CN102743442B - Traditional Chinese medicine composition for improving gastrointestinal function and preparation method thereof - Google Patents
Traditional Chinese medicine composition for improving gastrointestinal function and preparation method thereof Download PDFInfo
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- CN102743442B CN102743442B CN201210265770XA CN201210265770A CN102743442B CN 102743442 B CN102743442 B CN 102743442B CN 201210265770X A CN201210265770X A CN 201210265770XA CN 201210265770 A CN201210265770 A CN 201210265770A CN 102743442 B CN102743442 B CN 102743442B
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Abstract
The invention discloses a traditional Chinese medicine composition for improving gastrointestinal function and a preparation method of the traditional Chinese medicine composition, belonging to the field of traditional Chinese medicine. Traditional Chinese medicines of Colysis wrightii, nanmu skin, Aralia chinensis leaf, jasminum lanceolarium and long-stalked kadsura serving as raw materials are combined to prepare active ingredients, and oral liquid is prepared by the active ingredients and normal medicinal pharmaceutical adjuvants. The traditional Chinese medicine composition is capable of improving gastrointestinal function and effective in treating gastrointestinal dysfunction.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that improves gastrointestinal function, belong to the field of Chinese medicines.
Background technology
Gastrointestinal tract is one of digestion significant points, the digestion of human body dietary intake and the main position of absorption of nutrient ingredients; Stomach is the part of expanding most in the digestive tract, plays the effect of temporary storage food; Small intestinal is to digest and assimilate most important position in the digestive tract, and the pancreatic juice of secreting in the small intestinal, bile and intestinal fluid digest the food that is advanced by stomach again, and main nutrient matter is also in this absorption.
Dewater in the human pickuping food, outside small-molecule substances such as inorganic salt, vitamin can directly absorb by human body, other macromole nutrient substance such as protein, sugar, fat etc. all need to take place in digestive tract could to be absorbed by gastrointestinal mucosal after series reaction is decomposed into small-molecule substance; The acid digestion liquid that gastric is secreted can absorb by facilitating digestion, and gastric juice mainly comprises hydrochloric acid, pepsin and mucus etc., the sour environment that hydrochloric acid causes pepsin is normally played a role, but gastric acid is too high, the harmonization of the stomach duodenal mucosa there is stimulation, causes Peptic Ulcers; The intestinal fluid of the enteraden of mucous membrane of small intestine secretion contains multiple digestive enzyme, and these enzymes match with digestive enzyme in the bile, the material that can be absorbed sugar, fatty, proteopepsis one-tenth by intestinal wall; Large intestine is mainly postdigestive residual substance the temporary storage place is provided.
Behind the human pickuping food, if gastrointestinal function normally digest and assimilate normal, nutritional sufficiency; If gastrointestinal dysfunction will cause a series of diseases, as dyspepsia, abdominal distention, diarrhoea, constipation etc., thereby nutrient substance lacks the disease that causes other; So whether gastrointestinal function is one of key factor of health normally.
Chinese invention patent publication number CN1302564A discloses " a kind of preparation method of improving health food and this health food of gastrointestinal function and beauty treatment ", adopts Radix Angelicae Sinensis, Radix Paeoniae Rubra, Poria, Flos Carthami, Aloe, vitamin E, vitamin B
2For raw material through pulverize, sieve, prepared such as mixing, fill capsule, though have certain effect to improving gastrointestinal function and beauty treatment, encapsulated with crude drug, gastrointestinal is had certain stimulation.Chinese invention patent publication number CN101450074 discloses " a kind of obvious gastrointestinal function, anti-compositions that treats constipation improved ", adopt oligomeric xylose, biological calcium carbonate, vitamin C, milk flavour preparation, this forms non-Chinese crude drug composition combination, and effect mainly embodies the defecating feces excretion that improves gastrointestinal function.Chinese invention patent publication number CN102362970A discloses " a kind of Chinese medicine composition and preparation technology thereof who improves gastrointestinal function ", and adopting Aloe, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Aurantii is feedstock production, is primarily aimed at the not normal constipation symptom of gastrointestinal function.
The present invention is the Chinese medicine composition that improves action of enterogastric function that has that screening obtains from Chinese crude drug, can reach the enhancing digestive tract power, and facilitating digestion absorbs, the effect of loosening bowel to relieve constipation; Compare with Western medicine, it is little to have toxic and side effects, and the advantage that is suitable for taking for a long time is suitable for the crowd of gastrointestinal dysfunction.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition, under Chinese medical theory instructed, by the rational proportion of each medical material, synergism improved gastrointestinal function, and the disease that gastrointestinal dysfunction is caused has excellent prevention and therapeutic effect.
