine, Radix Isatidis, safflower, Selaginella tamariscina, prepared rehmannia root, Caulis Spatholobi, root of Twelve stamen Melastoma, foliosous parnassia herb, Chinese yam, radix scrophulariae, coix seed, mistletoe, motherwort, giant knotweed and Radix Glycyrrhizae, and the bulk pharmaceutical chemicals of liniment include cloud sedge, benbie, bush, schizonepeta, Rabdosia rubescens, the root bark of white mulberry, caulis piperis futokadsurae, cattail pollen, felwort and Poria cocos.By being used in combination endo-medicine and liniment, infant no pain is resourceful, economical, and has no adverse reaction during being administered, and is worthy of popularization.

Description

Prevent the drug of mumps

Technical field

The present invention relates to technical field of Chinese medicine more particularly to a kind of medicines for preventing mumps and its complication Object.

Background technology

The mumps referred to as stream cheek, is the common acute respiratory infectious disease as caused by mumps virus, Characterized by the apyetous swelling of the parotid gland and pain, other glandular tissues of whole body can also be involved.Mumps virus is by suffering from Person and the saliva of healthy carrier or respiratory tract juice spittle air-borne transmission.Infection prevalence can all occur for whole year, every about 2 Primary prevalence occurs within~5 years, can obtain lifetime immunity, but individual antibody low SI person after most of patients single infection, also may be used Subinfection again.Symptoms are mild for parotitis, and meningitis, orchitis and oaritis etc. often occur after infection for 5~9 years old incidence highest Complication, and encephalitis and permanent neurologic system sequelae are rare complication, the most of areas in the whole world, are connect if not carrying out vaccine Kind, mumps incidence is 100/100,000~1000/100,000.

Mumps is mainly shown as enlargement under the ear-lobe of one or both sides, and the parotid gland of enlargement is often hemispherical, with ear Centered on hanging down, blur margin, surface heat has tenderness, dehisces or locally feels pain when chewing.

It is more using virazole in being treated on western medicine, viral polymerase activity can be inhibited, the virus of blocking dna is answered System, it is effective to a variety of DNA and RNA virus, but side reaction is more.

Motherland's this disease of medicine is referred to as mumps, Jin Dynasty Dou Jie《Sore experience pandect parotid glands poison》：" parotid gland poison is by the basal part of the ear, ear Ting, by liver kidney, qi and blood does not flow, and stops up the stagnant cheek cheek, this is wind toxin disease." for the disease cause of disease to experience parotid gland virus, heresy invades liver and gall two Through treatment is when with treating both manifestation and root cause of disease.This disease cause of disease be diseases caused by external factors wind-warm syndrome cult poison, enter from mouth and nose, stop up resistance the gallbladder channel of foot-Shaoyang, it is strongly fragrant without It dissipates, ties and fall ill in cheek;Few sun is fainted with foot in cloudy table each other, and the arteries and veins of the moon of fainting enough follows few abdomen hernia and colic, if by evil heavier, compared with Big children can concurrent hypogastric pain, testiclar gall, with clearing heat and detoxicating in prevention, dissipating bind stagnation resolvation, inducing diuresis and reducing edema is principle.Chinese medicine is controlled It is preferable to treat this sick prognosis, and forms antibody, lifetime immunity.

Using oral medicinal herb and external application for curing mumps, infant no pain is resourceful, economical, and administration phase Between have no adverse reaction, be worthy of popularization.

Invention content

The technical problems to be solved by the invention are to provide a kind of for preventing the interior of mumps and its complication Medication object and liniment, infant no pain is resourceful, economical, and has no adverse reaction during being administered, and is worthy of popularization.

In order to solve the above technical problems, the present invention provides a kind of for preventing the endo-medicine of mumps, Bulk pharmaceutical chemicals include cape jasmine, Radix Isatidis, safflower, Selaginella tamariscina, prepared rehmannia root, Caulis Spatholobi, root of Twelve stamen Melastoma, foliosous parnassia herb, Chinese yam, radix scrophulariae, coix seed, Mistletoe, motherwort, giant knotweed and Radix Glycyrrhizae.

Wherein, the weight of each bulk pharmaceutical chemicals of the endo-medicine is respectively cape jasmine 35g ~ 45g, Radix Isatidis 50g ~ 60g, safflower 25g ~ 35g, Selaginella tamariscina 25g ~ 35g, prepared rehmannia root 10g ~ 20g, Caulis Spatholobi 20g ~ 30g, root of Twelve stamen Melastoma 10g ~ 20g, foliosous parnassia herb 15g ~ 25g, Chinese yam 20g ~ 30g, radix scrophulariae 15g ~ 25g, coix seed 20g ~ 30g, mistletoe 15g ~ 25g, motherwort 20g ~ 30g, giant knotweed 30g ~ 40g With Radix Glycyrrhizae 15g ~ 25g.

