CN106902273A - Prevent and treat pharmaceutical composition, eczema ointment of infant eczema and preparation method thereof - Google Patents
Prevent and treat pharmaceutical composition, eczema ointment of infant eczema and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a kind of pharmaceutical composition, eczema ointment for preventing and treating infant eczema and preparation method thereof.The active component of the pharmaceutical composition of the preventing and treating infant eczema is prepared from by the component of following mass parts：1 10 parts of Honegsukle flower P.E, 0.5 5 parts of oat alkaloid, 0.5 5 parts of chlorhexidine gluconate.The pharmaceutical composition of preventing and treating infant eczema of the invention has clearing heat and detoxicating, scattered carbuncle detumescence, the effect of bacterio static itching-relieving, infant eczema, diaper rash Niao Xian, milk Zhen Nai Xian, bite by mosquitos, dermatorrhea eczema, allergic, itch, dermatitis, damp and hot prickly heat etc. can effectively be prevented and treated, and it is notable to the prevention effect of infant eczema, and without antibiotic, hormone, have no toxic side effect, it is gently non-stimulated to skin, and drug dependence will not be produced, will not be recurred after recovery from illness.
Description
Technical field
The present invention relates to medicine or skin care field, more particularly to a kind of pharmaceutical composition for preventing and treating infant eczema,
Infant eczema cream and preparation method thereof.
Background technology
Infant eczema, is commonly called as infantile eczema, is a kind of allergic skin inflammation that is common, being caused by internal and external factor.Its disease
It is relevant with various internal and external factors because more complicated, it is sometimes difficult to the clearly specific cause of disease.Alimentary canal dietary intake allergen, such as
The sensitizing agents such as fish, shrimp, beef and mutton, egg, can make I allergic reaction types in vivo.Additionally, mechanical friction, such as saliva and
The breast that overflows often stimulates, and is also this sick inducement.Nursing is improper, such as the stronger alkaline soap of excessive use, crosses high nutrition, Yi Jichang
Interior abnormal digestion etc. can also cause this disease.Some external factors, such as sunlight, ultraviolet, cold, damp and hot physical factor, contact
Silk goods or staple fibre, external used medicine, and bacterial skin infections etc. can cause eczema or aggravate its state of an illness.Infant is wet
The Clinical symptoms of rash has juice etc. with local erythema, papule, blister, and with violent itch, heat, meet it is wet can all make it is wet
Rash performance is notable.This sick itch difficulty is delayed, touching refractory, and easily recurrent exerbation, is made infant mood uneasy and is influenceed sleep and diet,
And secondary bacterial infection, hinder normal growth development and health.
It is general to the treatment of this disease at present using it is for oral administration apply outward prevent and treat method treatment, and clinically often contain in externally applied drug
Glucocorticoids medicine or histamine class antiallergic, side effect are more, are easily caused whole body or local adverse reaction, and treatment number of days
Can not be long.Infant skin immunity is poor, and hormone medicine side effect is more, and is easily recurred after drug withdrawal.Such as part hydrocortisone
Class medicine can cause thinning of skin, produce the side effects such as dry skin, atrophy, telangiectasis, pigmentation, even more serious
Or there is growth inhibition phenomena there may be the suppression of HPAA in person, unsuitable heavy dose of, the big face of infant
Product long-term use.Therefore it is badly in need of exploitation good effect, medicine or skin care item without hormone, the treatment infant eczema having no toxic side effect.
The content of the invention
Based on this, the invention provides a kind of pharmaceutical composition for preventing and treating infant eczema.
Concrete technical scheme is as follows：
A kind of pharmaceutical composition for preventing and treating infant eczema, its active component is prepared from by the component of following weight portion：
Honegsukle flower P.E 1-10 parts
0.5-5 parts of oat alkaloid
Chlorhexidine gluconate 0.5-5 parts.
Preferably, it is described preventing and treating infant eczema pharmaceutical composition, its active component by following weight portion component system
It is standby to form：
Honegsukle flower P.E 3-7 parts
1-3 parts of oat alkaloid
Chlorhexidine gluconate 1-3 parts.
