CN102885895A - Traditional Chinese medicinal composition for strengthening gastrointestinal mobility and method for preparing traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for strengthening gastrointestinal mobility and method for preparing traditional Chinese medicinal composition Download PDFInfo
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- CN102885895A CN102885895A CN2012104404931A CN201210440493A CN102885895A CN 102885895 A CN102885895 A CN 102885895A CN 2012104404931 A CN2012104404931 A CN 2012104404931A CN 201210440493 A CN201210440493 A CN 201210440493A CN 102885895 A CN102885895 A CN 102885895A
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Abstract
The invention discloses a traditional Chinese medicinal composition for strengthening gastrointestinal mobility and a method for preparing the traditional Chinese medicinal composition for strengthening gastrointestinal mobility, belonging to the field of traditional Chinese medicines. The traditional Chinese medicines namely fructum artemisiae argyi, microcos paniculata, stephanotis and white perilla leaf are taken as raw materials to be combined to prepare active ingredients, and the active ingredients and common pharmaceutical adjuncts are prepared into an oral preparation. The traditional Chinese medicinal composition can strengthen the insufficient gastrointestinal mobility and has an exact curative function on gastrointestinal malfunction.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that strengthens digestive tract power that embodies, belong to the field of Chinese medicines.
Background technology
In the digestive system, gastrointestinal tract is one of significant points, and it is the digestion of human body dietary intake and the main position of absorption of nutrient ingredients; Stomach is the part of expanding most in the digestive tract, plays the effect of temporary storage food, digestion part food; Small intestinal is to digest and assimilate most important position in the digestive tract, is the important absorption site of human nutrition, and the various Digestive systems of secreting in the small intestinal digest the food that is advanced by stomach again, and transmit postdigestive material to large intestine.
Dewater in the human pickuping food, the small-molecule substances such as inorganic salt, vitamin can be directly absorbed by the body outside, other macromole nutrient substance such as protein, sugar, fat etc. all need to occur series reaction and are decomposed into the digested road of ability mucosa absorption behind the small-molecule substance in digestive tract; The acid digestion liquid that gastric is secreted can help digest absorption, and gastric juice mainly comprises hydrochloric acid, pepsin and mucus etc., and the sour environment that hydrochloric acid causes can make pepsin normally play a role; The intestinal fluid of the enteraden of mucous membrane of small intestine secretion contains multiple digestive enzyme, and these enzymes match with digestive enzyme in the bile, the material that can be absorbed sugar, fatty, proteopepsis one-tenth by intestinal wall; Large intestine is mainly postdigestive residual substance the temporary storage place is provided.In the whole digestion process behind the human pickuping food, if digestive tract power and function are normal, digest and assimilate normally, nutritional sufficiency will cause a series of diseases such as digestive tract power and functional disorder, such as various symptoms such as abdominal distention, dyspepsia, constipation; Long-term digestive tract power is not normal, digestive function is unusual, to bring nutrient substance to lack and cause other diseases, and so whether digestive tract power and function thereof are one of key factors of health normally, will effectively strengthen digestive tract power and can play and improve body symptom and nutriture effect.
Chinese invention patent publication number CN102362970A discloses " a kind of Chinese medicine composition and preparation technology thereof who improves gastrointestinal function ", and adopting Aloe, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Aurantii is the raw material preparation, mainly for the not normal constipation symptom of gastrointestinal function; Chinese invention patent publication number CN1302564A discloses " a kind of preparation method that strengthens health food and this health food of gastrointestinal function and beauty treatment ", adopts Radix Angelicae Sinensis, Radix Paeoniae Rubra, Poria, Flos Carthami, Aloe, vitamin E, vitamin B
2For raw material through pulverize, sieve, the technique preparations such as mixing, fill capsule, although have certain effect to strengthening gastrointestinal function and beauty treatment, encapsulated with crude drug, gastrointestinal is had certain stimulation; Chinese invention patent publication number CN101450074 discloses " a kind of obvious gastrointestinal function, anti-compositions that treats constipation improved ", adopt oligomeric xylose, biological calcium carbonate, vitamin C, milk flavour preparation, this forms non-Chinese crude drug composition combination, and the effect major embodiment strengthens the defecating feces excretion of gastrointestinal function.
The present invention is the Chinese medicine composition that strengthens the digestive tract power effect that has that screening obtains from Chinese crude drug, can reach facilitating digestion and absorb the effect of loosening bowel to relieve constipation; Compare with Western medicine, it is little to have toxic and side effects, is suitable for the advantage of long-term taking, is suitable for digestive tract power deficiency and dysfunction crowd.
