CN106038423B - A kind of anti-acne, except scar gel and preparation method thereof - Google Patents
A kind of anti-acne, except scar gel and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of anti-acne, except scar gel and preparation method thereof, belongs to cosmetics and skincare product field.The gel is made of the raw material of following weight percent: Chinese herbal medicine extract 0.5-5%, card pool nurse 0.5-2%, water 90-97%, glycerol 0.3-1%, triethanolamine 0.3-1.5%, auxiliary element 0.1-0.3%, the Chinese herbal medicine extract is made of raw material from the following weight: Chinese yam 30-100, Fructus Aurantii 30-100, ginseng 3-30, Radix Salviae Miltiorrhizae 20-80, honeysuckle 10-80, dandelion 10-80, Chinese Ladiestresses Root or Herb 2-10, Calusena lansium core 1-10, muskmelon seed 1-10, daghestan sweetclover herb 1-7, Smilacina japonica 1-5, Phoenix Tree Seed 1-6, Hedge Prinsepia Nut 1-5.The product anti-acne effect is significant, the healing period is short, does not recur, also has effects that except scar, antiallergy, has good inhibiting effect to propionibacterium acnes, also very significant for the whelk patient curative effect of severe.
Description
Technical field
The invention belongs to cosmetics and skincare product fields, and in particular to a kind of anti-acne, except scar gel and preparation method thereof.
Background technique
Whelk is medically called acne, is due to endocrine disturbance, and puberty 3male hormone secretion is vigorous, hair follicle and
Sebaceous glands blocking, bacterial decomposition generate the substances such as fatty acid and cause what tissue inflammation was formed, are mainly in young people.Chinese medicine thinks green
The pathogenic factor of spring acne mainly has damp and hot wind and heat in the lung meridian, stomach, the dysfunction of the spleen in transport, congestion blood block and kidney deficiency and liver.The position sent out well
There are cheek, lower jaw and forehead, some also see the positions such as chest and back.For growing the whelk in face, can be stayed in face
Under serious scar, not only influence beautiful, but also mentally cause great pressure to young people, be easy to produce the heart of feeling oneself inferior
Reason, serious or even influence work, studying and living.
Currently, various for treating the product category of whelk in the market, effect is also irregular, mainly there is anti-acne external application
Medicine and two kinds of anti-acne medicine for oral administration, there is Chinese herbal medicine and two kinds of Western medicine.Anti-acne Western medicine contains antibiotic more, and side effect is larger, to skin
Stimulation it is also big, be easy to produce dependence, take the burden that can aggravate liver kidney for a long time.In anti-acne Chinese herbal medicine, externally applied drug, which exists, to be seen
The problems such as slow, easy to recur is imitated, the problems such as effect is bad, and medicine for oral administration is long there are medication time, slow effect, and quite a few people
Because the big problem of anti-acne Chinese herbal medicine smell for oral administration is difficult to adhere to taking, effect is difficult to embody.Moreover, common product for resolving poxes
In, having only can remove its acne print to the small pox during anti-acne except the product for resolving poxes of acne print function is general, and to leaving before
Acne print and scar removal effect it is poor.Anti-acne method is there are also the operation such as Chemical peeling, physiotherapy, but its somewhat expensive.
Summary of the invention
In view of the defects existing in the prior art, the present invention provides a kind of anti-acne, except scar gel, and the gel anti-acne effect is aobvious
Work, the healing period is short, does not recur, does not stay acne print, but also has effects that except scar, to the scar generated on everyday process skin
With good desalination, removal effect.
The present invention is achieved by the following technical solutions.
A kind of anti-acne removes scar gel, by Chinese herbal medicine extract, card pool nurse, water, glycerol, triethanolamine and auxiliary element group
At the weight percent of each component is as follows: Chinese herbal medicine extract 0.5-5%, card pool nurse 0.5-2%, water 90-97%, glycerol 0.3-
1%, triethanolamine 0.3-1.5%, auxiliary element 0.1-0.3%, it is characterised in that: the Chinese herbal medicine extract is by following parts by weight
Herbal raw material be made: 30-100 parts of Chinese yam, 30-100 parts of Fructus Aurantii, 3-30 parts of ginseng, 20-80 parts of Radix Salviae Miltiorrhizae, honeysuckle 10-80
Part, 10-80 parts of dandelion, 2-10 parts of Chinese Ladiestresses Root or Herb, 1-10 parts of Calusena lansium core, 1-10 parts of muskmelon seed, 1-7 parts of daghestan sweetclover herb, Smilacina japonica 1-5
Part, 1-6 parts of Phoenix Tree Seed, 1-5 parts of Hedge Prinsepia Nut.
