CN108686023A - A kind of antipruritic moisturizing essential oil for treating geroderma itch - Google Patents
A kind of antipruritic moisturizing essential oil for treating geroderma itch Download PDFInfo
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Abstract
The purpose of the present invention is just to provide a kind of antipruritic moisturizing essential oil for treating geroderma itch, is made of following drug mixing:Japan pepper essential oil 2-4ml, P-Cymene 2-4ml, Radix Glycyrrhizae essential oil 2-4ml, fruit of summer cypress essential oil 1.5-2.5ml, kuh-seng essential oil 1.5-2.5ml, root of Dahurain angelica essential oil 1.5-2.5ml, Snakegourd Fruit essential oil 1.5-2.5ml, Fructus Perillae quintessence oil 1.5-2.5ml, Peppermint essential oil 1.5-2.5ml and borneol 2-3g;Prescription of the present invention is scientific and reasonable, abundant raw material, preparation easy to produce, has disinfectant antipruritic, the effect of moistening skin, effective for treating geroderma itch, good effect, drug safety is the innovation treated on geroderma itch drug, there is good economic and social benefit.
Description
Technical field
The present invention relates to Chinese medicine, especially a kind of antipruritic moisturizing essential oil for treating geroderma itch.
Background technology
Geroderma itch is clinical common disease, especially in drying, cold the Northwest, the incidence of the disease
It is very high.Pruitus belong to " pruritus " of traditional Chinese medicine, " pruritus due to wind pathogen " scope.Cutaneous pruritus is that one kind with itch is main
Symptom does not occur the disease of primary cutaneous damage, and patient is difficult to be resistant to, and may occur in which secondary scratch, pigment after scratching repeatedly
The clinical symptoms such as calmness, scab.The disease is difficult to thoroughly cure, and easy recurrent exerbation influences patients ' life quality.Though chemical drug treatment has
Certain curative effect has an impact mostly with the adverse reactions such as drowsiness, weak to working, living, though existing have treatment geroderma scabies
The a variety of drugs itched, for various reasons, therapeutic effect are simultaneously unsatisfactory, and therefore, improvement and innovation gesture on drug exist
It must go.
Invention content
For the above situation, to overcome the defect of the prior art, the purpose of the present invention be just to provide it is a kind of treat it is senile
The antipruritic moisturizing essential oil of pruitus can effectively solve the problems, such as the medication for the treatment of geroderma itch.
The technical solution that the present invention solves is that a kind of antipruritic moisturizing essential oil for treating geroderma itch, is by following
Drug mixing is made:Japan pepper essential oil 2-4ml, P-Cymene 2-4ml, Radix Glycyrrhizae essential oil 2-4ml, fruit of summer cypress essential oil 1.5-2.5ml are bitter
Join essential oil 1.5-2.5ml, root of Dahurain angelica essential oil 1.5-2.5ml, Snakegourd Fruit essential oil 1.5-2.5ml, Fructus Perillae quintessence oil 1.5-2.5ml, peppermint essence
Oily 1.5-2.5ml and borneol 2-3g;
The Japan pepper essential oil is that Chinese prickly ash was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain pepper essence
Oil;
The P-Cymene is that folium artemisiae argyi was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain folium artemisiae argyi essence
Oil;
The Radix Glycyrrhizae essential oil is that Radix Glycyrrhizae was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain licorice
Oil;
The fruit of summer cypress essential oil is that the fruit of summer cypress was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extracts
It takes, feed liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, extraction temperature 42~50
DEG C, 20~25MPa of extracting pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature,
Obtain fruit of summer cypress essential oil;
The kuh-seng essential oil is that kuh-seng was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain kuh-seng essence
Oil;
The root of Dahurain angelica essential oil is that the root of Dahurain angelica was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain root of Dahurain angelica essence
Oil;
The Snakegourd Fruit essential oil is that Snakegourd Fruit was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain Snakegourd Fruit essence
Oil;
The Fructus Perillae quintessence oil is that purple perilla was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain purple perilla essence
Oil;
The Peppermint essential oil is that peppermint was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material
Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction
20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain peppermint essence
Oil.
Prescription of the present invention is scientific and reasonable, abundant raw material, preparation easy to produce, has the effect of disinfectant antipruritic, moistening skin, has
Effectiveness is the innovation treated on geroderma itch drug, has in treatment geroderma itch, good effect, drug safety
Good economic and social benefit.
Specific implementation mode
It elaborates to the specific implementation mode of the present invention below in conjunction with concrete condition and embodiment.
The specific embodiment of the invention can be provided by following embodiment.
