CN101259188B - Chinese medicine for treating chronic kidney disease and preparation thereof - Google Patents
Chinese medicine for treating chronic kidney disease and preparation thereof Download PDFInfo
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- CN101259188B CN101259188B CN2008100272142A CN200810027214A CN101259188B CN 101259188 B CN101259188 B CN 101259188B CN 2008100272142 A CN2008100272142 A CN 2008100272142A CN 200810027214 A CN200810027214 A CN 200810027214A CN 101259188 B CN101259188 B CN 101259188B
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Abstract
The invention relates to Chinese medicine used for treating chronic kidney disease, especially for treating kidney inflammation, invisible kidney inflammation and nephritic syndrome, and a preparation method of the Chinese medicine. The medicine is made of yerbadetajo, Ligustrum lucidum, Leonurus japonicus, Salvia, Rehmanniae, Lonicera confuse, Madder, Lycium Chinese Mill and Scorpion. The medicine has the efficacy of replenishing vital essence, tonifying kidney-yin, activating blood and dissolving stasis. The medicine is mainly applicable to treating kidney deficiency as well as the chronic kidney disease, the invisible kidney inflammation and the nephritic syndrome and also can be used for treating the nephritic syndrome in conjunction with western medicine such as Glucocorticoid. The medicine can improve curative effect, put off recurrence and reduce the times of recurrence. The medicine of the invention can be made into any formulation which is suitable for clinical treatment, including powders, decoction, mixture, oral liquor, capsule, granular formulation and a condensed pill and so on.
Description
Technical field
The present invention relates to a kind ofly treat chronic renal disease, particularly treat Chinese medicine based on the chronic nephritis of suffering from a deficiency of the kidney, latent nephritis, the nephrotic syndrome and preparation method thereof, also be used to cooperate Western medicine therapeutic alliance nephrotic syndromes such as glucocorticoid, can reduce the consumption and the side effect of Western medicine such as hormone significantly, improve curative effect, postpone recurrence time, reduce recurrent number.
Background technology
Renal glomerular disease means that has a similar clinical manifestation (as hematuria, albuminuria, hypertension etc.), but the cause of disease, pathogenesis, pathological change, the course of disease and prognosis be not quite similar, and pathological changes is mainly involved the disease of two kidney glomerule.Be divided into chronic nephritis, latent nephritis, the nephrotic syndrome etc. according to clinical manifestation.
The one group of immune disease that is primary in glomerule that chronic glomerulonephritis (abbreviation chronic nephritis) is made up of multiple reason, multiple histological type.Clinical characters is onset concealment, and the course of disease is tediously long, asymptomatic stage that can be for some time, and routine urianlysis has albuminuria, hematuria and cylinderuria in various degree, and most patient has edema, hypertension and the renal function injury of varying degree.The chronic nephritis sickness rate is higher, is more common in person between twenty and fifty, and the male is more than the women.Along with the development of the state of an illness, the patient can renal failure occur behind 2-3 or 20-30, be China's main diseases of causing chronic renal failure because of, account for 64.6%, become the principal disease that influences health of people.Chinese medicine does not have the name of chronic nephritis, and the description of its symptom sporadically appears in categories such as the edema of the traditional Chinese medical science, asthenia, lumbagos.Yet after oedema due to chronic nephritis disappeared, often pathological changes still existed, and part patient does not have edema performance and serve as mainly to show with hypertension or other symptom, even shows as asymptomatic proteinuria or albuminuria, and the chronic nephritis doctor trained in Western medicine does not still have effective therapy at present.
Latent nephritis claim again asymptomatic proteinuria and (or) hematuria, clinical with mild to moderate albuminuria (＜2g/d) and (or) glomerular hematuria, without edema, hypertension and azotemia are feature, the state of an illness is touching, and outbreak repeatedly is a great problem in the treatment.Doctor trained in Western medicine does not still have effective Therapeutic Method at present for invisible brightic treatment, mainly is prevention and active treatment infection and forbids to use the nephrotoxicity medicine.Therefore seeking effective ways, to treat invisible glomerulonephritis significant.
