DE20320103U1 - Composition for topical treatment of skin, useful for treating e.g. eczema and pruritus, comprises a fatty alcohol and three specific plant extracts - Google Patents

Abstract

Composition for the topical treatment of skin diseases, especially eczema, pruritus, inflammation and/or chickenpox, comprising at least 0.5wt.% of an alcohol (I) and over 10 to 30wt.% of at least one mother tincture and/or extract (II) containing active agents from (parts of) the plants Centella asiatica, Mahonia aquifolium and/or Viola tricolor, is new. (I) is one or more of cetyl alcohol, stearyl alcohol and wool wax alcohols. ACTIVITY : Dermatological; Antipruritic; Antiinflammatory; Virucide. No biological data given. MECHANISM OF ACTION : None given.

Description

The present invention relates to a pharmaceutical preparation for the topical treatment of skin diseases, especially skin eczema, itchy skin, inflammatory skin diseases and / or chickenpox.

Skin diseases usually solve an itching sensation, which for the person concerned is uncomfortable or even unbearable and a so-called Scratch reflex triggers. The excitation of the nerve endings caused by this can happen again Trigger itching. The itching causes a new scratch reflex, which to a renewed one Itching leads. This can lead to a cycle, which sustainably damages the skin. In addition, patients with itchy skin often have dry skin.

To the common skin diseases the trigger itching or scratching, belong Neurodermatitis, allergic skin symptoms as well as skin rashes of various kinds Causes (eczema) or chickenpox. Skin eczema are reddened and flaking, sometimes also weeping Skin changes. Typical places where they appear are elbows, hollow of the knees, Neck, neck, wrists and face. They also cause eczema in most cases severe itching in these parts of the body.

Preparations for application to the Skin (dermatics) with homeopathic or herbal ingredients to treat itchy eczema or other rashes are known in the art. The manufacture and composition such preparations is, for example, in the Homeopathic Pharmacopoeia (HAB) described. For For example, ointments are specified there as water-containing wool wax alcohol ointment according to the German Pharmacopoeia (DAB) as the basis, i.e. is to be used as a carrier for active ingredients. If other foundations are used, they must be declared. The homeopathic active ingredients are incorporated into this basis.

Preparations for the treatment of itchy Eczema is known in the art. These include, for example Extracts from Centella asiatica, Mahonia aquifolium, Viola tricolor, Acidum arsenicosum, Calendula officinalis, Lytta vesicatoria and Semecarpus anacardium. Can also in these preparations Peru balsam (Balsamum peruvianum) and zinc oxide may be included. The preparations usually contain 10 wt% or less mother tincture or extract.

A disadvantage of the aforementioned preparations is that these usually show a slow onset of action. This is particularly disadvantageous when treating acute itching shall be. In addition, ointments based on wool wax alcohol ointment frequently greasy ointments for a longer one Period, for example for an hour or more remain on the skin and can form a fat film. This can cause that the active ingredients contained also not or only very slowly can penetrate the skin.

Homeopathic preparations The basis of wool wax alcohol ointment has so far only been used with a content of ≤10% by weight Extract or tincture can be made because the compositions because of the breakage of the water in oil emulsion from a weight content of> 10% by weight extract or tincture do not mix or become bulk storage during storage before bottling segregate again.

There is therefore a need for one Means that shows a faster onset of action and penetration of a higher one Active substance content allowed in the skin.

Object of the present invention is therefore to provide a pharmaceutical preparation which has at least one of the aforementioned disadvantages of the prior art technology overcomes.

The task is solved by a pharmaceutical preparation for the topical treatment of skin diseases, especially skin eczema, itchy skin, inflammatory skin diseases and / or Chickenpox, the preparation ≥0.5 % By weight, in particular ≥1 % By weight, based on the total weight of the preparation, of alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or Mixtures of these and> 10 % By weight to 30% by weight, based on the total weight of the preparation, Mother tincture (s) and / or extract (s) comprising active ingredient (s) available from Plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor.

Advantageous embodiments of the pharmaceutical according to the invention Preparation are specified in the subclaims.

A solution of the invention lying task also consists in the provision of a method for the production of a pharmaceutical preparation according to the invention.

The term "tincture" is used in the sense this invention drug extracts, the concentration prepared using ethanol appropriate are understood. In the context of the present invention, a “mother tincture” is used Mixtures of vegetable juices with alcohol / water of different concentrations and / or vegetable excerpts with solvents such as ethanol, water and / or glycerol, and / or extracts from plants or animals, their secretions and / or parts thereof. Mother tinctures are preferably made with liquid carriers such as Prepares ethanol of various concentrations, water and / or glycerol.