Preferably, above-mentioned anti-acne, be made of raw material from the following weight except Chinese herbal medicine extract described in scar gel: mountain
40-80 parts of medicine, 40-80 parts of Fructus Aurantii, 3-20 parts of ginseng, 25-60 parts of Radix Salviae Miltiorrhizae, 20-75 parts of honeysuckle, 10-50 parts of dandelion, interwined dragon
Join 2-8 parts, 2-8 parts of Calusena lansium core, 2-8 parts of muskmelon seed, 1.5-6 parts of daghestan sweetclover herb, 1-3 parts of Smilacina japonica, 2-4 parts of Phoenix Tree Seed, Hedge Prinsepia Nut 1-3
Part.
Preferably, above-mentioned anti-acne, be made of raw material from the following weight except Chinese herbal medicine extract described in scar gel: mountain
45 parts of medicine, 43 parts of Fructus Aurantii, 4 parts of ginseng, 30 parts of Radix Salviae Miltiorrhizae, 37 parts of honeysuckle, 12 parts of dandelion, 3 parts of Chinese Ladiestresses Root or Herb, 3 parts of Calusena lansium core, sweet tea
2 parts of melon seeds, 2 parts of daghestan sweetclover herb, 2 parts of Smilacina japonica, 2 parts of Phoenix Tree Seed, 2 parts of Hedge Prinsepia Nut.
Preferably, above-mentioned anti-acne, except auxiliary element described in scar gel by beta carotene, attar of rose, rose hip oil and
Tween-80 forms, wherein the weight ratio of beta carotene, attar of rose, rose hip oil and Tween-80 are as follows: (1-2): (1-2): (1-
2): (7-20).
A kind of above-mentioned anti-acne, except the preparation method of scar gel, comprising the following steps:
(1) it prepares Chinese herbal medicine extract: weighing Chinese yam, Fructus Aurantii, ginseng, Radix Salviae Miltiorrhizae, honeysuckle, dandelion, Chinese Ladiestresses Root or Herb, Calusena lansium
Core, muskmelon seed, daghestan sweetclover herb, Smilacina japonica, Phoenix Tree Seed, Hedge Prinsepia Nut are decocted twice with water, and the water being added every time is the herbal raw material matter
8 times of amount, each decocting time are 1h, and filtering merges filtrate twice, concentrate the filtrate to and measure its density at 60 DEG C and be
1.2g/cm3 obtains concentrated extract, the addition ethyl alcohol progress alcohol precipitation in concentrated extract, and the weight ratio of concentrated extract and ethyl alcohol is 1:
3, it stands for 24 hours, supernatant is taken to recycle ethyl alcohol, concentration obtains Chinese herbal medicine medicinal extract, as Chinese herbal medicine extract, is in store for；
(2) auxiliary element is weighed, after auxiliary element is mixed, is dissolved in water, it is spare；
(3) card pool nurse is weighed, 4h is soaked in water, is sufficiently swollen, it is spare；
(4) it mixes: the product of the Chinese herbal medicine extract that step (1) is obtained and the product of step (2) addition step (3)
In, it stirs evenly, glycerol and remaining water is added, triethanolamine is added, it stirs evenly；
(5) it packs: encapsulating, packaging.
The invention has the following advantages that
Anti-acne provided by the invention, except scar gel anti-acne effect is significant, cures that the period is short, do not recur, does not stay acne print, for
The whelk patient curative effect of severe is also very significant, but also has effects that except scar, to what is generated on skin in everyday process
Scar has good desalination, removal and repair.The gel also has effects that antiallergy, has to propionibacterium acnes simultaneously
There is good inhibiting effect, can effectively prevent the case where whelk patient aggravates the state of an illness because of skin allergy.The present invention provides
Anti-acne, except scar gel process for preparing it is simple, it is easy to use, be applied to affected part, taste is small, does not affect the appearance.
