CN101987180B - Medicine for treating dermatitis medicamentosa and preparation method thereof - Google Patents
Medicine for treating dermatitis medicamentosa and preparation method thereof Download PDFInfo
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- CN101987180B CN101987180B CN201010264930XA CN201010264930A CN101987180B CN 101987180 B CN101987180 B CN 101987180B CN 201010264930X A CN201010264930X A CN 201010264930XA CN 201010264930 A CN201010264930 A CN 201010264930A CN 101987180 B CN101987180 B CN 101987180B
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Abstract
The invention discloses a medicine for treating dermatitis medicamentosa, which is characterized by mainly comprising the following raw materials in parts by weight: 1-20 parts of rose, 1-20 parts of seville orange flower, 1-20 parts of Radix Rehmanniae, 1-20 parts of Cortex moutan, 1-20 parts of root of common peony, 1-20 parts of rhizoma anemarrhenae, 1-20 parts of honeysuckle, 1-20 parts of fructus forsythia, 1-20 parts of bamboo leaf, 1-20 parts of gypsum, 1-20 parts of raw liquorice and 1-20 parts of edible alcohol with concentration more than 95 percent. The medicine not only can be taken orally to be absorbed by the spleen and the stomach, but also can be externally used to be absorbed by skins and can also be taken orally and externally used to be compositely absorbed. The medicine has reasonable formula, simple compatibility and exact curative effect and treats both principal and secondary aspects of diseases. The invention also provides a preparation method for the medicine.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the medicine dermatitis of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Drug eruption is called for short drug eruption, is that approach such as medicine administered through oral, external and injection get into human body and the reaction of the mucocutaneous inflammation that causes.Symptom is various, and performance is complicated, but all arranged certain incubation period.The characteristics of its erythra are that normal generation suddenly except that fixed eruptions, seldom has characteristic, and mostly the erythra distribution is general, popularity, symmetry.Drug eruption is very big to the harm of human body.Nearly all medicine all might cause dermatitis.
This type drug eruption is clinical mainly to show as erythema, pimple, phlysis, ooze out, rotten to the corn, incrustation property erythra.It can be divided into limitation and general property amphitypy; Mostly topical type is drug-induced light allergic rash, therefore mainly occurs in the sunlight exposure position, and the lichenization erythra takes place.The general hair style of whole body can have low grade fever, pruritus, and the serious pustular erythra that foxtail millet grain to grain of rice size also can be arranged is mixed wherein.Often there is one deck bran shape squama to come off after disappearing.
One Chinese patent application CN200810108946.4 discloses a kind of Chinese medicine preparation, promptly a kind of Chinese medicine for oral administration of treating blood-heat drug induced dermatitis.Its medicine is the decoction of being processed by the raw material of following weight parts: Fructus Hyperici belli 20-24 gram, Radix Puerariae, each 13-15 gram of Radix Isatidis, Cornu Bubali, each 7-8 gram of Folium Averrhoae Carambolae.
The Chinese medicine product of above-mentioned medicine dermatitis is too much paid attention to regulating, and has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to the decoction or the pill that are mostly to boil than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists; A kind of reasonable recipe is provided; Compatibility is simplified, the medicine of the medicine dermatitis of determined curative effect, treating both the principal and secondary aspects of a disease, is main to control, and controls to support to combine; And this medicine can take orally through taste absorb again can external through skin absorbs, can also oral administration and externally used dual mode composite absorbent.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is following:
A kind of medicine of medicine dermatitis is characterized in that it mainly is to be processed by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of Citrus aurantium L. var. amara Engl.; 1 ~ 20 part in the Radix Rehmanniae, 1 ~ 20 part of Cortex Moutan, 1 ~ 20 part of Radix Paeoniae Rubra; 1 ~ 20 part of the Rhizoma Anemarrhenae, 1 ~ 20 part of Flos Lonicerae, 1 ~ 20 part of Fructus Forsythiae; 1 ~ 20 part on Folium Bambusae, 1 ~ 20 part of Gypsum Fibrosum, 1 ~ 20 part of the edible ethanol of 1 ~ 20 part of content of Radix Glycyrrhizae more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of Citrus aurantium L. var. amara Engl.s, 15 ~ 20 parts in the Radix Rehmanniae; 15 ~ 20 parts of Cortex Moutans, 15 ~ 20 parts of Radix Paeoniae Rubra, 15 ~ 20 parts of the Rhizoma Anemarrhenaes; 15 ~ 20 parts of Flos Loniceraes, 15 ~ 20 parts of Fructus Forsythiaes, 15 ~ 20 parts on Folium Bambusae; 15 ~ 20 parts of Gypsum Fibrosum, 15 ~ 20 parts of 15 ~ 20 parts of Radix Glycyrrhizae, the content edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, Citrus aurantium L. var. amara Engl., the Radix Rehmanniae, Cortex Moutan, Radix Paeoniae Rubra, the Rhizoma Anemarrhenae, Flos Lonicerae, Fructus Forsythiae, Folium Bambusae, Gypsum Fibrosum and the Radix Glycyrrhizae of said weight proportion, according to the conventional method for distilling of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add the edible ethanol of content more than 95% of said weight proportion, be mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrating sterilization, fill according to quantity, the medicine of medicine dermatitis.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional method for distilling of said Chinese medicine can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of drug eruption; Select Flos Rosae Rugosae, Citrus aurantium L. var. amara Engl., the Radix Rehmanniae, Cortex Moutan, Radix Paeoniae Rubra, the Rhizoma Anemarrhenae, Flos Lonicerae, Fructus Forsythiae, Folium Bambusae, Gypsum Fibrosum, Radix Glycyrrhizae for use; With being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, process to contain pure Chinese medicine extraction liquid.Employing is main to control, and control the bonded method of supporting, but not only also external of oral administration of the medicine of processing is a kind of reasonable recipe, and compatibility is simplified, the medicine of the medicine dermatitis of determined curative effect, treating both the principal and secondary aspects of a disease.
