CN104001059A - Traditional Chinese medicine composition for treating acnes and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating acnes and preparation method and application thereof Download PDFInfo
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- CN104001059A CN104001059A CN201410259123.7A CN201410259123A CN104001059A CN 104001059 A CN104001059 A CN 104001059A CN 201410259123 A CN201410259123 A CN 201410259123A CN 104001059 A CN104001059 A CN 104001059A
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Abstract
The invention provides a traditional Chinese medicine composition for treating acnes. In order to treat the acnes, according to the technical scheme, active constituents of the traditional Chinese medicine composition are obtained by extraction preparation of, by weight, 10 parts to 30 parts of perilla frutescens, 5 parts to 15 parts of lemongrass, 10 parts to 20 parts of vervain and 5 parts to 15 parts of herba leonuri. A tincture is obtained through a corresponding preparation method. The traditional Chinese medicine composition has the effect of treating the acnes.
Description
Technical field
The present invention relates to Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine composition and method for making and application of Acne treatment.
Background technology
Acne is a kind of chronic inflammatory disease dermatoses of pilosebaceous unit, is mainly apt to occur in teenager, very large to teen-age psychology and social influence, but often can naturally alleviate or fully recover after adolescence.Clinical manifestation is to be apt to occur in the pleomorphism skin lesion such as facial acne, pimple, pustule, tuberosity as feature.The factors such as the generation of acne is main stops up with hypersteatosis, pilosebaceous duct, antibacterial infection and inflammatory reaction are closely related.After adolescing in human body androgen particularly the level of testosterone raise rapidly, promote sebaceous gland to grow and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes conduit to stop up simultaneously, dyssebacia, and forming horn plug is micropowder thorn.Especially propionibacterium acnes amount reproduction of multiple-microorganism in hair follicle, the lipase that propionibacterium acnes produces decomposes sebum and generates free fatty, chemotactic inflammatory cell and medium simultaneously, final induction exacerbate inflammation reaction.Existing market is badly in need of a kind of medicine for external use of Acne treatment.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine preparation of Acne treatment.
Another object of the present invention is to provide a kind of Chinese medicine preparation preparation method and application of Acne treatment.
Technical scheme: the object of the invention is to realize by following scheme:
A Chinese medicine composition for Acne treatment, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: Folium Perillae 10-30 part, Herba Cymbopogonis Citrari 5-15 part, Herba Verbenae 10-20 part, Herba Leonuri 5-15 part.
The Chinese medicine composition of above-mentioned Acne treatment, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: 20 parts of Folium Perillaes, 10 parts of Herba Cymbopogonis Citraris, 15 parts of Herba Verbenae, 10 parts of Herba Leonuris.
The Chinese medicine composition of above-mentioned Acne treatment, described crude drug adds substrate and makes tincture after extracting.
The Chinese medicine composition of above-mentioned Acne treatment, described substrate is 75% ethanol 50-70 part.
The method of the Chinese medicine composition of above-mentioned Acne treatment, preparation process is: get Folium Perillae, Herba Cymbopogonis Citrari, Herba Verbenae, the merging of Herba Leonuri medical material, pulverize, make solvent soaking with 75% ethanol, after 5-20 hour, get supernatant, be prepared into tincture, fill.
The preparation method of the Chinese medicine composition of above-mentioned Acne treatment, makes solvent soaking 10 hours with 75% ethanol in step.
The Chinese medicine composition of above-mentioned Acne treatment is in the application of preparing in Retinoids, Retin-A, Renova, Accutane.
Herba Cymbopogonis Citrari is the herb of grass Herba Cymbopogonis, and all the other are pharmacopeia kind.
Find by clinical and experimental study, Chinese medicine composition of the present invention has good Acne treatment effect.Therefore, the present invention also provides the purposes of aforementioned pharmaceutical compositions, and the Chinese medicine composition of above-mentioned Acne treatment is in the application of preparing in Retinoids, Retin-A, Renova, Accutane.
