CN104189349B - Traditional Chinese medicine composition for treating oligomenorrhea - Google Patents
Traditional Chinese medicine composition for treating oligomenorrhea Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating oligomenorrhea. The traditional Chinese medicine composition is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 5-8 parts of codonopsis pilosula, 10-20 parts of fructus lycii, 10-16 parts of Chinese dodder seeds, 15-25 parts of rhizoma cyperi, 11-18 parts of hairyvein agrimony, 10-15 parts of white atractylodes rhizome, 8-15 parts of ligusticum wallichii, 3-7 parts of glossy privet fruit, 5-15 parts of eclipta alba, 15-25 parts of leonurus, 11-15 parts of radix paeoniae alba and 6-8 parts of trogopterus dung. The traditional Chinese medicine composition has compatible medicines which complement each other, has the efficacies of nourishing blood and astringing yin, soothing liver and regulating qi, enriching blood and promoting blood circulation, as well as regulating menstruation and relieving pain, and has the advantages of good curative effect on the oligomenorrhea caused by various disease causes, convenience in taking, no toxic or side effect and good conditioning effect on physical health.
Description
Technical field
The present invention relates to the medicine for the treatment of menoxenia, particularly relating to a kind of take vegetable Chinese herbal medicine as the Chinese medicine composition of the treatment Hypomenorrhea that raw material is made.
Background technology
Hypomenorrhea (hypomenorrhea) menstrual cycle is normal, and through measuring obvious minimizing, even drop is namely clean; Or menstrual period shorten less than two days, also lack person through amount, be all called " hypomenorrhea ", belong to menopathy.Normal and the delayed menstrual cycle of hypomenorrhea is also shown in, the normal companion body heavily increases.This disease betides adolescence and child-bearing period person can develop into amenorrhea, betides climacteric person and then often enters menopause.
General normal amount of menstrual bleeding should be 20 ~ 60 milliliters, and hypomenorrhea is hypomenorrhea in 20 milliliters.Probably estimate with the consumption of sanitary towel, normal consumption changes four or five times in average one day, and each cycle is no less than 1 bag (often wrapping 10 meters).If all cannotd be used up with Lian Banbao sanitary towel, so just belong to hypomenorrhea.
The hypomenorrhea of women, has void to have real two kinds from the angle of the traditional Chinese medical science, and empty person is many is impairment of the kidney because of congenital deficiency of kidney-QI or exhaustion due to sexual indulgence fecund.Deficiency of kidney-QI, essence and blood does not fill, and punching is appointed deficient, menoxenia due to insufficiency of CHONG meridian and cause hypomenorrhea; Also have originate not enough or prolonged illness serious disease of QI and blood to lose blood, so that the sea of blood is hollow, the weary source of menses and hypomenorrhea person.Reality person or because of blood stasis, or because of phlegm-damp, evil resistance vessels of the uterus collaterals of the uterus, hematogenous blockage, so that reduce through amount.These be all the traditional Chinese medical science think menstrual period Hypomenorrhea reason.
By the reason of Hypomenorrhea in these, some performances of Hypomenorrhea in menstrual period can also be inferred in menstrual period.Hypomenorrhea from the color of menstruation, matter and should distinguish its deficiency and excess with or without stomachache etc.General light through color, matter is rare, abdomen without distending pain person, be void; Dark menses, folder clot, stomachache person are blood; Light red through color, matter is sticky, obesity person, is phlegm-damp.The person that belongs to congenital defect is few through water element; The day after tomorrow damages the wounded, then reduce gradually through water.Suddenly through amount minimizing person, then excess syndrome mostly is.Also unexpected serious disease exhaustion of blood is had, and the withered infrequent menstruation of hyperamization, even amenorrhea person.Primary disease deficiency syndrome are many, and excess syndrome is few.Therefore treatment focuses on nourishing kidney and nourishes blood, menses of supplementing nutrition, makes abundant CHONG meridian with unobstructed REN meridian, sea of blood spill-over.Even inventor thinks the stagnant or phlegm-damp of the stasis of blood, carefully can not to cross with breaking through, in order to avoid severely injured QI and blood, making through difficulty in resuming blood.
