CN1177600C - Chinese medicine compound preparation for treating cervical spondylosis, and preparing process thereof - Google Patents
Chinese medicine compound preparation for treating cervical spondylosis, and preparing process thereof Download PDFInfo
- Publication number
- CN1177600C CN1177600C CNB011265590A CN01126559A CN1177600C CN 1177600 C CN1177600 C CN 1177600C CN B011265590 A CNB011265590 A CN B011265590A CN 01126559 A CN01126559 A CN 01126559A CN 1177600 C CN1177600 C CN 1177600C
- Authority
- CN
- China
- Prior art keywords
- preparation
- cervical spondylosis
- chinese medicinal
- artificial
- moschus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a Chinese medicinal compound preparation for treating cervical spondylosis and a preparation method. The preparation is composed of the following active ingredients (by weight percentage): 30 to 47% of astragalus root, 0.01 to 0.1% of artificial moschus, 17 to 20% of hemlock parsley, 17 to 25% of orientvine, 17 to 25% of Radix Stephaniae Tetrandrae and 0.1 to 1.0% of artificial bezoar. The preparation can be in the form of pills, tablets, granules, mixture, capsules, coating films for external application, etc. The Chinese medicinal compound preparation for treating cervical spondylosis in the present invention obviously relieves or eliminates various symptoms of patients with cervical spondylosis through benefiting qi, removing stasis, removing dampness by diuresis, dredging channels, relieving inflammation and alleviating pain, and has especially higher cure rate for treating various diseases, such as cervical spondylosis, periarthritis of shoulder, prolapse of lumbar intervertebral disc, gonarthritis, sciatica, etc. The Chinese medicinal compound preparation for treating cervical spondylosis in the present invention has the advantages of obvious curative effect, safety, no toxic action and convenient oral administration, and achieves favorable social benefit and economic benefit in treating cervical spondylosis.
Description
Technical field
The present invention relates to Chinese medicine preparation and preparation method, be specifically related to a kind of compound Chinese medicinal preparation and preparation method for the treatment of cervical spondylosis.
Background technology
According to investigation of clinical epidemiology in 1997, the prevalence of cervical spondylosis reached 11.37% at present.In case suffer from this disease, often touching difficulty more, symptom is diversification, influences cervical region nerve root, blood vessel, spinal cord, symptoms such as dizziness, headache, neck aching pain in should and back, upper limb numbness, radiating pain, lower limb be sluggish occur, CSM patients particularly, gently then the extremity flaccidity is useless, and is heavy then paralyse, and not only torments the patient for a long time, bringing heavy financial burden also for whole family, society, is to influence people to enjoy one of healthy significant obstacle.This disease has become a kind of commonly encountered diseases and the frequently-occurring disease that accompanies with modern society, and in the morbidity spectrum of whole rachiopathy, cervical spondylosis has risen to main positions.But treat the cervical spondylosis significant medicine of inefficacy still at present.
Summary of the invention
Technical problem to be solved by this invention is the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs theory according to the traditional Chinese medical science " is that elder generation, the expectorant stasis of blood are taken into account based on gas, with blood ", and the compound Chinese medicinal preparation of a kind of steady quality, determined curative effect, safe, inexpensive novel therapeutic cervical spondylosis is provided.
The active component prescription of the compound Chinese medicinal preparation of treatment cervical spondylosis disclosed by the invention is that the 30-47% Radix Astragali, 0.01-0.1% artificial Moschus, 17-20% Rhizoma Chuanxiong, 17-25% Caulis Sinomenii, 17-25% Radix Stephaniae Tetrandrae and 0.1-1.0% artificial Calculus Bovis form by percentage by weight.
Above-mentioned active component prescription can match with a certain proportion of common medicinal supplementary material, makes various pills, tablet (comprising special-shaped tablet), granule, mixture, capsule and external preparation such as film.
Another technical problem to be solved by this invention provides the preparation method of the compound Chinese medicinal preparation of above-mentioned treatment cervical spondylosis.
