CN1544019A - Chinese traditional medicine composition for treating arthralgia syndrome of cervical spondylopathy and its preparation - Google Patents

Abstract

The invention belongs to the field of pharmacy, in particular a traditional Chinese medicinal compound preparation for treating arthralgia syndrome vertebrae cervicales diseases, wherein the percentage by weight of the composition is 25%-35% of kudzuvine root, 10%-20% of ephedra sinica stapf, 10%-20% of cinnamon twig, 10%-20% of herbaceous peony, 10%-20% of glycyrrhiza uralensis fish extract and medicinal adjuvants.

Description

A kind of compound Chinese medicinal preparation and preparation method for the treatment of the arthragia syndrome type cervical spondylosis

Technical field

The present invention relates to Chinese medicine preparation and preparation method, be specifically related to a kind of compound Chinese medicinal preparation and preparation method for the treatment of the arthragia syndrome type cervical spondylosis.

Background technology

Cervical spondylosis belongs to motherland's medical science " arthromyodynia " category.Cervical spondylosis is because of the cervical intervertebral disk degenerative change causes intervertebral disk hernia, a series of clinical symptoms that occur thereby stimulation or compressing cervical spinal cord, nerve root etc. are organized and the syndrome of sign.Cervical spondylosis is tormenting the patient for a long time, brings white elephant also for family, society.According to investigation of clinical epidemiology in 1997, the prevalence of cervical spondylosis reached 11.37% at present.In case suffer from this disease, often touching difficulty more, symptom is diversification, influence cervical region nerve root, blood vessel, spinal cord, symptoms, particularly CSM patients such as dizziness, headache, neck aching pain in should and back, upper limb numbness, radiating pain, lower limb be sluggish occur, gently then the extremity flaccidity gives up, heavy then paralyse, be to influence people to enjoy one of healthy significant obstacle.This disease has become a kind of commonly encountered diseases and the frequently-occurring disease that accompanies with modern society, and in the morbidity spectrum of whole rachiopathy, cervical spondylosis has risen to main positions.But treat the arthragia syndrome type cervical spondylosis significant medicine of inefficacy still at present.

Summary of the invention

Technical problem to be solved by this invention is according to " element is asked a numbness opinion piece of writing " day: " wet three gas of wind and cold are assorted extremely; close and be numbness also " and " Treatise on Febrile and Miscellaneous Disease " hentriaconta-bar say: " TAI YANG syndrome; stiff nape and back is several; no perspiration but aversion to wind person; GEGEN TANG master it " etc. Chinese medical theory, the compound Chinese medicinal preparation of a kind of steady quality, determined curative effect, safe, inexpensive novel therapeutic arthragia syndrome type cervical spondylosis is provided.

The invention provides a kind of compound Chinese medicinal preparation for the treatment of the arthragia syndrome type cervical spondylosis and comprise by percentage by weight being that the extract and the pharmaceutic adjuvant of 25%～35% Radix Puerariae, 10%～20% Herba Ephedrae, 10%～20% Ramulus Cinnamomi, 10%～20% Radix Paeoniae, 10%～20% Radix Glycyrrhizae Preparata formed.

Another technical problem to be solved by this invention provides the preparation method of the compound Chinese medicinal preparation of above-mentioned treatment arthragia syndrome type cervical spondylosis.

The preparation method of compound Chinese medicinal preparation of the present invention comprises the following steps:

Get the Radix Puerariae of formula ratio, Herba Ephedrae, Ramulus Cinnamomi, Radix Paeoniae, Radix Glycyrrhizae Preparata decocts with water twice, merging filtrate, leave standstill, filter, filtrate is transferred PH10～12 with sodium hydroxide, extracted with diethyl ether, water layer water saturation n-butanol extraction, macroporous adsorbent resin on the gained extract, ethanol elution, collect eluent, respectively eluent and ether extraction liquid are evaporated to relative density 1.24～1.26 under 70 ℃ of conditions, vacuum drying is ground into fine powder, mix, formulation method is made various pills routinely, tablet, special-shaped tablet, granule, decoction, capsule and external are filmed, Emulsion, the cataplasma preparation.