Wherein, the weight of each bulk pharmaceutical chemicals of the endo-medicine is respectively cape jasmine 38g ~ 42g, Radix Isatidis 53g ~ 57g, safflower 28g ~ 32g, Selaginella tamariscina 23g ~ 27g, prepared rehmannia root 13g ~ 17g, Caulis Spatholobi 23g ~ 27g, root of Twelve stamen Melastoma 13g ~ 17g, foliosous parnassia herb 18g ~ 22g, Chinese yam 23g ~ 27g, radix scrophulariae 18g ~ 22g, coix seed 23g ~ 27g, mistletoe 18g ~ 22g, motherwort 23g ~ 27g, giant knotweed 33g ~ 37g With Radix Glycyrrhizae 18g ~ 22g.

The endo-medicine is prepared into decoction.

The present invention also provides the preparation methods of above-mentioned decoction, specially add in above-mentioned raw materials medicine in container, to container In pour into the water relative to 6~8 times of amounts of each bulk pharmaceutical chemicals quality sum, after impregnating 2~3 hours, boil 3~4 hours, extract, then It is secondary to add in relative to each 4~6 times of amount water of bulk pharmaceutical chemicals quality sum, it boils 2~3 hours, extracts, finally, add in relative to each original Expect 3~5 times of amount water of medicine quality sum, heating is boiled 1~2 hour, extracted；Merge extracting solution three times, filtering obtains filtrate, depressurizes Part water is removed, obtains the decoction of 1g (crude drug)/ml.

The present invention also provides for preventing the liniment of mumps, bulk pharmaceutical chemicals include cloud sedge, Bao Gai Grass, bush, schizonepeta, Rabdosia rubescens, the root bark of white mulberry, caulis piperis futokadsurae, cattail pollen, felwort and Poria cocos.

Wherein, the weight of each bulk pharmaceutical chemicals is respectively cloud sedge 15g ~ 25g, benbie 20g ~ 30g, Soviet Union in the liniment Wooden 15g ~ 25g, schizonepeta 1g ~ 10g, Rabdosia rubescens 10g ~ 20g, root bark of white mulberry 15g ~ 25g, caulis piperis futokadsurae 10g ~ 20g, cattail pollen 35g ~ 45g, dragon Courage grass 15g ~ 25g and Poria cocos 20g ~ 30g.

Wherein, the weight of each bulk pharmaceutical chemicals is respectively cloud sedge 18g ~ 22g, benbie 23g ~ 27g, Soviet Union in the liniment Wooden 18g ~ 22g, schizonepeta 3g ~ 7g, Rabdosia rubescens 13g ~ 17g, root bark of white mulberry 18g ~ 22g, caulis piperis futokadsurae 13g ~ 17g, cattail pollen 38g ~ 42g, dragon Courage grass 18g ~ 22g and Poria cocos 23g ~ 27g.

The liniment is prepared into pad pasting.

The present invention also provides the preparation method of above-mentioned pad pasting, specially：

Each bulk pharmaceutical chemicals are added in container, add the determining alcohol relative to each 3~5 times of bulk pharmaceutical chemicals quality sum to be by the first step 70%~80% ethyl alcohol extracts after being heated to reflux 2~4 hours, extracting solution filtering, is further added in the filter residue of acquisition opposite The ethyl alcohol for being 70%~80% in the determining alcohol of each 2~4 times of bulk pharmaceutical chemicals quality sum, is extracted after being heated to reflux 1~2 hour again, Extracting solution filters, and the filtered fluid obtained twice is mixed, is concentrated under reduced pressure, and it is 1.29~1.32 (70 to be concentrated into relative density DEG C) medicinal extract；

Second step in the medicinal extract prepared in the first step, adds in albolene, stirs evenly, be tuned into paste, medicinal extract with it is all in vain The mass ratio of intellectual circle is 1：1.

Beneficial effects of the present invention:

The present invention is provided to prevent the endo-medicine of mumps and its complication and liniment, make infant without Pain, it is resourceful, economical, and have no adverse reaction during being administered, it is worthy of popularization.

The present invention provides for preventing the Chinese medicine composition of mumps, the drug taken including in and external application Drug by inside and outside partner treatment, makes infant no pain, resourceful, economical, and has no adverse reaction during being administered, and is worth It must promote and apply.

Based on this, the present invention provides a kind of for preventing the endo-medicine of mumps, bulk pharmaceutical chemicals include Cape jasmine Son, Radix Isatidis, safflower, Selaginella tamariscina, prepared rehmannia root, Caulis Spatholobi, root of Twelve stamen Melastoma, foliosous parnassia herb, Chinese yam, radix scrophulariae, coix seed, mistletoe, benefit are female Grass, giant knotweed and Radix Glycyrrhizae.

Further, the endo-medicine is only made of above-mentioned raw materials medicine.

The weight of each bulk pharmaceutical chemicals of endo-medicine be respectively cape jasmine 35g ~ 45g, Radix Isatidis 50g ~ 60g, safflower 25g ~ 35g, Selaginella tamariscina 25g ~ 35g, prepared rehmannia root 10g ~ 20g, Caulis Spatholobi 20g ~ 30g, root of Twelve stamen Melastoma 10g ~ 20g, foliosous parnassia herb 15g ~ 25g, Chinese yam 20g ~ 30g, radix scrophulariae 15g ~ 25g, coix seed 20g ~ 30g, mistletoe 15g ~ 25g, motherwort 20g ~ 30g, giant knotweed 30g ~ 40g and sweet Careless 15g ~ 25g.