(Nephrotic Syndrome is that it accounts for 70%～90% in child's renal glomerular disease, also account for 20%～30% in the adult in order to one group of syndrome group in the summary renal glomerular disease NS) to nephrotic syndrome.All have clinically a large amount of albuminuria (every day＞3.5g), hypoproteinemia (albumin＜30g/L), obviously edema, hyperlipemia (characteristic person such as serum cholesterol＞6.5mmol/L) can examine and is nephrotic syndrome.Nephrotic syndrome is at the clinical branch that constitutional and Secondary cases are arranged.The nephrotic syndrome course of disease is long, the relapse rate height, and simple western medicine treatment often can not obtain ideal effect, some intractable nephrotic syndromes especially, clinical treatment is often more thorny.And adopt the method treatment nephrotic syndrome of the combination of Chinese and Western medicine, and not only enlarged the treatment approach, and clinical confirmation obtained gratifying curative effect, be considered to comparatively ideal therapeutic scheme.
From immune angle, nephropathy takes place to lack of proper care relevantly with immunologic homeostasis, and kidney-reinforcing drug, blood circulation and stasis-eliminating medicine have the effect of stable body's immunity.Medicine of the present invention is by the adjustment body's immunity, and microcirculation improvement reverses some pathological processes of body, thus the purpose that reaches treatment and repair.
At present can be actually rare for the medicine of the treatment chronic nephritis of practical application, latent nephritis, nephrotic syndrome.Though prior art has disclosed the medicine of multiple different treatment chronic nephritis, latent nephritis, nephrotic syndrome, for relevant report also being arranged with similar products like of the present invention, but, up to now, the concrete proportioning raw materials of having put down in writing medicine of the present invention without any report concerns that also nobody disclosed and selects the made medicine of proportioning raw materials relation of the present invention to have beat all therapeutic effect.
The inventor is through for many years clinical research and practice summary, medicine to original treatment chronic nephritis, latent nephritis, nephrotic syndrome on the traditional Chinese medicine theory basis improves, the medicine of the treatment chronic nephritis that exploitation makes new advances, latent nephritis, nephrotic syndrome.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of chronic nephritis, latent nephritis, nephrotic syndrome, this medicine is the Chinese medicine pharmaceutical composition, is principal agent with Herba Ecliptae, Fructus Ligustri Lucidi, is equipped with other former medicines and makes.Another object of the present invention provides manufacturing method for above mentioned medicine, and this method is a raw material with the Chinese medicine crude drug, makes through modern pharmaceutical technology.Further object of the present invention provides the application of said medicine in treatment chronic nephritis, latent nephritis, nephrotic syndrome.
The inventor is according to chronic nephritis, latent nephritis, the theory of Chinese medical science of nephrotic syndrome and modern medicine study, in conjunction with clinical experience for many years, from thousands of years immense Chinese medicine by according to filter out several Chinese medicines and form prescription, be applied to clinical back and find that medicine of the present invention is in the treatment chronic nephritis, latent nephritis, there is better curative effect the nephrotic syndrome aspect, be mainly used in the chronic nephritis of treatment to suffer from a deficiency of the kidney, latent nephritis, the nephrotic syndrome, also be used to cooperate Western medicine therapeutic alliance nephrotic syndromes such as glucocorticoid, can reduce the consumption and the side effect of Western medicine such as hormone significantly, improve curative effect, postpone recurrence time, reduce recurrent number.