Preferably, it is described preventing and treating infant eczema pharmaceutical composition, its active component by following weight portion component system
It is standby to form：
Honegsukle flower P.E 4.5-5.5 parts
1.5-2.5 parts of oat alkaloid
Chlorhexidine gluconate 1.5-2.5 parts.
Present invention also offers the application of aforementioned pharmaceutical compositions.
Concrete technical scheme is as follows：
Application of the above-mentioned pharmaceutical composition in the medicine or skin care item for preparing preventing and treating infant eczema.
Present invention also offers a kind of infant eczema cream.
Concrete technical scheme is as follows：
A kind of infant eczema cream, is prepared by acceptable auxiliary material in above-mentioned pharmaceutical composition and medicine or skin care item
Form.
Preferably, percentage by weight of the described pharmaceutical composition in infant eczema cream is 2-20%.
Preferably, percentage by weight of the described pharmaceutical composition in infant eczema cream is 8-10%.
Preferably, the infant eczema cream is prepared from by the raw material of following percentage by weight：Aforementioned pharmaceutical compositions
8-10%, PEG400 2.5-3.5%, octadecyl alcolol 2.5-3.5%, vaseline 3.5-4.5%, aliphatic alcohol polyethenoxy
(25) ether 0.5-1.5%, silicone oil 1.5-2.5%, isopropyl myristate 3.5-4.5%, benzoic acid 0.05-0.15, emulsification increases
Thick dose of 305 1.5-2.5%, propane diols 3.5-4.5%, menthol 0.15-0.25%, butanediol 3.5-4.5%, vitamin E
0.45-0.55%, vitamin B1 0.45-0.55%, essence 0.15-0.25%, water surplus.
Present invention also offers the preparation method of above-mentioned infant eczema cream.
Concrete technical scheme is as follows：
A kind of preparation method of above-mentioned infant eczema cream, comprises the following steps：
Water, PEG400, propane diols, butanediol and aliphatic alcohol polyethenoxy (25) ether are added in kettle, is heated molten
Solution, obtains aqueous mixture；
Octadecyl alcolol, vaseline, silicone oil, isopropyl myristate, benzoic acid, the and of emulsifing thickener 305 are added in oil cauldron
Menthol, heating for dissolving obtains oil mixture；
Aqueous mixture and oil mixture are pumped into vacuum emulsifying machine, homogeneous stirs, dimension life is added after cooling
Pharmaceutical composition described in plain E, vitamin B1, essence and claim any one of 1-3, homogeneous stirs, cooling, and discharging is
.
Preferably, the temperature of the heating for dissolving is 70-80 DEG C, and the cooling is to be cooled to 35-45 DEG C.
Pharmaceutical composition, infant eczema cream of preventing and treating infant eczema of the invention and preparation method thereof have following excellent
Point and beneficial effect：
The present inventor by long-term experience accumulation and it is substantial amounts of experimental studies have found that：By Honegsukle flower P.E,
Oat alkaloid and chlorhexidine gluconate pharmaceutical composition resulting after being coordinated with special ratios have significant preventing and treating baby
The effect of infantile eczema.The pharmaceutical composition of preventing and treating infant eczema of the invention is mutually tied with plant extracts, Chinese medicine with Western medicine
Close, with clearing heat and detoxicating, scattered carbuncle detumescence, the effect of bacterio static itching-relieving, can effectively prevent and treat infant eczema, diaper rash Niao Xian, milk rash
Nai Xian, bite by mosquitos, dermatorrhea eczema, allergic, itch, dermatitis, damp and hot prickly heat etc., and to the prevention effect of infant eczema
Significantly.
The pharmaceutical composition of preventing and treating infant eczema of the invention, without antibiotic, hormone, has no toxic side effect, to skin
It is gentle non-stimulated, and drug dependence will not be produced, will not be recurred after recovery from illness.
The baby children being prepared from acceptable specific auxiliary material in pharmaceutical composition of the invention cooperation skin care item or medicine
Youngster's eczema ointment has the curative effect of significant preventing and treating infant eczema, and gently non-stimulated to skin, has no toxic side effect.
Specific embodiment
Below by way of specific embodiment to the pharmaceutical composition of infant eczema of the invention, infant eczema cream and its system
Preparation Method is described in detail.
