DE102010019876A1 - Preparation for topical use in rheumatic diseases - Google Patents

Abstract

The invention relates to a preparation for topical use, in particular in the case of rheumatic diseases, the preparation being extracts, tinctures and / or extracts of plants and / or parts of plants from comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts of active ingredients Includes arnica (Arnica montana) and rosemary (Rosmarinus officinalis).

Description

The present invention relates to a preparation for topical use, in particular in rheumatic diseases. Further, the preparation is useful in blunt sports injuries.

Rheumatic complaints of the musculoskeletal system, which are often associated with extremely unpleasant tearing and pulling pain, are widespread. Millions of people in Germany alone suffer from rheumatic diseases, which are commonly referred to as "rheumatism". Rheumatic diseases can already occur in young adults and children; Severe rheumatic diseases can already affect infants. Due to the variety of clinical pictures, which are summarized under the term "rheumatism", the medical term for rheumatism is "diseases of the rheumatic type". Their common feature is mainly in pain, especially in joints and muscles. Typical complaints are still stiff knees, back pain, swollen and red joints.

The manifestations of rheumatic diseases vary depending on the affected organ system. For example, the epidemiologically most significant inflammatory disease of the rheumatic type, rheumatoid arthritis, leads to inflammation and deformity of the joints, especially the little finger and toe joints. However, rheumatic diseases do not only affect the joints, but also connective tissue, tendons and ligaments are affected. The causes of rheumatic diseases have not yet been conclusively clarified.

Non-steroidal anti-inflammatory drugs such as salicylic acid and glucocorticoids are mainly used for the treatment of rheumatic diseases. The most important glucocorticoids used in rheumatism include cortisone, cortisol, prednisone, prednisolone and dexamethasone. A major disadvantage of glucocorticoid therapy, especially in elderly patients, is the risk of inducing osteoporosis. In addition, the infections which frequently occur in glucocorticoid therapy represent a further significant disadvantage, in particular in long-term therapy.

Furthermore, analgesics such as paracetamol or acetylsalicylic acid are used in the treatment of rheumatic diseases, the disadvantage of which is, for example, that they show a liver-damaging effect, in particular in the case of longer-term use.

Other common complaints of the joints and the musculoskeletal system are sprains, muscle strains, dislocations, bruises, bruises and other blunt sports injuries, which are unavoidable especially with regular exercise. If sports injuries such as sprains, bruises, strains or swelling are treated quickly and correctly, pain and sequelae can be reduced.

For the treatment of sports injuries is often resorting to well-tried home remedies, such as immediate cooling and rest. Also drugs are widely used, especially pharmacy-based ointments and gels. However, many of these ointments and gels contain heparin, ibuprofen or salicylic acid, in whose particular improper use, although the pain is alleviated or swelling decrease, but many unwanted side effects occur, especially allergic reactions or hypersensitivity reactions.

In the prior art, in addition to these drug therapies also herbal medicines are known, such as ointments with arnica, which support the healing process. However, these often combine a high number of ingredients to be as widely applicable to various injuries. The disadvantage here is in particular that while active ingredients are used, which often take an unnecessary influence on the human body and further deplete the possibly weakened by inflammation processes body.

It is therefore the object of the present invention to provide a means which overcomes at least one of the aforementioned disadvantages of the prior art. In particular, it is the object of the present invention to provide a composition which is useful for the treatment of rheumatic complaints.

• a. im Bereich von ≥ 2 % bis ≤ 40%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder ≥Pflanzenteilen von Arnika (Arnika montana) oder deren Trockensubstanz;
• b. im Bereich von ≥ 1,5% bis ≤ 40%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen und/oder Extrakte von Pflanzen oder Pflanzenteilen von Beinwell (Symphytum officinale) oder deren Trockensubstanz;
• c. im Bereich von ≥ 0,5% bis ≤ 20%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis) oder deren Trockensubstanz, wobei die Gehalte der jeweiligen Komponenten so gewählt sind, dass der Gesamtgehalt der Komponenten 100% nicht übersteigt.

The object is achieved by a preparation for topical use, in particular in the case of rheumatic diseases, the preparation comprising, as active ingredients, the following extracts, tinctures, essential oils and / or extracts:

• a. in the range of ≥ 2% to ≤ 40%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or ≥plant parts of arnica (Arnica montana) or their dry matter;
• b. in the range of ≥ 1.5% to ≤ 40%, based on the total content of the preparation, extracts, tinctures and / or extracts of plants or parts of plants of comfrey (Symphytum officinale) or their dry matter;
• c. in the range of ≥ 0.5% to ≤ 20%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or plant parts of rosemary (Rosmarinus officinalis) or their dry matter, the contents of the respective components are chosen so that the total content of the components does not exceed 100%.

Advantageous embodiments of the preparation according to the invention are specified in the subclaims.

Data in percent correspond, unless otherwise indicated, to data in% by volume or% by weight, based on the total volume or total weight of the preparation. Here, the volume contents or weight contents of the respective components are chosen so that the total volume or total weight of the components does not exceed 100 vol .-% or 100 wt .-%.

The term "rheumatic diseases" for the purposes of the present invention, the various inflammatory diseases of the connective and supporting tissue, especially the musculoskeletal system, but also internal organs and the skin, which may be associated with flowing, tearing and drawing pain understood.

