CN106581663A - Composition for treating hormone-dependent dermatitis - Google Patents
Composition for treating hormone-dependent dermatitis Download PDFInfo
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- CN106581663A CN106581663A CN201611262087.5A CN201611262087A CN106581663A CN 106581663 A CN106581663 A CN 106581663A CN 201611262087 A CN201611262087 A CN 201611262087A CN 106581663 A CN106581663 A CN 106581663A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
Abstract
The invention relates to a composition for treating hormone-dependent dermatitis. The composition comprises mussel soft tissue extract, trypsin, Lithospermum erythrorhizon extract and purslane extract, and also optionally comprises other carriers. The composition has anti-inflammation, anti-allergy, restoration and flesh engendering effects, and has a good treatment effect on the hormone-dependent dermatitis through adjusting the immunity of skins and promoting metabolism of skin cells, the above formula contains no glucocorticoid substances or antibiotics and can be used for a long term without generating dependence, and the composition is also suitable for acnes, acneiform dermatitis, various eczemas, acute and chronic dermatitis, mite dermatitis, and fungus induced psoriasis, porrigo, tinea corporis and manus and tinea pedis, has no toxic or side effects, and has high safety and large cure rate when clinically used.
Description
Technical field
The present invention relates to biomedicine technical field, more particularly, to a kind of combination for treating steroid dependent dermatitis
Thing.
Background technology
Steroid dependent dermatitis is the dermatitis caused because of prolonged and repeated improperly external application hormone, shows as external application sugar cortical hormone
Primary skin damaged disappears after element, but inflammatory damage occurs again after disabling, and needs Reusability glucocorticoid to control symptom and gradually
A kind of dermatitis for increasing.
Steroid dependent dermatitis has the two big origin causes of formation：First is that chronic skin patient abuses for a long time medicine formation
Steroid dependent dermatitis, patient pursues the reasons such as drug effect is rapid when facial skin disease is treated, and causes facial sugar cortex
The generation of steroid dependent dermatitis is in rising trend, and this is that more traditional disease sends out reason；Second is Zhong Duoai in recent years
Beauty scholar has been used with cosmetics the effects such as nti-freckle, whitening, crease-resistant, tender skin, anti-acne, antiallergic, many illegal businessmans in order to
Product quick acting is pursued, glucocorticoid is added into cosmetics and aesthetic care products, particularly internet is quick
Development, to more three-without-products containing glucocorticoid huge living space is provided, and accelerates steroid dependent dermatitis
The flood tide outburst of patient populations.
Mussel (Mytilusedulis Linnaeus) is a kind of sea mollusk, belongs to bivalve shellfish, is commonly called as " blue or green
Mouthful " and " mussel ", each coastwise contries of throughout world.Mussel species are various, and only coastal area of china just has kind more than 30, and economic worth is higher
Have kind more than 10, wherein Mytilus galloprovincialis, Perna viridis and Trachyostracous mussel is main breed variety.Enriched Mussel containing protein, fat,
The nutrients such as carbohydrate, calcium, phosphorus, iron, riboflavin, niacin, and with very high medical value.
Trypsase (Trypsin, Parenzyme), EC 3.4.21.4 are the one kind extracted from the pancreas of ox, sheep, pig
Serine protein hydrolase.The precursor trypsinogen of pancreas manufacture is secreted into after small intestine, and erepsin activates it, becomes pancreas egg
White enzyme.Trypsase is endopeptidase, the carboxyl that it can optionally in the lysine and arginine residues of hydrolyzed peptide chain.
Trypsase not only plays digestive ferment, and can also limit decomposition chymotrypsinogen, procarboxypeptidase, phosphatide proenzyme etc. other
The precursor of enzyme, plays activation.
