CN103191363B - Traditional Chinese medicine composition for treating infantile malnutrition and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating infantile malnutrition and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating infantile malnutrition. The traditional Chinese medicine composition is mainly composed of bighead atractylodes rhizome, endothelium corneum gigeriae galli, stone-like omphalia, Chinese torreya, Chinese olive, malt, aster, Chinese date, hawthorn, blackend swallowwort root, exocarpium citri rubrum, semen arecae prepareta, liquorice, Chinese yam, round cardamom and fructus amomi. By utilizing the traditional Chinese medicine composition, symptoms such as mental dysphoria, pale complexion and anorexia caused by the infantile malnutrition can be effectively relieved. The traditional Chinese medicine composition for treating the infantile malnutrition has the effects of helping digestion, tonifying spleen, invigorating stomach and soothing the nerves, has good therapeutic action on the infantile malnutrition, is safe and efficient, and does not have any side effects.
Description
Technical field
The invention discloses a kind of Chinese medicine composition, especially treat Chinese medicine composition of infantile malnutrition and preparation method thereof.The invention belongs to Chinese medicine field.
Background technology
Infantile malnutrition is children's's period, especially 1～5 years old child's a kind of common disease.Refer to due to improper feeding, or by the impact of various diseases, make taste impaired and cause asthenia universalis, the yellowish complexion of becoming thin, dried and withered hairs chronic diseases card.Infantile malnutrition is infantile malnutrition disease and stagnant general name.Infantile malnutrition disease refers to that, by improper feeding, taste are injured, affects the disease of growth promoter, is equivalent to dystrophic chronic disease.Stagnant is by breast food inner product, the impaired and gastroenteropathy that causes of taste, and it is clinical that to take diarrhoea or constipation, vomiting, abdominal distention be cardinal symptom.Ancients have the saying of " not becoming infantile malnutrition without amassing ", " amassing the mother into infantile malnutrition ".
The cause of disease of infantile malnutrition: 1, excess in feeding, injures taste.Excess in feeding, surfeit delicious food raw food, injures taste, and taste mistake department is received transformation failure of spleen, and lifting is uncomfortable, and becomes to stagnate.Stagnate with the passing of time, taste are more hindered, and are converted into infantile malnutrition; 2, Deficiency and coldness of spleen and stomach is weak.Deficiency and coldness of spleen and stomach is weak, and breast food is difficult to become thoroughly decomposed, and makes breast food stop amassing, and stops up poly-Central Region, hinders mechanism of qi, time day by day of a specified duration, cause nutritional disorder, it is thin that infant is won, gas-liquid void declines, dysplasia.Excess in feeding and weakness of the spleen and stomach reciprocal causation, stagnate and can injure taste, and weakness of the spleen and stomach can produce again stagnant, clinically many double mixing as disease mutually; 3, other.Some chronic disease and infection worm disease are often also the reason of primary disease.The traditional Chinese medical science refers to children's's emaciation and sallow complexion, and the disease that abdominal part expands, how by diet, does not have parasite to cause in restraining or abdomen.
The cardinal symptom of infantile malnutrition shows as emaciated physique, and body weight does not increase, abdominal part distension, poor appetite, lassitude, sleep uneasy night, defecates uncomfortable, normal foul smelling, thick fur is greasy, shallow complexion or pale, and hair is withered and yellow sparse, worn to a shadow, lethargy or agitation, doss not peaceful, and ululation is low little, extremity are not warm, dysplasia, abdominal retraction, diarrhea with loose stool, pale tongue with thin fur, fingerprint color is light.
