CN100391510C - Chinese-medicinal preparation for gastroin testinal function and its making method - Google Patents
Chinese-medicinal preparation for gastroin testinal function and its making method Download PDFInfo
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- CN100391510C CN100391510C CNB2006100360182A CN200610036018A CN100391510C CN 100391510 C CN100391510 C CN 100391510C CN B2006100360182 A CNB2006100360182 A CN B2006100360182A CN 200610036018 A CN200610036018 A CN 200610036018A CN 100391510 C CN100391510 C CN 100391510C
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Abstract
A Chinese medicine for improving gastrointestinal function and treating gastrointestinal function disorder is prepared from 6 Chinese-medicinal materials including yam, cyperus tuber, gynostemma pentaphyllum, hemp seed, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that improves gastrointestinal function and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Gastrointestinal tract is the main position of nutritional labeling in the absorption of human body food.Dewater in the food, outside small-molecule substances such as inorganic salt, vitamin can directly absorb by human body, other macromole nutrient substance, as: protein, saccharide, fat etc. all need take place could to be absorbed by gastrointestinal mucosal after series reaction is decomposed into small-molecule substance in digestive tract, by human body is utilized.
Stomach is the part of expanding most in the digestive tract, plays the effect of temporary storage food.The acid digestion liquid that gastric is secreted can absorb by facilitating digestion.Gastric juice mainly comprises hydrochloric acid, pepsin and mucus etc.The sour environment that hydrochloric acid caused pepsin is normally played a role, but gastric acid is too high, and the harmonization of the stomach duodenal mucosa is had stimulation, causes Peptic Ulcers.
Small intestinal is to digest and assimilate most important position in the digestive tract.Excretory pancreatic juice, bile and intestinal fluid be to being digested by the propulsive food of stomach again in the small intestinal, and main nutrient matter is also in this absorption.The excretory intestinal fluid of the enteraden of mucous membrane of small intestine contains multiple digestive enzyme, and these enzymes match with digestive enzyme in the bile, sugar, fat, proteopepsis is become the material that can be absorbed by intestinal wall.
Large intestine is mainly postdigestive residual substance the temporary storage place is provided.If but feces overstays at big enteral, water is become stiff by the large intestine hyperabsorption, will produce constipation.
Gastrointestinal function is is normally then digested and assimilated normally, nutritional sufficiency, and function of human body is normal.If gastrointestinal dysfunction will cause a series of diseases, as dyspepsia, abdominal distention, diarrhoea, constipation etc., make nutrient substance lack, thereby cause other disease.So whether gastrointestinal function is the key of health normally.
The basic principle of control gastrointestinal dysfunction is to be careful in one's diet and daily hygiene and clinical treatment.At present, the method for clinical treatment mainly contains four aspects: (1) promotes gastrointestinal peristalsis, and facilitating digestion absorbs; (2) create the growing environment that is beneficial to profitable strain in the intestinal, improve alteration of intestinal flora; (3) loosening bowel to relieve constipation improves constipation; (4) protection coat of the stomach prevents or reduces the erosion of gastric acid to ulcer.
The present invention is the Chinese medicine that improves action of enterogastric function that has that screening obtains from Chinese medicine, can reach the enhancing digestive tract power, facilitating digestion absorbs, regulate gastric acid, loosening bowel to relieve constipation improves the effect of constipation, compare with Western medicine, it is little to have toxic and side effects, and the advantage that is suitable for taking for a long time is suitable for the crowd of gastrointestinal dysfunction.
Chinese invention patent publication number CN1302564A discloses " a kind of preparation method of improving health food and this health food of gastrointestinal function and beauty treatment ", to adopt Radix Angelicae Sinensis, Radix Paeoniae Rubra, Poria, Flos Carthami, Aloe, vitamin E, vitamin B2 be raw material through pulverize, sieve, prepared such as mixing, fill capsule, though to improving gastrointestinal function and beauty treatment has certain effect, but encapsulated with crude drug, gastrointestinal there is certain stimulation.Chinese invention patent publication number CN1125106A discloses " chang ' an capsule and its production and use ", selecting Adeps Bovis seu Bubali for use is primary raw material, adopt steam distillation to extract volatile oil and concentrated solution, make extractum, origanum volatile oil, extractum, absorb oil and be mixed in proportion, pulverize, granulate, encapsulated, though this invention can be antibiotic, antiinflammatory, analgesic, ease pain, improve effect such as gastrointestinal function, but the shortage of medicine source is unsuitable for large-scale production.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation, under Chinese medical theory instructed, by the rational proportion of each medical material, synergism improved gastrointestinal function, and the disease that gastrointestinal dysfunction is caused has excellent prevention and therapeutic effect.