Chinese medicine of the present invention is formulated by the following weight proportion raw material:
China ink Herba Ecliptae 80-200 part Fructus Ligustri Lucidi 80-200 part
Herba Leonuri 120-250 part Radix Salviae Miltiorrhizae 80-200 part
Radix Rehmanniae 80-200 part Flos Lonicerae 50-150 part
Radix Rubiae 50-150 part Cortex Lycii 50-150 part
Scorpio 0-40 part
The weight proportion of each raw material of optimization formula of the present invention is:
Herba Ecliptae 125-155 part Fructus Ligustri Lucidi 125-155 part
Herba Leonuri 170-205 part Radix Salviae Miltiorrhizae 125-155 part
Radix Rehmanniae 125-155 part Flos Lonicerae 75-95 part
Radix Rubiae 75-95 part Cortex Lycii 75-95 part
Scorpio 15-25 part
Each raw material weight proportioning of optimum formula of the present invention is:
141 parts of 141 parts of Fructus Ligustri Lucidi of Herba Ecliptae
141 parts of 188 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
84 parts of 141 parts of Flos Lonicerae of Radix Rehmanniae
84 parts of 84 parts of Cortex Lycii of Radix Rubiae
19 parts of Scorpios
This side belongs to clinical experience side, and Herba Ecliptae, Fructus Ligustri Lucidi share the moon of nourishing the liver and kidney in the side, but Herba Ecliptae and cooling blood for hemostasis, and two medicines are monarch.The Radix Salviae Miltiorrhizae promoting blood circulation and hemostasis; The Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, the auxiliary monarch drug of two medicines is strengthened the effect of nourishing yin and stopping bleeding, is ministerial drug.The Herba Leonuri blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema; Honeysuckle flower for reducing fever, detoxicating, dispelling wind and heat pathogens; The Radix Rubiae cooling blood for hemostasis is invigorated blood circulation; The Cortex Lycii clearing away deficiency-heat; Four medicines have share the power that assistant helps, and are adjuvant drug.Scorpio endogenous wind stopping relieving convulsion, dispelling toxins and dredging collaterals is messenger drug.All medicines share, and have the effect of enriching yin and nourishing kidney, blood circulation promoting and blood stasis dispelling.
Chinese medicine of the present invention can be made any clinical dosage form that is suitable for, for example powder, decoction, mixture, oral solution, capsule, granule, concentrated pill etc.
Need to prove that Chinese medicine of the present invention can also contain other optional members, for example improve the raw material of Chinese medicine of the corresponding symptom of nephropathy patient; Chinese medicine of the present invention also can be used with the Western medicine merging of treatment nephropathy and make the Chinese medicine and western medicine compound preparation simultaneously.Therefore increase simply or other raw material of Chinese medicine of multi-flavor on the basis of medicine in the present invention, perhaps the Western medicine of Chinese medicine of the present invention and treatment nephropathy is merged to use and make the Chinese medicine and western medicine compound preparation and also belong to the scope of protection of the invention.General below 50% of medicine total amount in the present invention of the amount of these optional members, preferred below 20%.
Experiment 1: treatment chronic nephritis observation of curative effect
Using the present invention is that main integrative medicine therapy is treated 50 routine chronic nephritis patients, and does contrast with western medicine group and observe, and 50 examples are organized in treatment as a result, alleviate 17 examples (34%) fully, alleviate 16 examples (32%) substantially, 11 examples that take a turn for the better (22%), invalid 6 examples (12%), total effective rate 88%.Matched group 50 examples are alleviated 3 examples (6%) fully, alleviate 13 examples (26%) substantially, 12 examples that take a turn for the better (24%), invalid 22 examples (44%), total effective rate 56%.The curative effect of treatment group obviously is better than matched group (P＜0.01).
Experiment 2: treatment latent nephritis observation of curative effect
Using the present invention is that main integrative medicine therapy is treated 60 routine latent nephritis patients, and do contrast with western medicine group and observe, 60 examples are organized in treatment as a result, alleviate 14 examples (23.33%) fully, basic 24 examples (40.00%) of alleviating, 15 examples that take a turn for the better (25.00%), invalid 7 examples (11.67%), total effective rate 88.33%.Matched group 60 examples are alleviated 6 examples (10.00%) fully, alleviate 14 examples (23.33%) substantially, 14 examples that take a turn for the better (23.33%), invalid 26 examples (43.33%), total effective rate 56.67%.The curative effect of treatment group obviously is better than matched group (P＜0.01).
Experiment 3: treatment nephrotic syndrome observation of curative effect
Using the present invention is that main integrative medicine therapy is treated 66 routine nephrotic syndrome patients, and do contrast with western medicine group and observe, 66 examples are organized in treatment as a result, alleviate 23 examples (34.85%) fully, basic 22 examples (33.33%) of alleviating, 12 examples that take a turn for the better (18.18%), invalid 9 examples (13.64%), total effective rate 86.36%.Matched group 66 examples are alleviated 13 examples (19.70%) fully, alleviate 11 examples (16.67%) substantially, 14 examples that take a turn for the better (21.21%), invalid 28 examples (42.42%), total effective rate 57.58%.The curative effect of treatment group obviously is better than matched group (P＜0.01).
