CN105343523A - Medicine for treating lung cancer radiotherapy complication - Google Patents

Medicine for treating lung cancer radiotherapy complication Download PDF

Info

Publication number
CN105343523A
CN105343523A CN201510854995.2A CN201510854995A CN105343523A CN 105343523 A CN105343523 A CN 105343523A CN 201510854995 A CN201510854995 A CN 201510854995A CN 105343523 A CN105343523 A CN 105343523A
Authority
CN
China
Prior art keywords
weight portion
radix
chinese medicine
herba
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510854995.2A
Other languages
Chinese (zh)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SU ZHAOZHEN
Original Assignee
SU ZHAOZHEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SU ZHAOZHEN filed Critical SU ZHAOZHEN
Priority to CN201510854995.2A priority Critical patent/CN105343523A/en
Publication of CN105343523A publication Critical patent/CN105343523A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention provides a traditional Chinese medicine composition for treating lung cancer radiotherapy complication. The traditional Chinese medicine composition is prepared from prepared rehmannia roots, asparagus cochinchinensis, radix paeoniae alba, platycodon grandiflorum, cordyceps sinensis, bulbus fritillariae cirrhosae, glabrous sarcandra herbs, eclipta, dogwood, folium eriobotryae, vines of multiflower knotweed, radix scrophulariae, honeysuckle, scutellaria baicalensis, liquorice, rhizoma polygonati, American ginseng, rice galingale herbs, talinum crassifolium, pinellia ternate, chimonanthus nitens and peacock tail. The traditional Chinese medicine composition has definite functions of resisting to lung cancer radiotherapy complication, whole-body centralization is considered, and immunity is enhanced, so that recurrence and metastasis of tumor are reduced and delayed, more superiority is achieved compared with traditional hormonotherapy, after the traditional Chinese medicine is adopted to treat lung cancer radiotherapy complication, the traditional Chinese medicine composition has great advantages, the curative effect is remarkable, the side effect is little, the life quality of a patient can be improved, and the traditional Chinese medicine composition is worthy of clinic application and popularization.