Summary of the invention
Inventor is according to oneself tcm clinical practice experience for many years, sum up the Couple herbs of traditional proved recipe and case, the pathogenic factor of modern of concentrating on studies and characteristics of incidence, again compatibility Chinese medicine, there is provided a kind of and have that nourishing kidney is nourished blood, depressed liver-energy dispersing and QI regulating, enrich blood invigorate blood circulation, the Chinese medicine preparation of menstruction regulating and pain relieving effect, the menstrual blood volume caused for the various cause of disease is very few all has good efficacy, and taking convenience, without any side effects.
Present invention employs following technical scheme:
A kind of Chinese medicine composition for the treatment of Hypomenorrhea, it is made up of Radix Codonopsis, Fructus Lycii, Semen Cuscutae, Rhizoma Cyperi, Herba Agrimoniae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Leonuri, the Radix Paeoniae Alba, Oletum Trogopterori 12 taste Chinese medicine, Chinese medicine composition reasonable recipe of the present invention, evident in efficacy, reliable effect, has no side effect.
The concrete pharmacology analysis of each component of the present invention is as follows:
Radix Codonopsis: tool invigorating the spleen and replenishing QI, stomach function regulating such as to nourish blood at the effect, because QI invigorating also contributes to hemopoietic, so Radix Codonopsis is also applicable to QI and blood deficiency pale complexion, lightheaded people.
Fructus Lycii: have the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, effect of nourishing the lung to arrest cough, cures mainly hepatic and renal YIN deficiency, and soreness of the waist and knees is quenched one's thirst, the diseases such as cough due to consumptive disease.
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Function cures mainly: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast.
Herba Agrimoniae: bitter, cool.Return stomach, liver, spleen, lung, large intestine channel.Function cures mainly: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, control epistaxis and have specially good effect, malaria, de-power impairment caused by overstrain, carbuncle.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The effects such as the Rhizoma Atractylodis Macrocephalae has adjustment gastrointestinal motility function, antiulcer, protects the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of suppression uterine contraction.The Rhizoma Atractylodis Macrocephalae also has the effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor.
Rhizoma Chuanxiong: there is blood-activating and qi-promoting, effect of wind-expelling pain-stopping, for menoxenia, amenorrhea dysmenorrhea, the diseases such as lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body.
Fructus Ligustri Lucidi: property is put down, sweet in the mouth, hardship, function replenishing kidney-YIN, nourishing the liver tomorrow, is applicable to the dizziness of the hepatic and renal YIN deficiency, tinnitus, soreness of the waist and knees, early whitening of beard and hair, and two blurred visions are stuck with paste, visual deterioration etc.
Herba Ecliptae: sweet in the mouth, acid, cool in nature.Gui Jing: kidney channel, Liver Channel.Effect: nourishing the liver and kidney, crow palpus teeth consolidating, cooling blood for hemostasis.Cure mainly: deficiency of the liver and kindey, vertigo and tinnitus, blurring of vision, soreness of the waist and knees, turn white luxated tooth, stranguria caused by overstrain foul leukorrhea, spitting of blood, spits blood, epistaxis, hematuria, dysentery, metrorrhagia, traumatic hemorrhage.
Herba Leonuri: bitter, pungent, is slightly cold.Return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
The Radix Paeoniae Alba: cool in nature, bitter in the mouth acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.
Oletum Trogopterori: sweet, temperature.Function cures mainly: promoting blood circulation to remove blood stasis, and parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.
The consumption of the composition of the Chinese medicine composition for the treatment of Hypomenorrhea provided by the invention is that inventor's process gropes to sum up to get for a long time in a large number, and each component consumption all has good curative effect in following weight parts.
