CN103621938B - Food, health-care product or medicinal composition for improving gastronintestinal digestion function - Google Patents
Food, health-care product or medicinal composition for improving gastronintestinal digestion function Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/152—Cereal germ products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a food, a health-care product or a medicinal composition for improving the gastronintestinal digestion function. The food, health-care product or medicinal composition is a preparation prepared from the following raw materials in parts by weight: 10-15 parts of yam, 10-15 parts of malt, and 3-5 parts of fennel. The invention also provides a preparation method and application of the food, the health-care product or the medicinal composition. After yam, malt and fennel are used in a combined manner, the food, the health-care product or the medicinal composition has a remarkable effect of improving the gastronintestinal digestion function, and a new choice of foods, health-care products or medicines is provided to clinical application.
Description
Technical field
The present invention relates to a kind of food, the health products or pharmaceutical composition and its production and use that improve digestive functions.
Background technology
Taste are reservoir of food and drink, the foundation of acquired constitution, source of generating QI and blood.If the spleen being blocked by dampness, transformation failure of spleen, clear QI failing to ascend, can affect stomach received with fall, occur food less, vomiting, feel sick, the disease such as abdominal fullness and distention.Otherwise, if intemperance of taking food, retention of food in the stomach, stomach Qi rising, often can affect the clear and transporting of the liter of spleen, occur that abdominal distension such as to be had loose bowels the disease.The traditional Chinese medical science has cloud: taste all kinds of diseases and ailments of lacking of proper care are raw.Namely digestive functions is unbalance is one of main manifestations of taste imbalance.
For the unbalance disease of gastro-intestinal digestion, current employing Chinese medicine effect is better, as conventional ageratum oral liquid, its main component is: patchouli oil, perilla leaf oil, the root of Dahurain angelica, rhizoma atractylodis, the bark of official magnolia (ginger system), the raw tuber of pinellia, Poria cocos, dried orange peel, the shell of areca nut, extract of licorice root, can be used for treatment abdominal distention, vomit diseases such as having loose bowels; Classical Jianpi Wan (" Standards of Diagnosis and Treatment ") is made up of the bighead atractylodes rhizome, the banksia rose, the coptis, Radix Glycyrrhizae, PORIA ALBA, ginseng, Divine Comedy, dried orange peel, fructus amomi, coloured malt, hawthorn, Chinese yam, nutmeg, and can be used for strengthening the spleen and stomach, help digestion antidiarrheal.
But at present in conventional prescription, flavour of a drug are more, certainly will bring higher treatment cost to patient.Therefore, research and develop a kind of flavour of a drug composition Traditional Chinese medicine composition few and evident in efficacy and seem particularly necessary.Yet there are no the report being used for Chinese yam, Fructus Hordei Germinatus, fennel seeds three taste medicine compatibility to improve digestion function of stomach and intestine.
Summary of the invention
The object of the present invention is to provide a kind of food, health products or the pharmaceutical composition that improve digestive functions.Another object of the present invention is to preparation method and purposes that this food, health products or pharmaceutical composition are provided.
The invention provides a kind of food, health products or the pharmaceutical composition that improve digestive functions, it is the preparation be prepared from by the raw material of following weight proportion: Chinese yam 10 ~ 15 parts, 10 ~ 15 parts, Fructus Hordei Germinatus, fennel seeds 3 ~ 5 parts.
Preferably, it is the preparation be prepared from by the raw material of following weight proportion: Chinese yam 15 parts, 10 parts, Fructus Hordei Germinatus, fennel seeds 3 parts.
Wherein, described preparation be by the medicinal powder of each bulk drug, the water of bulk drug or/and ethanol extract is active component, to add in pharmacy or health products the preparation that conventional auxiliary material or complementary composition are prepared from.
Further, described preparation is oral formulations.
Further, described oral formulations is paste, oral liquid, medicinal tea, granule, capsule, pill, tablet or powder.
Present invention also offers the preparation method of above-mentioned food, health products or pharmaceutical composition, it comprises the steps:
(1) each bulk drug is taken by weight ratio;
(2) each bulk drug directly pulverized or add water or/and after alcohol extract, adding auxiliary material conventional in pharmacy or health products or complementary composition, be prepared into conventional preparation, obtain final product.
Present invention also offers above-mentioned food, health products or pharmaceutical composition and prepare the purposes in food, health products or the medicine improving digestive functions.