Description

A kind of medicine for the treatment of lung tumors irradiation complication
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of medicine being used for the treatment of lung tumors irradiation complication.
Background technology
In worldwide, sickness rate, the case fatality rate of pulmonary carcinoma rise year by year.According to statistics, the whole world has 1,200,000 new cases every year, accounts for 12.1% of cancer total incidence.In cancer mortality case, pulmonary carcinoma accounts for 16.9%, and year dead 91.8 ten thousand is routine, and epidemic diseases scholarly forecast pulmonary carcinoma has become one of 21 century most commonly encountered diseases.Pulmonary carcinoma case fatality rate is very high, and its serious threat is to the health and lives of people, and the patient because of 70%, finding to be in middle and advanced stage when falling ill, has at this moment missed best opportunity of operation, so should adopt the Comprehensive Treatment based on radiotherapy.But lungs belong to radiation-sensitive organ, the generation often with lung tumors irradiation complication in radiotherapy in lung cancer process, the phase there will be radiation fibrosis of lung especially after the treatment, finally causes death.
Its incidence rate of lung tumors irradiation complication reaches 13% ~ 37%, finally develops into radiation fibrosis of lung, has a strong impact on radiotherapy and the life quality of patient.The cardinal symptom of lung tumors irradiation complication is that zest dry cough, uncomfortable in chest, chest pain, breathing are out of breath or with low grade fever etc.Its clinical symptoms have more present radiotherapy start after 1 ~ 3 month.
At present, both at home and abroad still without the Therapeutic Method of lung tumors irradiation complication safely and effectively, adopt adrenocortical hormone combined with antibiotic to be aided with oxygen uptake more clinically, relieving asthma, cough-relieving etc. supports process to the ill, but erious adverse reaction, and easily cause superinfection, dysbacteriosis, immunosuppressant etc., although and use glucocorticoid, allow the development so having the patient of considerable part effectively can not control injury of lung, final progress be pulmonary fibrosis.
Chinese medicine thinks that lonizing radiation are the heresy of pyretic toxicity, pyretic toxicity impairing the lung, the most easily consumes impairment of QI cloudy, and with the passing of time refine liquid and become expectorant to become the stasis of blood, phlegm and blood stasis, impaired depurative descending of lung QI falls, then see above-mentioned symptom.Clinical manifestation is immunologic function degression, bone marrow depression, tissue fibering.A lot of research shows that Traditional Chinese Medicine is embodying good effect in the preventing and treating of induced lung injury, and the advantage that toxic side effect is low.Meanwhile, the Overall View of Chinese medicine, more holistic is nursed one's health, and improves immune function of human body, protection hemopoietic system, thus improves life quality.
Based on this, the invention provides a kind of Chinese medicine composition being used for the treatment of lung tumors irradiation complication, it has significant curative effect in treatment lung tumors irradiation complication.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition endo-medicine being used for the treatment of lung tumors irradiation complication, it not only has the effect of definite resisting tumor of lung irradiation complication, and whole body righting can be taken into account, strengthen immunity, thus reduce and delay recurrence and the transfer of tumor, more traditional hormone therapy has more superiority, treatment by Chinese herbs primary disease is adopted to have larger advantage, evident in efficacy, side effect is little, and the life quality of patient can be improved, be worth using at clinical expansion.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition being used for the treatment of lung tumors irradiation complication, its crude drug comprises: Radix Rehmanniae Preparata, Radix Asparagi, the Radix Paeoniae Alba, Radix Platycodonis, Cordyceps, Bulbus Fritillariae Cirrhosae, Herba Sarcandrae, Herba Ecliptae, Fructus Corni, Folium Eriobotryae, Caulis Polygoni Multiflori, Radix Scrophulariae, Flos Lonicerae, Radix Scutellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Radix Panacis Quinquefolii, Herba Cyperi Iriae, Radix Talini Paniculati, the Rhizoma Pinelliae, Chimonanthus Nitens and Herba Asplenii Sarelii.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 20 weight portion ~ 30 weight portion, Radix Asparagi 30 weight portion ~ 40 weight portion, the Radix Paeoniae Alba 25 weight portion ~ 35 weight portion, Radix Platycodonis 15 weight portion ~ 25 weight portion, Cordyceps 30 weight portion ~ 40 weight portion, Bulbus Fritillariae Cirrhosae 20 weight portion ~ 30 weight portion, Herba Sarcandrae 15 weight portion ~ 25 weight portion, Herba Ecliptae 20 weight portion ~ 30 weight portion, Fructus Corni 30 weight portion ~ 40 weight portion, Folium Eriobotryae 15 weight portion ~ 25 weight portion, Caulis Polygoni Multiflori 25 weight portion ~ 35 weight portion, Radix Scrophulariae 20 weight portion ~ 30 weight portion, Flos Lonicerae 30 weight portion ~ 40 weight portion, Radix Scutellariae 25 weight portion ~ 35 weight portion, Radix Glycyrrhizae 15 weight portion ~ 25 weight portion, Rhizoma Polygonati 30 weight portion ~ 40 weight portion, Radix Panacis Quinquefolii 40 weight portion ~ 50 weight portion, Herba Cyperi Iriae 20 weight portion ~ 30 weight portion, Radix Talini Paniculati 25 weight portion ~ 35 weight portion, the Rhizoma Pinelliae 20 weight portion ~ 30 weight portion, Chimonanthus Nitens 10 weight portion ~ 20 weight portion and Herba Asplenii Sarelii 10 weight portion ~ 20 weight portion.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 23 weight portion ~ 27 weight portion, Radix Asparagi 33 weight portion ~ 37 weight portion, the Radix Paeoniae Alba 28 weight portion ~ 32 weight portion, Radix Platycodonis 18 weight portion ~ 22 weight portion, Cordyceps 33 weight portion ~ 37 weight portion, Bulbus Fritillariae Cirrhosae 23 weight portion ~ 27 weight portion, Herba Sarcandrae 18 weight portion ~ 22 weight portion, Herba Ecliptae 23 weight portion ~ 27 weight portion, Fructus Corni 33 weight portion ~ 37 weight portion, Folium Eriobotryae 18 weight portion ~ 22 weight portion, Caulis Polygoni Multiflori 28 weight portion ~ 32 weight portion, Radix Scrophulariae 23 weight portion ~ 27 weight portion, Flos Lonicerae 33 weight portion ~ 37 weight portion, Radix Scutellariae 28 weight portion ~ 32 weight portion, Radix Glycyrrhizae 18 weight portion ~ 22 weight portion, Rhizoma Polygonati 33 weight portion ~ 37 weight portion, Radix Panacis Quinquefolii 43 weight portion ~ 47 weight portion, Herba Cyperi Iriae 23 weight portion ~ 27 weight portion, Radix Talini Paniculati 28 weight portion ~ 32 weight portion, the Rhizoma Pinelliae 23 weight portion ~ 27 weight portion, Chimonanthus Nitens 13 weight portion ~ 17 weight portion and Herba Asplenii Sarelii 13 weight portion ~ 17 weight portion.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 25 weight portion, Radix Asparagi 35 weight portion, the Radix Paeoniae Alba 30 weight portion, Radix Platycodonis 20 weight portion, Cordyceps 35 weight portion, Bulbus Fritillariae Cirrhosae 25 weight portion, Herba Sarcandrae 20 weight portion, Herba Ecliptae 25 weight portion, Fructus Corni 35 weight portion, Folium Eriobotryae 20 weight portion, Caulis Polygoni Multiflori 30 weight portion, Radix Scrophulariae 25 weight portion, Flos Lonicerae 35 weight portion, Radix Scutellariae 30 weight portion, Radix Glycyrrhizae 20 weight portion, Rhizoma Polygonati 35 weight portion, Radix Panacis Quinquefolii 45 weight portion, Herba Cyperi Iriae 25 weight portion, Radix Talini Paniculati 30 weight portion, the Rhizoma Pinelliae 25 weight portion, Chimonanthus Nitens 15 weight portion and Herba Asplenii Sarelii 15 weight portion.
