CN105106488A - Traditional Chinese medicine composition for treating infantile eczema - Google Patents
Traditional Chinese medicine composition for treating infantile eczema Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating infantile eczema. The traditional Chinese medicine composition is prepared from raw material medicines as follows: 30-50 parts of argy wormwood leaves, 10-30 parts of plantain herb, 20-50 parts of garden balsam stem, 10-30 parts of mulberry leaves, 15-50 parts of parslane herb, 10-30 parts of phellodendron bark, 10-30 parts of tree peony barks, 5-25 parts of pricklyash peel, 10-30 parts of densefruit pittany root-bark, 5-25 parts of common selfheal fruit-spike, 4-8 parts of liquorice, 10-15 parts of dandelions, 8-15 parts of cicada slough, 20-30 parts of swordlike atractylodes rhizomes, 2-6 parts of baical skullcap roots, 5-20 parts of honeysuckle, 8-14 parts of belvedere fruit, 10-25 parts of towel gourd seeds, 20-40 parts of lightyellow sophora roots and 10-25 parts of aloe. The traditional Chinese medicine composition can be prepared to form decoction or an ointment, the sick part is washed for 2-3 times with the decoction every day or is coated with the ointment in the treatment process of infantile eczema, the traditional Chinese medicine composition has a remarkable efficacy on infantile eczema and has a remarkable effect after being used for 7 days, the area of eczema is greatly reduced, eczema is basically cured after 15 days, the effective rate reaches 100%, and infantile eczema cannot relapse.
Description
Technical field
The present invention relates to Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of infantile eczema.
Background technology
Eczema is the inflammatory dermatoses of a kind of common epidermis caused by multiple internal and external factor and high dermis. its feature is conscious violent pruritus, and skin lesion pleomorphism is symmetrical, has and oozes out tendency, the chronic course of disease, easy recurrent exerbation.The multiple child be born within 5 years old, is also found in adult, infects after herpes simplex virus, about through 5-9 days incubation periods, and high heat (39-40 DEG C), general malaise, Nausea and vomiting and the poisoning symptom such as drowsiness suddenly.Erythra starts from original dermatosis positions such as face, neck, upper limb and trunk, also can occur on normal skin.Lower limb are rare., there is many intensive vesicles suddenly, become rapidly pustule, there is omphalos on bleb top, base substrate is obviously red and swollen in erythra feature: original erythra increases the weight of.Sometimes erythra is fused into lamellar, and after 1-2 week, erythra drying incrustation, leaves over pigmentation and shallow cicatrix.Neighbouring lymphadenectasis.Can concurrent pharyngitis, tonsillitis, rhinitis, otitis media, conjunctivitis, keratitis or corneal ulcer, pneumonia and encephalitis etc.
At present, the preparation about infantile eczema has had a lot, is more common in Western medicine, but uses Western medicine to have certain dependency, and has suitable side effect, market also has much about the treatment of Chinese medicine, but it is little to reach ideal effect.
Summary of the invention:
For above technological deficiency, the present invention in depth studies and creative work through inventor, obtains a kind of pharmacy prescription for the treatment of eczema, especially infantile eczema is applicable to, for the discovery that the present inventor is pleasantly surprised, the effect of the medicament of this prescription is good, good stability.
Inventor carries out a large amount of investigative test to the consumption of drug component, each raw material dosage all has good curative effect in weight portion scope of the present invention, described formula and component are: Folium Artemisiae Argyi 30-50 part, Herba Plantaginis 10-30 part, Herba speranskiae tuberculatae 20-50 part, Folium Mori 10-30 part, Herba Portulacae 15-50 part, Cortex Phellodendri 10-30 part, Cortex Moutan 10-30 part, Pericarpium Zanthoxyli 5-25 part, Cortex Dictamni 10-30 part, XIAKUQIU 5-25 part, Radix Glycyrrhizae 4-8 part, Herba Taraxaci 10-15 part, Periostracum Cicadae 8-15 part, Rhizoma Atractylodis 20-30 part, Radix Scutellariae 2-6 part, Flos Lonicerae 5-20 part, Fructus Kochiae 8-14 part, Semen Luffae 10-25 part, Radix Sophorae Flavescentis 20-40 part, Aloe 10-25 part.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Folium Artemisiae Argyi 35-45 part, Herba Plantaginis 20-40 part, Herba speranskiae tuberculatae 25-45 part, Folium Mori 15-20 part, Herba Portulacae 35-40 part, Cortex Phellodendri 20-25 part, Cortex Moutan 18-22 part, Pericarpium Zanthoxyli 8-12 part, Cortex Dictamni 18-24 part, XIAKUQIU 13-18 part, Radix Glycyrrhizae 6-8 part, Herba Taraxaci 10-14 part, Periostracum Cicadae 12-15 part, Rhizoma Atractylodis 24-30 part, Radix Scutellariae 2-4 part, Flos Lonicerae 10-16 part, Fructus Kochiae 11-14 part, Semen Luffae 11-15 part, Radix Sophorae Flavescentis 25-35 part, Aloe 17-20 part.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, most preferred formula is: Folium Artemisiae Argyi 40 parts, Herba Plantaginis 25 parts, Herba speranskiae tuberculatae 35 parts, 18 parts, Folium Mori, Herba Portulacae 37 parts, Cortex Phellodendri 22 parts, Cortex Moutan 20 parts, 10 parts, Pericarpium Zanthoxyli, Cortex Dictamni 20 parts, XIAKUQIU 15 parts, 6 parts, Radix Glycyrrhizae, Herba Taraxaci 12 parts, Periostracum Cicadae 12 parts, Rhizoma Atractylodis 24 parts, Radix Scutellariae 4 parts, Flos Lonicerae 16 parts, the Fructus Kochiae 11 parts, Semen Luffae 11 parts, Radix Sophorae Flavescentis 30 parts, Aloe 17 parts.
