CN103585580B - A kind of Chinese medicine preparation for recurrent oral ulceration - Google Patents
A kind of Chinese medicine preparation for recurrent oral ulceration Download PDFInfo
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Abstract
The invention belongs to medical art, disclose a kind of Chinese medicine preparation for recurrent oral ulceration, it is prepared by following raw material and obtains, Indigo Naturalis 20 parts, the Radix Stemonae 18 parts, Herba Euphorbiae Humifusae 15 parts, Rhizoma Curcumae 15 parts, Fructus Trichosanthis 12 parts, Herba Scutellariae Barbatae 12 parts, Cortex Phellodendri 12 parts, Radix Platycodonis 10 parts, Fructus Gardeniae 10 parts, 10 parts, Radix Glycyrrhizae, the Radix Astragali 10 parts, Radix Ophiopogonis 10 parts, Fructus Mume 7 parts, Spica Prunellae 7 parts, Cortex Albiziae 5 parts, Semen Melo 5 parts, Ramulus Uncariae Cum Uncis 5 parts, 3 parts, Folium Mori.Chinese medicine preparation of the present invention is for the treatment short treating period of recurrent oral ulceration, and total effective rate is high, not easily recurs more, and technique is simple, reduces production cost, alleviates the financial burden of patient.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for recurrent oral ulceration, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Oral ulcer, is also called " aphtha ", is the superficial ulcer occurred on oral mucosa, large I from the grain of rice to Semen Glycines size, circular or oval, ulcer surface is that oral ulcer is recessed, congested around, and can cause pain because of irritable food, generally one or two week can spontaneous recovery.Oral ulcer becomes periodicity repeatedly to occur, and medically claims " recurrent oral ulceration ".Within 1 year, can fall ill for several times, also can fall ill several times for one month, even new and old pathological changes alternately occurs.Oral ulcer take periodic flare as feature, any position of oral mucosa can be occurred in, common with the mucosa at the places such as the lip in oral cavity, cheek, soft palate or gingiva, the single or multiple ellipse that differs in size or roun ulcer occur, and surface coverage greyish white or pattern pseudomembrane, concavity, around mucosa is red and micro-swollen, and ulcer local causalgia is obvious, has periodically, recurrent, the feature of self limiting.Although oral ulcer is " indisposition ", but it is painful and worried greatly to bring to patient and household thereof, after having suffered from oral ulcer, the normal diet of patient and work and rest are all interfered, and because pain causes, insomnia, spirit are irritated, anxiety, dejected, work and life all lose interest etc., especially recurrent oral ulceration, the economy caused to patient and mental burden are more heavy.
Doctor trained in Western medicine aspect, does not also have specific therapy for recurrent treatment oral ulcer, at present to eliminate paathogenic factor, mitigation symptoms, Promotive union, reduces recurrence, as the principle for the treatment of recurrent aphtha.Topical therapeutic: with antiinflammatory, pain relieving, Promotive union for principle.Common antibiotics, glucocorticoid, analgesic etc. make medicine film or with disinfecting liquid as rinsing the mouth oral cavities such as hibitane, boronic acid compound liquid, can antibacterial, sterilization, antiinflammatory, sterilization.For prolongedly not healing, pain obviously and larger area, adopt hormone local block therapy.Whole body therapeutic: carry out etiological treatment targetedly, if any the low person of cellular immune function, with immunostimulant if levamisole, transfer factor treatment are to improve curative effect; For recurrence, the frequent and state of an illness is compared with severe one or the ulcer that do not heal for a long time, and application immunosuppressant is treated.