For the purposes of this invention, the term “extract” is used to concentrate, if appropriate to one specific active substance content, extracts from active substances of liquid, viscous or dry nature, which are obtained, for example, using ethanol.

Homeopathic are preferred Mother tinctures and dilutions, liquid alcoholic plant extracts, alcoholic and especially ethanolic Tinctures used.

surprisingly It has been found that preparations according to the invention which have a higher proportion on mother tincture (s) and / or extract (s) than usual in particular homeopathic Preparations used have an improved effect in the treatment of skin eczema, itchy skin, inflammatory Can show skin diseases and / or chickenpox. In particular, preparations according to the invention can an improved effect in the acute treatment of skin eczema, Itchy skin, inflammatory Have skin diseases and / or chickenpox.

The preparation includes mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or from parts of plants from Centella asiatica (Asian navel herb), Mahonia aquifolium (Berberis aquifolium) and / or Viola tricolor (Pansy). The preparation preferably comprises active ingredient (s) obtainable from at least one plant and / or selected from its plant parts the group comprising Centella asiatica, Mahonia aquifolium and / or Viola tricolor, preferably the preparation comprises active ingredient (s) available selected from at least two plants and / or from their plant parts the group comprising Centella asiatica, Mahonia aquifolium and / or Viola tricolor and particularly preferably the preparation comprises active ingredient (s) available selected from all plants and / or from their plant parts the group comprising Centella asiatica, Mahonia aquifolium and / or Viola tricolor. The preparation preferably comprises natural and / or synthetic active ingredient (s) available from plants and / or parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor.

Levels of mother tincture (s) and / or Extract (s) in the preparation according to the invention in the range of> 10% by weight up to 30% by weight, preferably ≥10.1 % By weight to 20% by weight, based on the total weight of the preparation, can advantageously improved treatment efficacy of an itch. In particular, these can advantageously Consider improved efficacy in the acute treatment of a Show itching.

Unless otherwise stated, are the weight contents of the respective components are chosen so that the total weight of the respective components is 100% by weight on the overall composition.

The preparation according to the invention can be preferred embodiments advantageously improved treatment efficacy of skin diseases with thickening and itching, dry skin rashes, chronic Skin disorders and rashes, especially in children's practice, for example with cradle cap, and / or show eczema. Furthermore, the preparation according to the invention advantageous for wound treatment, especially for promotion the antimicrobial and anti-inflammatory effect can be used.

Preparation according to the invention have ≥0.5% by weight, in particular ≥1 % By weight, based on the total weight of the preparation, of alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or mixtures thereof. A preparation according to the invention can advantageously with an addition of ≥0.5 % By weight, in particular ≥1 % By weight, based on the total weight of the preparation, of alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or Mixtures thereof at least partially have good stability.

Under a mixture are in mind of this invention mixtures of cetyl alcohol, stearyl alcohol and / or Wool wax alcohols in various combinations and / or proportions to understand, for example mixtures of cetyl and stearyl alcohol and / or mixtures of cetyl alcohol and wool wax alcohols. A special one preferred mixture is cetylstearyl alcohol.

Preparations according to the invention can advantageously be used even higher ones Proportions of alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or mixtures thereof. Preparations according to the invention can advantageously be used with higher Proportions of alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or mixtures thereof an increased stability exhibit.

In preferred embodiments has the pharmaceutical according to the invention Preparation at least 1% by weight, preferably at least 2% by weight, preferably at least 3% by weight, further preferably at least 4% by weight, furthermore preferably at least 5% by weight, even more preferably at least 6% by weight, more preferably at least 8% by weight, based on the Total weight of the preparation, comprising alcohols selected from the group Cetyl alcohol, stearyl alcohol, wool wax alcohols and / or mixtures thereof on. In further preferred embodiments, the preparation has Alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or mixtures thereof in the range from 1% by weight to 20% by weight, preferably in the range from 3% by weight to 10% by weight, preferably in Range from 4 wt% to 6 wt% based on the total weight the preparation, on.

Preparations according to the invention can preferably at least 1% by weight, preferably we at least 2% by weight, preferably at least 3% by weight, further preferably at least 4% by weight, further preferably at least 5% by weight, based on the total weight of the preparation, alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, Have wool wax alcohols and / or mixtures thereof. Advantageously, the stability of the preparations according to the invention can be increased at higher proportions, in particular at least 1% by weight, preferably at least 2% by weight, preferably at least 3% by weight, further preferably at least 4% by weight, further preferably at least 5% by weight. -%, based on the total weight of the preparation, of alcohols selected from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or mixtures thereof.