Embodiment 1:A kind of antipruritic moisturizing essential oil for treating geroderma itch of the present invention, is by following drug mixing system
At:Japan pepper essential oil 3ml, P-Cymene 3ml, Radix Glycyrrhizae essential oil 3ml, fruit of summer cypress essential oil 2ml, kuh-seng essential oil 2ml, root of Dahurain angelica essential oil 2ml,
Snakegourd Fruit essential oil 2ml, Fructus Perillae quintessence oil 2ml, Peppermint essential oil 2ml and borneol 3g.
Embodiment 2:A kind of antipruritic moisturizing essential oil for treating geroderma itch of the present invention, is by following drug mixing system
At:Japan pepper essential oil 2ml, P-Cymene 2ml, Radix Glycyrrhizae essential oil 2ml, fruit of summer cypress essential oil 1.5ml, kuh-seng essential oil 1.5ml, root of Dahurain angelica essential oil
1.5ml, Snakegourd Fruit essential oil 1.5ml, Fructus Perillae quintessence oil 1.5ml, Peppermint essential oil 1.5ml and borneol 2g.
Embodiment 3:A kind of antipruritic moisturizing essential oil for treating geroderma itch of the present invention, is by following drug mixing system
At:Japan pepper essential oil 4ml, P-Cymene 4ml, Radix Glycyrrhizae essential oil 4ml, fruit of summer cypress essential oil 2.5ml, kuh-seng essential oil 2.5ml, root of Dahurain angelica essential oil
2.5ml, Snakegourd Fruit essential oil 2.5ml, Fructus Perillae quintessence oil 2.5ml, Peppermint essential oil 2.5ml and borneol 3g.
Embodiment 4:A kind of antipruritic moisturizing essential oil for treating geroderma itch of the present invention, is by following drug mixing system
At:Japan pepper essential oil 2ml, P-Cymene 4ml, Radix Glycyrrhizae essential oil 2ml, fruit of summer cypress essential oil 2.5ml, kuh-seng essential oil 1.5ml, root of Dahurain angelica essential oil
2.5ml, Snakegourd Fruit essential oil 1.5ml, Fructus Perillae quintessence oil 2.5ml, Peppermint essential oil 1.5ml and borneol 3g.
Embodiment 5:A kind of antipruritic moisturizing essential oil for treating geroderma itch of the present invention, is by following drug mixing system
At:Japan pepper essential oil 4ml, P-Cymene 2ml, Radix Glycyrrhizae essential oil 4ml, fruit of summer cypress essential oil 1.5ml, kuh-seng essential oil 2.5ml, root of Dahurain angelica essential oil
1.5ml, Snakegourd Fruit essential oil 2.5ml, Fructus Perillae quintessence oil 1.5ml, Peppermint essential oil 2.5ml and borneol 2g.
The present invention achieves extraordinary effect through experiment and on the spot application:Related testing data is as follows:
One, animal experiment:
1 experiment material
1.1 laboratory apparatus:
FA (N)/JA (N) a series of electronic balances, Shanghai Min Qiao precision instruments Co., Ltd;
1.2 experiment reagent:
The antipruritic moisturizing essential oil of the present invention.Skin must pacify, the limited public production of Shenyang Kang Shi Medicines and Health Products.Depilatory cream, Shanghai poem
Green cosmetics Co., Ltd production.Sodium chloride injection, Shangdong Hualu Pharmaceutical Co., Ltd.'s production.Dextran, Beijing Suo Lai
Precious Science and Technology Ltd.'s production.
1.3 experimental animal
20-22g KM mouse, half male and half female, SPF grades, certification of fitness No.37009200007439, Shandong Province's experiment is dynamic
The object center Shandongs credit number SCXK 20140007.Experimental unit uses licensing number SYXK (Henan) 2015-0005.
2 experimental methods
2.1 animal feeding
22-26 DEG C of temperature, humidity 40-60%, artificial light replaced with 12 hour night, give conventional 12 hour daytimes
Laboratory diet, not water restriction.
2.2 experimental method
Take KM mouse 48, half male and half female is randomly divided into 4 groups, every group 12, i.e. model group, skin must pacify group, large and small dose
Measure antipruritic moisturizing essential oil group.The hair that the preceding 1d of administration sloughs mouse part skin is spare, and then dermal application is administered at unhairing, model
Group applies 0.9% sodium chloride injection (0.3ml is applied at twice, each 0.15ml), the large and small antipruritic moisturizing essential oil group of dosage (former essence
Oil dilutes one times of essential oil with atoleine, is 0.3ml, applies at twice, each 0.15ml), skin, which must pacify a group painting skin, must pacify ointment
0.3g (thickness 2mm).30min (each group is first to apply once, and 15min is applied once again).Then each group mouse tail vein injection
0.025% Dextran 5 mLkg-1 (1.25mgkg-1) is to get mouse itch model.It is scratched one's head portion, rear solid end with mouse fore paw
Scratch trunk, mouth stings each position of whole body as itch indication.