Another technical problem to be solved by this invention provides the application of Chinese medicine preparation of the present invention in preparation treatment arthragia syndrome type cervical spondylosis medicine.(usage and consumption: pill, tablet (special-shaped tablet), granule, decoction, capsule are all oral, the amount that once is equivalent to the various dosage forms of 16.7g crude drug, 3 of 12 of pills, 3 in tablet (special-shaped tablet), 1 bag of granule, decoction 250ml, capsule, three times on the one, be 1 course of treatment January).

The Chinese medicine preparation that the present invention treats the arthragia syndrome type cervical spondylosis is according to " Treatise on Febrile and Miscellaneous Disease " hentriaconta-bar: " TAI YANG syndrome; stiff nape and back is several; no perspiration but aversion to wind person; GEGEN TANG master it " theory, in conjunction with piece relevant clinical and experimentation documents and materials surplus 1000, and develop on routine cervical spondylosis patient's clinical practice and more than 10 the experimentation basis surplus the treatment 10,000 in more than 10 year of this project seminar.

Through the arthromyodynia theory, the Zhong Jing experience of applying in a flexible way in conjunction with clinical practice for many years, thought that wind and cold wet type cervical spondylosis is the card of deficiency in origin and excess in superficiality in the present invention used for reference.Onset is many, and the visitor is in meridians, and is qi-blood disharmony because of the body void damp that is affected by the cold, and the muscle arteries and veins is unsuccessful and be disease.From the angle of differentiation of syndromes according to pathogeneses of QI and blood, just sick at gas, prolonged illness is at blood." sick at gas, that transfers defends ", " sick at blood, the network of accent " uses GEGEN TANG plus-minus treatment arthralgia due to wind-cold-dampness disease myelopathy clinically, obtained curative effect preferably.

(the prescription characteristics: Radix Puerariae, Herba Ephedrae, Ramulus Cinnamomi, Radix Paeoniae, Radix Glycyrrhizae Preparata are formed, effect with expelling wind and removing dampness cold expelling, promoting the flow of QI in the collateral by warming the meridian, harmonizing yingfen and weifen, Zhong Jingyong controls the chill exterior sun passages through which vital energy circulates of holding concurrently and loses in moistening and support they " stiff nape and back are several " card and pathogenic factor in the exterior is not understood card, cures mainly the arthralgia due to wind-cold-dampness disease myelopathy.GEGEN TANG is to subtract Ramulus Cinnamomi, Radix Paeoniae amount on the basis of guizhi decoction, reuses Radix Puerariae, Herba Ephedrae forms.Radix Puerariae promoting production of body fluid with drugs sweet in flavor and cold in nature in the side plays cloudy gas, inspires positive bright body fluid rising cloth to reach, and alleviates through the feeling pulse contracture priming neck that goes directly, the principal agent in the side of being; Herba Ephedrae opens natural fibre line of meat diaphoresis, but the Herba Ephedrae here is to be decocted first, and the power of diaphoresis weakens, and gets the merit of its diffusing heresy of activating yang, and it is auxilliary help Radix Puerariae to promote blood circulation rising the diffusing heresy in Tianjin; Guizhi decoction harmonizing yingfen and weifen QI and blood, it is eliminating evil among conditioning to reside, and makes heresy dispel and just do not hindering; Radix Glycyrrhizae in the guizhi decoction is held concurrently and can nurse one's health all medicines.All medicines share, and then can receive the heresy of loosing of stimulating the menstrual flow, yang invigorating Shu Mai, harmonizing yingfen and weifen, the merit of promoting flow of QI and blood.Radix Glycyrrhizae and Radix Paeoniae compatibility are peony and licorice decoction, sour and sweet drugs can transforme into YIN, and relieving spasm to stop pain, modern medicine confirms that also it has the effect of removing spasm.This shows that the square medicine of GEGEN TANG is formed and compatibility, the pathomechanism of feeling exopathogen matches with arthralgia due to wind-cold-dampness disease myelopathy disharmony of nutrient QI with defensive QI, again.It both by harmonizing yingfen and weifen, make normal circulation of qi and blood just to have held up, loosing the interspaces of skin and muscles, inducing QI blood evil to loose really is the good recipe of treatment cervical spondylosis with the profit muscle among setting upright again, the clinical treatment that often GEGEN TANG is used for cervical spondylosis has its theoretical basis.