Specific embodiment
Embodiment 1
1. a kind of anti-acne removes scar gel, it is made of following weight raw material:
Chinese herbal medicine extract 2g is made of following herbal raw material: Chinese yam 45g, 43 g of Fructus Aurantii, 4 g of ginseng, Radix Salviae Miltiorrhizae
30 g, 37 g of honeysuckle, 12 g of dandelion, Chinese Ladiestresses Root or Herb 3g, 3 g of Calusena lansium core, 2 g of muskmelon seed, 2 g of daghestan sweetclover herb, 2 g of Smilacina japonica, Chinese parasol tree
2 g of the seeds of a tung oil tree, 2 g of Hedge Prinsepia Nut；
Card pool nurse 1.4g；
Water 94.64g；
Glycerol 0.7g；
Triethanolamine 1g；
Auxiliary element 0.26g, wherein beta carotene 0.02g, attar of rose 0.02g, rose hip oil 0.02g and Tween-80
0.2g。
A kind of anti-acne, except the preparation method of scar gel, comprising the following steps:
(1) prepare Chinese herbal medicine extract: weigh the Chinese yam of above-mentioned weight, Fructus Aurantii, ginseng, Radix Salviae Miltiorrhizae, honeysuckle, dandelion,
Chinese Ladiestresses Root or Herb, Calusena lansium core, muskmelon seed, daghestan sweetclover herb, Smilacina japonica, Phoenix Tree Seed, Hedge Prinsepia Nut are decocted twice with water, and the water being added every time is described
8 times of herbal raw material quality, each decocting time are 1h, and filtering merges filtrate twice, concentrates the filtrate at 60 DEG C
Measuring its density is 1.2g/cm3, obtains concentrated extract, and ethyl alcohol is added in concentrated extract and carries out alcohol precipitation, concentrated extract and ethyl alcohol
Weight ratio be 1:3, stand for 24 hours, take supernatant recycle ethyl alcohol, concentration, obtain Chinese herbal medicine medicinal extract i.e. Chinese herbal medicine extract 2g, store up
It hides spare；
(2) weigh auxiliary element: beta carotene, attar of rose, rose hip oil and Tween-80 after mixing, are dissolved in water, standby
With；
(3) card pool nurse is weighed, 4h is soaked in water, is sufficiently swollen, it is spare；
(4) it mixes: the product of the Chinese herbal medicine extract that step (1) is obtained and the product of step (2) addition step (3)
In, it stirs evenly, glycerol and remaining water is added, triethanolamine is added, stirs evenly；
(5) it packs: encapsulating, packaging.
Embodiment 2
1. a kind of anti-acne removes scar gel, it is made of following weight raw material:
Chinese herbal medicine extract 0.5g is made of following herbal raw material: Chinese yam 30g, 30 g of Fructus Aurantii, 3 g of ginseng, pellet
Join 20 g, 10 g of honeysuckle, 10 g of dandelion, Chinese Ladiestresses Root or Herb 2g, 2 g of Calusena lansium core, 2 g of muskmelon seed, 1.5 g of daghestan sweetclover herb, Smilacina japonica 1
G, 1 g of Phoenix Tree Seed, 1.5 g of Hedge Prinsepia Nut；
Card pool nurse 0.5g；
Water 97.00g；
Glycerol 1.0g；
Triethanolamine 0.8g；
Auxiliary element 0.2g, wherein beta carotene 0.01g, attar of rose 0.01g, rose hip oil 0.02g and Tween-80
0.16g。
Herbal raw material is weighed, obtains Chinese herbal medicine extract 0.5g by the preparation method of embodiment 1, preparation method is the same as implementation
Example 1, other methods arrive the anti-acne with embodiment 1, remove scar gel.
Embodiment 3
1. a kind of anti-acne removes scar gel, it is made of following weight raw material:
Chinese herbal medicine extract 5g is made of following herbal raw material: Chinese yam 100g, 100 g of Fructus Aurantii, 30 g of ginseng,
80 g of Radix Salviae Miltiorrhizae, 80 g of honeysuckle, 80 g of dandelion, 8 g of Chinese Ladiestresses Root or Herb, 8 g of Calusena lansium core, 8 g of muskmelon seed, 6 g of daghestan sweetclover herb, Smilacina japonica 3
G, 4 g of Phoenix Tree Seed, 3 g of Hedge Prinsepia Nut；
Card pool nurse 2g；
Water 91.1g；
Glycerol 0.3g；
Triethanolamine 1.5g；
Auxiliary element 0.1g, wherein beta carotene 0.01g, attar of rose 0.01g, rose hip oil 0.01g and Tween-80
0.07g。
Herbal raw material is weighed, obtains Chinese herbal medicine extract 5g, the same embodiment of preparation method by the preparation method of embodiment 1
1, other methods arrive the anti-acne with embodiment 1, remove scar gel.