The function of each taste Chinese crude drug used in the Chinese medicine preparation for the treatment of eczema of the present invention is as follows:
Folium Artemisiae Argyi: bitter in the mouth, warm in nature.
Gui Jing: return liver,spleen,kidney warp.
Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding, vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.
Herba Portulacae: sour in the mouth, cold in nature.
Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, for bacillary dysentery, and acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea; Furuncle swelling toxin is controlled in external, eczema, herpes zoster.
Herba Plantaginis: sweet in the mouth, cold in nature.
Gui Jing: return liver, kidney, lung, small intestine meridian.
Function cures mainly: clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances, for edema oliguria, and the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Pericarpium Zanthoxyli: acrid in the mouth, warm in nature.
Gui Jing: return spleen, stomach, kidney channel.
Function cures mainly: warming middle-JIAO to relieve pain, killing parasites for relieving itching, external treatment eczema pruritus.
Cortex Dictamni: bitter in the mouth, cold in nature.
Gui Jing: return spleen, stomach, urinary bladder channel.
Function cures mainly: heat clearing and damp drying, removing toxic substances of dispeling the wind, and for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.
Herba speranskiae tuberculatae: bitter in the mouth, warm in nature.
Gui Jing: return liver, kidney channel.
Function cures mainly: expelling wind and removing dampness, and removing toxic substances pain relieving, for rheumatic arthritis, sore swollen toxin is controlled in external.
Folium Mori: sweet in the mouth, cold in nature.
Gui Jing: return lung, Liver Channel.
Function cures mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, and for anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Cortex Phellodendri: bitter in the mouth, cold in nature.
Gui Jing: return kidney, urinary bladder channel.
Function cures mainly: heat clearing and damp drying, and pathogenic fire purging removes steams, detoxification sore treatment, for damp-heat dysentery, and sore swollen toxin, eczema pruritus.
Cortex Moutan: bitter in the mouth, pungent, is slightly cold.
Gui Jing: GUIXIN, liver, kidney channel.
Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.
XIAKUQIU: bitter in the mouth, cold in nature.
Gui Jing: return liver, gallbladder meridian.
Function cures mainly: purging liver-fire, improving eyesight, mass dissipating and swelling eliminating, and for conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, acute mastitis, nodules of the breast, distending pain of the breast.
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
Herba Taraxaci: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach warp.
Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, for furuncle swelling toxin, and acute mastitis scrofula, conjunctival congestion pharyngalgia, lung, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Periostracum Cicadae: sweet in the mouth, cold in nature.
Gui Jing: return lung, Liver Channel.
Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic, for anemopyretic cold, and pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Rhizoma Atractylodis: acrid in the mouth, hardship, temperature.
Gui Jing: return spleen, stomach, Liver Channel.
Function cures mainly: drying damp and strengthening spleen, expelling wind and cold, improving eyesight, for distension and fullness in the abdomen, has loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
The Radix Astragali: sweet in the mouth, warm in nature.
Gui Jing: enter lung, spleen channel.
Function cures mainly: tonifying Qi and lifting yang, and consolidating superficial resistance, by antiperspirant, holds in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.
Flos Lonicerae: sweet in the mouth, cold in nature.
Gui Jing: enter lung, the heart, stomach warp.
Function cures mainly: the effect with heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind.
The Fructus Kochiae: acrid in the mouth, hardship, cold.
Gui Jing: return kidney, urinary bladder channel.