Further preferably, the weight of each bulk pharmaceutical chemicals of the endo-medicine be respectively cape jasmine 38g ~ 42g, Radix Isatidis 53g ~ 57g, Safflower 28g ~ 32g, Selaginella tamariscina 23g ~ 27g, prepared rehmannia root 13g ~ 17g, Caulis Spatholobi 23g ~ 27g, root of Twelve stamen Melastoma 13g ~ 17g, foliosous parnassia herb 18g ~ 22g, Chinese yam 23g ~ 27g, radix scrophulariae 18g ~ 22g, coix seed 23g ~ 27g, mistletoe 18g ~ 22g, motherwort 23g ~ 27g, giant knotweed 33g ~ 37g and Radix Glycyrrhizae 18g ~ 22g.

Most preferably, the weight of each bulk pharmaceutical chemicals of the endo-medicine is respectively cape jasmine 40g, Radix Isatidis 55g, safflower 30g, Selaginella tamariscina 25g, prepared rehmannia root 15g, Caulis Spatholobi 25g, root of Twelve stamen Melastoma 15g, foliosous parnassia herb 20g, Chinese yam 25g, radix scrophulariae 20g, coix seed 25g, mistletoe 20g, motherwort 25g, giant knotweed 35g and Radix Glycyrrhizae 20g.

Each bulk pharmaceutical chemicals pharmacology is as follows：

Cape jasmine：Latin namegardeniae fructus, bitter is cold in nature, enters the heart, lung, three cokes, there is relieving restlessness purging intense heat, soothing the liver solution Strongly fragrant, clearing heat and promoting diuresis, the effect of cooling blood and hemostasis are mainly used for the vexed uneasiness of the strongly fragrant chest gastral cavity of warm heat disease heat, bother not rather；Liver depression is not relaxed Or Liver Channel has having a dizzy spell for heat, pain in chest and hypochondrium, hot eyes dry throat；Jaundice with damp-heat pathogen；The cards such as the abdominal distention of qi depression to blood stasis.

Radix Isatidis：Latin nameIsatidis Radix,It is bitter, cold in nature, enter the heart, liver, courage, stomach, there is clearing heat and detoxicating, cool blood The effect of relieving sore-throat, for treating febrile virulent maculae；High heat headache；Major part pestilence；Tongue is dark reddish purple dark, scarlet fever；Erysipelas；Mumps；Larynx Numbness；Sore swells, carbuncle swells；Varicella；Measles；Hepatitis；Influenza, epidemic meningitis, encephalitis, pneumonia, coma hematemesis, pharynx swelling, pinkeye, sore Rash；The cards such as Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis can be prevented, Radix Isatidis has various bacteria Inhibiting effect infusions are to hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, typhoid bacillus, paratyphoid bar Bacterium, dysentery（Will is congratulated, Freund）Bacillus, bacillus enteritidis etc. have different degrees of inhibiting effect.

Safflower：Warm-natured, acrid flavour enters, the heart, Liver Channel, has invigorate blood circulation, the effect of stasis-dispelling and pain-killing, for amenorrhoea, and dysmenorrhoea, The cards such as lochia, abdominal mass lump in the abdomen, injury from falling down, sore swell and ache curative.

Selaginella tamariscina：Latin nameSelaginellae Herba, for Spikemoss plant Selaginella tamariscina or the drying herb of Selaginella pulvinata, taste Pungent, mild-natured, Return liver, the heart channel of Hang-Shaoyin have effects that invigorate blood circulation, and for closed dysmenorrhea , wei lump in the abdomen lump in the abdomens, injury from falling down is spitted blood, collapsed Leakage, has blood in stool, the cards such as rectal prolapse.

Prepared rehmannia root：It is sweet in flavor, it is warm-natured, return liver and kidney channel, there is enrich blood moist, the effect of beneficial to spirit and marrow, for blood deficiency chlorosis, Dizziness palpitaition, irregular menstruation collapse more than, liver-kidney Yin deficiency, hectic fever night sweat, impotence of passing out semen, infertility, irregular menstruation, under uterine bleeding Blood, soreness and weakness of waist and knees, Hiccough and deaf is dim-sighted, and poliosis is quenched one's thirst, constipation, the cards such as syndrome characterized by dyspnea.

Caulis Spatholobi：Latin name Spatholobi Caulis, it is bitter, sweet, it is warm-natured, enter liver and kidney channel, there is expansion blood vessel, mend The effect of blood is invigorated blood circulation, menstruation regulating, relaxing tendons and activating collaterals has platelet aggregation apparent inhibiting effect, promotes animal kidney and uterus total Phosphorus metabolism, being mainly used for the treatment deficiency of blood has the irregular menstruation of silt, and limbs pain is meciless, the cards such as soreness and weakness of waist and knees, pain.

Root of Twelve stamen Melastoma：For the root of Genus Melastoma L. of Melastomataceae ground M.-dodecandrum, bitter, micro-sweet is mild-natured, Return liver, lung, the spleen channel, tool Have the effect of promoting blood circulation and hemostasis, eliminating damp, detoxifying, cure mainly promoting menstruation, have difficult labour, postpartum abdominal pain, placenta retension, uterine bleeding, leukorrhea, cough, spit The cards such as blood, dysentery, jaundice, blood strangury, rheumatalgia, toothache, hernia, traumatic injury.