Experiment 4: external and zoopery
The inventor discovers that the Radix Salviae Miltiorrhizae among the present invention can increase the c-myc protein expression and cell death inducing, thereby suppresses the kidney fibroblast proliferation; Scorpio can reduce rat membraneous nephritis albuminuria, suppresses the interleukin-1 activity, and the nephrectasia blood capillary, suppresses thrombosis and inflammatory cytokine and discharges, thereby alleviate the kidney pathological change.The present invention can significantly reduce cytokine-expressings such as model mouse nephridial tissue RANTES, significantly alleviates accumulating of interstitial cell infiltration and messangial cell epimatrix, and renal function protecting delays the generation and the development of model mouse nephropathy.Itself and prednisone share, and are heightening the effect of a treatment and to reduce aspect the side effect effect remarkable.Acute toxicity test shows safety non-toxic of the present invention.
The specific embodiment
Following listed examples only is used for illustrative purposes, does not constitute any limitation of the invention.
Embodiment 1:
80 parts of 80 parts of Fructus Ligustri Lucidi of Herba Ecliptae
80 parts of 120 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
50 parts of 80 parts of Flos Lonicerae of Radix Rehmanniae
50 parts of 50 parts of Cortex Lycii of Radix Rubiae
The preparation method of powder: take by weighing each raw material by above-mentioned weight, clean roguing, dry, pulverize, sieve, again pack.
The preparation method of decoction: take by weighing each raw material by above-mentioned weight, clean roguing, decoct with water the back packing promptly.
The preparation method of capsule: take by weighing each raw material by above-mentioned weight, clean roguing, use boiling water extraction 2 times, each 2 hours, filter, merging filtrate concentrates, and adds ethanol to containing alcohol amount 70%, leaves standstill 12 hours; Get supernatant, recovered alcohol is concentrated into the thick paste shape; Add starch, stir, cold drying, grinding and sieving, with empty hard capsule packing promptly.
Embodiment 2:
200 parts of 200 parts of Fructus Ligustri Lucidi of Herba Ecliptae
200 parts of 250 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
150 parts of 200 parts of Flos Lonicerae of Radix Rehmanniae
150 parts of 150 parts of Cortex Lycii of Radix Rubiae
40 parts of Scorpios
The preparation method of powder: take by weighing each raw material by above-mentioned weight, clean roguing, dry, pulverize, sieve, again pack.
The preparation method of decoction: take by weighing each raw material by above-mentioned weight, clean roguing, decoct with water the back packing promptly.
The preparation method of capsule: take by weighing each raw material by above-mentioned weight, clean roguing, use boiling water extraction 2 times, each 2 hours, filter, merging filtrate concentrates, and adds ethanol to containing alcohol amount 70%, leaves standstill 12 hours; Get supernatant, recovered alcohol is concentrated into the thick paste shape; Add starch, stir, cold drying, grinding and sieving, with empty hard capsule packing promptly.
Embodiment 3:
125 parts of 125 parts of Fructus Ligustri Lucidi of Herba Ecliptae
125 parts of 170 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
75 parts of 125 parts of Flos Lonicerae of Radix Rehmanniae
75 parts of 75 parts of Cortex Lycii of Radix Rubiae
15 parts of Scorpios
The preparation method of powder: take by weighing each raw material by above-mentioned weight, clean roguing, dry, pulverize, sieve, again pack.
The preparation method of decoction: take by weighing each raw material by above-mentioned weight, clean roguing, decoct with water the back packing promptly.
The preparation method of capsule: take by weighing each raw material by above-mentioned weight, clean roguing, use boiling water extraction 2 times, each 2 hours, filter, merging filtrate concentrates, and adds ethanol to containing alcohol amount 70%, leaves standstill 12 hours; Get supernatant, recovered alcohol is concentrated into the thick paste shape; Add starch, stir, cold drying, grinding and sieving, with empty hard capsule packing promptly.
Embodiment 4:
155 parts of 155 parts of Fructus Ligustri Lucidi of Herba Ecliptae
155 parts of 205 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
95 parts of 155 parts of Flos Lonicerae of Radix Rehmanniae
95 parts of 95 parts of Cortex Lycii of Radix Rubiae
25 parts of Scorpios
The preparation method of powder: take by weighing each raw material by above-mentioned weight, clean roguing, dry, pulverize, sieve, again pack.
The preparation method of decoction: take by weighing each raw material by above-mentioned weight, clean roguing, decoct with water the back packing promptly.