Asian puccoon (Lithospermum erythrorhizon Sieb.et Zucc) is Boraginaceae Lithospermum perennial herb
Plant, Radix Arnebiae extract is a kind of chemical substance, also known as shikonin, shikonin, d-alkanin, purple flaky crystal or crystallinity powder
End, 147～149 DEG C of fusing point ,+138 ° of optical activity (benzene) is water insoluble, is dissolved in ethanol, organic solvent and vegetable oil.It is soluble in alkali
Water, meets acid Precipitation again.Alkannin, with the effect such as anticancer, anti-inflammatory, antibacterial, is clinically used for treating acute hepatitis, chronic hepatitis, liver
Hardening (ascites)；Dept. of dermatology is used to treat flat wart, psoriasis, topical application treatment burn and promotion wound healing；Eye drops
For treating herpes simplex keratitis, there is certain curative effect to epitheliated type dendroid and shallow essential layer dendritic keratitis；Finish
For treating infant dermatitis, eczema, vaginitis, cervicitis etc.；Toothpaste containing alkannin can prevent and treat tooth dental caries and gingivitis；Also
Can be used for the colouring agent of medicine, cosmetics and food.
Purslane (Portulacaoleracea L), is portulacaceous plant, is the traditional Chinese medicine of China, with scattered blood
Detumescence, it is clearing heat and detoxicating the effect of, be one of 78 kinds of integration of drinking and medicinal herbs wild plants of the Ministry of Public Health of China regulation.The herb of purslane
Containing materials such as abundant adrenaline, flavones, cardiac glycosides, result of study shows：Contain what is enriched in seed, the leaf of purslane
Omega-fatty acid, omega-fatty acid can effectively reduce arachidonic generation, unsaturated in human body (especially skin)
Aliphatic acid is important anti-inflammatory component.Purslane extract is to extract to be had from the stem and leaf of purslane using low temperature method
There is the extract of biologically active, and be dissolved in certain density butanediol solution, with anti-drying aging, increase skin in the winter time
Skin comfort level and removing free radical, improve the combination property of skin comfort etc..
Steroid dependent dermatitis is a kind of refractory dermatoses, and current clinical treatment steroid dependent dermatitis is relied primarily on
Hormone decreasing therapy, immunosuppressant treatment method, Treatment of TCM, also need to combination antibiotic treatment when serious.Even if such as
This, nor especially desirable, treatment cycle is long, large side effects for traditional therapeutic effect, and knock-on is frequent, and overall cure rate is low,
Make troubles to patient work, life.
The content of the invention
For solve the treatment existing for existing steroid dependent dermatitis treatment product not thoroughly, easily repeatedly, side effect it is strong, easily
The defect such as the resistance to the action of a drug or DeGrain is formed, the present invention proposes a kind of composition for treating steroid dependent dermatitis, including
Mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract.
One or more embodiments of the invention, the composition can be by weight：Mussel soft tissue is carried
Take thing 0.2-20 parts, trypsase 0.2-10 parts, Radix Arnebiae extract 1-10 parts and purslane extract 5-10 parts.
One or more embodiments of the invention, based on the weight of composition, mussel soft tissue extract can be with
Such as 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part,
0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts,
5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts,
12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5
Part, 19 parts, 19.5 parts, 20 parts etc., trypsase can be such as 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45
Part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part, 1.5
Part, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts,
9.5 parts, 10 parts etc., Radix Arnebiae extract can be such as 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts,
5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts etc., purslane extract can be such as 5
Part, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, any concrete weight portion in 10 parts etc..
Further, the composition also includes by weight：Vitamin B3：10～40 parts, vitamin B2：1～10 part,
Vitamin E：10～20 parts, L- vitamin Cs：5～20 parts, green-tea extract 5-10 parts.
One or more embodiments of the invention, in the composition：Mussel soft tissue extract, tryptose
Enzyme, Radix Arnebiae extract and purslane extract can be individually insulated presence or can be mixed.Here, " isolation is present " refers to
Four kinds of compositions exist with the non-interfering independent packaging for keeping respective property." being mixed " refers to that four kinds of compositions are mixed
In a packaging, then or, the combination of two component/tri- components is present, and separates with other components and exist.