For the purposes of this invention, the term "dry substance" is understood to mean the dry residue of extracts, tinctures, essential oils and / or extracts, which remains after removal of the extractant. The dry substance may contain a residual proportion of extractant, for example water, which may be, for example, in the range from ≥ 1% by weight to ≦ 10% by weight, preferably in the range from ≥ 1% by weight to ≦ 5% by weight, based on the total weight of the dry substance. The dry substance can therefore also be present in viscous form. The dry substance is preferably a native dry matter of the extracts, tinctures, essential oils and / or extracts without additives. For the purposes of this invention, the term "dry extract" is understood to mean the dry residue of an extract. For the purposes of this invention, an "ethanolic dry extract" is understood to mean the dry residue of an extract after removal of the extractant ethanol.

For the purposes of this invention, the term "tincture" is understood to mean excerpted extracts and extracts from fresh plant parts or whole fresh plants, which are produced using alcohol, in particular ethanol of suitable concentration. The term "tincture" for the purposes of the present invention also includes so-called "mother tinctures" and mixtures of vegetable juices with alcohol, water and / or their mixture and / or herbal extracts. In particular, the term "tincture" drug extracts according to the Homeopathic Pharmacopoeia (HAB), German Pharmacopoeia (DAB) or European Pharmacopoeia (Ph. Eur.) And other European or American pharmacopoeia from fresh or dried plants and / or parts of plants, especially fresh plants and / or plant parts.

For the purposes of this invention, the term "extract" means concentrated extracts of plants and / or plant parts of liquid, viscous or dry nature, which are optionally adjusted to a certain active substance content, which are obtained, for example, using alcohol, in particular ethanol. For the purposes of this invention, the term "extract" also means purified extracts or extract fractions. Extracts from plants or parts of plants with essential oils can also be prepared in such a way that the essential oils are removed from the plants or plant parts prior to extraction and this is added again after extraction to the respective extract.

For the purposes of this invention, the term "essential oil" means extracts soluble in organic solvents or the organic phase of steam distillates from plants or parts of plants which usually have a characteristic odor for the original plant.

In preferred embodiments, homeopathic tinctures and extracts, especially liquid alcoholic plant extracts, or dry extracts, alcoholic and especially ethanolic extracts or essential oils are used.

Surprisingly, it has been found that a preparation according to the invention which contains as active ingredients extracts, tinctures, essential oils and / or extracts of arnica (Arnica montana) in the range of ≥ 2% to ≤ 40%, extracts, tinctures and / or extracts of comfrey (Symphytum officinale) in the range of ≥ 1.5% to ≤ 40%, and extracts, tinctures, essential oils and / or extracts of rosemary (Rosmarinus officinalis) in the range of ≥ 0.5% to ≤ 20%, based on the Total content of the preparation, or their dry matter, in particular dry extract comprises, shows an improved effect in the treatment of muscle and joint pain, rheumatic diseases, in particular the symptomatic treatment of rheumatic pain or in acute joint inflammation.

Furthermore, the preparation according to the invention also showed an improved action in the treatment of blunt trauma, for example sprains, bruises, strains, bruising, bruising and swelling.

In particular, it has surprisingly been found that the action of arnica is enhanced by use in combination with comfrey and rosemary. Without being bound to a particular theory, it is therefore assumed that the surprisingly good effect of the preparation according to the invention is produced by synergistic effects due to the extracts, tinctures, essential oils and / or extracts contained, in particular in the corresponding dosages.

The advantageous properties arise in particular by the combination of the extracts, tinctures, essential oils and / or extracts. An advantageous synergistic effect results from the selection and amount of the individual substances that have been specially selected for the treatment of muscle and joint pain, the symptomatic treatment of rheumatic pain and acute joint inflammation.

It is particularly advantageous that a good effect solely by the preparation containing extracts, tinctures and / or extracts of plants and / or plant parts of comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts of plants and / or plant parts of arnica (Arnica montana) and rosemary (Rosmarinus officinalis) can be achieved, so that can be dispensed with a variety of components. This is particularly advantageous because drugs can be associated with side effects or at least unnecessarily affect the body. In preferred embodiments, the preparation comprises only extracts, tinctures and / or extracts of plants and / or plant parts of comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts of plants and / or plant parts of arnica (Arnica montana) and Rosemary (Rosmarinus officinalis) as effective ingredients.

A significant advantage of the preparation is realized by the preparation comprising extracts, tinctures and / or extracts of plants and / or plant parts of comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts of plants and / or plant parts of Arnica (Arnica montana) and Rosemary (Rosmarinus officinalis) cause no allergic reactions or hypersensitivity reactions due to the small number of extracts, tinctures, essential oils and / or extracts of medicinal plants, as is often the case with known means. Therefore, it is particularly useful for long-term use in rheumatic diseases.

A significant advantage of the preparation is realized by the preparation comprising extracts, tinctures and / or extracts of plants and / or plant parts of comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts of plants and / or plant parts of Arnica (Arnica montana) and rosemary (Rosmarinus officinalis) as active ingredients due to the low number of extracts, tinctures, essential oils and / or extracts of effective medicinal plants preferably little or no allergies triggers. An increasing number of people suffer from allergies or hypersensitivity to ingredients of one or more plants. Hypersensitivity reactions may also occur with the use of herbal compositions. It is therefore of great advantage that the preparation according to the invention reduces the risk of such reactions due to the small number of extracts, tinctures, essential oils and / or extracts of effective medicinal plants. In particular, for persons with a tendency to allergies, this can result in advantages in use.

