CN101062194A - Medicine for treating bone disease and fracture and the preparing method thereof - Google Patents

Medicine for treating bone disease and fracture and the preparing method thereof Download PDF

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CN101062194A
CN101062194A CNA200710054480XA CN200710054480A CN101062194A CN 101062194 A CN101062194 A CN 101062194A CN A200710054480X A CNA200710054480X A CN A200710054480XA CN 200710054480 A CN200710054480 A CN 200710054480A CN 101062194 A CN101062194 A CN 101062194A
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fracture
medicine
radix
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CN101062194B (en
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刘建华
刘果
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Abstract

The invention relates to a pharmaceutical composition for treating osteonosus and bone fracture and process for preparation, wherein the raw materials include achyranthes and cyathula root, native copper, drynaria, frankincense, myrrh, ledebouriella root, buck grass, wood louse, cortex acanthopanacis and root bark of chinese wolf berry. The medicament can be prepared into various dosage forms including electuary, ointment, sprays and lotions.

Description

The medicine and the preparation method of treatment osteopathia, fracture
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of medicine and preparation method for the treatment of osteopathia, fracture.
Background technology
In the daily life owing to reasons such as unexpected injury or daily behavior be improper cause the sick and wounded of human body a part easily,, traumatic injury outstanding, lumbar muscle strain, wind and cold lumbago and skelalgia, hyperosteogeny etc. as the awl intercalated disc, serious also have fracture.At present the medicine of outstanding, the traumatic injury of treatment awl intercalated disc, lumbar muscle strain, wind and cold lumbago and skelalgia, hyperosteogeny is a lot, have oral and external used medicine, general medicine for external use mostly is in the affected part and applies plaster, smears medicated wine greatly and maybe will verify and be applied to sore spot after Chinese herbal medicine is smashed to pieces, and its anti-inflammatory analgetic is undesirable.And the method for treatment fracture at present is mainly Chinese traditional treatment and western medical treatment, its integrative therapy fracture adopts para-position to wrap up, clamping plate or plaster fixation are hindered position or operative treatment, but the operative treatment complexity is big to patient's wound, and cost is high, the wrapping para-position is fixed, full treatment time is long by self-sow, all brings very big misery for patient's the human body and psychology.Many shortages can obviously promote the medicine of union of fracture in the above-mentioned employed method.
Summary of the invention
The purpose of invention provides a kind of good analgesic effect, can promote callus formation, the treatment osteopathia that shortens the course of treatment, the medicine of fracture.
The present invention realizes above-mentioned purpose by the following technical solutions: a kind of medicine for the treatment of osteopathia, fracture, mainly make by the raw material of following parts by weight:
Radix Ilicis Cornutae 20~80 Radix Cyathulaes 18~28 Pyritums 18~28 Rhizoma Drynariae 18~28
Olibanum 18~28 Myrrhas 18~28 Radix Saposhnikoviaes 18~28 Herba Lycopodiis 18~28
Eupolyphaga Seu Steleophaga 18~28 Cortex Acanthopanacis Radicis 20~35 Cortex Lycii 20~35
The medicine of treatment osteopathia, fracture also comprises the raw material of following parts by weight:
Sanguis Draxonis 18~28 Radix Rehmanniae 18~28 Ramulus Cinnamomi 18~28 Rhizoma Homalomenaes 18~28 Herba Wedeliae Wallichii 18~28
The medicine of treatment osteopathia, fracture is preferably made by the raw material of following parts by weight:
Radix Ilicis Cornutae 40~60 Radix Cyathulaes 20~25 Pyritums 20~25 Rhizoma Drynariae 20~25
Olibanum 18~22 Myrrhas 20~25 Radix Saposhnikoviaes 20~25 Herba Lycopodiis 23~28
Eupolyphaga Seu Steleophaga 18~22 Cortex Acanthopanciss 28~32 Cortex Lycii 28`32 Sanguis Draxonis 20~25
Radix Rehmanniae 18~22 Ramulus Cinnamomi 20~25 Rhizoma Homalomenaes 20~25 Herba Wedeliae Wallichii 20~25
The medicine of treatment osteopathia, fracture is most preferably made by the raw material of following parts by weight:
Radix Ilicis Cornutae 55 Radix Cyathulaes 23 Pyritums 23 Rhizoma Drynariae 23
Olibanum 20 Myrrhas 23 Radix Saposhnikoviaes 23 Herba Lycopodiis 25
Eupolyphaga Seu Steleophaga 20 Cortex Acanthopanciss 30 Cortex Lycii 30 Sanguis Draxonis 23
Radix Rehmanniae 18 Ramulus Cinnamomi 23 Rhizoma Homalomenaes 23 Herba Wedeliae Wallichii 23
The raw material of above-mentioned treatment osteopathia, fracture adds adjuvant can be prepared into the various clinical pharmaceutical dosage form according to conventional method, comprises any in emplastrum, ointment, spray, the lotion.