Honegsukle flower P.E：Chlorogenic acid content more than 80%, purchased from Xi'an Yuan Sen bio tech ltd.
Other raw materials are commercially available mill run.
The complete entitled polyacrylamide of the chemistry of emulsifing thickener 305 (and) C13-14 isoparaffins (and) C9-11 alkanols
Polyethers -6.
Embodiment 1
The present embodiment provides a kind of infant eczema cream, is prepared from the following materials：
| Material name | Mass percent |
| Honegsukle flower P.E | 5% |
| Oat alkaloid | 2% |
| Gluconic acid chlorhexidine | 2% |
| PEG400 | 3 |
| Octadecyl alcolol | 3 |
| Vaseline | 4 |
| Aliphatic alcohol polyethenoxy (25) ether | 1 |
| Silicone oil | 2 |
| Isopropyl myristate | 4 |
| Benzoic acid | 0.1 |
| Emulsifing thickener 305 | 2 |
| Propane diols | 4 |
| Menthol | 0.2 |
| Butanediol | 4 |
| Vitamin E | 0.5 |
| Vitamin B1 | 0.5 |
| Essence | 0.2 |
| Water | Surplus |
The preparation method of the infant eczema cream of the present embodiment is as follows：
Water, PEG400, propane diols, butanediol and aliphatic alcohol polyethenoxy (25) ether are added in kettle, is heated to
75 DEG C of dissolvings, obtain aqueous mixture；
Octadecyl alcolol, vaseline, silicone oil, isopropyl myristate, benzoic acid, the and of emulsifing thickener 305 are added in oil cauldron
Menthol, is heated to 75 DEG C of dissolvings, obtains oil mixture；
Aqueous mixture and oil mixture are pumped into vacuum emulsifying machine, homogeneous stirs, added after being cooled to 40 DEG C
Enter vitamin E, vitamin B1, essence, Honegsukle flower P.E, oat alkaloid and gluconic acid chlorhexidine, homogeneous stirs,
38 DEG C are cooled to, discharging, quality inspection, packing is filling, packaging is obtained final product.
Embodiment 2
The present embodiment provides a kind of infant eczema cream, is prepared from the following materials：
| Material name | Mass percent |
| Honegsukle flower P.E | 3% |
| Oat alkaloid | 3% |
| Gluconic acid chlorhexidine | 1% |
| PEG400 | 3 |
| Octadecyl alcolol | 3 |
| Vaseline | 4 |
| Aliphatic alcohol polyethenoxy (25) ether | 1 |
| Silicone oil | 2 |
| Isopropyl myristate | 4 |
| Benzoic acid | 0.1 |
| Emulsifing thickener 305 | 2 |
| Propane diols | 4 |
| Menthol | 0.2 |
| Butanediol | 4 |
| Vitamin E | 0.5 |
| Vitamin B1 | 0.5 |
| Essence | 0.2 |
| Water | Surplus |
The preparation method of the infant eczema cream of the present embodiment is with embodiment 1.
Embodiment 3
The present embodiment provides a kind of infant eczema cream, is prepared from the following materials：
The preparation method of the infant eczema cream of the present embodiment is with embodiment 1.
Comparative example 1
This comparative example provides a kind of infant eczema cream, is prepared from the following materials：
The preparation method of the infant eczema cream of this comparative example is with embodiment 1.
Comparative example 2
This comparative example provides a kind of infant eczema cream, is prepared from the following materials：
| Material name | Mass percent |
| Oat alkaloid | 2% |
| Gluconic acid chlorhexidine | 2% |
| PEG400 | 3 |
| Octadecyl alcolol | 3 |
| Vaseline | 4 |
| Aliphatic alcohol polyethenoxy (25) ether | 1 |
| Silicone oil | 2 |
| Isopropyl myristate | 4 |
| Benzoic acid | 0.1 |
| Emulsifing thickener 305 | 2 |
| Propane diols | 4 |
| Menthol | 0.2 |
| Butanediol | 4 |
| Vitamin E | 0.5 |
| Vitamin B1 | 0.5 |
| Essence | 0.2 |
| Water | Surplus |
The preparation method of the infant eczema cream of this comparative example is with embodiment 1.