The diagnosis basis of infantile malnutrition is: one, infantile malnutrition disease.1, diet is abnormal, and large dry stool is rare uncomfortable, or the obvious dysfunction of spleen and stomach person such as gastral cavity abdominal distention; 2, emaciated physique, body weight is lower than 15～40% of normal meansigma methods, lustreless complexion, hypotrichosis is withered and yellow, severe patient is withered win thin; 3, have lassitude concurrently, or hot-tempered, irritated irritability, or happiness rubs eyebrow brush eye, or suck the disease such as refer to grind one's teeth in sleep; 4, there are improper feeding or drinking and eating irregularly and the history of becoming thin for a long time after being ill; 5, because of ascarid causer, call it " malnutrition caused by ascariasis ", stool microscopy can be looked into and see roundworm egg; 6, anemia person, hemoglobin and erythrocytopenia; 7, occur limbs edema, belong to trophedema person, total serum protein amount is mostly below 45g/L, and serum albumin is below 20g/L.Two, stagnant.1, with anorexia, eat without digesting, abdominal part distension, diarrhea with loose stool or constipation are feature; 2, can be with dysphoria, cry and scream night or the disease such as vomiting; 3, there is dyspepsia due to improper feeding history; 4, the stool visible indigestion food debris of laboratory examination and fat drop.
Summary of the invention
One of object of the present invention is to provide a kind of Chinese medicine composition for the treatment of infantile malnutrition, have evident in efficacy, have no side effect, the feature of suitable children taking, and its adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned treatment infantile malnutrition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for infantile malnutrition, preferred proportioning, takes off the primary raw material of stating weight proportion and is prepared from: Rhizoma Atractylodis Macrocephalae 6-12 part, Endothelium Corneum Gigeriae Galli 3-9 part, Omphalia 15-21 part, Semen Torreyae 9-15 part, Fructus Canarii 4-9 part, Fructus Hordei Germinatus 9-15 part, Radix Asteris 5-9 part, Fructus Jujubae 6-15 part, Fructus Crataegi 6-12 part, Radix Cynanchi Atrati 4-9 part, Exocarpium Citri Rubrum 3-9 part, Semen Arecae Prepareta 3-9 part, Radix Glycyrrhizae 1.5-9 part, Rhizoma Dioscoreae 15-30 part, Fructus Amomi Rotundus 3-6 part, Fructus Amomi 3-6 part.
Treat a Chinese medicine composition for infantile malnutrition, more preferably proportioning, takes off the primary raw material of stating weight proportion and is prepared from: Rhizoma Atractylodis Macrocephalae 8-10 part, Endothelium Corneum Gigeriae Galli 5-8 part, Omphalia 17-20 part, Semen Torreyae 10-14 part, Fructus Canarii 5-8 part, Fructus Hordei Germinatus 10-14 part, Radix Asteris 6-8 part, Fructus Jujubae 7-13 part, Fructus Crataegi 7-10 part, Radix Cynanchi Atrati 5-8 part, Exocarpium Citri Rubrum 4-7 part, Semen Arecae Prepareta 4-8 part, Radix Glycyrrhizae 2-7 part, Rhizoma Dioscoreae 18-25 part, Fructus Amomi Rotundus 4-5 part, Fructus Amomi 4-5 part.
Treat a Chinese medicine composition for infantile malnutrition, best proportioning, takes off the primary raw material of stating weight proportion and is prepared from: 9 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Endothelium Corneum Gigeriae Galli, 18 parts of Omphalias, 12 parts of Semen Torreyaes, 6 parts of Fructus Canariis, 12 parts, Fructus Hordei Germinatus, 7 parts of Radix Asteriss, 12 parts, Fructus Jujubae, 8 parts of Fructus Crataegis, 6 parts of Radix Cynanchi Atratis, 6 parts of Exocarpium Citri Rubrums, 5 parts of Semen Arecae Preparetas, 4 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Dioscoreaes, 4.5 parts, Fructus Amomi Rotundus, 4 parts of Fructus Amomis.
A preparation method for the treatment of infantile malnutrition Chinese medicine composition, preparation process is as follows:
1. the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Omphalia, Semen Torreyae, Fructus Canarii, Fructus Hordei Germinatus, Radix Asteris, Fructus Jujubae, Fructus Crataegi, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Semen Arecae Prepareta, Radix Glycyrrhizae are placed in non iron container, decoct with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 40 minutes again, add Fructus Amomi Rotundus and Fructus Amomi, decoct again 20 minutes, standing, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption be filtrate quality 0.5-1.5 doubly, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.30-1.40;
3. Rhizoma Dioscoreae is made to powder, cross mesh sieve, add step 2. in the thick paste of gained;
4. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 3. in gained thick paste stirring and evenly mixing, be modulated into hands and pinch agglomeratingly, gently press loose soft material, soft material is crossed mesh sieve, makes wet granular;
5. the wet granular bake drying of 4. step being made, baking temperature is 60 ℃-80 ℃, cooling rear dried particles is crossed 12 mesh sieves, seals stand-by.