The preparation method of the medicinal plaster agent of treatment osteopathia, fracture: crude drug is pulverized, Oleum sesami with the 2000-2500 parts by weight soaks, slow fire frying then, withered black to medicine, remove slag, continue refining again to dripping into pearl, the oil that refining is good is from fire, add the Plumbum preparatium of 700-1500 parts by weight, be stirred to the dense smoke of emerging, treat that flue gas is most slightly and drip into pearl, continue to stir that to be cooled to ointment warm, the stand is applied on the plaster base material and gets final product.
The preparation method of the medicinal plaster agent of treatment osteopathia, fracture is preferred: crude drug is pulverized, Oleum sesami with 2300 parts by weight soaks, slow fire frying then, withered black to medicine, remove slag, continue refining again to dripping into pearl, the oil that refining is good is from fire, add the Plumbum preparatium of 900 parts by weight, be stirred to the dense smoke of emerging, treat that flue gas is most slightly and drip into pearl, continue to stir that to be cooled to ointment warm, the stand is applied on the plaster base material and gets final product.
Oleum sesami soaks the time of crude drug: four days springs, three days summers, five days autumns, seven days winters.
The present invention treats fracture, osteopathia, but both blood circulation promoting, the quick silt were loose, and reducing swelling and alleviating pain can impel growth of spur again, healing rate height, treating both the principal and secondary aspects of a disease for fracture.This medicine not only has significant curative effect, and pertinacious diseases such as osteoarthritis, rheumatoid arthritis, cervical spondylosis, lumbago and skelalgia is had better curative effect fracture, soft tissue strain and contusion.In medicine material, Radix Ilicis Cornutae is bitter cool, promoting blood circulation to remove obstruction in the collateral, and the wind dehumidifying of loosing, reunion of fractured tendons and bones, cooling blood and relieving pain is used for rheumatic arthritis, lumbar muscle strain; Olibanum is arduous, and temperature is gone into the conscience spleen channel, transfers the blood wind of invigorating blood circulation, and analgesic therapy chases after poison, does not have flavour of a drug bitter flat, goes into Liver Channel, and diffusing blood goes to become silted up subduing swelling and relieving pain; The bitter temperature of Rhizoma Drynariae is gone into the Liver and kidney warp, and the kidney invigorating is invigorated blood circulation, hemostasis; Sanguis Draxonis is sweet salty, and is flat, goes into the conscience warp, the silt analgesic therapy of loosing, hemostasia and promoting granulation; The sweet temperature of Herba Wedeliae Wallichii is enriched blood and is invigorated blood circulation; The Radix Saposhnikoviae suffering is sweet, and temperature is gone into bladder, and the lung spleen channel is delivered, and dispels the wind, and wins and wets, pain relieving; The Herba Lycopodii toil, temperature is gone into liver spleen kidney three warps, expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation; The Radix Rehmanniae promote the production of body fluid and heat-removing, removing heat from blood, hemostasis; The hot liver of Ramulus Cinnamomi, temperature is gone into bladder, cardiopulmonary warp, diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation; Pyritum is arduous, and is flat, goes into kidney meridian, liver channel of foot-Jueyin, the silt pain relieving of loosing, reunion of bone; The hot temperature of Rhizoma Homalomenae is gone into liver lung two warps, wind-damp dispelling, strengthening bone and muscle, pain relieving, detumescence; The acid of Radix Achyranthis Bidentatae sweetness and bitterness, flat, go into the Liver and kidney warp, the congestion that looses, subduing inflammation; Eupolyphaga Seu Steleophaga is salty-cold. go into Liver Channel. and removing blood stasis is logical to become silted up reunion of fractured tendons and bones; The arduous temperature of Cortex Acanthopancis. go into the Liver and kidney warp. wind-damp dispelling, bone and muscle strengthening; Cortex Lycii is sweet light cold. go into the lung kidney channel. and removing heat from blood moves back steaming, and is antibiotic.The present invention adopts pure raw material of Chinese medicine, forms through the science composition of prescription, have promoting blood circulation to remove blood stasis, promoting the flow of QI in the collateral by warming the meridian, Shujin eliminating stagnation, the tissue regeneration promoting that nourishes blood, regulate the flow of vital energy, effect such as circulation of qi promoting, pain relieving, and have evident in efficacy, instant effect, have no side effect, advantage such as taking convenience.