Wherein, described Chinese medicine composition can take orally, also can external.
Wherein, described Chinese medicine composition is as being oral liquid during endo-medicine, and described Chinese medicine composition is as during external used medicine being spraying decoction.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is prepared into oral liquid, be specially:
The first step, described component is mixed in proportion, be placed in super micron mill and pulverize 20 minutes ~ 40 minutes, it is in the ethanol of 80% ~ 90% that mixture after pulverizing is dissolved in determining alcohol, reflux, extract, 2 times ~ 4 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtain dry mastic, wherein, the amount of the ethanol added is 2 ~ 4 times of first step mixture quality, carry out drying subsequently, 20 minutes ~ 40 minutes are pulverized with super micron mill, powder after pulverizing is added the water dissolution relative to its quality 3 ~ 5 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,
Second step, in the powder that the first step obtains, add the distilled water relative to its quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is prepared into spraying decoction, be specially:
By described each crude drug by above-mentioned weight mixing, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decocts 2 ~ 4 hours, and decoction liquor is filtered, twice decoction liquor is merged, obtains spraying decoction.
Present invention also offers the using method of above-mentioned spraying decoction, be specially:
Add in the medicine glass of nebulizer by spraying decoction, gas source conduit interface end Bonding pressure oxygen source or socket end are connected socket bottom respiration bottle, respiration bottle top on demand connector, containing device or face shield, passes into tolerance >=5L/min, carries out Neulized inhalation.
Beneficial effect of the present invention:
The Chinese medicine composition being used for the treatment of lung tumors irradiation complication provided by the invention, not only there is the effect of definite resisting tumor of lung irradiation complication, and whole body righting can be taken into account, strengthen immunity, thus reduce and delay recurrence and the transfer of tumor, more traditional hormone therapy has more superiority, adopt treatment by Chinese herbs primary disease to have larger advantage, evident in efficacy, side effect is little, and the life quality of patient can be improved, be worth using at clinical expansion.
Detailed description of the invention
We are according to tcm theory, lonizing radiation surely belong to " heresy of pyretic toxicity ", because it has isotonicity, different from the heresy of general pyretic toxicity, do not follow " defensive-qi-nutrient-blood " change of disease rule, but through lungs, radiotherapy patient is prolonged and repeated accepts radiation exposure, the heresy of pyretic toxicity is attacked repeatedly, damage of pulmonary collateral occurs repeatedly, with the passing of time pyretic toxicity retardance is then become, lung network stasis blocking, pathological changes will increase the weight of day by day, final lung Folium piperis betlis is burnt, lose it to breathe, declare respectful duty, this understanding conforms to modern times pathological discovery, we think that primary disease treatment should with non-specific antiinflammatory, dredging microcirculation, anticoagulant, fibrosis is policy, application activating blood and removing stasis Method can have obvious scavenging free radicals and lipoid peroxidization resistant, reduce its damage to irradiation in all of pulmonary parenchyma cells, the effect that oxygen-derived free radicals stimulates fibroblast proliferation can be reduced simultaneously, and can microcirculation be improved, protection vascular endothelial cell, reduce vascular resistance, increase blood flow, blood vessel dilating, lower vascular permeability, make Oxygen deliver, oxygen consumption increases, oxygen uptake rate reduces, alleviating vascular pathological changes, anticoagulant, reduce blood viscosity, the height improving blood glues, hypercoagulability, improve the hypoxia-bearing capability of body, thus reduce inflammation, collagen fiber are suppressed to generate, this can improve the immunologic function of body, increase patient to the toleration of radiotherapy, improve the quality of life of patient, all there is significant curative effect the life cycle extending patient.
The invention provides a kind of Chinese medicine composition being used for the treatment of lung tumors irradiation complication, its crude drug comprises: Radix Rehmanniae Preparata, Radix Asparagi, the Radix Paeoniae Alba, Radix Platycodonis, Cordyceps, Bulbus Fritillariae Cirrhosae, Herba Sarcandrae, Herba Ecliptae, Fructus Corni, Folium Eriobotryae, Caulis Polygoni Multiflori, Radix Scrophulariae, Flos Lonicerae, Radix Scutellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Radix Panacis Quinquefolii, Herba Cyperi Iriae, Radix Talini Paniculati, Caulis et folium cryptotaeniae japonicae, Rhizoma Fagopyri Dibotryis, Chimonanthus Nitens and Herba Asplenii Sarelii.
Further, described Chinese medicine composition is only made up of above-mentioned raw materials medicine.