5. the preparation method of above-mentioned Chinese medicine composition, step 1. standing 22-28 hour (preferably standing 25 hours), filters again.
6. the preparation method of above-mentioned Chinese medicine composition, step 2. ethanol consumption is the 0.8-1.2 doubly (preferred alcohol consumption is 1.0 times of filtrate quality) of filtrate quality.
7. the preparation method of above-mentioned Chinese medicine composition, 2. step continues to be concentrated into thick paste again, to relative density be 1.33-1.38(preferably to relative density be 1.35).
8. the preparation method of above-mentioned Chinese medicine composition, 3. step makes powder by Rhizoma Dioscoreae, crosses 95-105 mesh sieve (preferably 100 mesh sieves).
9. the preparation method of above-mentioned Chinese medicine composition, step 4. soft material is crossed 11-13 mesh sieve (preferably soft material is crossed 12 mesh sieves), makes wet granular.
10. the preparation method of above-mentioned Chinese medicine composition, step 5. baking temperature is 65 ℃-75 ℃ (preferably baking temperature is 70 ℃).
Using method: for making the present invention reach optimum therapeuticing effect, Chinese medicine composition of the present invention was got 12 grams in one hour after meal morning, noon and afternoon every day and taken after mixing it with water with boiled water.
Treat a Chinese medicine composition for infantile malnutrition, the pharmacological effect of each crude drug is respectively:
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Have invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, edema.
Endothelium Corneum Gigeriae Galli: sweet in the mouth, property is flat.The effect that has invigorating the stomach and promoting digestion, arresting seminal emission, does not disappear for food stagnation, and vomiting is had loose bowels, infantile malnutrition.
Omphalia: mildly bitter flavor, cold in nature.The effect that has killing insect and eliminating accumulation, for cestode, ancylostome, ascariasis, infantile malnutrition.
Semen Torreyae: sweet in the mouth, property is flat.The effect that has killing insect and eliminating accumulation, moistening dryness for relaxing bowels, for ancylostome, ascariasis, infantile malnutrition, constipation.
Fructus Canarii: sweet in the mouth, acid, property is flat.The effect that has relieving sore-throat by clearing away heat, promotes the production of body fluid and detoxify, for laryngopharynx swelling and pain, cough, excessive thirst.
Fructus Hordei Germinatus: sweet in the mouth, property is flat.There is spleen benefiting and stimulating the appetite, move back the effect of newborn relieving distension, for food stagnation, do not disappear, women's ablactation.
Radix Asteris: acrid in the mouth, hardship, warm in nature.Have nourishing the lung to keep the adverse QI downward, under cough the only effect of expectorant, for abundant expectoration cough, new chronic cough is coughed.
Fructus Jujubae: sweet in the mouth, warm in nature, there is the effect of invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature.The effect that has promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, for meat stagnation, gastral cavilty distension, dysentery stomachache.
Radix Cynanchi Atrati: bitter in the mouth, salty, cold in nature.The effect that has clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment, for fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive disease heat, the heating of pathogenic warmth wound battalion.
Exocarpium Citri Rubrum: acrid in the mouth, hardship, warm in nature.The effect that has cold expelling, dampness, promoting the circulation of QI, expectorant, for cough due to wind and cold, itching of the throat abundant expectoration, food stagnation, vomiting and nausea painful abdominal mass is vexed.
Semen Arecae Prepareta: bitter in the mouth, pungent, warm in nature.The effect that has dyspepsia and intestinal stasis relieving, does not disappear for food stagnation, heavy after dysentery.
Radix Glycyrrhizae: sweet in the mouth, property is flat.The effect that has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, lassitude, shortness of breath and palpitation.
Rhizoma Dioscoreae: sweet in the mouth, property is flat.Have spleen reinforcing nourishing the stomach, the effect of the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the loose stool of having loose bowels.
