CN106983776A - Silk gum Chinese patent drug - Google Patents

Abstract

A kind of Chinese patent drug, it is characterized in that by silk cocoon or silk after processing, collagen, sericin peptide taken and silk peptide for being extracted from silk cocoon or silk etc. are processed into the various Chinese patent drug formulations such as pill, powder.It can be made into silk gum Chinese patent drug containing single ingredient or the silk gum multi-flavor Chinese patent drug using silk gum as monarch drug in a prescription be made with other Chinese medicine compatibilities.The present invention utilizes silk gum soluble in water or wine, the nutriments such as the abundant amino acid contained in silk gum and medical substance are delivered to each organ of human body, to improve microcirculation in human body, promote cell metabolism, and for suppressing the generation of melanin and the CO2 laser weld of the various wounds caused by traffic accident etc..At the same time, collagen, sericin peptide taken and silk peptide etc. also have antioxidation to human body cell.It is demonstrated experimentally that it can also alleviate and treat the illnesss such as shoulder arthralgia, pain in the back, skelagia.

Description

Silk gum Chinese patent drug

The present invention relates to a kind of Chinese patent drug, more particularly to a kind of silk gum Chinese patent drug.

The Chinese herbal product of various different dosage forms is made through preparation processing mainly using Chinese herbal medicine as raw material for Chinese patent drug, including The various formulations such as ball, scattered, cream, pellet.It is China's successive dynasties medical scholar created by thousands of years of medical practices, summarize have efficacious prescriptions The elite of agent.Chinese patent drug concrete application is divided to two kinds, it is a kind of be narrow sense medically, it is another be broad sense daily life in use 's.Narrow sense Chinese patent drug, it refers mainly to the ready-made medicine for being made up, being taken at any time by principle formula of necessarily curing the disease of Chinese medicine, The Chinese patent drug such as the various pills in Chinese patent drug, powder, electuary, vina, tincture, paste；The Chinese patent drug of broad sense, except including narrow Outside the concept of adopted Chinese patent drug, in addition to all pass through the herbal medicine medicinal material of Preparation process.Chinese medicine is the guidance in theory of traditional Chinese medical science It is lower to be used to prevent, diagnose, treat disease or adjust the medicine of function of human body.Mostly autonomic drug, also there is animal drugs, mineral drug and portion Differentiation is learned, biological drug.The need for being controlled with the accumulation and clinical card of Couple herbs, for a long time, tcm prescription is Development has a variety of for oral administration and externally dressings such as soup, wine, tea, dew, ball, scattered, cream, pellet, piece, ingot, glue, song, and medicated roll, line agent Type.Herein particular it should be pointed that being made for Chinese medicine is inseparable with its concocting method.Chinese medicine have to pass through processing after One of it can be used as medicine, the characteristics of be middle medical drugs.Chinese medicine preparation be according to traditional Chinese medical theory, according to diagnosis and treatment based on an overall analysis of the illness and the patient's condition medication the need for and Medicine self property, and adjustment, the different requirements of preparation, the pharmaceutical technology taken.The processing of Chinese medicine has water preparation method, fire system Method and extreme misery are with preparation method etc..Current Chinese medicine preparation technology enters traditional Chinese medicine preparation using the science and technology of modernization Modernization, the new development of mechanization.This patent includes as above Chinese patent drug, the various concocting methods involved by Chinese medicine and all doses Type.Chinese working people during combating the disease, by practice, gradually have accumulated rich experiences for thousands of years, and And these are gradually recorded, occur in that medical classical works.There is huge contribution for the prosperity of the Chinese nation. Before two thousand yearses《The Yellow Emperor's Canon of Internal Medicine》.And for example《Sheng Nong's herbal classic》《Bencao jizhu》《Tang materia medica》And《Compendium of Materia Medica》 Deng.These immortal works not only have very big influence to the development of China's materia medica, and spread to foreign countries, to world's medicine Significant contribution has been made in development.But, the use of Chinese medicine, due to productivity and the limitation of Sci-Tech Level, in the past in The patent medicine overwhelming majority uses herbal decoction piece, directly use silkworm, silkworm chrysalis, silk cocoon more than such as silkworm class medicine, i.e., these medicines Material is directly processed into various Chinese patent drugs after processing.If Chinese patent drug have left scientific analysis, it can largely increase by one in rain A little probably so to guess or excessive experience composition, therefore people also go no further to the understanding of medicine.So-called silk gum, be A kind of animal collagen extracted from silk cocoon or silk.Silk gum is usually used in cosmetics as NMF material. It can be also a kind of natural food antioxidant as a kind of functional food nourishing additive agent.And silk gum also have change The effects such as kind microcirculation.Silk gum involved by this patent, including silk collagen, sericin peptide taken and silk peptide.And so-called silk gum Chinese patent drug, is the processing such as collagen, sericin peptide taken and silk peptide for therefrom extracting by silk cocoon or silk after processing (water system) A kind of Chinese patent drug being made.