The specific embodiment
The present invention enumerates 9 embodiment, and the parts by weight of each embodiment component see the following form:
Embodiment 1 ?2 ?3 ?4 ?5 ?6 ?7 ?8 ?9
Radix Ilicis Cornutae 20 ?40 ?36 ?50 ?60 ?25 ?55 ?65 ?40
Radix Cyathulae 25 ?18 ?20 ?28 ?22 ?28 ?23 ?19 ?24
Pyritum 18 ?25 ?20 ?26 ?27 ?19 ?23 ?22 ?23
Rhizoma Drynariae 28 ?26 ?25 ?20 ?19 ?23 ?22 ?26 ?23
Olibanum 22 ?18 ?28 ?25 ?26 ?22 ?23 ?20 ?21
Myrrha 19 ?20 ?25 ?28 ?25 ?20 ?19 ?23 ?22
Radix Saposhnikoviae 26 ?20 ?23 ?25 ?26 ?28 ?18 ?19 ?21
Herba Lycopodii 25 ?22 ?20 ?18 ?26 ?28 ?27 ?22 ?24
Eupolyphaga Seu Steleophaga 20 ?18 ?28 ?22 ?26 ?25 ?19 ?23 ?27
Cortex Acanthopancis 35 ?30 ?20 ?30 ?28 ?34 ?32 ?33 ?25
Cortex Lycii 30 ?25 ?29 ?30 ?35 ?28 ?31 ?22 ?26
Sanguis Draxonis 18 ?25 ?20 ?22 ?28 ?23
Radix Rehmanniae 22 ?18 ?25 ?28 ?23 ?18
Ramulus Cinnamomi 23 ?25 ?20 ?18 ?28 ?26
Rhizoma Homalomenae 28 ?18 ?20 ?25 ?23 ?26
Herba Wedeliae Wallichii 25 ?23 ?20 ?18 ?28 ?22
Emplastrum preparation: above-mentioned raw materials medicated powder is broken, Oleum sesami with 2300 parts by weight soaks, slow fire frying then, withered black to medicine, remove slag, continue refining again to dripping into pearl, the oil that refining is good is from fire, add the Plumbum preparatium of 900 parts by weight, be stirred to the dense smoke of emerging, treat that flue gas is most slightly and drip into pearl, continue to stir that to be cooled to ointment warm, the stand is applied on the plaster base material and gets final product.
Concrete case:
1, retired cadre Lee of Queshan County supply and marketing cooperative * * man 75 years old, he in December in 2005 traumatic injury on the 29th, the X sheet shows left side femoral shaft screw type fracture, pain unbearably, diabetic history there are 23 years, by giving its expectant treatment affected part Dressed plaster alleviating pain symptom on the five, after 6 courses of treatment, check X-ray sheet shows that callus generates, can hold up turn and stand, can normally walk after 4 months, not have tenderness apart from the follow-up observation affected part, walking is normal, and life can take care of oneself.