Fructus Amomi Rotundus: acrid in the mouth, warm in nature.Have the disappear effect of painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving of removing dampness, for turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, food stagnation does not disappear.
Fructus Amomi: acrid in the mouth, warm in nature.There are removing dampness appetizing, warming spleen and stopping diarrha effect, for turbid damp obstructing in middle-JIAO, Deficiency and coldness of spleen and stomach, vomiting is had loose bowels, and wrist painful abdominal mass is not hungry.
The principle of Chinese medicine composition of the present invention based on traditional Chinese medical herbal treatment infantile malnutrition, the Chinese medicinal material property of medicine of selecting is gentle, and all has the long-pending effect that helps digestion, cheap again, life-time service also can not cause patient's financial burden, is the comparatively desirable medicine for the treatment of infantile malnutrition.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1treat a Chinese medicine composition for infantile malnutrition, get following traditional Chinese medicine raw medicine: 6 grams of the Rhizoma Atractylodis Macrocephalaes, 3 grams of Endothelium Corneum Gigeriae Galli, 15 grams of Omphalias, 9 grams of Semen Torreyaes, 4 grams of Fructus Canariis, 9 grams, Fructus Hordei Germinatus, 5 grams of Radix Asteriss, 6 grams, Fructus Jujubae, 6 grams of Fructus Crataegis, 4 grams of Radix Cynanchi Atratis, 3 grams of Exocarpium Citri Rubrums, 3 grams of Semen Arecae Preparetas, 1.5 grams, Radix Glycyrrhizae, 15 grams of Rhizoma Dioscoreaes, 3 grams, Fructus Amomi Rotundus, 3 grams of Fructus Amomis.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Omphalia, Semen Torreyae, Fructus Canarii, Fructus Hordei Germinatus, Radix Asteris, Fructus Jujubae, Fructus Crataegi, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Semen Arecae Prepareta, Radix Glycyrrhizae are placed in non iron container, decoct with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 40 minutes again, add Fructus Amomi Rotundus and Fructus Amomi, decoct again 20 minutes, standing 20 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 0.5 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.30;
3. Rhizoma Dioscoreae is made to powder, cross 90 mesh sieves, add step 2. in the thick paste of gained;
4. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 3. in gained thick paste stirring and evenly mixing, be modulated into hands and pinch agglomeratingly, gently press loose soft material, soft material is crossed 10 mesh sieves, makes wet granular;
5. the wet granular bake drying of 4. step being made, baking temperature is 60 ℃, cooling rear dried particles is crossed 12 mesh sieves, seals stand-by.
model case onewoods XX, man, 4 Guangrao County, Sui， Dongying city.Symptom: patient's yellowish complexion of becoming thin, brittle hair, has a poor appetite, abdominal part distension, also lethargy always, ate anthelmintic drug, and laying several ，Qu hospitals of ascarid is infantile malnutrition after diagnosing.Sick age: 1 year.Examine the time: on July 25th, 2011; For making the present invention reach optimum therapeuticing effect, Chinese medicine composition of the present invention was got 12 grams in one hour after meal morning, noon and afternoon every day and is taken after mixing it with water with boiled water.Take abdominal part distension transference cure 15 days; Take 40 days, appetite starts to increase, and mental status is clearly better, and takes 3 months, and brittle hair symptom is clearly better; Continue to take 5 months, weight in patients starts to increase, and face is replied normal, recovers; After take again Chinese medicine composition of the present invention and consolidate curative effect 1 month, drug withdrawal is so far without recurrence.
