CN105381307A - Traditional Chinese medicine composition for treating mastitis and preparing method thereof - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating mastitis and a preparing method thereof. The traditional Chinese medicine composition is prepared from all-grass of broadleaf ainslaea, radix angelicae sinensis, medlar, Inula cappa, honeysuckle, dandelions, leonurus, cyperus rotundus, platycodon grandiflorum, rhizoma atractylodis macrocephalae, pig trotters, trichosanthes kirilowii maxim, radix astragali, field sowthistle herb, hedyotis diffusa, radix bupleuri, cowherb seeds, andrographis paniculata, salvia miltiorrhiza, wild chrysanthemums and the like. The traditional Chinese medicine preparation is prepared by adopting the modern advanced medicine pharmaceutical technology, conforms to theories of traditional Chinese medicine and modern medicine, has the effects of regulating the flow of vital energy, removing stasis, promoting lactation, dredging collaterals, clearing heat, diminishing swelling and the like, is capable of adjusting internal secretion, nourishing qi and blood and improving microcirculation of the human body, and has a remarkable effect on mastitis treatment. Compared with medicine of the same kind, the traditional Chinese medicine composition has the advantages of being precise in compatibility, mild in medicine property and remarkable in effect and can be clinically applied and popularized on a large scale conveniently.

Description

A kind of Chinese medicine composition for the treatment of mastitis and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to a kind of Chinese medicine composition for the treatment of mastitis and preparation method thereof.

Background technology

Mastitis are the common diseases of women, can be divided into acute purulent mammitis, mammary areola other fistula, plasma cell mastitis etc., state at this with modal acute purulent mammitis according to the difference of the cause of disease.Acute purulent mammitis often betides age of sucking, particularly in 1 ~ 2 month puerperal of primipara, therefore cry again acute age of sucking or puerperal suppurative mastitis, the traditional Chinese medical science is called " acute mastitis ".The sickness rate of primipara's acute mastitis up to 2% ~ 4%, more than multipara's mastitis 1 times.Human milk silt occurs together bacteriological infection and falling ill, and shows, red and swollen heat pain, the high heat of shiver with cold in acute inflammation, in early days can maneuver milk ejection, and treatment by Chinese herbs, then needs incision and drainage after suppurating.After morbidity, not only puerpera is painful abnormal, and can not continue suckling, affects the health of baby, so will prevent from latter half of gestation, carry out health care in puerperal, acute mastitis can be prevented.

Serious disease mastitis patient can with hyperpyrexia, shiver with cold, and breast swell and pain is obvious, and local skin is red and swollen, has scleroma, tenderness, the enlargement of Ipsilateral axillary lymph knot.Inflammation is softening within a couple of days, forms galactapostema, has fluctuation, the skin rubefaction that abscess is dark and fluctuation not obvious.After ulceration comes to a head, pus drain is unobstructed, can swell disappear alleviation of pain and more acute mastitis often with the enlargement of Ipsilateral axillary gland, have tenderness; Total white blood cells and neutrophilic granulocyte number increase.After suffering from mastitis, if the hazardness of malpractice mastitis is just larger, abscess just likely wears out loose connective tissue before pectoralis major fascia, form retromammary abscess, or milk overflows from wound place and forms mammary fistula, notably pyaemia septica can occur.

At present, mastitis adopt western medicine antibiotics therapy and operative treatment to be main usually, life-time service patient easily produces drug resistance and side effect is comparatively large, although all have certain curative effect, therapeutic effect is not thorough, also easily recurrence after curing, and therapeutic domain is narrow, medicine time is long, and relative cost costly, Chinese medicine has the curative effect of its uniqueness in treatment mastitis, but the clinical Chinese medicine lacking the treatment mastitis of determined curative effect.

Summary of the invention

In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine composition for the treatment of mastitis, to mastitis, there is significant curative effect.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition for the treatment of mastitis, be made up of following component: Herba Ainsliaeae Latifoliae, Radix Angelicae Sinensis, Fructus Lycii, Herba Inulae cappae, Flos Lonicerae, Herba Taraxaci, Herba Leonuri, Rhizoma Cyperi, Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae, Ungula Sus domestica, Fructus Trichosanthis, the Radix Astragali, Sonchus arvensis L., Hedyotidis Diffusae, Radix Bupleuri, Semen Vaccariae, Herba Andrographis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi Indici, the Radix Paeoniae Alba, Pheretima, Olibanum, Poria, Fructus Akebiae, Herba Patriniae, Stigma Maydis, Fructus Forsythiae, Radix Scorzonerae austriacae, Herba monochasmatis, Concha Ostreae, Dioscorea zingiberensis, Ramulus Cinnamomi, Cornu Cervi Degelatinatum, Fructus Liquidambaris, Bulbus Fritillariae Uninbracteatae, Rhizoma Gymnadeniae, Spica Prunellae, Flos Genkwa.