It is an object of the invention to create a kind of silk gum Chinese patent drug, make one to be easy to digest and assimilate the abundant battalion contained in silk gum Support, and improve microcirculation in human body, promote cell metabolism, it may also be used for suppress melanin generation and caused by traffic accident etc. The CO2 laser weld of various wounds.Moreover, silk gum, sericin peptide taken and silk peptide etc. there is very strong antioxygen to be turned into human body cell With.

To reach above-mentioned purpose, silk gum Chinese patent drug of the invention is the Cong Zhongti by silk cocoon or silk after processing (water system) Collagen, sericin peptide taken and silk peptide for taking etc. are processed into the various silks such as pill, powder, electuary, vina, tincture, paste Glue Chinese patent drug formulation.It can be made into silk gum Chinese patent drug containing single ingredient or the multi-flavor Chinese patent drug by monarch drug in a prescription of silk gum.

Early in the Ming Dynasty, Li Shizhen (1518-1593 A.D.)《Compendium of Materia Medica》Etc. recording the medicine that silkworm, silkworm chrysalis, silk cocoon are made in pharmacopeia.Shi Zhen Say：" silk cocoon side's book is used, and all families《Book on Chinese herbal medicine》Do not mention, really lack text.Modern times, with ulcer is controlled for pin, are one with one piece Head, two pieces are two, and the magical effect is incomparable.Boil soup and control and quench one's thirst, ancient prescription is very referred to as.Red small stream Zhu Shi says this thing category fire, has the moon to be used, energy Mutually fire is let out in bladder, is drawn on clear gas towards in mouth, therefore can quench the thirst ".It means that silk cocoon controls carbuncle mystery incomparably, and it is cooked into soup Can also clearing heat-fire quench one's thirst.Ulcer, modern medicine explain its be skin hair follicle and sebaceous glands in groups by caused by bacterium infection Purulent inflammation, its pathogen is staphylococcus, i.e., the tumour caused by infection of staphylococcus aureus.And for example, treasure says when " (silk cocoon) ashing wine takes, and controls that carbuncle swells are without a head, and next day is broken.All infantile malnutrition due to digestive disturbances or intestinalparasites sores, and lower blood blood strangury metrorrhagia are treated again ".It means, processes silkworm Cocoon, which enters wine, can effectively treat redness.A variety of venereal diseases or even lower body massive haemorrhage can also be controlled.Silk gum is the material extracted from silk.Silkworm Silk is made up of two parts, the part referred to as silk gum that its peripheral silk collagen is constituted；The portion that inner core is made up of colloid albumen Divide and be referred to as fibroin.Silk gum accounts for the 20%~30% of silk amount, and silk gum is made up of I, II, III, IV kind of protein from outside to inside.It is overall Molecular conformation is mainly random coil, and spatial configuration of molecules is loose, unordered containing beta structure presence, but without αhelix.Silk gum There are the longer amino acid of many side chains, such as arginine, lysine, glutamic acid, methionine, tryptophan, tyrosine on protein chain Deng 18 kinds of amino acid (polarity pendant amino group acid accounts for total amino acid content (w/w) >=70%), and many polar hydrophilic groups (as- OH、—COOH、—NH2、>NH etc.) it is in polypeptide chain surface.These architectural features assign the excellent damping of sericin, moisturizing Effect.Silk gum has water solubility, is soluble in hot water, acid, aqueous slkali.Lot of domestic and international researcher has many documents to discuss silk Glue.Main direction of studying is the silk gum as skin care item or textile.Silk gum is a kind of NMF material, can effectively be prevented Only scaly dry skin crowfoot cracks aging, suppresses the generation of melanin in skin.Research discovery, the penetration pole of 1. fibroin hydrolyzates By force.Skin skin corium can be penetrated into for 10 seconds or so by being applied to skin, play moisture-keeping function.2. skin bottom can be goed deep into, from basic Upper skin whitening and it is without any side effects；3. can long-acting moisturizing.Silk gum has excellent damping, a moisture-keeping function, the NMF factors (my god Right moisturizing factor) conventional plant or chemical NMF are decupled, continue efficiently to keep the skin wet to skin；4. nourish conditioning.Because of it Penetration is strong, provides required nutrient for skin, promotes cell metabolism, improves skin quality；5. microcirculation can be improved.It can swash Skin cell living, anti-ageing smoothing wrinkle；6. silk gum has the functions such as anti-oxidant, antibacterial anti-corrosion.Resist ultraviolet, daylight, microwave, chemistry The erosion