CN104857458B - A kind of Traditional Chinese medicine for decreasing blood sugar combination preparation and preparation method thereof - Google Patents
A kind of Traditional Chinese medicine for decreasing blood sugar combination preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Traditional Chinese medicine for decreasing blood sugar combination preparations and preparation method thereof, belong to technical field of traditional Chinese medicines；The raw material group of Chinese medicine preparation active ingredient of the present invention becomes：Folium cortex eucommiae, annual fleabane herb, radix paeoniae rubra, Radix Astragali, Herba Lycopodii, Chinese coriaria leaf, kincup, Fructus Corni, radix scrophulariae, Radix Angelicae Sinensis, cordate houttuynia, curcuma zedoary；Chinese medicine preparation prescription of the present invention is reasonable, easy to use, good absorption effect, without bad and toxic side effect, according to clinical verification, can treat hyperglycemia and good effect, is suitable for hyperglycemia clinical treatment and is promoted and applied with nursing.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Traditional Chinese medicine for decreasing blood sugar combination preparation and preparation method thereof.
Background technology
With increasingly increasing for people's living standard, the daily life diet of people is more and more irregular, and various diseases are also wound
People.Especially mid-aged population, the people with hyperglycemia increase year by year, seriously endanger the physical and mental health of people.Glycosuria
Disease is that current people are difficult to one of disease broken through, and patient needs Long-term taking medicine and keeps on a diet, and diabetes model case is frequent
The performances, i.e. " three-many-one-little " symptom such as there are diuresis, more drink, eat more, become thin.Currently, the drug for the treatment of hyperglycemia mostly uses west
It cures and treats, the effect of these drug therapies is single, and doctor trained in Western medicine weak curative effect, side effect are big, and medical expense is high.
Invention content
The existing drug for treating hyperglycemia is found during daily medical diagnosis on disease, and there is drawbacks described above deficiency, this hairs
It is bright that the technical problem to be solved is that a kind of Traditional Chinese medicine for decreasing blood sugar combination preparations of offer and preparation method thereof；Chinese medicine preparation of the present invention
Prescription is reasonable, easy to use, good absorption effect, without bad and toxic side effect, according to clinical verification, can treat hyperglycemia and curative effect
It is good, it is suitable for hyperglycemia clinical treatment and is promoted and applied with nursing.
To achieve the above object, technical scheme of the present invention is implemented as follows.
A kind of Traditional Chinese medicine for decreasing blood sugar combination preparation and preparation method thereof, is made the raw material group of the Chinese medicine preparation active ingredient
At and parts by weight be：
6~12 parts of folium cortex eucommiae, 6~10 parts of annual fleabane herb, 8~12 parts of radix paeoniae rubra, 3~10 parts of Radix Astragali
6~8 portions of Herba Lycopodii, 3~6 portions of Chinese coriaria leaf, 5~10 portions of kincup, 4~9 parts of Fructus Corni
6~10 parts of radix scrophulariae, 3~6 parts of Radix Angelicae Sinensis, 4~8 parts of cordate houttuynia, 6~8 parts of curcuma zedoary.
The raw material that the Chinese medicine preparation active ingredient is made forms and parts by weight are：
6 parts of folium cortex eucommiae, 6 parts of annual fleabane herb, 8 parts of radix paeoniae rubra, 3 parts of Radix Astragali
6 portions of Herba Lycopodii, 3 portions of Chinese coriaria leaf, 5 portions of kincup, 4 parts of Fructus Corni
6 parts of radix scrophulariae, 3 parts of Radix Angelicae Sinensis, 4 parts of cordate houttuynia, 6 parts of curcuma zedoary.
The raw material that the Chinese medicine preparation active ingredient is made forms and parts by weight are：
8 parts of folium cortex eucommiae, 7 parts of annual fleabane herb, 9 parts of radix paeoniae rubra, 6 parts of Radix Astragali
7 portions of Herba Lycopodii, 5 portions of Chinese coriaria leaf, 8 portions of kincup, 7 parts of Fructus Corni
8 parts of radix scrophulariae, 4 parts of Radix Angelicae Sinensis, 6 parts of cordate houttuynia, 7 parts of curcuma zedoary.
The raw material that the Chinese medicine preparation active ingredient is made forms and parts by weight are：
12 parts of folium cortex eucommiae, 10 parts of annual fleabane herb, 12 parts of radix paeoniae rubra, 10 parts of Radix Astragali
8 portions of Herba Lycopodii, 6 portions of Chinese coriaria leaf, 10 portions of kincup, 9 parts of Fructus Corni
10 parts of radix scrophulariae, 6 parts of Radix Angelicae Sinensis, 8 parts of cordate houttuynia, 8 parts of curcuma zedoary.