Summary of the invention
The object of the invention provides a kind of Chinese medicine composition, and by the rational proportion of each medical material, synergism strengthens digestive tract power, and digestive tract power deficiency and functional disorder are caused that disease has fine prevention and therapeutic effect under Chinese medical theory instructs.
Another one purpose of the present invention provides this Chinese medicine composition preparation method.
The traditional Chinese medical science thinks that the major function of stomach is received and digesting food, main logical falling; The major function of small intestinal is reservoir and transformation, separates the useful from the waste; The major function of large intestine is transporting waste.The symptoms such as belch, vomiting, abdominal distention, diarrhoea, dysentery or constipation will appear such as gastrointestinal dysfunction.Spleen and stomach phase the exterior and the interior, the heart and the small intestine share a paired relationship, the lung and the large intestine being interior-exteriorly related is so whether also dirty closely related with spleen, lung, the heart three gastrointestinal function is normally.
The Chinese medicine composition of enhancing digestive tract power of the present invention, selecting Fructum Artemisiae Argyi, Folium Microcoris paniculatae, Radix Stephaniae Cepharanthae, Folium Perillae Frutescentis is raw material; Wherein Fructum Artemisiae Argyi bitter in the mouth, suffering are warm in nature, have stomach warming and middle effect; Lightly seasoned, the little acid of Folium Microcoris paniculatae, property is flat, has the effect of eliminating indigestion and phlegm; Radix Stephaniae Cepharanthae bitter in the mouth, property suffering, cool are returned spleen, lung, kidney channel, have the clearing away heat to alleviate pain effect; Folium Perillae Frutescentis acrid in the mouth, warm in nature is returned lung, spleen channel, has the effect that helps digestion of regulating the flow of vital energy.Above-mentioned all medicines share, and reach the effect of Activating Qi and regulating stomach to relieve pain, and the digestive tract power deficiency is played the enhancing action of enterogastric function.
The raw material consumption of preparation medicine activity component of the present invention is: Fructum Artemisiae Argyi 5-30 part, Folium Microcoris paniculatae 5-30 part, Radix Stephaniae Cepharanthae 5-30 part, Folium Perillae Frutescentis 5-30 part.Be preferably 12 parts of Fructum Artemisiae Argyi, 12 parts of Folium Microcoris paniculataes, 12 parts of Radix Stephaniae Cepharanthaes, 12 parts of Folium Perillae Frutescentiss.
Chinese medicine composition of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into conventional oral formulations.
With 12 parts of Fructum Artemisiae Argyi, 12 parts of Folium Microcoris paniculataes, 12 parts of Radix Stephaniae Cepharanthaes, 12 parts of Folium Perillae Frutescentiss, mix according to above-mentioned weight ratio, add 6-8 times of water gaging and soaked 1-2 hour, heating decocted 1.5 hours, filtered, medicinal residues add 5-6 times of water gaging heating again and decocted 1 hour, filter, merge filtrate twice, left standstill 1 hour, pour out supernatant, supernatant concentration is to relative density 1.08-1.10, and preferred density is 1.09, advances spray dryer, 130-140 ℃ of inlet temperature control, preferred 135 ℃, leaving air temp 100-110 ℃, preferred 105 ℃, 30-40 rev/min of nebulizer rotating speed, preferred 35 rev/mins, charging rate is 3-5 ml/ minute, preferred 4ml/ minute, get spray drying powder, can get fine powder behind the crushing screening.
The various conventional adjuvant of needs when this fine powder can add the preparation different dosage form, as: lubricant, binding agent etc. are prepared into the common Chinese medicine preparation formulation with conventional method of Chinese medicinal, such as tablet, capsule, granule etc.
The invention will be further elaborated below in conjunction with embodiment
Embodiment 1 capsule preparation of the present invention (take ten times of material proportional quantities as example)
1. take by weighing each crude drug by following weight proportion
120 parts of Fructum Artemisiae Argyi, 120 parts of Folium Microcoris paniculataes, 120 parts of Radix Stephaniae Cepharanthaes, 120 parts of Folium Perillae Frutescentiss are for subsequent use;
2. the Fructum Artemisiae Argyi of above-mentioned weight proportion, Folium Microcoris paniculatae, Radix Stephaniae Cepharanthae, Folium Perillae Frutescentis add 8 times of water gagings immersions 2 hours, and heating decocted 1.5 hours, filter, and medicinal residues add 6 times of water gagings heating decoctions 1 hour again, filter, and merge filtrate twice, leave standstill 1 hour, pour out supernatant;
3. above-mentioned supernatant concentration to relative density is 1.1 o'clock, advances spray dryer, 140 ℃ of inlet temperature controls, and 110 ℃ of leaving air temps, 40 rev/mins of nebulizer rotating speeds, charging rate is 5 ml/ minutes, gets spray drying powder;
4. above-mentioned spray drying powder adds adjuvant, mixing, the snap fit capsule of packing into.
