CN109394815A - A kind of infant's skin tonic composition and preparation method thereof - Google Patents
A kind of infant's skin tonic composition and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of infant's skin tonic composition, each component including following mass percent: pot marigold tincture 3-10%, glycerol 10-20%, stearic acid 5-10%, 30% sodium hydroxide solution 5-10%, saualane 5-10%, pure water 40-70%.Infant's skin tonic composition, main component are pot marigold tincture, are the main component of calendula extract, and be aided with glycerol, and stearic acid sodium and saualane are not stimulated mildly, had no toxic side effect, and treatment infant eczema is quick, good effect.
Description
Technical field
The present invention relates to eczema treatment technical fields, and in particular, to a kind of infant's skin tonic composition and its system
Preparation Method.
Background technique
Infant eczema is commonly called as infantile eczema, is a kind of common, allergic skin inflammation as caused by internal and external factor.Symptom
Mostly based on chronic repeatability itch, influence to sleep.It is often spy with the chronic recurrent dermatitis of the sides in the wrong such as fossa cubitalis, popliteal nest
Sign, to occur intensive grain grain size papule, papulo-vesicle or blister on the basis of erythema, blister forms rotten to the corn face after breaking for initial damage,
There is serosity exudation, forms a scab.Acute eczema is dealt with improperly, and subacute or chronic eczema can be switched to, and such as appropriate treatment in time can be by
It gradually improves, but easy to recur.Large stretch of erythema can occur for severe one, be thereon papule in groups, papulo-vesicle, blister, erosive exudating, surface has
Thick scab can also extend to entire Head And Face or incidence.There is erythematous papules, papulo-vesicle, blister, conscious itch in perilesional.It wipes
It is broken that rotten to the corn, incrustation can occur, there is fester exudation under scab, there are pimple, regional glandular enlargement, tenderness in edge.Nearby or it is far apart
Position can also have parallel line shaped erythema, papule and blister caused by scratching.Infant eczema hinders normal growth and development and health.
The treatment of this disease is generally treated using the prevention and treatment method for oral administration applied outside at present, and is clinically often contained in externally applied drug
Glucocorticoids medicine or group amine antiallergic, side effect is more, easily leads to whole body or local adverse reaction, and treat number of days
It cannot be too long.Infant skin immunity is poor, and hormone medicine side effect is more, and easy to recur after drug withdrawal.Such as part hydrocortisone
Class drug will lead to thinning of skin, generate the side effects such as dry skin, atrophy, telangiectasis, pigmentation, even more serious
There may be the inhibition of hypothalamus-pituitary-adrenal axis by person, or growth inhibition phenomena, the unsuitable large dosage of infant, big face occur
Product is used for a long time.Therefore it is badly in need of development efficacy drug or skin care item good, without hormone, the treatment infant eczema having no toxic side effect.
Summary of the invention
For overcome the deficiencies in the prior art, the present invention provides a kind of infant's skin tonic compositions, mainly at
It is divided into pot marigold tincture, is the main component of calendula extract, and is aided with glycerol, stearic acid sodium and saualane do not stimulate mildly,
It has no toxic side effect, treatment infant eczema is quick, good effect.
Technical scheme is as follows: a kind of infant's skin tonic composition, including each of following mass percent
Component: pot marigold tincture 3-10%, glycerol 10-20%, stearic acid 5-10%, 30% sodium hydroxide solution 5-10%, saualane 5-
10%, pure water 40-70%.
Preferably, infant's skin tonic composition, each component including following mass percent: pot marigold tincture 3-
8%, glycerol 12-17%, stearic acid 6-8%, 30% sodium hydroxide solution 6-9%, saualane 5-8%, pure water 50-68%.
Preferably, infant's skin tonic composition, each component including following mass percent: pot marigold tincture
4.4%, glycerol 15%, stearic acid 8%, 30% sodium hydroxide solution 6%, saualane 7%, pure water 59.6%.