A kind of Chinese medicine composition for the treatment of Hypomenorrhea, it is characterized in that, it is made up of the raw material of Chinese medicine of following weight: Radix Codonopsis 5-8 part, Fructus Lycii 10-20 part, Semen Cuscutae 10-16 part, Rhizoma Cyperi 15-25 part, Herba Agrimoniae 11-18 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Chuanxiong 8-15 part, Fructus Ligustri Lucidi 3-7 part, Herba Ecliptae 5-15 part, Herba Leonuri 15-25 part, Radix Paeoniae Alba 11-15 part, Oletum Trogopterori 6-8 part.
Preferably, the Chinese medicine composition for the treatment of Hypomenorrhea described above, it is characterized in that, it is made up of the raw material of Chinese medicine of following weight: Radix Codonopsis 6 parts, Fructus Lycii 16 parts, Semen Cuscutae 15 parts, Rhizoma Cyperi 22 parts, Herba Agrimoniae 15 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Rhizoma Chuanxiong 11 parts, Fructus Ligustri Lucidi 5 parts, Herba Ecliptae 10 parts, Herba Leonuri 20 parts, the Radix Paeoniae Alba 13 parts, Oletum Trogopterori 7 parts.
Fang Xie: side in Rhizoma Cyperi, Herba Leonuri altogether for monarch drug, resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving; Radix Codonopsis invigorating the spleen and replenishing QI, stomach function regulating are nourished blood, and Herba Agrimoniae tonify deficiency astringent therapy, the lid deficiency of vital energy are just lost, and help with Radix Paeoniae Alba blood-supplementing blood-nourishing, suppressing liver-YANG, Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Oletum Trogopterori promoting blood circulation to remove blood stasis; Fructus Ligustri Lucidi, Herba Ecliptae are added with YIN nourishing, Fructus Lycii, Semen Cuscutae with supporing yang, reach tonifying both YIN and YANG, regulate body, make inherently to change body constitution, reaching the yin fluid astringing that nourishes blood, depressed liver-energy dispersing and QI regulating, enrich blood invigorate blood circulation, menstruction regulating and pain relieving, nourishing YIN is supporing yang, the object for the treatment of both the principal and secondary aspects of a disease.
Modern pharmacology also studies confirmation, this Chinese medicine composition have nourish blood, QI invigorating, regulating menstruation effect.
Present invention also offers a kind of method preparing the Chinese medicine composition for the treatment of Hypomenorrhea, Chinese medicine composition of the present invention can adopt but be not limited to following methods: processed through extraction or other modes by the raw material of Chinese medicine formed by above-mentioned formula, make pharmaceutically active substance, subsequently, with this material for raw material, add medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.
Wherein, active substance described above can obtain by extracting raw material of Chinese medicine respectively, also can be obtained by the common raw material of Chinese medicine that extracts, also can obtain by other means, as: by pulverizing, squeezing, calcine, grind, sieve, percolation, extraction, water extraction, alcohol extraction, ester carry, the material that method obtains, these active substances can be extractum form such as ketone is carried, chromatography, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.
Preferably, a kind of method preparing the Chinese medicine composition for the treatment of Hypomenorrhea, is characterized in that, comprise the following steps:
(1) accurately take according to described Chinese prescription above: Radix Codonopsis, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, pulverize, mix, add the alcohol reflux 2 ~ 4 times that determining alcohol is 65 ~ 75%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, leave standstill, get supernatant, concentrating under reduced pressure becomes relative density to be 1.05 ~ 1.10 (60 DEG C) thick paste, and the quality adding ethanol is 3 ~ 5 times of mixture quality;
(2) accurately take according to described Chinese prescription above: Fructus Lycii, Semen Cuscutae, Herba Agrimoniae, Rhizoma Chuanxiong, Herba Ecliptae, Herba Leonuri, the Radix Paeoniae Alba are pulverized, mixing, decoct with water extraction 2 ~ 4 times, each decocting time is 1 ~ 2 hour, merge extractive liquid, filter, leave standstill, get supernatant, concentrating under reduced pressure becomes the thick paste of relative density 1.05 ~ 1.12 (60 DEG C), and the quality added water is 3 ~ 7 times of mixture quality;
(3) thick paste mixing step (1) and step (2) obtained, crushed after being dried is also screened into 80 order ~ 100 object fine powders;
(4) accurately take according to described Chinese prescription above: Oletum Trogopterori, pulverize, cross 100 mesh sieves; Then the fine powder obtained with step (3) is mixed homogeneously, and obtains Chinese medicine composition of the present invention.