Fang Zhong, Radix Rehmanniae Preparata, Radix Asparagi, Herba Ecliptae nourishing YIN and moistening the lung promotes the production of body fluid, Radix Paeoniae Alba blood circulation promoting and blood stasis dispelling, nourishing blood to suppress the hyperactive liver, lung qi dispersing gas opened by Radix Platycodonis, strengthen the power of cough-relieving, Bulbus Fritillariae Cirrhosae nourishing the lung to arrest cough, resolving phlegm and relieving asthma, Herba Sarcandrae heat-clearing and toxic substances removing, Fructus Corni, Cordyceps liver and kidney tonifying, regulate body resistance against diseases, Folium Eriobotryae nourishing the lung to arrest cough, Radix Ginseng has antioxidation and effect of scavenging radical, thus the peroxide injury that minimizing ray causes, be reduced to fibrocellular hypertrophy, the Radix Paeoniae Alba, Caulis Polygoni Multiflori has protection vascular endothelial cell, improve blood circulation, alleviating vascular spasm, anticoagulant is done, all medicines share, play replenishing YIN and removing heat altogether, nourishing the lung to arrest cough, the merit of blood circulation promoting and blood stasis dispelling, Radix Scrophulariae can weaken the Chemotaxis Function of inflammatory mediator, reduce inflammation reaction, and there is stronger antioxidation, in the process that can reduce inflammation, reactive oxygen species material is to the damage of tissue, there is antitumor simultaneously, the function of enhancing immunity, Flos Lonicerae, Radix Scutellariae has obvious antiinflammatory action, the permeability of blood capillary can be reduced, reduce inflammatory exudation, and the phagocytic activity of inflammatory exudation cell can be strengthened, thus the anti-defensive enginery of enhancing body, Radix Glycyrrhizae has QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, Rhizoma Polygonati nourishing YIN and moistening the lung, Radix Panacis Quinquefolii boosting qi and nourishing yin, relieve inflammation or internal heat and promote the production of body fluid, Herba Cyperi Iriae activating QI to alleviate the depression, dispelling wind for relieving itching, Radix Talini Paniculati's heat-clearing and toxic substances removing, tonify deficiency cough-relieving, Caulis et folium cryptotaeniae japonicae dispelling wind stopping cough, eliminating damp, detoxifying, Rhizoma Fagopyri Dibotryis heat-clearing and toxic substances removing, evacuation of pus blood stasis dispelling, Chimonanthus Nitens expelling pathogenic wind from the body surface, removing dampness by means of aromatics, Herba Asplenii Sarelii heat-clearing and toxic substances removing, hemostasia and promoting granulation, all medicines share, play replenishing YIN and removing heat altogether, nourishing the lung to arrest cough, the merit of blood circulation promoting and blood stasis dispelling.
The pharmacology of each crude drug is as follows:
Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature, enters liver, kidney channel, has YIN nourishing of enriching blood, and beneficial essence fills out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney the cards such as dyspnea with rapid and short breath.
Radix Asparagi: sweet in the mouth, hardship, cold in nature, return lung, kidney channel, there is nourishing YIN to relieve dryness, effect that lung heat clearing is promoted the production of body fluid, cures mainly cough caused by dryness-heat, deficiency of YIN chronic cough, hyperactivity of fire caused by deficiency of YIN, the laryngopharynx swelling and pain of the not solid seminal emission of kidney essense, premature ejaculation and hyperactivity of deficient fire, calentura Tianjin wound is thirsty, and interior-heat is quenched one's thirst the cards such as dryness of the intestine constipation.
The Radix Paeoniae Alba: latin name PaeoniaeRadixAlba, bitter in the mouth, acid, cool in nature, enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior card.
Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature, enters lung meridian, has effect of expelling phlegm for arresting cough, lung qi dispersing evacuation of pus, cures mainly the cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Cordyceps: sweet in the mouth, property is put down, and enters lung, kidney channel, have kidney invigorating and YANG supporting, tonifying the lung is relievingd asthma, effect of hemostasis and phlegm, the traditional Chinese medical science is thought, Cordyceps enters lung kidney two warp, can tonifying the lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint, weak after being ill, chronic cough is weak, phthisical cough expectorant blood, spontaneous sweating etc. are unique a kind of Chinese medicine compositions that can balance simultaneously, regulate negative and positive.
Bulbus Fritillariae Cirrhosae: bitter in the mouth, sweet, cold nature, returns lung, heart channel, has clearing heat and moistening lung, effect of preventing phlegm from forming and stopping coughing, for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, sore throat, the card such as acute mastitis.
Herba Sarcandrae: bitter in the mouth, sweet, cold nature, returns lung, heart channel, has clearing heat and moistening lung, effect of preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, the card such as sputum with blood, cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, sore throat, acute mastitis.
Herba Ecliptae: have another name called Herba Ecliptae, ink grass, floods and droughts lotus, sweet in the mouth, acid, cold in nature, return liver, kidney channel, play not liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell caused by the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Be suitable for the deficiency of YIN and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the symptoms such as the hemoptysis of injury of blood vessel of the lung by heat, Herba Ecliptae has inhibitory action to staphylococcus aureus, Bacillus typhi, S. sonnei, bacillus pyocyaneus, can obvious enhancing non-specific immunity and cellular immune function.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has liver and kidney tonifying, effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat such as to be quenched one's thirst at the card.
Folium Eriobotryae: bitter in the mouth, cold nature, returns lung, stomach warp, has clearing away lung-heat to relieve cough, effect of stopping nausea and vomiting by lowering the adverse flow of QI, this product bitter cold, energy clearing away lung-heat, falls lung qi with cough-relieving, be usually used in treatment cough due to lung-heat, abundant expectoration yellow skin, can fall gastric qi and preventing or arresting vomiting is inverse, for the vomiting that gastric heat causes, treatment xerostomia is quenched one's thirst, lung-wind syndrome acne vulgaris, acne.
Caulis Polygoni Multiflori: sweet in the mouth, property is put down, and GUIXIN, Liver Channel, have nourishing blood to tranquillize the mind, and effect of dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; The cards such as skin pruritus, Caulis Polygoni Multiflori can be invigorated blood circulation, stimulate the menstrual flow, the detumescence of blood vessel dilating, blood circulation promoting, stimulating milk secretion.
Radix Scrophulariae: sweet in the mouth, hardship, one-tenth, cold nature, returns lung, stomach, kidney channel, have clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing supports effect of kidney, cure mainly pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Flos Lonicerae: sweet in the mouth, cold in nature, enters the heart, lung, stomach, large intestine channel, has the effect of heat-clearing and toxic substances removing, and holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is comparatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer is demonstrate,proved; The carbuncle sore that pyretic toxicity gathers is from the beginning of the, inflammation heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, leukocytic phagocytic function can be promoted, there is stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, newcastle, bacillus pyocyaneus, tubercule bacillus etc.