The preparation method of capsule: take by weighing each raw material by above-mentioned weight, clean roguing, use boiling water extraction 2 times, each 2 hours, filter, merging filtrate concentrates, and adds ethanol to containing alcohol amount 70%, leaves standstill 12 hours; Get supernatant, recovered alcohol is concentrated into the thick paste shape; Add starch, stir, cold drying, grinding and sieving, with empty hard capsule packing promptly.
Embodiment 5:
141 parts of 141 parts of Fructus Ligustri Lucidi of Herba Ecliptae
141 parts of 188 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
84 parts of 141 parts of Flos Lonicerae of Radix Rehmanniae
84 parts of 84 parts of Cortex Lycii of Radix Rubiae
19 parts of Scorpios
The preparation method of powder: take by weighing each raw material by above-mentioned weight, clean roguing, dry, pulverize, sieve, again pack.
The preparation method of decoction: take by weighing each raw material by above-mentioned weight, clean roguing, decoct with water the back packing promptly.
The preparation method of capsule: take by weighing each raw material by above-mentioned weight, clean roguing, use boiling water extraction 2 times, each 2 hours, filter, merging filtrate concentrates, and adds ethanol to containing alcohol amount 70%, leaves standstill 12 hours; Get supernatant, recovered alcohol is concentrated into the thick paste shape; Add starch, stir, cold drying, grinding and sieving, with empty hard capsule packing promptly.
Claims (3)
1. Chinese medicine for the treatment of chronic renal disease, it is made by the following weight proportion raw material;
141 parts of 141 parts of Fructus Ligustri Lucidi of Herba Ecliptae
141 parts of 188 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
84 parts of 141 parts of Flos Lonicerae of Radix Rehmanniae
84 parts of 84 parts of Cortex Lycii of Radix Rubiae
19 parts of Scorpios.
2. Chinese medicine according to claim 1 is characterized in that making any clinical dosage form that is suitable for by described proportioning raw materials.
3. a treatment chronic renal disease preparation method of Chinese medicine comprises;
A. each crude drug takes by weighing by following part by weight:
141 parts of 141 parts of Fructus Ligustri Lucidi of Herba Ecliptae
141 parts of 188 parts of Radix Salviae Miltiorrhizaes of Herba Leonuri
84 parts of 141 parts of Flos Lonicerae of Radix Rehmanniae
84 parts of 84 parts of Cortex Lycii of Radix Rubiae
19 parts of Scorpios
B. take by weighing each raw material by above-mentioned weight, clean roguing, use boiling water extraction 2 times, each 2 hours, filter;
C. merging filtrate concentrates, and adds ethanol to containing alcohol amount 70%, leaves standstill 12 hours, gets supernatant, recovered alcohol;
D. be concentrated into the thick paste shape, add starch, stir, after the cold drying, pulverize, promptly with empty hard capsule packing.
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| CN2008100272142A CN101259188B (en) | 2008-04-03 | 2008-04-03 | Chinese medicine for treating chronic kidney disease and preparation thereof |
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| CN2008100272142A CN101259188B (en) | 2008-04-03 | 2008-04-03 | Chinese medicine for treating chronic kidney disease and preparation thereof |
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| CN101259188B true CN101259188B (en) | 2011-06-15 |
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| CN106421451A (en) * | 2016-08-29 | 2017-02-22 | 董凤岩 | Medicine for treating chronic nephritis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062168A (en) * | 2007-06-07 | 2007-10-31 | 张德勇 | Chinese traditional combination for treating chronic nephritis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062168A (en) * | 2007-06-07 | 2007-10-31 | 张德勇 | Chinese traditional combination for treating chronic nephritis |
Non-Patent Citations (4)
| Title |
|---|
| 叶任高等.中西医结合治疗原发性肾小球肾炎.《新医学》.1990,第21卷(第9期),第460-461页. * |
| 张兆旺主编.硬胶囊剂的制备.《中药药剂学》.2003,(第1版),第353页. * |
| 徐明.提高隐匿性肾炎疗效应注意的几个问题.《四川中医》.2006,第24卷(第2期),第38-39页. * |
| 阳晓等.中西医结合治疗原发性隐匿性肾炎51例疗效观察.《新中医》.2000,第32卷(第4期),第13-15页. * |
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