In particularly preferred embodiments the preparation by adding at least 1% by weight is preferred at least 2% by weight, preferably at least 3% by weight, further preferred at least 4% by weight, further preferably at least 5% by weight, still more preferably at least 6% by weight, more preferably at least 8% by weight, based on the total weight of the preparation, of alcohols selected from the group comprising cetyl alcohol, stearyl alcohol and / or mixtures stabilized against segregation. Can advantageously the stability the emulsion of the preparations according to the invention at higher Proportions of alcohols especially selected from the group comprising Cetyl alcohol, stearyl alcohol and / or mixtures thereof in preferred embodiments increase significantly. In further particularly preferred embodiments the preparation by adding alcohols is selected from the group comprising cetyl alcohol, stearyl alcohol and / or mixtures thereof in the range from 1% by weight to 20% by weight, preferably in the range from 3% by weight to 10% by weight, preferably in the range from 4% by weight to 6% by weight, based on the total weight of the preparation, against one Segregation stabilized.

The preparation according to the invention can a surprising improved stability the emulsion. The preparation according to the invention preferably has after three months, preferably six months, further preferably nine Months, more preferably 12 months, more preferably 18 months, particularly preferably 24 months and very particularly preferably 36 months Storage without cooling and / or Air conditioning, for example at temperatures in the range from 20 ° C. to 40 ° C., is preferred in the range of 21 ° C up to 30 ° C, further preferably in the range from 21 ° C. to 25 ° C., no separation of the emulsion on.

Studies of the stability of a Preparation according to the invention can by storing the preparation according to the invention in a tightly closed tube, for example in one with epoxy resin sealed aluminum tube, without cooling and / or air conditioning at 23 ° C, over a Period of several months and regular observation of the emulsion be determined. usual Preparations with a weight content of> 10% by weight extract or tincture separate while storage of the bulk goods within weeks or months. Especially preferred embodiments the preparation according to the invention for example comprising 15% by weight of mother tincture (s) and / or extract (s) and at least 1% by weight, based on the total weight of the preparation, Alcohols selected from the group comprising cetyl alcohol, stearyl alcohol and / or mixtures thereof, very particularly preferably comprising 6% by weight, based on the total weight of the preparation, cetyl alcohol, preferably have no segregation and / or crystal growth even after one year of storage and / or preferably no or negligible change on appearance, color, smell and / or pH.

The pharmaceutical preparation according to the invention can be in the form of an ointment, cream, gel or solution. To be favoured Preparation according to the invention for external Application, preferably applied to the skin. It is preferred according to the invention, that the pharmaceutical preparation as an ointment, cream and / or gel is present.

The term "ointment" is used in the sense of this Invention a single-phase, semi-solid dosage form for use the skin or mucous membranes understood, depending on their water content, hydrophobic ointments, water-absorbing ointments and hydrophilic ointments can be distinguished. Pharmaceuticals can be distinguished from creams and gels. Under the term "cream" is used in the sense of this Invention a multi-phase, semi-solid preparation from a hydrophilic and understood a lipophilic component. The term "gel" is used in the sense of this Invention a liquid gelled with the aid of swelling agents Roger that.

It is special according to the invention preferred that the pharmaceutical preparation in the form of hydrophilic Ointments, creams and / or gels are present, with hydrophilic creams and / or amphiphilic creams are preferred. There are also cooling ointments usable. Hydrophilic gel preparations as well as hydrophilic ointments and hydrophilic creams can have a cooling effect and give moisture to the skin, so that the skin dries out is avoided. The itching is also advantageously caused by the moisturizing property of the aforementioned hydrophilic Wording reduced. Creams, preferably hydrophilic creams and / or amphiphilic creams are within the scope of the present invention very particularly preferred.