The preparation method of the compound Chinese medicinal preparation of treatment cervical spondylosis disclosed by the invention comprises the following steps:
(1) preparation of active ingredient extractum
Rhizoma Chuanxiong, the Radix Astragali, Radix Stephaniae Tetrandrae, the Caulis Sinomenii of getting recipe quantity decoct with water twice, filter, and merging filtrate leaves standstill, and filter, and concentrating under reduced pressure promptly gets extractum;
(2) preparation of mixture
Get above-mentioned extractum, press recipe quantity and add artificial Moschus and artificial Calculus Bovis, water is adjusted to volume required, promptly;
(3) preparation of pill, tablet, capsule
Get above-mentioned extractum, vacuum drying is ground into fine powder, presses recipe quantity and adds artificial Moschus's fine powder, artificial Calculus Bovis's fine powder, and mixing adds proper pharmaceutical excipients, crosses the 12-20 mesh sieve and gets the semi-finished product powder; The semi-finished product direct powder compression is promptly got tablet; The semi-finished product powder packed into promptly get capsule in the hungry area shell; The semi-finished product powder is granulated, and repressed method is made the ball coating and is promptly got pill;
(4) preparation of granule
Get above-mentioned extractum, add proper pharmaceutical excipients, make soft material, pushed the 12-20 mesh sieve with granulator and become granule, be drying to obtain;
(5) preparation of liniment
Press recipe quantity above-mentioned Rhizoma Chuanxiong, the Radix Astragali, Radix Stephaniae Tetrandrae, Caulis Sinomenii, artificial Moschus and artificial Calculus Bovis are used alcohol dipping 2 hours, percolation is collected the liquid of filtering, and adds dissolved polyvinyl alcohol 50g and acetone, and mixing adds a certain amount of 75% ethanol and promptly gets liniment.
Another technical problem to be solved by this invention provides the application of Chinese medicine preparation of the present invention in preparation treatment cervical spondylosis medicine.
The therapeutic dose that the present invention treats the compound Chinese medicinal preparation of cervical spondylosis is oral three times on the one, and every day, total dose was equivalent to crude drug 16.7-55g, and one month is a course of treatment.
The Chinese medicine preparation (stilbene Moschus moschiferous neck health ball) that the present invention treats cervical spondylosis is the differentiation of tcm theory according to " based on gas; with blood is earlier; the expectorant stasis of blood is taken into account ", in conjunction with routine cervical spondylosis patient's clinical practice surplus the treatment 10,000 in more than 10 years with repeatedly develop on the experimentation basis.Stilbene Moschus moschiferous neck health ball is made up of 6 flavor Chinese medicines such as the Radix Astragali, artificial Moschus, has the effect of benefiting qi and removing blood stasis, dampness removing collateral dredging, anti-inflammatory analgetic, cures mainly blood stasis due to qi deficiency or double phlegm-damp resistance network myelopathy.The Radix Astragali, benefiting QI for strengthening the superficies, the diuretic detumescent, we draw the tonification effect that the Radix Astragali is monarch drug performance we.Get the successive dynasties that act as of its QI invigorating tonify deficiency and assert " Japan hanako materia medica ": " Radix Astragali helps the gas strengthening bone and muscle, attacks the meat addiction of enriching blood brokenly "; " book on Chinese herbal medicine converges and says ": " arresting sweating is defended in the Radix Astragali, tonifying the lung spleen invigorating in fact, and wind dispelling fortune poison also.The disease of harmful wind, invasion of vessels partially, and brothers are with the person, the Radix Astragali can flourish muscles and bones." artificial Moschus, the key of being open to the custom, on reach skin, in go into bone marrow, the blood circulation promoting and dispersing pathogen accumulation pain relieving is ministerial drug.The Rhizoma Chuanxiong promoting flow of QI and blood, wind-expelling pain-stopping." herbal classic " said: " main apoplexy is gone into brain, headache, arthralgia due to cold, clonic spasm of the muscle emergency ...." with the artificial Moschus be ministerial drug altogether.Radix Stephaniae Tetrandrae, expelling wind and removing dampness, inducing diuresis to remove edema pain relieving; Caulis Sinomenii is bitter flat, wind-damp dispelling, diuresis, dispelling the wind and dampness pathogens arthralgia pain, the arthroncus of knee; Radix Stephaniae Tetrandrae, Caulis Sinomenii are adjuvant drug altogether, and artificial Calculus Bovis's removing heat-phlegm sore-throat relieving is messenger drug.Dialectical by theory of Chinese medical science, cervical spondylosis is a cervical region muscle and tendon injury disease, belongs to the arthromyodynia category.The cause of disease of primary disease is wind-cold damp pathogen outside, interior be phlegm-damp, blood stasis, sick originally is deficiency of the liver and kindey, deficiency of qi and blood.Inside and outside combined pathogens, deficiency in origin and excess in superficiality is fallen ill eventually.Differentiation of tcm theory according to ", being that phlegm-damp is taken into account earlier " with blood based on gas, the Radix Astragali, Moschus are respectively monarch drug and valuable ministerial drug in this prescription, so getting " stilbene Moschus moschiferous neck health ball " is the title of this prescription, has both shown its main component and compatibility characteristics, has reflected its dosage form characteristic again.