Of particular advantage here is that it was surprisingly found that when using the preparation according to the invention, which have a smaller number of effective medicinal plants in comparison to preparations which in addition to the medicinal plants according to the invention still other additional effective medicinal plants, nevertheless achieved a comparably good effect can be. This means that the preparation according to the invention surprisingly achieves the desired effect, for example in rheumatic diseases with a significantly lower number of medicinal plants.

It is of particular advantage that the preparation according to the invention has a lower side effect potential. In particular, the preparation may further be distinguished by the fact that it does not cause skin redness and rashes. In particularly advantageous embodiments of the preparation, this has no extracts, tinctures, essential oils and / or extracts of plants, which can cause skin redness and rashes when applied externally, such as monkshood.

In particular, the preparation according to the invention is distinguished from known plant-based agents in that the preparation contains a special dosage of extracts, tinctures, and / or extracts of comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts of arnica ( Amica montana) and rosemary (Rosmarinus officinalis) as effective ingredients.

As a lower limit for a good effectiveness, a minimum of 2%, based on the total content of the preparation, of extracts, tinctures, essential oils and / or extracts of plants or plant parts of arnica (Arnica montana) or from 2% extracts, tinctures , Essential oils and / or extracts available dry matter, especially dry extract proved to be favorable. Also, as a lower limit for a good efficacy, a minimum proportion of 0.5%, based on the total content of the preparation, of extracts, tinctures, essential oils and / or extracts of plants or plant parts of rosemary (Rosmarinus officinalis) or from 0, 5% extracts, tinctures, essential oils and / or extracts available dry matter, especially dry extract, proved to be favorable. In particular, a minimum level of 0.5%, based on the total content of the preparation, essential oil of plants or plant parts of rosemary (Rosmarinus officinalis), has proven to be favorable as a lower limit for good effectiveness. Furthermore, a minimum level of 1.5%, based on the total content of the preparation, of extracts, tinctures and / or extracts of plants or parts of plants of comfrey (Symphytum officinale) or 1.5% Extracts, tinctures and / or extracts available dry matter, especially dry extract, proved to be favorable.

Indicated percentages, unless otherwise indicated, refer to the liquid extract. If a liquid extract is concentrated, the volume or the percentage can be correspondingly lower. If a dry extract is used, this has the appropriate amount of ingredients, but advantageously a lower volume or a lower percentage than the liquid extract from which the dry extract was obtained, for example by evaporation.

• a. im Bereich von ≥ 2% bis ≤ 15%, vorzugsweise im Bereich von ≥ 5% bis ≤ 15%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Arnika (Arnica montana) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• b. im Bereich von ≥ 1,5% bis ≤ 15%, vorzugsweise im Bereich von ≥ 5% bis ≤ 15%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen und/oder Extrakte von Pflanzen oder Pflanzenteilen von Beinwell (Symphytum officinale) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• c. im Bereich von ≥ 0,5% bis ≤ 5%, vorzugsweise im Bereich von ≥ 1% bis ≤ 5% Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis) oder deren Trockensubstanz,

wobei die Gehalte der jeweiligen Komponenten so gewählt sind, dass der Gesamtgehalt der Komponenten 100% nicht übersteigt.In preferred embodiments, the preparation comprises as active ingredients the following extracts, tinctures, essential oils and / or extracts:

• a. in the range of ≥ 2% to ≤ 15%, preferably in the range of ≥ 5% to ≤ 15%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or parts of plants of arnica (Arnica montana) or their dry substance, in particular dry extract;
• b. in the range of ≥ 1.5% to ≤ 15%, preferably in the range of ≥ 5% to ≤ 15%, based on the total content of the preparation, extracts, tinctures and / or extracts of plants or plant parts of comfrey (Symphytum officinale) or their dry matter, in particular dry extract;
• c. in the range of ≥ 0.5% to ≤ 5%, preferably in the range of ≥ 1% to ≤ 5% extracts, tinctures, essential oils and / or extracts of plants or plant parts of rosemary (Rosmarinus officinalis) or their dry matter,

wherein the contents of the respective components are chosen so that the total content of the components does not exceed 100%.

• a. im Bereich von ≥ 5% bis≤ 20%, bezogen auf den Gesamtgehalt der Zubereitung, vorzugsweise 15% Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Arnika (Amica montana) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• b. im Bereich von ≥ 5% bis ≤ 20%, bezogen auf den Gesamtgehalt der Zubereitung, vorzugsweise 15% Auszüge, Tinkturen und/oder Extrakte von Pflanzen oder Pflanzenteilen von Beinwell (Symphytum officinale) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• d. im Bereich von ≥ 1% bis ≤ 10%, vorzugsweise 5% Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis) oder deren Trockensubstanz,

wobei die Gehalte der jeweiligen Komponenten so gewählt sind, dass der Gesamtgehalt der Komponenten 100% nicht übersteigt.In particularly preferred embodiments, the preparation comprises as active ingredients the following extracts, tinctures, essential oils and / or extracts:

• a. in the range of ≥ 5% to ≤ 20%, based on the total content of the preparation, preferably 15% extracts, tinctures, essential oils and / or extracts of plants or plant parts of arnica (Amica montana) or their dry matter, in particular dry extract;
• b. in the range of ≥ 5% to ≤ 20%, based on the total content of the preparation, preferably 15% extracts, tinctures and / or extracts of plants or plant parts of comfrey (Symphytum officinale) or their dry matter, in particular dry extract;
• d. in the range of ≥ 1% to ≤ 10%, preferably 5% extracts, tinctures, essential oils and / or extracts of plants or plant parts of rosemary (Rosmarinus officinalis) or their dry matter,

wherein the contents of the respective components are chosen so that the total content of the components does not exceed 100%.

