CN101766765A - Granule for treating children indigestion - Google Patents
Granule for treating children indigestion Download PDFInfo
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- CN101766765A CN101766765A CN200810241086A CN200810241086A CN101766765A CN 101766765 A CN101766765 A CN 101766765A CN 200810241086 A CN200810241086 A CN 200810241086A CN 200810241086 A CN200810241086 A CN 200810241086A CN 101766765 A CN101766765 A CN 101766765A
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Abstract
The invention discloses a granule for treating children indigestion, belonging to the pharmaceutical field of the traditional Chinese medicine. The granule comprises radix codonopsis, radix astragali, largehead atractylodes rhizome, Tuckahoe, rhizoma dioscoreae, pericarpium citri reticulatae, rhizoma alismatis, fructus crataegi, endothelium corneum gigeriae galli, malt and radix glycyrrhizae, which are scientifically made into granules. The granule has the advantages of invigorating the spleen, replenishing qi and promoting the digestion, and can be used for treating the children indigestion with manifestations of emaciatioon with yellowish complexion, abdominal distension and anorexia, and the like. Through efficacy experiment, the result shows that the granule can obviously improve the pepsin activity, the gastric free acid and the total gastric acid and promote the intestinal peristalsis, and have the good efficacy of treating the children indigestion.
Description
Technical field
The present invention relates to a kind of granule, be specifically related to a kind of granule for the treatment of infantile dyspepsia, belong to Chinese medicine pharmaceutical technology field.
Background technology
Dyspepsia be a kind of be common disease in children disease by the caused disease of gastric motility disorder, epigastric discomfort sense or pain appear after being usually expressed as when feed or food; After feed, motion or flat the crouching, there are burn feeling or acid regurgitation in the upper abdomen center, and may extend to pharyngeal; Often feel glutted or the flatulence sense is arranged, have the hiccups, passwind and increase; Inappetence, nauseating, laxativeness etc.
Primary disease often needs for a long time, medication repeatedly, and treatment time is long, the expense height.Current more existing both at home and abroad treat the conventional Western medicine of this disease, as motilium, cisapride, metoclopramide and Ondansetron etc., better curative effect is arranged, but because the state of an illness is easy to repeatedly, and certain side effect is arranged, as the side effect of motilium to central nervous system, extrapyramidal system, loose stool and diarrhoea etc. can appear in cisapride, and its late result also remains further to be improved.The Chinese patent medicine for the treatment of such disease clinically is also more, as adds flavor lenitive pill, Aurantii Immaturi and Atractylodis Pill, oral mushroom liquor etc., and still, physiological characteristics old, the child is that internal organs are tender and lovely, weakness of the spleen and stomach particularly, to drug reaction than healthy people's sensitivity.Therefore, particularly preschool children's uses medicines such as adding flavor lenitive pill, Aurantii Immaturi and Atractylodis Pill, oral mushroom liquor to be, and is just more outstanding to adverse effect.
Summary of the invention
The objective of the invention is to overcome the deficiency of existing preparation, a kind of granule for the treatment of infantile dyspepsia is provided, comprise this particulate processing technology.
The present invention is achieved by the following technical solutions:
A kind of granule for the treatment of infantile dyspepsia, it is that raw material is made by following parts by weight of Chinese traditional medicine material:
Radix Codonopsis 25-80 weight portion Radix Astragali 15-60 weight portion Rhizoma Atractylodis Macrocephalae 30-60 weight portion
Poria 60-100 weight portion Rhizoma Dioscoreae 10-50 weight portion Pericarpium Citri Reticulatae 45-70 weight portion
Rhizoma Alismatis 25-70 weight portion Fructus Crataegi 20-70 weight portion Endothelium Corneum Gigeriae Galli 35-80 weight portion
Fructus Hordei Germinatus 30-85 weight portion Radix Glycyrrhizae 20-60 weight portion.
And the weight portion proportioning of described each Chinese crude drug raw material is:
The Radix Codonopsis 60 weight portion Radixs Astragali 45 weight portion Rhizoma Atractylodis Macrocephalaes 45 weight portions
Poria 80 weight portion Rhizoma Dioscoreaes 30 weight portion Pericarpium Citri Reticulataes 55 weight portions
Rhizoma Alismatis 50 weight portion Fructus Crataegis 40 weight portion Endothelium Corneum Gigeriae Galli 55 weight portions
Fructus Hordei Germinatus 60 weight portion Radix Glycyrrhizaes 40 weight portions.
