CN109432155A - A kind of infant eczema composition and preparation method thereof - Google Patents
A kind of infant eczema composition and preparation method thereof Download PDFInfo
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- CN109432155A CN109432155A CN201811493443.3A CN201811493443A CN109432155A CN 109432155 A CN109432155 A CN 109432155A CN 201811493443 A CN201811493443 A CN 201811493443A CN 109432155 A CN109432155 A CN 109432155A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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Abstract
The present invention provides a kind of infant eczema composition, each component including following mass percent: pot marigold tincture 3-10%, glycerol 10-20%, stearic acid 5-10%, 30% sodium hydroxide solution 5-10%, saualane 5-10%, pure water 40-70%.The infant eczema composition, main component are pot marigold tincture, are the main component of calendula extract, and be aided with glycerol, and stearic acid sodium and saualane are not stimulated mildly, had no toxic side effect, and treatment infant eczema is quick, good effect.
Description
Technical field
The present invention relates to eczema treatment technical fields, and in particular, to a kind of infant eczema composition and its preparation side
Method.
Background technique
Infant eczema is commonly called as infantile eczema, is a kind of common, allergic skin inflammation as caused by internal and external factor.Symptom
Mostly based on chronic repeatability itch, influence to sleep.It is often spy with the chronic recurrent dermatitis of the sides in the wrong such as fossa cubitalis, popliteal nest
Sign, to occur intensive grain grain size papule, papulo-vesicle or blister on the basis of erythema, blister forms rotten to the corn face after breaking for initial damage,
There is serosity exudation, forms a scab.Acute eczema is dealt with improperly, and subacute or chronic eczema can be switched to, and such as appropriate treatment in time can be by
It gradually improves, but easy to recur.Large stretch of erythema can occur for severe one, be thereon papule in groups, papulo-vesicle, blister, erosive exudating, surface has
Thick scab can also extend to entire Head And Face or incidence.There is erythematous papules, papulo-vesicle, blister, conscious itch in perilesional.It wipes
It is broken that rotten to the corn, incrustation can occur, there is fester exudation under scab, there are pimple, regional glandular enlargement, tenderness in edge.Nearby or it is far apart
Position can also have parallel line shaped erythema, papule and blister caused by scratching.Infant eczema hinders normal growth and development and health.
The treatment of this disease is generally treated using the prevention and treatment method for oral administration applied outside at present, and is clinically often contained in externally applied drug
Glucocorticoids medicine or group amine antiallergic, side effect is more, easily leads to whole body or local adverse reaction, and treat number of days
It cannot be too long.Infant skin immunity is poor, and hormone medicine side effect is more, and easy to recur after drug withdrawal.Such as part hydrocortisone
Class drug will lead to thinning of skin, generate the side effects such as dry skin, atrophy, telangiectasis, pigmentation, even more serious
There may be the inhibition of hypothalamus-pituitary-adrenal axis by person, or growth inhibition phenomena, the unsuitable large dosage of infant, big face occur
Product is used for a long time.Therefore it is badly in need of development efficacy drug or skin care item good, without hormone, the treatment infant eczema having no toxic side effect.
Summary of the invention
For overcome the deficiencies in the prior art, the present invention provides a kind of infant eczema composition, main component is
Pot marigold tincture, is the main component of calendula extract, and is aided with glycerol, and stearic acid sodium and saualane do not stimulate mildly, nontoxic
Side effect, treatment infant eczema is quick, good effect.
Technical scheme is as follows: a kind of infant eczema composition, each component including following mass percent:
Pot marigold tincture 3-10%, glycerol 10-20%, stearic acid 5-10%, 30% sodium hydroxide solution 5-10%, saualane 5-10%,
Pure water 40-70%.
Preferably, the infant eczema composition, each component including following mass percent: pot marigold tincture 3-8%,
Glycerol 12-17%, stearic acid 6-8%, 30% sodium hydroxide solution 6-9%, saualane 5-8%, pure water 50-68%.
Preferably, the infant eczema composition, each component including following mass percent: pot marigold tincture 4.4%,
Glycerol 15%, stearic acid 8%, 30% sodium hydroxide solution 6%, saualane 7%, pure water 59.6%.
The preparation method of the infant eczema composition, includes the following steps:
(5) it is weighed by formula each component；
(6) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(7) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(8) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
The pot marigold tincture oil contains " carotenoid " race substance --- and lutein also contains luteole, mineral phosphor
With vitamin C etc., there is real antioxidation, linoleic acid and carrotene abundant can improve sensitive skin, have
Releive, reduce swelling, antibacterial, anti-inflammatory and other effects, improve wrinkle, black eye, sunburn, frostbite, bruise, diaper rash, whelk and mark,
The skin of microfilament exposed vessel.To skin have well moisten and Regeneration and Repair effect, can delaying skin aging, pre- anti-melanin
It is calm.It also have the function of it is preferable it is anti-inflammatory, promote wound healing and maintenance mark, therefore be often used in wound care or
Handle the skin problems such as sunburn, frostbite, whelk wound, eczema, mark.Pot marigold tincture has anti-corrosion, and anti-inflammatory effect is suitble to
Incised wound, burn, the symptoms such as ulcer.