An advantage is provided by the ratio of extracts, tinctures and / or extracts of comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts, specifically aimed at the treatment of muscle and joint pain, the symptomatic treatment of rheumatic pains and acute arthritis of arnica (Arnica montana) and rosemary (Rosmarinus officinalis) realized. The concerted proportions of extracts, tinctures and / or extracts of comfrey (Symphytum officinale) and extracts, tinctures, essential oils and / or extracts of arnica (Arnica montana) and rosemary rosemary (Rosmarinus officinalis) provide a balance that can show a good anti-inflammatory, antimicrobial and / or antifungal effect. This is particularly beneficial in the treatment of muscle and joint pain, the symptomatic treatment of rheumatic pain and acute joint inflammation. In addition, a circulation-enhancing effect can be provided. Of particular advantage is further that an acceleration of the cell structure and cell formation can be effected.

The preparation is also advantageously useful for use in dislocations, dull traumas, muscle and joint pain. For example, in the treatment of dislocations, dull trauma, for example sprains, bruises, strains, bruises, bruising, swelling, muscle and joint pain, it is advantageous that a decongestant and analgesic effect can be provided.

Extracts, tinctures, essential oils and extracts can be prepared from whole plants, extracts, tinctures, essential oils and extracts from whole plants or parts of plants, for example, from flowers, leaves, stems, roots or seeds of the plants are preferred. For example, extracts, tinctures, essential oils and extracts of arnica (Arnica montana) can be produced from the whole plant or the leaves, preferably from the dried flowers. Furthermore, extracts, tinctures and extracts of comfrey (Symphytum officinale) can be prepared from the herbaceous parts of plants or the leaves, preferably from the fresh or dried subterranean parts, especially the roots. Extracts, tinctures, essential oils and extracts of rosemary (Rosmarinus officinalis) from the above-ground parts, in particular flowers and / or leaves, are preferably preparable.

In preferred embodiments, the preparation comprises extracts, tinctures and / or extracts of comfrey root and / or extracts, tinctures, essential oils and / or extracts of Arnica flowers and of the aerial parts of rosemary.

In preferred embodiments, extracts of plants and / or plant parts of arnica (Arnica montana) and comfrey (Symphytum officinale) are present in the form of an aqueous-ethanolic extract. Extracts and tinctures according to pharmacopoeia are preferably preparable by means of ethanol-water mixtures. In further preferred embodiments, an arnica (Arnica montana) essential oil is also usable.

Preferably, the concentration of ethanol of the aqueous-ethanolic extract of arnica (Arnica montana) ranges from 30% to 86% (v / v), especially 70% (v / v). Preferably, the concentration of ethanol of the aqueous ethanolic extract of comfrey (Symphytum officinale) is 30% to 86% (v / v). Preferably, the weight ratio of the macerated or percolated plant parts of arnica (Arnica montana) to the extract, the so-called drug / extract ratio (DEV), in the range of 1: 1 to 1:10 (m / m), preferably 1: 10 (m / m). Preferably, the weight ratio of the macerated or percolated plant parts of comfrey (Symphytum officinale) to the extract, the so-called drug / extract ratio, in the range of 1: 1 to 1:10 (m / m).

In preferred embodiments, the preparation comprises alcoholic, aqueous, or aqueous-alcoholic extracts of plants and / or plant parts of arnica (Arnica montana) and comfrey (Symphytum officinale). In also preferred embodiments, the preparation comprises an arnica essential oil (Arnica montana). In further preferred embodiments, the preparation comprises dry extracts obtainable from alcoholic, aqueous or aqueous-alcoholic extracts of plants and / or plant parts of arnica (Arnica montana) and comfrey (Symphytum officinale). In preferred embodiments, the preparation comprises an essential oil of rosemary (Rosmarinus officinalis). Rosemary essential oil is preferably obtainable by steam distillation from the flowering aerial parts.

In particularly preferred embodiments, the preparation comprises aqueous-ethanolic extracts or dry extracts of plants and / or plant parts of arnica (Arnica montana) and comfrey (Symphytum officinale) and an essential oil of rosemary (Rosmarinus officinalis). In also preferred embodiments, the preparation comprises aqueous ethanolic extracts or dry extracts of plants and / or plant parts of comfrey (Symphytum officinale) and an essential oil of arnica (Arnica montana) and rosemary (Rosmarinus officinalis).

The preparation of the invention, the active ingredients in particular extracts, tinctures, essential oils and / or extracts in liposomal or liposomal encapsulated form, d. H. contained in liposomes. The preparation according to the invention can therefore also be present in a liposomal dosage form. An advantage of the embodiments in which the preparation comprises extracts, tinctures, essential oils and / or extracts in liposomally encapsulated form is that the active ingredients in liposomally encapsulated form can more readily overcome the barrier layer of the skin.

In further embodiments, the preparation may comprise a combination of the active ingredients, in particular extracts, tinctures, essential oils and / or extracts in liposomally encapsulated and free form. Advantageously, an increase in the effectiveness can be achieved thereby.