Record itch incubation period (injection terminates the time started to the 1st scratching), tickle for the 1st time after mouse in 30min
Itch number.Injection site to stopping persistently being scratched with mouse hind leg is denoted as 1 scratching (continuously broadcast to grab and be denoted as 1 time).Itch time
Number:From the 1st action that tickles of itch model mice, the total degree that tickles in 30min is recorded.
2.3 statistical method
Experimental data with SPSS21 statistical softwares handle, data withIt indicates, comparison among groups are examined using t.
3 experimental results
Influence of the 1 Chinese medicine itching-stopping prescription of table to mouse itch model
Note:**P<0.01, * P<0.05, it indicates compared with model group
It can be seen that from upper table, compared with model group, the antipruritic moisturizing essential oil group of large and small dosage and skin must pacify group and can significantly prolong
Long mouse itch time (P< for the first time;0.01) mouse itch number (P<, is substantially reduced;0.01).
Two, to the influence of guinea pig skin itch model
1 experiment material
1.1 laboratory apparatus:
FA (N)/JA (N) a series of electronic balances, Shanghai Min Qiao precision instruments Co., Ltd;
1.2 experiment reagent:
Essential oil of the present invention.Skin must pacify, the production of Shenyang Kang Shi Medicines and Health Products Co., Ltd.Depilatory cream, the green makeup of Shanghai poem
Product Co., Ltd produces.Sodium chloride injection, Shangdong Hualu Pharmaceutical Co., Ltd.'s production.Histamine phosphate, Yuan Ye biotinylated biomolecules section
Skill Co., Ltd produces.
1.3 experimental animal
Cavy, 250~280g of weight, half male and half female, regular grade, Shandong Province's Experimental Animal Center certification of fitness:
NO.37009200000334, credit number:The Shandongs SCXK 20140007.Experimental unit is numbered using licensing:SYXK (Henan)
2015-0005。
2 experimental methods
2.1 animal feeding:
22-26 DEG C of temperature, humidity 40-60%, artificial light replaced with 12 hour night, give conventional 12 hour daytimes
Laboratory diet, not water restriction.
2.2 experimental method
Take healthy guinea pig 48, half male and half female, 250~280g.It is randomly divided into 4 groups, every group 12, respectively:Model group,
Skin must pacify group, the large and small antipruritic moisturizing essential oil group of dosage.After the right metapedes depilation for 24 hours of animal, instep is lost hair or feathers behind each cavy right side respectively
Regional administration, big low dose of antipruritic moisturizing essential oil group (former essential oil dilutes one times of essential oil with atoleine, is 0.15ml), skin
Ointment 0.3g (thickness 2mm) must be pacified by obtaining the deposited skin of peace group, and model group applies 0.9% sodium chloride injection 0.3mL.Keep 15min.
After 15min with gauze friction part to have oozing of blood point (with oozing of blood, without apparent bleeding be degree), area 1cm2, then give with method same amount
Corresponding medicine 1 time, and in 10min after administration, smear 0.01% histamine phosphate, 50 μ L at the surface of a wound respectively, later every
In same area, drop increasing concen-trations are 0.02%, 0.03%, 0.04% ... equivalent histamine phosphate to 3min successively again, until going out
Until existing cavy later licks foot, using the total amount for the histamine phosphate dripped to each animal in this time as itch-threshold, such as drop to
0.1% histamine phosphate cavy does not lick metapedes yet, then total amount is added dropwise as itch-threshold, compares the itch-threshold of each group.
2.3 statistical method
Experimental data with SPSS21 statistical softwares handle, data withIt indicates, comparison among groups are examined using t.
3 experimental results
Influence of the 2 Chinese medicine itching-stopping prescription of table to cavy itch model
Note:**P<0.01, it indicates compared with model group
It can be seen that from upper table, compared with model group, the antipruritic moisturizing essential oil group of large and small dosage and skin must pacify group and can obviously rise
The cause of high cavy is itched domain (P<0.01).