Foliosous parnassia herb：It dashes forward for Saxifragaceae Parnassia plant every the herb or root of star, it is sweet in flavor, it is cold in nature, there is heat-clearing The effect of moistening lung, removing toxicity for detumescence, cures mainly the cards such as pulmonary tuberculosis, laryngitis, parotitis, lymphnoditis, heat toxin sore swells, traumatic injury.

Chinese yam：Latin namedioscoreae rhizoma, it is sweet in flavor, it is mild-natured, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, benefit Stomach kidney tonifying, hearing-improing and eyesight improving, helps the five internal organs, strengthening the bones and muscles, long will to calm the nerves, the effect of promoting longevity at reinforce the kidney beneficial essence, cure mainly it is weakness of the spleen and the stomach, Lassitude, loss of appetite, chronic diarrhea and dysentery, Lung Qi deficiency are dry, phlegm asthma cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence is weak, quench one's thirst Frequent micturition, premature ejaculation of passing out semen, with cards such as the red swollen, obesities of lower gonorrhoea, skin.

Radix scrophulariae：Sweet in flavor, bitter, salty, cold nature, return lung, stomach, kidney channel, with clearing heat and cooling blood, purging intense heat and detonicating, enriching yin is for nourishing kidney Effect cures mainly warm heresy and joins the army, invaginate pericardium, febrile virulent maculae, the deep red polydipsia of consumption of YIN caused by febrile disease, tongue, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, The cards such as pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.

Coix seed：It is cool in nature, sweet in flavor, light, returns spleen, stomach, lung channel.With invigorating the spleen excreting dampness, clearing away heat and eliminating pus, eliminating impediment, Li Shui work( Can, for weakness of the spleen and the stomach, loose stool diarrhea or vaginal discharge diseases of women, insufficiency of the spleen with overabundance of dampness oedema, difficult urination or tinea pedis swell and ache；Damp-heat arthralgia Bitterly, brothers' contraction, miserable pain；Lung carbuncle cough saliva phlegm or enterodynia arrested anxious abdominal pain.

Mistletoe：It is bitter, sweet, it is mild-natured, return liver and kidney channel, there is filling liver kidney, strengthening the bones and muscles, wind-damp dispelling, tocolysis, it is main Control soreness of waist and knee joint；Arthralgia pain due to rheumatism；Fetal irritability；The cards such as blood under threatened abortion.

Motherwort：Bitter, pungent, cold nature, enter liver, pericardium channel, have the effect of promoting blood circulation for regulating menstruation, inducing diuresis to remove edema, cure mainly the moon Through uncomfortable, dysmenorrhoea, Amenorrhea, lochiorrhagia, oedema oliguria, the cards such as acute nephritis edema.

Giant knotweed：Latin name Polygoni Cuspidati Rhizoma et Radix, slight bitter is slightly cold.Return liver, courage, lung Through, have clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, scattered stasis pain, it is relieving cough and reducing sputum the effect of, for joint pain, damp and hot Huang The cards such as subcutaneous ulcer, Amenorrhea , wei lumps in the abdomen, coughing with a lot of sputum, scald, injury from falling down, carbuncle sore tumefacting virus.

Radix Glycyrrhizae：Latin name Glycyrrhizae Radix et Rhizoma, it is sweet in flavor, it is mild-natured, enter 12 warps, there is heat-clearing Removing toxic substances, mediation property of medicine, the effect of expelling phlegm and arresting coughing, and energy invigorating spleen, relieving spasm to stop pain are mainly used for weakness of the spleen and the stomach abdominal distension and receive It is slow-witted, it is weak；Contraction pain in abdomen can be alleviated, mitigate the strong and toxicity of some drugs, mitigate drug to the secondary work of the poison of body With or to gastrointestinal tract stimulation, tonifying Qi can be played the role of by adding in Radix Glycyrrhizae and neutralized, reconcile each component.

The endo-medicine can be prepared into various dosage forms, be preferably prepared to decoction.

Further preferably, the liniment is only made of above-mentioned raw materials medicine.

The weight of each bulk pharmaceutical chemicals is respectively cloud sedge 15g ~ 25g, benbie 20g ~ 30g, bush 15g in the liniment ~ 25g, schizonepeta 1g ~ 10g, Rabdosia rubescens 10g ~ 20g, root bark of white mulberry 15g ~ 25g, caulis piperis futokadsurae 10g ~ 20g, cattail pollen 35g ~ 45g, felwort 15g ~ 25g and Poria cocos 20g ~ 30g.

Further preferably, in the liniment weight of each bulk pharmaceutical chemicals be respectively cloud sedge 18g ~ 22g, benbie 23g ~ 27g, bush 18g ~ 22g, schizonepeta 3g ~ 7g, Rabdosia rubescens 13g ~ 17g, root bark of white mulberry 18g ~ 22g, caulis piperis futokadsurae 13g ~ 17g, cattail pollen 38g ~ 42g, felwort 18g ~ 22g and Poria cocos 23g ~ 27g.