Liposomes can form a two-phase system wherein an aqueous phase is entrapped by a lipid phase. The active ingredients, in particular extracts, tinctures, essential oils and / or extracts can thus be enveloped by the lipid phase of the liposomes.

The lipid phase preferably comprises phospholipids. Suitable phospholipids are phosphoglycerides, also called glycerophospholipids, and sphingolipids. Suitable phospholipids are in particular selected from the group of phospholipids frequently occurring in cell membranes, comprising phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and / or sphingomyeline. Also preferred are phospholipids of natural origin, for example from soy or egg, in particular phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, phosphatidylserine and phosphatidic acid. These are also useful in, for example, by catalytic hydrogenation in different degrees of hydrogenation chemically modified form. Also useful are synthetic and semi-synthetic phospholipids such as di-palmitoyl-phosphatidylcholine, di-stearoyl-phosphatidylcholine, stearoyl-palmitoyl-phosphatidylcholine, di-palmitoyl-phosphatidylethanolamine, di-stearoyl-phosphatidylethanolamine, di-myristoyl-phosphatidylserine and / or di-oleyl- phosphatidylcholine.

Suitable compositions of phospholipids may also be added with a proportion of small amounts of other lipids or lipid classes such as neutral lipids, glycolipids and / or sphingomyelin.

Suitable liposomes can be prepared in particular from glycerophospholipids, cholesterol and stearylamine and at least one lipid derivative. Furthermore, amphiphilic compounds such as alkylcarboxylic acids can also be used as membrane-forming substances.

Other lipids in which the extracts, tinctures, essential oils and / or extract extract may dissolve include olive oil, corn oil and soybean oil.

The preparation according to the invention may be in the form of an ointment, cream, gel or lotion. Preparations according to the invention for external use, preferably for application to the skin, are preferably used. It is inventively preferred that the preparation is present as an ointment, cream or gel.

For the purposes of this invention, the term "ointment" is understood to mean a single-phase or multiphase, semi-solid dosage form for use on the skin or mucous membranes, depending on its water content, hydrophobic ointments, water-absorbing ointments and hydrophilic ointments. Pharmaceutically creams and gels are to be distinguished from it. For the purposes of this invention, the term "cream" is understood to mean a multiphase, semisolid preparation of a hydrophilic and a lipophilic component. For the purposes of this invention, the term "gel" is understood to mean a liquid gelled with the aid of swelling substances.

Depending on the basis of the preparation used, the preparation comprises liquid-form extracts, tinctures and / or extracts or their dry matter, in particular arnica and / or comfrey. For example, gels, especially hydrogels, can absorb much more liquid extracts than ointments without segregating the phases. Ointments therefore preferably contain the dry substance obtainable from the liquid-shaped extracts, tinctures and / or extracts, in particular dry extracts. In also preferred embodiments, the preparation therefore comprises extracts of plants and / or plant parts of arnica (Arnica montana) and / or comfrey (Symphytum officinale) in the form of dry extracts. In still further preferred embodiments, the preparation comprises an arnica (Arnica montana) and / or rosemary (Rosmarinus officinalis) essential oil or its dry substance.

It is particularly preferred according to the invention that the preparation is present as an ointment, in particular in the form of a hydrophilic ointment, particularly preferably in the form of a hydrous hydrophilic ointment. Creams are also to be used with advantage in the context of the present invention. Advantageously, a hydrous hydrophilic ointment (Unguentum emulsificans aquosum) is a very water-containing, for example, up to 70% water, and thus not so greasy hydrophilic ointment.

It is further preferred according to the invention that the preparation is in the form of hydrophilic or amphiphilic creams or hydrophilic gels. Furthermore, cooling ointments are also usable. Hydrophilic gel preparations as well as hydrophilic ointments and hydrophilic creams can have a cooling effect. Advantageously, this can enhance the positive, in particular the decongestant, effect of the preparation. Creams, preferably hydrophilic creams and / or amphiphilic creams, are also particularly preferred in the context of the present invention.

Useful ointment, cream and gel bases are described for example in the pharmacopoeias Deutsches Arzneibuch, DAB, or Homeopathic Pharmacopoeia, HAB. It is preferred according to the invention that the preparation comprises, as ointment, cream or gel base, DAB or DAC components (DAC: Deutscher Arzneimittelcodex). Preferred ingredients are, for example, wool wax alcohols, cetylstearyl alcohol, vaseline, preferably white vaseline, cetyl palmitate, waxes, artificial waxes, paraffins, vegetable oils, soapsonic esters, polysorbate, glycerol, monoglycerides, glycerol monostearate 60, macrogol 1000 glycerol monostearate, macrogol 20 glycerol monostearate, fatty alcohols , Cetyl alcohol, medium chain triglycerides, propylene glycol and / or cellulose derivatives. Glycerol monostearate 60, macrogol 1000 glycerol monostearate, macrogol 20-glycerol monostearate, cetyl alcohol, medium-chain triglycerides, white vaseline and / or propylene glycol are particularly preferred according to the invention.