The Chinese medicine composition for the treatment of Hypomenorrhea of the present invention can be made into peroral dosage form described on any one pharmaceutics.
Peroral dosage form described above comprises: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, granule, electuary, pill, powder, suspensoid, solution.
Preferably, peroral dosage form described above is the one in soft capsule, capsule, tablet, oral liquid, granule.
Consider the factors such as recipe quantity, pharmaceutical properties, medication object, easy to use, cost of manufacture, preferably, the Chinese medicine composition for the treatment of essential hypotension of the present invention can be made into capsule, granule.
Prepare a method for the Chinese medicine capsules for the treatment of Hypomenorrhea, it is characterized in that, comprise the following steps:
(1) accurately take according to described Chinese prescription above: Radix Codonopsis, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, pulverize, mix, add the alcohol reflux 2 ~ 4 times that determining alcohol is 65 ~ 75%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, leave standstill, get supernatant, concentrating under reduced pressure becomes relative density to be 1.05 ~ 1.10 (60 DEG C) thick paste, and the quality adding ethanol is 3 ~ 5 times of mixture quality;
(2) accurately take according to described Chinese prescription above: Fructus Lycii, Semen Cuscutae, Herba Agrimoniae, Rhizoma Chuanxiong, Herba Ecliptae, Herba Leonuri, the Radix Paeoniae Alba are pulverized, mixing, decoct with water extraction 2 ~ 4 times, each decocting time is 1 ~ 2 hour, merge extractive liquid, filter, leave standstill, get supernatant, concentrating under reduced pressure becomes the thick paste of relative density 1.05 ~ 1.12 (60 DEG C), and the quality added water is 3 ~ 7 times of mixture quality;
(3) thick paste mixing step (1) and step (2) obtained, crushed after being dried is also screened into 80 order ~ 100 object fine powders;
(4) accurately take according to described Chinese prescription above: Oletum Trogopterori, pulverize, cross 100 mesh sieves; Then the fine powder obtained with step (3) and appropriate adjuvant are mixed homogeneously, and granulate, and dry, encapsulated shell, obtains capsule.
Prepare a method for the Chinese medicine granules for the treatment of Hypomenorrhea, it is characterized in that, comprise the following steps:
(1) accurately take according to described Chinese prescription above: Radix Codonopsis, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, pulverize, mix, add the alcohol reflux 2 ~ 4 times that determining alcohol is 65 ~ 75%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, leave standstill, get supernatant, concentrating under reduced pressure becomes relative density to be 1.05 ~ 1.10 (60 DEG C) thick paste, and the quality adding ethanol is 3 ~ 5 times of mixture quality;
(2) accurately take according to described Chinese prescription above: Fructus Lycii, Semen Cuscutae, Herba Agrimoniae, Rhizoma Chuanxiong, Herba Ecliptae, Herba Leonuri, the Radix Paeoniae Alba are pulverized, mixing, decoct with water extraction 2 ~ 4 times, each decocting time is 1 ~ 2 hour, merge extractive liquid, filter, leave standstill, get supernatant, concentrating under reduced pressure becomes the thick paste of relative density 1.05 ~ 1.12 (60 DEG C), and the quality added water is 3 ~ 7 times of mixture quality;
(3) thick paste mixing step (1) and step (2) obtained, crushed after being dried is also screened into 80 order ~ 100 object fine powders;
(4) accurately take according to described Chinese prescription above: Oletum Trogopterori, pulverize, cross 100 mesh sieves; Then the fine powder obtained with step (3) and appropriate adjuvant are mixed homogeneously, and granulate, dry, and pack, obtains granule.