The glycerol has the function of moisturizing.
The stearic acid can prevent from aoxidizing, so that eczema composition generates pearly gloss
30% sodium hydroxide solution has disinfection water suction, the effect of moisturizing.In the application, 30% sodium hydroxide solution
It is reacted with stearic acid, neutralizes eczema composition pH, stimulate product mildly not.
The saualane is the squalene extracting haveing excellent performance.Scientific research discovery, saualane is rare chemical stability
Height, the splendid animal fat of use feeling have preferable compatibility to skin, will not cause allergy and stimulation, and can accelerate formula
Middle other active components are permeated into skin；With lower polarity and medium spreadability, and pure, colourless, free from extraneous odour；Also
It can inhibit the growth of mould.
The pure water is the solvent of other each components, is played the role of with moisturizing.In order to make the infant eczema
Composition becomes combination agent, contains vaseline, rubber, rosin, zinc oxide etc..
The invention has the benefit that experiment shows infant eczema composition of the present invention for treating baby children
1-5 days or so visible good efficacies of youngster's eczema, do not stimulate mildly, have no toxic side effect, be worthy of popularization.
Specific embodiment
In order to make goal of the invention of the invention, technical solution and technical effect are more clearly understood, below with reference to specific reality
Applying mode, the present invention is described further.It should be understood that specific embodiment described herein, for explaining only the invention,
It is not intended to limit the present invention.
Embodiment 1, a kind of infant eczema composition, each component including following mass percent: pot marigold tincture 3%,
Glycerol 5%, stearic acid 5%, 30% sodium hydroxide solution 8%, saualane 9%, pure water 70%.
The preparation method of the infant eczema composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
Embodiment 2, a kind of infant eczema composition, each component including following mass percent: pot marigold tincture 5%,
Glycerol 18%, stearic acid 5%, 30% sodium hydroxide solution 5%, saualane 5%, pure water 62%.
The preparation method of the infant eczema composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
Embodiment 3, a kind of infant eczema composition, each component including following mass percent: pot marigold tincture 10%,
Glycerol 20%, stearic acid 10%, 30% sodium hydroxide solution 10%, saualane 10%, pure water 40%.
The preparation method of the infant eczema composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
A kind of infant eczema composition of embodiment 4, each component including following mass percent: pot marigold tincture 3%, it is sweet
Oil 12%, stearic acid 6%, 30% sodium hydroxide solution 6%, saualane 5%, pure water 68%.
The preparation method of the infant eczema composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
A kind of infant eczema composition of embodiment 5, each component including following mass percent: pot marigold tincture 8%, it is sweet
Oil 17%, stearic acid 8%, 30% sodium hydroxide solution 9%, saualane 8%, pure water 50%.
The preparation method of the infant eczema composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
A kind of infant eczema composition of embodiment 6, each component including following mass percent: pot marigold tincture 5%, it is sweet
Oil 15%, stearic acid 7%, 30% sodium hydroxide solution 7%, saualane 6%, pure water 58%.
The preparation method of the infant eczema composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
A kind of infant eczema composition of embodiment 7, each component including following mass percent: pot marigold tincture 4.4%,
Glycerol 15%, stearic acid 8%, 30% sodium hydroxide solution 6%, saualane 7%, pure water 59.6%.
The preparation method of the infant eczema composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
Clinical trial
Clinical effect trial is carried out to the infant eczema composition of embodiment 1-7.
One, subject
Choose 240 eczema infant patients, be equally divided into 8 groups, every group of men and women is fifty-fifty, each group the age, surname not, the course of disease
Etc. there are no significant difference.
Two, given the test agent, application method
Given the test agent is the infant eczema composition of embodiment 1-7, and uses 999 baby's Asian puccoon eczema compositions (three
Nine medicine companies) as a control group.
Application method: affected part is put on the skin with the painting of eczema composition, 3 times a day, 7 days as a course for the treatment of, deactivates other during treatment
Drug.It is paid a return visit after using 1 month and 3 months respectively.
Three, evaluation of clinical curative effect standard
1, cure: the clinical symptoms such as fash, red pimple, erythema, small water scar, the yellow scales of skin that peel off and silly skin, exudation, erosion are whole
It disappears, physical rehabilitation；
2, effectively: clinical symptom relief, improvement；
3, invalid: symptom is compared with pre-treatment without improvement.
Four, result on trial is analyzed
The results are shown in Table 1.Subject tries out infant eczema composition and the infant eczema combination of embodiment 1-7
During object, do not occur adverse reaction, slight adverse reaction occur in 999 baby's Asian puccoon eczema compositions of control group.