One or more embodiments of the invention, in the composition：Mussel soft tissue extract and tryptose
Enzyme, Radix Arnebiae extract and purslane extract can be dry powder.
One or more embodiments of the invention, in the composition：Mussel soft tissue extract and tryptose
Enzyme, Radix Arnebiae extract and purslane extract can be liquid.
One or more embodiments of the invention, the composition is formulated as the final ph after liquid for 2.5-
9.0, for example, it is preferable to pH value is 4.5-8.0, or, such as preferable ph is 5.5-7.0.
One or more embodiments of the invention, the mussel soft tissue extract refer to mussel except shell with
Outer component namely mussel soft tissue is raw material, is extracted and the supernatant of acquisition, wherein protein content through acidic aqueous solution
For 0.2-15mg/ml, pH value 1.0-6.0.Especially, can be with byssus as raw material.
One or more aspects of the invention, the mussel includes in Mytilus galloprovincialis, Perna viridis, Trachyostracous mussel
Kind, two or three.
One or more embodiments of the invention, the acidic aqueous solution can include：Acetic acid-acetate buffer
Liquid, acetic acid, citric acid, perchloric acid etc., but not limited to this.
One or more embodiments of the invention, the protein content of the mussel soft tissue extract can be
Such as 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml, 0.9mg/ml,
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml etc., but not limited to this.
One or more embodiments of the invention, the trypsase can be conventional purchase from the market.
Alternatively, the trypsase can be by saltouing, it is prepared by the method such as column chromatography.
One or more embodiments of the invention, the Radix Arnebiae extract can be conventional purchase from the market
's.Alternatively, the Radix Arnebiae extract can be by method systems such as direct extraction method, soxhlet extraction, ultrasonic extractions
Standby.
One or more embodiments of the invention, the purslane extract can be conventional purchase from the market
's.Alternatively, the purslane extract can be prepared by methods such as water extraction method, enzyme extraction method, ultrasonic extractions
's.
Another aspect of the present invention is related to a kind of pharmaceutical composition for treating steroid dependent dermatitis, wherein, the medicine
Composition can include mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract.
One or more embodiment of the invention, described pharmaceutical composition can also include pharmaceutically acceptable
Carrier.
One or more embodiments of the invention, described pharmaceutical composition can be foaming agent.
One or more embodiments of the invention, described pharmaceutical composition can be gel.
One or more embodiments of the invention, described pharmaceutical composition can be effervescent tablet.
One or more embodiments of the invention, described pharmaceutical composition can be emulsion.
One or more embodiments of the invention, the carrier can include any and all of solvent, salt,
Decentralized medium, coating material, surfactant, antioxidant, preservative (such as antiseptic, antifungal agent), isotonic agent, absorption
Delayed-action activator, drug stabilizing agent, adhesive, excipient, disintegrant, lubricant, sweetener, flavouring, dyestuff etc. and they in one
Kind, various or whole combinations, this is well-known to those skilled in the art (for example, see Remington's
Pharmaceutical Sciences,18th Ed.Mack Printing Company,1990,pp.1289-1329).Except
Outside the carrier incompatible with active component, it is contemplated that any conventional carrier used in treatment use or pharmaceutical composition.
One or more embodiments of the invention, to experimenter in need combination of the invention is given
Thing, the composition is made up of mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract.
One or more embodiments of the invention, the mussel soft tissue extract, trypsase, Asian puccoon are extracted
Thing and purslane extract can be mixed in composition.
One or more embodiments of the invention, the mussel soft tissue extract, trypsase, Asian puccoon are extracted
Thing and purslane extract can be individually insulated to be present in composition.Here, when by mussel soft tissue extract, tryptose
When enzyme, Radix Arnebiae extract and purslane extract combination medicine-feeding, administration can be order of administration or be administered simultaneously, preferably can be with
It is order of administration.For order of administration, can be by mussel soft tissue extract, trypsase, Radix Arnebiae extract and dent
Amaranth extract is administered in any order.For example, can first give mussel soft tissue extract and give trypsase again and give purple again
Careless extract and purslane extract, with this sequence alternate administration whole treatment is continued, or can first give trypsase again
Give mussel soft tissue extract and give Radix Arnebiae extract and purslane extract again, continue entirely to control with this sequence alternate administration
Treat, or can be in every day for the treatment of with different order administration.