China's traditional medicine thinks that recurrent oral ulceration has the following cause of disease to cause: one is diseases caused by exogenous pathogenic factor six climate exopathogens, mainly dry, fire two is evil, pathogenic dryness is dry and astringent, easy impairment of body fluid liquid, and fire belongs with yang is evil, and in its property inflammation, Tianjin wound fire burns, and aphtha is send out; Two is eating and drinking without temperances, due to product or the monophagia of the pungent plumpness of surfeit, causes endogenous fire formation, follow through on attack, stifling dispute, and cloudy Tianjin of the sad lung kidney of normal consumption, cause aphtha and occur; Three is emotional stresss, and patient is excessive thinking generally, dysphoria and insomnia, the strongly fragrant and fire-transformation of five will, hyperactivity of heart-fire, the smoked dispute of burning of upper inflammation, or heart-fire moving downward is in small intestinal, follow through on attack Yu Kou, all can cause aphtha of the mouth and tongue; Four is that ferritic the moon loses, patient's ferritic YIN-fluid being insufficient, or prolonged illness the moon damages, deficiency-fire produced in the interior, dispute of burning, and even aphtha of the mouth and tongue; Five is overstrain internal injuries, or the prolonged illness impairment of the spleen, damage of spleen-QI, and water is wet not to be transported, upper stain dispute, and causes aphtha; Six is that congenital examining composes deficiency, or for a long time with cold and cool, injure spleen kidney, deficiency of spleen-YANG and kidneyYANG, yin-cold excess, stain dispute in cold-damp, blood stasis due to accumulation of cold, causes aphtha of the mouth and tongue for a long time.Diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire in a word, interior impairment of ZANG FU-organs intenseness of heat is pathogenic main cause, and the dirty of main disease is the heart and taste.
Assembly is newly square further on the basis of existing technology in the present invention, and provide a kind of technique simple, with low cost, medicament sources is widely used in the Chinese medicine preparation of recurrent oral ulceration.
Summary of the invention
The object of the invention is the newly side of further assembly on the basis of existing technology, provide a kind of technique simple, with low cost, regulate microcirculation, dredging the meridian, repair impaired mucosa, promote telangiectasis, improve immunity, medicament sources is widely used in the pharmaceutical composition of oral ulcer.
Present inventor is in conjunction with forefathers' formula and practice of practising medicine for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, by theory of Chinese medical science prescription, adopt natural Chinese medicines raw material, through systematic study, scientific compatibility, be meticulously mixed with the pure Chinese medicinal preparation for oral ulcer of the present invention in conjunction with Traditional Chinese Medicine technology, have to recurrent oral ulceration effect that As the medicine took effect, the symptoms lessened.
For achieving the above object, the technical solution used in the present invention is as follows:
For a Chinese medicine preparation for recurrent oral ulceration, it is prepared by the raw material of following weight parts and obtains,
Indigo Naturalis 20 parts, the Radix Stemonae 18 parts, Herba Euphorbiae Humifusae 15 parts, Rhizoma Curcumae 15 parts, Fructus Trichosanthis 12 parts,
Herba Scutellariae Barbatae 12 parts, Cortex Phellodendri 12 parts, Radix Platycodonis 10 parts, Fructus Gardeniae 10 parts, 10 parts, Radix Glycyrrhizae,
The Radix Astragali 10 parts, Radix Ophiopogonis 10 parts, Fructus Mume 7 parts, Spica Prunellae 7 parts, Cortex Albiziae 5 parts,
Semen Melo 5 parts, Ramulus Uncariae Cum Uncis 5 parts, 3 parts, Folium Mori.
Pharmaceutical composition of the present invention can adopt conventional method that the ingredients in prescription is carried out compatibility in proportion, and make various clinical applicable dosage form by existing preparation process, ingredients used is the Chinese crude drug that commercially available process is up to the standards.
Chinese medicine preparation preparation method of the present invention is:
(1) crude drug (proportioning unit: gram) of above-mentioned parts by weight is taken, for subsequent use;
(2) get the Radix Stemonae, Herba Euphorbiae Humifusae, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Glycyrrhizae, Spica Prunellae, Cortex Albiziae, Ramulus Uncariae Cum Uncis mix homogeneously, add the water soaking of 5 times of weight after 30 minutes, intense fire boils, then slow fire boiling 0.5 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 0.5 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.1-1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
(3) get Fructus Trichosanthis, Cortex Phellodendri, Radix Platycodonis, Fructus Gardeniae, the Radix Astragali, Radix Ophiopogonis, Fructus Mume, Semen Melo, Folium Mori add 70% soak with ethanol 0.5-1.5 hour, reflux, extract, twice, each 1-2 hour, merge extractive liquid, filter, be condensed into the extractum that density is 1.2g/ml, crushed after being dried, obtain complex B;
(4) Indigo Naturalis levigation is got, cross 80 mesh sieves, stir with complex A and complex B, get dry extract mixed powder, be the Chinese medicine preparation of the present invention for recurrent oral ulceration, usage and dosage: every day is coated with medicine of the present invention 3 times at ulcer surface, continuous use 5 days is a course for the treatment of, and period gives up alcohol, avoid chilli food.