2, Yuan Zhuan village, Pu Huisi township height * 32 years old hyperosteogeny of cervical vertebra of man, it is straight that curvature becomes, the course of disease 2 years more than, the pain of can not working unbearably, restriction of neck motion, one side upper limb nerve symptom is obvious, in that not go out therapeutic effect not good enough, the plaster of the invention that loses money in a business is after 4 weeks, and nervous symptoms disappears, pain relief can be worked.
3, Zhao * man is 11 years old, old * * man 15 years old, open * man 22 years old etc., all be in school or when playing outside traumatic injury respectively ulna, scratch the bone fracture, the plaster treatment of the invention that loses money in a business, remission in five days, promptly there was callus formation in three weeks.
4, Pu Huisi township retired cadre open * * man 69 years old after traumatic injury in January, 2004, the X sheet show the left side Patella fracture, history of hypertension is arranged, by three days clinical symptom reliefs of affected part external application plaster of the present invention, look into the X sheet all around and show that callus generates, the walking of leaving the bed in six weeks, life can take care of oneself.
5, Pingyu County Lee * * man 73 years old bilateral knee joint degenerative diseases of aged, lumbago and skelalgia 6 years, pain unbearably, can't take care of oneself, moving obstacle behind the joint is sought in many ways curing to treat not have and is taken a turn for the better, invention plaster pain relief after January loses money in a business, the joint can be suitably movable, and after three months, the joint flexing reaches 75 degree, the energy out-of-bed activity, after following up a case by regular visits to 2 years, joint motion is normal, and life can take care of oneself.
6, pacify * * women 63 years old, suffer from intervertebral disk hernia, with rheumatic arthritis, the course of disease 6 years more than, can not work, behind the pressuring neural root, a nervus lateralis symptom bilateral arthralgia occur, long-term oral analgesic and hormone, through multi-treatment, DeGrain, after lose money in a business the invention plaster after January, nervous symptoms is alleviated, and flank pain and arthralgia alleviate.
7, prunus mume (sieb.) sieb.et zucc. * * man's drunk back traumatic injury in 20 years old, be diagnosed as soft tissue injury after the inspection, the pain cyanosis of the skin is pasted the back recovery from illness with plaster 1 of the present invention.
The case statistics:
(1) case is selected: select case 47 examples, and wherein incomplete fracture 13 examples, complete fracture 8 examples, comminuted bone 3 examples, soft tissue injury 11 examples, hyperosteogeny 3 examples, lumbago and skelalgia 5 people, arthritis 4 people, wherein male 26 people, women 21 people, the age is 8~75 years old.
(2) medication:
Illing skin is cleaned up, with plaster with low baking temperature roasting after, tear and paste the affected part, pasting the coating skin scratches where it itches if having slightly, available hands is pinned plaster and is massaged gently, can eliminate if paste the medicine place scratch where it itches obviously irritated, can oral antiallergic agent or plaster taken off get final product, an obedient plaster can use 7 days (7 days is a course of treatment).
(3) Gu Zhe curative effect determinate standard:
1, incomplete fracture
Clinical healing: sx in the medication 5 days, 12 days internal callus maturations, union of fracture and sign disappear.
Produce effects: sx in the medication 8 days, 15 days internal callus maturations, most of sign disappears.
Effectively: sx in the medication 8 days, part sign Xiao loses.
Invalid: medication can not or alleviate clinical symptoms in 12 days and sign disappears.
2, complete fracture
Clinical healing: sx in the medication 15 days, callus formation, 20 days internal callus maturations.
Produce effects: sx in the medication 15 days, 20 days internal callus maturations, most of sign disappears.
Effectively: sx in the medication 15 days, the part sign disappears.
Invalid: medication can not or alleviate clinical symptoms in 3 weeks and sign disappears.
3, comminuted fracture
Clinical healing: after 4 weeks of medication, sx, union of fracture is shaped.
Produce effects: after 4 weeks of medication, big of symptom alleviates entirely, and fracture healing slightly late forms.
Effectively: after 4 weeks of medication, symptom partly alleviates, 5~6 just healing shapings of week back fracture.
Invalid: clinical symptoms does not have and alleviates or alleviate slightly, nonunion after the medication.