Comparative example 3
This comparative example provides a kind of infant eczema cream, is prepared from the following materials：
The preparation method of the infant eczema cream of this comparative example is with embodiment 1.
Comparative example 4
This comparative example provides a kind of infant eczema cream, is prepared from the following materials：
The preparation method of the infant eczema cream of this comparative example is with embodiment 1.
Embodiment 4
Infant eczema cream to embodiment 1-3 and comparative example 1-4 carries out clinical effect trial.
First, subject
Choose 240 eczema infant patients, be equally divided into 8 groups, every group of men and women half and half, each group age, surname not, the course of disease
Etc. aspect there are no significant difference.
2nd, given the test agent, application method
The infant eczema cream that given the test agent is prepared for the infant eczema cream and comparative example 1-4 of embodiment 1-3；Using
999 baby Asian puccoon eczema ointments (three nine-day periods after the winter solstice medicine company) are as a control group.
Application method：Applied with eczema ointment and put affected part on the skin, 3 times a day, be within one week a course for the treatment of, continuously two courses for the treatment of of treatment, control
Other drugs are disabled during treatment.Paid a return visit after using 3 months and 6 months respectively.
3rd, evaluation of clinical curative effect standard
1st, cure：Fash, red pimple, erythema, small water scar, the yellow scales of skin that peel off and silly skin, ooze out, the clinical symptoms whole such as erosion
Disappear, physical rehabilitation；
2nd, effectively：Clinical symptom relief, improvement；
3rd, it is invalid：Symptom is compared with pre-treatment without improvement.
4th, result on trial analysis
Result is as shown in table 1.During the infant eczema cream of subject's embodiment on probation and comparative example, do not go out
There is slight adverse reaction in existing adverse reaction, 999 baby Asian puccoon eczema ointments of control group.Infant eczema cream of the invention by
There is preferable synergistic function in the pharmaceutical composition of its active component, cure rate is high, the baby children far above comparative example 1-4
Youngster's eczema ointment.Wherein preferably, after trying out 2 courses for the treatment of, total effective rate reaches 100% to the effect of embodiment 1.To embodiment 1-3's
Recovery from illness patient is paid a return visit respectively behind 3 months and 6 months, and no case was recurrence.
The infant eczema cream clinical effect trial result of table 1
| Packet | Recovery from illness/example | Effectively/example | Invalid/example | Adverse reaction/example |
| Embodiment 1 | 25 | 5 | 0 | 0 |
| Embodiment 2 | 20 | 8 | 2 | 0 |
| Embodiment 3 | 21 | 7 | 2 | 0 |
| Comparative example 1 | 3 | 16 | 11 | 0 |
| Comparative example 2 | 3 | 18 | 9 | 0 |
| Comparative example 3 | 5 | 17 | 8 | 0 |
| Comparative example 4 | 0 | 7 | 23 | 0 |
| Control group | 14 | 10 | 6 | 5 |
It is below the specific case in part：
Case 1：Baby, man, 5 months.Described according to baby mother：There is erythema in 2 months or so face trunks after her son's life,
Papule, blister is rotten to the corn, and the skin damaged such as incrustation occurs repeatedly, and companion cry and screamed more than January.Through multi-treatment DeGrain.Finally select
Affected part is put in infant eczema cream prepared by the embodiment of the present invention 1, three paintings in the day on the skin, after 3 days, left and right face, head it is red
Spot is decorporated, and the white scales of skin that peel off comes off, and is cured completely after 4 days.
Case 2：Child, female, 1 years old.Described according to baby mother：Probably there is erythema, mound when 8 months big in her daughter
The eczema symptom such as rash, blister, erosion, often cries and screams more than.Through multi-treatment DeGrain.Finally select the embodiment of the present invention 1
The infant eczema cream of preparation, 3 times a day, and affected part is put in painting on the skin, is taken effect after 2 days, and baby's erythema, papule decorporate, start incrustation, white
The color scales of skin that peel off comes off, and after 3 days, fresh skin occurs in the incrustation eczema part that comes off, uses to the 5th day baby's eczema and cures completely.