Most preferably, in the liniment weight of each bulk pharmaceutical chemicals be respectively cloud sedge 20g, benbie 25g, bush 20g, Schizonepeta 5g, Rabdosia rubescens 15g, root bark of white mulberry 20g, caulis piperis futokadsurae 15g, cattail pollen 40g, felwort 20g and Poria cocos 25g.

Cloud sedge：It is bitter, pungent for the root or herb of Primulaceae primula Primula efarinsa, it is mild-natured, there is wind-dispelling The effect of dehumidifying, removing toxicity for detumescence, cold, fever is cured mainly, coughed, abscess of throat, toothache, arthralgia pain due to rheumatism, hepatitis, dysentery, stranguria, The cards such as pruitus, venomous snake bite.

Benbie：For the herb of Labiatae lamium plant benbie, acrid flavour, hardship, slightly warm in nature, have it is promoting blood circulation and removing obstruction in channels, The effect of removing toxicity for detumescence, cures mainly traumatic injury, arthralgia and myalgia, numb limb, hemiplegia, facial paralysis, jaundice, nasosinusitis, pyogenic infections, Huang The cards such as water sore.

Bush：Latin namesappan lignum, it is sweet in flavor, salty, it is mild-natured, enter the heart, liver, large intestine channel, there is promoting blood circulation, disappear The effect of swollen analgesic, for cards such as blood stasis amenorrhoea, dysmenorrhoea, postpartum stasis of blood, traumatic injury, fracture carbuncle sore tumefacting virus.

Schizonepeta：The effect of acrid flavour, slightly warm in nature enter lung, Liver Channel, have and expel pathogenic wind from the body surface, the malicious promoting eruption of a surname, regulating blood condition relieving convulsion, cures mainly Flu fever and chills, headache, eye itching, pharyngalgia, cough, measles, rubella, ulcerative carbuncle, brigadier spit blood, and clot blood is had blood in stool, uterine bleeding, postpartum The cards such as apoplexy, bruise.

Rabdosia rubescens：Bitter, sweet, cold nature, return lung, stomach, Liver Channel have the effect of clearing heat and detoxicating, promoting blood circulation and stopping pain, cure mainly pharynx The cards such as larynx swelling and pain, tonsillitis, cold headache, tracheitis, chronic hepatitis, articular rheumatic pain, snakebite and bugbite.

The root bark of white mulberry：Latin nameMori Cortex, it is sweet in flavor, it is cold in nature, enter lung channel, there is removing heat from lung and relieving asthma, the work(of inducing diuresis for removing edema Effect, for diseases such as lung heat cough and asthma, the edema of the face, difficult urinations.

Caulis piperis futokadsurae：Acrid flavour, hardship, slightly warm in nature, return liver warp have the effect of wind-damp dispelling, degrading the channel, stopping numbness pain, cure mainly chill The cards such as arthritis with fixed pain caused by dampness, podomere pain, muscle arteries and veins contraction, joint stuffiness.

Cattail pollen：It is sweet in flavor, it is mild-natured, enter liver, pericardium channel, have hemostasis, stagnation resolvation, it is treating stranguria the effect of.For spitting blood, bleeding from five sense organs or subcutaneous tissue is coughed up The cards such as blood, uterine bleeding, traumatic hemorrhage, closed dysmenorrhea, gastral cavity abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.

Felwort：Bitter, it is cold in nature.Return liver, gallbladder channel have the effect of heat-clearing and damp-drying drug, purging the liver of pathogenic fire is calmed the frightened, cure mainly jaundice with damp-heat pathogen； Urine leaching pain；Swelling of vulva pruritus vulvae；Under humid tropics；The alliteration headache of liver and gall excess fire；Red eye, swell pain；Deaf ear swells；Hypochondriac pain bitter taste；Pyreticosis The cards such as convulsion.

Poria cocos：It is sweet in flavor, light, it is mild-natured, enter spleen, lung, bladder, the heart channel of Hang-Shaoyin, there is eliminating dampness and diuresis, invigorating the spleen calming heart, it is main to use In the oedema of retention of water-damp, difficult urination；The heat gonorrhea of damp-heat accumulation, anorexia and loose stool, phlegm and retained fluid stagnation, the epilepsy of water retention due to hypofunction of the spleen etc. Card, Poria cocos have significant inhibiting effect to staphylococcus aureus, proteus.

Liniment provided by the invention can prepare various external application dosage forms, be preferably prepared to pad pasting.

The present invention also provides a kind of pad pasting for preventing mumps, preparation method is specially：

The complication of the mumps of the medical treatment is orchitis.

The present invention will be described in detail below with reference to the drawings of preferred embodiments, whereby to the present invention how applied technology method To solve technical problem, and the realization process for reaching technique effect can fully understand and implement according to this.