The beneficial effect of the invention is：Said composition has anti-inflammatory, antiallergic, reparation, promoting muscle growth functions, by adjusting skin
Immunologic function and promotion skin cell metabolism, for treatment cosmetics contact dermatitis, steroid dependent dermatitis have
Good effect, in the formula of the present invention glucocorticoids material and antibiotic are not contained, and Long-Time Service does not have dependence, nothing
Toxic and side effect, Clinical practice is safe and cure rate ratio is big.
Specific embodiment
Following examples are illustrated by taking the composition for treating steroid dependent dermatitis as an example, but not limited to this, above-mentioned
Invention propose the various hormones comprising mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract according to
Bad property dermatitis in treatment product is applied to the present invention.
Embodiment 1：The preparation method of mussel soft tissue extract.
Take mussel to shell, collect soft tissue 300g, be divided into three parts, per part adds in the table 1 below of 100ml contents 0.3%
Acid solution, centrifugation after homogenate 10min obtains supernatant and is mussel soft tissue extract.
Protein content and pH value in supernatant is determined, protein content is determined using Coomassie Brilliant Blue.
Table 1
| Example | Acid solution | Protein content | PH value |
| 1 | Citric acid | 2.6mg/ml | 4.5 |
| 2 | Acetic acid | 3.5mg/ml | 3.2 |
| 3 | Perchloric acid | 3.0mg/ml | 1.0 |
Embodiment 2：A kind of combination of mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract
Object plane film.
Composition in the present embodiment is combined by following weight：Mussel soft tissue extract 10mg, trypsase
10mg, Radix Arnebiae extract 15mg and purslane extract 15mg, vitamin B3：5mg, vitamin B2：3mg, vitamin E：
15mg, L- vitamin C：16mg, green-tea extract 15mg, add deionized water to form facial mask liquid after fully dissolving.By face paper
Face is spread on after absorbent solution in immersion facial mask liquid, 15-20 removes facial mask after minute.
Collect 12 volunteers and participate in test, using mussel soft tissue extract, trypsase, Radix Arnebiae extract and dent
The composition facial mask of amaranth extract, applies once daily, and 10 days is a course for the treatment of, and recurrence is paid a return visit and recorded in 1 month.
Curative effect determinate standard：Parameters for observation on effect includes skin damaged (erythema, papule, acne infringement, telangiectasis)
And itch.
Standards of grading：Indices are scored by 4 grades of point systems：0 point=nothing, 1 point=slight, 2 points=moderate, 3
Point=severe.Evaluated according to therapeutic index, integrate before therapeutic index=(integrating after integrating before treatment-treating)/treatment ×
100%.
Recovery from illness：Skin damaged and symptom disappear, therapeutic index ＞ 90%；
It is effective：Skin damaged is most of to disappear, and symptom substantially mitigates, and therapeutic index is 60%～90%；
Take a turn for the better：Skin damaged and symptom mitigation, therapeutic index is 20%～59%；
It is invalid：Skin damaged and symptom are not improved, therapeutic index ＜ 20%.
Total effective rate fully recovering+it is effective in terms of.
Curative effect is shown in Table 2.
Table 2:Test curative effect
| Recovery from illness | It is effective | Take a turn for the better | It is invalid | It is total | Efficient (%) |
| 6 | 5 | 1 | 0 | 12 | 91.67 |
Embodiment 3：A kind of combination of mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract
Object plane film.
Composition in the present embodiment is combined by following weight：Mussel soft tissue extract 50mg, trypsase
30mg, Radix Arnebiae extract 25mg and purslane extract 25mg, vitamin B3：60mg, vitamin B2：15mg, vitamin E：
30mg, L- vitamin C：30mg, green-tea extract 25mg, add deionized water to form facial mask liquid after fully dissolving.By face paper
Face is spread on after absorbent solution in immersion facial mask liquid, 15-20 removes facial mask after minute.