It is considered herein that the cervical vertebra biomechanics unbalance be the main mechanism of cervical vertebra regression, wherein " power is unbalance is earlier, static(al) is unbalance to be main ", experimental results show that the inflammatory mediator level obviously raises in the animal regression intervertebral disc, produce autoimmune response, collagenase activity strengthens, extracellular matrix degradation.The present invention reaches the purpose of treatment cervical spondylosis by chemical inflammation and local immunoreation in increase intervertebral disc nutrition supply, the inhibition intervertebral disc.
The traditional Chinese medical science thinks that " blood stasis due to qi deficiency, deficiency in origin and excess in superficiality " is the basic reason of intervertebral disc degradation in addition, " vim and vigour discord; all kinds of diseases and ailments are to change and give birth to ", " deficiency of vital energy is this, and blood stasis is mark ", the deficiency of vital energy then promotes unable, blood deficiency is then stagnant and not all right, not removing of congestion, fresh blood are not then given birth to, and have caused " not Rong Ze pain " and " stagnation of QI and blood may bring about pain ".The present invention is by " benefiting qi and removing blood stasis, control combination, giving consideration to both the incidental and fundamental ", for non-operative treatment treatment cervical spondylosis has been opened up new thinking.
Chinese medicine preparation (stilbene Moschus moschiferous neck health ball) with treatment cervical spondylosis of the present invention carries out relevant pharmacology, toxicity, clinical research, and the result is as follows:
1. stilbene Moschus moschiferous neck health ball delays the research of intervertebral disc degeneration:
Set up the unbalance property of the dynamic and static power of rat model of intervertebral disc degradation.(5.13g crude drug/kg/d), high (degree that the dosage group of 10.26g crude drug/kg/d) delays intervertebral disc degeneration is better than JINGFUKANG group, ibuprofen group (P＜0.01) in the stilbene Moschus moschiferous neck health ball; Middle and high dosage reduces PGE in the rat cervical intervertebral disk
2, 6-ketone-PGF
2 αContent is better than JINGFUKANG group (P＜0.01); Low dosage (2.57g crude drug/kg/d) can reduce PGE in the rat cervical intervertebral disk
2Content (P＜0.05); Middle and high dosage can obviously reduce MMP-1 content in the rat cervical intervertebral disk (P＜0.01); Obviously reduce IgG, IgM content (P＜0.01) in the rat cervical intervertebral disk.Illustrate that stilbene Moschus moschiferous neck health ball can delay the cartilage endplate calcification, increase the intervertebral disc nutrition supply; Can raise the expression of somatomedin mRNA such as IGF-I in the rat cervical intervertebral disk, the expression of TNF-α, bFGFmRNA in the downward modulation nucleus pulposus cell: can reduce PGE2 in the rat cervical intervertebral disk, 6-ketone-PGF
2 αThe activity of content and collagenase reduces the degraded of intervertebral disc cells epimatrix; Can reduce Fas, Caspase8 and express, the expression of increasing Bcl-2 prevents the intervertebral disc cells apoptosis, and cell is in the suitable survival condition, reaches the purpose that delays intervertebral disc degeneration.
2. the research of stilbene Moschus moschiferous neck health ball function of promoting blood circulation to disperse blood clots:
Adopt circumgyration, heparin anti-coagulating 5ml measures at rotary full-automatic viscometer (LBY-N6 type).Low amount group can reduce the whole blood height and cut viscosity content, and plasma viscosity ratio (P＜0.05) is near the ibuprofen group; Middle dosage group can reduce the plasma viscosity ratio, packed cell volume fiber protein content (P＜0.05); High dose can reduce that whole blood low is cut viscosity, the whole blood height is cut viscosity (P＜0.05); Obviously reduce plasma viscosity ratio, packed cell volume (P＜0.01), obviously reduce fiber protein content (P＜0.01), it is unusual illustrate that stilbene Moschus moschiferous neck health ball is not only effectively corrected the hemorheology of rat model, and certain fine acting on of falling arranged.
3. the research of neck health ball resist inflammation on repercussive function:
Mice 7.70g crude drug/kg/d, 15.40g crude drug/kg/d can obviously suppress to cause scorching liquid induced mice auricle edema, are better than JINGFUKANG group and ibuprofen group (P＜0.01).The rat paw edema all has significant inhibitory effect due to rat 5.13g crude drug/kg/d, the 10.26g crude drug/kg/d PARA FORMALDEHYDE PRILLS(91,95), causes scorching back 0.5,2,4,6,8,24h all has tangible resist inflammation on repercussive function (P＜0.01).