Embodiment 4
1. a kind of anti-acne removes scar gel, it is made of following weight raw material:
Chinese herbal medicine extract 1g is made of following herbal raw material: Chinese yam 40g, 40 g of Fructus Aurantii, 3 g of ginseng, Radix Salviae Miltiorrhizae
25g, 20 g of honeysuckle, 10 g of dandelion, Chinese Ladiestresses Root or Herb 2g, 1 g of Calusena lansium core, muskmelon seed 1g, daghestan sweetclover herb 1g, Smilacina japonica 2.5g, Chinese parasol tree
Sub- 2.5g, 2.5 g of Hedge Prinsepia Nut；
Card pool nurse 0.9g；
Water 97.0g；
Glycerol 0.5g；
Triethanolamine 0.3g；
Auxiliary element 0.3g, wherein beta carotene 0.022g, attar of rose 0.022g, rose hip oil 0.022g and tween-
80 0.234g。
Herbal raw material is weighed, obtains Chinese herbal medicine extract 1g, the same embodiment of preparation method by the preparation method of embodiment 1
1, other methods arrive the anti-acne with embodiment 1, remove scar gel.
Embodiment 5
1. a kind of anti-acne removes scar gel, it is made of following weight raw material:
Chinese herbal medicine extract 3.5g is made of following herbal raw material: Chinese yam 80g, 80 g of Fructus Aurantii, 20 g of ginseng,
Radix Salviae Miltiorrhizae 60g, 75 g of honeysuckle, 50 g of dandelion, Chinese Ladiestresses Root or Herb 10g, 10 g of Calusena lansium core, muskmelon seed 10g, daghestan sweetclover herb 7g, Smilacina japonica 5
G, Phoenix Tree Seed 6g, 5 g of Hedge Prinsepia Nut；
Card pool nurse 2.0g；
Water 91.76g；
Glycerol 1.0g；
Triethanolamine 1.5g；
Auxiliary element 0.24g, wherein beta carotene 0.01g, attar of rose 0.02g, rose hip oil 0.01g and Tween-80
0.2g。
Herbal raw material is weighed, obtains Chinese herbal medicine extract 3.5g by the preparation method of embodiment 1, preparation method is the same as implementation
Example 1, other methods arrive the anti-acne with embodiment 1, remove scar gel.
Comparative example 1
Using the preparation method of the embodiment of the present invention 1, wherein traditional Chinese medicine ingredients are Chinese yam 45g, 43 g of Fructus Aurantii, 4 g of ginseng, pellet
Join 30 g, 37 g of honeysuckle, 12 g of dandelion, other components are identical with embodiment 1, are prepared into a kind of gel.
Embodiment 6
Inhibition test to propionibacterium acnes
Whelk is also acne, mainly with hypersteatosis, pilosebaceous duct blocking, bacterium infection and inflammation
The factors such as reaction are closely related.After adolescing, human body internal hormone content changes, and sebaceous glands is promoted to develop and generate
A large amount of sebums.The cutin of pilosebaceous duct causes catheter blockage extremely simultaneously, dyssebacia, forms horn plug and micro-
Acne.Multiple-microorganism especially propionibacterium acnes mass propagation in hair follicle, the lipase that propionibacterium acnes generate decompose skin
Rouge generates free fatty acid, has aggravated degree of inflammation.It can be seen that the mass propagation of propionibacterium acnes is to induce whelk simultaneously
A major reason for causing whelk to deteriorate, therefore, one of evaluation effect of product for resolving poxes is exactly to inhibit propionibacterium acnes
Ability.
1. test specimen
The obtained anti-acne of embodiment 1-5 removes scar gel, and the gel of comparative example 1, propionibacterium acnes bacterial strain are (by acne
Patient skin breakage obtains).