Embodiment described above only expresses several embodiments of the invention, and its description is more specific and detailed, but simultaneously
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. it is a kind of prevent and treat infant eczema pharmaceutical composition, it is characterised in that its active component by following weight portion component
It is prepared from：
Honegsukle flower P.E 1-10 parts
0.5-5 parts of oat alkaloid
Chlorhexidine gluconate 0.5-5 parts.
2. it is according to claim 1 preventing and treating infant eczema pharmaceutical composition, it is characterised in that its active component by with
The component of lower weight portion is prepared from：
Honegsukle flower P.E 3-7 parts
1-3 parts of oat alkaloid
Chlorhexidine gluconate 1-3 parts.
3. it is according to claim 2 preventing and treating infant eczema pharmaceutical composition, it is characterised in that its active component by with
The component of lower weight portion is prepared from：
Honegsukle flower P.E 4.5-5.5 parts
1.5-2.5 parts of oat alkaloid
Chlorhexidine gluconate 1.5-2.5 parts.
4. the pharmaceutical composition described in any one of claim 1-3 is in the medicine or skin care item for preparing preventing and treating infant eczema
Using.
5. a kind of infant eczema cream, it is characterised in that pharmaceutical composition and medicine as described in claim any one of 1-3
Or acceptable auxiliary material is prepared from skin care item.
6. infant eczema cream according to claim 5, it is characterised in that described pharmaceutical composition is in infant eczema cream
In percentage by weight be 2-20%.
7. infant eczema cream according to claim 6, it is characterised in that described pharmaceutical composition is in infant eczema cream
In percentage by weight be 8-10%.
8. infant eczema cream according to claim 7, it is characterised in that prepared by the raw material of following percentage by weight and
Into：Pharmaceutical composition 8-10%, PEG400 2.5-3.5% described in claim any one of 1-3, octadecyl alcolol 2.5-
3.5%th, vaseline 3.5-4.5%, aliphatic alcohol polyethenoxy (25) ether 0.5-1.5%, silicone oil 1.5-2.5%, myristic acid are different
Propyl ester 3.5-4.5%, benzoic acid 0.05-0.15, the 1.5-2.5% of emulsifing thickener 305, propane diols 3.5-4.5%, menthol
0.15-0.25%, butanediol 3.5-4.5%, vitamin E 0.45-0.55%, vitamin B1 0.45-0.55%, essence
0.15-0.25%, water surplus.
9. the preparation method of the infant eczema cream described in a kind of claim 8, it is characterised in that comprise the following steps：
Addition water, PEG400, propane diols, butanediol and aliphatic alcohol polyethenoxy (25) ether in kettle, heating for dissolving,
Obtain aqueous mixture；
Octadecyl alcolol, vaseline, silicone oil, isopropyl myristate, benzoic acid, emulsifing thickener 305 and peppermint are added in oil cauldron
Brain, heating for dissolving obtains oil mixture；
Aqueous mixture and oil mixture are pumped into vacuum emulsifying machine, homogeneous stirs, added after cooling vitamin E,
Pharmaceutical composition described in vitamin B1, essence and claim any one of 1-3, homogeneous is stirred, and cooling, discharging is obtained final product.
10. the preparation method of infant eczema cream according to claim 9, it is characterised in that the temperature of the heating for dissolving
It is 70-80 DEG C to spend, and the cooling is to be cooled to 35-45 DEG C.
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| CN201710117602.9A CN106902273A (en) | 2017-03-01 | 2017-03-01 | Prevent and treat pharmaceutical composition, eczema ointment of infant eczema and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019033585A1 (en) * | 2017-08-15 | 2019-02-21 | 广州无添加主义化妆品有限公司 | Method for extracting oat alkaloid, and spray and preparation method therefor |
| CN115282168A (en) * | 2022-08-30 | 2022-11-04 | 马应龙大健康有限公司 | Soothing moisturizer for relieving infantile eczema symptom and preparation method and application thereof |
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| US20160228477A1 (en) * | 2015-02-09 | 2016-08-11 | Amorepacific Corporation | Method for improving skin condition or anti-microorganisms or anti-oxidation using lactobacillus sakei md honeysuckle |
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