Beneficial effect:
From theory of Chinese medical science, Folium Perillae dispersing wind-cold in we, is monarch drug, Herba Verbenae heat-clearing and toxic substances removing, and Herba Cymbopogonis Citrari is affixed one's name to clearly expelling pathogenic factors from the exterior, and dampness removing stomach function regulating is ministerial drug altogether, and Herba Leonuri blood circulation promoting and blood stasis dispelling, is adjuvant, and inducing sweat and disperse in full side, is used for the treatment of acne.Formulation is reasonable, and compatibility is rigorous.The present invention consists of Chinese crude drug, has no side effect, and low price.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
1,, in conjunction with detailed description of the invention, the present invention is further described as follows:
Embodiment 1: get 20 parts of Folium Perillaes, 10 parts of Herba Cymbopogonis Citraris, 15 parts of Herba Verbenae, 10 parts of medical materials merging of Herba Leonuri, pulverize, make solvent soaking with 60 parts of 75% ethanol, get supernatant after 10 hours, fill.
2, clinical observation and model case:
Physical data: all 14～42 years old case ages, 26.8 years old mean age, the course of disease 2 months-5 years, average course of disease 3 years.Totally 100 examples, adopt random digit method, patient are divided into two groups at random, treatment group 50 examples: wherein male 25 examples, and female's 25 examples, by acne classification level Four improvement staging, point I level acne 12 examples, II level acne 38 examples; Matched group 50 examples: wherein male 22 examples, female's 28 examples, I level acne 24 examples, II level acne 24 examples.Epidemiological Analysis by statistics, above two groups of cases are aspect sex, age, the state of an illness, and difference not statistically significant (P > 0.05), has comparability.
Diagnostic criteria: (1) diagnosis reference " clinical dermatology ", " People's Republic of China's Chinese medicine industry standard-TCM Dermatology disease Standardization of diagnosis and curative effect ": there is typical clinical symptoms and sign, skin lesion is mainly being dispersed in property blackhead, inflammatory pimple, pustule, tuberosity, the cyst of involving facial area, is diagnosed as acne person.(2) exclusion standard: 1. with infectious disease person, as: hepatitis, syphilis, acquired immune deficiency syndrome (AIDS) etc.; 2. can not be on demand timing therapist; 3. the person that accepts other treatment in therapeutic process.
Therapeutic Method: treatment group is used traditional Chinese medicinal lotion of the present invention, washout potion every day, three times on the one; Matched group only gives the external of clindamycin and metronidazole liniment, every day 2 times.Two groups of homogeneous Zhou Weiyi courses for the treatment of.
Criterion of therapeutical effect: formulate " Chinese medicine (new drug) guideline of clinical investigations " with reference to Ministry of Health of the People's Republic of China: recovery from illness: facial acne erythra all disappears, occur without new breakout, only stay pigmentation; Effective: acne deflorescence is more than 70%, and inflammation obviously alleviates, occur without new erythra; Effective: the acne erythra 20%-70% that obviously disappears, has a small amount of new erythra to occur; Invalid: acne erythra obviously disappears 20%, or still have new erythra to occur.
Therapeutic outcome: after treating two courses for the treatment of, add up curative effect, treatment group 50 examples, 23 examples of wherein fully recovering, effective 17 examples, effective 9 examples, invalid 1 example, total effective rate arrives 98%; Matched group 50 examples, 12 examples of wherein fully recovering, effective 14 examples, effective 8 examples, invalid 16 examples, effective percentage reaches 68%.Two groups of cure rates, total effective rate has significant difference (P < 0.05).
Model case:
1, chapter XX, female, 38 years old, the acne course of disease was 6 years, and being dispersed in property of face blackhead, inflammatory pimple, be diagnosed as acne, and the tincture that uses the embodiment of the present invention 1 to prepare, uses 2 months continuously, and the disappearance of all diseases is fully recovered, and follows up a case by regular visits to the half a year of not recurrence again.