2. test method
Culture, separation, the identification of anaerobic bacteria: it culture: isolated sample will be inoculated at patients with acne skin injury
In TH10 culture medium, with airbag method, 37 DEG C of culture 72h in anaerobic jar is placed in, indicator are made with methylene blue, palladium grain makees catalyst.Point
From: picking single bacterium colony turns 2 pieces of plates, and one piece is placed in anaerobic jar, and lower 37 DEG C of anaerobic condition；Another piece with 37 DEG C of aerobic trainings
It supports；Result is observed after 48h.Identification: without bacterial growth under aerobic culture；Occur on the plate of Anaerobic culturel form, it is greyish white
The slightly neat bacterium colony in color, the circle of tiny, diameter about 1.0mm protrusion, edge, makees microscopy, visible chromabacterium biolaceum under mirror for bacterium colony.It is micro-
It is curved in rodlike or rod-shaped, can one end blunt circle, one end attenuates, and coloring is not deep, cell be it is single, can arrange or arrange in pairs is " people "
Shape.It is again propionibacterium acnes through oxytolerant test, catalyst test, indole test, biochemical serial test for identification.
Anaerobism drug sensitive test:
Strain inoculated: 1 colony inoculation in the bacterium colony more than picking cultivated is on LB plating medium, 37 DEG C of aerobic trainings
It supports for 24 hours, by aerobic culture, propionibacterium acnes are rinsed with sterile saline for 24 hours, and flushing liquor is put into sterile test tube；Using wheat
Family name's turbidimetry is than turbid, and opacity tube is with shaking 12 times is before needed, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL
It is spare.
The inoculation of LB plating medium: dipping bacterium solution for the swab stick of sterilizing, goes extra bacterium solution in squeezing on tube wall, trains in LB plate
It supports and is uniformly smeared on base, and sweep a circle along plate edge ring, cover plate, dry 2min.Diameter is light for the sterile steel bowl of 6mm
It is put on plating medium, fills it up with test specimen, be put into 37 DEG C of aerobic cultures for 24 hours, without bacterial growth in discovery plate, continue 37
DEG C aerobic culture has inhibition zone generation afterwards for 24 hours.Antibacterial circle diameter is measured, the antibacterial circle diameter of each test specimen takes 3 groups of measurements
Average value.
3. test result
The anti-acne of embodiment 1-5 preparation removes scar gel as experimental group, and the gel provided using comparative example 1 is control group, medium-height grass
Medicine antibacterial susceptibility grade classification, referring to corresponding antibiotic standard, antibacterial circle diameter > 20mm is Gao Min, 10-20mm be in quick, <
10mm is drug resistance, and concrete outcome is shown in Table 1.
The inhibitory effect of 1 propionibacterium acnes of table
Table 1 the results show that a kind of anti-acne provided by the invention, except scar gel and control group have inhibiting acne propionic acid
The effect of bacillus, and anti-acne provided by the invention, there is high quick effect (antibacterial circle diameter > to propionibacterium acnes except scar gel
20mm), and using Chinese yam, Fructus Aurantii, ginseng, Radix Salviae Miltiorrhizae, honeysuckle, dandelion as the acne-removing composition of Chinese medicine material have in quick work
With, it can thus be seen that anti-acne provided by the invention, except in the herbal raw material of scar gel, Chinese yam, Fructus Aurantii, ginseng, Radix Salviae Miltiorrhizae,
Honeysuckle, dandelion are combined with Chinese Ladiestresses Root or Herb, Calusena lansium core, muskmelon seed, daghestan sweetclover herb, Smilacina japonica, Phoenix Tree Seed, Hedge Prinsepia Nut with synergy
Effect.
Embodiment 7
The antiallergy of Chinese medicinal herbs raw material of the present invention is tested.
1. experimental animal
SD rat, all-male, quality (200 ± 20) g, SPF grade.
2. trial drug
It weighs in embodiment 1, Chinese yam 45g, 43 g of Fructus Aurantii, 4 g of ginseng, 30 g of Radix Salviae Miltiorrhizae, 37 g of honeysuckle, dandelion 12
G, Chinese Ladiestresses Root or Herb 3g, 3 g of Calusena lansium core, 2 g of muskmelon seed, 2 g of daghestan sweetclover herb, 2 g of Smilacina japonica, 2 g of Phoenix Tree Seed, 2 g of Hedge Prinsepia Nut decoct two with water
Secondary, the water being added every time is 8 times of the herbal raw material quality, and each decocting time is 1h, and filtering merges filter twice
Liquid, concentrate the filtrate to measured at 60 DEG C its density be 1.2g/cm3, obtain concentrated extract, concentrated extract be added ethyl alcohol into
The weight ratio of row alcohol precipitation, concentrated extract and ethyl alcohol is 1:3, is stood for 24 hours, and supernatant is taken to recycle ethyl alcohol, and concentration obtains Chinese herbal medicine leaching
Cream, that is, Chinese herbal medicine extract takes 0.5g that 100mL distilled water is added and is diluted to test group.