1 decoction 1 of embodiment

By cape jasmine 40g, Radix Isatidis 55g, safflower 30g, Selaginella tamariscina 25g, prepared rehmannia root 15g, Caulis Spatholobi 25g, root of Twelve stamen Melastoma 15g, white Pick up the ears 20g, Chinese yam 25g, radix scrophulariae 20g, coix seed 25g, mistletoe 20g, motherwort 25g, giant knotweed 35g and Radix Glycyrrhizae 20g is added in and is held In device, the water of 2.8kg is poured into container, after impregnating 3 hours, is boiled 4 hours, is extracted, the water of 2kg is added in again, it is small to boil 3 When, extraction finally, adds in the water of 1.6kg, and heating is boiled 2 hours, is extracted；Merge extracting solution three times, filtering obtains filtrate, depressurizes Part water is removed, obtains the decoction 1 of 1g (crude drug)/ml.

2 decoction 2 of embodiment

By cape jasmine 38g, Radix Isatidis 53g, safflower 28g, Selaginella tamariscina 23g, prepared rehmannia root 13g, Caulis Spatholobi 23g, root of Twelve stamen Melastoma 13g, white Pick up the ears 18g, Chinese yam 23g, radix scrophulariae 18g, coix seed 23g, mistletoe 18g, motherwort 23g, giant knotweed 33g and Radix Glycyrrhizae 18g is added in and is held In device, the water of 2.8kg is poured into container, after impregnating 3 hours, is boiled 4 hours, is extracted, the water of 2kg is added in again, it is small to boil 3 When, extraction finally, adds in the water of 1.6kg, and heating is boiled 2 hours, is extracted；Merge extracting solution three times, filtering obtains filtrate, depressurizes Part water is removed, obtains the decoction 2 of 1g (crude drug)/ml.

3 decoction 3 of embodiment

By cape jasmine 42g, Radix Isatidis 57g, safflower 32g, Selaginella tamariscina 27g, prepared rehmannia root 17g, Caulis Spatholobi 27g, root of Twelve stamen Melastoma 17g, white Pick up the ears 22g, Chinese yam 27g, radix scrophulariae 22g, coix seed 27g, mistletoe 22g, motherwort 27g, giant knotweed 37g and Radix Glycyrrhizae 22g is added in and is held In device, the water of 2.8kg is poured into container, after impregnating 3 hours, is boiled 4 hours, is extracted, the water of 2kg is added in again, it is small to boil 3 When, extraction finally, adds in the water of 1.6kg, and heating is boiled 2 hours, is extracted；Merge extracting solution three times, filtering obtains filtrate, depressurizes Part water is removed, obtains the decoction 3 of 1g (crude drug)/ml.

4 toxicity detection of embodiment

60 SD rats are taken, are grouped at random by weight, every group 20, half male and half female, half male and half female is divided into three groups, respectively Gavage rat embodiment 1 is to decoction 1 prepared by embodiment 3 to decoction 3, first group of gavage decoction 1, second group of gavage decoction 2, and Three groups of gavage decoctions 3, administration carry out acute toxicity test, and dosage is 6.0ml/, does not as a result occur any toxic reaction, To observation post administration 7 days, as a result all rats, which are good for, deposited, and activity, diet, hair, excreta are no abnormal, have no that toxicity is anti- It should.To post mortem at rat, main organs observation Non Apparent Abnormality.

SD rats 30 are taken, half male and half female is divided into three groups, the decoction that respectively prepared by gavage rat embodiment 1 to embodiment 3 1 is grown to decoction 3, first group of gavage decoction 1, second group of gavage decoction 2,3, the 8 month long term administrations of third group gavage decoction Phase toxicity test, the results showed that the indexs such as all rat general status, growth and development, blood routine, Liver and kidney function are showed no exception Change, Histopathology and gross necropsy also have no pathological change.

Toxicity test proves that the medicine no toxic effects and adverse reaction, clinical practice are safe and reliable.

5 paste 1 of embodiment

By cloud sedge 20g, benbie 25g, bush 20g, schizonepeta 5g, Rabdosia rubescens 15g, root bark of white mulberry 20g, caulis piperis futokadsurae 15g, Pu Yellow 40g, felwort 20g and Poria cocos 25g are added in container, the ethyl alcohol that the determining alcohol for adding 800h is 80%, after being heated to reflux 4 hours Extraction, extracting solution filtering, the determining alcohol that 600g is further added in the filter residue of acquisition is 80% ethyl alcohol, is heated to reflux 2 again It is extracted after hour, the filtered fluid obtained twice is mixed, is concentrated under reduced pressure, being concentrated into relative density is by extracting solution filtering The medicinal extract of 1.32 (70 DEG C) takes 200g medicinal extract, adds in 200g albolene, stirs evenly, be tuned into paste 1.

6 paste 2 of embodiment

By cloud sedge 18g, benbie 23g, bush 18g, schizonepeta 3g, Rabdosia rubescens 13g, root bark of white mulberry 18g, caulis piperis futokadsurae 13g, Pu Yellow 38g, felwort 18g and Poria cocos 23g are added in container, the ethyl alcohol that the determining alcohol for adding 800h is 80%, after being heated to reflux 4 hours Extraction, extracting solution filtering, the determining alcohol that 600g is further added in the filter residue of acquisition is 80% ethyl alcohol, is heated to reflux 2 again It is extracted after hour, the filtered fluid obtained twice is mixed, is concentrated under reduced pressure, being concentrated into relative density is by extracting solution filtering The medicinal extract of 1.32 (70 DEG C) takes 200g medicinal extract, adds in 200g albolene, stirs evenly, be tuned into paste 2.