Modern pharmacological research, Radix Puerariae contain multiple flavones ingredient, mainly contain daidzin (Daidzin), daidzein (Daidzein), puerarin (Puerarin) etc.Nakahata etc. have studied GEGEN TANG C6 rabbit neuroglial cytoma have been discharged prostaglandin E ₂Influence, think that GEGEN TANG has obvious inhibitory action to the arachidonic acid metabolic of neurogliocyte.Some single crude drugs of this side are to C ₆Rabbit neuroglial cytoma PGE ₂Release inhibitory action is also arranged.Can obviously suppress PGE as Radix Glycyrrhizae ₂Release, Radix Puerariae, Ramulus Cinnamomi and Radix Paeoniae Rubra moderate suppress PGE ₂Release.The GEGEN TANG of having studied Kurokawa etc. suppresses the inductive mice IL-1 of IFN α rising and alleviates influenza infection, and thinking does not influence the activity of IFN after GEGEN TANG is treated, but suppresses the generation of the inductive IL-1 α of IFN, thereby has suppressed cellular infiltration, and pneumonia is alleviated.Research is also found, though the treatment of GEGEN TANG has suppressed the generation of IL-1 α, does not destroy the system of defense of body, and the mistake that has just suppressed system of defense under the influenza infection situation is reacted by force.

Cervical intervertebral disk is the process of a gradual regression, the present invention by light, in, severe wind and cold is wet stimulates, find the various change procedures of arthragia syndrome type cervical spondylosis, further verified the cervical spondylosis theory of pathogenesis of " power is unbalance for earlier; static(al) is unbalance to be main ", illustrate that the wet stimulation of wind and cold can cause the musculi colli Cervical dynamic nonequilibrium, and then cause the standing balance imbalance, thereby make the generation and the development of arthragia syndrome type cervical spondylosis.Experimental results show that the inflammatory mediator level obviously raises in the animal regression intervertebral disc, produce autoimmune response, collagenase activity strengthens, extracellular matrix degradation.The present invention reaches the purpose of treatment cervical spondylosis by chemical inflammation and local immunoreation in increase intervertebral disc nutrition supply, the inhibition intervertebral disc.This theory is that the experimentation of intervertebral disc is laid a good foundation, and also provides theoretical foundation for non-operative treatment treatment cervical spondylosis.

Etiology angle from natural paathogenic factor, in the experimentation with the theoretical introducing of traditional Chinese medical science arthromyodynia cervical spondylosis, set up first light, in, severe wind-cold-dampness type cervical spondylosis animal model, in the arthragia syndrome type cervical spondylosis, seek the change procedure of intervertebral disc degeneration in various degree, thereby further disclosed the function assessment essence of arthragia syndrome type cervical spondylosis, made that the pathologic basis of this myelopathy standardizes more, standardization.By the research of " side-card-effect ", further the mechanism of action of the essence of announcement " arthromyodynia " relevant syndrome in cervical spondylosis and GEGEN TANG, guizhi decoction is enriched and developing Chinese medicine " arthromyodynia " theory.