The Radix Rehmanniae is cool in nature, and sweet in the mouth is gone into the heart, liver, kidney channel, nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.The Cortex Moutan cold nature, bitter in the mouth is hot, goes into the heart, liver, kidney channel; Purify the blood promoting blood circulation to remove blood stasis.The Radix Paeoniae Rubra nature and flavor are bitter, are slightly cold, and return Liver Channel, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, pain relieving.Rhizoma Anemarrhenae nature and flavor are bitter, and are cold, go into lung, stomach, kidney channel; Nourishing YIN to lower pathogenic fire is moisturized laxation.The Flos Lonicerae nature and flavor are sweet, and are cold, go into lung, stomach warp; Heat clearing away, detoxifcation.The Fructus Forsythiae nature and flavor are bitter, and the heart, liver, gallbladder meridian are gone in cold; Heat clearing away, detoxifcation, eliminating stagnation, detumescence.Folium Bambusae property slightly sweet flavor, cold, go into the heart, lung, gallbladder, stomach warp; Clearing heat and relieving fidgetness, the diuresis of promoting the production of body fluid.Gypsum Fibrosum heat clearing away cooling, promoting the production of body fluid to quench thirst; Gypsum Fibrosum preparata heat clearing away, convergence, granulation promoting.The Radix Glycyrrhizae nature and flavor are sweet, and are flat, go into spleen, stomach, lung meridian; With middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.
Medicine of the present invention is formed by xijiao Dihuang Tang and Baihu Tang increase and decrease.Select the Radix Rehmanniae, Cortex Moutan, Radix Paeoniae Rubra clearing away heat from YING and blood systems for use, the Rhizoma Anemarrhenae, Gypsum Fibrosum removing summer-heat flesh heat; The light fresh breeze heat of Folium Bambusae; Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae heat-clearing and toxic substances removing.All medicines share, and play clearing away heat from YING and blood systems altogether, the merit of the removing toxic substances that expels the heat-evil.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The Citrus aurantium L. var. amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two to be transferred, eliminating turbid pathogen with aromatics, the appetizing of being amusing, the strength enhancing that absorbs the drug when oral.The edible ethanol blood circulation promoting and blood stasis dispelling of content more than 95% promotes that drug osmotic to cell absorbs, and auxiliary taste absorb to improve curative effect when oral; Outer time spent skin expansion pore is to strengthen the drug transdermal trap.
Medicine of the present invention can also be smeared the affected part with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
Medicine dermatitis curative effect of the present invention is obvious, and clinical usefulness repeatly, effect are very prompt.Medicine of the present invention is through clinical 100 routine patients' clinical verification, and curing number is 80 examples, and significant figure is 16 examples, and invalid number is 4 examples, and total effective rate reaches 96%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, to enumerate model case following at present:
Case 1: certain man 22 years old, suffer from drug eruption, skin pruritus, whole body play erythra.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above symptom was alleviated in 3 days, eliminated in 15 days.Paying a return visit after 12 months does not have recurrence.
Case 2: certain woman 17 years old, suffer from drug eruption, whole skin pruritus, pimpling.External medicine of the present invention is smeared affected part and whole body, and every day 2 times, each 10 milliliters, repeatedly smear in the affected part.Above symptom was alleviated in 2 days, eliminated in 13 days.Paying a return visit after 12 months does not have recurrence.