embodiment 2treat a Chinese medicine composition for infantile malnutrition, get following traditional Chinese medicine raw medicine: 8 grams of the Rhizoma Atractylodis Macrocephalaes, 5 grams of Endothelium Corneum Gigeriae Galli, 17 grams of Omphalias, 10 grams of Semen Torreyaes, 5 grams of Fructus Canariis, 10 grams, Fructus Hordei Germinatus, 6 grams of Radix Asteriss, 7 grams, Fructus Jujubae, 7 grams of Fructus Crataegis, 5 grams of Radix Cynanchi Atratis, 4 grams of Exocarpium Citri Rubrums, 4 grams of Semen Arecae Preparetas, 2 grams, Radix Glycyrrhizae, 18 grams of Rhizoma Dioscoreaes, 4 grams, Fructus Amomi Rotundus, 4 grams of Fructus Amomis.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Omphalia, Semen Torreyae, Fructus Canarii, Fructus Hordei Germinatus, Radix Asteris, Fructus Jujubae, Fructus Crataegi, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Semen Arecae Prepareta, Radix Glycyrrhizae are placed in non iron container, decoct with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 40 minutes again, add Fructus Amomi Rotundus and Fructus Amomi, decoct again 20 minutes, standing 22 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 0.8 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.35;
3. Rhizoma Dioscoreae is made to powder, cross 110 mesh sieves, add step 2. in the thick paste of gained;
4. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 3. in gained thick paste stirring and evenly mixing, be modulated into hands and pinch agglomeratingly, gently press loose soft material, soft material is crossed 12 mesh sieves, makes wet granular;
5. the wet granular bake drying of 4. step being made, baking temperature is 65 ℃, cooling rear dried particles is crossed 12 mesh sieves, seals stand-by.
model case twowu XX, female, 1 Zichuan District, Zibo City, Sui Ban， Shandong Province.Symptom: after patient is born 3 months, cry and scream normal night, sleep disorder, anorexia, vomiting, abdominal part overflow, build is partially thin, do not increase, by hospital diagnosis, be infantile malnutrition.Sick age: 7 months.Examine the time: on October 16th, 2011; For making the present invention reach optimum therapeuticing effect, Chinese medicine composition of the present invention was got 12 grams in one hour after meal morning, noon and afternoon every day and is taken after mixing it with water with boiled water.Take 20 days, cry and scream night, and sleep disorder symptom is clearly better; Take 1 first quarter moon, appetite increases, vomiting, abdominal part overflow resolution of symptoms; Take 3 months, new hair grows, and body weight starts to increase, and every ill symptoms disappears completely, recovers; After take again Chinese medicine composition of the present invention and consolidate curative effect 1 month, drug withdrawal is so far without recurrence.
embodiment 3treat a Chinese medicine composition for infantile malnutrition, get following traditional Chinese medicine raw medicine: 10 grams of the Rhizoma Atractylodis Macrocephalaes, 8 grams of Endothelium Corneum Gigeriae Galli, 20 grams of Omphalias, 14 grams of Semen Torreyaes, 8 grams of Fructus Canariis, 14 grams, Fructus Hordei Germinatus, 8 grams of Radix Asteriss, 13 grams, Fructus Jujubae, 10 grams of Fructus Crataegis, 8 grams of Radix Cynanchi Atratis, 7 grams of Exocarpium Citri Rubrums, 8 grams of Semen Arecae Preparetas, 7 grams, Radix Glycyrrhizae, 25 grams of Rhizoma Dioscoreaes, 5 grams, Fructus Amomi Rotundus, 5 grams of Fructus Amomis.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Omphalia, Semen Torreyae, Fructus Canarii, Fructus Hordei Germinatus, Radix Asteris, Fructus Jujubae, Fructus Crataegi, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Semen Arecae Prepareta, Radix Glycyrrhizae are placed in non iron container, decoct with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 40 minutes again, add Fructus Amomi Rotundus and Fructus Amomi, decoct again 20 minutes, standing 28 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 1.2 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.40;
3. Rhizoma Dioscoreae is made to powder, cross 100 mesh sieves, add step 2. in the thick paste of gained;
4. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 3. in gained thick paste stirring and evenly mixing, be modulated into hands and pinch agglomeratingly, gently press loose soft material, soft material is crossed 14 mesh sieves, makes wet granular;
5. the wet granular bake drying of 4. step being made, baking temperature is 75 ℃, cooling rear dried particles is crossed 12 mesh sieves, seals stand-by.