A kind of preparation method of Traditional Chinese medicine for decreasing blood sugar combination preparation, comprises the following steps that：
（1）By folium cortex eucommiae, annual fleabane herb, radix paeoniae rubra, Radix Astragali, Herba Lycopodii, Chinese coriaria leaf, kincup, Fructus Corni, radix scrophulariae, Radix Angelicae Sinensis, cowherb
Art decontamination, is placed in container, and 5 ~ 10 times of distilled water is added and boils 1 ~ 2 hour, must extract after 60 DEG C extract 3 ~ 5 hours
Liquid, filtering, obtains filtrate, concentrates the filtrate to the medicinal extract that relative density is 1~1.3, is cooled to room temperature, ultraviolet radiation sterilizing,
It is spare；
（2）It takes cordate houttuynia decontamination, microwave drying to crush, crosses 80 mesh fine powders, extraction by steam distillation volatile oil is purple
UV radiation sterilizes, spare；
（3）By step（1）The medicinal extract of gained, with step（2）After the volatile oil of gained is sufficiently mixed, can add or
Pharmaceutically acceptable auxiliary material is not added（Disintegrant, adhesive etc.）Various dosage forms, such as powder, granule, mixture is made,
Traditional Chinese medicine for decreasing blood sugar combination preparation as of the present invention.
The pharmacological property of Chinese medicine used in the present invention is as follows.
Folium cortex eucommiae：Taste micro-pungent, it is warm-natured.Return liver and kidney channel.Filling liver kidney, strengthening the bones and muscles, blood pressure lowering.Main pain in back and loin；Sufficient knees soreness
It is weak；High blood pressure.There is the effects that hypoglycemic.
Annual fleabane herb：It is sweet in flavor, bitter, it is cool in nature.Return stomach；Large intestine channel.Help digestion antidiarrheal；It is clearing heat and detoxicating, there is the effects that hypoglycemic.
Radix paeoniae rubra：Bitter, cold nature.Return liver warp.Clearing heat and cooling blood, removing blood stasis and analgesics.There is the effects that reducing blood lipid and anti arteriosclerosis.
Radix Astragali：It is sweet in flavor, it is warm-natured.Return lung, the spleen channel.Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.It is weary for the deficiency of vital energy
Power, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, qi deficiency edema, ulcer is difficult to burst, burst for a long time and does not holds back, blood
Empty impotence is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes.
Herba Lycopodii：Mildly bitter flavor, it is cool in nature.Return liver warp.Wind-expelling pain-stopping；Relaxing tendons and activating collaterals.Main arthralgia pain due to rheumatism；Lumbar muscle strain.Have anti-
The effects that diabetes, antibacterial.
Chinese coriaria leaf：Acrid flavour, hardship, it is cold in nature.Distributed in heart and lung channels.It is clearing heat and detoxicating；Swelling and pain relieving.
Kincup：Acrid flavour, slight bitter, it is cool in nature.Returns spleen, lung channel.Wind dispelling；Relieving summer-heat；Activating blood circulation and reducing swelling.
Fructus Corni：It is sour, slightly warm in nature.Return liver and kidney channel.It tonifies the liver and kidney；Astringing and avoiding visceroptosis.Main waist is had a dizzy spell；Deafness and tinnitus；
Soreness and weakness of waist and knees；Xian essence involuntary emission；Frequent urination；Incessant sweating due to debility.There is the effects that hypoglycemic.
Radix scrophulariae：It is sweet in flavor, bitter, salty, cold nature.Return lung, stomach, kidney channel.Cool blood enriching yin, purging intense heat and detonicating.There are decompression, hypoglycemic etc.
Effect.
Radix Angelicae Sinensis：It is sweet in flavor, pungent, it is warm-natured.Return liver, the heart, the spleen channel.Replenishing and activating blood relaxes bowel.For blood deficiency chlorosis, the dizziness heart
Throb with fear, dry constipation of intestines, arthralgia pain due to rheumatism, ulcer sores.
Cordate houttuynia：Acrid flavour, cold nature.It is distributed in lung channel.It is clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.With good heat-clearing solution
The effects that malicious.
Curcuma zedoary：Acrid flavour, hardship, it is warm-natured.Return liver, the spleen channel.Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong.