Usable ointment and cream bases are described, for example, in the pharmacopoeia Deutsches Pharmacopoeia, DAB, or Homeopathic Pharmacopoeia, HAB. It is preferred according to the invention that the pharmaceutical preparation comprises DAB or DAC components (DAC: German Medicinal Codex) as ointment or cream base materials. Preferred ingredients are, for example, wool wax alcohol le, cetylstearyl alcohol, petrolatum, preferably white petroleum jelly, cetyl palmitate, waxes, artificial waxes, paraffins, vegetable oils, sobitan esters, polysorbate, glycerol, monoglycerides, glycerol monostearate 60, macrogol-1000-glycerol monostearate, macrogol-20-glyceryl alcohol alcohol monostearate Triglycerides, propylene glycol and / or cellulose derivatives. Basic materials which are particularly preferred according to the invention are glycerol monostearate 60, macrogol 1000 glycerol monostearate, macrogol 20 glycerol monostearate, cetyl alcohol, medium-chain triglycerides, white petroleum jelly and / or propylene glycol.

It is preferred that the pharmaceutical Preparation has a hydrophilic basis according to DAC, in particular hydrophilic creams based on DAC are preferred. It is special according to the invention preferred that the pharmaceutical preparation as the basis DAC base cream includes.

In particularly preferred embodiments includes the preparation, based on the total weight of the preparation:

• -> 10% by weight to 30% by weight, preferably ≥10.1 % By weight to 20% by weight, based on the total weight of the preparation, Mother tincture (s) and / or extract (s) comprising active ingredient (s) available from Plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor; and
• - 70 % By weight to <90 % By weight, preferably 80% by weight to 89.9% by weight, based on the total weight the preparation, DAC base cream,

where the weight levels of each Components selected this way are that the total weight of the components does not exceed 100% by weight.

Advantageous when using a DAC base cream is that it is pleasant to distribute on the skin is. In particular, the preparation can be based on a DAC base cream already into the skin when rubbed in. So education a fat film on the skin avoided in an advantageous manner.

Preferably, already after Applying a preparation according to the invention based on a base DAC cream in a time span in the area from 10 seconds to less than 10 minutes, preferably in the range from 30 seconds to less than two minutes after application the preparation is completely or almost residue-free on the skin to have moved in.

It was still surprising found that pharmaceutical according to the invention Preparations using a DAC base cream in particular also show a faster onset of action. These are and therefore for one Treatment of acute itching is advantageously very good suitable. A quick absorption into the skin also enables repeated application or frequent rubbing. this means a big advantage over a slower greasy ointment.

According to the invention, that mother tincture (s) and / or extract (s) in the range from> 10% by weight to 30% by weight, preferably in the range of ≥10.1 % By weight to 20% by weight, particularly preferably 15% by weight, based on the total weight of the preparation, based on a basis Ointments, creams and / or gels, preferably based on hydrophilic Ointments, creams and / or gels, water-containing hydrophilic ointments and / or amphiphilic creams are introduced. Preferred according to the invention is a salary of> 10 % By weight, particularly preferably 15% by weight of mother tincture (s), extract (s) and / or mixtures introduced into a DAC base cream.

An introduction of> 10% by weight, especially preferably 15% by weight of mother tincture (s), extract (s) and / or mixtures in an ointment-based HAB formulation is also according to the invention intended. These preparations are also characterized by an improved Effectiveness over usual Preparation with a lower content of tinctures or extracts out. It is particularly advantageous to insert them into hydrophilic gels, which improved an invention Efficacy with a skin cooling Have an effect.

The introduction of a content of> 10 wt .-%, especially preferably 15% by weight of mother tincture (s), extract (s) and / or mixtures In a DAC base cream, surprisingly, this also distinguishes itself that these preparations have increased stability. Introducing the tinctures and / or extracts into an ointment or Cream base corresponds to the formation of an emulsion, i.e. of education a disperse system of two or more together miscible substances. Such an emulsion can, in particular for longer Storage, segregate. The pharmaceutical preparation according to the invention, especially based on a DAC base cream, is more advantageous Way stable and / or has little or no degree of segregation on. In particularly preferred embodiments of the preparation according to the invention is a preparation comprising 15% by weight of mother tincture (s), extract (s) and / or Mixtures in a DAC base cream even after a longer storage period of more than three months, preferably six months, further preferably nine Months, more preferably 12 months, more preferably 18 months, particularly preferably 24 months and very particularly preferably 36 months stable and shows no segregation of the emulsion.

In a preferred embodiment includes the preparation, based on the total weight of the preparation:

• - 15 wt .-%, based on the total weight of the preparation, mother tincture (s) and / or extract (s) send active ingredient (s) available from plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor; and
• - 85 % By weight, based on the total weight of the preparation, of DAC base cream.