Chinese medicine composition described above can be effective to preparation treatment Hypomenorrhea medicine, realizes the application of this Chinese medicine composition in the medicine of preparation treatment Hypomenorrhea.
Beneficial effect of the present invention: Chinese medicine composition of the present invention has the yin fluid astringing that nourishes blood, depressed liver-energy dispersing and QI regulating, enrich blood invigorate blood circulation, menstruction regulating and pain relieving effect, the menstrual blood volume caused for the various cause of disease is very few all has good efficacy, and taking convenience, without any side effects, also have good opsonic action to healthy.
Detailed description of the invention
Embodiment 1 Chinese medicinal composition granules of the present invention
Take Radix Codonopsis 6g, Rhizoma Cyperi 22g, Rhizoma Atractylodis Macrocephalae 13g, Fructus Ligustri Lucidi 5g, pulverize, mix, add the alcohol reflux 2 ~ 4 times that determining alcohol is 65 ~ 75%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, leave standstill, get supernatant, concentrating under reduced pressure becomes relative density to be 1.05 ~ 1.10 (60 DEG C) thick paste, and the quality adding ethanol is 3 ~ 5 times of mixture quality; Take Fructus Lycii 16g, Semen Cuscutae 15g, Herba Agrimoniae 15g, Rhizoma Chuanxiong 11g, Herba Ecliptae 10g, Herba Leonuri 20g, Radix Paeoniae Alba 13g pulverizing, mixing, decoct with water extraction 2 ~ 4 times, each decocting time is 1 ~ 2 hour, merge extractive liquid, filter, leave standstill, get supernatant, concentrating under reduced pressure becomes the thick paste of relative density 1.05 ~ 1.12 (60 DEG C), and the quality added water is 3 ~ 7 times of mixture quality; Mixed by the thick paste of above-mentioned acquisition, crushed after being dried is also screened into 80 order ~ 100 object fine powders; Take Oletum Trogopterori 7g, pulverize, cross 100 mesh sieves; Then mix homogeneously with fine powder obtained above and appropriate adjuvant, granulate, dry, pack, obtain the granule 10 bags of 10g/ bag, every bag is equivalent to crude drug 15.3g.
Embodiment 2 Chinese medicinal composition capsules agent of the present invention
Take Radix Codonopsis 6g, Rhizoma Cyperi 22g, Rhizoma Atractylodis Macrocephalae 13g, Fructus Ligustri Lucidi 5g, pulverize, mix, add the alcohol reflux 2 ~ 4 times that determining alcohol is 65 ~ 75%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, leave standstill, get supernatant, concentrating under reduced pressure becomes relative density to be 1.05 ~ 1.10 (60 DEG C) thick paste, and the quality adding ethanol is 3 ~ 5 times of mixture quality; Take Fructus Lycii 16g, Semen Cuscutae 15g, Herba Agrimoniae 15g, Rhizoma Chuanxiong 11g, Herba Ecliptae 10g, Herba Leonuri 20g, Radix Paeoniae Alba 13g pulverizing, mixing, decoct with water extraction 2 ~ 4 times, each decocting time is 1 ~ 2 hour, merge extractive liquid, filter, leave standstill, get supernatant, concentrating under reduced pressure becomes the thick paste of relative density 1.05 ~ 1.12 (60 DEG C), and the quality added water is 3 ~ 7 times of mixture quality; Mixed by the thick paste of above-mentioned acquisition, crushed after being dried is also screened into 80 order ~ 100 object fine powders; Take Oletum Trogopterori 7g, pulverize, cross 100 mesh sieves; Then mix homogeneously with fine powder obtained above and appropriate adjuvant, granulate, dry, load 0 capsule shells, obtain the capsule 100 of 0.5g, every is equivalent to crude drug 1.53g.