Chinese medicine preparation with treatment cervical spondylosis of the present invention carries out relevant pharmacology, clinical research, and the result is as follows:

1. GEGEN TANG delays the research of intervertebral disc degeneration:

Set up the wet stimulating type cervical spondylosis animal model of wind and cold.The GEGEN TANG treatment can reduce intervertebral disc Miyamoto regression score value in various degree, can increase the blood vessel average area, does not relatively have significant difference (P＞0.05) with the wet group of wind and cold; GEGEN TANG reduces MMP-1, MMP-3 activity, does not relatively have significant difference (P＞0.05) with the wet stimulating group of wind and cold; GEGEN TANG reduces PGE in the regression intervertebral disc ₂, 6-K-PGF _{1 α}, TXB ₂Content, downward modulation MMP-1mRNA expresses, and downward modulation IL-1mRNA, iNOSmRNA express, and with the wet stimulating group of wind and cold significant difference (P＜0.01) are arranged relatively.GEGEN TANG raises TIMP-1mRNA and expresses, and raises TGF _βMRNA expresses, downward modulation TNF _αMRNA expresses, and with the wet group of wind and cold significant differences (P＜0.01) is arranged relatively, and GEGEN TANG reduces Fas to be expressed, and raises Bcl-2 and expresses, and does not relatively have significant difference (P＞0.05) with the wet stimulating group of wind and cold, reaches the purpose that delays intervertebral disc degeneration.

2. the research of GEGEN TANG function of promoting blood circulation to disperse blood clots:

Adopt circumgyration, heparin anti-coagulating 5ml measures at rotary full-automatic viscometer (LBY-N6 type).Can reduce the plasma viscosity ratio, packed cell volume fiber protein content (P＜0.05); Obviously reduce plasma viscosity ratio, packed cell volume (P＜0.01), obviously reduce fiber protein content (P＜0.01), it is unusual illustrate that GEGEN TANG is not only effectively corrected the hemorheology of rat model, and certain fine acting on of falling arranged.

3. the research of GEGEN TANG resist inflammation on repercussive function:

Scorching liquid induced mice auricle edema be can obviously suppress to cause, JINGFUKANG group and ibuprofen group (P＜0.01) are better than; The rat paw edema all has significant inhibitory effect due to the PARA FORMALDEHYDE PRILLS(91,95), causes scorching back 0.5,2,4,6,8,24h all has tangible resist inflammation on repercussive function (P＜0.01).

4. the research of GEGEN TANG analgesic effect:

The mice hot plate test shows that GEGEN TANG began to bring into play analgesic effect (P＜0.05) at 30 minutes, reaches peak value (P＜0.01) in 60 minutes, still has good analgesic effect (P＜0.01) in 120 minutes; The rat tail-flick test shows that GEGEN TANG has analgesic effect, pain relieving obviously (P＜0.01) behind 3h.

5. preliminary clinical research

Nearly 10 years is routine arthragia syndrome type cervical spondylosis patient surplus main formula treats 10,000 with GEGEN TANG clinically, receives better curative effect, has reduced operability.

Adopt randomized controlled, group forming criterion was treated 120 routine cervical spondylosis patients in 1: 1.Two groups after 8 weeks of treatment and 12 weeks, add up every curative effect index such as neck and shoulder part pain, upper limb numbness, squeeze test, brachial plexus distraction test respectively, carry out statistics comparison, GEGEN TANG treatment group is better than the JINGTONGLING matched group same period.Aggregate efficiency 86.7% after 8 weeks of GEGEN TANG treatment group treatment, treatment 12 all backs aggregate efficiencys 93.3% all are better than the JINGTONGLING matched group same period.

The clinical symptoms sign of table 1 GEGEN TANG group and JINGTONGLING group relatively

GEGEN TANG group (n=60) JINGTONGLING group (n=60)

P

Cure the produce effects enabledisable cure produce effects effectively/% is invalid