Radix Scutellariae: latin name ScutellariaeRadix, bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, is mainly used in damp and hot caused diarrhoea, dysentery, jaundice, pyretic stranguria; Cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and pyretic toxicity pathogenic fire invades the swollen card of carbuncle sore poison of excessive skin.
Radix Glycyrrhizae: property is put down, sweet in the mouth, enters 12 warps, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription, for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse and deficiency of spleen-QI and stomach-QI, fatigue and weakness, ulcer sores, laryngopharynx swelling and pain, asthma and cough, is in harmonious proportion some drugs strong.
Rhizoma Polygonati: latin name PolygonatiRhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Radix Panacis Quinquefolii: sweet in the mouth, micro-hardship, cool in nature, GUIXIN, lung, kidney channel, have boosting qi and nourishing yin, effect of clearing away heat and promoting production of body fluid, and cure mainly deficiency of vital energy the moon and lose, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.
Herba Cyperi Iriae: bitter in the mouth; Pungent; Cool in nature, liver; Lung meridian, has activating QI to alleviate the depression; Dispelling wind for relieving itching; Effect of wide born of the same parents profit expectorant, cures mainly and uncomfortable in chestly not to relax; Rubella pruritus; Carbuncle is with cards such as toxic swellings.
Radix Talini Paniculati: latin name PedicularismuscicolaMaxim, sweet in the mouth, micro-hardship, tool heat-clearing toxin-expelling functions, weak to the deficiency of vital energy, diarrhea due to hypofunction of the spleen, xeropulmonary cough, neurasthenia etc. have certain curative effect.Strongly invigorating primordial QI, promoting the production of body fluid and inducing sedation of the mind, heart tonifying.Control QI and blood deficient, asthenia hyperhidrosis, collapse exhaustion, blood pressure reduces.
Chimonanthus Nitens: acrid in the mouth, micro-hardship, warm in nature, there is expelling pathogenic wind from the body surface, removing dampness by means of aromatics, cure mainly influenza, heatstroke, chronic bronchitis, wet tired uncomfortable in chest, the cards such as mosquito bite.
Herba Asplenii Sarelii: bitter in the mouth, micro-sweet, cool in nature, have heat-clearing and toxic substances removing, effect of hemostasia and promoting granulation, cures mainly influenza, conjunctival congestion and swelling pain, tonsillitis, cough, jaundice, enteritis, dysentery, gastrointestinal haemorrhagia, traumatic injury, the cards such as burn and scald.
In described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 20 weight portion ~ 30 weight portion, Radix Asparagi 30 weight portion ~ 40 weight portion, the Radix Paeoniae Alba 25 weight portion ~ 35 weight portion, Radix Platycodonis 15 weight portion ~ 25 weight portion, Cordyceps 30 weight portion ~ 40 weight portion, Bulbus Fritillariae Cirrhosae 20 weight portion ~ 30 weight portion, Herba Sarcandrae 15 weight portion ~ 25 weight portion, Herba Ecliptae 20 weight portion ~ 30 weight portion, Fructus Corni 30 weight portion ~ 40 weight portion, Folium Eriobotryae 15 weight portion ~ 25 weight portion, Caulis Polygoni Multiflori 25 weight portion ~ 35 weight portion, Radix Scrophulariae 20 weight portion ~ 30 weight portion, Flos Lonicerae 30 weight portion ~ 40 weight portion, Radix Scutellariae 25 weight portion ~ 35 weight portion, Radix Glycyrrhizae 15 weight portion ~ 25 weight portion, Rhizoma Polygonati 30 weight portion ~ 40 weight portion, Radix Panacis Quinquefolii 40 weight portion ~ 50 weight portion, Herba Cyperi Iriae 20 weight portion ~ 30 weight portion, Radix Talini Paniculati 25 weight portion ~ 35 weight portion, the Rhizoma Pinelliae 20 weight portion ~ 30 weight portion, Chimonanthus Nitens 10 weight portion ~ 20 weight portion and Herba Asplenii Sarelii 10 weight portion ~ 20 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 23 weight portion ~ 27 weight portion, Radix Asparagi 33 weight portion ~ 37 weight portion, the Radix Paeoniae Alba 28 weight portion ~ 32 weight portion, Radix Platycodonis 18 weight portion ~ 22 weight portion, Cordyceps 33 weight portion ~ 37 weight portion, Bulbus Fritillariae Cirrhosae 23 weight portion ~ 27 weight portion, Herba Sarcandrae 18 weight portion ~ 22 weight portion, Herba Ecliptae 23 weight portion ~ 27 weight portion, Fructus Corni 33 weight portion ~ 37 weight portion, Folium Eriobotryae 18 weight portion ~ 22 weight portion, Caulis Polygoni Multiflori 28 weight portion ~ 32 weight portion, Radix Scrophulariae 23 weight portion ~ 27 weight portion, Flos Lonicerae 33 weight portion ~ 37 weight portion, Radix Scutellariae 28 weight portion ~ 32 weight portion, Radix Glycyrrhizae 18 weight portion ~ 22 weight portion, Rhizoma Polygonati 33 weight portion ~ 37 weight portion, Radix Panacis Quinquefolii 43 weight portion ~ 47 weight portion, Herba Cyperi Iriae 23 weight portion ~ 27 weight portion, Radix Talini Paniculati 28 weight portion ~ 32 weight portion, the Rhizoma Pinelliae 23 weight portion ~ 27 weight portion, Chimonanthus Nitens 13 weight portion ~ 17 weight portion and Herba Asplenii Sarelii 13 weight portion ~ 17 weight portion.
Further preferred, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 25 weight portion, Radix Asparagi 35 weight portion, the Radix Paeoniae Alba 30 weight portion, Radix Platycodonis 20 weight portion, Cordyceps 35 weight portion, Bulbus Fritillariae Cirrhosae 25 weight portion, Herba Sarcandrae 20 weight portion, Herba Ecliptae 25 weight portion, Fructus Corni 35 weight portion, Folium Eriobotryae 20 weight portion, Caulis Polygoni Multiflori 30 weight portion, Radix Scrophulariae 25 weight portion, Flos Lonicerae 35 weight portion, Radix Scutellariae 30 weight portion, Radix Glycyrrhizae 20 weight portion, Rhizoma Polygonati 35 weight portion, Radix Panacis Quinquefolii 45 weight portion, Herba Cyperi Iriae 25 weight portion, Radix Talini Paniculati 30 weight portion, the Rhizoma Pinelliae 25 weight portion, , Chimonanthus Nitens 15 weight portion and Herba Asplenii Sarelii 15 weight portion.
Chinese medicine composition provided by the invention can take orally, also can external, and preferably for oral administration and external uses simultaneously, and endo-medicine is prepared into oral liquid, and external used medicine is prepared into spraying decoction.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is prepared into oral liquid, be specially:
The first step, described component is mixed in proportion, be placed in super micron mill and pulverize 20 minutes ~ 40 minutes, it is in the ethanol of 80% ~ 90% that mixture after pulverizing is dissolved in determining alcohol, reflux, extract, 2 times ~ 4 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtain dry mastic, wherein, the amount of the ethanol added is 2 ~ 4 times of first step mixture quality, carry out drying subsequently, 20 minutes ~ 40 minutes are pulverized with super micron mill, powder after pulverizing is added the water dissolution relative to its quality 3 ~ 5 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,