Embodiment 2 tablet preparations of the present invention (take ten times of material proportional quantities as example)
1. take by weighing each crude drug by following weight proportion
120 parts of Fructum Artemisiae Argyi, 120 parts of Folium Microcoris paniculataes, 120 parts of Radix Stephaniae Cepharanthaes, 120 parts of Folium Perillae Frutescentiss are for subsequent use;
2. the Fructum Artemisiae Argyi of above-mentioned weight proportion, Folium Microcoris paniculatae, Radix Stephaniae Cepharanthae, Folium Perillae Frutescentis add 6 times of water gagings immersions 1 hour, and heating decocted 1.5 hours, filter, and medicinal residues add 5 times of water gagings heating decoctions 1 hour again, filter, and merge filtrate twice, leave standstill 1 hour, pour out supernatant;
3. above-mentioned supernatant concentration to relative density is 1.08 o'clock, advances spray dryer, 130 ℃ of inlet temperature controls, and 100 ℃ of leaving air temps, 30 rev/mins of nebulizer rotating speeds, charging rate is 3 ml/ minutes, gets spray drying powder;
4. pulverize above-mentioned spray drying powder and become fine powder, add the adjuvant granulation, drying, tabletting.
The Ergonomy evaluation experimental of experimental example 1 Chinese medicine composition of the present invention
1. Chinese medicine composition of the present invention is on the impact of experiment mice small intestinal charcoal end propelling rate
48 of the healthy Kunming mouses of cleaning level, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups, and namely gavage gives the matched group of Insta-Char, high, medium and low three the dosage groups of above-mentioned traditional Chinese medicine composition water decocting liquid, 12 every group.
Adopt conventional decocting method to prepare the present composition, and the simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (20g/kg), middle dosage group (10g/kg), low dose group (5g/kg).
Respectively organize the mice fasting before the experiment, press different group gastric infusions during experiment, equal gavage is given 5% Insta-Char (the arabic gum preparation with 10%) 0.1ml/10g body weight behind the 1h, put to death animal behind the 20min, cut open the belly and take out small intestinal, tractive is not tiled on the flat board, the length of measurement from the pylorus to the caecum is the small intestinal overall length, measure again the front end to the reach of charcoal end from pylorus, calculate the percentage rate that its length accounts for the small intestinal overall length, i.e. charcoal end ink propulsive rate.Charcoal end ink propulsive rate=charcoal end advance distance/small intestinal overall length.The results are shown in Table 1.
Chinese medicine composition of the present invention is on the impact of Mouse Stomach emptying time
40 of the healthy Kunming mouses of cleaning level, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups at random, i.e. matched group, high, medium and low three the dosage groups of above-mentioned traditional Chinese medicine composition water decocting liquid, 12 every group.
Adopt conventional decocting method preparation, and the simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (20g/kg), middle dosage group (10g/kg), low dose group (5g/kg).
Each group of experiment proxima luce (prox. luc) is by fasting 24h behind the corresponding group mediating recipe amount gastric infusion, and after 2h was administered once again before the experiment, every mouse stomach was given 0.1% methyl orange aqueous solution 0.2ml.Put to death animal behind the 20min, win stomach, place beaker, add the 10ml distilled water, stomach is cut off along greater gastric curvature, content is fully washed in the distilled water, use Na
2HCO
3Regulate pH value 6.0 ~ 6.5, get supernatant after centrifugal, with 741 type ultraviolet-visible photometers under wavelength 420nm, add the 10ml distilled water with 0.1% methyl orange, 0.2 ml and make radix, respectively organize methyl orange trap in the Mouse Stomach, and calculate by following formula and respectively to organize in the Mouse Stomach average methyl orange residual rate.Methyl orange trap A/ methyl orange trap radix * 100% in methyl orange residual rate=stomach.The results are shown in Table 1.