Embodiment 3 Chinese medicinal composition capsules agent of the present invention
Take Radix Codonopsis 5g, Rhizoma Cyperi 15g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Ligustri Lucidi 3g, pulverize, mix, add the alcohol reflux 2 ~ 4 times that determining alcohol is 65 ~ 75%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, leave standstill, get supernatant, concentrating under reduced pressure becomes relative density to be 1.05 ~ 1.10 (60 DEG C) thick paste, and the quality adding ethanol is 3 ~ 5 times of mixture quality; Take Fructus Lycii 10g, Semen Cuscutae 10g, Herba Agrimoniae 10g, Rhizoma Chuanxiong 8g, Herba Ecliptae 5g, Herba Leonuri 15g, Radix Paeoniae Alba 11g pulverizing, mixing, decoct with water extraction 2 ~ 4 times, each decocting time is 1 ~ 2 hour, merge extractive liquid, filter, leave standstill, get supernatant, concentrating under reduced pressure becomes the thick paste of relative density 1.05 ~ 1.12 (60 DEG C), and the quality added water is 3 ~ 7 times of mixture quality; Mixed by the thick paste of above-mentioned acquisition, crushed after being dried is also screened into 80 order ~ 100 object fine powders; Take Oletum Trogopterori 6g, pulverize, cross 100 mesh sieves; Then mix homogeneously with fine powder obtained above and appropriate adjuvant, granulate, dry, incapsulate shell, obtain capsule.
Embodiment 4 Chinese medicinal composition capsules agent of the present invention
Take Radix Codonopsis 8g, Rhizoma Cyperi 25g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Ligustri Lucidi 7g, pulverize, mix, add the alcohol reflux 2 ~ 4 times that determining alcohol is 65 ~ 75%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, leave standstill, get supernatant, concentrating under reduced pressure becomes relative density to be 1.05 ~ 1.10 (60 DEG C) thick paste, and the quality adding ethanol is 3 ~ 5 times of mixture quality; Take Fructus Lycii 20g, Semen Cuscutae 16g, Herba Agrimoniae 18g, Rhizoma Chuanxiong 15g, Herba Ecliptae 15g, Herba Leonuri 25g, Radix Paeoniae Alba 15g pulverizing, mixing, decoct with water extraction 2 ~ 4 times, each decocting time is 1 ~ 2 hour, merge extractive liquid, filter, leave standstill, get supernatant, concentrating under reduced pressure becomes the thick paste of relative density 1.05 ~ 1.12 (60 DEG C), and the quality added water is 3 ~ 7 times of mixture quality; Mixed by the thick paste of above-mentioned acquisition, crushed after being dried is also screened into 80 order ~ 100 object fine powders; Take Oletum Trogopterori 8g, pulverize, cross 100 mesh sieves; Then mix homogeneously with fine powder obtained above and appropriate adjuvant, granulate, dry, incapsulate shell, obtain capsule.
Embodiment 5 pharmacodynamic experiment
One, on the impact of blood deficiency mouse blood
1. Experimental agents:
Granule prepared by the embodiment of the present invention 1,2.0,1.0,0.5g/kg body weight (namely 6.12,3.06,1.53g crude drug in whole/kg three dosage groups are established in experiment:, be equivalent to 24,12,6 times of every daily clinical dosage respectively, adult 60kg, daily be equivalent to crude drug 15.3g) get the medicinal liquid that distilled water is mixed with respective concentration, for subsequent use.
WUJI BAIFENG WAN: Chinese medicine positive control medicine, is produced by Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd, the accurate word Z11020026 of traditional Chinese medicines.Specification: every 100 heavy 12 grams, often bottled 36 grams.During experiment, distilled water is mixed with the medicinal liquid that concentration is 0.3g/ml, for subsequent use.
2. laboratory animal: KM mice, entirely female, body weight (20 ± 2) g, is provided by Shandong University's Experimental Animal Center, for subsequent use after quarantine.
3. experimental technique
Grouping: get 50 mices, after conforming one week, be divided into model group (N=10) at random, granule high dose group (N=10), middle dosage group (N=10), low dose group (N=10) and WUJI BAIFENG WAN group (N=10) prepared by the embodiment of the present invention 1.