Second step, in the powder that the first step obtains, add the distilled water relative to its quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is prepared into spraying decoction, be specially:
By described each crude drug by above-mentioned weight mixing, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decocts 2 ~ 4 hours, and decoction liquor is filtered, twice decoction liquor is merged, obtains spraying decoction.
Present invention also offers the using method of above-mentioned spraying decoction, be specially:
Add in the medicine glass of nebulizer by spraying decoction, gas source conduit interface end Bonding pressure oxygen source or socket end are connected socket bottom respiration bottle, respiration bottle top on demand connector, containing device or face shield, passes into tolerance >=5L/min, carries out Neulized inhalation.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 oral liquid 1
By Radix Rehmanniae Preparata 25g, Radix Asparagi 35g, Radix Paeoniae Alba 30g, Radix Platycodonis 20g, Cordyceps 35g, Bulbus Fritillariae Cirrhosae 25g, Herba Sarcandrae 20g, Herba Ecliptae 25g, Fructus Corni 35g, Folium Eriobotryae 20g, Caulis Polygoni Multiflori 30g, Radix Scrophulariae 25g, Flos Lonicerae 35g, Radix Scutellariae 30g, Radix Glycyrrhizae 20g, Rhizoma Polygonati 35g, Radix Panacis Quinquefolii 45g, Herba Cyperi Iriae 25g, Radix Talini Paniculati 30g, Rhizoma Pinelliae 25g, Chimonanthus Nitens 15g and Herba Asplenii Sarelii 15g mixes, and is placed in super micron mill and pulverizes 30 minutes, is in the ethanol of 90% by the determining alcohol that the mixture after pulverizing is dissolved in 1.8kg, reflux, extract, 3 times, filters, merging filtrate, concentrating under reduced pressure removing ethanol, obtains dry mastic, carries out drying subsequently, pulverize 30 minutes with super micron mill, the powder after pulverizing is added the water dissolution relative to its quality 3 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object fine powders subsequently, get the powder that 50g obtains, add the distilled water of 200g, 10g sucrose, 1g sodium benzoate, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid 1.
The preparation of embodiment 2 oral liquid 2
By Radix Rehmanniae Preparata 23g, Radix Asparagi 33g, Radix Paeoniae Alba 28g, Radix Platycodonis 18g, Cordyceps 33g, Bulbus Fritillariae Cirrhosae 23g, Herba Sarcandrae 18g, Herba Ecliptae 23g, Fructus Corni 33g, Folium Eriobotryae 18g, Caulis Polygoni Multiflori 28g, Radix Scrophulariae 23g, Flos Lonicerae 33g, Radix Scutellariae 28g, Radix Glycyrrhizae 18g, Rhizoma Polygonati 33g, Radix Panacis Quinquefolii 43g, Herba Cyperi Iriae 23g, Radix Talini Paniculati 28g, Rhizoma Pinelliae 23g, Chimonanthus Nitens 13g and Herba Asplenii Sarelii 13g mixes, and is placed in super micron mill and pulverizes 30 minutes, is in the ethanol of 90% by the determining alcohol that the mixture after pulverizing is dissolved in 1.5kg, reflux, extract, 3 times, filters, merging filtrate, concentrating under reduced pressure removing ethanol, obtains dry mastic, carries out drying subsequently, pulverize 30 minutes with super micron mill, the powder after pulverizing is added the water dissolution relative to its quality 3 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object fine powders subsequently, get the powder that 50g obtains, add the distilled water of 200g, 10g sucrose, 1g sodium benzoate, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid 2.
The preparation of embodiment 3 oral liquid 3
By Radix Rehmanniae Preparata 27g, Radix Asparagi 37g, Radix Paeoniae Alba 32g, Radix Platycodonis 22g, Cordyceps 37g, Bulbus Fritillariae Cirrhosae 27g, Herba Sarcandrae 22g, Herba Ecliptae 27g, Fructus Corni 37g, Folium Eriobotryae 22g, Caulis Polygoni Multiflori 32g, Radix Scrophulariae 27g, Flos Lonicerae 37g, Radix Scutellariae 32g, Radix Glycyrrhizae 22g, Rhizoma Polygonati 37g, Radix Panacis Quinquefolii 47g, Herba Cyperi Iriae 27g, Radix Talini Paniculati 32g, Rhizoma Pinelliae 27g, Chimonanthus Nitens 17g and Herba Asplenii Sarelii 17g mixes, and is placed in super micron mill and pulverizes 30 minutes, is in the ethanol of 90% by the determining alcohol that the mixture after pulverizing is dissolved in 2kg, reflux, extract, 3 times, filters, merging filtrate, concentrating under reduced pressure removing ethanol, obtains dry mastic, carries out drying subsequently, pulverize 30 minutes with super micron mill, the powder after pulverizing is added the water dissolution relative to its quality 3 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object fine powders subsequently, get the powder that 50g obtains, add the distilled water of 200g, 10g sucrose, 1g sodium benzoate, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid 3.
Embodiment 4 is sprayed decoction 1
By Radix Rehmanniae Preparata 25g, Radix Asparagi 35g, Radix Paeoniae Alba 30g, Radix Platycodonis 20g, Cordyceps 35g, Bulbus Fritillariae Cirrhosae 25g, Herba Sarcandrae 20g, Herba Ecliptae 25g, Fructus Corni 35g, Folium Eriobotryae 20g, Caulis Polygoni Multiflori 30g, Radix Scrophulariae 25g, Flos Lonicerae 35g, Radix Scutellariae 30g, Radix Glycyrrhizae 20g, Rhizoma Polygonati 35g, Radix Panacis Quinquefolii 45g, Herba Cyperi Iriae 25g, Radix Talini Paniculati 30g, Rhizoma Pinelliae 25g, Chimonanthus Nitens 15g and Herba Asplenii Sarelii 15g mixes, add the water of 1.8kg, decoct 5 hours, decoction liquor is filtered, filtering residue adds the water of 1.2kg again, decoct 4 hours, decoction liquor is filtered, twice decoction liquor is merged, obtain spraying decoction 1.
Embodiment 5 is sprayed decoction 2
Radix Rehmanniae Preparata 23g, Radix Asparagi 33g, Radix Paeoniae Alba 28g, Radix Platycodonis 18g, Cordyceps 33g, Bulbus Fritillariae Cirrhosae 23g, Herba Sarcandrae 18g, Herba Ecliptae 23g, Fructus Corni 33g, Folium Eriobotryae 18g, Caulis Polygoni Multiflori 28g, Radix Scrophulariae 23g, Flos Lonicerae 33g, Radix Scutellariae 28g, Radix Glycyrrhizae 18g, Rhizoma Polygonati 33g, Radix Panacis Quinquefolii 43g, Herba Cyperi Iriae 23g, Radix Talini Paniculati 28g, Rhizoma Pinelliae 23g, Chimonanthus Nitens 13g and Herba Asplenii Sarelii 13g are mixed, add the water of 1.6kg, decoct 5 hours, decoction liquor is filtered, filtering residue adds the water of 1kg again, decoct 4 hours, decoction liquor is filtered, twice decoction liquor is merged, obtains spraying decoction 2.
Embodiment 6 is sprayed decoction 3
Radix Rehmanniae Preparata 27g, Radix Asparagi 37g, Radix Paeoniae Alba 32g, Radix Platycodonis 22g, Cordyceps 37g, Bulbus Fritillariae Cirrhosae 27g, Herba Sarcandrae 22g, Herba Ecliptae 27g, Fructus Corni 37g, Folium Eriobotryae 22g, Caulis Polygoni Multiflori 32g, Radix Scrophulariae 27g, Flos Lonicerae 37g, Radix Scutellariae 32g, Radix Glycyrrhizae 22g, Rhizoma Polygonati 37g, Radix Panacis Quinquefolii 47g, Herba Cyperi Iriae 27g, Radix Talini Paniculati 32g, Rhizoma Pinelliae 27g, Chimonanthus Nitens 17g and Herba Asplenii Sarelii 17g are mixed, add the water of 2kg, decoct 5 hours, decoction liquor is filtered, filtering residue adds the water of 1.5kg again, decoct 4 hours, decoction liquor is filtered, twice decoction liquor is merged, obtains spraying decoction 3.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (4)