The Chinese medicine composition of described treatment mastitis, in Chinese medicine preparation described in it, the parts by weight of various crude drug can be preferably:

Herba Ainsliaeae Latifoliae 1-30 part, Radix Angelicae Sinensis 1-30 part, Fructus Lycii 1-30 part, Herba Inulae cappae 1-30 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-30 part, Herba Leonuri 1-30 part, Rhizoma Cyperi 1-30 part, Radix Platycodonis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Ungula Sus domestica 1-30 part, Fructus Trichosanthis 1-30 part, Radix Astragali 1-30 part, Sonchus arvensis L. 1-30 part, Hedyotidis Diffusae 1-30 part, Radix Bupleuri 1-30 part, Semen Vaccariae 1-30 part, Herba Andrographis 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Flos Chrysanthemi Indici 1-30 part, Radix Paeoniae Alba 1-30 part, Pheretima 1-30 part, Olibanum 1-30 part, Poria 1-30 part, Fructus Akebiae 1-30 part, Herba Patriniae 1-30 part, Stigma Maydis 1-30 part, Fructus Forsythiae 1-30 part, Radix Scorzonerae austriacae 1-30 part, Herba monochasmatis 1-30 part, Concha Ostreae 1-30 part, Dioscorea zingiberensis 1-30 part, Ramulus Cinnamomi 1-30 part, Cornu Cervi Degelatinatum 1-30 part, Fructus Liquidambaris 1-30 part, Bulbus Fritillariae Uninbracteatae 1-30 part, Rhizoma Gymnadeniae 1-30 part, Spica Prunellae 1-30 part, Flos Genkwa 1-30 part.

The Chinese medicine composition of described treatment mastitis, in Chinese medicine preparation described in it, the parts by weight of various crude drug can also be preferably:

Herba Ainsliaeae Latifoliae 1-15 part, Radix Angelicae Sinensis 1-20 part, Fructus Lycii 1-20 part, Herba Inulae cappae 1-10 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-20 part, Herba Leonuri 1-30 part, Rhizoma Cyperi 1-10 part, Radix Platycodonis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-15 part, Ungula Sus domestica 1-15 part, Fructus Trichosanthis 1-30 part, Radix Astragali 1-30 part, Sonchus arvensis L. 1-30 part, Hedyotidis Diffusae 1-30 part, Radix Bupleuri 1-30 part, Semen Vaccariae 1-15 part, Herba Andrographis 1-15 part, Radix Salviae Miltiorrhizae 1-30 part, Flos Chrysanthemi Indici 1-30 part, Radix Paeoniae Alba 1-30 part, Pheretima 1-15 part, Olibanum 1-30 part, Poria 1-15 part, Fructus Akebiae 1-15 part, Herba Patriniae 1-30 part, Stigma Maydis 1-30 part, Fructus Forsythiae 1-30 part, Radix Scorzonerae austriacae 1-15 part, Herba monochasmatis 1-15 part, Concha Ostreae 1-15 part, Dioscorea zingiberensis 1-30 part, Ramulus Cinnamomi 1-15 part, Cornu Cervi Degelatinatum 1-15 part, Fructus Liquidambaris 1-15 part, Bulbus Fritillariae Uninbracteatae 1-30 part, Rhizoma Gymnadeniae 1-15 part, Spica Prunellae 1-30 part, Flos Genkwa 1-30 part.

The Chinese medicine composition of described treatment mastitis, in Chinese medicine preparation described in it, the parts by weight of various crude drug can also be preferably:

Herba Ainsliaeae Latifoliae 1-10 part, Radix Angelicae Sinensis 1-10 part, Fructus Lycii 1-10 part, Herba Inulae cappae 1-5 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-5 part, Herba Leonuri 1-5 part, Rhizoma Cyperi 1-10 part, Radix Platycodonis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-10 part, Ungula Sus domestica 1-15 part, Fructus Trichosanthis 1-10 part, Radix Astragali 1-10 part, Sonchus arvensis L. 1-10 part, Hedyotidis Diffusae 1-10 part, Radix Bupleuri 1-10 part, Semen Vaccariae 1-15 part, Herba Andrographis 1-15 part, Radix Salviae Miltiorrhizae 1-10 part, Flos Chrysanthemi Indici 1-30 part, Radix Paeoniae Alba 1-30 part, Pheretima 1-15 part, Olibanum 1-30 part, Poria 1-15 part, Fructus Akebiae 1-15 part, Herba Patriniae 1-10 part, Stigma Maydis 1-30 part, Fructus Forsythiae 1-30 part, Radix Scorzonerae austriacae 1-15 part, Herba monochasmatis 1-10 part, Concha Ostreae 1-15 part, Dioscorea zingiberensis 1-30 part, Ramulus Cinnamomi 1-15 part, Cornu Cervi Degelatinatum 1-15 part, Fructus Liquidambaris 1-5 part, Bulbus Fritillariae Uninbracteatae 1-10 part, Rhizoma Gymnadeniae 1-10 part, Spica Prunellae 1-10 part, Flos Genkwa 1-10 part.