4. the research of stilbene Moschus moschiferous neck health ball analgesic effect:
The mice hot plate test shows that stilbene Moschus moschiferous neck health ball 7.70g crude drug/kg/d, 15.40g crude drug/kg/d have obvious analgesic effect, 7.70g crude drug/kg/d began to bring into play analgesic effect (P＜0.05) at 60 minutes, reached peak value (P＜0.01) in 90 minutes: 15.40g crude drug/kg/d began to bring into play analgesic effect (P＜0.05) at 30 minutes, still had good analgesic effect (P＜0.01) in 120 minutes; The rat tail-flick test shows that stilbene Moschus moschiferous neck health ball 5.13g crude drug/kg/d, 10.26g crude drug/kg/d have analgesic effect, pain relieving obviously (P＜0.01) behind 3h.
5. acute toxicity testing:
Kunming mice more than 321.92g crude drug/kg/d, is more than 444 times of clinical people's consumption to the maximum tolerated dose of stilbene Moschus moschiferous neck health ball, and the administration treated animal is not seen and is poisoned to death.
6. long term toxicity test:
The rat long term toxicity test, divide basic, normal, high low three dosage groups, be respectively 11.47,46.22,186.21g crude drug/kg/d, respectively be equivalent to intend 11 times, 45 times and 181 times with clinical dosage, in reaching the administration process in 15 weeks and convalescent period, rat is movable from start to finish normal, any symptom or death do not occur; Hematological examination, blood biochemical are learned results such as inspection, routine urianlysis, pathological examination and are shown stilbene Moschus moschiferous neck health ball successive administration after 15 weeks, do not see and the obvious relevant toxic action of medicine.Illustrate that stilbene Moschus moschiferous neck health ball does not have obvious long term toxicity effect.
7. preliminary clinical research:
Routine cervical spondylosis patient surplus treating 10,000 with stilbene Moschus moschiferous neck health soup clinically in nearly 10 years receives better curative effect, has reduced operability.Adopt single blind random packet principle to treat 172 routine cervical spondylosiss, in 4 weeks of medication, aggregate efficiency 92.4% is better than JINGFUKANG matched group (72.1%) in the recent period, P＜0.01, and with matched group significant difference is being arranged more all aspect cure rate and the total effective rate.Behind age layering and Chinese medical discrimination typing, find, this side treatment greater than 45 years old patient and (or) have patient's curative effect of Qi deficiency blood stasis type better.Stilbene Moschus moschiferous neck health soup is being better than the JINGFUKANG group aspect symptom, the signs such as alleviation neck shoulder and back ache, numbness, bottleneck throat infection, positional vertigo motion or sensory disturbance, Hoffman ' s, brachial plexus distraction test.
Along with modern society's rhythm of life is accelerated, the working method of bowing crowd increases, being extensive use of of computer, air-conditioning, refrigerator, automobile, the probability that people suffer the wind-cold damp pathogen invasion and attack, bend neck and cervical region wound all increases considerably, and causes the prevalence of cervical spondylosis constantly to rise.The present invention treats the compound Chinese medicinal preparation of cervical spondylosis, by benefiting qi and removing blood stasis, dampness removing collateral dredging, anti-inflammatory analgetic, obviously alleviate or eliminate symptoms such as cervical spondylosis patient neck arm pain, radiating pain, numbness, dysfunction, be specially adapted to treatment of diseases such as each myelopathy, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, gonarthritis, sciatica, improve cure rate.The present invention treats that the compound Chinese medicinal preparation of cervical spondylosis is evident in efficacy, safety non-toxic, taking convenience, and the treatment of cervical spondylosis is had good social benefit and economic benefit.
The specific embodiment
The preparation of embodiment one active ingredient extractum
Prescription: Rhizoma Chuanxiong 360g, Radix Astragali 720g, Radix Stephaniae Tetrandrae 300g, Caulis Sinomenii 420g, artificial Moschus 1g, artificial Calculus Bovis 15g
Rhizoma Chuanxiong, the Radix Astragali, Radix Stephaniae Tetrandrae, the Caulis Sinomenii of getting recipe quantity decoct with water twice, filter, and merging filtrate leaves standstill, and filter, and are evaporated to finite concentration, and adding artificial Moschus, artificial Calculus Bovis promptly get extractum.
The preparation of embodiment two mixture
Prescription: Rhizoma Chuanxiong 360g, Radix Astragali 720g, Radix Stephaniae Tetrandrae 300g, Caulis Sinomenii 420g, artificial Moschus 1g, artificial Calculus Bovis 15g
Get Rhizoma Chuanxiong, the Radix Astragali, Radix Stephaniae Tetrandrae, the Caulis Sinomenii of recipe quantity and make extractum by the method for embodiment one, add artificial Moschus and artificial Calculus Bovis, add 1% aspartame sugar, water is adjusted to 1600ml, that is, make every ml contain crude drug 1.135g.