Collect 14 volunteers and participate in test, using mussel soft tissue extract, trypsase, Radix Arnebiae extract and dent
The composition facial mask of amaranth extract, applies once daily, and 10 days is a course for the treatment of, and recurrence is paid a return visit and recorded in 1 month.
Curative effect determinate standard：Parameters for observation on effect includes skin damaged (erythema, papule, acne infringement, telangiectasis)
And itch.
Standards of grading：Indices are scored by 4 grades of point systems：0 point=nothing, 1 point=slight, 2 points=moderate, 3
Point=severe.Evaluated according to therapeutic index, integrate before therapeutic index=(integrating after integrating before treatment-treating)/treatment ×
100%.
Recovery from illness：Skin damaged and symptom disappear, therapeutic index ＞ 90%；
It is effective：Skin damaged is most of to disappear, and symptom substantially mitigates, and therapeutic index is 60%～90%；
Take a turn for the better：Skin damaged and symptom mitigation, therapeutic index is 20%～59%；
It is invalid：Skin damaged and symptom are not improved, therapeutic index ＜ 20%.
Total effective rate fully recovering+it is effective in terms of.
Curative effect is shown in Table 3.
Table 3:Test curative effect
| Recovery from illness | It is effective | Take a turn for the better | It is invalid | It is total | Efficient (%) |
| 5 | 8 | 1 | 0 | 14 | 92.85 |
Embodiment 4：A kind of combination of mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract
Object plane film.
Composition in the present embodiment is combined by following weight：Mussel soft tissue extract 18mg, trypsase
16mg, Radix Arnebiae extract 18mg and purslane extract 20mg, add deionized water to form facial mask liquid after fully dissolving.By face
Face is spread on after absorbent solution in film paper immersion facial mask liquid, 15-20 removes facial mask after minute.
Collect 18 volunteers and participate in test, using mussel soft tissue extract, trypsase, Radix Arnebiae extract and dent
The composition facial mask of amaranth extract, applies once daily, and 10 days is a course for the treatment of, and recurrence is paid a return visit and recorded in 1 month.
Curative effect determinate standard：Parameters for observation on effect includes skin damaged (erythema, papule, acne infringement, telangiectasis)
And itch.
Standards of grading：Indices are scored by 4 grades of point systems：0 point=nothing, 1 point=slight, 2 points=moderate, 3
Point=severe.Evaluated according to therapeutic index, integrate before therapeutic index=(integrating after integrating before treatment-treating)/treatment ×
100%.
Recovery from illness：Skin damaged and symptom disappear, therapeutic index ＞ 90%；
It is effective：Skin damaged is most of to disappear, and symptom substantially mitigates, and therapeutic index is 60%～90%；
Take a turn for the better：Skin damaged and symptom mitigation, therapeutic index is 20%～59%；
It is invalid：Skin damaged and symptom are not improved, therapeutic index ＜ 20%.
Total effective rate fully recovering+it is effective in terms of.
Curative effect is shown in Table 4.
Table 4:Test curative effect
| Recovery from illness | It is effective | Take a turn for the better | It is invalid | It is total | Efficient (%) |
| 6 | 10 | 2 | 0 | 18 | 88.89 |
Embodiment 5：A kind of combination of mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract
Object plane film.
Composition in the present embodiment is combined by following weight：Mussel soft tissue extract 12mg, trypsase
13mg, Radix Arnebiae extract 20mg and purslane extract 18mg, vitamin B3：25mg, vitamin B2：8mg, vitamin E：
25mg, L- vitamin C：26mg, green-tea extract 18mg, add deionized water to form facial mask liquid after fully dissolving.By face paper
Face is spread on after absorbent solution in immersion facial mask liquid, 15-20 removes facial mask after minute.