The preferred embodiment the preparation is quickly absorbed into the skin and preferably does not form a greasy film on the skin. Farther has the preferred embodiment no side effects of the preparation. Furthermore, the preparation stable and shows even with longer Storage no segregation. Particularly preferred embodiments the preparation according to the invention for example comprising 15% by weight of mother tincture (s) and / or extract (s) in a DAC base cream preferably show up even after a year Storage no segregation and / or no crystal growth and preferably none or negligible change on appearance, color, smell and / or pH.

In preferred embodiments the preparation has at least one, preferably at least two, preferably several mother tincture (s) and / or extract (s) of the same or different composition comprising active ingredient (s) obtainable from Plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor.

The pharmaceutical preparation can one, preferably at least two, preferably several that can be produced separately Mother tincture (s) and / or extract (s) and / or mixtures of mother tinctures comprehensive active ingredient (s) available from the plants and / or parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor include. In preferred embodiments includes the preparation of mother tinctures comprising active ingredient (s) available from the plants and / or parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor containing in each case 1% by weight to 10% by weight, preferably 3% by weight to 7% by weight, more preferably 4 wt% to 6 wt% and most preferred 5% by weight, based on the total weight of the preparation.

In a particularly preferred embodiment includes the preparation, based on the total weight of the preparation:

• - 5th % By weight, based on the total weight of the preparation, mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or from parts of plants from Centella asiatica;
• - 5th % By weight, based on the total weight of the preparation, mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or from parts of plants from Mahonia aquifolium;
• - 5th % By weight, based on the total weight of the preparation, mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or comprised of parts of plants from Viola tricolor; and
• - 85 % By weight, based on the total weight of the preparation, of DAC base cream.

The preferred embodiment the preparation has no side effects, is more beneficial Get into the skin quickly and prefer not to form a greasy film on the skin. Furthermore, the pharmaceutical preparation has a very good itch-relieving effect, is stable and shows even with longer ones Storage no segregation.

The active ingredients of the preparation according to the invention are preferably extracted from the Centella asiatica plants, Mahonia aquifolium, Viola tricolor and / or from their parts of plants and optionally from other plants described below or parts of plants or animals.

The preparation according to the invention preferably comprises Active ingredients from the Centella asiatica and Mahonia aquifolium plants and / or Viola tricolor and / or from their plant parts, for example Stem and / or root bark, selected from the group comprising essential oils, flavonol derivatives, Ursan derivatives, for example (free) asian acid and / or its trisaccharide esters, Alkaloids, preferably berberine, oxyacanthine and / or bermamine, Flavonoids, glycosides, for example violutoside (violutin) the methyl salicylate is linked to the disaccharide vicianose, Tannins, mucus and / or sugar.

The preparation according to the invention can be one or multiple mother tincture (s) and / or extract (s) comprising the above explained Active ingredients include. The preparation according to the invention preferably comprises Active ingredient (s) made from a mother tincture from the Centella plants asiatica, Mahonia aquifolium and / or Viola tricolor and / or from whose parts of the plant are obtained. The preparation according to the invention preferably comprises at least two, preferably several active ingredients selected from the group comprising active ingredient (s) obtainable from plants and / or Plant parts from Centella asiatica, Mahonia aquifolium and / or Viola tricolor.

The pharmaceutical preparation according to the invention includes mother tincture (s) and / or extract (s), the mother tincture (s) and / or extract (s) furthermore active ingredient (s) obtainable from plants and / or from parts of plants from Calendula officinalis, Semecarpus anacardium, Active ingredient (s) from Lytta vesicatoria and / or Peru balsam, Acidum arsenicosum and / or zinc oxide.

The content of the extracts and / or Tinctures of active ingredients can vary widely. Preferably can the preparation according to the invention a homeopathic Be preparation.

In further preferred embodiments, the pharmaceutical preparation further comprises natural Che and / or synthetic active ingredient (s), in particular in the form of a mother tincture, obtainable from the plants Calendula officinalis (marigold) and / or Semecarpus anacardium (ink tree) and / or from their parts of plants.

In preferred embodiments comprises the pharmaceutical preparation natural and / or synthetic Active ingredient (s), in particular in the form of a mother tincture, from the plants Calendula officinalis and / or Semecarpus anacardium and / or from their plant parts, for example the seeds, selected from of the group comprising essential oils, calendulin, Calendulosides such as saponins and / or oleanolic acid glycosides, triterpenes, ß-carotene, Lycopene, xanthophylls, flavonoids, phenolic compounds such as Cardol, tannins, resins, dye, and / or oil with anacardic acid.