Two, clinical test:
On the basis of ensuring animal experiment safety, clinically through trying out, very satisfied Advantageous is also achieved
Effect, relevant information are as follows:
1, the standard of case is selected:
Geroderma itch is clinical common disease, especially in drying, cold the Northwest, the incidence of the disease
It is very high.Pruitus belong to " pruritus " of traditional Chinese medicine, " pruritus due to wind pathogen " scope.Cutaneous pruritus is that one kind with itch is main
Symptom does not occur the disease of primary cutaneous damage, and patient is difficult to be resistant to, and may occur in which secondary scratch, pigment after scratching repeatedly
The clinical symptoms such as calmness, scab.It is all that there is above-mentioned symptom person, the alternatively standard of case.
2, diagnostic criteria:
It is all that there is above-mentioned symptom, it chemically examines after diagnosing, you can be diagnosed as with geroderma itch, and give medicine of the present invention
Object is treated.
3, therapeutic scheme:
Drug therapy of the present invention is used to the patient that makes a definite diagnosis, twice daily, once in the morning and once at night, is applied to affected part, continuous two weeks
As a treatment course, and set control group while experiment, control group takes orally cetirizine, 10mg/ times, once a day, two groups of treatments
Period rationally adjusts diet, reduces bathing number, disables alkaline soap, loose cotton clothes.
4, efficacy assessment standard:
The scoring of curative effect degree assesses two groups of patient's itch degree using visual analogue scales (VAS), and (1~3) is divided into slightly,
(4~6) are divided into moderate, and (7~10 points are severe.
Efficacy determination carries out rank scores to patient's itch degree, occurrence frequency, duration, itch area etc., and 0 point is
Nothing, 5 points are light, and during 10 points are, 15 points are weight, count every score summation before and after treatment.Therapeutic index=(the preceding total score-for the treatment of
Total score after treatment) preceding total score × 100% of/treatment.Therapeutic index >=95% is recovery from illness;70%≤therapeutic index < 95% is aobvious
Effect;30%≤therapeutic index < 70% is effective;Therapeutic index < 30% is invalid.Total effective rate=(recovery from illness is+effective+to be had
Effect)/total number of cases × 100%.
5, statistical procedures:
Through 56 patients to making a definite diagnosis, it is randomly divided into of the present invention group and control group, each 28, wherein itch degree:This hair
Bright 28, VAS scorings 7.8 ± 1.6 before treating, 2.1 ± 0.9 after treatment;Control group 28, treat before VAS scoring 7.7 ±
1.5,3.9 ± 1.2 after treatment.
It of the present invention group 28, fully recovers 9 (32.1%), it is effective 13 (46.4%), it is effective 4 (14.3%), invalid 2
Example (7.1%), total effective rate 92.9%.Control group 28 is fully recovered 2 (7.1%), effective 10 (35.7%), effective 8
(28.6%), invalid 8 (28.6%), total effective rate 71.4%.And during experiment, any adverse reaction and poison are not found
Side effect.
6, conclusion:From the above, it is seen that prescription of the present invention is scientific and reasonable, abundant raw material, preparation easy to produce has disinfection
Antipruritic, the effect of moistening skin, effective for treating geroderma itch, good effect, curative effect is up to 92% or more, and curative effect is steady
Fixed reliable, drug safety is the innovation treated on geroderma itch drug, there is good economic and social benefit.
Claims (6)
1. a kind of antipruritic moisturizing essential oil for treating geroderma itch, it is characterized in that:It is made of following drug mixing:Chinese prickly ash
Essential oil 2-4ml, P-Cymene 2-4ml, Radix Glycyrrhizae essential oil 2-4ml, fruit of summer cypress essential oil 1.5-2.5ml, kuh-seng essential oil 1.5-2.5ml,
Root of Dahurain angelica essential oil 1.5-2.5ml, Snakegourd Fruit essential oil 1.5-2.5ml, Fructus Perillae quintessence oil 1.5-2.5ml, Peppermint essential oil 1.5-2.5ml and borneol
2-3g;
The Japan pepper essential oil is that Chinese prickly ash was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, feed liquid weight
Volume ratio 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extracting pressure 20
~25MPa, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain Japan pepper essential oil;
It is the P-Cymene, Radix Glycyrrhizae essential oil, fruit of summer cypress essential oil, kuh-seng essential oil, root of Dahurain angelica essential oil, Snakegourd Fruit essential oil, Fructus Perillae quintessence oil, thin
The same Japan pepper essential oil of lotus essential oil preparation method.
2. the antipruritic moisturizing essential oil for the treatment of geroderma itch according to claim 1, it is characterized in that:It is by with prescribe medicine
Object mixing is made:Japan pepper essential oil 3ml, P-Cymene 3ml, Radix Glycyrrhizae essential oil 3ml, fruit of summer cypress essential oil 2ml, kuh-seng essential oil 2ml, the root of Dahurain angelica
Essential oil 2ml, Snakegourd Fruit essential oil 2ml, Fructus Perillae quintessence oil 2ml, Peppermint essential oil 2ml and borneol 3g.