• a. im Bereich von ≥ 2% bis ≤ 40%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Arnika (Arnica montana) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• b. im Bereich von ≥ 1,5% bis ≤ 40%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen und/oder Extrakte von Pflanzen oder Pflanzenteilen von Beinwell (Symphytum officinale) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• c. im Bereich von ≥ 0,5% bis ≤ 20%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis) oder deren Trockensubstanz, insbesondere ätherisches Öl,

wobei die Gehalte der jeweiligen Komponenten so gewählt sind, dass der Gesamtgehalt der Komponenten 100% nicht übersteigt, und als Salben-, Creme- oder Gelgrundlage DAB- oder DAC-Bestandteile.In preferred embodiments, the preparation comprises as active ingredients the following extracts, tinctures, essential oils and / or extracts:

• a. in the range of ≥ 2% to ≤ 40%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or plant parts of arnica (Arnica montana) or their dry matter, in particular dry extract;
• b. in the range of ≥ 1.5% to ≤ 40%, based on the total content of the preparation, extracts, tinctures and / or extracts of plants or plant parts of comfrey (Symphytum officinale) or their dry matter, in particular dry extract;
• c. in the range of ≥ 0.5% to ≤ 20%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or plant parts of rosemary (Rosmarinus officinalis) or their dry matter, in particular essential oil,

wherein the contents of the respective components are selected so that the total content of the components does not exceed 100%, and as an ointment, cream or gel base DAB or DAC ingredients.

It is preferable that the preparation has a hydrophilic base after DAC, in particular, hydrophilic ointments and creams on a DAC basis are preferable. It is particularly preferred according to the invention that the preparation comprises as a basis base cream DAC.

An advantage of using a base cream DAC is that it is pleasant to distribute on the skin. In particular, the preparation can be based on a base cream DAC already when rubbing into the skin. Thus, the formation of a fatty film on the skin is advantageously avoided. Preferably, shortly after the application of a preparation based on a base cream DAC on the skin, the preparation may be drawn in completely or almost without residue. In addition, preparations using a base cream DAC can in particular also show a faster onset of action. These are thus very well suited for the treatment of acute swelling in an advantageous manner. A rapid absorption into the skin also allows a repeated application or a more frequent rubbing. This is a big advantage over a slower oily ointment.

It is further preferable that the preparation has a hydrophilic base after DAB, in particular, a hydroxyethyl cellulose gel DAB is preferable. An advantage of using a hydroxyethyl cellulose gel is that it has a high water content, as a result of which the preparation can advantageously also have a cooling effect. In particular, the use of hydrophilic gels which can combine an improved effectiveness with a skin-cooling effect according to the invention is advantageous. In further embodiments, it is preferred that the ointment, cream or gel base further comprises substances having a skin-cooling effect, for example menthol.

Advantageously, preferred embodiments of the preparation rapidly enter the skin and preferably do not form a greasy film on the skin. Furthermore, preferred embodiments of the preparation have no side effects. Furthermore, the preparation is advantageously stable and shows no segregation even after prolonged storage. Particularly preferred embodiments of the preparation according to the invention preferably also show no segregation and / or no crystal growth after one year of storage and preferably no or negligible change in appearance, color, odor and / or pH.

Furthermore, the preparation may comprise further customary auxiliaries of ointment, cream and / or gel preparation. The pharmaceutical preparation according to the invention preferably also comprises dyes, for example curcumin, curcuma root extract, riboflavin and / or β-carotene.

Furthermore, it is preferred that the preparation is ready for use. For the purposes of the present invention, "ready-to-use" means that the preparation is present as a ready-to-use ointment, cream or gel which can be applied to the skin.

• a. 15% Extrakt oder ätherisches Öl von Pflanzen oder Pflanzenteilen von Arnika (Arnica montana);
• b. 15% Extrakt von Pflanzen oder Pflanzenteilen von Beinwell (Symphytum officinale);
• c. 5% ätherisches Öl von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis);
• d. 65% Hydroxyethylcellulosegel DAB.

In a particularly preferred embodiment, the preparation comprises, based on the total content of the preparation:

• a. 15% extract or essential oil of plants or plant parts of arnica (Arnica montana);
• b. 15% extract of comfrey plants or parts of plants (Symphytum officinale);
• c. 5% essential oil of plants or plant parts of rosemary (Rosmarinus officinalis);
• d. 65% hydroxyethyl cellulose gel DAB.

• a. im Bereich von ≥ 2% bis ≤ 15%, vorzugsweise im Bereich von ≥ 5% bis ≤ 15% Extrakt oder ätherisches Öl von Pflanzen oder Pflanzenteilen von Arnika (Arnica montana);
• b. im Bereich von ≥ 1,5% bis ≤ 15%, vorzugsweise im Bereich von ≥ 5% bis ≤ 15% Extrakt von Pflanzen oder Pflanzenteilen von Beinwell (Symphytum officinale);
• c. 5% ätherisches Öl von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis);
• d. im Bereich von ≥ 65% bis ≤ 91,5%, vorzugsweise im Bereich von ≥ 65% bis ≤ 85% Hydroxyethylcellulosegel DAB.

Also advantageously used are concentrated extracts which have a smaller volume. In a further preferred embodiment, the preparation comprises, based on the total content of the preparation:

• a. in the range of ≥ 2% to ≤ 15%, preferably in the range of ≥ 5% to ≤ 15% extract or essential oil of plants or plant parts of arnica (Arnica montana);
• b. in the range of ≥ 1.5% to ≤ 15%, preferably in the range of ≥ 5% to ≤ 15% extract of comfrey plants or parts of plants (Symphytum officinale);
• c. 5% essential oil of plants or plant parts of rosemary (Rosmarinus officinalis);
• d. in the range of ≥ 65% to ≤ 91.5%, preferably in the range of ≥ 65% to ≤ 85% hydroxyethyl cellulose gel DAB.

