CN105943588A - Ointment for treating infant eczema siccum - Google Patents
Ointment for treating infant eczema siccum Download PDFInfo
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- CN105943588A CN105943588A CN201610513031.6A CN201610513031A CN105943588A CN 105943588 A CN105943588 A CN 105943588A CN 201610513031 A CN201610513031 A CN 201610513031A CN 105943588 A CN105943588 A CN 105943588A
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- ointment
- vaseline
- eczema
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses ointment for treating infant eczema siccum. The ointment is prepared from the following ingredients in parts by weight: 1 part of herba portulacae, 5 to 10 parts of honeysuckle flower, 6 to 12 parts of dandelion, 20 to 30 parts of simethicone and 50 to 60 parts of vaseline. The limitation on the clinical treatment of the eczema siccum is overcome; the eczema siccum is fundamentally treated, i.e., the moisture preserving is firstly ensured. The ointment has the advantages that the vaseline is used as a substrate; the simethicone with excellent moisture preserving performance is added; Chinese herbal medicine such as the herba portulacae, the honeysuckle flower and the dandelion with the heat clearing function is combined, so that the eczema can be effectively treated, and recurrence is prevented.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation, be specifically related to a kind of ointment for treating infant dry eczema.Belong to doctor
Medicine technical field.
Background technology
Infant eczema also known as " infantile eczema ", is common a kind of dermatosis in infant period, is found in 2~3 months the earliest
Baby, the probability occurred after 2 years old can reduce.Infant eczema betides buccal, forehead, glabella and head mostly, seriously
Time trunk extremity also there will be.
The cause of disease of infant eczema is more complicated, and its morbidity is relevant with multiple internal and external factor, is sometimes difficult to the most concrete cause of disease.
Infant often by sensitizing agents such as digestive tract dietary intake allergen such as fish, shrimp, beef and mutton, eggs, makes internal generation I
Allergic reaction type.The height sickness rate of infant eczema is thin mainly due to infant keratodermatitis, and capillary network enriches,
And endothelium is aqueous and chloride is more, thus it is susceptible to allergy.Additionally, mechanical friction such as saliva and excessive milk warp
Often stimulate, be also the inducement of primary disease.Nurse improper alkaline soap as stronger in excessive use, too high nutrition, and enteral is different
Often fermentations etc. also can cause primary disease.Some baby, especially at non-neonate, owing to parent estrogen passes to tire by Placenta Hominis
Youngster, so that neonate sebum increases, easily causes seborrheic eczema.Some baby has genetic anaphylactic predisposition (atopy quality),
Family also has the medical histories such as atoipc dermatitis, ichthyosis, asthma or allergic rhinitis, infant to food anaphylaxis, IgE in blood
Numerical value increases, and acidophil increases.With age, (fossa cubitalis, nest) at side is bent in extremity by skin lesion gradually limit office,
The most acutely scratch, do not heal, until childhood period be even extended to adult age.Some extrinsic factor such as daylight, ultraviolet,
The physical factor such as cold, damp and hot, contact silk or staple fibre, external used medicine and bacterial skin infections etc., all can draw
Play eczema or increase the weight of its state of an illness.
Dry eczema occupies significant proportion in infant eczema, and the cardinal symptom of dry eczema is pruritus, causes to infant
The biggest misery.The infant eczema ointment major part used clinically at present contains hormone, can control eczema symptom in a short time,
But relapse rate is high, and hormone preparation also results in drug dependence dermatitis, and side effect is the most.Also one is had on market
A little Chinese herbal medicine ointments, but onset is slow, it is impossible to alleviate the pruritis of infant in time.Being badly in need of one at present can be relatively
Fast relief of symptoms, can be prevented effectively from again the dry eczema external medicine preparation of recurrence simultaneously.
Summary of the invention
It is an object of the invention to as overcoming above-mentioned the deficiencies in the prior art, it is provided that a kind of for treating the soft of infant dry eczema
Unguentum.
For achieving the above object, the present invention uses following technical proposals:
A kind of ointment for treating infant eczema, is made up of the component of following weight portion: Herba Portulacae 1 part, gold
Flos Lonicerae 5~10 parts, Herba Taraxaci 6~12 parts, dimethicone 20~30 parts, vaseline 50~60 parts.