The preparation of embodiment three pills
Prescription: Rhizoma Chuanxiong 308g, Radix Astragali 762g, Radix Stephaniae Tetrandrae 419g, Caulis Sinomenii 316g, artificial Moschus 1.5g, artificial Calculus Bovis 9.5g, carboxymethyl starch sodium 90g, sodium bicarbonate 18g
Make extractum by embodiment one method; vacuum drying; be ground into fine powder, press recipe quantity and add artificial Moschus's fine powder, artificial Calculus Bovis's fine powder, mixing; add carboxymethyl starch sodium, sodium bicarbonate; mixing is with alcohol granulation (12-14 order), particle drying; repressed method is made the ball coating promptly, makes every 1000g pill contain crude drug 94.4g.
The preparation of embodiment four tablets
Prescription: Rhizoma Chuanxiong 308g, Radix Astragali 817g, Radix Stephaniae Tetrandrae 308g, Caulis Sinomenii 370g, artificial Moschus 1g, artificial Calculus Bovis 12f, carboxymethyl starch sodium 90g, sodium bicarbonate 18g
Make granule by the tripartite method of embodiment, with the granule direct compression promptly, make every to contain crude drug 0.65g.
The preparation of embodiment five capsules
Prescription: Rhizoma Chuanxiong 360g, Radix Astragali 720g, Radix Stephaniae Tetrandrae 300g, Caulis Sinomenii 420g, artificial Moschus 1g, artificial Calculus Bovis 15g, starch 90g
Make fine powder by the tripartite method of embodiment, press recipe quantity and add artificial Moschus, artificial Calculus Bovis's fine powder, mixing promptly gets capsule in the hungry area shell of packing into, makes every capsules contain crude drug 0.3g.
The preparation of embodiment hexamer agent
Prescription: Rhizoma Chuanxiong 360g, Radix Astragali 720g, Radix Stephaniae Tetrandrae 300g, Caulis Sinomenii 420g, artificial Moschus 1g, artificial Calculus Bovis 15g, Icing Sugar 460g
Make extractum by embodiment one method, add 50% Icing Sugar, mixing is made soft material, pushes the 12-20 mesh sieve with granulator and becomes granule, and vacuum drying promptly makes every 10g granule contain crude drug 18.16g.
The preparation of embodiment seven liniment
Prescription: Rhizoma Chuanxiong 360g, Radix Astragali 720g, Radix Stephaniae Tetrandrae 300g, Caulis Sinomenii 420g, artificial Moschus 1g, artificial Calculus Bovis 15g, polyvinyl alcohol 50g
Press recipe quantity above-mentioned Rhizoma Chuanxiong, the Radix Astragali, Radix Stephaniae Tetrandrae, Caulis Sinomenii, artificial Moschus and artificial Calculus Bovis are used alcohol dipping 2 hours, percolation is collected the liquid of filtering; add dissolved polyvinyl alcohol 50g and acetone, mixing adds 75% ethanol 1000ml; promptly get liniment, make every ml solution contain crude drug 1.186g.
Embodiment eight
Open * *, woman, 50 years old.Head examines day: on February 19th, 98.Neck pain is stiff, and disease of hand 2 years is surplus.The neck pain that started before 2 years is stiff not to relax, and increases the weight of gradually, shows pain unbearably, and more so pain caused and had difficulty in going to sleep night.And disease of hand is arranged, dizzy fear of cold, two just still can, stomach discomfort.Check: neck limitation of activity (+), the cervical vertebra tenderness (+++), pharyngeal congestion (+++), Hoffman ' s (±), the greasy in vain matter purple of tongue, stringy and thready pulse.Take each 12 of ball of stilbene Moschus moschiferous neck health (containing crude drug 16.7g), every day 3 times, totally 14 days, during on May 7th, 98 further consultation, pain was slow, but numbness of hand still has the thin fur thready pulse.Former method is come in and gone out, and continues to take each 12 of stilbene Moschus moschiferous neck health ball, and every day 3 times, totally 14 days, when examining, symptom was slow again.