Another one purpose of the present invention provides the preparation method of this Chinese medicine preparation.
The traditional Chinese medical science thinks that the major physiological function of stomach is received and digesting food and main logical falling; The major physiological function of small intestinal is reservoir and transformation and separates the useful from the waste; The major physiological function of large intestine is a transporting waste.Water paddy inlet is contained in stomach through esophagus, and water paddy is become thoroughly decomposed through stomach, pass in small intestinal down, and the food separating clear and excreting turbid of small intestinal to tentatively digesting through stomach, clear person, promptly the elite material is failed on spleen in lung, with the nutrition whole body; Turbid person, i.e. food residue waste matter, following defeated large intestine forms feces.So gastrointestinal function normally is the key that can water paddy the nutrition whole body.Symptoms such as belch, vomiting, abdominal distention, diarrhoea, dysentery or constipation will appear as gastrointestinal dysfunction.Spleen and stomach be the exterior and the interior mutually, the heart and the small intestine share a paired relationship, and the lung and the large intestine being interior-exteriorly related is so whether also dirty closely related with spleen, lung, the heart three gastrointestinal function is normally.So when treatment will also will to nurse one's health spleen, lung, the heart three simultaneously dirty paying attention to gastrointestinal.
The Chinese medicine preparation that improves gastrointestinal function of the present invention selects Rhizoma Dioscoreae, Herb Gynostemmae Pentaphylli, Rhizoma Cyperi, Massa Medicata Fermentata, Herba Plantaginis and Fructus Cannabis to carry out the combined preparation active component; Wherein, Rhizoma Dioscoreae is sweet flat, returns spleen lung kidney channel, supplementing QI and nourishing YIN, spleen reinforcing lung kidney.Herb Gynostemmae Pentaphylli is bitter sweet cold, returns the spleen lung meridian, invigorating the spleen and replenishing QI, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.The shared effect that plays spleen reinforcing lung QI invigorating of two medicines, gas helps the propelling of water paddy.The hot flat little hardship of Rhizoma Cyperi is little sweet, returns liver, tri-jiao channel, depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving.Massa Medicata Fermentata Gan Xinwen returns the taste warp, and stomach function regulating helps digestion.Herba Plantaginis is sweet cold, returns kidney liver lung meridian, inducing diuresis for treating stranguria syndrome, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat from the lung and dissipating phlegm.Fructus Cannabis is sweet flat, returns spleen, large intestine channel, loosening bowel to relieve constipation.Above-mentioned all medicines share, and reach invigorating the spleen and replenishing QI, lung moistening, and the effect of intestine moistening at above-mentioned gastrointestinal dysfunction, is played the purpose of improving gastrointestinal function.
The raw material consumption of preparation medicine activity component of the present invention is (weight portion): Rhizoma Dioscoreae 10-20 part, Herb Gynostemmae Pentaphylli 10-20 part, Rhizoma Cyperi 5-10 part, Massa Medicata Fermentata 10-30 part, Herba Plantaginis 10-20 part and Fructus Cannabis 5-15 part.Be preferably 10 parts of 15 parts of Rhizoma Dioscoreaes, 15 parts of Herb Gynostemmae Pentaphylli, 7.5 parts of Rhizoma Cyperis, 20 parts of Massa Medicata Fermentata, 15 parts of Herba Plantaginiss and Fructus Cannabiss.
Medicine of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into conventional oral formulations.