The Chinese medicine composition of described treatment mastitis, the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine composition for the treatment of mastitis, and when the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps::

A, adopt alcohol extracting method through filtering Herba Ainsliaeae Latifoliae, Radix Angelicae Sinensis, Fructus Lycii, Herba Inulae cappae, Flos Lonicerae, Herba Taraxaci, Herba Leonuri, Rhizoma Cyperi, Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae, concentrated, dry, pulverize, powder;

B, by Ungula Sus domestica, Fructus Trichosanthis, the Radix Astragali, Sonchus arvensis L., Hedyotidis Diffusae, Radix Bupleuri, Semen Vaccariae, Herba Andrographis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi Indici, the Radix Paeoniae Alba, Pheretima, Olibanum, Poria, Fructus Akebiae adopt supercritical extraction, obtain supercritical extract, for subsequent use;

C, all the other crude drug decoct with water 2 times, after Aqueous extracts filters, and one-tenth extractum to be concentrated; Extractum Direct spraying is dried to spraying powder;

D, the canned capsule of medicated powder that above-mentioned steps is collected.

In a of described step, described crude drug is put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use.

In described step b, described crude drug is joined CO ₂in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 25MPa, temperature 60 C, CO ₂flow 3ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use.

To in described step c, get the water soaking 1-2 hour that crude drug adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, filter, be concentrated into extractum shape, extractum Direct spraying is dried to spraying powder.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine composition for the treatment of mastitis, and the dosage form of described Chinese medicine preparation is oral solutions, and its preparation process comprises:

A, get crude drug and put into water and soak, heat is extracted 2 times, and becoming extractum shape, is component 1;

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.

The present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.Chinese medicine preparation of the present invention adopts modern advanced medical pharmaceutical technology to make, and meets Chinese medicine and modern medicine theory, has eliminating stagnation of regulating the flow of vital energy, declares newborn dredging collateral, expel the heat-evil the effects such as detumescence, can endocrine regulation, nourishing qi and blood, improves microcirculation in human body, and the treatment for mastitis has significant curative effect.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.

Detailed description of the invention

No matter be Cesarean esction or natural labor, women divides puerperium passive protective physical fitness can obviously decline, and is easy to infect various diseases, and meanwhile, mastitis also have much relations with mammary gland local factor.Hypomastia or cave in, polygalactia or baby suck hypogalactia and not timely milk to be emptied completely, suckling fault, lactiferous ducts are obstructed etc., and factor all can cause human milk silt, for bacterial reproduction growth holds out a fair chance.In addition, breast occurs damaged or when chapping, the antibacterial also easy lactiferous ducts that causes via lymphatic vessel infects.

Herba Ainsliaeae Latifoliae: nature and flavor: acrid in the mouth; Micro-hardship; Warm in nature.Function cures mainly: expelling wind and cold; Promoting blood circulation and detumescence.Main anemofrigid cold; Headache; Lumbago; Intestinal fire; Dysentery; Traumatic injury congestive edema; Traumatic hemorrhage; Otitis media; Mastitis.

Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.

Herba Inulae cappae: nature and flavor: 1. " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth is micro-pungent, and temper is nontoxic." 2. " Hunan medicine will ": " is pungent, temperature, nontoxic." return through: " Quanzhou book on Chinese herbal medicine ": " enters liver, lung, spleen, all warps of stomach." function cures mainly: dispel the wind, dampness removing, circulation of qi promoting, changes stagnant.Dispelling the wind and dampness pathogens arthralgia, chest and diaphragm painful abdominal mass is vexed, malaria, and dysentery is had loose bowels, and puerperal catches a cold, hepatitis, hemorrhoid, scabies.

Flos Lonicerae: nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.

Herba Taraxaci: nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Herba Leonuri: nature and flavor: arduous, cool.1. supplement to the Herbal: " cold." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid-sweet flavor, feeble QI temperature, nontoxic." 3. " detailed outline ": " micro-hardship of acrid in the mouth, nontoxic." 4. " book on Chinese herbal medicine just ": " mildly bitter flavor, micro-pungent.Be slightly cold, property is sliding." return through: enter pericardium, Liver Channel.1. " book on Chinese herbal medicine converges and says ": " hands, meridian of Foot-JUE YIN." 2. " medicineization justice ": " enters liver, spleen, envelope three warp." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warp." function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Rhizoma Cyperi: nature and flavor: pungent, micro-hardship, micro-sweet, flat.Gui Jing: return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Radix Platycodonis: nature and flavor: toil is flat.1. " herbal classic ": " pungent, tepor." 2. " not Lu ": " be bitter, slightly poisonous." 3. " property of medicine opinion ": " is bitter, flat, nontoxic.Gui Jing: enter lung, stomach warp.1. Materia Medica of Decoction: " enter the few the moon of foot, hands is lunar." 2. " product remittance essence is wanted ": " row meridian of Foot-TAI YIN." 3. " Bencao Jingshu ": " starts with lunar, few cloudy, double enter the stomach channel of foot-Yang-ming." function cures mainly: open lung qi dispersing gas, evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain.