embodiment 4treat a Chinese medicine composition for infantile malnutrition, get following traditional Chinese medicine raw medicine: 12 grams of the Rhizoma Atractylodis Macrocephalaes, 9 grams of Endothelium Corneum Gigeriae Galli, 21 grams of Omphalias, 15 grams of Semen Torreyaes, 9 grams of Fructus Canariis, 15 grams, Fructus Hordei Germinatus, 9 grams of Radix Asteriss, 15 grams, Fructus Jujubae, 12 grams of Fructus Crataegis, 9 grams of Radix Cynanchi Atratis, 9 grams of Exocarpium Citri Rubrums, 9 grams of Semen Arecae Preparetas, 9 grams, Radix Glycyrrhizae, 30 grams of Rhizoma Dioscoreaes, 6 grams, Fructus Amomi Rotundus, 6 grams of Fructus Amomis.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Omphalia, Semen Torreyae, Fructus Canarii, Fructus Hordei Germinatus, Radix Asteris, Fructus Jujubae, Fructus Crataegi, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Semen Arecae Prepareta, Radix Glycyrrhizae are placed in non iron container, decoct with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 40 minutes again, add Fructus Amomi Rotundus and Fructus Amomi, decoct again 20 minutes, standing 30 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 1.5 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.40;
3. Rhizoma Dioscoreae is made to powder, cross 120 mesh sieves, add step 2. in the thick paste of gained;
4. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 3. in gained thick paste stirring and evenly mixing, be modulated into hands and pinch agglomeratingly, gently press loose soft material, soft material is crossed 14 mesh sieves, makes wet granular;
5. the wet granular bake drying of 4. step being made, baking temperature is 80 ℃, cooling rear dried particles is crossed 12 mesh sieves, seals stand-by.
model case threeliu XX, man, 6 Huimin County, Accessories during Binzhou, Sui， Shandong Province.Patient always coughs, and easily has a fever, and appetite starts to reduce, and abdominal distention, and lassitude are hot-tempered, sleep unreal, and health is obviously become thin, and complexion is wax yellow, and hypotrichosis ，Qu hospital is infantile malnutrition after diagnosing.Sick age: 8 months.Examine the time: on JIUYUE 26th, 2011; Chinese medicine composition of the present invention was got 12 grams in one hour after meal morning, noon and afternoon every day and is taken after mixing it with water with boiled water.Take 10 days, cough remission, fever symptoms disappears; Take 25 days, cough disappears, and appetite is normal, takes 2 months, and mental status takes a turn for the better, and evening, sleep was normal; Take 3 15th day of a month, complexion is normal, and it is dense that hair recovers, and every ill symptoms disappears completely, recovers; During taking Chinese medicine composition of the present invention, have no adverse reaction, drug withdrawal is so far without recurrence.
embodiment 5treat a Chinese medicine composition for infantile malnutrition, get following traditional Chinese medicine raw medicine: 9 grams of the Rhizoma Atractylodis Macrocephalaes, 6 grams of Endothelium Corneum Gigeriae Galli, 18 grams of Omphalias, 12 grams of Semen Torreyaes, 6 grams of Fructus Canariis, 12 grams, Fructus Hordei Germinatus, 7 grams of Radix Asteriss, 12 grams, Fructus Jujubae, 8 grams of Fructus Crataegis, 6 grams of Radix Cynanchi Atratis, 6 grams of Exocarpium Citri Rubrums, 5 grams of Semen Arecae Preparetas, 4 grams, Radix Glycyrrhizae, 20 grams of Rhizoma Dioscoreaes, 4.5 grams, Fructus Amomi Rotundus, 4 grams of Fructus Amomis.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Omphalia, Semen Torreyae, Fructus Canarii, Fructus Hordei Germinatus, Radix Asteris, Fructus Jujubae, Fructus Crataegi, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Semen Arecae Prepareta, Radix Glycyrrhizae are placed in non iron container, decoct with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 40 minutes again, add Fructus Amomi Rotundus and Fructus Amomi, decoct again 20 minutes, standing 25 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 1.0 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.35;
3. Rhizoma Dioscoreae is made to powder, cross 100 mesh sieves, add step 2. in the thick paste of gained;
4. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 3. in gained thick paste stirring and evenly mixing, be modulated into hands and pinch agglomeratingly, gently press loose soft material, soft material is crossed 12 mesh sieves, makes wet granular;
5. the wet granular bake drying of 4. step being made, baking temperature is 70 ℃, cooling rear dried particles is crossed 12 mesh sieves, seals stand-by.