7 paste 3 of embodiment

By cloud sedge 22g, benbie 27g, bush 22g, schizonepeta 7g, Rabdosia rubescens 17g, root bark of white mulberry 22g, caulis piperis futokadsurae 17g, Pu Yellow 42g, felwort 22g and Poria cocos 27g are added in container, the ethyl alcohol that the determining alcohol for adding 800h is 80%, after being heated to reflux 4 hours Extraction, extracting solution filtering, the determining alcohol that 600g is further added in the filter residue of acquisition is 80% ethyl alcohol, is heated to reflux 2 again It is extracted after hour, the filtered fluid obtained twice is mixed, is concentrated under reduced pressure, being concentrated into relative density is by extracting solution filtering The medicinal extract of 1.32 (70 DEG C) takes 200g medicinal extract, adds in 200g albolene, stirs evenly, be tuned into paste 3.

8 toxicity detection of embodiment

Skin sensitization test：

Intact skin prepares：Rabbit is taken before administration for 24 hours to shave off the hair of back backbone both sides, go gross area about 15 × 10cm²；

Damaged skin prepares：Method is identical with intact skin preparation, and depilation sterilizes afterwards for 24 hours, is drawn on the skin with syringe needle Trace to stab epidermis, does not hinder corium, and slight oozing of blood is degree.

Rabbit topical administration acute toxicity test

Rabbit is divided into blank group and experimental group, experimental group is divided into intact skin group and damaged skin group, each 2 dosage Group, every group 5, paste 1 prepared by embodiment 5 is uniformly applied to back part of animal hair removal section for 24 hours by half male and half female, for 24 hours after, Tested powder is washed away, 7d, experimental group and blank group rabbit general status, growth and development, blood routine, Liver and kidney function is observed continuously Etc. indexs be showed no abnormal change, Histopathology and gross necropsy also have no pathological change.

Result of the test shows the paste to rabbit non-toxic reaction.

Skin Irritation Test

The paste 1 to intact skin and damaged skin rabbit left dorsal hair removal section is applied, every group 3, is administered for 24 hours, Continuous 7d removes the remaining powder of family's rabbit back, and erythema and oedema situation occurs in local application position after observation is discontinued.As a result Show：Paste 1 is to rabbit without obvious irritation.

9 clinical data of embodiment

General information

2011.10 ~ 2013.6 accept mumps infant 160 for medical treatment altogether, by infant by consultation time successively using pumping Label method is divided into observation group and each 80 of control group.Man 46, female 34 in observation group；It is 5~18 years old age, 10.7 years old average.It is right According to man 43, female 37 in group；It is 6~17 years old age, 9.9 years old average.Two groups of infants compare in terms of age, gender, difference without Statistical significance（P ＞ 0.05）, it is comparable.

Diagnostic criteria

All infants meet what is issued by Ministry of Health of the People's Republic of China《Mumps diagnostic criteria》In Clinical criteria.

Inclusion criteria

1st, meet the diagnostic criteria of mumps；2nd, all infants are new hair infant, and Chinese medicine was not used and resists Viral therapy；3rd, family members' informed consent.

Therapy

Two groups of infants give and lying up, and avoid sour diet, conventional replenishing vitamins C, vitamin B₆Deng treatment, for fever Person gives Physical temperature-lowering.

Control group

It is treated using ribavirin injection, 10~15mg/ of dosage (kgd), adds in 10% Glucose Liquid medium sized vein drop Note, one time a day.

Observation group

Decoction 1 prepared by oral embodiment 1,3 times a day, each 30ml, while cream prepared by embodiment 5 is smeared in affected part Agent 1, it is daily to smear 2 times, each 1 time sooner or later, 7 days 1 courses for the treatment of.

Observation index

Infant body temperature, Parotid and submandibular gland enlargement diminution situation are observed, records fever time and pain and swelling extinction time, It checks whether with orchitis complication.

Curative effect determinate standard

It cures：Clinical symptoms completely disappear in 1 course for the treatment of, and the parotid gland, salivary gland enlargement are obviously reduced, and body temperature is down to normally； Effectively：Clinical symptoms are substantially reduced in 1 course for the treatment of, and the parotid gland, salivary gland enlargement are reduced；In vain：Various clinical symptoms in 1 course for the treatment of Do not mitigate or even aggravate, body temperature still the higher person.

Statistical method

Using SPSS13.0 statistical softwares, enumeration data uses chi-square criterion, measurement data with± s is represented, is examined using t It tests, it is statistically significant for difference with P ＜ 0.05.

As a result

Two groups of curative effects compare, and the results are shown in Table 1.

1 two groups of curative effect comparative examples (%) of table

Table 1 as can be seen that the effect of observation group to be significantly higher than control group, significant difference, P ＜ 0.05.

Two groups of patient's fever times, pain and swelling extinction time compare, and the results are shown in Table 2.

2 two groups of patient's fever times of table, pain and swelling extinction time compare (d)

Table 2 as can be seen that can be brought down a fever using drug provided by the invention and be eliminated swelling, compared with the control group faster Significant difference, P ＜ 0.05.