The preparation method of infant's skin tonic composition, includes the following steps:
(5) it is weighed by formula each component；
(6) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(7) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(8) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
The pot marigold tincture oil contains " carotenoid " race substance --- and lutein also contains luteole, mineral phosphor
With vitamin C etc., there is real antioxidation, linoleic acid and carrotene abundant can improve sensitive skin, have
Releive, reduce swelling, antibacterial, anti-inflammatory and other effects, improve wrinkle, black eye, sunburn, frostbite, bruise, diaper rash, whelk and mark,
The skin of microfilament exposed vessel.To skin have well moisten and Regeneration and Repair effect, can delaying skin aging, pre- anti-melanin
It is calm.It also have the function of it is preferable it is anti-inflammatory, promote wound healing and maintenance mark, therefore be often used in wound care or
Handle the skin problems such as sunburn, frostbite, whelk wound, eczema, mark.Pot marigold tincture has anti-corrosion, and anti-inflammatory effect is suitble to
Incised wound, burn, the symptoms such as ulcer.
The glycerol has the function of moisturizing.
The stearic acid can prevent from aoxidizing, so that skin nourishment composition generates pearly gloss
30% sodium hydroxide solution has disinfection water suction, the effect of moisturizing.In the application, 30% sodium hydroxide solution
It is reacted with stearic acid, neutralizes skin nourishment composition pH, stimulate product mildly not.
The saualane is the squalene extracting haveing excellent performance.Scientific research discovery, saualane is rare chemical stability
Height, the splendid animal fat of use feeling have preferable compatibility to skin, will not cause allergy and stimulation, and can accelerate formula
Middle other active components are permeated into skin；With lower polarity and medium spreadability, and pure, colourless, free from extraneous odour；Also
It can inhibit the growth of mould.
The pure water is the solvent of other each components, is played the role of with moisturizing.In order to make infant's skin
Tonic composition becomes combination agent, contains vaseline, rubber, rosin, zinc oxide etc..
The invention has the benefit that experiment shows infant's skin tonic composition of the present invention for treating
Infant eczema 1-5 days or so visible good efficacies, do not stimulate mildly, have no toxic side effect, be worthy of popularization.
Specific embodiment
In order to make goal of the invention of the invention, technical solution and technical effect are more clearly understood, below with reference to specific reality
Applying mode, the present invention is described further.It should be understood that specific embodiment described herein, for explaining only the invention,
It is not intended to limit the present invention.
Embodiment 1, a kind of infant's skin tonic composition, each component including following mass percent: pot marigold tincture
3%, glycerol 5%, stearic acid 5%, 30% sodium hydroxide solution 8%, saualane 9%, pure water 70%.
The preparation method of infant's skin tonic composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
Embodiment 2, a kind of infant's skin tonic composition, each component including following mass percent: pot marigold tincture
5%, glycerol 18%, stearic acid 5%, 30% sodium hydroxide solution 5%, saualane 5%, pure water 62%.
The preparation method of infant's skin tonic composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
Embodiment 3, a kind of infant's skin tonic composition, each component including following mass percent: pot marigold tincture
10%, glycerol 20%, stearic acid 10%, 30% sodium hydroxide solution 10%, saualane 10%, pure water 40%.
The preparation method of infant's skin tonic composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
A kind of infant's skin tonic composition of embodiment 4, each component including following mass percent: pot marigold tincture
3%, glycerol 12%, stearic acid 6%, 30% sodium hydroxide solution 6%, saualane 5%, pure water 68%.
The preparation method of infant's skin tonic composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
A kind of infant's skin tonic composition of embodiment 5, each component including following mass percent: pot marigold tincture
8%, glycerol 17%, stearic acid 8%, 30% sodium hydroxide solution 9%, saualane 8%, pure water 50%.
The preparation method of infant's skin tonic composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
A kind of infant's skin tonic composition of embodiment 6, each component including following mass percent: pot marigold tincture
5%, glycerol 15%, stearic acid 7%, 30% sodium hydroxide solution 7%, saualane 6%, pure water 58%.