Neck-shoulder pain 14 24 14 84 20 16 20＜0.05

Control upper limb numbness 12 20 20 84 18 16 22＜0.05

Treat the prominent tenderness 12 14 10 24 8 12 10 30＜0.05 of neck

8 squeeze tests 14 10 10 26 4 14 10 32＜0.05

All brachial plexus distraction tests 14 14 6 26 6 12 12 30＜0.05

Tendon reflex 8 26 4 22 10 16 6 28＞0.05

Neck-shoulder pain 18 26 12 48 24 18 10＞0.05

Control upper limb numbness 18 26 12 4 12 22 16 10＞0.05

Treat the prominent tenderness 16 18 10 16 14 16 8 22＞0.05 of neck

12 squeeze tests 16 12 12 20 16 12 12 20＞0.05

All brachial plexus distraction tests 16 18 8 18 14 14 16 16＞0.05

Tendon reflex 8 18 14 20 12 16 12 20＞0.05

Table 1 shows:

1. after treating for 8 weeks, the GEGEN TANG group is compared with the JINGTONGLING group, at aspects such as neck and shoulder part pain, upper limb numbness, squeeze test, brachial plexus distraction tests significant difference (P＜0.05) is also arranged.There is not significant difference (P＞0.05) at tendon reflex aspect improving.Illustrate that the symptom and sign of GEGEN TANG group after 8 weeks of treatment obviously is better than the JINGTONGLING group aspect improving.

2. after treating for 12 weeks, the GEGEN TANG group is compared with the JINGTONGLING group, aspect dizzy, tinnitus improves, the difference (P＜0.01) of highly significant is arranged.Other disease total effective rate, the GEGEN TANG group all is higher than the JINGTONGLING group.

3. on the same group after 12 weeks of treatment, compare the time with 8 weeks of treatment, the GEGEN TANG group has significant difference (P＜0.05) aspect tendon reflex improves.The recovery of prompting tendon reflex may need the longer time.In the JINGTONGLING group, the partial symptoms sign also has significant improvement the (P＜0.05).

4. the JINGTONGLING group is after 12 weeks of treatment, and its symptom and sign just improves significantly, and (P＜0.05=points out its course of treatment with 12 week or longer being advisable.

Table 2 treatment 8 week, two groups of therapeutic evaluatioies in back

Group example number clinical cure (%) produce effects (%) is (%) invalid (%) total effective rate (%) effectively

GEGEN TANG group 60 10 (16.7) 20 (33.3) 22 (36.7) 8 (13.3) 86.7

JINGTONGLING group 60 8 (13.3) 16 (26.7) 18 (30.0) 18 (30.0) 70.0

GEGEN TANG group and JINGTONGLING group compare: P＜0.05

Table 3 treatment 12 week, two groups of therapeutic evaluatioies in back

Group example number clinical cure (%) produce effects (%) is (%) invalid (%) total effective rate (%) effectively

GEGEN TANG group 60 14 (23.3) 22 (36.7) 20 (33.3) 4 (6.7) 93.3

JINGTONGLING group 60 8 (13.3) 16 (26.7) 24 (40.0) 12 (20.0) 80.0

GEGEN TANG group and JINGTONGLING group compare: P＜0.05

Table 2,3 shows:

1. the GEGEN TANG group was compared with the JINGTONGLING group after 8 weeks of treatment, the existing very notable difference (P＜0.01) of its effective percentage.Show that treatment by Chinese herbs is to suit a course of treatment with 8 weeks.

2. GEGEN TANG group and JINGTONGLING group are continuing treatment to 12 weeks, and its effective percentage is compared, and the GEGEN TANG group still is higher than the JINGTONGLING group.Brief summary:

1. Chinese drug-treated group and JINGTONGLING group all have and improve each symptom and sign and certain effective percentage arranged.The Chinese drug-treated group curative effect was advisable with 8 weeks, and JINGTONGLING group curative effect is with 12 week or longer being advisable.

Chinese drug-treated group 8 the week and 12 weeks after efficacy evaluation in all be significantly higher than the JINGTONGLING group (P＜0.05=, Chinese drug-treated group is described, and not only curative effect is good, and the course of treatment also corresponding weak point.