Furthermore, the preparation according to the invention include as active ingredient Acidum arsenicosum (arsenic (III) oxide). Of the preparation can also be natural and / or synthetic Active ingredient (s) from Lytta vesicatoria (Spanish fly) include. Contains Lytta vesicatoria about 0.5 to 1% cantharidin, resin, fat and dye.

Preferred embodiments of the preparation according to the invention can advantageously an improved anti-inflammatory, bactericidal antimicrobial, anti-inflammatory and granulation-promoting Efficacy, especially in the treatment of inflammatory Skin diseases, poorly healing wounds and ulcers, burns, acute inflammation have blistered skin.

The pharmaceutical preparation can Peru balsam included. However, it can also be provided that embodiments of the present preparation <1 % By weight, preferably ≤0.5 % By weight, more preferably ≤0.1 % By weight and particularly preferably 50.01% by weight, based on the total weight preparation, Peru balsam. In a preferred embodiment the pharmaceutical preparation does not include Peru balsam. A pharmaceutical Preparation that comprises less than 1 wt% Peru balsam prefers to call no allergic skin reactions, especially for sensitive ones Skin.

Advantageous preparations, in particular hydrophilic gel preparations as well as hydrophilic ointments and hydrophilic creams may also contain zinc oxide. It can in other embodiments the present preparation but also be provided that the pharmaceutical preparation <5 % By weight, preferably ≤3 % By weight, more preferably ≤1 % By weight, particularly preferably 0 0.1 % By weight, based on the total weight of the preparation, and most preferably does not include zinc oxide. Preferred zinc oxide levels are also 0.5% by weight and particularly preferably 0.1% by weight, based on the total weight the preparation.

Due to a low zinc oxide content the pharmaceutical according to the invention Preparation is advantageously drying out of the skin preventable.

In particularly preferred embodiments can the pharmaceutical preparation mother tincture (s) and / or extract (s) comprehensive active ingredient (s) available from plants and / or parts of plants from Calendula officinalis, Semecarpus anacardium, active ingredient (s) from Lytta vesicatoria and / or Peru balsam, acidum arsenicosum, zinc oxide, vitamins, preferably Vitamin E, ß-carotene, Contain biotin and / or co-enzyme Q10.

Furthermore, the pharmaceutical Preparation of active ingredients, selected from the group comprising essential oils, flavonol derivatives, Ursan derivatives, berberine, oxyacanthin, bermamin, violutoside (violutin), Tannins, sugar, mucus, calendulin, calendulosides, triterpenes, ß-carotene, Lycopene, xanthophylls, anacardic acid, Arsenic (III) oxide, cantharidin, vitamins, especially vitamin E, ß-carotene, Biotin, co-enzyme Q10, zinc oxide, cinnamic acid and extractable with ether Benzoesäurebenzylestern, Resins, benzoic acid, cinnamic acid, Curcumin, curcuma rootstock extract, vanillin, nerolidol and / or Have farnisol. The pharmaceutical composition according to the invention preferably comprises Preparation of dyes. Examples of preferred dyes are Curcumin, curcuma rootstock extract, riboflavin and / or ß-carotene.

The preparation according to the invention can mother tincture (s), Extract (s) and / or mixtures in the range from> 10% by weight to 30% by weight, preferably in the Range of ≥10.1 Wt .-% to 20 wt .-%, particularly preferably 15 wt .-%, wherein the preparation contains at least one extract, mother tincture or a mixture may have, the active ingredients obtainable from one or more of the plants Centella asiatica, Mahonia aquifolium or Viola tricolor and / or has parts of their plants. The preparation according to the invention can also mother tincture (s) and / or extract (s) in the aforementioned areas have, wherein the preparation two or more extracts or Mother tinctures can have different compositions Active ingredients from one or more of the Centella asiatica plants, Mahonia aquifolium, Viola tricolor and / or their plant parts. About that can out the mother tincture (s) and / or extract (s) active ingredient (s) selected from the group comprehensively natural and / or synthetic active ingredient (s) obtainable from the plants calendula officinalis, Semecarpus anacardium and / or parts of plants thereof, natural and / or synthetic active ingredient (s) available from Lytta vesicatoria, Peru balsam, Acidum arsenicosum and / or zinc oxide include.

Furthermore, the pharmaceutical Preparation of other usual Excipients of the ointment and / or Have cream making.

It is further preferred that the preparation is ready for use. “Ready to use” in the sense of the present invention means that the pharmaceutical preparation is in the form of a ready-to-use ointment, cream or gel which is applied to the itchy or inflamed skin areas or skin eczema can be gen.