Using method: for making the present invention reach optimum therapeuticing effect, Chinese medicine composition of the present invention was got 12 grams in one hour after meal morning, noon and afternoon every day and taken after mixing it with water with boiled water.
experimental example
In April 1 year May in 2011, have 200 patients and use.Inclusion criteria: be diagnosed as the child of infantile malnutrition, age 1-4 year.200 patients are divided into two large groups at random, experimental group and matched group, and experimental group is used embodiment 5 gained Chinese medicine compositions, and got 12 grams inferior to one hour after meal morning, noon and afternoon every day and take after mixing it with water with boiled water every day three.Matched group is used western medicine.All take 30 days as 1 course for the treatment of, after 4 courses for the treatment of, evaluate curative effect for two groups.
Main symptom, the sign Index investigated: (1) appetite recovery situation: appetite is obviously improved number; (2) mental restoration situation; (3) body weight gain situation: getting and respectively organizing weight in patients average before treatment is basic data, after treatment cycle finishes, again gets and respectively organizes data comparison before weight in patients average and treatment; (4) other indexs of health
Curative effect situation criterion: 1, cure: symptom disappears completely; 2, effective: cardinal symptom obviously alleviates, and health indices recovers to some extent; 3, invalid: with before treatment, compare, each side all improves without obvious
Table 1: before and after two groups of treatments, clinical symptoms sign is evaluated situation comparison
| Observation item | Time | Body weight increases (%) | Appetite situation (people) |
| Experimental group 100 people | After treatment | 15% | 95 |
| Matched group 100 people | After treatment | 8% | 75 |
Note: in upper table, body weight increase percent and appetite situation data are all taken the mean.
Result: before and after two groups of treatments, clinical symptoms signs are evaluated situation comparison, and after treatment, 2 curative effect indexs of two groups of patients all make moderate progress, and experimental group improves successful and is better than matched group.
Table 2: two groups of Clinical efficacy comparisons [example (%)]
| Group | Case load | Clinical cure | Effectively | Invalid | Cure rate | Total effective rate |
| Matched group | 100 | 35 | 53 | 12 | 35% | 88% |
| Experimental group | 100 | 60 | 39 | 1 | 60% | 99% |
Result: two groups of Clinical efficacy comparisons, matched group cure rate is 35%, total effective rate is 88%; Matched group cure rate is 60%, and total effective rate is that 99%, two group of Clinical efficacy comparison shows that experimental group curative effect is better than matched group.
Through clinical trial, prove, use Chinese medicine composition of the present invention, can improve fast and effectively infantile malnutrition child's appetite and mental status, can comparatively comprehensively treat infantile malnutrition, the object that reaches reduction of patient misery, conditioning patient body is a kind of Chinese medicine composition for the treatment of safely and effectively infantile malnutrition.
Claims (16)
1. a Chinese medicine composition for the treatment of infantile malnutrition, is characterized in that, takes off the raw material of stating weight proportion and is prepared from: Rhizoma Atractylodis Macrocephalae 6-12 part, Endothelium Corneum Gigeriae Galli 3-9 part, Omphalia 15-21 part, Semen Torreyae 9-15 part, Fructus Canarii 4-9 part, Fructus Hordei Germinatus 9-15 part, Radix Asteris 5-9 part, Fructus Jujubae 6-15 part, Fructus Crataegi 6-12 part, Radix Cynanchi Atrati 4-9 part, Exocarpium Citri Rubrum 3-9 part, Semen Arecae Prepareta 3-9 part, Radix Glycyrrhizae 1.5-9 part, Rhizoma Dioscoreae 15-30 part, Fructus Amomi Rotundus 3-6 part, Fructus Amomi 3-6 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the raw material of stating weight proportion and is prepared from: Rhizoma Atractylodis Macrocephalae 8-10 part, Endothelium Corneum Gigeriae Galli 5-8 part, Omphalia 17-20 part, Semen Torreyae 10-14 part, Fructus Canarii 5-8 part, Fructus Hordei Germinatus 10-14 part, Radix Asteris 6-8 part, Fructus Jujubae 7-13 part, Fructus Crataegi 7-10 part, Radix Cynanchi Atrati 5-8 part, Exocarpium Citri Rubrum 4-7 part, Semen Arecae Prepareta 4-8 part, Radix Glycyrrhizae 2-7 part, Rhizoma Dioscoreae 18-25 part, Fructus Amomi Rotundus 4-5 part, Fructus Amomi 4-5 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the raw material of stating weight proportion and is prepared from: 9 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Endothelium Corneum Gigeriae Galli, 18 parts of Omphalias, 12 parts of Semen Torreyaes, 6 parts of Fructus Canariis, 12 parts, Fructus Hordei Germinatus, 7 parts of Radix Asteriss, 12 parts, Fructus Jujubae, 8 parts of Fructus Crataegis, 6 parts of Radix Cynanchi Atratis, 6 parts of Exocarpium Citri Rubrums, 5 parts of Semen Arecae Preparetas, 4 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Dioscoreaes, 4.5 parts, Fructus Amomi Rotundus, 4 parts of Fructus Amomis.