Case 3: certain woman 39 years old, suffer from drug eruption, skin pruritus, scorching hot, red swollen a, vesicle.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body, and every day 2 times, each 10 milliliters, whole body is repeatedly smeared.Above symptom is oral to be alleviated after 1 day with external, eliminates in 10 days.Paying a return visit after 12 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of Citrus aurantium L. var. amara Engl.s, 20 parts in the Radix Rehmanniae, 16 parts of Cortex Moutans, 16 parts of Radix Paeoniae Rubra; 15 parts of the Rhizoma Anemarrhenaes, 18 parts of Flos Loniceraes, 16 parts of Fructus Forsythiaes, 18 parts on Folium Bambusae; 19 parts of Gypsum Fibrosum, 20 parts of Radix Glycyrrhizae adopt the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and are subsequent use.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the medicine dermatitis of oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of Citrus aurantium L. var. amara Engl.s, 18 parts in the Radix Rehmanniae, 18 parts of Cortex Moutans, 19 parts of Radix Paeoniae Rubra, 20 parts of the Rhizoma Anemarrhenaes, 19 parts of Flos Loniceraes, 20 parts of Fructus Forsythiaes, 18 parts on Folium Bambusae, 18 parts of Gypsum Fibrosum, 18 parts of Radix Glycyrrhizae, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of Citrus aurantium L. var. amara Engl.s, 19 parts in the Radix Rehmanniae, 19 parts of Cortex Moutans, 19 parts of Radix Paeoniae Rubra, 20 parts of the Rhizoma Anemarrhenaes, 20 parts of Flos Loniceraes, 20 parts of Fructus Forsythiaes, 20 parts on Folium Bambusae, 19 parts of Gypsum Fibrosum, 19 parts of Radix Glycyrrhizae, content are 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 15 parts of Flos Rosae Rugosaes, and 16 parts of Citrus aurantium L. var. amara Engl.s, 16 parts in the Radix Rehmanniae, 17 parts of Cortex Moutans, 18 parts of Radix Paeoniae Rubra, 17 parts of the Rhizoma Anemarrhenaes, 16 parts of Flos Loniceraes, 17 parts of Fructus Forsythiaes, 18 parts on Folium Bambusae, 16 parts of Gypsum Fibrosum, 16 parts of Radix Glycyrrhizae, content are 16 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 17 parts of Flos Rosae Rugosaes, and 18 parts of Citrus aurantium L. var. amara Engl.s, 17 parts in the Radix Rehmanniae, 18 parts of Cortex Moutans, 18 parts of Radix Paeoniae Rubra, 19 parts of the Rhizoma Anemarrhenaes, 19 parts of Flos Loniceraes, 17 parts of Fructus Forsythiaes, 18 parts on Folium Bambusae, 17 parts of Gypsum Fibrosum, 20 parts of Radix Glycyrrhizae, content are 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 20 parts of Citrus aurantium L. var. amara Engl.s, 19 parts in the Radix Rehmanniae, 20 parts of Cortex Moutans, 18 parts of Radix Paeoniae Rubra, 19 parts of the Rhizoma Anemarrhenaes, 18 parts of Flos Loniceraes, 18 parts of Fructus Forsythiaes, 19 parts on Folium Bambusae, 17 parts of Gypsum Fibrosum, 18 parts of Radix Glycyrrhizae, content are 20 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (1)
1. the medicine of a medicine dermatitis is characterized in that being processed by following method:
(1) takes by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of Citrus aurantium L. var. amara Engl.s, 20 parts in the Radix Rehmanniae, 16 parts of Cortex Moutans, 16 parts of Radix Paeoniae Rubra; 15 parts of the Rhizoma Anemarrhenaes, 18 parts of Flos Loniceraes, 16 parts of Fructus Forsythiaes, 18 parts on Folium Bambusae; 19 parts of Gypsum Fibrosum, 20 parts of Radix Glycyrrhizae adopt the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and are subsequent use;
(2) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use;
(3) above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the medicine dermatitis of for oral administration or external carries out fill under aseptic condition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010264930XA CN101987180B (en) | 2010-08-27 | 2010-08-27 | Medicine for treating dermatitis medicamentosa and preparation method thereof |
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| CN201010264930XA CN101987180B (en) | 2010-08-27 | 2010-08-27 | Medicine for treating dermatitis medicamentosa and preparation method thereof |
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| CN101987180A CN101987180A (en) | 2011-03-23 |
| CN101987180B true CN101987180B (en) | 2012-11-14 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103393816A (en) * | 2013-08-22 | 2013-11-20 | 王爱枝 | Medicine for treating dermatitis, and preparation method of medicine |
| CN105079587A (en) * | 2015-10-11 | 2015-11-25 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating dermatitis medicamentosa |
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Non-Patent Citations (7)
| Title |
|---|
| 南京中医药大学.玫瑰花 |
| 南京中医药大学.玫瑰花;玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748,2098. * |
| 张兆旺，等.中药合剂（含口服液） |
| 张兆旺,等.中药合剂(含口服液)渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105,185-187. * |
| 渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105，185-187. |
| 玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748，2098. |
| 许成吉，等.皮炎汤.《中国当代名医名方精选》.延边人民出版社,1992,286-287. * |
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