Preferably, it is made up of the component of following weight portion: Herba Portulacae 1 part, Flos Lonicerae 6~8 parts, Herba Taraxaci 7~10
Part, dimethicone 24~26 parts, vaseline 52~55 parts.
It is further preferred that be made up of the component of following weight portion: Herba Portulacae 1 part, Flos Lonicerae 7 parts, Herba Taraxaci 8
Part, dimethicone 25 parts, 53 parts of vaseline.
The preparation method of above-mentioned ointment, including step:
(1) weigh the Herba Portulacae of recipe ratio, Flos Lonicerae and Herba Taraxaci respectively, after mixing, add the water extraction 3 of 10 times of weight
Secondary, each 1 hour, extracting solution merged filtration, and being concentrated into relative density is 1.05~1.10, obtains clear paste, standby;
(2) weighing the vaseline of recipe ratio, heating is allowed to melt, and is added in vaseline by the clear paste of step (1) immediately;
(3) add dimethicone while stirring, until condensation, obtain ointment.
Beneficial effects of the present invention:
Instant invention overcomes the limitation of clinical treatment dry eczema, at all treating from dry eczema, i.e. first have to
Ensure moisturizing.The ointment of the present invention, with vaseline as substrate, with the addition of the dimethicone with superior performance of keeping humidity, and
In conjunction with the Chinese herbal medicine of heat clearing away, Herba Portulacae, Flos Lonicerae and Herba Taraxaci, it is possible to effectively treat eczema, prevent recurrence.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further elaborated, it should explanation, and the description below is merely to explain
The present invention, is not defined its content.
Embodiment 1:
A kind of ointment for treating infant eczema of the present invention, is made up of following components: Herba Portulacae 1kg, gold silver
Flower 5kg, Herba Taraxaci 6kg, dimethicone 20kg, vaseline 50kg.Its preparation method, including step:
(1) weigh the Herba Portulacae of recipe ratio, Flos Lonicerae and Herba Taraxaci respectively, after mixing, add the water extraction 3 of 10 times of weight
Secondary, each 1 hour, extracting solution merged filtration, and being concentrated into relative density is 1.05, obtains clear paste, standby;
(2) weighing the vaseline of recipe ratio, heating is allowed to melt, and is added in vaseline by the clear paste of step (1) immediately;
(3) add dimethicone while stirring, until condensation, obtain ointment.
Embodiment 2:
A kind of ointment for treating infant eczema of the present invention, is made up of following components: Herba Portulacae 1kg, gold silver
Flower 10kg, Herba Taraxaci 12kg, dimethicone 30kg, vaseline 60kg.Its preparation method, including step:
(1) weigh the Herba Portulacae of recipe ratio, Flos Lonicerae and Herba Taraxaci respectively, after mixing, add the water extraction 3 of 10 times of weight
Secondary, each 1 hour, extracting solution merged filtration, and being concentrated into relative density is 1.10, obtains clear paste, standby;
(2) weighing the vaseline of recipe ratio, heating is allowed to melt, and is added in vaseline by the clear paste of step (1) immediately;
(3) add dimethicone while stirring, until condensation, obtain ointment.
Embodiment 3:
A kind of ointment for treating infant eczema of the present invention, is made up of following components: Herba Portulacae 1kg, gold silver
Flower 6kg, Herba Taraxaci 7kg, dimethicone 24kg, vaseline 52kg.Its preparation method, including step:
(1) weigh the Herba Portulacae of recipe ratio, Flos Lonicerae and Herba Taraxaci respectively, after mixing, add the water extraction 3 of 10 times of weight
Secondary, each 1 hour, extracting solution merged filtration, and being concentrated into relative density is 1.05, obtains clear paste, standby;
(2) weighing the vaseline of recipe ratio, heating is allowed to melt, and is added in vaseline by the clear paste of step (1) immediately;
(3) add dimethicone while stirring, until condensation, obtain ointment.
Embodiment 4:
A kind of ointment for treating infant eczema of the present invention, is made up of following components: Herba Portulacae 1kg, gold silver
Flower 8kg, Herba Taraxaci 10kg, dimethicone 26kg, vaseline 55kg.Its preparation method, including step:
(1) weigh the Herba Portulacae of recipe ratio, Flos Lonicerae and Herba Taraxaci respectively, after mixing, add the water extraction 3 of 10 times of weight
Secondary, each 1 hour, extracting solution merged filtration, and being concentrated into relative density is 1.10, obtains clear paste, standby;
(2) weighing the vaseline of recipe ratio, heating is allowed to melt, and is added in vaseline by the clear paste of step (1) immediately;
(3) add dimethicone while stirring, until condensation, obtain ointment.