Embodiment nine
King * *, man, 47 years old.First visit: on May 27th, 1998.The main suit: neck-shoulder pain 5 years, accompany right hemianesthesia, the right hand is unable, holds the thing shakiness, difficulty in walking.Check: pain behind the neck, cervical vertebra tenderness (++), neck limitation of activity (±), the experiment of brachial plexus tractive ((++), Hoffman ' s (±), 3 grades of RHGs, difficulty in walking, the loose stool frequent micturition is slept and rather lose night, has sore throat.MRI takes the photograph the sheet inspection and shows: the C5/6 annuler bulge, root compression is obvious.Greasy and thin fur, deep-thready pulse.Dialectical: cervical spondylotic radiculopathy.The rule of treatment: benefiting qi and removing blood stasis, dampness removing collateral dredging, antiinflammatory. pain relieving.Take 3 of sheets of stilbene Moschus moschiferous neck health (containing crude drug 16.7g), 3 times on the one, after totally 14 days, body pine limb is light, and the right hand is numb to be reduced.Recheck: right hand muscular strength is normal, and Hoffman ' sShi levies (one), cervical vertebra tenderness (+), pharyngeal hyperemia (±).Obey 3 of stilbene Moschus moschiferous neck health sheets again, 3 times on the one, after totally 14 days, all symptoms all slow and separate.
Embodiment ten
Shandong * *, woman, 55 years old.Head examines the date: on July 16th, 98.Neck is stiff not to relax, dizziness, headache, nose heave 7 years surplus.Two weeks of sx, neck is stiff do not relax start from 7 years before, and have the shoulder back of the body to pin down sense of discomfort.Two weeks came, and nose heave dizziness is dizzy, nausea, and heaviness of the head as being covered is wrapped up in generally, and limbs fatigue is stayed to receive to lose and is slept.Check: cervical vertebra tenderness (+), neck limitation of activity (±), Hoffman ' s (±), magnetic resonance examination prompting in 9 years: C3/4, C4/5 intervertebral disk hernia.Hyperosteogeny of cervical vertebra, tongue are greasy in vain, thready and hesitant pulse.Take stilbene Moschus moschiferous neck health-care composition 250ml (containing crude drug 50g), totally 14 days, two examined: on July 30th, 98, all illness alleviate, and nausea vomiting is healed, have a headache nose heavely to separate, have slight dizziness only, and patient's spirit also before has clear improvement.Per stilbene Moschus moschiferous neck health-care composition 250ml at taking medicine twice a day (containing crude drug 50g) totally 7 days.
Embodiment 11
Palace * *, man, 45 years old.Head examines day: on December 5th, 97.Neck pain is stiff, and disease of hand 5 years is surplus.The neck pain that starts is stiff not to relax, and increases the weight of gradually, and pain has difficulty in going to sleep unbearably, with disease of hand, and fear of cold, stomach discomfort.Check: neck limitation of activity (+) cervical vertebra tenderness (+), pharyngeal congestion (++), Hoffman ' s (+), the greasy in vain matter purple of tongue, stringy and thready pulse.Take 1 bag of stilbene Moschus moschiferous neck recovering particles (containing crude drug 16.7 g), every day 3 times, totally 14 days, during on January 7th, 98 further consultation, pain was slow, continues to take 1 bag of stilbene Moschus moschiferous neck recovering particles, every day 3 times, totally 14 days.When June 4 examined again in 98 year, symptom was slow.
Embodiment 12
Cao * *, man, 36 years old.First visit: on March 20th, 1997.Main suit: cervical part of esophagus decompression of spinal cord later six months.Cervicodynia is uncomfortable in chest, dizziness and fuzzy, difficulty in walking.Medical history: cervical vertebra medical history 4 years, the cervical vertebra decompression of spinal cord moves ahead half a year.Postoperative is still felt dizzy order paste, pillow back pain, and chest distress and palpitation symptoms, the constrained sense of body, limbs fatigue, difficulty in walking, the loose stool frequent micturition is slept and rather lose night, has sore throat.Check: instability of gait, muscular tension are not high, upper limb muscular strength 4+, and Hoffman ' sShi levies (+), cervical vertebra tenderness (++), pharyngeal hyperemia (++), pale red.MRI took the photograph the sheet inspection and showed in February, 97: C
2/3C
3/4C
5/6Annuler bulge, C
4/5Intervertebral disk hernia, compression of spinal cord is obvious.Greasy and thin fur, deep-thready pulse.Dialectical: the cervical spondylosis postoperative.The rule of treatment: benefiting qi and removing blood stasis, dampness removing collateral dredging, antiinflammatory. pain relieving.Take 3 of stilbene Moschus moschiferous neck recovering capsules (containing crude drug 16.7g), 3 times on the one, after totally 14 days, a wrong alleviation uncomfortable in chest, body pine limb is light, and two is just normal.Recheck: muscular strength is normal, and Hoffman ' sShi levies (-), cervical vertebra tenderness (+), pharyngeal hyperemia (±).Obey 3 of stilbene Moschus moschiferous neck recovering capsules again, 3 times on the one, after totally 14 days, all symptoms all slow and separate.