Its processing technology is:
(1) each pulverizing medicinal materials is become coarse powder, standby;
(2) get the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae coarse powder, mix, water vapour distillation volatile oil, medicinal residues and distillation back water liquid are standby; The volatile oil beta-cyclodextrin inclusion compound, lyophilization, standby;
(3) get all the other nine flavors such as Radix Codonopsis, the Radix Astragali and mix, soak a few hours, add the medicinal residues and the aqueous solution of (2), fry in shallow oil altogether 2～5 times, gained decocting liquid filters, and filtrate is condensed into thick paste, and drying under reduced pressure gets dry extract, and is standby;
(4) collect dried cream, put coldly, pulverize, sieve, it is an amount of to add proper auxiliary materials, granulates, and adds volatile oil clathrate compound, mix homogeneously, and packing, promptly.
Function of the present invention cures mainly and is: invigorating the spleen and benefiting QI, removing food stagnancy is good for the stomach.Be used for infantile dyspepsia, disease is met yellow leanness, lack of appetite abdominal distention etc.
For beneficial effect of the present invention better is described, we have carried out following pharmacodynamics test research:
The principal agent side that adopts is: Radix Codonopsis 60g, and Radix Astragali 45g, Rhizoma Atractylodis Macrocephalae 45g, Poria 80g, Rhizoma Dioscoreae 30g, Pericarpium Citri Reticulatae 55g, Rhizoma Alismatis 50g, Fructus Crataegi 40g, Endothelium Corneum Gigeriae Galli 55g, Fructus Hordei Germinatus 60g, Radix Glycyrrhizae 40g makes granule according to preparation method of the present invention.
1 test material
1.1 test drug and reagent granule of the present invention, XIAOER XISHI PIAN, hydrochloric acid, sodium hydroxide.
1.2 laboratory animal SD rat, Kunming mouse.
2 test methods and result
2.1 to the pepsic influence of rat gastric acid
40 of rats; body weight 150～200g; male and female half and half; evenly be divided into 4 groups at random; gavage large and small dosage granule suspension of the present invention respectively; the XIAOER XISHI PIAN suspension reaches the normal saline with volume; administration every day 1 time; successive administration 7 days, in rat fasting (can't help water) in the 6th day, in the end after 1 administration 2h with 20% urethane anesthetized rat (rat fasting 12h); dissect rat abdomen; insert the plastic tube that a diameter is 3mm from the pylorus end to gastric, near the pylorus ball place's ligation fix, to collect gastric juice.And by oral cavity helmet before esophagus inserts with a plastic tube, with the esophagus ligation, with 35 ℃ of left and right sides normal saline, carry out the gastric perfusion with peristaltic pump by the speed of 12ml/h and collect, collection 1h eluate is standby.
2.1.1 influence to the rat stomach proteinase activity
The hydrochloric acid 2ml that gets eluate 2ml and 0.1mol is in test tube, mixing, adding three of protein pipe in every test tube (gets interior through 1mm, long 10cm, the capillary tube of even thickness makes it fill fresh Ovum Gallus domesticus album with siphonage, no bubble in the pipe, be placed on then in 80 ℃ of left and right sides water heaters and make protein coagulation, take out standby).With the good test tube mouth of defat tampon, in 37 ± 1 ℃ of calorstats, hatch 24h, measure the length (mm) that protein pipe immerses the end transparent part, get three end sums and ask its meansigma methods, calculate peptic activity of stomach (pepsin unit=meansigma methods
2* 16), the results are shown in Table 1.
Table 1 granule of the present invention to the rat stomach proteinase activity influence the result (x ± s, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with the normal saline group
The result shows that the large and small dosage group of granule of the present invention all can significantly improve pepsin activity (P＜0.01), and effect is better than the XIAOER XISHI PIAN group.
2.1.2 influence to rat free acid and total acidity
Get eluate 2ml, put in the small beaker, add each 3 of dimethyl yellow indicator and phenolphthalein indicators, mixing (being cherry red), slowly splash into sodium hydroxide volumetric solution (0.02mol/L) with burette then, to the redness that phenolphthalein occurs (color is no longer deepened), record sodium hydroxide volumetric solution consumption.The sodium hydroxide sum that consumes is total acidity terminal point amount, calculates free acid amount and total acidity as follows, the results are shown in Table 2.