Wherein, described food, health products or medicine have to promote intestinal motility, gastric secretion, improves the food of peptic activity of stomach, health products or medicine.
Food provided by the invention, health products or pharmaceutical composition are by promoting intestinal motility, promoting gastric secretion, improving the number of ways such as peptic activity of stomach, significantly improve digestive functions, clear efficacy is the clinical selection providing a kind of new medicine and health products.
Detailed description of the invention
The preparation of embodiment 1 food of the present invention, health products or medicine
Get Chinese yam 15g, Fructus Hordei Germinatus 10g, fennel seeds 3g, boiling extracts 3 times, decocts 0.5h at every turn, merges decocting liquid, after concentrated, add appropriate filler, prepares particle.
The preparation of embodiment 2 food of the present invention, health products or medicine
Get Chinese yam 10g, Fructus Hordei Germinatus 15g, fennel seeds 3g, add 75%v/v alcohol extract 2 times, alcohol extract is for subsequent use, and dregs of a decoction boiling extracts 2 times, and decocting liquid is for subsequent use; After alcohol extract is reclaimed ethanol, merge with decocting liquid, after concentrated, add appropriate filler, prepare particle, namely compressing tablet obtains tablet.
The preparation of embodiment 3 food of the present invention, health products or medicine
Get Chinese yam 13g, Fructus Hordei Germinatus 10g, fennel seeds 5g, 65%v/v alcohol extract 3 times, merge alcohol extract, spraying dry, adds appropriate filler, prepares capsule.
Beneficial effect of the present invention is proved below by way of concrete pharmacodynamic experiment
Test example 1 present composition promotes the investigation of digestive function
1 experiment material
1.1 this experiment of Experimental agents setting 3 kinds various dose proportioning groups carry out preliminary screening, are respectively proportioning group 1(Chinese yam: Fructus Hordei Germinatus: fennel seeds=5:3.33:1, i.e. Chinese yam 15g, Fructus Hordei Germinatus 10g, fennel seeds 3g); Proportioning group 2(Chinese yam: Fructus Hordei Germinatus: fennel seeds=3.33:5:1, i.e. Chinese yam 10g, Fructus Hordei Germinatus 15g, fennel seeds 3g); Proportioning group 3(Chinese yam: Fructus Hordei Germinatus: fennel seeds=2.6:2:1, i.e. Chinese yam 13g, Fructus Hordei Germinatus 10g, fennel seeds 5g).Water boiling and extraction in above-mentioned prescription, concentrate to obtain thick paste, being mixed with concentration is that 47g crude drug in whole/100ml medicinal extract sample is for subsequent use.
Ageratum oral liquid (Taiji Group Chongqing Fuling Pharmaceutical Factory Co., Ltd., lot number: 13060281)
1.2 animal used as test KM mouse, Da Shuo bio tech ltd, Chengdu provides, and body weight 18-22g is male, the animal quality certification number: animal credit number: SCXK(river) 2008-24; SD rat, Chengdu University of Traditional Chinese Medicine's Experimental Animal Center provides, body weight 140g ~ 160g, male, the animal quality certification number: SCXK(river) 2008-11
1.3 experiment reagents and electronics balance (thousand-island forest park, 0.1g); Loperamide hydrochloride (Xi'an Yang Sen company, lot number: 031014878); Gum arabic, prepared Chinese ink.
2 experimental techniques
2.1 impacts on intestinal motility
Male KM mouse 72, comprises 3 kinds of different ratio administration groups, blank group, ageratum oral liquid group and model control group, every treated animal 12 by random point 6 groups.Give 3 kinds of different ratio given the test agent with 10 of human body consumption per day times of (4.7g crude drug/kgBW) per os, ageratum oral liquid 3.3ml/kgBW(is grown up consumption 10 times), 1 time/d, continuous 15d, blank group and model control group give experimental water by same volume.After given the test agent 15d, water 16h is can't help in the fasting of each group mouse.After 30min, model control group and 4 administration group gavages give compound diphenoxylate (5mg/kgBW), and blank group to experimental water.After compound diphenoxylate 30min, 4 administration groups give the prepared Chinese ink (activated carbon powder containing 5%, 10% gum arabic) containing corresponding given the test agent, and blank group and model control group give prepared Chinese ink.After giving prepared Chinese ink 25min, disconnected neck puts to death animal, anatomical isolation mesenterium, take out pylorus (upper end) to ileocecus (lower end) little intestinal tube, be placed in pallet, intestinal tube is gently drawn to be in line, measure total small intestinal length, prepared Chinese ink advances length (pylorus is to prepared Chinese ink forward position), is calculated as follows prepared Chinese ink impelling ratio (P) and ink progradation:
Prepared Chinese ink impelling ratio (P)=prepared Chinese ink advances length (cm)/total small intestinal length (cm)
Ink progradation
SPSS12.0 software is adopted to carry out statistical analysis to each proportioning group result and blank group, model control group.