Function cures mainly: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, for difficulty and pain in micturition, and pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Semen Luffae: taste bitter in the mouth; Cold in nature
Function cures mainly: heat clearing away; Diuretic; Relieving constipation; Anthelmintic.
Aloe: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach, large intestine channel.
Function cures mainly: removing heat from the liver, relieving constipation, for constipation, and infantile malnutrition, infantile convulsion external treatment exudative dermatitis.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature.
Gui Jing: GUIXIN, liver, stomach, large intestine, urinary bladder channel.
Function cures mainly: heat clearing and damp drying, and parasite killing diuresis, has blood in stool for hematodiarrhoea, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, external treatment trichomonal vaginitis.
The described Chinese medicine composition for the treatment of infantile eczema of the present invention, wherein said Chinese medicine composition makes water decoction.
The preparation method that Chinese medicine composition of the present invention makes water decoction is:
1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
2) crude drug of formula ratio is put into appropriate pure water, after fast fire is fried open, then decoct 30 minutes slowly, pour out decocting liquid.
Can reuse once after the preparation of this Chinese medicine composition, one day potion.
According to the difference of patient, present invention also offers a kind of preparation method for the treatment of the Chinese medicine composition of infantile eczema, 1) described crude drug is pulverized and sieved powdered or through extracting obtained concentrated solution; 2) in first step gained, add adjuvant, make ointment.
The method comprises the steps:
1) Radix Sophorae Flavescentis, Pericarpium Zanthoxyli are broken into fine powder and cross 80-100 mesh sieve;
2) by Folium Artemisiae Argyi, Herba Plantaginis, Herba speranskiae tuberculatae, Folium Mori, Herba Portulacae, Cortex Phellodendri, Cortex Moutan, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, Periostracum Cicadae, Rhizoma Atractylodis, Radix Scutellariae, Flos Lonicerae, the Fructus Kochiae, Semen Luffae, Aloe soak by water twice, each 2-4h, merge decoction liquor, filter, heating is concentrated, obtains concentrated solution;
3) by 1) fine powder and 2 of step) concentrated solution of step mixs homogeneously, and obtains mixed liquor;
4) to 3) add pharmaceutically acceptable adjuvant in the mixed liquor of step, make ointment.
Pharmaceutical preparation of the present invention be ointment by weight part ratio be 1: 3.0-10.0 mixture and pharmaceutically acceptable adjuvant make, be more preferably that the Chinese medicine composition of 1:4.5-6.7 and pharmaceutically acceptable adjuvant are made by weight part ratio.
Pharmaceutically acceptable adjuvant of the present invention be selected from semi-synthetic fatty acid glyceride, Macrogol 4000, PEG400, Tween-80, polyoxyethylene, poloxamer, glycerin gelatine, glyceryl monostearate one or more; Further be preferably the mixture of semi-synthetic fatty acid glyceride and glyceryl monostearate.
Described Chinese medicine composition, in the application of eczema, is particluarly suitable for treating the application in infantile eczema.
In the therapeutic process of the present invention in treatment infantile eczema, water decoction is used to clean affected part 2-3 time every day, or/and be coated with ointment of the present invention, to infantile eczema, there is significant effect, within 7 days, have positive effect, eczema area greatly reduces, and within 15 days, is almost recovered, effective percentage 100%, rebound rate is 0%.
Compared with prior art, the present invention adopts pure Chinese traditional medicine dispensing in the present invention, has heat-clearing and toxic substances removing, an effect of the dissipating blood stasis that dispels the wind, dampness removing to stop itchin, effectively can treat eczema, and not easily recur, have no side effect; Adopt the Chinese crude drug that price is lower, be of value to the protection of environment, find in clinical trial; water decoction and ointment can be used alone; also can the two with the use of, better with the use of therapeutic effect, wherein preparation technology of the present invention comparatively simply can carry out suitability for industrialized production.
Specific embodiment
Embodiment 1: the preparation of water decoction
Folium Artemisiae Argyi 30g, Herba Plantaginis 10g, Herba speranskiae tuberculatae 20g, Folium Mori 10g, Herba Portulacae 15g, Cortex Phellodendri 10g, Cortex Moutan 10g, Pericarpium Zanthoxyli 5g, Cortex Dictamni 10g, XIAKUQIU 5g, Radix Glycyrrhizae 4g, Herba Taraxaci 10g, Periostracum Cicadae 8g, Rhizoma Atractylodis 20g, Radix Scutellariae 2g, Flos Lonicerae 5g, Fructus Kochiae 8g, Semen Luffae 10g, Radix Sophorae Flavescentis 20g, Aloe 10g.