The Rhizoma Atractylodis Macrocephalae: nature and flavor: pungent, micro-hardship, micro-sweet is flat.Gui Jing: return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Ungula Sus domestica: nature and flavor: Gan Xian is flat.1. " daily book on Chinese herbal medicine ": " sweet in the mouth is micro-cool." 2. " detailed outline ": " is sweet salty, the Slight Cold, nontoxic." return through: " book on Chinese herbal medicine is just read ": " enters stomach warp." function cures mainly: enrich blood, lactogenesis, holder skin ulcer.Control married woman's breast few, carbuncle, sore.1. " not Lu ": " main wound is flogged and allly lost skin ulcer, lower milk." 2. " Bencao Tujing ": " row married woman breast arteries and veins, sliding skin, cold removing heat." 3. " detailed outline ": " boils clear juice, washes carbuncle, stain pyretic toxicity, sterilization gas, goes to dislike meat." 4. " occupying diet spectrum with breath ": " fills out kidney essense and is good for waist foot, and grow gastric juice to slide skin, longue meat more can leak infections, helps blood vessels can fill milk, and comparatively meat is mended especially."

Fructus Trichosanthis: nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Sonchus arvensis L.: nature and flavor: bitter, cold.1. " Traditional Chinese Medicine in Sichuan will ": " cold in nature, bitter and puckery flavor is nontoxic." 2. " Guangxi Chinese herbal medicine ": " is bitter, cold, nontoxic." function cures mainly: heat-clearing and toxic substances removing.Appendicitis curing, dysentery, hemorrhoid, seminal emission, nebulousurine, mastitis, furuncle kind poison, burn.1. " conventional glossary of Herbs and Drugs among the people ": " control nebulousurine, seminal emission, hemorrhoid." 2. " Traditional Chinese Medicine in Sichuan will ": " removing toxic substances heat extraction.Control burn and unknown kind poison." 3. Guangzhou air force " conventional Chinese herbal medicine handbook ": " appendicitis curing, dysentery, mastitis, furuncle and phyma."

Hedyotidis Diffusae: nature and flavor: sweet, light, cool.Gui Jing: enter stomach, large intestine, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.

Radix Bupleuri: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Semen Vaccariae: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Herba Andrographis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, lung, large intestine, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood, detumescence.For cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom.

Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Flos Chrysanthemi Indici: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, heart channel.Function cures mainly: heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, has a headache dizzy.

The Radix Paeoniae Alba: nature and flavor: bitter, sour, is slightly cold.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.

Pheretima: nature and flavor: salty, cold.Gui Jing: return liver, spleen, urinary bladder channel.Function cures mainly: heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.

Olibanum: nature and flavor: arduous, temperature.1. " not Lu ": " tepor." 2. " Japan hanako materia medica ": " acrid in the mouth, heat, micro-poison." 3. Li Gao: " bitter in the mouth is pungent, heat." return through: enter the heart, liver, spleen channel.1. Zhu Zhenheng: " enter meridian of Hand-SHAO YIN.It is few cloudy that " 2. " Bencao Jingshu ": " enters lunar, the hands of foot, double enter meridian of Foot-JUE YIN." function cures mainly: regulating qi and activating blood, and analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.

Poria: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Fructus Akebiae: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Herba Patriniae: nature and flavor: pungent, bitter, cool.Gui Jing: enter stomach, large intestine, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Stigma Maydis: nature and flavor: sweet, light is flat.Gui Jing: return bladder, liver, gallbladder meridian.Function cures mainly: inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice.And can habitual abortion be prevented.

Fructus Forsythiae: nature and flavor: bitter, is slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.

Radix Scorzonerae austriacae: nature and flavor: micro-bitterness; Cold.Gui Jing: heart channel.Function cures mainly: subduing swelling and detoxicating.Main infirmities and diseases; Furuncle carbuncle.

Herba monochasmatis: nature and flavor: bitter in the mouth; Puckery; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Wind-expelling pain-stopping; Cooling blood for hemostasis.Main flu; Cough; Pneumonia is generated heat; Infantile thrush; Toothache; Rheumatic ostalgia; Furuncle carbuncle; Menoxenia; Metrorrhagia; Leucorrhea with red and white discharge; Have blood in stool; Leaf blood; Traumatic hemorrhage.

Concha Ostreae: nature and flavor: salty, is slightly cold.Gui Jing: return liver, gallbladder, kidney channel.Function cures mainly: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Dioscorea zingiberensis: nature and flavor: pungent, bitter, temperature.Gui Jing: return spleen, Liver Channel.Function cures mainly: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.

Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Function cures mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Cornu Cervi Degelatinatum: nature and flavor: salty in the mouth, puckery, warm in nature.Gui Jing: kidney; Liver Channel.Function cures mainly: reinforcing the kidney and supporting YANG; Astringing to arrest bleeding.Main insufficiency of kidney-YANG; Deficiency and coldness of spleen and stomach; Anorexia and loose stool; Impotence and seminal emission; Frequent urination and enuresis; Metrorrhagia; Leukorrhagia; Wound hemorrhage; Skin infection disunion of a specified duration.