2.2 impacts on digestive enzyme activity
Male SD rat 50, random point 5 groups, comprise 3 kinds of different ratio administration groups, blank group, ageratum oral liquid groups, every treated animal 10, the difference of the weight of animals should be no more than 10% of average weight.With 10 of human body consumption per day times (4.7g crude drug/kgBW), per os gives 3 kinds of different ratio given the test agent, and ageratum oral liquid 3.3ml/kgBW(is grown up consumption 10 times), 1 time/d, continuous 30d, blank group gives experimental water by same volume.After last administration, water 24h is can't help in each treated animal fasting, adopts etherization rat pylorus ligature law to collect the gastric juice of discharging in certain hour, gastric juice amount in the analytical unit time.Get the conical flask that gastric juice 1mL puts into 50mL, add 0.05mol/L hydrochloric acid solution 15mL to shake up, the protein pipe putting into made fresh (selects internal diameter 1.5mm glass tube, injection Fresh Egg is clear, put hot bath keeps flat make protein coagulating after take out, discard alveolate protein pipe, put Refrigerator store, make 3cm length before use) two pieces.Be stoppered bottleneck, in 37 DEG C of insulating boxs, hatch 24h, take out protein pipe, measure the length (mm) of protein pipe two ends transparent part with chi, ask its mean value with the value of four ends.Calculate pepsin activity and pepsin discharge rate.
Pepsin activity unit (U/mL)=tetra-end protein pipe transparent part length average
2× 16
Pepsin discharge rate (U/h)=pepsin activity × gastric juice amount per hour
SPSS12.0 software is adopted to carry out statistical analysis to each proportioning group result and blank group, model control group.
3 experimental results
Different prescription proportioning to the experimental result of mouse small intestine motion effects in table 1:
The different prescription proportioning of table 1 is on the impact of mouse ink progradation
Note: compare with model control group, * P<0.05, * * P<0.01; Compare with proportioning group 1,
△p < 0.05,
△ △p < 0.01.
From table 1, model control group prepared Chinese ink impelling ratio and propelling rate all remarkable in blank group (P<0.05), show that Constipated mice is set up.Compared with model control group, medicine of the present invention/health food different ratio group, ageratum oral liquid all can significantly promote intestinal motility (P<0.05, P<0.01), wherein the ink progradation of proportioning group 1 pair of mouse has pole significant difference.The ink progradation of compatibility group 1 pair of mouse is significantly better than compatibility group 3 and compatibility group 4(P<0.05), act on more obvious.
Different prescription proportioning to the sex experimental result of rat digestive enzyme in table 2:
The different prescription proportioning of table 2 is on the impact of rat digestive ferment
Note: compare with blank group, * P<0.05, * * P<0.01; Compare with proportioning group 1,
△p < 0.05,
△ △p < 0.01.
From table 2, compared with blank group, the rat stomach protease discharge rate of medicine of the present invention/health food different ratio group, ageratum oral liquid all has significant difference (P<0.05, P<0.01), and proportioning group 1 pole conspicuousness effect (P<0.01), rat stomach prolease activity can be significantly improved, promote that rat gastric secretion increases (P<0.05).Compatibility group 1 improves rat stomach prolease activity, promotes that the effect that rat gastric secretion increases significantly is better than other each compatibility groups (P<0.05).
To sum up, medicine of the present invention/health food different ratio group all has and promotes intestinal motility significantly, promotes the effect such as pepsinia, wherein especially with proportioning group 1(Chinese yam: Fructus Hordei Germinatus: fennel seeds=5:3.33:1, i.e. Chinese yam 15g, Fructus Hordei Germinatus 10g, fennel seeds 3g) effect the most remarkable, by promoting mouse small intestine motion, promote rat gastric secretion, improving the number of ways such as peptic activity of stomach and improve digestive functions, is the optimum dose proportion of medicine/health food of the present invention.