2, Lee XX, man 22 years old, the acne course of disease is 2 years, and face has pustule, tuberosity, is diagnosed as acne, and the tincture that uses the embodiment of the present invention 1 to prepare, uses 1.5 months continuously, and the disappearance of all diseases is fully recovered, and follows up a case by regular visits to the half a year of not recurrence again.
Claims (6)
1. a Chinese medicine composition for Acne treatment, is characterized in that, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: Folium Perillae 10-30 part, Herba Cymbopogonis Citrari 5-15 part, Herba Verbenae 10-20 part, Herba Leonuri 5-15 part.
2. the Chinese medicine composition of Acne treatment as claimed in claim 1, is characterized in that, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: 20 parts of Folium Perillaes, 10 parts of Herba Cymbopogonis Citraris, 15 parts of Herba Verbenae, 10 parts of Herba Leonuris.
3. the Chinese medicine composition of Acne treatment as claimed in claim 1, is characterized in that, described crude drug is through soaking and make tincture with substrate, and described substrate is 75% ethanol 50-70 part.
4. the Chinese medicine composition of Acne treatment as claimed in claim 1, is characterized in that, preparation method comprises the steps: to get Folium Perillae, Herba Cymbopogonis Citrari, Herba Verbenae, Herba Leonuri medical material and merges, pulverize, make solvent soaking with 75% ethanol, after 5-20 hour, get supernatant, be prepared into tincture, fill.
5. the Chinese medicine composition of Acne treatment according to claim 4, is characterized in that making solvent soaking 10 hours with 75% ethanol in preparation method step.
As claimed in claim 1 the Chinese medicine composition of Acne treatment in the application of preparing in Retinoids, Retin-A, Renova, Accutane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410259123.7A CN104001059A (en) | 2014-06-11 | 2014-06-11 | Traditional Chinese medicine composition for treating acnes and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410259123.7A CN104001059A (en) | 2014-06-11 | 2014-06-11 | Traditional Chinese medicine composition for treating acnes and preparation method and application thereof |
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| CN104001059A true CN104001059A (en) | 2014-08-27 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815245A (en) * | 2015-04-28 | 2015-08-05 | 淄博齐鼎立专利信息咨询有限公司 | TCM (Traditional Chinese Medicine) composition for treating acne |
| CN104998155A (en) * | 2015-08-12 | 2015-10-28 | 青岛琴诚医药技术有限公司 | Medicinal preparation for treating acne |
| CN111110758A (en) * | 2018-10-31 | 2020-05-08 | 西南民族大学 | Ointment and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411360A (en) * | 2000-03-07 | 2003-04-16 | 雅芳产品公司 | Method of treating skin conditions |
| JP2008019180A (en) * | 2006-07-11 | 2008-01-31 | Shiseido Co Ltd | Lipase inhibitor, horney plug formation inhibitor, pore conspicuousness inhibitor and pimple inhibitor |
-
2014
- 2014-06-11 CN CN201410259123.7A patent/CN104001059A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411360A (en) * | 2000-03-07 | 2003-04-16 | 雅芳产品公司 | Method of treating skin conditions |
| JP2008019180A (en) * | 2006-07-11 | 2008-01-31 | Shiseido Co Ltd | Lipase inhibitor, horney plug formation inhibitor, pore conspicuousness inhibitor and pimple inhibitor |
Non-Patent Citations (2)
| Title |
|---|
| 小径: "《女性形体保健美容常识与禁忌》", 30 November 2004, 中国纺织出版社 * |
| 石原结实: "《身体暖暖就能瘦》", 31 March 2012, 中信出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815245A (en) * | 2015-04-28 | 2015-08-05 | 淄博齐鼎立专利信息咨询有限公司 | TCM (Traditional Chinese Medicine) composition for treating acne |
| CN104998155A (en) * | 2015-08-12 | 2015-10-28 | 青岛琴诚医药技术有限公司 | Medicinal preparation for treating acne |
| CN111110758A (en) * | 2018-10-31 | 2020-05-08 | 西南民族大学 | Ointment and application thereof |
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Application publication date: 20140827 |
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