Embodiment 5:
A kind of ointment for treating infant eczema of the present invention, is made up of following components: Herba Portulacae 1kg, gold silver
Flower 7kg, Herba Taraxaci 8kg, dimethicone 25kg, vaseline 53kg.Its preparation method, including step:
(1) weigh the Herba Portulacae of recipe ratio, Flos Lonicerae and Herba Taraxaci respectively, after mixing, add the water extraction 3 of 10 times of weight
Secondary, each 1 hour, extracting solution merged filtration, and being concentrated into relative density is 1.10, obtains clear paste, standby;
(2) weighing the vaseline of recipe ratio, heating is allowed to melt, and is added in vaseline by the clear paste of step (1) immediately;
(3) add dimethicone while stirring, until condensation, obtain ointment.
Test example
Choose 100 example infant dry eczema patients, 3 months ages~18 months, the course of disease 7 days~1 year, Major Clinical
Performance: rubescent, is dried, and has squama, pruritus impact sleep.It is randomly divided into 5 groups, often organizes 20 examples, smear embodiment respectively
1~5 ointments prepared, smearing method is as follows: cleaned in affected part with warm water, dips ointment with clean cotton swab and is uniformly coated with
Being put on affected part, applying amount is advisable with very thin one layer of affected part uniform fold, within first day, smears once every 5 hours, the most often
It was respectively smeared once respectively at point in morning 6,2 pm and at 10 in evening, continued one week.
Criterion of therapeutical effect:
Cure: rubescent, be dried, have the symptoms such as squama all to disappear, illing skin and the visual indistinction of surrounding skin, pruritus
Disappearance infant patient sleeps and substantially improves;
Effective: rubescent, it is dried, has the symptoms such as squama to alleviate, take a turn for the better, pruritus alleviates infant patient's sleep quality and takes a turn for the better;
Invalid: symptom nothing compared with before treatment is improved.
Concrete therapeutic outcome is shown in Table 1.
Table 1. therapeutic outcome
1st day end | 2nd day end | 3rd day end | 7th day end | |
Embodiment 1 | Effective 20 examples | Effective 2 examples cure 18 examples | Cure 20 examples | Cure 20 examples |
Embodiment 2 | Effective 20 examples | Effective 2 examples cure 18 examples | Cure 20 examples | Cure 20 examples |
Embodiment 3 | Effective 20 examples | Effective 1 example cures 19 examples | Cure 20 examples | Cure 20 examples |
Embodiment 4 | Effective 20 examples | Effective 1 example cures 19 examples | Cure 20 examples | Cure 20 examples |
Embodiment 5 | Effective 20 examples | Cure 20 examples | Cure 20 examples | Cure 20 examples |
From table 1 it follows that the ointment onset of the present invention is very fast, can all cure after smearing 3 days, smear the same day
I.e. effective, it is possible to the most effectively to alleviate the pruritis etc. of infant.
Above-mentioned infant patient's one week treatment is the most persistently followed the tracks of 1 year, except 1 example patient after one month because excess is edible
Penaeus seu panulirus causes facial anaphylaxis to play erythema, and other patients have no any skin abnormality, have no adverse reaction, and dry eczema does not recurs.
Although the above-mentioned detailed description of the invention to the present invention is described, but not limiting the scope of the invention,
On the basis of technical scheme, those skilled in the art need not pay the various amendments that creative work can be made
Or deformation is still within protection scope of the present invention.
Claims (4)
1. the ointment being used for treating infant eczema, it is characterised in that be made up of the component of following weight portion:
Herba Portulacae 1 part, Flos Lonicerae 5~10 parts, Herba Taraxaci 6~12 parts, dimethicone 20~30 parts, vaseline 50~60
Part.
Ointment the most according to claim 1, it is characterised in that be made up of the component of following weight portion: Dens Equi
Herba Amaranthi tricoloris 1 part, Flos Lonicerae 6~8 parts, Herba Taraxaci 7~10 parts, dimethicone 24~26 parts, vaseline 52~55 parts.