• a. Trockenextrakt von 15% ethanolischem Extrakt von Pflanzen oder Pflanzenteilen von Arnika (Arnica montana);
• b. Trockenextrakt von 15% ethanolischem Extrakt von Beinwell (Symphytum officinale);
• c. 5% ätherisches Öl von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis);
• d. ad 100% Basiscreme DAC.

In a further particularly preferred embodiment, the preparation comprises, based on the total content of the preparation:

• a. Dry extract of 15% ethanolic extract of plants or plant parts of arnica (Arnica montana);
• b. Dry extract of 15% comfrey extract of comfrey (Symphytum officinale);
• c. 5% essential oil of plants or plant parts of rosemary (Rosmarinus officinalis);
• d. ad 100% base cream DAC.

The preparations preferably have no side effects, advantageously rapidly enter the skin and preferably do not form a greasy film on the skin. Furthermore, the preparations have a very good action against swelling and pain, are stable and show no segregation even after prolonged storage.

Surprisingly, it has been found that the preparation according to the invention can advantageously have a good efficacy in rheumatic diseases, in particular in the symptomatic treatment of rheumatic pain, or in acute joint inflammation. Preferred embodiments of the preparation according to the invention can advantageously show an improved perfusion-promoting, regenerating and anti-inflammatory action. Likewise, the preparation according to the invention can contribute to the support of tissue regeneration. Furthermore, the preparation according to the invention can show an analgesic effect. This is particularly advantageous in the symptomatic treatment of rheumatic pain.

Furthermore, the preparation of the invention may also have a good decongestant and analgesic effect. This is particularly useful in the treatment of dislocations, dull trauma such as sprains, bruises, strains, bruises or bruises, swelling, muscle and joint pain, for example due to blunt injuries, especially in blunt sports injuries or tired legs advantage.

Another aspect of the present invention relates to the use of a preparation according to the invention for the preparation of a cosmetic or pharmaceutical agent for the treatment of dislocations, dull trauma such as sprains, bruises, strains, bruises or bruises, swelling, muscle and joint pain, for example due to blunt injuries Symptomatic treatment for rheumatic pain, acute joint inflammation, blunt sports injuries or tired legs.

Preferably, the preparation is applied two to three times a day on the affected skin or joints.

Furthermore, the preparation according to the invention is also advantageously suitable for invigorating massage of stressed and tired legs. In particular, the preparation according to the invention can also be advantageously used for the long-term treatment of bruises, strains, bruises and bruises as well as broken bones and after operations.

• a. im Bereich von ≥ 2% bis ≤ 40%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Arnika (Arnika montana) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• b. im Bereich von ≥ 1,5% bis ≤ 40%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen und/oder Extrakte von Pflanzen oder Pflanzenteilen von Beinwell (Symphytum officinale) oder deren Trockensubstanz, insbesondere Trockenextrakt;
• c. im Bereich von ≥ 0,5% bis ≤ 20%, bezogen auf den Gesamtgehalt der Zubereitung, Auszüge, Tinkturen, ätherische Öle und/oder Extrakte von Pflanzen oder Pflanzenteilen von Rosmarin (Rosmarinus officinalis),

wobei die Gehalte der jeweiligen Komponenten so gewählt sind, dass der Gesamtgehalt der Komponenten 100% nicht übersteigt.Another object of the present invention relates to a rheumatism and / or sports ointment. The rheumatism and / or sports ointment comprises as active ingredients the following extracts, tinctures, essential oils and / or extracts:

• a. in the range of ≥ 2% to ≤ 40%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or plant parts of arnica (Arnica montana) or their dry matter, in particular dry extract;
• b. in the range of ≥ 1.5% to ≤ 40%, based on the total content of the preparation, extracts, tinctures and / or extracts of plants or plant parts of comfrey (Symphytum officinale) or their dry matter, in particular dry extract;
• c. in the range of ≥ 0.5% to ≤ 20%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or parts of plants of rosemary (Rosmarinus officinalis),

wherein the contents of the respective components are chosen so that the total content of the components does not exceed 100%.

The rheumatism and / or sports ointment preferably comprises the active ingredients together with harmless, in particular pharmacologically acceptable ointment, cream or gel bases, the description of which is referred to in the foregoing description. The rheumatism and / or sports ointment may also be present as a cream or gel.

For the extracts, tinctures and / or extracts of plants and / or plant parts of comfrey (Symphytum officinale) and / or extracts, tinctures, essential oils and / or extracts of arnica (Arnica montana) and rosemary (Rosmarinus officinalis) is referred to the above Description Reference.

The preparations according to the invention can be prepared by customary processes. Preferably, the extracts, tinctures, essential oils and / or extracts in ointment, cream or gel bases comprising DAB or DAC ingredients, preferably base cream DAC, a. Extracts, tinctures, essential oils and / or extracts may also be liposomally encapsulated.

Examples of preparations which serve to illustrate the present invention are given below. Example 1 Formulation for a preparation in the form of a hydrogel ingredients Vol .-% Amica montana, dried flowers, extract with 70% ethanol, DEV 1:10 15 Symphytum officinale, root / subterranean parts, ethanolic extract 50%, DEV 1:10 15 Rosemary aetheroleum 5 Hydroxyethyl cellulose gel DAB 65

The formulation includes ethanolic extracts of Arnica montana and Symphytum officinale and rosemary essential oil in a gel base of hydroxyethyl cellulose gel.