The preparation method of infant's skin tonic composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
A kind of infant's skin tonic composition of embodiment 7, each component including following mass percent: pot marigold tincture
4.4%, glycerol 15%, stearic acid 8%, 30% sodium hydroxide solution 6%, saualane 7%, pure water 59.6%.
The preparation method of infant's skin tonic composition, includes the following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
Clinical trial is carried out to infant's skin tonic composition of embodiment 1-7.
One, subject
Choose 240 eczema infant patients, be equally divided into 8 groups, every group of men and women is fifty-fifty, each group the age, surname not, the course of disease
Etc. there are no significant difference.
Two, given the test agent, application method
Given the test agent is infant's skin tonic composition of embodiment 1-7, and uses 999 baby's Asian puccoon skin nourishment groups
Close object (three nine-day periods after the winter solstice medicine company) as a control group.
Application method: affected part is put on the skin with the painting of skin nourishment composition, 3 times a day, 7 days as a course for the treatment of, deactivates during treatment
Other drugs.It is paid a return visit after using 1 month and 3 months respectively.
Three, evaluation of clinical curative effect standard
1, cure: the clinical symptoms such as fash, red pimple, erythema, small water scar, the yellow scales of skin that peel off and silly skin, exudation, erosion are whole
It disappears, physical rehabilitation；
2, effectively: clinical symptom relief, improvement；
3, invalid: symptom is compared with pre-treatment without improvement.
Four, result on trial is analyzed
The results are shown in Table 1.Subject tries out the infant's skin tonic composition and infant's skin of embodiment 1-7
During tonic composition, do not occur adverse reaction, 999 baby's Asian puccoon skin tonic compositions of control group occur slight
Adverse reaction.Infant's skin tonic composition of the invention has preferable association due to the pharmaceutical composition of its active constituent
Same synergistic effect, cure rate is high, is much higher than control group.Wherein the effect of embodiment 7 is best, after trying out 1 course for the treatment of, total effective rate
Reach 100%.The recovery from illness patient of embodiment 1-7 is paid a return visit respectively behind 1 month and 3 months, no case was recurrence.
1 infant's skin tonic composition clinical effect trial result of table
| Grouping | Recovery from illness/example | Effectively/example | In vain/example | Adverse reaction/example |
| Embodiment 1 | 20 | 8 | 2 | 0 |
| Embodiment 2 | 19 | 7 | 3 | 0 |
| Embodiment 3 | 21 | 5 | 4 | 0 |
| Embodiment 4 | 21 | 8 | 1 | 0 |
| Embodiment 5 | 23 | 7 | 0 | 0 |
| Embodiment 6 | 25 | 5 | 0 | 0 |
| Embodiment 7 | 29 | 1 | 0 | 0 |
| Control group | 10 | 8 | 10 | 2 |
The following are the specific cases in part:
Case 1: baby, female, 6 months.Describe according to baby mother: there is erythema, mound in 2 months or so face trunks after baby is raw
Rash, blister, the skin lesions such as erosion occur repeatedly, and companion cry and screamed more than January.It is unobvious through multi-treatment effect.Finally select the present invention real
Apply infant's skin tonic composition of the preparation of example 7, apply three times within the day and put affected part on the skin, after 2 days, left and right face, head it is red
Spot is decorporated, and white scales fall off, and is cured completely after 3 days.
Case 2: child, female, 1.5 years old.Describe according to baby mother: probably there is erythema when 8 months are big in her daughter,
Papule, blister, the eczemas symptom such as erosion are often cry and screamed more than.It is unobvious through multi-treatment effect.Finally select the embodiment of the present invention
Infant's skin tonic composition of 7 preparations, 3 times a day, affected part is put in painting on the skin, is taken effect after 1 day, baby's erythema, papule are decorporated, opened
Incrustation, the white scales of beginning fall off, and after 2 days, fresh skin occurs in the incrustation eczema part that falls off, uses complete to the 3rd day baby's eczema
It is complete to cure.