Another subject of the present Invention is a tube which is a pharmaceutical according to the invention Preparation contains.

The present invention relates to furthermore a method for producing a pharmaceutical according to the invention Preparation.

The process of making a pharmaceutical according to the invention Preparation comprises mixing extracts, preferably Mother tinctures comprising active ingredient (s) available from plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor.

In the method according to the invention for the manufacture of a pharmaceutical preparation for treatment of skin eczema, itchy skin, inflammatory skin diseases and / or Chickenpox it is preferred to be comprehensive for the mother tinctures Active ingredients available from Centella asiatica, Mahonia aquifolium and / or Viola tricolor the weight ranges mentioned above are observed.

According to the invention, that mother tincture (s) and / or extract (s) are in the range from> 10% by weight to 30% by weight, preferably> 10 % By weight to 30% by weight, preferably in the range from 10 10.1% by weight to 20% by weight, particularly preferably 15% by weight, based on the total weight of the preparation, in a base based on ointments, creams and / or gels, preferably based on hydrophilic ointments, creams and / or gels, water-based introduces hydrophilic ointments and / or amphiphilic creams. Preferred according to the invention you bring a salary of> 10 % By weight, particularly preferably 15% by weight of mother tincture (s) and / or extract (s) in a DAC base cream.

Preferably bring the mother tincture (s) and / or extract (s) in ointment or cream bases comprising DAB- or DAC ingredients, preferably DAC base cream. Preferably is a hydrophilic ointment, or a hydrophilic cream, in particular a water-based hydrophilic ointment or cream or a hydrophilic Gel can be made.

It is preferred according to the invention that the pharmaceutical preparation is made on a hydrophilic basis according to DAC, in particular there are hydrophilic creams on one DAC basis preferred for manufacturing. It is special according to the invention preferred that you base the pharmaceutical preparation a DAC base cream.

Furthermore, in the method according to the invention preferably active ingredient (s) available from the plants Calendula officinalis, Semecarpus anacardium and / or from their plant parts, active ingredient (s) obtainable from Lytta vesicatoria, Peru balsam, Acidum arsenicosum and / or zinc oxide, vitamins, preferably Vitamin E, ß-carotene, Biotin and / or co-enzyme Q10, and optionally others as above described active ingredients added.

To manufacture a pharmaceutical Preparations by the method according to the invention are more advantageous Wise stirring process usable. In particular, the pharmaceutical preparation is through simple stirring process producible, the pharmaceutical preparation is particularly preferred exclusively through simple stirring process produced. For example, the pharmaceutical preparation through simple stirring processes using rolling, shaking, or stirring mixers producible The inventive method thus simplifies the production, since complex steps such as a warming high temperatures can be dispensed with.

Another aspect of the present The invention relates to the use of a as described above pharmaceutical according to the invention Preparation including mother tincture (s) and / or extract (s) in the area from> 10% by weight to 30% by weight, based on the total weight of the preparation, for producing a Medicament for the treatment especially for the acute treatment of Eczema, itchy skin, inflammatory Skin diseases and / or chickenpox, especially for treatment of neurodermatitis.

It is particularly advantageous that the pharmaceutical according to the invention Preparation comprising mother tincture (s) and / or extract (s) Active ingredient (s) available from plants and / or parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor for the production of a Medicament for the acute treatment of skin diseases, in particular Eczema, itchy skin, inflammatory Skin diseases and / or chickenpox can be used.

Under an "acute treatment" in the sense of this Invention is the topical treatment for skin disorders Achieving a beneficial pharmaceutical effect at the time understood shortly before, during or after the appearance of the skin diseases, without this long-term administration, i.e. H. over several hours, days or Weeks is necessary. In particular, an "acute treatment" in the sense of this Invention understood the relief of acute itching.

With "acute treatment" in the sense of this Invention preferably occurs faster onset of action the relief of skin disorders, particularly an itching sensation because the preparation is based in particular on a DAC base cream can move in faster and preferably a repeatable application preparation within shorter intervals than possible when using a slower absorbing greasy ointment can.

It was also surprisingly found that a single application of the invention according preparation in particular based on a DAC base cream shows an advantageous effect in acute treatment. Acute itching in particular can be alleviated by applying the preparation according to the invention, in particular based on a DAC base cream.

It is particularly advantageous that through the avoidance of permanent administration of the aforementioned Substances and / or mixtures of substances avoided the occurrence of side effects or at least significantly reduced.