Fructus Liquidambaris: nature and flavor: bitter is flat.1. " modern Practical Chinese medicinal ": " bitter and puckery flavor, property is put down, nontoxic." 2. " Zhejiang traditional herbal medicine ": " property is put down, lightly seasoned, nontoxic." 3. " Quanzhou book on Chinese herbal medicine ": " is arduous, and property is put down, nontoxic." return through: " detailed outline is picked up any lost article from the road ": " current 12 warps." function cures mainly: dispelling wind and removing obstruction in the collateral, and diuretic dehumidifies.Control limbs arthralgia pain, contracture of the limbs, stomachache, edema, distension, amenorrhea, breast is few, carbuncle, anal fistula, scabies, eczema.

Bulbus Fritillariae Uninbracteatae: nature and flavor: bitter, sweet, is slightly cold.Gui Jing: return lung, heart channel.Function cures mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.

Rhizoma Gymnadeniae: nature and flavor: sweet; Flat.Gui Jing: lung; Spleen; Stomach warp.Function cures mainly: relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.

Spica Prunellae: nature and flavor: pungent, bitter, cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.

Flos Genkwa: nature and flavor: flower: bitter, acrid, cold; Poisonous.Root bark: pungent, bitter is flat.Poisonous.Gui Jing: return lung, spleen, kidney channel.Function cures mainly: flower: removing fluid-retention by purgation, removing toxic substances parasite killing.For edema distension, breast abdomen hydrops, phlegm retention is gathered, and QI rising in reverse order is breathed with cough, difficulty in urination and defecation; External treatment scabies tinea alba, chilblain.

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

A, Herba Ainsliaeae Latifoliae 10 parts, Radix Angelicae Sinensis 3 parts, Fructus Lycii 5 parts, Herba Inulae cappae 3 parts, Flos Lonicerae 7 parts, Herba Taraxaci 5 parts, Herba Leonuri 5 parts, Rhizoma Cyperi 4 parts, Radix Platycodonis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts of crude drug are put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use.

B, 5 parts, Ungula Sus domestica, Fructus Trichosanthis 3 parts, the Radix Astragali 4 parts, Sonchus arvensis L. 4 parts, Hedyotidis Diffusae 3 parts, Radix Bupleuri 4 parts, Semen Vaccariae 5 parts, Herba Andrographis 7 parts, Radix Salviae Miltiorrhizae 5 parts, Flos Chrysanthemi Indici 6 parts, the Radix Paeoniae Alba 7 parts, Pheretima 8 parts, Olibanum 7 parts, 6 parts, Poria, Fructus Akebiae 4 parts of crude drug are joined CO ₂in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 25MPa, temperature 60 C, CO ₂flow 3ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use.

C, get Herba Patriniae 3 parts, water soaking 1-2 hour that Stigma Maydis 7 parts, Fructus Forsythiae 4 parts, Radix Scorzonerae austriacae 3 parts, Herba monochasmatis 3 parts, Concha Ostreae 4 parts, Dioscorea zingiberensis 5 parts, Ramulus Cinnamomi 5 parts, Cornu Cervi Degelatinatum 3 parts, Fructus Liquidambaris 3 parts, Bulbus Fritillariae Uninbracteatae 3 parts, Rhizoma Gymnadeniae 4 parts, Spica Prunellae 7 parts, Flos Genkwa 3 parts of crude drug add 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, filter, be concentrated into extractum shape, extractum Direct spraying is dried to spraying powder.

D, the canned capsule of medicated powder that above-mentioned steps is collected.

Embodiment 2

A, Herba Ainsliaeae Latifoliae 3 parts, Radix Angelicae Sinensis 1 part, Fructus Lycii 4 parts, Herba Inulae cappae 2 parts, Flos Lonicerae 5 parts, Herba Taraxaci 5 parts, Herba Leonuri 5 parts, Rhizoma Cyperi 4 parts, Radix Platycodonis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts of crude drug are put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use.

B, 2 parts, Ungula Sus domestica, Fructus Trichosanthis 2 parts, the Radix Astragali 5 parts, Sonchus arvensis L. 1 part, Hedyotidis Diffusae 2 parts, Radix Bupleuri 3 parts, Semen Vaccariae 4 parts, Herba Andrographis 2 parts, Radix Salviae Miltiorrhizae 4 parts, Flos Chrysanthemi Indici 3 parts, the Radix Paeoniae Alba 7 parts, Pheretima 4 parts, Olibanum 4 parts, 5 parts, Poria, Fructus Akebiae 4 parts of crude drug are joined CO ₂in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 25MPa, temperature 60 C, CO ₂flow 3ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use.