Example 2

The effect of the invention described in Example 1 above

Preparation was observed in patients with bruises, with the gel being applied to the affected joints and skin areas three times a day.

It was found that by using the preparation according to the invention according to Example 1 a good analgesic and circulation-promoting, regenerating and anti-inflammatory action could be achieved. Even after repeated application of the gel, no contraindications or side effects were observed. Example 3 Formulation for a preparation in the form of an ointment ingredients Vol .-% Arnica montana, dried flowers, extract with 70% ethanol, DEV 1:10 Dry extract of 15% by volume of ethanolic extract Symphytum officinale, root / subterranean parts, ethanolic extract 50%, DEV 1:10 Dry extract of 15% by volume of ethanolic extract Rosemary aetheroleum 5 Base cream DAC ad 100

The formulation included dry extract of 15% by volume of ethanolic extract of Arnica montana and Symphytum officinale and rosemary essential oil in an ointment base of DAC base cream.

Example 4

The effect of the invention described in Example 3 above

Preparation has been observed in patients with rheumatic diseases, with the cream being applied to the rheumatism-affected joints and skin on the wrist, shoulder, knee or hip three times a day.

It was found that the use of the preparation according to the invention according to Example 3 a good pain-relieving and circulation-promoting, regenerating and anti-inflammatory effect could be achieved. Even with repeated application of the ointment no contraindications or side effects were observed. The cream was already absorbed when rubbed into the skin and left no greasy film on the skin.

The preparation of the invention led in particular in the symptomatic treatment of rheumatic pain to an impressive improvement in symptoms. It was possible to achieve a comparably good effect in comparison with known preparations, with fewer side effects occurring.

Claims (9)

Preparation for topical use, in particular in the case of rheumatic diseases, characterized in that the preparation comprises as active ingredients the following extracts, tinctures, essential oils and / or extracts: a. in the range of ≥ 2% to ≤ 40%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or plant parts of arnica (Arnica montana) or their dry matter; b. in the range of ≥ 1.5% to ≤ 40%, based on the total content of the preparation, extracts, tinctures and / or extracts of plants or parts of plants of comfrey (Symphytum officinale) or their dry matter; c. in the range of ≥ 0.5% to ≤ 20%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or plant parts of rosemary (Rosmarinus officinalis) or their dry matter, the contents of the respective components are chosen so that the total content of the components does not exceed 100%. A preparation according to claim 1, characterized in that the preparation comprises as active ingredients the following extracts, tinctures, essential oils and / or extracts: a. in the range of ≥ 5% to ≤ 20%, based on the total content of the preparation, preferably 15% extracts, tinctures, essential oils and / or extracts of plants or plant parts of arnica (Arnica montana) or their dry matter; b. in the range of ≥ 5% to ≤ 20%, based on the total content of the preparation, preferably 15% extracts, tinctures and / or extracts of plants or plant parts of comfrey (Symphytum officinale) or their dry matter; e. in the range of ≥ 1% to ≤ 10%, preferably 5% extracts, tinctures, essential oils and / or extracts of plants or plant parts of rosemary (Rosmarinus officinalis) or their dry matter, wherein the contents of the respective components are chosen so that the total content of the components does not exceed 100%. Preparation according to claim 1 or 2, characterized in that the preparation comprises extracts, tinctures and / or extracts of comfrey root and / or extracts, tinctures, essential oils and / or extracts of Arnica blossom and from the aerial parts of rosemary. Preparation according to one of the preceding claims, characterized in that the preparation comprises alcoholic, aqueous, or aqueous-alcoholic extracts of plants and / or plant parts of arnica (Arnica montana) and comfrey (Symphytum officinale) and an essential oil of rosemary (Rosmarinus officinalis). Preparation according to one of the preceding claims, characterized in that the preparation extracts, tinctures, essential oils and / or extracts in liposomal encapsulated form. Preparation according to one of the preceding claims, characterized in that the preparation is present as an ointment, cream, gel or lotion, preferably in the form of a hydrophilic ointment, in particular in the form of a hydrous hydrophilic ointment. Preparation according to one of the preceding claims, characterized in that the preparation as an ointment, cream or gel base DAB or DAC ingredients, in particular hydroxyethyl cellulose comprises. Use of a preparation according to any one of the preceding claims for the preparation of a cosmetic or pharmaceutical agent for treatment of dislocations, blunt trauma such as sprains, bruises, strains, bruises or bruises, swelling, muscle and joint pain, for example due to blunt injuries, for symptomatic treatment in rheumatic Pain, acute joint inflammation, blunt sports injuries or tired legs. Rheumatoid and / or sports ointment comprising, as active ingredients, the following extracts, tinctures, essential oils and / or extracts: a. in the range of ≥ 2% to ≤ 40%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or plant parts of arnica (Arnica montana) or their dry matter; b. in the range of ≥ 1.5% to ≤ 40%, based on the total content of the preparation, extracts, tinctures and / or extracts of plants or parts of plants of comfrey (Symphytum officinale) or their dry matter; c. in the range of ≥ 0.5% to ≤ 20%, based on the total content of the preparation, extracts, tinctures, essential oils and / or extracts of plants or parts of plants of rosemary (Rosmarinus officinalis), wherein the contents of the respective components are chosen so that the total content of the components does not exceed 100%.