The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, bring out the best in each other, invention formulation dose is little, and effective ingredient is easy to release, absorb fast, bioavailability is high, and drug effect is given full play to, through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, have a extensive future.
The excellent results of Chinese medicine composition of the present invention and preparation method thereof is:
1. medicament of the present invention is made up of pure Chinese medicine, and each component meets CP method relevant regulations, utilizes the compatibility effect of each taste Chinese medicine, not containing chemical components, not containing hormone, has no side effect, treating both the principal and secondary aspects of a disease;
2. this medicament short treating period, total effective rate is high, not easily recurs more;
3. technique of the present invention is simple, reduces production cost, alleviates the financial burden of patient.
Detailed description of the invention
Explained in details the present invention is carried out below by way of specific embodiment, but not as the restriction to content of the present invention.
Embodiment 1
For a Chinese medicine preparation for recurrent oral ulceration, it is prepared by the raw material of following weight parts and obtains,
Indigo Naturalis 20 parts, the Radix Stemonae 18 parts, Herba Euphorbiae Humifusae 15 parts, Rhizoma Curcumae 15 parts, Fructus Trichosanthis 12 parts,
Herba Scutellariae Barbatae 12 parts, Cortex Phellodendri 12 parts, Radix Platycodonis 10 parts, Fructus Gardeniae 10 parts, 10 parts, Radix Glycyrrhizae,
The Radix Astragali 10 parts, Radix Ophiopogonis 10 parts, Fructus Mume 7 parts, Spica Prunellae 7 parts, Cortex Albiziae 5 parts,
Semen Melo 5 parts, Ramulus Uncariae Cum Uncis 5 parts, 3 parts, Folium Mori,
Above-mentioned Chinese medicine preparation preparation method is:
(1) crude drug (proportioning unit: gram) of above-mentioned parts by weight is taken, for subsequent use;
(2) get the Radix Stemonae, Herba Euphorbiae Humifusae, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Glycyrrhizae, Spica Prunellae, Cortex Albiziae, Ramulus Uncariae Cum Uncis mix homogeneously, add the water soaking of 5 times of weight after 30 minutes, intense fire boils, then slow fire boiling 0.5 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 0.5 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.1g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
(3) get Fructus Trichosanthis, Cortex Phellodendri, Radix Platycodonis, Fructus Gardeniae, the Radix Astragali, Radix Ophiopogonis, Fructus Mume, Semen Melo, Folium Mori add 70% soak with ethanol 1.5 hours, reflux, extract, twice, each 2 hours, merge extractive liquid, filter, being condensed into density is 1.2g/ml
(4) Indigo Naturalis levigation is got, cross 80 mesh sieves, stir with complex A and complex B, get dry extract mixed powder, be the pure Chinese medicinal preparation of the present invention for recurrent oral ulceration, usage and dosage: every day is coated with medicine of the present invention 3 times at ulcer surface, continuous use three days is a course for the treatment of, and period gives up alcohol, avoid chilli food.
Embodiment 2
Experiment of Zoology
Mice carries out acute toxicity testing and shows in application: compare with matched group, after administration, mice has no notable difference, experiment Continuous Observation two weeks, mouse systemic situation, ingest, drink water, body weight growth is all normal.After the administration same day and administration in two weeks, have no animal dead, point out this medicine acute toxicity low, clinical drug safety.