Preparation technology:
1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
2) crude drug of formula ratio is put into appropriate pure water, after fast fire is fried open, then decoct 30 minutes slowly, pour out decocting liquid and use;
3) by step 2) this Chinese medicine composition recycling once.
Embodiment 2: the preparation of water decoction
Folium Artemisiae Argyi 50g, Herba Plantaginis 30g, Herba speranskiae tuberculatae 50g, Folium Mori 30g, Herba Portulacae 50g, Cortex Phellodendri 30g, Cortex Moutan 30g, Pericarpium Zanthoxyli 25g, Cortex Dictamni 30g, XIAKUQIU 25g, Radix Glycyrrhizae 8g, Herba Taraxaci 15g, Periostracum Cicadae 15g, Rhizoma Atractylodis 30g, Radix Scutellariae 6g, Flos Lonicerae 20g, Fructus Kochiae 14g, Semen Luffae 25g, Radix Sophorae Flavescentis 40g, Aloe 25g.
Preparation technology:
1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
2) crude drug of formula ratio is put into appropriate pure water, after fast fire is fried open, then decoct 30 minutes slowly, pour out decocting liquid and use;
3) by step 2) this Chinese medicine composition recycling once.
Embodiment 3: the preparation of water decoction
Folium Artemisiae Argyi 35g, Herba Plantaginis 20g, Herba speranskiae tuberculatae 25g, Folium Mori 15g, Herba Portulacae 35g, Cortex Phellodendri 20g, Cortex Moutan 18g, Pericarpium Zanthoxyli 8g, Cortex Dictamni 18g, XIAKUQIU 13g, Radix Glycyrrhizae 6g, Herba Taraxaci 10g, Periostracum Cicadae 12g, Rhizoma Atractylodis 24g, Radix Scutellariae 2g, Flos Lonicerae 10g, Fructus Kochiae 11g, Semen Luffae 11g, Radix Sophorae Flavescentis 25g, Aloe 17g.
Preparation technology:
1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
2) crude drug of formula ratio is put into appropriate pure water, after fast fire is fried open, then decoct 30 minutes slowly, pour out decocting liquid and use;
3) by step 2) this Chinese medicine composition recycling once.
Embodiment 4: the preparation of water decoction
Folium Artemisiae Argyi 45g, Herba Plantaginis 40g, Herba speranskiae tuberculatae 45g, Folium Mori 20g, Herba Portulacae 40g, Cortex Phellodendri 25g, Cortex Moutan 22g, Pericarpium Zanthoxyli 12g, Cortex Dictamni 24g, XIAKUQIU 18g, Radix Glycyrrhizae 8g, Herba Taraxaci 14g, Periostracum Cicadae 15g, Rhizoma Atractylodis 30g, Radix Scutellariae 4g, Flos Lonicerae 16g, Fructus Kochiae 14g, Semen Luffae 15g, Radix Sophorae Flavescentis 35g, Aloe 20g.
Preparation technology:
1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
2) crude drug of formula ratio is put into appropriate pure water, after fast fire is fried open, then decoct 30 minutes slowly, pour out decocting liquid and use;
3) by step 2) this Chinese medicine composition recycling once.
Embodiment 5: the preparation of water decoction
Folium Artemisiae Argyi 40g, Herba Plantaginis 25g, Herba speranskiae tuberculatae 35g, Folium Mori 18g, Herba Portulacae 37g, Cortex Phellodendri 22g, Cortex Moutan 20g, Pericarpium Zanthoxyli 10g, Cortex Dictamni 20g, XIAKUQIU 15g, Radix Glycyrrhizae 6g, Herba Taraxaci 12g, Periostracum Cicadae 12g, Rhizoma Atractylodis 24g, Radix Scutellariae 4g, Flos Lonicerae 16g, Fructus Kochiae 11g, Semen Luffae 11g, Radix Sophorae Flavescentis 30g, Aloe 17g.
Preparation technology:
1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
2) crude drug of formula ratio is put into appropriate pure water, after fast fire is fried open, then decoct 30 minutes slowly, pour out decocting liquid and use;
3) by step 2) this Chinese medicine composition recycling once.
Embodiment 6: the preparation of ointment
Folium Artemisiae Argyi 30g, Herba Plantaginis 10g, Herba speranskiae tuberculatae 20g, Folium Mori 10g, Herba Portulacae 15g, Cortex Phellodendri 10g, Cortex Moutan 10g, Pericarpium Zanthoxyli 5g, Cortex Dictamni 10g, XIAKUQIU 5g, Radix Glycyrrhizae 4g, Herba Taraxaci 10g, Periostracum Cicadae 8g, Rhizoma Atractylodis 20g, Radix Scutellariae 2g, Flos Lonicerae 5g, Fructus Kochiae 8g, Semen Luffae 10g, Radix Sophorae Flavescentis 20g, Aloe 10g.