C, get Herba Patriniae 4 parts, water soaking 1-2 hour that Stigma Maydis 6 parts, Fructus Forsythiae 4 parts, Radix Scorzonerae austriacae 2 parts, Herba monochasmatis 1 part, Concha Ostreae 4 parts, Dioscorea zingiberensis 4 parts, Ramulus Cinnamomi 4 parts, Cornu Cervi Degelatinatum 2 parts, Fructus Liquidambaris 4 parts, Bulbus Fritillariae Uninbracteatae 3 parts, Rhizoma Gymnadeniae 4 parts, Spica Prunellae 4 parts, Flos Genkwa 3 parts of crude drug add 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, filter, be concentrated into extractum shape, extractum Direct spraying is dried to spraying powder.

D, the canned capsule of medicated powder that above-mentioned steps is collected.

Embodiment 3

A, get Herba Ainsliaeae Latifoliae 3 parts, Radix Angelicae Sinensis 1 part, Fructus Lycii 4 parts, Herba Inulae cappae 2 parts, Flos Lonicerae 5 parts, Herba Taraxaci 5 parts, Herba Leonuri 5 parts, Rhizoma Cyperi 4 parts, Radix Platycodonis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, 2 parts, Ungula Sus domestica, Fructus Trichosanthis 2 parts, the Radix Astragali 5 parts, Sonchus arvensis L. 1 part, Hedyotidis Diffusae 2 parts, Radix Bupleuri 3 parts, Semen Vaccariae 4 parts, Herba Andrographis 2 parts, Radix Salviae Miltiorrhizae 4 parts, Flos Chrysanthemi Indici 3 parts, the Radix Paeoniae Alba 7 parts, Pheretima 4 parts, Olibanum 4 parts, 5 parts, Poria, Fructus Akebiae 4 parts, Herba Patriniae 4 parts, Stigma Maydis 6 parts, Fructus Forsythiae 4 parts, Radix Scorzonerae austriacae 2 parts, Herba monochasmatis 1 part, Concha Ostreae 4 parts, Dioscorea zingiberensis 4 parts, Ramulus Cinnamomi 4 parts, Cornu Cervi Degelatinatum 2 parts, Fructus Liquidambaris 4 parts, Bulbus Fritillariae Uninbracteatae 3 parts, Rhizoma Gymnadeniae 4 parts, Spica Prunellae 4 parts, Flos Genkwa 3 parts of crude drug are put into water and are soaked, heat is extracted 2 times, become extractum shape, for component 1,

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.

The animal acute toxicity test of pharmaceutical composition of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-30g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the capsule prepared by the embodiment of the present invention 1, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.5ml, is equivalent to crude drug in whole 4.0g to each 0.5ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 14 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the capsule prepared by the embodiment of the present invention 2.

(2) laboratory animal, healthy rat Wistar, body weight 100-150g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 14 days is observed in remaining 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, Skin Irritation Test: above-mentioned three groups of medication rat trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.

Four, cumulative toxicity experiment:

Traditional Chinese medicine preparation capsule agent of the present invention presses 7.69,19.18 and 43.21g crude drug/kg continuous use 14 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 14 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical trial

Experiment material:

Select come institute go to a doctor mastitis patient 200 example, be women breast-feeding their children, 22 ~ 38 years old age, primipara 79 example, multipara 121 example; The course of disease 2 ~ 7d, clinical manifestation distending pain of the breast, heating, local skin is red and swollen, the block tuberosity lump of streak, sheet, touches a tender spot obviously, and nipple is inaccessible or flow out yellow and purulent secretion, or with ipsilateral axillary lymphadenectasis.Be divided into matched group and each 100 examples for the treatment of group at random.Two groups of patient ages, final recognition, the course of disease, clinical manifestations etc. are no difference of science of statistics all.

Diagnostic criteria

Diagnostic criteria: the diagnostic criteria with reference to acute mastitis in " practical obstetrics and gynecology ": (1) patient is women breast-feeding their children is many with the primipara of non-full moon especially; (2) from the beginning of there being painful lump in breast, companion's milk ejection is not smooth, and when abscess is formed, breast swell and pain increases the weight of, and lump deliquescing, has fluctuation; (3) patient oxter often has lymphadenectasis to accompany pain; (4) whole body has aversion to cold more, heating, headache, and the whole body is uncomfortable, and numeration of leukocyte increases.

Therapeutic Method:

Treatment group: give the embodiment of the present invention 1 capsule, every day 3 times, each 17 days is a course for the treatment of;

Matched group: intravenous infusion of penicillin is treated, and 3 times/d, breast milk humalactor in breast local swelling hot compress, and is inhaled sky by 25% magnesium sulfate completely, treats 7 days.

Efficacy determination:

(1) fully recover: mammary swelling, pain, lump tenderness, surface is red and swollen, and the symptoms such as heating disappear entirely.

(2) take a turn for the better: hyperpyrexia is moved back, galactapostema is softened, and side axillary gland diminishes.

(3) invalid: symptom is with treating front no significant difference.。

Therapeutic outcome:

Two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1 and Table 2, adopt treatment by Chinese herbs acute mastitis of the present invention, relative to Western medicine on therapeutic effect, there is significant advantage.