4. according to the preparation method of the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, step is as follows:
1. the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli, Omphalia, Semen Torreyae, Fructus Canarii, Fructus Hordei Germinatus, Radix Asteris, Fructus Jujubae, Fructus Crataegi, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Semen Arecae Prepareta, Radix Glycyrrhizae are placed in non iron container, decoct with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 40 minutes again, add Fructus Amomi Rotundus and Fructus Amomi, decoct again 20 minutes, standing, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption be filtrate quality 0.5-1.5 doubly, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.30-1.40;
3. Rhizoma Dioscoreae is made to powder, sieve, add step 2. in the thick paste of gained;
4. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 3. in gained thick paste stirring and evenly mixing, be modulated into hands and pinch agglomeratingly, gently press loose soft material, soft material sieves, and makes wet granular;
5. the wet granular bake drying of 4. step being made, baking temperature is 60 ℃-80 ℃, cooling rear dried particles is crossed 12 mesh sieves, seals stand-by.
5. preparation method according to claim 4, is characterized in that, step is standing 22-28 hour 1., again filters.
6. preparation method according to claim 5, is characterized in that, step 1. standing 25 hours is filtered again.
7. preparation method according to claim 4, is characterized in that, step 2. ethanol consumption be filtrate quality 0.8-1.2 doubly.
8. preparation method according to claim 7, is characterized in that, step 2. ethanol consumption is 1.0 times of filtrate quality.
9. preparation method according to claim 4, is characterized in that, 2. step continues to be concentrated into thick paste again, to relative density be 1.33-1.38.
10. preparation method according to claim 9, is characterized in that, 2. step continues to be concentrated into thick paste again, to relative density be 1.35.
11. preparation methoies according to claim 4, is characterized in that, 3. step makes powder by Rhizoma Dioscoreae, cross 95-105 mesh sieve.
12. preparation methoies according to claim 11, is characterized in that, 3. step makes powder by Rhizoma Dioscoreae, cross 100 mesh sieves.
13. preparation methoies according to claim 4, is characterized in that, step 4. soft material is crossed 11-13 mesh sieve, makes wet granular.
14. preparation methoies according to claim 13, is characterized in that, step 4. soft material is crossed 12 mesh sieves, makes wet granular.
15. preparation methoies according to claim 4, is characterized in that, step 5. baking temperature is 65 ℃-75 ℃.
16. preparation methoies according to claim 15, is characterized in that, step 5. baking temperature is 70 ℃.
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| CN101584834A (en) * | 2008-05-21 | 2009-11-25 | 彭洋法 | Traditional Chinese medicine for treating infantile malnutrition with parasitic infestation |
| CN101766765A (en) * | 2008-12-30 | 2010-07-07 | 北京中科仁和科技有限公司 | Granule for treating children indigestion |
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| CN101766765A (en) * | 2008-12-30 | 2010-07-07 | 北京中科仁和科技有限公司 | Granule for treating children indigestion |
| CN101934039A (en) * | 2010-08-28 | 2011-01-05 | 穆志明 | Medicament for treating spleen deficiency and dyspepsia stomach and intestine |
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