Test example 2 pharmaceutical composition/health food of the present invention improves gastrointestinal function effect and is better than simple
Checking:
1 experiment material
1.1 Experimental agents pharmaceutical composition/health food of the present invention, by Chinese yam 15g, Fructus Hordei Germinatus 10g, fennel seeds 3g(consumption per day) etc. form for primary raw material.Water boiling and extraction, concentrating and being mixed with concentration is that 47g crude drug in whole/100ml medicinal extract sample is for subsequent use, is divided into three groups: high dose group, middle dosage group, low dose group.
Chinese yam group, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd.Boiling, decocting liquid concentrates and is mixed with concentration is that 47g crude drug in whole/100ml medicinal extract sample is for subsequent use.
Fructus Hordei Germinatus group, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd.The process of Chinese yam same procedure is adopted to obtain sample for subsequent use.
Fennel seeds group, is provided by Luzhou Baicaotang Chinese Herbal Pieces Co., Ltd.The process of Chinese yam same procedure is adopted to obtain sample for subsequent use.
1.2 animal used as test KM mouse, Da Shuo bio tech ltd, Chengdu provides, and body weight 18-22g is male, the animal quality certification number: animal credit number: SCXK(river) 2008-24; SD rat, Chengdu University of Traditional Chinese Medicine's Experimental Animal Center provides, body weight 140g ~ 160g, male, the animal quality certification number: SCXK(river) 2008-11.
1.3 experiment reagents and electronics balance (thousand-island forest park, 0.1g); Loperamide hydrochloride (Xi'an Yang Sen company, lot number: 031014878); Gum arabic, prepared Chinese ink.
2 experimental techniques
2.1 impacts on intestinal motility
Male KM mouse 96, comprises 6 kinds of different dosing groups, blank group and model control group, every treated animal 12 by random point 8 groups.With 10 of human body consumption per day times (4.7g crude drug/kgBW), per os gives 12 kinds of different given the test agent, 1 time/d, continuous 15d, and blank group and model control group give experimental water by same volume.After given the test agent 15d, water 16h is can't help in the fasting of each group mouse.After 30min, model control group and each administration group gavage give compound diphenoxylate (5mg/kgBW), and blank group to experimental water.After compound diphenoxylate 30min, each administration group gives the prepared Chinese ink (activated carbon powder containing 5%, 10% gum arabic) containing corresponding given the test agent, and blank group and model control group give prepared Chinese ink.After giving prepared Chinese ink 25min, disconnected neck puts to death animal, anatomical isolation mesenterium, take out pylorus (upper end) to ileocecus (lower end) little intestinal tube, be placed in pallet, intestinal tube is gently drawn to be in line, measure total small intestinal length, prepared Chinese ink advances length (pylorus is to prepared Chinese ink forward position), is calculated as follows prepared Chinese ink impelling ratio (P) and ink progradation:
Prepared Chinese ink impelling ratio (P)=prepared Chinese ink advances length (cm)/total small intestinal length (cm)
Ink progradation
SPSS12.0 software is adopted to carry out statistical analysis to each proportioning group result and blank group, model control group.
2.2 impacts on digestive enzyme activity
Male SD rat 70, random point 7 groups, comprise 6 kinds of administration groups, blank group, every treated animal 10, the difference of the weight of animals should be no more than 10% of average weight.Per os gives different given the test agent, 1 time/d, continuous 30d, and blank group control group gives experimental water by same volume.After last administration, water 24h is can't help in each treated animal fasting, adopts etherization rat pylorus ligature law to collect the gastric juice of discharging in certain hour, gastric juice amount in the analytical unit time.Select internal diameter 1.5mm glass tube, inject Fresh Egg clear, put hot bath keeps flat make protein coagulating after take out, discard alveolate protein pipe, put Refrigerator store, make 3cm length before use.Get the conical flask that gastric juice 1mL puts into 50mL, add 0.05mol/L hydrochloric acid solution 15mL and shake up, put into the protein pipe two of made fresh.Be stoppered bottleneck, in 37 DEG C of insulating boxs, hatch 24h, take out protein pipe, measure the length (mm) of protein pipe two ends transparent part with chi, ask its mean value with the value of four ends.Calculate pepsin activity and pepsin discharge rate.
Pepsin activity unit (U/mL)=tetra-end protein pipe transparent part length average
2× 16
Pepsin discharge rate (U/h)=pepsin activity × gastric juice amount per hour
SPSS12.0 software is adopted to carry out statistical analysis to each proportioning group result and blank group, model control group.