(4) therapeutic effect statistical table:
Name of disease Clinical cure Produce effects Effectively Invalid
Incomplete fracture 13 ?0 ?0 ?0
Complete fracture 8 ?0 ?0 ?0
Comminuted fracture 2 ?1 ?0 ?0
The damage of soft tissue pine 11 ?0 ?0 ?0
Hyperosteogeny 1 ?2 ?0 ?0
Lumbago and skelalgia 0 ?4 ?1 ?0
Arthritis 0 ?1 ?3 ?0
From last table: the total effective rate of treatment acute soft tissue injury is 100%; The total effective rate 68.06% of treatment rheumatoid arthritis; Treatment incomplete fracture total effective rate is 100%; The total effective rate 100% of treatment complete fracture, treatment comminuted fracture total effective rate is 100%.According to the healing time classification of different fracture sites, healing case situation is as follows:
Figure A20071005448000091
Tibia and fracture of fibula 2 ?3
Find out the difference course of treatment for miscellaneous fracture from last table: four to five weeks of clavicular fracture can cure; Two to three weeks of fracture of rib can cure; Four to six weeks of humeral fracture can cure; Chi is scratched the bone fracture and can be cured in three to five weeks; Fracture of phalanges three is to curing all around; Six to eight weeks of fracture of femoral neck can cure; Five to seven weeks of fracture of shaft of femur can cure; Four to five weeks of Patella fracture can cure; Tibia and four to five weeks of fibula can cure.On the time of curing, break said saying injured in the sinews or bones 100 days among the people, thereby alleviated patient's misery, improved the time of movable exercise, reduced the incidence rate of joint function disturbance.(because of the speed of age and individual difference healing also can be different).

Claims (7)

1, a kind of medicine for the treatment of osteopathia, fracture is characterized in that, is mainly made by the raw material of following parts by weight:
Radix Ilicis Cornutae 20~80 Radix Cyathulaes 18~28 Pyritums 18~28 Rhizoma Drynariae 18~28
Olibanum 18~28 Myrrhas 18~28 Radix Saposhnikoviaes 18~28 Herba Lycopodiis 18~28
Eupolyphaga Seu Steleophaga 18~28 Cortex Acanthopanciss 20~35 Cortex Lycii 20~35
2, the medicine of treatment osteopathia as claimed in claim 1, fracture is characterized in that, also comprises the raw material of following parts by weight:
Sanguis Draxonis 18~28 Radix Rehmanniae 18~28 Ramulus Cinnamomi 18~28 Rhizoma Homalomenaes 18~28 Herba Wedeliae Wallichii 18~28.
3, the medicine of treatment osteopathia as claimed in claim 2, fracture is characterized in that, is made by the raw material of following parts by weight:
Radix Ilicis Cornutae 40~60 Radix Cyathulaes 20~25 Pyritums 20~25 Rhizoma Drynariae 20~25
Olibanum 18~22 Myrrhas 20~25 Radix Saposhnikoviaes 20~25 Herba Lycopodiis 23~28
Eupolyphaga Seu Steleophaga 18~22 Cortex Acanthopanciss 28~32 Cortex Lycii 28`32 Sanguis Draxonis 20~25
Radix Rehmanniae 18~22 Ramulus Cinnamomi 20~25 Rhizoma Homalomenaes 20~25 Herba Wedeliae Wallichii 20~25.
4, the medicine of treatment osteopathia as claimed in claim 3, fracture is characterized in that, is made by the raw material of following parts by weight:
Radix Ilicis Cornutae 55 Radix Cyathulaes 23 Pyritums 23 Rhizoma Drynariae 23
Olibanum 20 Myrrhas 23 Radix Saposhnikoviaes 23 Herba Lycopodiis 25
Eupolyphaga Seu Steleophaga 20 Cortex Acanthopanciss 30 Cortex Lycii 30 Sanguis Draxonis 23
Radix Rehmanniae 18 Ramulus Cinnamomi 23 Rhizoma Homalomenaes 23 Herba Wedeliae Wallichii 23.