Table 1 Chinese medicine composition of the present invention on mouse small intestine charcoal end propelling rate and the impact in gastric emptying time (
± s, n=12)
| Group | Number of animals | Dosage (g/kg) | Charcoal end propelling rate (%) | Methyl orange residual rate (%) in the stomach |
| Matched group | 12 | 0.0 | 33.21±4.15 | 41.35±3.52 |
| Low dose group | 12 | 5.0 | 42.58±3.51* | ?38.22±3.22* |
| Middle dosage group | 12 | 10.0 | 45.77±3.25* | ?33.51±4.02* |
| High dose group | 12 | 20.0 | 49.85±5.02* | ?28.23±4.14* |
* representative is compared with matched group
P＜0.05
Chinese medicine composition of the present invention is obvious on methyl orange residual rate impact in the mouse small intestine charcoal end propelling rate stomach function regulating, and high, medium and low three dosage groups and matched group relatively have significant difference
P＜0.05, this presentation of results Chinese medicine composition of the present invention can promote the propelling at charcoal end in the small intestinal, reduces the residual rate of methyl orange in the stomach; Point out Chinese medicine composition of the present invention can promote intestinal motility and promotion gastric peristalsis.
Claims (4)
1. Chinese medicine composition that improves gastrointestinal function, the active component that it is characterized in that it is to be made by the crude drug of following weight portion: Fructum Artemisiae Argyi 5-30 part, Folium Microcoris paniculatae 5-30 part, Radix Stephaniae Cepharanthae 5-30 part, Folium Perillae Frutescentis 5-30 part.
2. according to claim 1 Chinese medicine composition, wherein the consumption of each crude drug is: 12 parts of Fructum Artemisiae Argyi, 12 parts of Folium Microcoris paniculataes, 12 parts of Radix Stephaniae Cepharanthaes, 12 parts of Folium Perillae Frutescentiss.
3. the preparation method of Chinese medicine composition according to claim 1 and 2, it is for subsequent use to comprise the steps: to take by weighing each crude drug Fructum Artemisiae Argyi, Folium Microcoris paniculatae, Radix Stephaniae Cepharanthae, Folium Perillae Frutescentis; Fructum Artemisiae Argyi, Folium Microcoris paniculatae, Radix Stephaniae Cepharanthae, Folium Perillae Frutescentis by above-mentioned weight proportion mix according to above-mentioned weight ratio, add 6-8 times of water gaging and soak 1-2 hour, and heating decocted 1.5 hours, filter, medicinal residues add 5-6 times of water gaging heating again and decocted 1 hour, filter, merge filtrate twice, left standstill 1 hour, get supernatant; Supernatant concentration is advanced spray dryer to relative density 1.08-1.10,130-140 ℃ of inlet temperature control, and leaving air temp 100-110 ℃, 30-40 rev/min of nebulizer rotating speed, charging rate is 3-5 ml/ minute, gets spray drying powder; Pulverize spray drying powder, get fine powder, the i.e. active component of this Chinese medicine composition after sieving.
4. preparation method according to claim 3 is mixed active component and the pharmaceutical preparation adjuvant commonly used that makes, and is prepared into tablet, capsule, granule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055783A (en) * | 2015-08-28 | 2015-11-18 | 广州国宇医药科技有限公司 | Traditional Chinese medicine composition for improving gastrointestinal functions |
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| CN1672714A (en) * | 2004-03-24 | 2005-09-28 | 伍锦成 | Gastrointestinal tea |
| CN1768788A (en) * | 2005-10-26 | 2006-05-10 | 广西灵峰药业有限公司 | Formulation for treating gastrointestinal disease and production method thereof |
| CN101444615A (en) * | 2008-11-24 | 2009-06-03 | 律北平 | Chinese traditional medical formula taken orally for curing acute enteritis |
| CN101816764A (en) * | 2010-05-06 | 2010-09-01 | 中山市新运来医药科技开发有限公司 | Chinese medicament granule preparation for warming kidney, soothing liver, activating spleen and stomach, purging bowels, eliminating stubborn stool and releasing toxin |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1672714A (en) * | 2004-03-24 | 2005-09-28 | 伍锦成 | Gastrointestinal tea |
| CN1768788A (en) * | 2005-10-26 | 2006-05-10 | 广西灵峰药业有限公司 | Formulation for treating gastrointestinal disease and production method thereof |
| CN101444615A (en) * | 2008-11-24 | 2009-06-03 | 律北平 | Chinese traditional medical formula taken orally for curing acute enteritis |
| CN101816764A (en) * | 2010-05-06 | 2010-09-01 | 中山市新运来医药科技开发有限公司 | Chinese medicament granule preparation for warming kidney, soothing liver, activating spleen and stomach, purging bowels, eliminating stubborn stool and releasing toxin |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055783A (en) * | 2015-08-28 | 2015-11-18 | 广州国宇医药科技有限公司 | Traditional Chinese medicine composition for improving gastrointestinal functions |
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Application publication date: 20130123 |