Claims (5)
1, a kind of compound Chinese medicinal preparation for the treatment of cervical spondylosis; it is characterized in that said preparation is all kinds of oral and external preparation, wherein active component is that the 30-47% Radix Astragali, 0.01-0.1% artificial Moschus, 17-20% Rhizoma Chuanxiong, 17-25% Caulis Sinomenii, 17-25% Radix Stephaniae Tetrandrae and 0.1-1.0% artificial Calculus Bovis make by percentage by weight.
2, a kind of compound Chinese medicinal preparation of treatment cervical spondylosis as claimed in claim 1 is characterized in that wherein said various oral and external preparation is pill, tablet, granule, mixture, capsule and external liniment.
3, a kind of compound Chinese medicinal preparation of treatment cervical spondylosis as claimed in claim 1 or 2 is characterized in that wherein said various oral and external preparation is matched by described active component prescription and a certain proportion of common medicinal supplementary material to form.
4, a kind of preparation method of compound Chinese medicinal preparation of treatment cervical spondylosis as claimed in claim 1 is characterized in that the preparation process of said preparation is as follows:
(1) preparation of active ingredient extractum
Rhizoma Chuanxiong, the Radix Astragali, Radix Stephaniae Tetrandrae, the Caulis Sinomenii of getting recipe quantity decoct with water twice, filter, and merging filtrate leaves standstill, and filter, and concentrating under reduced pressure promptly gets extractum;
(2) preparation of mixture
Get above-mentioned extractum, press recipe quantity and add artificial Moschus and artificial Calculus Bovis, water is adjusted to volume required, promptly gets mixture;
(3) preparation of pill, tablet, capsule
Get above-mentioned extractum, vacuum drying is ground into fine powder, presses recipe quantity and adds artificial Moschus's fine powder, artificial Calculus Bovis's fine powder, and mixing adds proper pharmaceutical excipients, crosses the 12-20 mesh sieve and gets the semi-finished product powder; The semi-finished product direct powder compression is promptly got tablet; The semi-finished product powder packed into promptly get capsule in the hungry area shell; The semi-finished product powder is granulated, and repressed method is made the ball coating and is promptly got pill;
(4) preparation of granule
Get above-mentioned extractum, add proper pharmaceutical excipients, make soft material, pushed the 12-20 mesh sieve with granulator and become granule, be drying to obtain:
(5) preparation of liniment
Press recipe quantity above-mentioned Rhizoma Chuanxiong, the Radix Astragali, Radix Stephaniae Tetrandrae, Caulis Sinomenii, artificial Moschus and artificial Calculus Bovis are used alcohol dipping 2 hours, percolation is collected the liquid of filtering, and adds dissolved polyvinyl alcohol 50g and acetone, and mixing adds a certain amount of 75% ethanol and promptly gets liniment.
5, the application of a kind of compound Chinese medicinal preparation as claimed in claim 1 in preparation treatment cervical spondylosis medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011265590A CN1177600C (en) | 2001-08-28 | 2001-08-28 | Chinese medicine compound preparation for treating cervical spondylosis, and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011265590A CN1177600C (en) | 2001-08-28 | 2001-08-28 | Chinese medicine compound preparation for treating cervical spondylosis, and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1401343A CN1401343A (en) | 2003-03-12 |
| CN1177600C true CN1177600C (en) | 2004-12-01 |
Family
ID=4666573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011265590A Expired - Lifetime CN1177600C (en) | 2001-08-28 | 2001-08-28 | Chinese medicine compound preparation for treating cervical spondylosis, and preparing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1177600C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198172B (en) * | 2011-05-26 | 2012-11-07 | 哈尔滨怡康药业有限公司 | Externally-applied powder for treating rheumatic arthralgia and preparation method thereof |
| WO2014201637A1 (en) * | 2013-06-19 | 2014-12-24 | 上海中医药大学附属龙华医院 | Compound preparation for treating cervical spondylosis with radiculopathy and preparation method therefor |
| CN112451592A (en) * | 2020-11-30 | 2021-03-09 | 北京航天情报与信息研究所 | Traditional Chinese medicine formula for improving lumbar spondylosis and preparation method |
| CN112451577A (en) * | 2020-11-30 | 2021-03-09 | 北京航天情报与信息研究所 | Traditional Chinese medicine formula for improving cervical spondylosis and preparation method |
-
2001
- 2001-08-28 CN CNB011265590A patent/CN1177600C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1401343A (en) | 2003-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101062194A (en) | Medicine for treating bone disease and fracture and the preparing method thereof | |