Table 1 liang group treatment clinical efficacy

Group	N	Cure	Effectively	Invalid	Effectively total
						Treatment group	100	81	18	1	99.0％
Matched group	100	49	17	24	76.0％

Table 2 the present invention is curing the impact between number and treatment

Group	N	3d	5d	7d
					Treatment group	99	36(36.4％)	45(45.4％)	18(18.2％)
Matched group	76	0(0％)	38(50％)	38(50％)

Untoward reaction

Over the course for the treatment of tracing observation is carried out for 100 routine patients, does not find obvious untoward reaction.

Case 1: Hu, female, 41 years old, left distending pain of the breast 6 days, local skin was rubescent, touches enclosed mass, tenderness, and Pi Wen is slightly high.Mastitis on the left of Found by Mammography binding of pathological puncture diagnosis, use Drug therapy of the present invention after 3 days symptom substantially disappear, cure after 7 days.

Case 2: the Qin so-and-so, female, 28 years old.Latter two moon is produced in primiparity, and lochia is clean.Right mammary swelling, bitterly, milk drainage difficulty 4 days, and with symptom such as heating (body temperature 38.6 DEG C), headache etc., find through checking, obviously, border owes clear to the outside upper quadrant caking of right breast, tenderness, Pi Wenlvegao, color of the leather is micro-red, is acute mastitis, after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, the state of an illness is fully recovered, and has no recurrence.

Case 3: Zhang, female, 34 years old, right side breast distending pain 3 days, Found by Mammography was shown in right newborn LIQ lumps high density shadow, and blur margin is clear, and local skin, without thickening, has no calcification in it.Pathology puncture diagnosis right side breast is scorching.Take medicine of the present invention after 3 days symptom alleviate, substantially cure after 2 courses for the treatment of.

The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims (10)

1. treat a Chinese medicine composition for mastitis, it is characterized in that: be made up of following component:

Herba Ainsliaeae Latifoliae, Radix Angelicae Sinensis, Fructus Lycii, Herba Inulae cappae, Flos Lonicerae, Herba Taraxaci, Herba Leonuri, Rhizoma Cyperi, Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae, Ungula Sus domestica, Fructus Trichosanthis, the Radix Astragali, Sonchus arvensis L., Hedyotidis Diffusae, Radix Bupleuri, Semen Vaccariae, Herba Andrographis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi Indici, the Radix Paeoniae Alba, Pheretima, Olibanum, Poria, Fructus Akebiae, Herba Patriniae, Stigma Maydis, Fructus Forsythiae, Radix Scorzonerae austriacae, Herba monochasmatis, Concha Ostreae, Dioscorea zingiberensis, Ramulus Cinnamomi, Cornu Cervi Degelatinatum, Fructus Liquidambaris, Bulbus Fritillariae Uninbracteatae, Rhizoma Gymnadeniae, Spica Prunellae, Flos Genkwa.

2. a kind of Chinese medicine composition for the treatment of mastitis according to claim 1, is characterized in that: be made up of each component of following parts by weight:

Herba Ainsliaeae Latifoliae 1-30 part, Radix Angelicae Sinensis 1-30 part, Fructus Lycii 1-30 part, Herba Inulae cappae 1-30 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-30 part, Herba Leonuri 1-30 part, Rhizoma Cyperi 1-30 part, Radix Platycodonis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Ungula Sus domestica 1-30 part, Fructus Trichosanthis 1-30 part, Radix Astragali 1-30 part, Sonchus arvensis L. 1-30 part, Hedyotidis Diffusae 1-30 part, Radix Bupleuri 1-30 part, Semen Vaccariae 1-30 part, Herba Andrographis 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Flos Chrysanthemi Indici 1-30 part, Radix Paeoniae Alba 1-30 part, Pheretima 1-30 part, Olibanum 1-30 part, Poria 1-30 part, Fructus Akebiae 1-30 part, Herba Patriniae 1-30 part, Stigma Maydis 1-30 part, Fructus Forsythiae 1-30 part, Radix Scorzonerae austriacae 1-30 part, Herba monochasmatis 1-30 part, Concha Ostreae 1-30 part, Dioscorea zingiberensis 1-30 part, Ramulus Cinnamomi 1-30 part, Cornu Cervi Degelatinatum 1-30 part, Fructus Liquidambaris 1-30 part, Bulbus Fritillariae Uninbracteatae 1-30 part, Rhizoma Gymnadeniae 1-30 part, Spica Prunellae 1-30 part, Flos Genkwa 1-30 part.