With Rhizoma Dioscoreae, Herb Gynostemmae Pentaphylli, Rhizoma Cyperi, Massa Medicata Fermentata, Herba Plantaginis, Fructus Cannabis mixes according to above-mentioned weight ratio, adding 8-10 times of water gaging soaked 2-4 hour, heating decocted 1.5 hours, filtered, and medicinal residues add 6-8 times of water gaging heating again and decocted 1 hour, filter, merge filtrate twice, left standstill 1 hour, pour out supernatant, supernatant is concentrated into relative density 1.08-1.12 in Rotary Evaporators,, advance spray dryer, 130-150 ℃ of inlet temperature control at preferred 1.1 o'clock, preferred 140 ℃, leaving air temp 100-120 ℃, preferred 110 ℃, 40-60 rev/min of nebulizer rotating speed, preferred 50 rev/mins, charging rate is 4-6ml/ minute, preferred 5ml/ minute, gets spray drying powder, pulverize, can get fine powder after sieving.The various conventional adjuvant of needs when this fine powder can add the preparation different dosage form, as: lubricant, binding agent etc. are prepared into the common Chinese medicine preparation formulation with conventional method of Chinese medicinal, as tablet, oral liquid, capsule, electuary etc.
The invention will be further elaborated below in conjunction with embodiment
Embodiment 1 capsule preparation of the present invention (is example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
150 parts of Rhizoma Dioscoreaes, 150 parts of Herb Gynostemmae Pentaphylli, 75 parts of Rhizoma Cyperis, 200 parts of Massa Medicata Fermentata, 150 parts of Herba Plantaginiss, 100 parts of Fructus Cannabiss are standby;
2. the Rhizoma Dioscoreae of above-mentioned weight proportion, Herb Gynostemmae Pentaphylli, Rhizoma Cyperi, Massa Medicata Fermentata, Herba Plantaginis, Fructus Cannabis add 9 times of water gagings immersions 3 hours, and heating decocted 1.5 hours, filtered, medicinal residues add 7 times of water gaging heating again and decocted 1 hour, filter, and merge filtrate twice, left standstill 1 hour, and poured out supernatant;
3. to be concentrated into relative density in Rotary Evaporators be 1.1 o'clock to supernatant, advances spray dryer, 140 ℃ of inlet temperature controls, 110 ℃ of leaving air temps, 50 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, spray drying powder;
4. adding adjuvant, mixing, the snap fit capsule of packing into.
Embodiment 2 preparation tablets of the present invention (is example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
150 parts of Rhizoma Dioscoreaes, 150 parts of Herb Gynostemmae Pentaphylli, 75 parts of Rhizoma Cyperis, 200 parts of Massa Medicata Fermentata, 150 parts of Herba Plantaginiss, 100 parts of Fructus Cannabiss are standby;
2. the Rhizoma Dioscoreae of above-mentioned weight proportion, Herb Gynostemmae Pentaphylli, Rhizoma Cyperi, Massa Medicata Fermentata, Herba Plantaginis, Fructus Cannabis add 9 times of water gagings immersions 3 hours, and heating decocted 1.5 hours, filtered, medicinal residues add 7 times of water gaging heating again and decocted 1 hour, filter, and merge filtrate twice, left standstill 1 hour, and poured out supernatant;
3. to be concentrated into relative density in Rotary Evaporators be 1.1 o'clock to supernatant, advances spray dryer, 140 ℃ of inlet temperature controls, 110 ℃ of leaving air temps, 50 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, spray drying powder;
4. pulverize spray drying powder and become fine powder, add adjuvant and make granule, drying, tabletting.
The Ergonomy evaluation experimental of experimental example 1 Chinese medicine preparation of the present invention
1. to 40 the healthy Kunming mouses that influence of mouse small intestine charcoal end propelling rate, a cleaning level animal, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups, i.e. matched group (irritate stomach give Insta-Char), high, medium and low 3 the dosage groups of above-mentioned Chinese medicine decocting liquid, 10 every group.
The Chinese medicine of the embodiment of the invention 1 adopts conventional decocting method preparation, and the simmer down to respective concentration, medication group gastric infusion, and decocting liquid various dose group comprises high dose group (12g/kg), middle dosage group (6g/kg), low dose group (3g/kg).
Thorough fasting 12h can't help water before each mouse experiment.Each mice is by different group gastric infusions during experiment, all irritate stomach behind the 1h and give 5% Insta-Char (arabic gum preparation) 0.1ml/10g body weight with 10%, put to death animal behind the 20min, cut open the belly and carefully take out small intestinal, tractive is not tiled on the flat board, and the length of measuring from the pylorus to the caecum is the small intestinal length overall, measures the front end to the reach of charcoal end from pylorus again, calculate the percentage rate that its length accounts for the small intestinal length overall, promptly the charcoal end advances percentage rate.The charcoal end advances percentage rate=charcoal end advance distance/small intestinal length overall.Result's T inspection statistics.See Table 1.