| CN101028376A (en) | Chinese medicinal preparation for treating habitual abortion | |
| CN1177600C (en) | Chinese medicine compound preparation for treating cervical spondylosis, and preparing process thereof | |
| CN1709314A (en) | Medicinal liquor for treating rheumatic arthrolithiasis and its preparing method | |
| CN1266704A (en) | Medicine for treating rheumatoid arthritis and preparing process thereof | |
| CN1824103A (en) | External use medicine for treating knocks and falls and bone joining | |
| CN100496542C (en) | Chinese traditional medicine composition for treating arthralgia syndrome of cervical spondylopathy and its preparation | |
| CN1895593A (en) | Medicine for treating acne and its preparation | |
| CN100402065C (en) | Capsule for treating gout and preparation process thereof | |
| CN1270744C (en) | Bone healthy pill used for treating protrasion of lumbar intervertebral disci | |
| CN1259970C (en) | Medication for treating discomfort caused by external wind and cold and preparation method | |
| CN1903354A (en) | Traditional Chinese medicine for treating lumbago and skelalgia | |
| CN102846699B (en) | Chinese medicinal composition for treating ischemic apoplexy and its preparation method | |
| CN102961662B (en) | Medicine for treating gastric ulcer and preparation method thereof | |
| CN114848716B (en) | Traditional Chinese medicine powder for treating kidney stones | |
| CN100444882C (en) | Capsules for zhongtongling for bone fracture and soft tissue injury and their making method | |
| CN101361882B (en) | Chinese medicine formulation for treating rheumatic osteoarthropathy | |
| CN1174768C (en) | Chinese medicine plaster for external application for curing hyperosteogeny, cervical spondylopathy and prolapse of lumbar intervertebral disk and its preparation method | |
| CN1074928C (en) | Medicine for curing hemiplegia and its preparing process | |
| CN1404850A (en) | Anti-inflammatory pain-releaving and swelling-diminishing external-use medicine | |
| CN1745802A (en) | Plaster for treating pain and prpearation thereof | |
| CN1069541C (en) | Medicine for treatment of cancer | |
| CN1209140C (en) | Chinese medicine for treating bony spur, cervical vertebra and lumber intervertebral disc protrasion | |
| CN104857458B (en) | A kind of Traditional Chinese medicine for decreasing blood sugar combination preparation and preparation method thereof | |
| CN100335112C (en) | Chinese medicine for treating kidney vacuity lumbar pain and preparation method of its capsule |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI HYUNDAI CHINASE MEDICAL TECHNOLOGY DEVEL Free format text: FORMER OWNER: SHANGHAI UNIV. OF TRADITIONAL CHINESE MEDICINE Effective date: 20030506 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20030506 Address after: 200051 days in Shanghai City Road No. 600 building 7F. Applicant after: Shanghai Sundise Address before: 200032 No. 530, Lingling Road, Shanghai Applicant before: Shanghai University of Traditional Chinese Medicine |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: SHANGHAI HUANGHAI PHARMACEUTICAL Co.,Ltd. Assignor: Shanghai Sundise Contract record no.: 2010990000482 Denomination of invention: Chinese medicine compound preparation for treating cervical spondylosis, and preparing process thereof Granted publication date: 20041201 License type: Exclusive License Open date: 20030312 Record date: 20100701 |
|
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI HUANGHAI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANGHAI MODERN TCM CO., LTD. Effective date: 20130425 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C56 | Change in the name or address of the patentee |
Owner name: SHANGHAI MODERN TCM CO., LTD. Free format text: FORMER NAME: SHANGHAI MODERN CHINESE TRADITIONAL MEDICINE TECHNOLOGY DEVELOPMENT CO., LTD. |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200050 CHANGNING, SHANGHAI TO: 200942 BAOSHAN, SHANGHAI |
|
| CP03 | Change of name, title or address |
Address after: 200050 Shanghai City Zhaofeng Plaza No. 1027 Changning District Changning Road, 33 floor Patentee after: Shanghai Sundise Chinese Medicine Technology Development Co.,Ltd. Address before: 200051 days in Shanghai City Road No. 600 building 7F. Patentee before: Shanghai Sundise |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130425 Address after: 200942 Shanghai City, Baoshan District Sheng Qiao Zhen Shi Tai Road No. 1288 Patentee after: SHANGHAI HUANGHAI PHARMACEUTICAL Co.,Ltd. Address before: 200050 Shanghai City Zhaofeng Plaza No. 1027 Changning District Changning Road, 33 floor Patentee before: Shanghai Sundise Chinese Medicine Technology Development Co.,Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20041201 |
|
| CX01 | Expiry of patent term |