Preparation technology:
1) Radix Sophorae Flavescentis, Pericarpium Zanthoxyli are broken into fine powder and cross 80-100 mesh sieve;
2) by Folium Artemisiae Argyi, Herba Plantaginis, Herba speranskiae tuberculatae, Folium Mori, Herba Portulacae, Cortex Phellodendri, Cortex Moutan, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, Periostracum Cicadae, Rhizoma Atractylodis, Radix Scutellariae, Flos Lonicerae, the Fructus Kochiae, Semen Luffae, Aloe soak by water twice, each 2-4h, merge decoction liquor, filter, heating is concentrated, obtains concentrated solution;
3) by 1) fine powder and 2 of step) concentrated solution of step mixs homogeneously, and obtains mixed liquor;
4) to 3) add pharmaceutically acceptable adjuvant in the mixed liquor of step, make ointment.
Embodiment 7: the preparation of ointment
Folium Artemisiae Argyi 50g, Herba Plantaginis 30g, Herba speranskiae tuberculatae 50g, Folium Mori 30g, Herba Portulacae 50g, Cortex Phellodendri 30g, Cortex Moutan 30g, Pericarpium Zanthoxyli 25g, Cortex Dictamni 30g, XIAKUQIU 25g, Radix Glycyrrhizae 8g, Herba Taraxaci 15g, Periostracum Cicadae 15g, Rhizoma Atractylodis 30g, Radix Scutellariae 6g, Flos Lonicerae 20g, Fructus Kochiae 14g, Semen Luffae 25g, Radix Sophorae Flavescentis 40g, Aloe 25g.
Preparation technology:
1) Radix Sophorae Flavescentis, Pericarpium Zanthoxyli are broken into fine powder and cross 80-100 mesh sieve;
2) by Folium Artemisiae Argyi, Herba Plantaginis, Herba speranskiae tuberculatae, Folium Mori, Herba Portulacae, Cortex Phellodendri, Cortex Moutan, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, Periostracum Cicadae, Rhizoma Atractylodis, Radix Scutellariae, Flos Lonicerae, the Fructus Kochiae, Semen Luffae, Aloe soak by water twice, each 2-4h, merge decoction liquor, filter, heating is concentrated, obtains concentrated solution;
3) by 1) fine powder and 2 of step) concentrated solution of step mixs homogeneously, and obtains mixed liquor;
4) to 3) add pharmaceutically acceptable adjuvant in the mixed liquor of step, make ointment.
Embodiment 8: the preparation of ointment
Folium Artemisiae Argyi 35g, Herba Plantaginis 20g, Herba speranskiae tuberculatae 25g, Folium Mori 15g, Herba Portulacae 35g, Cortex Phellodendri 20g, Cortex Moutan 18g, Pericarpium Zanthoxyli 8g, Cortex Dictamni 18g, XIAKUQIU 13g, Radix Glycyrrhizae 6g, Herba Taraxaci 10g, Periostracum Cicadae 12g, Rhizoma Atractylodis 24g, Radix Scutellariae 2g, Flos Lonicerae 10g, Fructus Kochiae 11g, Semen Luffae 11g, Radix Sophorae Flavescentis 25g, Aloe 17g.
Preparation technology:
1) Radix Sophorae Flavescentis, Pericarpium Zanthoxyli are broken into fine powder and cross 80-100 mesh sieve;
2) by Folium Artemisiae Argyi, Herba Plantaginis, Herba speranskiae tuberculatae, Folium Mori, Herba Portulacae, Cortex Phellodendri, Cortex Moutan, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, Periostracum Cicadae, Rhizoma Atractylodis, Radix Scutellariae, Flos Lonicerae, the Fructus Kochiae, Semen Luffae, Aloe soak by water twice, each 2-4h, merge decoction liquor, filter, heating is concentrated, obtains concentrated solution;
3) by 1) fine powder and 2 of step) concentrated solution of step mixs homogeneously, and obtains mixed liquor;
4) to 3) add pharmaceutically acceptable adjuvant in the mixed liquor of step, make ointment.
Embodiment 9: the preparation of ointment
Folium Artemisiae Argyi 45g, Herba Plantaginis 40g, Herba speranskiae tuberculatae 45g, Folium Mori 20g, Herba Portulacae 40g, Cortex Phellodendri 25g, Cortex Moutan 22g, Pericarpium Zanthoxyli 12g, Cortex Dictamni 24g, XIAKUQIU 18g, Radix Glycyrrhizae 8g, Herba Taraxaci 14g, Periostracum Cicadae 15g, Rhizoma Atractylodis 30g, Radix Scutellariae 4g, Flos Lonicerae 16g, Fructus Kochiae 14g, Semen Luffae 15g, Radix Sophorae Flavescentis 35g, Aloe 20g.