Collect 10 volunteers and participate in test, using mussel soft tissue extract, trypsase, Radix Arnebiae extract and dent
The composition facial mask of amaranth extract, applies once daily, and 10 days is a course for the treatment of, and recurrence is paid a return visit and recorded in 1 month.
Curative effect determinate standard：Parameters for observation on effect includes skin damaged (erythema, papule, acne infringement, telangiectasis)
And itch.
Standards of grading：Indices are scored by 4 grades of point systems：0 point=nothing, 1 point=slight, 2 points=moderate, 3
Point=severe.Evaluated according to therapeutic index, integrate before therapeutic index=(integrating after integrating before treatment-treating)/treatment ×
100%.
Recovery from illness：Skin damaged and symptom disappear, therapeutic index ＞ 90%；
It is effective：Skin damaged is most of to disappear, and symptom substantially mitigates, and therapeutic index is 60%～90%；
Take a turn for the better：Skin damaged and symptom mitigation, therapeutic index is 20%～59%；
It is invalid：Skin damaged and symptom are not improved, therapeutic index ＜ 20%.
Total effective rate fully recovering+it is effective in terms of.
Curative effect is shown in Table 5.
Table 5:Test curative effect
| Recovery from illness | It is effective | Take a turn for the better | It is invalid | It is total | Efficient (%) |
| 4 | 5 | 1 | 0 | 10 | 90.00 |
Embodiment 6：A kind of combination of mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract
Thing.
Composition in the present embodiment is combined by following weight：Mussel soft tissue extract 25mg, trypsase
20mg, Radix Arnebiae extract 12mg and purslane extract 10mg, vitamin B3：18mg, vitamin B2：10mg, vitamin E：
7mg, L- vitamin C：12mg, green-tea extract 18mg, add appropriate emulsifying agent and deionized water to form emulsion after fully dissolving.
Collect 18 volunteers and participate in test, using mussel soft tissue extract, trypsase, Radix Arnebiae extract and dent
The composition of amaranth extract, uses 2 times after daily face cleaning, is massaged into absorption.10 days is a course for the treatment of, pays a return visit and remembers in 1 month
Record recurrence.
Curative effect determinate standard：Parameters for observation on effect includes skin damaged (erythema, papule, acne infringement, telangiectasis)
And itch.
Standards of grading：Indices are scored by 4 grades of point systems：0 point=nothing, 1 point=slight, 2 points=moderate, 3
Point=severe.Evaluated according to therapeutic index, integrate before therapeutic index=(integrating after integrating before treatment-treating)/treatment ×
100%.
Recovery from illness：Skin damaged and symptom disappear, therapeutic index ＞ 90%；
It is effective：Skin damaged is most of to disappear, and symptom substantially mitigates, and therapeutic index is 60%～90%；
Take a turn for the better：Skin damaged and symptom mitigation, therapeutic index is 20%～59%；
It is invalid：Skin damaged and symptom are not improved, therapeutic index ＜ 20%.
Total effective rate fully recovering+it is effective in terms of.
Curative effect is shown in Table 6.
Table 6:Test curative effect
| Recovery from illness | It is effective | Take a turn for the better | It is invalid | It is total | Efficient (%) |
| 6 | 10 | 2 | 0 | 18 | 88.89 |
Certainly, the present invention can also have other various embodiments, ripe in the case of without departing substantially from spirit of the invention and its essence
Knowing those skilled in the art can make various corresponding changes and deformation, but these corresponding changes and deformation according to the present invention
The protection domain of the claims in the present invention should all be belonged to.
Claims (10)
1. a kind of composition for treating steroid dependent dermatitis, including mussel soft tissue extract, trypsase, Radix Arnebiae extract
And purslane extract.