3. among the GEGEN TANG group patient, there are 2 people stomach discomfort to occur, advise behind the one after each meal and promptly eliminate, among the JINGTONGLING group patient, there are 6 people stomach discomfort to occur, still have 3 people's stomach symptoms not eliminate after advising one after each meal, dizzy sx appears after other has 4 people to take medicine, and may be owing to contain the medicine that expands blood vessel.

4.X line situation of change: the GEGEN TANG group is after 8 weeks of treatment and 12 weeks, and only physiologic radian has the improver to be respectively 4 people and 2 people; The JINGTONGLING group is respectively 2 people and 3 people, no significant change before and after other X line sign treatment.

Along with the modern society rhythm of life is accelerated, the working method of bowing crowd increases, being extensive use of of computer, air-conditioning, refrigerator, automobile, and the probability that people suffer the wind-cold damp pathogen invasion and attack, bend neck all increases considerably, and causes the prevalence of cervical spondylosis constantly to rise.The present invention treats the compound Chinese medicinal preparation of cervical spondylosis, by relieving the exterior syndrome by diaphoresis, born fluid, moisten through the feeling pulse effect, obviously alleviate or eliminate symptoms such as arthragia syndrome type cervical spondylosis patient neck arm pain, radiating pain, numbness, dysfunction, be specially adapted to treatment of diseases such as each myelopathy, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, sciatica, improve cure rate.The present invention treats that the compound Chinese medicinal preparation of cervical spondylosis is evident in efficacy, safety non-toxic, taking convenience, and the treatment of cervical spondylosis is had good social benefit and economic benefit.

The specific embodiment

Embodiment 1

Medication preparation: get 10Kg Radix Puerariae, 6Kg Herba Ephedrae, 8Kg Ramulus Cinnamomi, 8Kg Radix Paeoniae, 8Kg Radix Glycyrrhizae Preparata and add the 200L decocting and boil twice, merging filtrate, leave standstill, filter, filtrate is transferred PH11 with sodium hydroxide, extracted with diethyl ether, water layer water saturation n-butanol extraction, macroporous adsorbent resin on the gained extract, ethanol elution, collect eluent, respectively eluent and ether extraction liquid are evaporated to relative density 1.24～1.26 (70 ℃), vacuum drying, be ground into fine powder, add adjuvant, mixing is made the watered pill (specification: 0.15 gram/ball).

Embodiment 2

Medication preparation: get 12Kg Radix Puerariae, 8Kg Herba Ephedrae, 6Kg Ramulus Cinnamomi, 6Kg Radix Paeoniae, 8Kg Radix Glycyrrhizae Preparata and add the 200L decocting and boil twice, merging filtrate, leave standstill, filter, filtrate is transferred PH11 with sodium hydroxide, extracted with diethyl ether, water layer water saturation n-butanol extraction, macroporous adsorbent resin on the gained extract, ethanol elution is collected eluent, respectively eluent and ether extraction liquid are evaporated to relative density 1.24～1.26 (70 ℃), vacuum drying is ground into fine powder, adds adjuvant, mixing, tabletting, coating is made tablet (specification: 0.12 gram/sheet).

Embodiment 3

Medication preparation: get 10Kg Radix Puerariae, 8Kg Herba Ephedrae, 6Kg Ramulus Cinnamomi, 8Kg Radix Paeoniae, 8Kg Radix Glycyrrhizae Preparata and add the 200L decocting and boil twice, merging filtrate leaves standstill, and filters (specification: the 250ml/ bottle).

Embodiment 4

Medication preparation: get 14Kg Radix Puerariae, 8Kg Herba Ephedrae, 6Kg Ramulus Cinnamomi, 6Kg Radix Paeoniae, 6Kg Radix Glycyrrhizae Preparata and decoct with water twice, merging filtrate, leave standstill, filter, filtrate is transferred PH12 with sodium hydroxide, extracted with diethyl ether, water layer water saturation n-butanol extraction, macroporous adsorbent resin on the gained extract, ethanol elution, collect eluent, respectively eluent and ether extraction liquid are evaporated to relative density 1.24～1.26 (70 ℃), vacuum drying, be ground into fine powder, add adjuvant, mixing, system granule (specification: 5 gram/bags).