1. be used for the treatment of a Chinese medicine composition for lung tumors irradiation complication, it is characterized in that: the crude drug of described Chinese medicine composition comprises Radix Rehmanniae Preparata, Radix Asparagi, the Radix Paeoniae Alba, Radix Platycodonis, Cordyceps, Bulbus Fritillariae Cirrhosae, Herba Sarcandrae, Herba Ecliptae, Fructus Corni, Folium Eriobotryae, Caulis Polygoni Multiflori, Radix Scrophulariae, Flos Lonicerae, Radix Scutellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Radix Panacis Quinquefolii, Herba Cyperi Iriae, Radix Talini Paniculati, the Rhizoma Pinelliae, Chimonanthus Nitens and Herba Asplenii Sarelii.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 20 weight portion ~ 30 weight portion, Radix Asparagi 30 weight portion ~ 40 weight portion, the Radix Paeoniae Alba 25 weight portion ~ 35 weight portion, Radix Platycodonis 15 weight portion ~ 25 weight portion, Cordyceps 30 weight portion ~ 40 weight portion, Bulbus Fritillariae Cirrhosae 20 weight portion ~ 30 weight portion, Herba Sarcandrae 15 weight portion ~ 25 weight portion, Herba Ecliptae 20 weight portion ~ 30 weight portion, Fructus Corni 30 weight portion ~ 40 weight portion, Folium Eriobotryae 15 weight portion ~ 25 weight portion, Caulis Polygoni Multiflori 25 weight portion ~ 35 weight portion, Radix Scrophulariae 20 weight portion ~ 30 weight portion, Flos Lonicerae 30 weight portion ~ 40 weight portion, Radix Scutellariae 25 weight portion ~ 35 weight portion, Radix Glycyrrhizae 15 weight portion ~ 25 weight portion, Rhizoma Polygonati 30 weight portion ~ 40 weight portion, Radix Panacis Quinquefolii 40 weight portion ~ 50 weight portion, Herba Cyperi Iriae 20 weight portion ~ 30 weight portion, Radix Talini Paniculati 25 weight portion ~ 35 weight portion, the Rhizoma Pinelliae 20 weight portion ~ 30 weight portion, Chimonanthus Nitens 10 weight portion ~ 20 weight portion and Herba Asplenii Sarelii 10 weight portion ~ 20 weight portion.
3. the Chinese medicine composition as described in claim 1 to 2, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 23 weight portion ~ 27 weight portion, Radix Asparagi 33 weight portion ~ 37 weight portion, the Radix Paeoniae Alba 28 weight portion ~ 32 weight portion, Radix Platycodonis 18 weight portion ~ 22 weight portion, Cordyceps 33 weight portion ~ 37 weight portion, Bulbus Fritillariae Cirrhosae 23 weight portion ~ 27 weight portion, Herba Sarcandrae 18 weight portion ~ 22 weight portion, Herba Ecliptae 23 weight portion ~ 27 weight portion, Fructus Corni 33 weight portion ~ 37 weight portion, Folium Eriobotryae 18 weight portion ~ 22 weight portion, Caulis Polygoni Multiflori 28 weight portion ~ 32 weight portion, Radix Scrophulariae 23 weight portion ~ 27 weight portion, Flos Lonicerae 33 weight portion ~ 37 weight portion, Radix Scutellariae 28 weight portion ~ 32 weight portion, Radix Glycyrrhizae 18 weight portion ~ 22 weight portion, Rhizoma Polygonati 33 weight portion ~ 37 weight portion, Radix Panacis Quinquefolii 43 weight portion ~ 47 weight portion, Herba Cyperi Iriae 23 weight portion ~ 27 weight portion, Radix Talini Paniculati 28 weight portion ~ 32 weight portion, the Rhizoma Pinelliae 23 weight portion ~ 27 weight portion, Chimonanthus Nitens 13 weight portion ~ 17 weight portion and Herba Asplenii Sarelii 13 weight portion ~ 17 weight portion.
4. the Chinese medicine composition as described in claims 1 to 3, it is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Rehmanniae Preparata 25 weight portion, Radix Asparagi 35 weight portion, the Radix Paeoniae Alba 30 weight portion, Radix Platycodonis 20 weight portion, Cordyceps 35 weight portion, Bulbus Fritillariae Cirrhosae 25 weight portion, Herba Sarcandrae 20 weight portion, Herba Ecliptae 25 weight portion, Fructus Corni 35 weight portion, Folium Eriobotryae 20 weight portion, Caulis Polygoni Multiflori 30 weight portion, Radix Scrophulariae 25 weight portion, Flos Lonicerae 35 weight portion, Radix Scutellariae 30 weight portion, Radix Glycyrrhizae 20 weight portion, Rhizoma Polygonati 35 weight portion, Radix Panacis Quinquefolii 45 weight portion, Herba Cyperi Iriae 25 weight portion, Radix Talini Paniculati 30 weight portion, the Rhizoma Pinelliae 25 weight portion, Chimonanthus Nitens 15 weight portion and Herba Asplenii Sarelii 15 weight portion.
CN201510854995.2A 2015-11-28 2015-11-28 Medicine for treating lung cancer radiotherapy complication Pending CN105343523A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510854995.2A CN105343523A (en) 2015-11-28 2015-11-28 Medicine for treating lung cancer radiotherapy complication