Case 3: child, male, 8 months.Describe according to baby mother: probably there is milk rash when 6 months big in baby, often
It cries and screams more than.There is intensive grain grain size papule, papulo-vesicle or blister, erythema in forehead, on the face, the positions such as fossa cubitalis, popliteal nest.Through more
Square therapeutic effect is unobvious.The infant's skin tonic composition for finally embodiment of the present invention 7 being selected to prepare, 3 times a day, painting is put on the skin
Affected part is taken effect after 2 days, and baby's erythema, papule decorporate, start incrustation, white scales fall off, after 3 days, the eczema portion that falls off of forming a scab
Existing fresh skin is separated, uses to the 4th day baby's eczema and cures completely.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, architectural form cans be flexible and changeable, can be with derivative series product.It only makes several
Simple deduction or replace all shall be regarded as belonging to present invention scope of patent protection determined by the appended claims.
Claims (4)
1. a kind of infant's skin tonic composition, which is characterized in that each component including following mass percent: pot marigold tincture
3-10%, glycerol 10-20%, stearic acid 5-10%, 30% sodium hydroxide solution 5-10%, saualane 5-10%, pure water 40-
70%.
2. infant's skin tonic composition as described in claim 1, which is characterized in that including each of following mass percent
Component: pot marigold tincture 3-8%, glycerol 12-17%, stearic acid 6-8%, 30% sodium hydroxide solution 6-9%, saualane 5-8%,
Pure water 50-68%.
3. infant's skin tonic composition as claimed in claim 2, which is characterized in that including each of following mass percent
Component: pot marigold tincture 4.4%, glycerol 15%, stearic acid 8%, 30% sodium hydroxide solution 6%, saualane 7%, pure water
59.6%.
4. the preparation method of infant's skin tonic composition as described in any one of claims 1-3, which is characterized in that packet
Include following steps:
(1) it is weighed by formula each component；
(2) pure water is taken, 30% sodium hydroxide solution is poured into pure water, is stirred evenly；
(3) in the mixture obtained by step (2), glycerol, saualane and stearic acid is added, stirs evenly；
(4) pot marigold tincture is added, stirs evenly, infant's skin tonic composition is made.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917053A (en) * | 2019-12-06 | 2020-03-27 | 辉达生物医药（苏州）有限公司 | Anti-inflammatory composition |
| CN116327620A (en) * | 2023-04-12 | 2023-06-27 | 广州芭妍化妆品有限公司 | Calendula skin care oil for infants and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476902A (en) * | 2015-12-10 | 2016-04-13 | 苏州东方之宝生物药业有限公司 | Infantile anti-chap skin cream |
| CN109010236A (en) * | 2018-10-17 | 2018-12-18 | 北京爸爸的选择科技有限公司 | A kind of infant's shampoo used also as bath lotion and preparation method thereof |
| CN109432155A (en) * | 2018-12-07 | 2019-03-08 | 肖文秀 | A kind of infant eczema composition and preparation method thereof |
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2018
- 2018-12-28 CN CN201811626461.4A patent/CN109394815A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476902A (en) * | 2015-12-10 | 2016-04-13 | 苏州东方之宝生物药业有限公司 | Infantile anti-chap skin cream |
| CN109010236A (en) * | 2018-10-17 | 2018-12-18 | 北京爸爸的选择科技有限公司 | A kind of infant's shampoo used also as bath lotion and preparation method thereof |
| CN109432155A (en) * | 2018-12-07 | 2019-03-08 | 肖文秀 | A kind of infant eczema composition and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917053A (en) * | 2019-12-06 | 2020-03-27 | 辉达生物医药（苏州）有限公司 | Anti-inflammatory composition |
| CN116327620A (en) * | 2023-04-12 | 2023-06-27 | 广州芭妍化妆品有限公司 | Calendula skin care oil for infants and preparation method thereof |
| CN116327620B (en) * | 2023-04-12 | 2023-11-07 | 广州芭妍化妆品有限公司 | Calendula skin care oil for infants and preparation method thereof |
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Application publication date: 20190301 |