3. the antipruritic moisturizing essential oil for the treatment of geroderma itch according to claim 1, it is characterized in that:It is by following
Drug
Mixing is made:Japan pepper essential oil 2ml, P-Cymene 2ml, Radix Glycyrrhizae essential oil 2ml, fruit of summer cypress essential oil 1.5ml, kuh-seng essential oil
1.5ml, root of Dahurain angelica essential oil 1.5ml, Snakegourd Fruit essential oil 1.5ml, Fructus Perillae quintessence oil 1.5ml, Peppermint essential oil 1.5ml and borneol 2g.
4. the antipruritic moisturizing essential oil for the treatment of geroderma itch according to claim 1, it is characterized in that:It is by with prescribe medicine
Object
Mixing is made:Japan pepper essential oil 4ml, P-Cymene 4ml, Radix Glycyrrhizae essential oil 4ml, fruit of summer cypress essential oil 2.5ml, kuh-seng essential oil
2.5ml, root of Dahurain angelica essential oil 2.5ml, Snakegourd Fruit essential oil 2.5ml, Fructus Perillae quintessence oil 2.5ml, Peppermint essential oil 2.5ml and borneol 3g.
5. the antipruritic moisturizing essential oil for the treatment of geroderma itch according to claim 1, it is characterized in that:It is by with prescribe medicine
Object
Mixing is made:Japan pepper essential oil 2ml, P-Cymene 4ml, Radix Glycyrrhizae essential oil 2ml, fruit of summer cypress essential oil 2.5ml, kuh-seng essential oil
1.5ml, root of Dahurain angelica essential oil 2.5ml, Snakegourd Fruit essential oil 1.5ml, Fructus Perillae quintessence oil 2.5ml, Peppermint essential oil 1.5ml and borneol 3g.
6. the antipruritic moisturizing essential oil for the treatment of geroderma itch according to claim 1, it is characterized in that:It is by with prescribe medicine
Object
Mixing is made:Japan pepper essential oil 4ml, P-Cymene 2ml, Radix Glycyrrhizae essential oil 4ml, fruit of summer cypress essential oil 1.5ml, kuh-seng essential oil
2.5ml, root of Dahurain angelica essential oil 1.5ml, Snakegourd Fruit essential oil 2.5ml, Fructus Perillae quintessence oil 1.5ml, Peppermint essential oil 2.5ml and borneol 2g.
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| CN201810926128.9A CN108686023A (en) | 2018-08-15 | 2018-08-15 | A kind of antipruritic moisturizing essential oil for treating geroderma itch |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420242A (en) * | 2019-07-25 | 2019-11-08 | 南京中医药大学 | A kind of development of novel antipruritic essential oil |
| CN112120970A (en) * | 2020-09-29 | 2020-12-25 | 上海相宜本草化妆品股份有限公司 | Essential oil composition, preparation method and application thereof |
| CN113234345A (en) * | 2021-05-26 | 2021-08-10 | 中山市富日印刷材料有限公司 | Environment-friendly efficient cleaning agent and preparation method thereof |
Citations (1)
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| CN107875190A (en) * | 2017-12-25 | 2018-04-06 | 河南中医药大学 | A kind of Chinese medicine preparation essential oil of external curing senile skin itch |
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2018
- 2018-08-15 CN CN201810926128.9A patent/CN108686023A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875190A (en) * | 2017-12-25 | 2018-04-06 | 河南中医药大学 | A kind of Chinese medicine preparation essential oil of external curing senile skin itch |
Non-Patent Citations (1)
| Title |
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| 杨祖顺等: "一种杀菌气雾剂的消毒效果及毒性试验 ", 《中国消毒学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420242A (en) * | 2019-07-25 | 2019-11-08 | 南京中医药大学 | A kind of development of novel antipruritic essential oil |
| CN112120970A (en) * | 2020-09-29 | 2020-12-25 | 上海相宜本草化妆品股份有限公司 | Essential oil composition, preparation method and application thereof |
| CN112120970B (en) * | 2020-09-29 | 2023-02-03 | 上海相宜本草化妆品股份有限公司 | Chinese herbal medicine essential oil composition with permeation promoting effect, preparation method and application thereof |
| CN113234345A (en) * | 2021-05-26 | 2021-08-10 | 中山市富日印刷材料有限公司 | Environment-friendly efficient cleaning agent and preparation method thereof |
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