Another one purpose of the present invention provides the preparation method of this Chinese medicine composition.
The traditional Chinese medical science thinks that the major function of stomach is received and digesting food, main logical falling; The major function of small intestinal is reservoir and transformation, separates the useful from the waste; The major function of large intestine is transporting waste.Symptoms such as belch, vomiting, abdominal distention, diarrhoea, dysentery or constipation will appear as gastrointestinal dysfunction.Spleen and stomach phase the exterior and the interior, the heart and the small intestine share a paired relationship, the lung and the large intestine being interior-exteriorly related is so whether also dirty closely related with spleen, lung, the heart three gastrointestinal function is normally.
The Chinese medicine composition that improves gastrointestinal function of the present invention, selecting Colysis wrightii, Cortex nanmu, Folium araliae chinensis, Radix seu Caulis Jasmini lanceolarii, Herba Schisandrae intermediae is raw material; Cortex nanmu wherein, bitter, hot, warm, play warming the stomach and in, the sending down the abnormal ascending QI effect; Folium araliae chinensis, sweet, little hardship, flat plays inducing diuresis to remove edema, the effect of detoxifcation dysentery relieving; Radix seu Caulis Jasmini lanceolarii, sweet, cold, play expelling wind and removing dampness, the clearing away heat to alleviate pain effect; Herba Schisandrae intermediae, little hardship, cold plays heat-clearing and toxic substances removing, promoting blood circulation and stopping pain effect; Colysis wrightii, sweet, flat, play the dissipating blood stasis anastalsis.Above-mentioned all medicines share, and reach that heat clearing away is regulated the flow of vital energy and the effect of stomach and alleviating pain, at gastrointestinal dysfunction, play and improve the gastrointestinal function purpose.
The raw material consumption of preparation medicine activity component of the present invention is: Colysis wrightii 5-30 part, Cortex nanmu 5-30 Fen, Folium araliae chinensis 5-30 part, Radix seu Caulis Jasmini lanceolarii 5-30 part, Herba Schisandrae intermediae 5-30 part.Be preferably 15 parts of Colysis wrightii, Cortex nanmu 15 12 parts of Fen, Folium araliae chinensis, 12 parts of Radix seu Caulis Jasmini lanceolariis, 12 parts of Herba Schisandrae intermediaes.
Chinese medicine composition of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into conventional oral formulations.
With 15 parts of Colysis wrightii, 12 parts of 15 parts of Folium araliae chinensis of Cortex nanmu, 12 parts of Radix seu Caulis Jasmini lanceolariis, 12 parts of Herba Schisandrae intermediaes, mix according to above-mentioned weight ratio, add 8-10 times of water gaging and soaked 2-4 hour, heating decocted 1.5 hours, filtered, medicinal residues add 6-8 times of water gaging heating again and decocted 1 hour, filter, merge filtrate twice, left standstill 1 hour, pour out supernatant, supernatant concentration is to relative density 1.08-1.10, and preferred density is 1.09, advances spray dryer, 130-140 ℃ of inlet temperature control, preferred 135 ℃, leaving air temp 100-110 ℃, preferred 105 ℃, 40-50 rev/min of nebulizer rotating speed, preferred 45 rev/mins, charging rate is 3-5 ml/ minute, preferred 4ml/ minute, get spray drying powder, can get fine powder behind the crushing screening.
The various conventional adjuvant of needs when this fine powder can add the preparation different dosage form, as: lubricant, binding agent etc. are prepared into the common Chinese medicine preparation formulation with conventional method of Chinese medicinal, as tablet, oral liquid, capsule, electuary etc.
The invention will be further elaborated below in conjunction with embodiment
Embodiment 1 capsule preparation of the present invention (be example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
150 parts of Colysis wrightii, Cortex nanmu 150 120 parts of Fen, Folium araliae chinensis, 120 parts of Radix seu Caulis Jasmini lanceolariis, 120 parts of Herba Schisandrae intermediaes are standby;
2. the Colysis wrightii of above-mentioned weight proportion, Cortex nanmu, Folium araliae chinensis, Radix seu Caulis Jasmini lanceolarii, Herba Schisandrae intermediae add 10 times of water gagings immersions 4 hours, and heating decocted 1.5 hours, filtered, medicinal residues add 8 times of water gaging heating again and decocted 1 hour, filter, and merge filtrate twice, left standstill 1 hour, and poured out supernatant;
3. above-mentioned supernatant concentration to relative density is 1.1 o'clock, advances spray dryer, 140 ℃ of inlet temperature controls, and 110 ℃ of leaving air temps, 50 rev/mins of nebulizer rotating speeds, charging rate is 5 ml/ minutes, gets spray drying powder;
4. above-mentioned spray drying powder adds adjuvant, mixing, the snap fit capsule of packing into.