Long term toxicity test
Select SD rat 40, male and female half and half.2 groups are divided at random, i.e. matched group (distilled water of Isodose), Chinese drug-treated group of the present invention according to body weight.Often organize 20, male and female half and half.Once, successive administration, after 1 month, cuts open and kills matched group and each 10 of Chinese drug-treated group of the present invention each treated animal gastric infusion every day; Convalescent period (drug withdrawal 2 weeks) is cutd open and kills matched group and each 10 of Chinese drug-treated group of the present invention.Duration of test observes outward appearance, general behavior, body weight change, food ration, the amount of drinking water of animal, within after administration 1 month, carries out the index checkings such as hematology, serum biochemistry, organ coefficient and histopathology with 2 weeks (convalescent period) of drug withdrawal.Result of the test shows: the general state of each treated animal is good, and outward appearance sign, behavioral activity, body weight increase change all without exception; Chinese drug-treated group of the present invention and matched group in administration hematological examination after 1 month, blood biochemical analysis inspection all in normal range, without significant difference between group; Each dosage group organ coefficient compares zero difference with matched group, and main organs tissue has no the Pathologic changes relevant to medicine.These parameters drug withdrawal also had no change after 2 weeks.The dose safety of prompting this product clinical practice is higher.
Embodiment 3
Clinical data:
Data and method: for investigating clinical efficacy and the safety of Chinese medicine preparation of the present invention further, we select 70 routine Blood of Patients with Recurrent Orals to carry out clinical observation to the curative effect of medicine of the present invention.Be divided into treatment group 35 example at random, matched group 35 example; Age 21-55 year, 32 years old mean age, male patient 33 example, female patient 37 example, between two groups, there is not significant difference in tool in sex, age, the course of disease etc., has comparability.
Inclusion criteria
(1) stomatocace recurrent exerbation (annual outbreak more than 10 times), continuous outbreak more than 1 year person (2) occurs in pain, scorching hot, the xerostomia halitosis of ulcer of lip, oral mucosa, gingiva, tongue body, ulcer number 1-5, oozes out as seen, hyperemia, edema etc. shows as master.
Therapeutic Method
Treatment group gives Chinese medicine preparation prepared by embodiment 1; Matched group kouyanqing granules 20g/ time, 2 times/day, warm water is taken after mixing it with water; All treat 5 days, judge curative effect for two groups.
Observation index, local disease damage evaluation criteria is as the criterion with ulcer change healing and the scorching hot degree of pain.
Cure: medication is transference cure after 5 days, and sign disappears substantially, ulcer disease damage all healed, and leading indicator integration is 0 or 1.
Effective: medication is transference cure after 5 days, and sign all has clear improvement, and ulcer healing reaches 2/3, or ulcer shoals and reduces, and integration leading indicator integration is 1, two is 2.
Effective: medication is transference cure after 5 days, and sign all take a favorable turn, ulcer healing reach 1/3 or ulcer shoal and reduce, integration leading indicator integration is 2, two is 3.
Invalid: medication cardinal symptom after 5 days, sign are improved not obvious, and ulcer is substantially unchanged, and main integration index is 3 or 4.
T inspection is adopted to carry out statistical procedures.
Through clinical observation, the cardinal symptom of recurrent oral ulceration in 5 days, can be improved: ulcer area, ulcer number, edema, canker sores, burning sensation, xerostomia and syndrome classification; Compare recurrent oral ulceration recovery from illness case Follow-up results, treatment group is better than matched group; Through two groups of experimenters, situation is improved to self-appraisal pain, pain is from the comparison of marking, the comparison for the treatment of front and back self-appraisal total score situation, the evaluation of curative effect and compare, and all has statistical significance, in table 1.
Table 1
Embodiment 4
Model case
Zheng, man, 49 years old, suffers from recurrent oral ulceration 2 years, often shows effect when irascible temperament.This shows effect about two weeks, external application BINGPENG SAN, the DeGrains such as oral vitamin C, vitamin B2.Quarter examines: unbearably, limit point 3 place's ulcer, large as Semen phaseoli radiati, little of the grain of rice, after holding a sinecure, gastral cavity is swollen, borborygmus loose stool, and red tongue, yellow fur are greasy in vain, soft and rapid pulse for the tip of the tongue causalgia.Card genus deficiency-weakness of spleen-QI, damp and hot middle resistance, coldheat complex, give pharmaceutical preparation prepared by embodiment 1, after three days, the tip of the tongue causalgia subtracts greatly, and after 5 days, ulcer disappears, and gastral cavity painful abdominal mass disappears, and food of receiving increases, and defecates rare, and continue bitterly only to take 3 days afterwards, stool is shaped, and follows up a case by regular visits to without recurring.