Compared with prior art, the present invention having the advantages that：
（1）Medicinal material compatibility selected by Chinese medicine preparation of the present invention is suitable, meets traditional Chinese medicine and pharmacy and modern medical theory, each taste medicine
Material complements each other, notable to blood sugar decreasing effect, and securely and reliably, treating both manifestation and root cause of disease is worth clinically wide popularization and application；
（2）With the preparation method ratio of the prior art, preparation method of the present invention is simple, is suitble to industrialized production, extraction efficiency high.
Specific implementation mode
Present invention is further elaborated in following combination specific embodiment.
Embodiment 1.
The raw material of Chinese medicine preparation active ingredient of the present invention forms and parts by weight are：
6 parts of folium cortex eucommiae, 6 parts of annual fleabane herb, 8 parts of radix paeoniae rubra, 3 parts of Radix Astragali
6 portions of Herba Lycopodii, 3 portions of Chinese coriaria leaf, 5 portions of kincup, 4 parts of Fructus Corni
6 parts of radix scrophulariae, 3 parts of Radix Angelicae Sinensis, 4 parts of cordate houttuynia, 6 parts of curcuma zedoary.
The preparation method of Chinese traditional medicine composition preparation of the present invention, comprises the following steps that：
（1）By folium cortex eucommiae, annual fleabane herb, radix paeoniae rubra, Radix Astragali, Herba Lycopodii, Chinese coriaria leaf, kincup, Fructus Corni, radix scrophulariae, Radix Angelicae Sinensis, cowherb
Art decontamination, is placed in container, and 5 ~ 10 times of distilled water is added and boils 1 ~ 2 hour, must extract after 60 DEG C extract 3 ~ 5 hours
Liquid, filtering, obtains filtrate, concentrates the filtrate to the medicinal extract that relative density is 1~1.3, is cooled to room temperature, ultraviolet radiation sterilizing,
It is spare；
（2）It takes cordate houttuynia decontamination, microwave drying to crush, crosses 80 mesh fine powders, extraction by steam distillation volatile oil is purple
UV radiation sterilizes, spare；
（3）By step（1）The medicinal extract of gained, with step（2）After the volatile oil of gained is sufficiently mixed, can add or
Pharmaceutically acceptable auxiliary material is not added（Disintegrant, adhesive etc.）Various dosage forms, such as powder, granule, mixture is made,
Traditional Chinese medicine for decreasing blood sugar combination preparation as of the present invention.
Usage and dosage：Oral, 3 times a day, each primary in the morning, afternoon and evening, 2 tablets once, 20 days as a treatment course, usual 2 ~ 3 treatments
Cheng Youxiao, severe patient increase the amount of discretion.
Embodiment 2.
The raw material of Chinese medicine preparation active ingredient of the present invention forms and parts by weight are：
8 parts of folium cortex eucommiae, 7 parts of annual fleabane herb, 9 parts of radix paeoniae rubra, 6 parts of Radix Astragali
7 portions of Herba Lycopodii, 5 portions of Chinese coriaria leaf, 8 portions of kincup, 7 parts of Fructus Corni
8 parts of radix scrophulariae, 4 parts of Radix Angelicae Sinensis, 6 parts of cordate houttuynia, 7 parts of curcuma zedoary.
The Chinese medicine preparation preparation method processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 3.
The raw material of Chinese medicine preparation active ingredient of the present invention forms and parts by weight are：
12 parts of folium cortex eucommiae, 10 parts of annual fleabane herb, 12 parts of radix paeoniae rubra, 10 parts of Radix Astragali
8 portions of Herba Lycopodii, 6 portions of Chinese coriaria leaf, 10 portions of kincup, 9 parts of Fructus Corni
10 parts of radix scrophulariae, 6 parts of Radix Angelicae Sinensis, 8 parts of cordate houttuynia, 8 parts of curcuma zedoary.
The Chinese medicine preparation preparation method processing step and usage and dosage of the present embodiment are same as Example 1.
Clinical data.
1, case selection：
The case 100 for meeting hyperglycemia diagnostic criteria is chosen altogether.
2, medicament selection：
Treatment group patient takes Chinese medicine preparation of the present invention, takes orally, and 3 times a day, each primary in the morning, afternoon and evening, 2 tablets once, is within 20 days
One course for the treatment of, takes 2 course for the treatment of.