2. to 40 the healthy Kunming mouses that influence in mice gastric emptying time, a cleaning level animal, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups at random, i.e. matched group, high, medium and low 3 the dosage groups of above-mentioned Chinese medicine decocting liquid, 10 every group.
The Chinese medicine of the embodiment of the invention 1 adopts conventional decocting method preparation, and the simmer down to respective concentration, medication group gastric infusion, and decocting liquid various dose group comprises high dose group (12g/kg), middle dosage group (6g/kg), low dose group (3g/kg).
Each group of experiment proxima luce (prox. luc) is by thorough fasting 24h behind the corresponding group mediating recipe amount gastric infusion, and after 2h was administered once again before the experiment, every mouse stomach was given 0.1% methyl orange aqueous solution 0.2ml.Put to death animal behind the 20min, win stomach, place beaker, add the 10ml distilled water, stomach is cut off along greater gastric curvature, content is fully washed in the distilled water, use Na
2HCO
3Regulate Ph value 6.0～6.5, get supernatant after centrifugal, with 741 type ultraviolet-visible photometers under wavelength 420nm, add the 10ml distilled water with 0.1% methyl orange 0.2ml and make radix, respectively organize methyl orange trap in the mice stomach, and calculate by following formula and respectively to organize in the mice stomach average methyl orange residual rate.Methyl orange trap A/ methyl orange trap radix * 100% in methyl orange residual rate=stomach.The result carries out statistical procedures, sees Table 1.
The Chinese medicine of table 1 embodiment of the invention 1 to mouse small intestine charcoal end propelling rate and the influence in gastric emptying time (x ± s, n=10)
*Compare P＜0.05 with matched group
Methyl orange residual rate in the mouse small intestine charcoal end propelling rate stomach function regulating is influenced obviously by the reagent thing, high dose group and matched group relatively have significant difference P＜0.05.The propelling that is subjected to the reagent thing can promote charcoal end in the small intestinal is described, reduces the residual rate of methyl orange in the stomach.Prompting is subjected to the reagent thing can promote the motion of small intestinal and the wriggling of promotion stomach.
3. to 50 the healthy SD rats that influence of rat gastric acid, pepsinia, cleaning level animal, male female half and half, body weight 180 ± 220 grams, be divided into 5 groups at random, 10 every group of promptly blank groups, positive controls (histamine phosphate 4mg/kg body weight), high, medium and low 3 the dosage groups of above-mentioned Chinese medicine decocting liquid.
The Chinese medicine of the embodiment of the invention 1 adopts conventional decocting method preparation, and the simmer down to respective concentration, medication group gastric infusion, and decocting liquid various dose group comprises high dose group (12g/kg), middle dosage group (9g/kg), low dose group (6g/kg).
Irritate stomach and be subjected to the reagent thing after 2 days, fasting 24h freely drinks water, and 2h prohibits water before the art.The shallow fiber crops of ether, the surgical ligation pylorus, and in duodenum, tried thing 1 time, sew up wound.6h puts to death animal after the ligation, collects gastric juice, surveys the gastric juice amount, and centrifugal (2000r/min) 15min adopts the acid base neutralization titration method to measure free acid total acid and Anson-Mirshy method improved method pepsin activity respectively.The result carries out statistical procedures, sees Table 2.
The Chinese medicine of table 2 embodiment of the invention 1 to the influence of rat gastric acid, pepsinia (x ± s, n=10)
*Compare P＜0.05 with the blank group
*Compare P＜0.01 with the blank group
Be subjected to the reagent thing that mice gastric juice and pepsin are had in various degree influence, be subjected to the reagent thing that mice gastric juice amount is reduced, wherein middle and high dosage effect is (P＜0.05 comparatively significantly, 0.01), be subjected to the reagent thing can increase gastric acidity and pepsin activity, wherein effect of high dosage remarkable (P＜0.05).Prompting is subjected to reagent can reduce the secretion of gastric juice, but can increase gastric acidity stomach function regulating protease activities.
Claims (5)
1. Chinese medicine preparation that improves gastrointestinal function, the active component that it is characterized in that it is to be made by the raw material of following weight portion: Rhizoma Dioscoreae 10-20 part, Herb Gynostemmae Pentaphylli 10-20 part, Rhizoma Cyperi 5-10 part, Massa Medicata Fermentata 10-30 part, Herba Plantaginis 10-20 part and Fructus Cannabis 5-15 part.