As the medicine of any described treatment osteopathia of claim 1~4, fracture, it is characterized in that 5, raw material adds adjuvant can be prepared into the various clinical pharmaceutical dosage form, comprise any in emplastrum, ointment, spray, the lotion.
6, the preparation method of the medicinal plaster agent of treatment osteopathia, fracture is characterized in that, crude drug is pulverized, Oleum sesami with the 2000-2500 parts by weight soaks, slow fire frying then, withered black to medicine, remove slag, continue refining again to dripping into pearl, the oil that refining is good is from fire, add the Plumbum preparatium of 700-1500 parts by weight, be stirred to the dense smoke of emerging, treat that flue gas is most slightly and drip into pearl, continue to stir that to be cooled to ointment warm, the stand is applied on the plaster base material and gets final product.
7, the preparation method of the medicinal plaster agent of treatment osteopathia as claimed in claim 6, fracture is characterized in that, crude drug is pulverized, Oleum sesami with 2300 parts by weight soaks, slow fire frying then, withered black to medicine, remove slag, continue refining again to dripping into pearl, the oil that refining is good is from fire, add the Plumbum preparatium of 900 parts by weight, be stirred to the dense smoke of emerging, treat that flue gas is most slightly and drip into pearl, continue to stir that to be cooled to ointment warm, the stand is applied on the plaster base material and gets final product.
CN200710054480XA 2007-06-01 2007-06-01 Medicine for treating bone disease and fracture and the preparing method thereof Expired - Fee Related CN101062194B (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102824554A (en) * 2012-08-27 2012-12-19 单淑香 Method of preparing traditional Chinese medicine lotion for treating thirsty-type closed fracture
CN103989815A (en) * 2014-04-21 2014-08-20 史家举 Externally used traditional Chinese medicine for treating rheumatoid arthritis
CN104225413A (en) * 2014-10-23 2014-12-24 张相才 Orthopedic patch for external application and preparation method thereof
CN104524483A (en) * 2015-02-02 2015-04-22 范晓华 Tincture for promoting bone injury healing and preparation method thereof
CN105381082A (en) * 2015-12-03 2016-03-09 梅亦民 Drug for treating bone diseases and preparation method thereof
CN106492022A (en) * 2016-11-25 2017-03-15 安徽珂欣茧业有限公司 A kind of bone-knitting Chinese medicament formula handed down from one's ancestors and preparation method thereof
CN109125676A (en) * 2018-11-07 2019-01-04 李辉青 For the Chinese medicine composition of bone disease treatment, bone setting powder and its preparation method and application
CN109846925A (en) * 2019-02-19 2019-06-07 崇州蜀州颈腰病医院有限公司 The cold side of washing of medicinal powder used for clearing stagnation-syndrome of " qi " and blood and its application

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102824554A (en) * 2012-08-27 2012-12-19 单淑香 Method of preparing traditional Chinese medicine lotion for treating thirsty-type closed fracture
CN102824554B (en) * 2012-08-27 2013-11-06 王慧 Method of preparing traditional Chinese medicine lotion for treating thirsty-type closed fracture
CN103989815A (en) * 2014-04-21 2014-08-20 史家举 Externally used traditional Chinese medicine for treating rheumatoid arthritis
CN104225413A (en) * 2014-10-23 2014-12-24 张相才 Orthopedic patch for external application and preparation method thereof
CN104524483A (en) * 2015-02-02 2015-04-22 范晓华 Tincture for promoting bone injury healing and preparation method thereof
CN105381082A (en) * 2015-12-03 2016-03-09 梅亦民 Drug for treating bone diseases and preparation method thereof
CN106492022A (en) * 2016-11-25 2017-03-15 安徽珂欣茧业有限公司 A kind of bone-knitting Chinese medicament formula handed down from one's ancestors and preparation method thereof
CN109125676A (en) * 2018-11-07 2019-01-04 李辉青 For the Chinese medicine composition of bone disease treatment, bone setting powder and its preparation method and application
CN109846925A (en) * 2019-02-19 2019-06-07 崇州蜀州颈腰病医院有限公司 The cold side of washing of medicinal powder used for clearing stagnation-syndrome of " qi " and blood and its application

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