2. it is according to claim 1 treatment steroid dependent dermatitis composition, it is characterised in that the composition is by weight
Including：Mussel soft tissue extract 0.2-20 parts, trypsase 0.2-10 parts, Radix Arnebiae extract 1-10 parts and purslane are extracted
Thing 5-10 parts, specifically, based on the weight of composition, mussel soft tissue extract is, for example, 0.2 part, 0.25 part, 0.3 part,
0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9
Part, 0.95 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5
Part, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts,
14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts, pancreas egg
White enzyme is, for example, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part,
0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5
Part, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, Radix Arnebiae extract is, for example, 1
Part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5
Part, 9 parts, 9.5 parts, 10 parts, purslane extract is, for example, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9
Part, 9.5 parts, any concrete weight portion in 10 parts.
3. according to the composition for treating steroid dependent dermatitis of claim 1 or 2, it is characterised in that the composition is also wrapped
Include：Vitamin C, vitamin B2, vitamin E, L- vitamin Cs, green-tea extract.
4. according to the composition for treating steroid dependent dermatitis of aforementioned any claim, wherein in the composition：Mussel
Soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract are individually insulated presence or are mixed；And/or its
Described in protein compositions：Mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract are dry powder
Or liquid.
5. according to the composition for treating steroid dependent dermatitis of aforementioned any claim, wherein the composition is formulated as liquid
Final ph after body is 2.5-9.0, for example, it is preferable to pH value is 4.5-8.0, for example, it is preferable to pH value is 5.5-7.0.
6. according to the composition for treating steroid dependent dermatitis of aforementioned any claim, wherein the mussel soft tissue is extracted
Thing is that, with mussel soft tissue as raw material, the supernatant for extracting through acidic aqueous solution and obtaining, wherein protein content are 0.2-
15mg/ml, pH value 1.0-6.0.
7. according to the composition for treating steroid dependent dermatitis of aforementioned any claim, wherein the mussel is made a gift of including purple
One kind in shellfish, Perna viridis, Trachyostracous mussel, two or three, and/or wherein described acidic aqueous solution includes：Acetic acid-acetic acid
Sodium buffer solution, acetic acid, citric acid, perchloric acid, or the protein content of wherein described mussel soft tissue extract is, for example,
0.2mg/ml、0.3mg/ml、0.4mg/ml、0.5mg/ml、0.6mg/ml、0.7mg/ml、0.8mg/ml、0.9mg/ml、
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml.
8. a kind of pharmaceutical composition, it is characterised in that described pharmaceutical composition is the treatment hormone according to aforementioned any claim
The composition of dependence facial dermatitis, or including the combination of the treatment steroid dependent dermatitis according to aforementioned any claim
Thing, described pharmaceutical composition includes mussel soft tissue extract, trypsase, Radix Arnebiae extract and purslane extract.
9. pharmaceutical composition according to claim 8, the composite medicine further includes pharmaceutically acceptable carrier, example
Such as solvent, salt, decentralized medium, coating material, surfactant, antioxidant, preservative, isotonic agent, absorption delaying agent, medicine
Stabilizer, adhesive, excipient, disintegrant, lubricant, sweetener, flavouring, dyestuff etc. and they in it is a kind of, various or complete
The combination in portion.
10. pharmaceutical composition according to claim 8 or claim 9, it is characterised in that described pharmaceutical composition is facial mask, emulsion, frost
Agent, paste, spray, gel or gel form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262087.5A CN106581663A (en) | 2016-12-30 | 2016-12-30 | Composition for treating hormone-dependent dermatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262087.5A CN106581663A (en) | 2016-12-30 | 2016-12-30 | Composition for treating hormone-dependent dermatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106581663A true CN106581663A (en) | 2017-04-26 |
Family
ID=58581812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611262087.5A Withdrawn CN106581663A (en) | 2016-12-30 | 2016-12-30 | Composition for treating hormone-dependent dermatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106581663A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648156A (en) * | 2017-10-26 | 2018-02-02 | 广州珈源日化用品有限公司 | A kind of essence lotion of releiving containing mussel extract |
-
2016
- 2016-12-30 CN CN201611262087.5A patent/CN106581663A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648156A (en) * | 2017-10-26 | 2018-02-02 | 广州珈源日化用品有限公司 | A kind of essence lotion of releiving containing mussel extract |
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