3, efficacy determination：
（1）Recovery from illness, fasting blood-glucose and postprandial 2 hours blood glucose drop to normal range (NR) or fasting blood-glucose and 2 hours postprandial
Blood glucose value decrease beyond 50% before treatment, and glycosylated hemoglobin value drops to normally；
（2）Effective, fasting blood-glucose and postprandial 2 hours blood glucose drop to normal range (NR) or fasting blood-glucose and 2 hours postprandial
Blood glucose value decrease beyond treatment before 40%, glycosylated hemoglobin value drops to normally, or decrease beyond treat before 30%.；
（3）Effectively, fasting blood-glucose and postprandial 2 hours sugar decrease beyond 20% before treatment, but not up to effective standard,
Glycosylated hemoglobin value decrease beyond 10% before treatment, but not up to effective standard；
（4）In vain, tcm clinical practice symptom, sign are not improved, even aggravating, disease integration is reduced less than 30%；
Fasting blood-glucose and postprandial 2 hours blood glucose are without decline, or decline and be not up to effective standard, glycosylated hemoglobin value without decline, or under
Drop is not up to effective standard.
4, result：
As a result：In 100 patients, invalid 5, effective 15, effective 50, fully recover 30.Total effective rate is 95%,
Cure rate is 30%.
Claims (4)
1. a kind of Traditional Chinese medicine for decreasing blood sugar combination preparation, it is characterised in that：The raw material composition of the Chinese medicine preparation active ingredient is made
And parts by weight are：
6~12 parts of folium cortex eucommiae, 6~10 parts of annual fleabane herb, 8~12 parts of radix paeoniae rubra, 3~10 parts of Radix Astragali
6~8 portions of Herba Lycopodii, 3~6 portions of Chinese coriaria leaf, 5~10 portions of kincup, 4~9 parts of Fructus Corni
6~10 parts of radix scrophulariae, 3~6 parts of Radix Angelicae Sinensis, 4~8 parts of cordate houttuynia, 6~8 parts of curcuma zedoary.
2. according to a kind of Traditional Chinese medicine for decreasing blood sugar combination preparation described in claim 1, it is characterised in that：The Chinese medicine system is made
The raw material of agent active ingredient forms and parts by weight are：
6 parts of folium cortex eucommiae, 6 parts of annual fleabane herb, 8 parts of radix paeoniae rubra, 3 parts of Radix Astragali
6 portions of Herba Lycopodii, 3 portions of Chinese coriaria leaf, 5 portions of kincup, 4 parts of Fructus Corni
6 parts of radix scrophulariae, 3 parts of Radix Angelicae Sinensis, 4 parts of cordate houttuynia, 6 parts of curcuma zedoary.
3. according to a kind of Traditional Chinese medicine for decreasing blood sugar combination preparation described in claim 1, it is characterised in that：The Chinese medicine system is made
The raw material of agent active ingredient forms and parts by weight are：
8 parts of folium cortex eucommiae, 7 parts of annual fleabane herb, 9 parts of radix paeoniae rubra, 6 parts of Radix Astragali
7 portions of Herba Lycopodii, 5 portions of Chinese coriaria leaf, 8 portions of kincup, 7 parts of Fructus Corni
8 parts of radix scrophulariae, 4 parts of Radix Angelicae Sinensis, 6 parts of cordate houttuynia, 7 parts of curcuma zedoary.
4. according to a kind of Traditional Chinese medicine for decreasing blood sugar combination preparation described in claim 1, it is characterised in that：The Chinese medicine system is made
The raw material of agent active ingredient forms and parts by weight are：
12 parts of folium cortex eucommiae, 10 parts of annual fleabane herb, 12 parts of radix paeoniae rubra, 10 parts of Radix Astragali
8 portions of Herba Lycopodii, 6 portions of Chinese coriaria leaf, 10 portions of kincup, 9 parts of Fructus Corni
10 parts of radix scrophulariae, 6 parts of Radix Angelicae Sinensis, 8 parts of cordate houttuynia, 8 parts of curcuma zedoary.
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Effective date of registration: 20210624 Address after: 222000 No.14, Yuntai Road, Lianyun old street, Lianyun District, Lianyungang City, Jiangsu Province Patentee after: Jiangsu Lianyungang dandelion Institute of traditional Chinese Medicine Address before: No.716, 7th floor, building 4, No.99 Guangfu Road, Wuhou District, Chengdu, Sichuan 610000 Patentee before: Chengdu yishenrui Technology Co.,Ltd. Effective date of registration: 20210624 Address after: No.716, 7th floor, building 4, No.99 Guangfu Road, Wuhou District, Chengdu, Sichuan 610000 Patentee after: Chengdu yishenrui Technology Co.,Ltd. Address before: 416000 science and Technology Office of Jishou University, 120 Renmin South Road, Jishou City, Xiangxi Tujia and Miao Autonomous Prefecture, Hunan Province Patentee before: JISHOU University |