Preparation technology:
1) Radix Sophorae Flavescentis, Pericarpium Zanthoxyli are broken into fine powder and cross 80-100 mesh sieve;
2) by Folium Artemisiae Argyi, Herba Plantaginis, Herba speranskiae tuberculatae, Folium Mori, Herba Portulacae, Cortex Phellodendri, Cortex Moutan, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, Periostracum Cicadae, Rhizoma Atractylodis, Radix Scutellariae, Flos Lonicerae, the Fructus Kochiae, Semen Luffae, Aloe soak by water twice, each 2-4h, merge decoction liquor, filter, heating is concentrated, obtains concentrated solution;
3) by 1) fine powder and 2 of step) concentrated solution of step mixs homogeneously, and obtains mixed liquor;
4) to 3) add pharmaceutically acceptable adjuvant in the mixed liquor of step, make ointment.
Embodiment 10: the preparation of ointment
Folium Artemisiae Argyi 40g, Herba Plantaginis 25g, Herba speranskiae tuberculatae 35g, Folium Mori 18g, Herba Portulacae 37g, Cortex Phellodendri 22g, Cortex Moutan 20g, Pericarpium Zanthoxyli 10g, Cortex Dictamni 20g, XIAKUQIU 15g, Radix Glycyrrhizae 6g, Herba Taraxaci 12g, Periostracum Cicadae 12g, Rhizoma Atractylodis 24g, Radix Scutellariae 4g, Flos Lonicerae 16g, Fructus Kochiae 11g, Semen Luffae 11g, Radix Sophorae Flavescentis 30g, Aloe 17g.
Preparation technology:
1) Radix Sophorae Flavescentis, Pericarpium Zanthoxyli are broken into fine powder and cross 80-100 mesh sieve;
2) by Folium Artemisiae Argyi, Herba Plantaginis, Herba speranskiae tuberculatae, Folium Mori, Herba Portulacae, Cortex Phellodendri, Cortex Moutan, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, Periostracum Cicadae, Rhizoma Atractylodis, Radix Scutellariae, Flos Lonicerae, the Fructus Kochiae, Semen Luffae, Aloe soak by water twice, each 2-4h, merge decoction liquor, filter, heating is concentrated, obtains concentrated solution;
3) by 1) fine powder and 2 of step) concentrated solution of step mixs homogeneously, and obtains mixed liquor;
4) to 3) add pharmaceutically acceptable adjuvant in the mixed liquor of step, make ointment.
Embodiment 11: the clinical observation of this Chinese medicine preparation eczema of the embodiment of the present invention.
11.1, Therapeutic Method
One of the ointment of the one+embodiment 6-10 that the water decoction for the treatment of group: embodiment 1-5 is opened, water decoction is cooled to 35-45 DEG C, and washout affected part 10-20min, is then coated with appropriate ointment in affected part.Water decoction and ointment are 2 times every day, and 1 course for the treatment of is 10 days.
Matched group: use appropriate chlorhexidine gluconate ointment to smear affected part, be 2 every day, 1 course for the treatment of is 10 days.
11.2, efficacy assessment standard
Recovery from illness: eczema erythema disappears, and affected skin transfers to normally, kermesinus disappears.
Effective: eczema erythema obviously reduces, attack times reduces, and pruritus alleviates, and affected skin does not spread or diffusion velocity slows down.
Invalid: symptom does not disappear or increases the weight of.
Bounce-back: cure latter 3 months and run into hygrothermal environment and still show effect.
Effective percentage: (recovery from illness+take a turn for the better)/patient populations.
Rebound rate: (recovery from illness+take a turn for the better) recurrence/(recovery from illness+take a turn for the better)
11.3, experimental design
Adopt random, parallel control clinical trial design.Divide 2 groups at random by patient, accept the corresponding treatment of 20 days.Patient is assessed the clinical symptoms of patient and sign by same index evaluation person after the 20th day with treatment respectively before the treatment, and record in detail.Call-on back by phone was carried out to patient's situation of rebounding in 3rd month after treatment terminates.
11.4, disease overall therapeutic result
Choose between 2014-2015 first half of the year by the routine patient for the treatment of 57, patient age is in 0-5 year, mean age is within 2 years old, be probabilistically assigned to enter two groups, wherein treatment group 29 people, matched group 28 people, two groups of Genders, mean age, EASI are marked comparing difference not statistically significant (P>0.05), because of a variety of causes can not complete this test have 3 example, wherein treatment group 2 example, matched group 1 example.Detailed results is as table 1.