Embodiment 2 preparation tablets of the present invention (be example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
150 parts of Colysis wrightii, Cortex nanmu 150 120 parts of Fen, Folium araliae chinensis, 120 parts of Radix seu Caulis Jasmini lanceolariis, 120 parts of Herba Schisandrae intermediaes are standby;
2. the Colysis wrightii of above-mentioned weight proportion, Cortex nanmu, Folium araliae chinensis, Radix seu Caulis Jasmini lanceolarii, Herba Schisandrae intermediae add 8 times of water gagings immersions 2 hours, and heating decocted 1.5 hours, filtered, medicinal residues add 6 times of water gaging heating again and decocted 1 hour, filter, and merge filtrate twice, left standstill 1 hour, and poured out supernatant;
3. above-mentioned supernatant concentration to relative density is 1.08 o'clock, advances spray dryer, 130 ℃ of inlet temperature controls, and 100 ℃ of leaving air temps, 40 rev/mins of nebulizer rotating speeds, charging rate is 3 ml/ minutes, gets spray drying powder;
4. pulverize above-mentioned spray drying powder and become fine powder, add adjuvant and make granule, drying, tabletting.
The Ergonomy evaluation experimental of experimental example 1 Chinese medicine composition of the present invention
1. Chinese medicine composition of the present invention is to the influence of experiment mice small intestinal charcoal end propelling rate
60 of the healthy Kunming mouses of cleaning level, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups, namely irritates the matched group that stomach gives Insta-Char, high, medium and low three the dosage groups of above-mentioned traditional Chinese medicine composition water decocting liquid, 15 every group.
Get 15 parts of Colysis wrightii, Cortex nanmu 15 12 parts of Fen, Folium araliae chinensis, 12 parts of Radix seu Caulis Jasmini lanceolariis, 12 parts of Herba Schisandrae intermediaes, adopt conventional decocting method preparation, and simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (30g/kg), middle dosage group (15g/kg), low dose group (7.5g/kg).
Respectively organize the mice fasting before the experiment, press different group gastric infusions during experiment, all irritate stomach behind the 1h and give 5% Insta-Char (the arabic gum preparation with 10%) 0.1ml/10g body weight, put to death animal behind the 20min, cut open the belly and take out small intestinal, tractive is not tiled on the flat board, the length of measurement from the pylorus to the caecum is the small intestinal length overall, measure the front end to the reach of charcoal end from pylorus again, calculate the percentage rate that its length accounts for the small intestinal length overall, namely the charcoal end advances percentage rate.The charcoal end advances percentage rate=charcoal end advance distance/small intestinal length overall.The results are shown in Table 1.
Chinese medicine composition of the present invention is to the influence in mice gastric emptying time
60 of the healthy Kunming mouses of cleaning level, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups at random, i.e. matched group, high, medium and low three the dosage groups of above-mentioned traditional Chinese medicine composition water decocting liquid, 15 every group.
Get 15 parts of Colysis wrightii, Cortex nanmu 15 12 parts of Fen, Folium araliae chinensis, 12 parts of Radix seu Caulis Jasmini lanceolariis, 12 parts of Herba Schisandrae intermediaes, adopt conventional decocting method preparation, and simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (30g/kg), middle dosage group (15g/kg), low dose group (7.5g/kg).
Each group of experiment proxima luce (prox. luc) is by fasting 24h behind the corresponding group mediating recipe amount gastric infusion, and after 2h was administered once again before the experiment, every mouse stomach was given 0.1% methyl orange aqueous solution 0.2ml.Put to death animal behind the 20min, win stomach, place beaker, add the 10ml distilled water, stomach is cut off along greater gastric curvature, content is fully washed in the distilled water, use Na
2HCO
3Regulate Ph value 6.0 ~ 6.5, get supernatant after centrifugal, with 741 type ultraviolet-visible photometers under wavelength 420nm, add the 10ml distilled water with 0.1% methyl orange, 0.2 ml and make radix, respectively organize methyl orange trap in the mice stomach, and calculate by following formula and respectively to organize in the mice stomach average methyl orange residual rate.Methyl orange trap A/ methyl orange trap radix * 100% in methyl orange residual rate=stomach.The results are shown in Table 1.