Embodiment 5

Medication preparation: get 14Kg Radix Puerariae, 4kg Herba Ephedrae, 8Kg Ramulus Cinnamomi, 6Kg Radix Paeoniae, 8Kg Radix Glycyrrhizae Preparata and add the 200L decocting and boil twice, merging filtrate, leave standstill, filter, filtrate is transferred PH12 with sodium hydroxide, extracted with diethyl ether, water layer water saturation n-butanol extraction, macroporous adsorbent resin on the gained extract, ethanol elution, collect eluent, respectively eluent and ether extraction liquid are evaporated to relative density 1.24～1.26 (70 ℃), vacuum drying, be ground into fine powder, add adjuvant, mixing, encapsulated (specification: the 250mg/ grain).

Embodiment 6

Open * *, woman, 50 years old.Neck pain is stiff, and disease of hand 2 years is surplus.The neck pain that started before 2 years is stiff not to relax, and increases the weight of gradually, shows pain unbearably, and more so pain caused and had difficulty in going to sleep night.And disease of hand is arranged, dizzy fear of cold, two just still can, stomach discomfort.Check: neck limitation of activity (+), the cervical vertebra tenderness (+++), Hoffman ' s (±), the greasy in vain matter purple of tongue, stringy and thready pulse.Take each 12 of Radix Puerariae ball, every day 3 times, totally 14 days.During further consultation, pain is slow, but numbness of hand still has the thin fur thready pulse.Former method is come in and gone out, and continues to take each 12 of Radix Puerariae ball, and every day 3 times, totally 14 days, when examining, symptom was slow again.

Embodiment 7

The king * *, man, 47 years old.The main suit: neck-shoulder pain 5 years, accompany right hemianesthesia, the right hand is unable, holds the thing shakiness, and difficulty in walking catches cold and increases the weight of.Check: pain behind the neck, cervical vertebra tenderness (+), neck limitation of activity (±), Hoffman ' s (±), 3 grades of RHGs, difficulty in walking, the loose stool frequent micturition, sleeping night, it is peaceful to lose.MRI takes the photograph the sheet inspection and shows: the C5/6 annuler bulge, root compression is obvious.Greasy and thin fur, deep-thready pulse.Dialectical: cervical spondylotic radiculopathy.The rule of treatment: expelling wind and removing dampness cold expelling, promoting the flow of QI in the collateral by warming the meridian, harmonizing yingfen and weifen.Take 3 of Radix Puerariae sheets, 3 times on the one, after totally 14 days, body pine limb is light, and the right hand is numb to be reduced.Recheck: right hand muscular strength is normal, and Hoffman ' sShi levies (-), cervical vertebra tenderness (+).Obey 3 of Radix Puerariae sheets again, 3 times on the one, after totally 14 days, all symptoms all slow and separate.

Embodiment 8

Flood * *, woman, 31 years old.Head examines the date: on July 8th, 1999.The main suit: neck pain, held up right shoulder 1 year.History of present illness: over one year, patient's neck pain, hold up right shoulder, the time outbreak arranged.During beginning, only control, and the attack times frequency is more and more higher, often brings out after being affected by the cold with " stiff neck ".Neck and right shoulder muscle are stiff, send out deadlock, change also difficulty of neck.Right shoulder is held up and is made picotement.Check: cervical vertebra both sides muscular tone, stiff, C _5～6, C _6～7Tenderness (+) between spinous process; Hoffman levies (-).The X line shows: the cervical vertebrae physiological radian becomes straight.Thin fur, thready pulse is tight.Dialectical: wind chill blockage, battalion defends and becomes estranged.The rule of treatment: dispelling wind collateral dredging and battalion's expelling pathogenic factors from muscles.Prescription: GEGEN TANG plus-minus.Two examine: on August 6th, 99.All illness are recovered behind the medicine, neck tenderness (-), and musculi colli has not had stiff stiff sense.Curative effect is consolidated for 7 doses in the place ahead.