3. according to a kind of Chinese medicine composition for the treatment of mastitis described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:

Herba Ainsliaeae Latifoliae 1-15 part, Radix Angelicae Sinensis 1-20 part, Fructus Lycii 1-20 part, Herba Inulae cappae 1-10 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-20 part, Herba Leonuri 1-30 part, Rhizoma Cyperi 1-10 part, Radix Platycodonis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-15 part, Ungula Sus domestica 1-15 part, Fructus Trichosanthis 1-30 part, Radix Astragali 1-30 part, Sonchus arvensis L. 1-30 part, Hedyotidis Diffusae 1-30 part, Radix Bupleuri 1-30 part, Semen Vaccariae 1-15 part, Herba Andrographis 1-15 part, Radix Salviae Miltiorrhizae 1-30 part, Flos Chrysanthemi Indici 1-30 part, Radix Paeoniae Alba 1-30 part, Pheretima 1-15 part, Olibanum 1-30 part, Poria 1-15 part, Fructus Akebiae 1-15 part, Herba Patriniae 1-30 part, Stigma Maydis 1-30 part, Fructus Forsythiae 1-30 part, Radix Scorzonerae austriacae 1-15 part, Herba monochasmatis 1-15 part, Concha Ostreae 1-15 part, Dioscorea zingiberensis 1-30 part, Ramulus Cinnamomi 1-15 part, Cornu Cervi Degelatinatum 1-15 part, Fructus Liquidambaris 1-15 part, Bulbus Fritillariae Uninbracteatae 1-30 part, Rhizoma Gymnadeniae 1-15 part, Spica Prunellae 1-30 part, Flos Genkwa 1-30 part.

4. a kind of Chinese medicine composition for the treatment of mastitis according to claims 1 to 3, is characterized in that: be made up of each component of following parts by weight:

Herba Ainsliaeae Latifoliae 1-10 part, Radix Angelicae Sinensis 1-10 part, Fructus Lycii 1-10 part, Herba Inulae cappae 1-5 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-5 part, Herba Leonuri 1-5 part, Rhizoma Cyperi 1-10 part, Radix Platycodonis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-10 part, Ungula Sus domestica 1-15 part, Fructus Trichosanthis 1-10 part, Radix Astragali 1-10 part, Sonchus arvensis L. 1-10 part, Hedyotidis Diffusae 1-10 part, Radix Bupleuri 1-10 part, Semen Vaccariae 1-15 part, Herba Andrographis 1-15 part, Radix Salviae Miltiorrhizae 1-10 part, Flos Chrysanthemi Indici 1-30 part, Radix Paeoniae Alba 1-30 part, Pheretima 1-15 part, Olibanum 1-30 part, Poria 1-15 part, Fructus Akebiae 1-15 part, Herba Patriniae 1-10 part, Stigma Maydis 1-30 part, Fructus Forsythiae 1-30 part, Radix Scorzonerae austriacae 1-15 part, Herba monochasmatis 1-10 part, Concha Ostreae 1-15 part, Dioscorea zingiberensis 1-30 part, Ramulus Cinnamomi 1-15 part, Cornu Cervi Degelatinatum 1-15 part, Fructus Liquidambaris 1-5 part, Bulbus Fritillariae Uninbracteatae 1-10 part, Rhizoma Gymnadeniae 1-10 part, Spica Prunellae 1-10 part, Flos Genkwa 1-10 part.

5. a kind of Chinese medicine composition for the treatment of mastitis according to Claims 1-4, is characterized in that: the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.

6., according to a kind of preparation method for the treatment of the Chinese medicine composition of mastitis described in claim 1 to 5, it is characterized in that: prepared by described capsule comprises the following steps:

A, adopt alcohol extracting method through filtering Herba Ainsliaeae Latifoliae, Radix Angelicae Sinensis, Fructus Lycii, Herba Inulae cappae, Flos Lonicerae, Herba Taraxaci, Herba Leonuri, Rhizoma Cyperi, Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae, concentrated, dry, pulverize, obtain powder;

B, by Ungula Sus domestica, Fructus Trichosanthis, the Radix Astragali, Sonchus arvensis L., Hedyotidis Diffusae, Radix Bupleuri, Semen Vaccariae, Herba Andrographis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi Indici, the Radix Paeoniae Alba, Pheretima, Olibanum, Poria, Fructus Akebiae adopt supercritical extraction, obtain supercritical extract, for subsequent use;

C, all the other crude drug decoct with water 2 times, after Aqueous extracts filters, and one-tenth extractum to be concentrated; Extractum Direct spraying is dried to spraying powder;

D, the canned capsule of medicated powder that above-mentioned steps is collected.

7. a kind of preparation method for the treatment of the Chinese medicine composition of mastitis according to claim 6, it is characterized in that: in described step a, described crude drug is put into container, adds 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use.

8. a kind of preparation method for the treatment of the Chinese medicine composition of mastitis according to claim 6, is characterized in that: in described step b, described crude drug is joined CO ₂in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 25MPa, temperature 60 C, CO ₂flow 3ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use.

9. a kind of preparation method for the treatment of the Chinese medicine composition of mastitis according to claim 6, it is characterized in that: will in described step c, get the water soaking 1-2 hour that crude drug adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, filter, be concentrated into extractum shape, extractum Direct spraying is dried to spraying powder.

10. a preparation method for the Chinese medicine composition of the treatment mastitis as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, comprising of its preparation process:

A, get crude drug and put into water and soak, heat is extracted 2 times, and becoming extractum shape, is component 1;

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.