Preferred embodiments of the preparation according to the invention are also advantageous in long-term therapy of skin diseases, in particular itching and eczema.

Examples of pharmaceutical preparations which serve to illustrate the present invention given below.

Example 1: Formula for a pharmaceutical Preparation for external use with itchy eczema

The recipe includes ethanol ones Tinctures of Centella asiatica, Mahonia aquifolium and Mahonia aquifolium in an ointment base of wool wax alcohol ointment. The ointment showed a good itch-relieving effect and also with repeated application no contraindications or side effects were observed in the ointment.

Example 2: Recipe for a preparation comprehensive herbal mother tinctures for external use in itchy eczema

The recipe included ethanol Tinctures of Centella asiatica, Mahonia aquifolium and Viola tricolor in an ointment base of DAC base cream. The cream showed one good antipruritic effect and also with repeated application no contraindications or side effects were observed in the cream. The cream was already absorbed into the skin when rubbed in and left no residue Fat film on the skin. In addition, the cream was also after nine months Storage in a sealed, sealed with epoxy resin Aluminum tube at 23 ° C, stable and showed no segregation and no crystal growth.

Appearance, spreadability, Homogeneity, Color, smell of the preparation showed no change, continued to point out Preparation only minor changes of the pH value.

Claims (8)

Pharmaceutical preparation for the topical treatment of skin diseases, in particular skin eczema, itchy skin, inflammatory skin diseases and / or chickenpox, characterized in that the preparation ≥0.5% by weight, based on the total weight of the preparation, alcohols selected from the group comprising cetyl alcohol, Stearyl alcohol, wool wax alcohols and / or mixtures thereof, and> 10% by weight to 30% by weight, based on the total weight of the preparation, mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor. Pharmaceutical preparation according to claim 1, characterized in that the preparation we at least 1% by weight, preferably at least 2% by weight, preferably at least 3% by weight, further preferably at least 4% by weight, further preferably at least 5% by weight, based on the total weight of the preparation, of alcohols from the group comprising cetyl alcohol, stearyl alcohol, wool wax alcohols and / or mixtures thereof. Pharmaceutical preparation according to claim 1 or 2, characterized in that the preparation based on the Total weight of the preparation, includes:  -> 10% by weight to 30% by weight, preferably ≥10.1% by weight up to 20% by weight, based on the total weight of the preparation, mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor; and  - 70 % By weight to <90 % By weight, preferably 80% by weight to 89.9% by weight, based on the total weight the preparation, DAC base cream, the weight content of each Components selected this way are that the total weight of the components does not exceed 100% by weight. Pharmaceutical preparation according to one of the previous ones Expectations, characterized in that the preparation, based on the total weight preparation, includes:  - 15th % By weight, based on the total weight of the preparation, mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or from parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor; and  - 85 % By weight, based on the total weight of the preparation, of DAC base cream. Pharmaceutical preparation according to one of the previous ones Expectations, characterized in that the preparation at least one, preferred at least two, preferably several mother tincture (s) and / or extract (s) same or different composition comprising active ingredient (s) available from plants and / or parts of plants from Centella asiatica, Mahonia aquifolium and / or Viola tricolor. Pharmaceutical preparation according to one of the previous ones Expectations, characterized in that the preparation, based on the total weight preparation, includes:  - 5th % By weight, based on the total weight of the preparation, mother tincture (s) and / or extract (s) comprising active ingredient (s) obtainable from plants and / or from parts of plants from Centella asiatica;  - 5 wt .-%, based on the Total weight of preparation, mother tincture (s) and / or extract (s) comprehensive active ingredient (s) available from plants and / or parts of plants from Mahonia aquifolium;   - 5% by weight, based on the total weight of the preparation, mother tincture (s) and / or Extract (s) comprising active ingredient (s) obtainable from plants and / or comprised of parts of plants from Viola tricolor; and  - 85% by weight, based on the total weight of the preparation, DAC base cream. Pharmaceutical preparation according to one of the previous ones Expectations, characterized in that the mother tincture (s) and / or extract (s) Active ingredient (s) available from plants and / or parts of plants from Calendula officinalis, Semecarpus anacardium, active ingredient (s) from Lytta vesicatoria and / or Peru balsam, acidum arsenicosum, zinc oxide, vitamins, preferably Vitamin E, β-carotene, Include biotin and / or co-enzyme Q10. Pharmaceutical preparation according to one of the previous ones Expectations, characterized in that the preparation is ready for use.