Embodiment 9

The palace * *, man, 45 years old.Neck pain is stiff, and disease of hand 5 years is surplus.The neck pain that starts is stiff not to relax, and increases the weight of gradually, and pain has difficulty in going to sleep unbearably, with disease of hand, and fear of cold, stomach discomfort.Check: neck limitation of activity (+) cervical vertebra tenderness (+), pharyngeal congestion (++), Hoffman ' s (+), tongue is greasy in vain, stringy pulse.Take 1 bag of Radix Puerariae granule, every day 3 times, totally 14 days.During further consultation, pain is slow, continues to take 1 bag of Radix Puerariae granule, every day 3 times, totally 14 days.When examining, symptom is slow again.

Embodiment 10

Yellow *, man, 47 years old.Head examines the date: on April 19th, 1999.The main suit: neck pain, had sore throat for two weeks.No trauma history.History of present illness: the patient came in two weeks, and neck is held up pain, and it is miserable to relate to left elbow, changes the neck difficulty.Consciously behind the operating computer of bowing for a long time, causing.Pain exaggerated by catching cold, it is light to get hot then alleviation of pain.Two just still can, sleep night and feel unwell, stomach is received fair.Check: the musculi colli tensity is slightly high, the other tenderness (+) of cervical vertebra, and more extensive, C _2～3Transverse process tenderness (+), Hoffman ' s levies (-).The X line shows: the cervical vertebrae physiological radian becomes straight, C _2～7Hyperosteogeny of cervical vertebra, C _3～4, C _4～5, C _5～6, C _6～7Intervertebral space all has narrow in various degree.Yellow, greasy and thin fur, matter purple, thready and stringy pulse.Take 3 of radix puerariae capsules, 3 times on the one, after totally 14 days, cervicodynia alleviation uncomfortable in chest, body pine limb is light, and two is just normal.Recheck: muscular strength is normal, and Hoffman ' sShi levies (-), cervical vertebra tenderness (+).Obey 3 of radix puerariae capsules again, 3 times on the one, after totally 14 days, all symptoms all slow and separate.

Claims (3)

1. compound Chinese medicinal preparation for the treatment of the arthragia syndrome type cervical spondylosis is characterized in that it is that the extract and the pharmaceutic adjuvant of 25%～35% Radix Puerariae, 10%～20% Herba Ephedrae, 10%～20% Ramulus Cinnamomi, 10%～20% Radix Paeoniae, 10%～20% Radix Glycyrrhizae Preparata formed that this compound Chinese medicinal preparation comprises by percentage by weight.

2. an a kind of preparation method for the treatment of the compound Chinese medicinal preparation of arthragia syndrome type cervical spondylosis as claimed in claim 1 is characterized in that this method comprises the following steps:

Get the Radix Puerariae of formula ratio, Herba Ephedrae, Ramulus Cinnamomi, Radix Paeoniae, Radix Glycyrrhizae Preparata decocts with water twice, merging filtrate, leave standstill, filter, filtrate is transferred PH10～12 with sodium hydroxide, extracted with diethyl ether, water layer water saturation n-butanol extraction, macroporous adsorbent resin on the gained extract, ethanol elution, collect eluent, respectively eluent and ether extraction liquid are evaporated to relative density 1.24～1.26 under 70 ℃ of conditions, vacuum drying is ground into fine powder, mix, formulation method is made various pills routinely, tablet, special-shaped tablet, granule, decoction, capsule and external are filmed, Emulsion, the cataplasma preparation.

3. one kind comprises by percentage by weight being the application of extract in the medicine of preparation treatment arthragia syndrome type cervical spondylosis of 25%～35% Radix Puerariae, 10%～20% Herba Ephedrae, 10%～20% Ramulus Cinnamomi, 10%～20% Radix Paeoniae, 10%～20% Radix Glycyrrhizae Preparata.