Infant eczema composition of the invention is cured since the pharmaceutical composition of its active constituent has preferable synergistic function
Rate is high, is much higher than control group.Wherein the effect of embodiment 7 is best, and after trying out 1 course for the treatment of, total effective rate reaches 100%.To reality
The recovery from illness patient for applying a 1-7 pays a return visit respectively behind 1 month and 3 months, and no case was recurrence.
1 infant eczema composition clinical effect trial result of table
| Grouping | Recovery from illness/example | Effectively/example | In vain/example | Adverse reaction/example |
| Embodiment 1 | 20 | 8 | 2 | 0 |
| Embodiment 2 | 19 | 7 | 3 | 0 |
| Embodiment 3 | 21 | 5 | 4 | 0 |
| Embodiment 4 | 21 | 8 | 1 | 0 |
| Embodiment 5 | 23 | 7 | 0 | 0 |
| Embodiment 6 | 25 | 5 | 0 | 0 |
| Embodiment 7 | 29 | 1 | 0 | 0 |
| Control group | 10 | 8 | 10 | 2 |
The following are the specific cases in part:
Case 1: baby, female, 6 months.Describe according to baby mother: there is erythema, mound in 2 months or so face trunks after baby is raw
Rash, blister, the skin lesions such as erosion occur repeatedly, and companion cry and screamed more than January.It is unobvious through multi-treatment effect.Finally select the present invention real
The infant eczema composition of the preparation of example 7 is applied, applies three times within the day and puts affected part on the skin, after 2 days, left and right face, the erythema on head are equal
It decorporates, white scales fall off, and cure completely after 3 days.
Case 2: child, female, 1.5 years old.Describe according to baby mother: probably there is erythema when 8 months are big in her daughter,
Papule, blister, the eczemas symptom such as erosion are often cry and screamed more than.It is unobvious through multi-treatment effect.Finally select the embodiment of the present invention
The infant eczema composition of 7 preparations, 3 times a day, affected part is put in painting on the skin, is taken effect after 1 day, baby's erythema, papule decorporate, start to tie
Scab, white scales fall off, and after 2 days, fresh skin occurs in the incrustation eczema part that falls off, control completely using to the 3rd day baby's eczema
More.
Case 3: child, male, 8 months.Describe according to baby mother: probably there is milk rash when 6 months big in baby, often
It cries and screams more than.There is intensive grain grain size papule, papulo-vesicle or blister, erythema in forehead, on the face, the positions such as fossa cubitalis, popliteal nest.Through more
Square therapeutic effect is unobvious.The infant eczema composition for finally embodiment of the present invention 7 being selected to prepare, 3 times a day, painting put trouble on the skin
Place takes effect after 2 days, and baby's erythema, papule decorporate, start incrustation, white scales fall off, after 3 days, the eczema part that falls off of forming a scab
There is fresh skin, uses to the 4th day baby's eczema and cure completely.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, architectural form cans be flexible and changeable, can be with derivative series product.It only makes several
Simple deduction or replace all shall be regarded as belonging to present invention scope of patent protection determined by the appended claims.
Claims (4)
1. a kind of infant eczema composition, which is characterized in that each component including following mass percent: pot marigold tincture 3-
10%, glycerol 10-20%, stearic acid 5-10%, 30% sodium hydroxide solution 5-10%, saualane 5-10%, pure water 40-
70%.
2. infant eczema composition as described in claim 1, which is characterized in that each group including following mass percent
Point: pot marigold tincture 3-8%, glycerol 12-17%, stearic acid 6-8%, 30% sodium hydroxide solution 6-9%, saualane 5-8% are pure
Water purification 50-68%.
3. infant eczema composition as claimed in claim 2, which is characterized in that each group including following mass percent
Point: pot marigold tincture 4.4%, glycerol 15%, stearic acid 8%, 30% sodium hydroxide solution 6%, saualane 7%, pure water
59.6%.
4. the preparation method of infant eczema composition as described in any one of claims 1-3, which is characterized in that including such as
Lower step:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, the infant eczema composition is made.
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| CN201811493443.3A CN109432155A (en) | 2018-12-07 | 2018-12-07 | A kind of infant eczema composition and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811493443.3A CN109432155A (en) | 2018-12-07 | 2018-12-07 | A kind of infant eczema composition and preparation method thereof |
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Cited By (1)
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| CN109394815A (en) * | 2018-12-28 | 2019-03-01 | 肖文秀 | A kind of infant's skin tonic composition and preparation method thereof |
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| DE20320103U1 (en) * | 2003-12-23 | 2004-07-15 | Weber & Weber Gmbh & Co. Kg | Composition for topical treatment of skin, useful for treating e.g. eczema and pruritus, comprises a fatty alcohol and three specific plant extracts |
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Application publication date: 20190308 |