Table 1 Chinese medicine composition of the present invention to mouse small intestine charcoal end propelling rate and the influence in gastric emptying time (
± s, n=15)
| Group | Number of animals | Dosage (g/kg) | Charcoal end propelling rate (%) | Methyl orange residual rate (%) in the stomach |
| Matched group | 15 | 0.0 | 35.71±3.95 | 43.95±3.26 |
| Low dose group | 15 | 7.5 | 43.28±4.17* | ?37.29±4.02* |
| Middle dosage group | 15 | 15.0 | 48.55±3.82* | ?32.33±5.21* |
| High dose group | 15 | 30.0 | 53.82±5.37* | ?29.51±4.58* |
* representative is compared with matched group
P＜0.05
Chinese medicine composition of the present invention is obvious to methyl orange residual rate influence in the mouse small intestine charcoal end propelling rate stomach function regulating, and high, medium and low three dosage groups and matched group relatively have significant difference
P＜0.05.Illustrate that this Chinese medicine composition can promote the propelling at charcoal end in the small intestinal, reduce the residual rate of methyl orange in the stomach, point out this Chinese medicine composition can promote intestinal motility and promotion gastric peristalsis.
Claims (5)
1. Chinese medicine composition that improves gastrointestinal function, the active component that it is characterized in that it is to be made by following bulk drugs: Colysis wrightii 5-30 part, Cortex nanmu 5-30 part, Folium araliae chinensis 5-30 part, Radix seu Caulis Jasmini lanceolarii 5-30 part, Herba Schisandrae intermediae 5-30 part.
2. according to the Chinese medicine composition of claim 1, wherein the consumption of each crude drug is: 15 parts of Colysis wrightii, Cortex nanmu 15 12 parts of Fen, Folium araliae chinensis, 12 parts of Radix seu Caulis Jasmini lanceolariis, 12 parts of Herba Schisandrae intermediaes.
3. the preparation method of Chinese medicine composition according to claim 1 and 2 comprises the steps:
1) it is standby to take by weighing each crude drug Colysis wrightii, Cortex nanmu, Folium araliae chinensis, Radix seu Caulis Jasmini lanceolarii, Herba Schisandrae intermediae; 2) Colysis wrightii, Cortex nanmu, Folium araliae chinensis, Radix seu Caulis Jasmini lanceolarii, the Herba Schisandrae intermediae by above-mentioned weight proportion mixes according to above-mentioned weight ratio, adding 8-10 times of water gaging soaked 2-4 hour, heating decocted 1.5 hours, filter, medicinal residues add 6-8 times of water gaging heating again and decocted 1 hour, filter, and merge filtrate twice, left standstill 1 hour, and poured out supernatant; 3) supernatant concentration is advanced spray dryer to relative density 1.08-1.10,130-140 ℃ of inlet temperature control, and leaving air temp 100-110 ℃, 40-50 rev/min of nebulizer rotating speed, charging rate is 3-5 ml/ minute, gets spray drying powder.
4. preparation method according to claim 3 is used active component and tablet that step 4) gets always the adjuvant mixed pressuring plate.
5. preparation method according to claim 3 is mixed the active component that step 4) gets with capsule adjuvant commonly used, and is encapsulated.
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| CN102885894A (en) * | 2012-11-07 | 2013-01-23 | 广州国宇医药科技有限公司 | Traditional Chinese medicinal composition for improving gastrointestinal function and method for preparing traditional Chinese medicinal composition |
| CN105055783A (en) * | 2015-08-28 | 2015-11-18 | 广州国宇医药科技有限公司 | Traditional Chinese medicine composition for improving gastrointestinal functions |
| CN107260901A (en) * | 2017-06-13 | 2017-10-20 | 孙梅华 | It is a kind of to improve the nursing Chinese medicine liquid of gastrointestinal function |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742852A (en) * | 2005-09-19 | 2006-03-08 | 蓝子花 | Medicated lanceolarium Roxb medicated liquor |
| CN1742800A (en) * | 2005-09-19 | 2006-03-08 | 蓝子花 | Wuxiangteng medicated liquor |
| CN100998788A (en) * | 2006-01-12 | 2007-07-18 | 广州王老吉药业股份有限公司 | Traditional Chinese medicine composition dripping for treating gastrointestinal disease and its preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742852A (en) * | 2005-09-19 | 2006-03-08 | 蓝子花 | Medicated lanceolarium Roxb medicated liquor |
| CN1742800A (en) * | 2005-09-19 | 2006-03-08 | 蓝子花 | Wuxiangteng medicated liquor |
| CN100998788A (en) * | 2006-01-12 | 2007-07-18 | 广州王老吉药业股份有限公司 | Traditional Chinese medicine composition dripping for treating gastrointestinal disease and its preparing method |
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