of material, atmosphere pollution to skin；7. the generation of melanin can be suppressed.Researcher has carried out following contrast test： Silk is made 6 according to this after high-temperature high pressure water degumming process, HTHP alkaline water degumming process and neutral proteinase hydrolysis Plant the sericin peptide taken and its hydrolysate of different molecular weight ranges.Sericin peptide taken, which has been carried out, using silkworm 5 age silkworm blood suppresses melanin life Into experiment.Result of study shows that this 6 kinds of sericin peptide takens all have the effect for suppressing melanin generation.HTHP water process is obtained Sericin peptide taken antioxidation it is most strong, the sericin peptide taken antioxidation that the processing of HTHP alkalescent water is obtained is lower slightly, and neutral The inhibiting rate that the sericin peptide taken of protease hydrolytic is formed to melanin is minimum.When the mass fraction of silk gum reaches 0.5%, the first two class silk The inhibiting rate of glue can respectively reach 55% and 50%, and the inhibiting rate that the 3rd class enzymolysis silk gum generate to melanin be 20%~ 25%, the only not enough half of first two.These experimental results illustrate that the sericin of high temperature or the processing of high temperature alkalescent is more suitable Together in the application in the fields such as cosmetics, skin care item, health products.Melanin is spoken of, it is present in the skin or hair of animal A kind of pigment of dark brown, is generated and is stored therein in by a kind of special cell, i.e. melanocyte.Melanoma is more by black Canceration occurs for the mole or melanin spot that chromatophore is formed.Melanoma turns into all malignant tumours in recent years to be sent out The sick fastest-rising malignant tumour of rate, annual growth 3%~5%.Also, malignant mela noma once enters fast growing period, Patient's poor prognosis, case fatality rate are higher.Moreover, sericin powder can be used as a kind of functional nutrient additive for food.Due to silk gum Albumen has preferable antioxygenic property to grease based food, so being a kind of natural food antioxidant.In addition, in recent years It is used for the repairing and treating of the various wounds such as injured nerve, cardiac muscle, skeletal muscle to there is researcher to extract silk gum from silk, i.e., Silk gum is used for the CO2 laser weld of surgical operation.As it was previously stated, sericin peptide taken and silk peptide, there is very strong antioxidation.Antioxygen Change and refer to the abbreviation of resisting oxidation free radical, human body because with extraneous continuous contact, including breathe (oxidation reaction), outside contamination, put The factors such as radiation exposure constantly produce free radical in body.Scientific investigations showed that, such as cancer, aging or Other diseases It is relevant mostly with the generation of excessive free radicals.Research is anti-oxidant can effectively to overcome the harm that it is brought.It should refer to herein Go out, it is a kind of collagen egg that the molecular weight of silk collagen peptide, which is less than collagen molecules amount, especially sericin peptide taken and silk peptide, White precursor product, its mean molecule quantity is about 1000 dalton, so being easier to be digested.This patent is exactly to utilize Silk gum is soluble in water or alcohol, and the nutriments such as the abundant amino acid contained in silk gum and medical substance are delivered into human body Each organ, to improve microcirculation in human body, promote cell metabolism, and for suppressing the generation of melanin and because of traffic accident CO2 laser weld of various wounds etc. Deng caused by.At the same time, collagen, sericin peptide taken and silk peptide etc. are to human body cell Equally there is antioxidation.It is demonstrated experimentally that it can also effectively alleviate and treat the illnesss such as shoulder arthralgia, pain in the back, skelagia.

Claims (3)

1. a kind of Chinese patent drug, it is characterised in that by silk cocoon or silk after processing (water system), the collagen egg extracted from silk In vain, sericin peptide taken and silk peptide etc. are processed into silk gum Chinese patent drug containing single ingredient.

2. the Chinese patent drug according to claims 1, it is characterized in that by silk cocoon or silk after processing (water system), from silk It is various that collagen, sericin peptide taken and silk peptide of extraction etc. are processed into pill, powder, electuary, vina, tincture, paste etc. Chinese patent drug formulation.

3. the Chinese patent drug according to claims 1 and 2, can be made the silk using silk gum as monarch drug in a prescription with other Chinese medicine compatibilities Glue multi-flavor Chinese patent drug.