2. want 1 Chinese medicine preparation according to right, wherein make the active component raw material consumption and be: 10 parts of 15 parts of Rhizoma Dioscoreaes, 15 parts of Herb Gynostemmae Pentaphylli, 7.5 parts of Rhizoma Cyperis, 20 parts of Massa Medicata Fermentata, 15 parts of Herba Plantaginiss and Fructus Cannabiss.
3. the preparation method of Chinese medicine preparation according to claim 1 and 2 comprises the steps:
1) it is standby to take by weighing each crude drug Rhizoma Dioscoreae, Herb Gynostemmae Pentaphylli, Rhizoma Cyperi, Massa Medicata Fermentata, Herba Plantaginis, Fructus Cannabis;
2) Rhizoma Dioscoreae, Herb Gynostemmae Pentaphylli, Rhizoma Cyperi, Massa Medicata Fermentata, Herba Plantaginis, the Fructus Cannabis by above-mentioned weight proportion mixes according to above-mentioned weight ratio, adding 8-10 times of water gaging soaked 2-4 hour, heating decocted 1.5 hours, filter, medicinal residues add 6-8 times of water gaging heating again and decocted 1 hour, filter, and merge filtrate twice, left standstill 1 hour, and poured out supernatant;
3) supernatant is concentrated into relative density 1.08-1.12 in Rotary Evaporators, advances spray dryer, 130-150 ℃ of inlet temperature control, and leaving air temp 100-120 ℃, 40-60 rev/min of nebulizer rotating speed, charging rate is 4-6ml/ minute, gets spray drying powder;
4) pulverize, can get fine powder after sieving as active component.
4. preparation method according to claim 3, it also comprises active component and the additive of tablet mixed pressuring plate that step 4) is got.
5. preparation method according to claim 3, it comprises that also the active component that step 4) is got mixes with the capsule adjuvant, and is encapsulated.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100360182A CN100391510C (en) | 2006-06-20 | 2006-06-20 | Chinese-medicinal preparation for gastroin testinal function and its making method |
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| CNB2006100360182A CN100391510C (en) | 2006-06-20 | 2006-06-20 | Chinese-medicinal preparation for gastroin testinal function and its making method |
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| CN100391510C true CN100391510C (en) | 2008-06-04 |
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| CNB2006100360182A Expired - Fee Related CN100391510C (en) | 2006-06-20 | 2006-06-20 | Chinese-medicinal preparation for gastroin testinal function and its making method |
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| CN103734725B (en) * | 2013-12-31 | 2015-09-23 | 陈慧婷 | A kind of Chinese yam Asiatic plantain dispersing tablet and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207267A (en) * | 1998-05-29 | 1999-02-10 | 李胤良 | Health beverage capable of strengthening spleen and stomach |
| CN1546066A (en) * | 2003-09-15 | 2004-11-17 | 史 忠 | Gastrointestinal ulcer treating Chinese traditional medicine |
| CN1615944A (en) * | 2004-09-07 | 2005-05-18 | 马占风 | Chinese medicine recipe for treating gastric disease |
-
2006
- 2006-06-20 CN CNB2006100360182A patent/CN100391510C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207267A (en) * | 1998-05-29 | 1999-02-10 | 李胤良 | Health beverage capable of strengthening spleen and stomach |
| CN1546066A (en) * | 2003-09-15 | 2004-11-17 | 史 忠 | Gastrointestinal ulcer treating Chinese traditional medicine |
| CN1615944A (en) * | 2004-09-07 | 2005-05-18 | 马占风 | Chinese medicine recipe for treating gastric disease |
Non-Patent Citations (4)
| Title |
|---|
| 中医治疗慢性萎缩性胃炎临床近况. 黄蓝洋.实用中医内科杂志，第19卷第3期. 2005 |
| 中医治疗慢性萎缩性胃炎临床近况. 黄蓝洋.实用中医内科杂志，第19卷第3期. 2005 * |
| 调胃舒肝汤治疗功能性消化不良108例疗效观察. 柯启贤等.新中医，第36卷第3期. 2004 |
| 调胃舒肝汤治疗功能性消化不良108例疗效观察. 柯启贤等.新中医，第36卷第3期. 2004 * |
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