Chinese medicinal material extract in comparative example 1 is gel controls group, weighs Chinese yam 45g, 43 g of Fructus Aurantii, 4 g of ginseng, Radix Salviae Miltiorrhizae
30 g, 37 g of honeysuckle, 12 g of dandelion, the same test group of extracting method take its extract 0.5g that the dilution of 100mL distilled water is added
At gel controls group.
Chlorpheniramine, the production of Tai Ji southwest pharmaceutcal corporation, Ltd；Ovalbumin, the production of Sigma company；DPT vaccine, it is military
The production of Chinese institute of biological products；Toluidine blue dye liquor, such as lucky Biotechnology Co., Ltd's import packing.
3. test method
Antiserum prepares: taking male SD rat 10, injects 1% egg albumin solution in every two leg muscle of rat
0.5mL, the next day sensitization it is primary, altogether three times.Rat aorta takes blood after last sensitization 13d, centrifugation, 3500r/min,
10min separates serum and saves, saves backup in -20 DEG C of refrigerators.Antiserum physiological saline 1:1 and 1:2 dilute spare.It takes
Rat 50,5 groups are randomly divided into, every group 10, i.e. blank control group, model control group, chlorpheniramine group (5mg/kg), the present invention
Chinese medicinal herbs extract test group (7.0g/kg), gel controls group (7.0g/kg), gastric infusion, 1 time/mention day, continuous 6d.It gives
Medicine the 4th day, lost hair or feathers 3cm × 3cm for each rat back left and right sides, and next day injects antiserum 0.1mL sensitization, blank at depilation
Sensitization, the left and right sides are not respectively 1:1 and 1:2 antiserum to group.After rat injects antiserum 48h, the injection of each group rat tail vein
0.5% Evans Blue solution of user is made into the egg albumin solution 1mL/100g attack of 2mg/mL.Sacrificed by decapitation rat after 30min,
Skin of back is inverted, the locus coeruleus skin of 1:1 and 1:2 is removed with 1.2cm punch, is shredded, is respectively charged into oiling 5mL acetone: is raw
It is impregnated in reason salt water=7:3 mixed liquor, 37 DEG C of overnight incubations, centrifugation, 3500r/min, 10min, takes supernatant, surveyed at 590nm
Determine absorbance value.Inhibiting rate according to the following formula:
Inhibiting rate=[(model group absorbance value-administration group absorbance value) ÷ model group absorbance value] × 100%.
4. experimental result
It the results are shown in Table 2.
2 each group allotransplantation in rats passive cutaneous anaphylaxis of table influence ()
Wherein, the * P < 0.05 compared with model group.
Compared with blank group, the absorbance value of model group is significantly raised, compared with model group, chlorpheniramine group, test group and
The absorbance value of control group is substantially reduced, and the anti-allergic effects of Chinese medicinal herbs extract of the present invention are suitable in commercially available chlorpheniramine,
And the Chinese medicinal material extract of control group also has anti-allergic effects, but effect is significantly lower than test group, illustrates Chinese yam, Fructus Aurantii, people
Ginseng, Radix Salviae Miltiorrhizae, honeysuckle, dandelion combine with Chinese Ladiestresses Root or Herb, Calusena lansium core, muskmelon seed, daghestan sweetclover herb, Smilacina japonica, Phoenix Tree Seed, Hedge Prinsepia Nut has association
With the effect of enhancing anti-allergic effects.
Embodiment 8
Anti-acne effect clinical test.
Trier: randomly selecting whelk patient 600 of 15-30 years old, and average age is 20 years old, and men and women is fifty-fifty.It is flat
6 groups are divided into, respectively 5 groups of test groups and 1 group of control group, every group of men and women are fifty-fifty.
Test specimen: anti-acne that test group 1-5 uses 1-5 of the embodiment of the present invention to provide respectively removes scar gel, and control group makes
The gel prepared with comparative example 1.7 days as a course for the treatment of.The metabolic period of skin is 28 days, and the present invention 7 days are 1 treatment
Journey takes 4 course for the treatment of altogether.
After morning and evening face cleaning, takes test specimen appropriate, be applied to affected part.Use 4 courses for the treatment of.Respectively after using 2 years and 4 years
It pays a return visit.