Gastric juice amount * 1000 are got in free acid amount (mol/L)=(0.02 * free acid terminal point amount)/titration
Gastric juice amount * 1000 are got in total acidity (mol/L)=(0.02 * total acidity terminal point amount)/titration
Table 2 granule of the present invention to stomach free acid and total acid content influence the result (x ± s, n=10)
Annotate: compare * P＜0.05, * * P＜0.05 with the normal saline group
The result shows that the large and small dosage group of granule of the present invention all can obviously improve stomach free acid amount and total acid content (P＜0.05, P＜0.01), and effect is better than the XIAOER XISHI PIAN group.
2.2 influence to the mouse small intestine motion
40 of mices; body weight 18～20g; male and female half and half; evenly be divided into 4 groups at random; gavage big respectively; low dose of granule suspension of the present invention; the XIAOER XISHI PIAN suspension reaches the normal saline with volume, administration every day 1 time, successive administration 5 days; in mice fasting (can't help water) in the 4th day; do experiment behind the fasting 12h, 20min after last 1 administration, every Mus adds irritates the physiological salt liquid that contains 10% active carbon; the perfusion amount is the 0.2ml/10g body weight; irritate back 20min, put to death mice immediately, dissect rapidly and take out small intestinal; be tiled in the absorbent paper; survey the powdered carbon front end in enteral advance distance and small intestinal total length (pylorus is to ileocecus length), and calculate powdered carbon propelling percentage rate as follows, the results are shown in Table 3.
Powdered carbon advances percentage rate (%)=powdered carbon to advance length/small intestinal total length * 100%
Table 3 granule of the present invention to mouse small intestine motion influence the result (x ± s, n=10)
Annotate: compare * P＜0.05 with the normal saline group
The result shows that the large and small dosage group of granule of the present invention can promote intestinal motility, make powdered carbon advance percentage rate obviously to improve, and effect is better than the XIAOER XISHI PIAN group.
3 conclusions
Originally studies show that granule of the present invention can obviously improve pepsin activity, significantly improve stomach free acid and stomach total acid content and promote the enterokinesia effect, and effect is better than the XIAOER XISHI PIAN group.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment:
Adopt following prescription:
[prescription 1]:
Radix Codonopsis 30g Radix Astragali 18g Rhizoma Atractylodis Macrocephalae 30g
Poria 60g Rhizoma Dioscoreae 12g Pericarpium Citri Reticulatae 45g
Rhizoma Alismatis 25g Fructus Crataegi 20g Endothelium Corneum Gigeriae Galli 40g
Fructus Hordei Germinatus 35g Radix Glycyrrhizae 22g.
[prescription 2]:
Radix Codonopsis 60g Radix Astragali 45g Rhizoma Atractylodis Macrocephalae 45g
Poria 80g Rhizoma Dioscoreae 30g Pericarpium Citri Reticulatae 55g
Rhizoma Alismatis 50g Fructus Crataegi 40g Endothelium Corneum Gigeriae Galli 55g
Fructus Hordei Germinatus 60g Radix Glycyrrhizae 40g.
[prescription 3]:
Radix Codonopsis 75g Radix Astragali 60g Rhizoma Atractylodis Macrocephalae 55g
Poria 100g Rhizoma Dioscoreae 50g Pericarpium Citri Reticulatae 70g
Rhizoma Alismatis 70g Fructus Crataegi 70g Endothelium Corneum Gigeriae Galli 80g
Fructus Hordei Germinatus 85g Radix Glycyrrhizae 50g.
Its processing technology is:
(1) each pulverizing medicinal materials is become coarse powder, standby;
(2) get the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae coarse powder, mix, water vapour distillation volatile oil, medicinal residues and distillation back water liquid are standby; The volatile oil beta-cyclodextrin inclusion compound, lyophilization, standby;
(3) getting all the other nine flavors such as Radix Codonopsis, the Radix Astragali mixes, soaked 4 hours, add the medicinal residues and the aqueous solution of (2), fry in shallow oil altogether 3 times, add the water of 10 times of amount medical materials at every turn, each 1 hour, gained decocting liquid filters, and filtrate is condensed into 60 ℃ of heat, and to survey relative densities be 1.35 thick paste, drying under reduced pressure, get dry extract, standby;
(4) collect dried cream, put coldly, pulverize, sieve, it is an amount of to add cane sugar powder and dextrin, and water is granulated, and it is an amount of to add volatile oil clathrate compound and Pulvis Talci, mix homogeneously, and packing, promptly.