Ointment the most according to claim 1, it is characterised in that be made up of the component of following weight portion: Dens Equi
Herba Amaranthi tricoloris 1 part, Flos Lonicerae 7 parts, Herba Taraxaci 8 parts, dimethicone 25 parts, 53 parts of vaseline.
4. the preparation method of ointment according to any one of claims 1 to 3, it is characterised in that include step:
(1) weigh the Herba Portulacae of recipe ratio, Flos Lonicerae and Herba Taraxaci respectively, after mixing, add the water extraction 3 of 10 times of weight
Secondary, each 1 hour, extracting solution merged filtration, and being concentrated into relative density is 1.05~1.10, obtains clear paste, standby;
(2) weighing the vaseline of recipe ratio, heating is allowed to melt, and is added in vaseline by the clear paste of step (1) immediately;
(3) add dimethicone while stirring, until condensation, obtain ointment.
Priority Applications (1)
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CN201610513031.6A CN105943588A (en) | 2016-06-27 | 2016-06-27 | Ointment for treating infant eczema siccum |
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CN201610513031.6A CN105943588A (en) | 2016-06-27 | 2016-06-27 | Ointment for treating infant eczema siccum |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107510708A (en) * | 2017-08-29 | 2017-12-26 | 宁波保税区攀峒信息科技有限公司 | A kind of purslane dandelion Eradicates rash cream and usage food ointment chemical product physiotherapy cream |
CN107582597A (en) * | 2017-08-29 | 2018-01-16 | 宁波保税区攀峒信息科技有限公司 | A kind of purslane dandelion Eradicates rash juice and usage food concoction chemical product physiotherapy juice |
CN107595918A (en) * | 2017-08-29 | 2018-01-19 | 宁波保税区攀峒信息科技有限公司 | A kind of purslane dandelion Eradicates rash liquid and usage food decoction chemical product treatment solution |
CN110051725A (en) * | 2019-04-22 | 2019-07-26 | 青岛市妇女儿童医院(青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心) | The externally-applied medicinal composition, preparation method and application method for treating newborn skin disease |
CN110279777A (en) * | 2019-06-27 | 2019-09-27 | 贵州苗艾科技发展有限公司 | A kind of Chinese medicine is bathed liquid and preparation method thereof |
CN110403978A (en) * | 2019-08-20 | 2019-11-05 | 南阳理工学院 | Containing the infant's repellent antipruritic composition for touching fragrant extract |
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CN103330749A (en) * | 2013-06-14 | 2013-10-02 | 沈阳创达技术交易市场有限公司 | Ointment for treating eczema |
CN105106488A (en) * | 2015-10-15 | 2015-12-02 | 青岛云天生物技术有限公司 | Traditional Chinese medicine composition for treating infantile eczema |
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CN103330749A (en) * | 2013-06-14 | 2013-10-02 | 沈阳创达技术交易市场有限公司 | Ointment for treating eczema |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107510708A (en) * | 2017-08-29 | 2017-12-26 | 宁波保税区攀峒信息科技有限公司 | A kind of purslane dandelion Eradicates rash cream and usage food ointment chemical product physiotherapy cream |
CN107582597A (en) * | 2017-08-29 | 2018-01-16 | 宁波保税区攀峒信息科技有限公司 | A kind of purslane dandelion Eradicates rash juice and usage food concoction chemical product physiotherapy juice |
CN107595918A (en) * | 2017-08-29 | 2018-01-19 | 宁波保税区攀峒信息科技有限公司 | A kind of purslane dandelion Eradicates rash liquid and usage food decoction chemical product treatment solution |
CN110051725A (en) * | 2019-04-22 | 2019-07-26 | 青岛市妇女儿童医院(青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心) | The externally-applied medicinal composition, preparation method and application method for treating newborn skin disease |
CN110279777A (en) * | 2019-06-27 | 2019-09-27 | 贵州苗艾科技发展有限公司 | A kind of Chinese medicine is bathed liquid and preparation method thereof |
CN110403978A (en) * | 2019-08-20 | 2019-11-05 | 南阳理工学院 | Containing the infant's repellent antipruritic composition for touching fragrant extract |
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Application publication date: 20160921 |