Disease classification:
Classification of severity helps correctly to select therapeutic scheme, is classified according to standard general at present:
Slightly (1 grade): based on acne, a small amount of papule useless fellow, total skin lesion < 30；
Moderate (2 grades): acne, the papule useless fellow of moderate quatity, total skin lesion are 30-50；
Severe (3 grades): a large amount of papule useless fellow has inflammation skin lesion once in a while, widely distributed, and total skin lesion is 51-100, knot
< 3, section；
Severe (4 grades): nodositas, Cystic small pox with pain and form tumour, extra 100 of total skin lesion, tubercle
Tumour is crossed more than 3.
The trier that this test is chosen is severe (4 grades).
The standard of curative effect evaluation:
Recovery from illness: small pox, acne print disappear, and skin smooth finish is discontinued after half a year without recurrence；
Effective: total skin lesion number reduces 60% or more；
Invalid: no significant change or total skin lesion number reduce 40% or more.
Treatment results are shown in Table 3.
3 anti-acne treatment results of table
It can be seen from the results above that 1-5 of the embodiment of the present invention preparation anti-acne, except scar gel due to composition have compared with
Good synergistic function, cure rate is higher, total effective rate 100%, especially for the whelk patient of severe.In medication 2
After it, small pox redness phenomenon obviously subsides, and starts to peel, and after two weeks, that is, brings about tangible results, total effective rate
Up to 65% or more, the acne print of the patient facial region of healing also all disappears, skin smooth finish.To trier after 2 years and after 4 years
It is paid a return visit respectively, no case was recurrence.Anti-acne prepared by the present invention removes scar gel, easy to use, is applied to affected part, no
It will affect beauty, there is preferable therapeutic effect for the whelk patient of severe, do not recur.
Embodiment 9
Except scar effect assessment.
In order to verify it is of the invention except scar effect, randomly selecting 300 and not existing together in skin has the patient of scar, every trouble
The scar area of person is both less than 100cm2, 6 groups are randomly divided into, every group of 50 people, 5 groups of test groups and 1 group of control group, test group use
The anti-acne of 1-5 of embodiment of the present invention preparation removes scar gel, smears sooner or later daily each primary behind cleaning affected part, and control group uses city
The Aloe Vera Gel sold.7 days as a course for the treatment of, and use 6 course for the treatment of criterion: scar disappears: scar disappears, and calm pigment disappears；
Effective: scar reduces 70% or more, and calm pigment mitigates；Invalid: scar reduces 30% or less.Test result is shown in Table 4.
4 scar repairing effect of table
As shown in Table 4, anti-acne prepared by the present invention, except scar gel to skin scar have preferable repairing effect.
Claims (5)
1. a kind of anti-acne removes scar gel, it is made of Chinese herbal medicine extract, carbomer, water, glycerol, triethanolamine and auxiliary element,
The weight percent of each component is as follows: Chinese herbal medicine extract 0.5-5%, carbomer 0.5-2%, water 90-97%, glycerol 0.3-1%,
Triethanolamine 0.3-1.5%, auxiliary element 0.1-0.3%, it is characterised in that: the Chinese herbal medicine extract is by following parts by weight
Herbal raw material is made: 30-100 parts of Chinese yam, 30-100 parts of Fructus Aurantii, 3-30 parts of ginseng, 20-80 parts of Radix Salviae Miltiorrhizae, 10-80 parts of honeysuckle,
10-80 parts of dandelion, 2-10 parts of Chinese Ladiestresses Root or Herb, 1-10 parts of Calusena lansium core, 1-10 parts of muskmelon seed, 1-7 parts of daghestan sweetclover herb, 1-5 parts of Smilacina japonica, Chinese parasol tree
1-6 parts of the seeds of a tung oil tree, 1-5 parts of Hedge Prinsepia Nut.
2. anti-acne according to claim 1 removes scar gel, it is characterised in that: the Chinese herbal medicine extract is by following weight
The raw material of part is made: 40-80 parts of Chinese yam, 40-80 parts of Fructus Aurantii, 3-20 parts of ginseng, 25-60 parts of Radix Salviae Miltiorrhizae, 20-75 parts of honeysuckle, Pu
Public English 10-50 parts, 2-8 parts of Chinese Ladiestresses Root or Herb, 2-8 parts of Calusena lansium core, 2-8 parts of muskmelon seed, 1.5-6 parts of daghestan sweetclover herb, 1-3 parts of Smilacina japonica, Chinese parasol tree
It is 2-4 parts sub-, 1-3 parts of Hedge Prinsepia Nut.