The number of cases of orchitis occurs for patient, the results are shown in Table 3.

The number of cases of orchitis occurs for 3 two groups of infants of table

Group	Number of cases	Orchitis number	Incidence
				Observation group	80	0	0%
Control group	80	23	28.8%

From table 3 it can be seen that orchitis number does not occur for observation group, control group has 23 human hairs to give birth to orchitis complication.

All above-mentioned this intellectual properties of primarily implementation, there is no this new products of implementation of setting limitation other forms And/or new method.Those skilled in the art will utilize this important information, the above modification, to realize similar execution feelings Condition.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above described is only a preferred embodiment of the present invention, being not that the invention has other forms of limitations, appoint What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc. Imitate embodiment.But it is every without departing from technical solution of the present invention content, technical spirit according to the present invention is to above example institute Any simple modification, equivalent variations and the remodeling made still fall within the protection domain of technical solution of the present invention.

Claims

1. a kind of endo-medicine for being used to prevent mumps, it is characterised in that：Bulk pharmaceutical chemicals by cape jasmine, Radix Isatidis, safflower, Selaginella tamariscina, prepared rehmannia root, Caulis Spatholobi, root of Twelve stamen Melastoma, foliosous parnassia herb, Chinese yam, radix scrophulariae, coix seed, mistletoe, motherwort, giant knotweed and Radix Glycyrrhizae group Weight into, each bulk pharmaceutical chemicals of endo-medicine be respectively cape jasmine 35g~45g, Radix Isatidis 50g~60g, safflower 25g~35g, Selaginella tamariscina 25g~35g, prepared rehmannia root 10g~20g, Caulis Spatholobi 20g~30g, root of Twelve stamen Melastoma 10g~20g, foliosous parnassia herb 15g~25g, Chinese yam 20g~30g, radix scrophulariae 15g~25g, coix seed 20g~30g, mistletoe 15g~25g, motherwort 20g~30g, giant knotweed 30g~ 40g and Radix Glycyrrhizae 15g~25g.

2. endo-medicine as described in claim 1, it is characterised in that：The endo-medicine is prepared into decoction.

3. the preparation method of any endo-medicine in claim 1 to 2, it is characterised in that：Above-mentioned raw materials medicine is added in In container, the water relative to each 6~8 times of amounts of bulk pharmaceutical chemicals quality sum is poured into container, after impregnating 2~3 hours, boils 3~4 Hour, extraction adds in again relative to each 4~6 times of amount water of bulk pharmaceutical chemicals quality sum, boils 2~3 hours, extract, finally, add Enter relative to each 3~5 times of amount water of bulk pharmaceutical chemicals quality sum, heating is boiled 1~2 hour, extracted；Merge extracting solution three times, filter, Filtrate is obtained, part water is removed under reduced pressure, obtains the decoction of the 1g/ml containing crude drug amount.

4. a kind of liniment for being used to prevent mumps, it is characterised in that：Bulk pharmaceutical chemicals are by cloud sedge, benbie, Soviet Union Wood, schizonepeta, Rabdosia rubescens, the root bark of white mulberry, caulis piperis futokadsurae, cattail pollen, felwort and Poria cocos composition；The weight of each bulk pharmaceutical chemicals in the liniment Amount respectively cloud sedge 15g~25g, benbie 20g~30g, bush 15g~25g, schizonepeta 1g~10g, Rabdosia rubescens 10g~ 20g, root bark of white mulberry 15g~25g, caulis piperis futokadsurae 10g~20g, cattail pollen 35g~45g, felwort 15g~25g and Poria cocos 20g~30g.

5. liniment as claimed in claim 4, it is characterised in that：The weight of each bulk pharmaceutical chemicals is respectively in the liniment Cloud sedge 18g~22g, benbie 23g~27g, bush 18g~22g, schizonepeta 3g~7g, Rabdosia rubescens 13g~17g, the root bark of white mulberry 18g~22g, caulis piperis futokadsurae 13g~17g, cattail pollen 38g~42g, felwort 18g~22g and Poria cocos 23g~27g.

6. the liniment as described in claim 4-5 is any, it is characterised in that：The liniment is prepared into pad pasting.

7. the preparation method of liniment as described in claim 4-5 is any, which is characterized in that including：The first step, Jiang Geyuan Expect that medicine is added in container, add the ethyl alcohol that the determining alcohol relative to each 3~5 times of bulk pharmaceutical chemicals quality sum is 70%~80%, heating Reflux is extracted after 2~4 hours, and extracting solution filtering is further added in the filter residue of acquisition relative to each bulk pharmaceutical chemicals quality sum 2 ~4 times of determining alcohol is 70%~80% ethyl alcohol, is extracted after being heated to reflux 1~2 hour again, extracting solution filtering, will twice The filtered fluid mixing of acquisition, is concentrated under reduced pressure, and is concentrated into the medicinal extract that relative density at 70 DEG C is 1.29~1.32；Second step, In the medicinal extract prepared in the first step, albolene is added in, stirs evenly, is tuned into the mass ratio of paste, medicinal extract and albolene It is 1：1.