3 experimental results
Different group to the experimental result of mouse small intestine motion effects in table 3:
The different group of table 3 is on the impact of mouse ink progradation
Note: compare with model control group, * P<0.05, * * P<0.01; Compare with middle dosage group,
△p < 0.05,
△ △p < 0.01.
From table 3, model control group prepared Chinese ink impelling ratio and propelling rate all remarkable in blank group (P<0.05), show that Constipated mice is set up.Compared with model control group, the high, medium and low dosage group of medicine/health food of the present invention all can significantly promote intestinal motility (P<0.05, P<0.01), wherein the ink progradation of high, middle dosage group to mouse has pole significant difference, acts on more obvious.Compared with dosage group in compound of the present invention, other simple groups all have significant difference (P<0.05 to the ink progradation of mouse, P<0.01), under showing Isodose condition, compound of the present invention promotes that the effect of intestinal motility is more excellent.
Different group to the sex experimental result of rat digestive enzyme in table 4:
The different group of table 4 is on the impact of rat digestive ferment
Note: compare with blank group, * P<0.05, * * P<0.01; Compare with middle dosage group,
△p < 0.05,
△ △p < 0.01.
From table 4, compared with blank group, medicine/health food of the present invention is high, in, the rat stomach protease discharge rate of low dose group has significant difference (P<0.05, P<0.01), and in, high dose group pole conspicuousness effect (P<0.01), can significantly or pole significantly improve rat stomach prolease activity, promote that rat gastric secretion increases (P<0.05, P<0.01), illustrate that the present composition is all better than each taste medicine and is used alone, in the present composition, each component has the effect of Synergistic.Compared with dosage group in compound of the present invention, other simple groups, to rat stomach prolease activity, promote that rat gastric juice secretion all has significant difference (P<0.05, P<0.01), under showing Isodose condition, compound effect of the present invention is more excellent.
To sum up, medicine/health food provided by the invention, by promoting intestinal motility, promoting gastric secretion, improving the number of ways such as peptic activity of stomach, significantly improves digestive functions.
Claims (7)
1. improve the food of digestive functions, health products or a pharmaceutical composition, it is characterized in that: it is the preparation be prepared from by the raw material of following weight proportion: Chinese yam 15 parts, 10 parts, Fructus Hordei Germinatus, fennel seeds 3 parts.
2. food according to claim 1, health products or pharmaceutical composition, it is characterized in that: it be by the medicinal powder of each bulk drug, the water of bulk drug or/and ethanol extract is active component, to add in pharmacy or health products the preparation that conventional auxiliary material is prepared from.
3. food according to claim 1 and 2, health products or pharmaceutical composition, is characterized in that: described preparation is oral formulations.
4. food according to claim 3, health products or pharmaceutical composition, is characterized in that: described oral formulations is paste, oral liquid, medicinal tea, granule, capsule, pill, tablet or powder.
5. the preparation method of food, health products or pharmaceutical composition described in Claims 1 to 4 any one, is characterized in that: it comprises the steps:
(1) each bulk drug is taken by weight ratio;
(2) each bulk drug directly pulverized or add water or/and after alcohol extract, adding auxiliary material conventional in pharmacy or health products, be prepared into conventional preparation.
6. food, health products or pharmaceutical composition described in Claims 1 to 4 any one are preparing the purposes in food, health products or the medicine improving digestive functions.
7. purposes according to claim 6, is characterized in that: described food, health products or medicine have to promote intestinal motility, gastric secretion, improves the food of peptic activity of stomach, health products or medicine.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1569118A (en) * | 2004-04-28 | 2005-01-26 | 南京中科生化技术有限公司 | Chinese traditional medicinal formulation for protecting alimentary tract mucosa |
| CN101766765A (en) * | 2008-12-30 | 2010-07-07 | 北京中科仁和科技有限公司 | Granule for treating children indigestion |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1569118A (en) * | 2004-04-28 | 2005-01-26 | 南京中科生化技术有限公司 | Chinese traditional medicinal formulation for protecting alimentary tract mucosa |
| CN101766765A (en) * | 2008-12-30 | 2010-07-07 | 北京中科仁和科技有限公司 | Granule for treating children indigestion |
Non-Patent Citations (1)
| Title |
|---|
| 田琳,等.调气中药对豚鼠体外胃平滑肌运动的影响.《中国中西医结合消化杂志》.2007,第15卷(第5期), * |
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