3. anti-acne according to claim 2 removes scar gel, it is characterised in that: the Chinese herbal medicine extract is by following weight
The raw material of part is made: 45 parts of Chinese yam, 43 parts of Fructus Aurantii, 4 parts of ginseng, 30 parts of Radix Salviae Miltiorrhizae, 37 parts of honeysuckle, 12 parts of dandelion, Chinese Ladiestresses Root or Herb 3
Part, 3 parts of Calusena lansium core, 2 parts of muskmelon seed, 2 parts of daghestan sweetclover herb, 2 parts of Smilacina japonica, 2 parts of Phoenix Tree Seed, 2 parts of Hedge Prinsepia Nut.
4. anti-acne according to claim 1, remove scar gel, it is characterised in that: the auxiliary element by beta carotene,
Attar of rose, rose hip oil and Tween-80 form, wherein the weight ratio of beta carotene, attar of rose, rose hip oil and Tween-80
Are as follows: (1-2): (1-2): (1-2): (7-20).
5. a kind of anti-acne described in claim 1, except the preparation method of scar gel, it is characterised in that: the following steps are included:
(1) prepare Chinese herbal medicine extract: weigh Chinese yam, Fructus Aurantii, ginseng, Radix Salviae Miltiorrhizae, honeysuckle, dandelion, Chinese Ladiestresses Root or Herb, Calusena lansium core,
Muskmelon seed, daghestan sweetclover herb, Smilacina japonica, Phoenix Tree Seed, Hedge Prinsepia Nut are decocted twice with water, and the water being added every time is the herbal raw material quality
8 times, each decocting time is 1h, and filtering merges filtrate twice, concentrates the filtrate to and measures its density at 60 DEG C and be
1.2g/cm3, concentrated extract is obtained, ethyl alcohol is added in concentrated extract and carries out alcohol precipitation, the weight ratio of concentrated extract and ethyl alcohol is 1:
3, it stands for 24 hours, supernatant is taken to recycle ethyl alcohol, concentration obtains Chinese herbal medicine medicinal extract, as Chinese herbal medicine extract, is in store for；
(2) auxiliary element is weighed, after auxiliary element is mixed, is dissolved in water, it is spare；
(3) carbomer is weighed, 4h is soaked in water, is sufficiently swollen, it is spare；
(4) mix: the Chinese herbal medicine extract that step (1) is obtained and the product of step (2) are added in the product of step (3), stir
It mixes uniformly, glycerol and remaining water is added, triethanolamine is added, stirs evenly；
(5) it packs: encapsulating, packaging.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895593A (en) * | 2006-06-23 | 2007-01-17 | 段阳泉 | Medicine for treating acne and its preparation |
| CN103405746A (en) * | 2013-07-29 | 2013-11-27 | 朱耀灯 | Gel capable of fast removing acne |
| CN104434740A (en) * | 2014-12-16 | 2015-03-25 | 皖南医学院 | Traditional Chinese medicine gel for removing acnes and preparation method of traditional Chinese medicine gel |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003081844A (en) * | 2001-09-11 | 2003-03-19 | Kao Corp | Emollient of skin irritation |
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895593A (en) * | 2006-06-23 | 2007-01-17 | 段阳泉 | Medicine for treating acne and its preparation |
| CN103405746A (en) * | 2013-07-29 | 2013-11-27 | 朱耀灯 | Gel capable of fast removing acne |
| CN104434740A (en) * | 2014-12-16 | 2015-03-25 | 皖南医学院 | Traditional Chinese medicine gel for removing acnes and preparation method of traditional Chinese medicine gel |
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Denomination of invention: Gel for removing acne and removing scar and preparation method thereof Effective date of registration: 20201203 Granted publication date: 20190108 Pledgee: Shaanxi cultural industry finance Company limited by guarantee Pledgor: SHAANXI RENKANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2020610000223 |
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Denomination of invention: A kind of acne and scar removing gel and its preparation method Effective date of registration: 20230213 Granted publication date: 20190108 Pledgee: Shaanxi cultural industry finance Company limited by guarantee Pledgor: SHAANXI RENKANG PHARMACEUTICAL CO.,LTD. Registration number: Y2023610000095 |
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