Claims (4)
1. granule for the treatment of infantile dyspepsia is characterized in that it is that raw material is made by following parts by weight of Chinese traditional medicine material:
Radix Codonopsis 25-80 weight portion Radix Astragali 15-60 weight portion Rhizoma Atractylodis Macrocephalae 30-60 weight portion
Poria 60-100 weight portion Rhizoma Dioscoreae 10-50 weight portion Pericarpium Citri Reticulatae 45-70 weight portion
Rhizoma Alismatis 25-70 weight portion Fructus Crataegi 20-70 weight portion Endothelium Corneum Gigeriae Galli 35-80 weight portion
Fructus Hordei Germinatus 30-85 weight portion Radix Glycyrrhizae 20-60 weight portion.
2. a kind of granule for the treatment of infantile dyspepsia according to claim 1, wherein the weight portion proportioning of each Chinese crude drug raw material is:
The Radix Codonopsis 60 weight portion Radixs Astragali 45 weight portion Rhizoma Atractylodis Macrocephalaes 45 weight portions
Poria 80 weight portion Rhizoma Dioscoreaes 30 weight portion Pericarpium Citri Reticulataes 55 weight portions
Rhizoma Alismatis 50 weight portion Fructus Crataegis 40 weight portion Endothelium Corneum Gigeriae Galli 55 weight portions
Fructus Hordei Germinatus 60 weight portion Radix Glycyrrhizaes 40 weight portions.
3. according to each described a kind of granule for the treatment of infantile dyspepsia of claim 1-2, its processing technology is:
(1) each pulverizing medicinal materials is become coarse powder, standby;
(2) get the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae coarse powder, mix, water vapour distillation volatile oil, medicinal residues and distillation back water liquid are standby; The volatile oil beta-cyclodextrin inclusion compound, lyophilization, standby;
(3) get all the other nine flavors such as Radix Codonopsis, the Radix Astragali and mix, soak a few hours, add the medicinal residues and the aqueous solution of (2), fry in shallow oil altogether 2～5 times, gained decocting liquid filters, and filtrate is condensed into thick paste, and drying under reduced pressure gets dry extract, and is standby;
(4) collect dried cream, put coldly, pulverize, sieve, it is an amount of to add proper auxiliary materials, granulates, and adds volatile oil clathrate compound, mix homogeneously, and packing, promptly.
4. according to each described a kind of granule for the treatment of infantile dyspepsia of claim 1-2, its function cures mainly and is: have invigorating the spleen and benefiting QI, a function of the removing food stagnancy that is good for the stomach, be used for infantile dyspepsia, disease is met yellow leanness, lack of appetite abdominal distention etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810241086A CN101766765A (en) | 2008-12-30 | 2008-12-30 | Granule for treating children indigestion |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810241086A CN101766765A (en) | 2008-12-30 | 2008-12-30 | Granule for treating children indigestion |
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Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905014A (en) * | 2010-08-03 | 2010-12-08 | 中国农业科学院上海兽医研究所 | Traditional Chinese medicine compound composition for treating diarrhea of weaned piglets |
| CN101934039A (en) * | 2010-08-28 | 2011-01-05 | 穆志明 | Medicament for treating spleen deficiency and dyspepsia stomach and intestine |
| CN102423435A (en) * | 2011-12-12 | 2012-04-25 | 钱家美 | Chinese medicine for treating infantile malnutrition and preparation method thereof |
| CN102631596A (en) * | 2012-04-30 | 2012-08-15 | 李承平 | Medicine composition with functions of tonifying spleen and nourishing stomach |
| CN103191363A (en) * | 2013-04-12 | 2013-07-10 | 杨邱月 | Traditional Chinese medicine composition for treating infantile malnutrition and preparation method of traditional Chinese medicine composition |
| CN103300360A (en) * | 2013-05-16 | 2013-09-18 | 吴永金 | Endothelium corneum instant granule and preparation method thereof |
| CN103621938A (en) * | 2013-11-27 | 2014-03-12 | 泸州百草堂健康产品有限公司 | Food, health-care product or medicinal composition for improving gastronintestinal digestion function |
| CN103656447A (en) * | 2013-11-21 | 2014-03-26 | 黄萍 | Traditional Chinese medicine composite for treating pediatric dyspepsia |