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510854995.2A CN105343523A (en) 2015-11-28 2015-11-28 Medicine for treating lung cancer radiotherapy complication

Publications (1)

Publication Number Publication Date
CN105343523A true CN105343523A (en) 2016-02-24

Family

ID=55319681

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510854995.2A Pending CN105343523A (en) 2015-11-28 2015-11-28 Medicine for treating lung cancer radiotherapy complication

Country Status (1)

Country Link
CN (1) CN105343523A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108836985A (en) * 2018-07-31 2018-11-20 合肥迈可罗生物工程有限公司 Application of the Cordyceps fermented product in preparation prevention and treatment tumor cachexia and antitumor drug or food

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108836985A (en) * 2018-07-31 2018-11-20 合肥迈可罗生物工程有限公司 Application of the Cordyceps fermented product in preparation prevention and treatment tumor cachexia and antitumor drug or food
CN108836985B (en) * 2018-07-31 2021-05-07 合肥迈可罗生物工程有限公司 Application of cordyceps sinensis fermentation product in preparation of medicines or foods for preventing and treating tumor cachexia and resisting tumors

Similar Documents

Publication Publication Date Title
CN103550517B (en) A kind of medicine of Hepatoma therapy
CN101829217B (en) Traditional Chinese medicine for treating chronic colitis
CN102512616B (en) Chinese medicinal anti-acne composition
CN103638361B (en) Medicine for treating cough and preparation method of medicine
CN104922639A (en) Traditional Chinese medicine stomach-nourishing pill and preparation method thereof
CN103638399A (en) Medicine for treating infantile mumps and preparation method of medicine
CN105031138A (en) Medicine for treating lumbar disc herniation and preparation method thereof
CN105343523A (en) Medicine for treating lung cancer radiotherapy complication
CN103705733B (en) One treats ARR Chinese medicinal capsule and preparation method thereof
CN106310047A (en) Traditional Chinese medicine compound for treating skin diseases caused by damp, hot and dry blood and unsmooth vein
CN103610877A (en) Traditional Chinese medicine composition for restoring and recuperating postoperative breast cancer
CN104740499A (en) Traditional Chinese medicine oral decoction for treating lung cancer
CN103316202A (en) Oral-dissolving sustained-release traditional Chinese medicine used for treating nasopharyngitis, and preparation method thereof
CN101940761A (en) Chinese herbal medicine for treating chronic gastritis
CN106177404A (en) A kind of Chinese medicine composition treating the hepatic and renal YIN deficiency and preparation method thereof
CN105963586A (en) Medicine for treating lung abscess and preparation method thereof
CN105853918A (en) Anti-cancer pharmaceutical composition
CN105434874A (en) Medicine for treating epifolliculitis and preparation method of medicine
CN103721047B (en) The medicine for the treatment of radiation pneumonia
CN105395812A (en) Traditional Chinese medicine granule for treatment of sudden deafness in emergency room and preparation method thereof
CN105688069A (en) Traditional Chinese medicinal composition for treating myocardial ischemia and preparation method of traditional Chinese medicinal composition
CN105125860A (en) Preparation for effectively treating osteoporosis
CN105147998A (en) Traditional Chinese medicine used for treating sphagitis
CN104435651A (en) Traditional Chinese medicine for protecting eyes and relieving visual fatigue
CN105012789A (en) Composition for treating cervical cancer and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160224