The situation of table 1 treatment group and treatment of control group and the recurrence after 3 months
As can be seen from Table 1, through the treatment of 20 days, treatment group compares with matched group total effective rate, has significant significant difference (P<0.01), and the effective percentage for the treatment of group is 100%, and the effective percentage of matched group is 85.2%; Treatment group, compared with matched group rebound rate, has significant significant difference (P<0.01), the rebound rate of matched group high nearly 63%, and western medicine has obvious dependency, and therapeutic effect is starkly lower than treatment group.
Embodiment 12: classical case
Case 1: Liu, female, 2 years old, the blue recluse in Shandong, 2012 are to our hospital, and it is too hot that father and mother react heating installation in family, minimal invasive treatment's environment is comparatively moist, and body parts has a large amount of blisters, pruritus flowing water, have difficulty in going to sleep, use the embodiment of the present invention 5 water decoction to wash affected part, and embodiment 7 ointment smear affected part, after 2 courses for the treatment of, symptom disappears completely, and call-on back by phone does not recur.
Case 2: poplar, man, 45 days, people from Linshu, Shandong, over 2014, I treats at institute, and there is a large amount of erythema patients head, ear clip both sides, night cry sits up, and use the embodiment of the present invention 2 water decoction to wash affected part, and embodiment 6 ointment smears affected part, the further consultation course for the treatment of, patient only has head to have a small amount of erythema, and sleep state is good, and after treating a course for the treatment of, return to one's perfect health, call-on back by phone does not recur.
Case 3: Hao, man, 1 years old, people from Chengdu, Sichuan, patient chest shoulders blister 5 months, pruritus flowing water, suppurate, certain institute's Dermatology Outpatient Department, examines as sensitivity dermatitis, through taking vitamin, the external application boric acid cloth that wets all does not obtain effect, and pruritus is immoderate, come my institute at the beginning of 2015 to check, wash affected part with the embodiment of the present invention 5 water decoction, and embodiment 10 ointment smears affected part, after 2 courses for the treatment of, symptom disappears completely, and call-on back by phone does not recur.
Case 3: grandson, man, 30 days, people from Fei County, Shandong, over 2013, I treats at institute, and patient has obvious infantile eczema, and face and skinfold portion, involve whole body, use the water decoction of the embodiment of the present invention 1 to treat two processes, return to one's perfect health, call-on back by phone does not recur.
Below know-why of the present invention is described in conjunction with specific embodiments.These describe just in order to explain principle of the present invention, and can not be interpreted as limiting the scope of the invention by any way.Based on explanation herein, those skilled in the art does not need to pay performing creative labour can associate other detailed description of the invention of the present invention, and these modes all will fall within protection scope of the present invention.
Claims (10)
1. treat the Chinese medicine composition of infantile eczema for one kind, it is characterized in that, be made up of the crude drug of following weight portion: Folium Artemisiae Argyi 30-50 part, Herba Plantaginis 10-30 part, Herba speranskiae tuberculatae 20-50 part, Folium Mori 10-30 part, Herba Portulacae 15-50 part, Cortex Phellodendri 10-30 part, Cortex Moutan 10-30 part, Pericarpium Zanthoxyli 5-25 part, Cortex Dictamni 10-30 part, XIAKUQIU 5-25 part, Radix Glycyrrhizae 4-8 part, Herba Taraxaci 10-15 part, Periostracum Cicadae 8-15 part, Rhizoma Atractylodis 20-30 part, Radix Scutellariae 2-6 part, Flos Lonicerae 5-20 part, Fructus Kochiae 8-14 part, Semen Luffae 10-25 part, Radix Sophorae Flavescentis 20-40 part, Aloe 10-25 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Folium Artemisiae Argyi 35-45 part, Herba Plantaginis 20-40 part, Herba speranskiae tuberculatae 25-45 part, Folium Mori 15-20 part, Herba Portulacae 35-40 part, Cortex Phellodendri 20-25 part, Cortex Moutan 18-22 part, Pericarpium Zanthoxyli 8-12 part, Cortex Dictamni 18-24 part, XIAKUQIU 13-18 part, Radix Glycyrrhizae 6-8 part, Herba Taraxaci 10-14 part, Periostracum Cicadae 12-15 part, Rhizoma Atractylodis 24-30 part, Radix Scutellariae 2-4 part, Flos Lonicerae 10-16 part, Fructus Kochiae 11-14 part, Semen Luffae 11-15 part, Radix Sophorae Flavescentis 25-35 part, Aloe 17-20 part.
3. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Folium Artemisiae Argyi 40 parts, Herba Plantaginis 25 parts, Herba speranskiae tuberculatae 35 parts, 18 parts, Folium Mori, Herba Portulacae 37 parts, Cortex Phellodendri 22 parts, Cortex Moutan 20 parts, 10 parts, Pericarpium Zanthoxyli, Cortex Dictamni 20 parts, XIAKUQIU 15 parts, 6 parts, Radix Glycyrrhizae, Herba Taraxaci 12 parts, Periostracum Cicadae 12 parts, Rhizoma Atractylodis 24 parts, Radix Scutellariae 4 parts, Flos Lonicerae 16 parts, the Fructus Kochiae 11 parts, Semen Luffae 11 parts, Radix Sophorae Flavescentis 30 parts, Aloe 17 parts.
4. prepare a preparation method for the Chinese medicine composition described in any one of claim 1-3, it is characterized in that, concrete step is:
1) Radix Sophorae Flavescentis, Pericarpium Zanthoxyli are broken into fine powder and cross 80-100 mesh sieve;
2) by Folium Artemisiae Argyi, Herba Plantaginis, Herba speranskiae tuberculatae, Folium Mori, Herba Portulacae, Cortex Phellodendri, Cortex Moutan, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, Periostracum Cicadae, Rhizoma Atractylodis, Radix Scutellariae, Flos Lonicerae, the Fructus Kochiae, Semen Luffae, Aloe soak by water twice, each 2-4h, merge decoction liquor, filter, heating is concentrated, obtains concentrated solution;
3) by 1) fine powder and 2 of step) concentrated solution of step mixs homogeneously, and obtains mixed liquor;
4) to 3) add pharmaceutically acceptable adjuvant in the mixed liquor of step, make ointment.
5. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: described ointment by weight part ratio be 1: 3.0-10.0 mixture and pharmaceutically acceptable adjuvant make.
6. the preparation method of Chinese medicine composition according to claim 5, is characterized in that: described ointment by weight part ratio be 1: 4.5-6.7 mixture and pharmaceutically acceptable adjuvant make.
7. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: described pharmaceutically acceptable adjuvant be selected from semi-synthetic fatty acid glyceride, Macrogol 4000, PEG400, Tween-80, polyoxyethylene, poloxamer, glycerin gelatine, glyceryl monostearate one or more.
8. the preparation method of Chinese medicine composition according to claim 7, is characterized in that: described pharmaceutically acceptable adjuvant is selected from the mixture of semi-synthetic fatty acid glyceride and glyceryl monostearate.
9. prepare a preparation method for Chinese medicine composition according to claim 1, it is characterized in that, concrete step can also be:
1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
2) crude drug of formula ratio is put into appropriate pure water, after fast fire is fried open, then decoct 30 minutes slowly, pour out decocting liquid.
10. Chinese medicine composition according to claim 1, is characterized in that: the application of described Chinese medicine composition in treatment infantile eczema.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535211A (en) * | 2016-01-18 | 2016-05-04 | 青岛辰达生物科技有限公司 | Medicinal preparation for treating infantile eczema and use of medicinal preparation |
| CN105770335A (en) * | 2016-03-21 | 2016-07-20 | 张艳娟 | Medicinal preparation for treating chronic eczema and application of medicinal preparation |
| CN105943588A (en) * | 2016-06-27 | 2016-09-21 | 杭州富阳伟文环保科技有限公司 | Ointment for treating infant eczema siccum |
| CN107582727A (en) * | 2017-11-09 | 2018-01-16 | 单县领翔金银花种植合作社 | A kind of medicine for treating childhood eczema and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474283A (en) * | 2009-01-22 | 2009-07-08 | 郑仰一 | Chinese medicine composition for treating eczema |
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2015
- 2015-10-15 CN CN201510665917.8A patent/CN105106488A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474283A (en) * | 2009-01-22 | 2009-07-08 | 郑仰一 | Chinese medicine composition for treating eczema |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535211A (en) * | 2016-01-18 | 2016-05-04 | 青岛辰达生物科技有限公司 | Medicinal preparation for treating infantile eczema and use of medicinal preparation |
| CN105770335A (en) * | 2016-03-21 | 2016-07-20 | 张艳娟 | Medicinal preparation for treating chronic eczema and application of medicinal preparation |
| CN105943588A (en) * | 2016-06-27 | 2016-09-21 | 杭州富阳伟文环保科技有限公司 | Ointment for treating infant eczema siccum |
| CN107582727A (en) * | 2017-11-09 | 2018-01-16 | 单县领翔金银花种植合作社 | A kind of medicine for treating childhood eczema and preparation method thereof |
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Application publication date: 20151202 |