River: man, 31 years old, patient suffered from recurrent oral ulceration for many years, and doctor trained in Western medicine often treats weary effect with vitamins and antibiotic medicine, Chinese medicine or heat-clearing and toxic substances removing, or bitter cold is captured, or blood circulation promoting and blood stasis dispelling etc., also without small achievement.Disease is seen: the ulcer surface having two about 0.5cm × 0.8cm inside lower lip, and pain is obvious, and more very, causalgia unbearably in feed.Companion sees bitter taste, and mouth glues, and xerostomia is wish polydipsia not, and Mental fatigue limb is weary, perspiration and aversion to wind, and gastral cavilty creeping chill is obvious, and food of receiving is poor, and sleep not good enough, urine is slightly yellow, defecates partially dry, and light red tongue is dark, white thick greasy, the floating Huang of root of tongue fur, deep-thready pulse.Card belongs to: retention of damp-heat in the interior, spleen insufficiency.Control suitable: clearing away heat-fire, invigorating the spleen to clear away damp pathogen.Give Chinese medicine preparation prepared by embodiment 1, two days later, ulcer surface obviously reduces, pain relief, and mouth is not bitter but slightly sticky, gastral cavilty creeping chill makes moderate progress, but even has belch, receive can, take a turn for the better before sleep comparatively, after continuing to take 3 days, oral ulcer surface heals, and spirit takes a turn for the better, and all diseases alleviate, and follow up a case by regular visits to and do not recur.
Above-mentioned data have carried out detailed description to the specific embodiment of the present invention; but not limiting the scope of the invention; one of ordinary skill in the art should be understood that; on the basis of technical scheme of the present invention, those skilled in the art do not need to pay various amendment or distortion that creative work can make still within protection scope of the present invention.
Claims (1)
1., for a Chinese medicine preparation for recurrent oral ulceration, it is prepared by the raw material of following weight parts and obtains,
Indigo Naturalis 20 parts, the Radix Stemonae 18 parts, Herba Euphorbiae Humifusae 15 parts, Rhizoma Curcumae 15 parts, Fructus Trichosanthis 12 parts,
Herba Scutellariae Barbatae 12 parts, Cortex Phellodendri 12 parts, Radix Platycodonis 10 parts, Fructus Gardeniae 10 parts, 10 parts, Radix Glycyrrhizae,
The Radix Astragali 10 parts, Radix Ophiopogonis 10 parts, Fructus Mume 7 parts, Spica Prunellae 7 parts, Cortex Albiziae 5 parts,
Semen Melo 5 parts, Ramulus Uncariae Cum Uncis 5 parts, 3 parts, Folium Mori;
The preparation method of described Chinese medicine preparation comprises the steps:
(1) each raw material for standby is taken;
(2) get the Radix Stemonae, Herba Euphorbiae Humifusae, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Glycyrrhizae, Spica Prunellae, Cortex Albiziae, Ramulus Uncariae Cum Uncis, mix homogeneously, add the water soaking of 5 times of weight after 30 minutes, intense fire boils, then slow fire boiling 0.5 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 0.5 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.1-1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A:
(3) Fructus Trichosanthis, Cortex Phellodendri, Radix Platycodonis, Fructus Gardeniae, the Radix Astragali, Radix Ophiopogonis, Fructus Mume, Semen Melo, Folium Mori are got, add 70% soak with ethanol 0.5-1.5 hour, reflux, extract, twice, each 1-2 hour, merge extractive liquid, filters, is condensed into the extractum that density is 1.2g/ml, crushed after being dried, obtains complex B;
(4) get Indigo Naturalis levigation, cross 80 mesh sieves, stir with complex A and complex B, to obtain final product.
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| 复发性阿弗他溃疡辨证治疗八法;王志坤 等;《时珍国医国药》;20060828;第17卷(第08期);1547-1548 * |
| 栀子大黄汤治疗复发性口腔溃疡30例;陆守昌 等;《甘肃中医学院学报》;19991230;第16卷(第04期);35-36 * |
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