| CN103783509A (en) * | 2013-12-31 | 2014-05-14 | 陈慧婷 | Endothelium corneum gigeriae galli-yam dispersible tablet and preparation method thereof |
| CN104161264A (en) * | 2014-08-13 | 2014-11-26 | 王金枝 | Medicated diet prescription for postoperative rehabilitation of gallstones and preparation method thereof |
| CN104383502A (en) * | 2014-12-01 | 2015-03-04 | 范影 | Traditional Chinese medicine formula for treating infantile dyspepsia |
| CN104398726A (en) * | 2014-10-22 | 2015-03-11 | 蔺洪俊 | Traditional Chinese medicine for treating diarrhea and preparing method thereof |
| CN105396067A (en) * | 2015-12-14 | 2016-03-16 | 张翠华 | Prescription for treating infantile dyspepsia and preparation method thereof |
| CN107296915A (en) * | 2017-08-15 | 2017-10-27 | 汕头市鼎铭堂健康食品有限公司 | A kind of draft preserves baby's tea and preparation method thereof |
| CN108245668A (en) * | 2018-01-09 | 2018-07-06 | 成都通德药业有限公司 | A kind of preparation method of compound Pepsin |
| CN115868626A (en) * | 2022-12-23 | 2023-03-31 | 宝利康生物科技(天津)有限公司 | Medicinal and edible solid beverage for treating gallstones and preparation method thereof |
-
2008
- 2008-12-30 CN CN200810241086A patent/CN101766765A/en active Pending
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905014A (en) * | 2010-08-03 | 2010-12-08 | 中国农业科学院上海兽医研究所 | Traditional Chinese medicine compound composition for treating diarrhea of weaned piglets |
| CN101934039A (en) * | 2010-08-28 | 2011-01-05 | 穆志明 | Medicament for treating spleen deficiency and dyspepsia stomach and intestine |
| CN102423435A (en) * | 2011-12-12 | 2012-04-25 | 钱家美 | Chinese medicine for treating infantile malnutrition and preparation method thereof |
| CN102423435B (en) * | 2011-12-12 | 2013-05-01 | 钱家美 | Chinese medicine for treating infantile malnutrition and preparation method thereof |
| CN102631596A (en) * | 2012-04-30 | 2012-08-15 | 李承平 | Medicine composition with functions of tonifying spleen and nourishing stomach |
| CN103191363A (en) * | 2013-04-12 | 2013-07-10 | 杨邱月 | Traditional Chinese medicine composition for treating infantile malnutrition and preparation method of traditional Chinese medicine composition |
| CN103191363B (en) * | 2013-04-12 | 2014-03-12 | 杨邱月 | Traditional Chinese medicine composition for treating infantile malnutrition and preparation method of traditional Chinese medicine composition |
| CN103300360A (en) * | 2013-05-16 | 2013-09-18 | 吴永金 | Endothelium corneum instant granule and preparation method thereof |
| CN103656447A (en) * | 2013-11-21 | 2014-03-26 | 黄萍 | Traditional Chinese medicine composite for treating pediatric dyspepsia |
| CN103621938B (en) * | 2013-11-27 | 2015-05-20 | 泸州百草堂健康产品有限公司 | Food, health-care product or medicinal composition for improving gastronintestinal digestion function |
| CN103621938A (en) * | 2013-11-27 | 2014-03-12 | 泸州百草堂健康产品有限公司 | Food, health-care product or medicinal composition for improving gastronintestinal digestion function |
| CN103783509A (en) * | 2013-12-31 | 2014-05-14 | 陈慧婷 | Endothelium corneum gigeriae galli-yam dispersible tablet and preparation method thereof |
| CN103783509B (en) * | 2013-12-31 | 2016-02-17 | 陈慧婷 | A kind of Endothelium Corneum Gigeriae Galli Chinese yam dispersible tablet and preparation method |
| CN104161264A (en) * | 2014-08-13 | 2014-11-26 | 王金枝 | Medicated diet prescription for postoperative rehabilitation of gallstones and preparation method thereof |
| CN104398726A (en) * | 2014-10-22 | 2015-03-11 | 蔺洪俊 | Traditional Chinese medicine for treating diarrhea and preparing method thereof |
| CN104383502A (en) * | 2014-12-01 | 2015-03-04 | 范影 | Traditional Chinese medicine formula for treating infantile dyspepsia |
| CN105396067A (en) * | 2015-12-14 | 2016-03-16 | 张翠华 | Prescription for treating infantile dyspepsia and preparation method thereof |
| CN107296915A (en) * | 2017-08-15 | 2017-10-27 | 汕头市鼎铭堂健康食品有限公司 | A kind of draft preserves baby's tea and preparation method thereof |
| CN108245668A (en) * | 2018-01-09 | 2018-07-06 | 成都通德药业有限公司 | A kind of preparation method of compound Pepsin |
| CN115868626A (en) * | 2022-12-23 | 2023-03-31 | 宝利康生物科技(天津)有限公司 | Medicinal and edible solid beverage for treating gallstones and preparation method thereof |
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Application publication date: 20100707 |