Modeling and administration: afterbody blood-letting 0.5ml respectively, animal is lost blood, after losing blood 24h again afterbody get blood and survey Hb, RBC and observe the degree of blood deficiency of causing, the granule of the embodiment of the present invention 1 preparation is simultaneously high, in, low dose group and WUJI BAIFENG distinguish the corresponding medicine of gavage through ball group, the isodose normal saline of model group gavage, successive administration 7 days.
Specimen sampling and Indexs measure: after last administration 2h, then afterbody gets the value that blood surveys Hb and RBC.Above experimental data is all analyzed with SPSS13.0 statistical software.
4. experimental result
Table 1 is on the impact of Lost blood anemia mouse blood
Note: * * P < 0.01 compared with model group; With WUJI BAIFENG WAN group than #P < 0.05.
Learnt by table 1, after the 24h that loses blood, Hb and RBC of model group and administration group, significantly lower than matched group (P < 0.01), illustrates the success of hemopoietic virtual model.There was no significant difference between Hb and RBC between 4 groups, modeling type, before treatment is described, each group of situation of losing blood is consistent.After administration 7d, granule group of the present invention and WUJI BAIFENG WAN group can significantly improve Hb and RBC level, have pole significant difference (P < 0.01) compared with matched group; Granule heavy dose group of the present invention has significant difference (P < 0.05) compared with WUJI BAIFENG WAN group.Visible, granule group of the present invention is stronger than the blood tonification effect of WUJI BAIFENG WAN group.
Two, on the impact of young female rat gonadal hormone
1. laboratory animal: SD rat, female sex immature, body weight 81 ~ 107g.
2, medicine: granule prepared by the embodiment of the present invention 1,2.0,1.0,0.5g/kg body weight (namely 6.12,3.06,1.53g crude drug in whole/kg three dosage groups are established in experiment:, be equivalent to 24,12,6 times of every daily clinical dosage respectively, adult 60kg, daily be equivalent to crude drug 15.3g) get the medicinal liquid that distilled water is mixed with respective concentration, for subsequent use.
WUJI BAIFENG WAN: Chinese medicine positive control medicine, is produced by Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd, the accurate word Z11020026 of traditional Chinese medicines.Specification: every 100 heavy 12 grams, often bottled 36 grams.During experiment, distilled water is mixed with the medicinal liquid that concentration is 0.3g/ml, for subsequent use.
3. experimental technique
Female sex immature SD rat 50, body weight 81 ~ 107g, is divided into 5 groups at random, often organizes 10.The normal saline of matched group gavage same volume; Granule prepared by the embodiment of the present invention 1 is high, in, low dose group and WUJI BAIFENG are through the ball group medicine that gavage is corresponding respectively, and successive administration 7d, every day 1 time, after last administration 1h, each Mus is taken a blood sample after weighing.Get the content that serum radioimmunoassay method measures serum estradiol (E2).Above experimental data is all analyzed with SPSS13.0 statistical software.
4. experimental result:
Table 2 swashs the impact of rope to young female rat
Note: * * P < 0.01 compared with matched group; With WUJI BAIFENG WAN group than ##P < 0.01.
Result shows: groups of grains of the present invention and WUJI BAIFENG WAN group can significantly improve the level of young female rat serum estradiol, has pole significant difference (P < 0.01) compared with matched group; Granule of the present invention heavy dose group has been compared with WUJI BAIFENG WAN group significant difference (P < 0.01).Visible, the horizontal force that this groups of grains improves gonadal hormone than WUJI BAIFENG WAN group is strong.
Three, to the effect of mouse anti-reflecting fatigue
1. Experimental agents: capsule prepared by the embodiment of the present invention 2,2.0,1.0,0.5g/kg body weight (namely 6.12,3.06,1.53g crude drug in whole/kg three dosage groups are established in experiment:, be equivalent to 24,12,6 times of every daily clinical dosage respectively, adult 60kg, daily be equivalent to crude drug 15.3g) get the medicinal liquid that distilled water is mixed with respective concentration, for subsequent use.
Ginsenoside: positive drug, commercially available, face used time distilled water and be mixed with the medicinal liquid that concentration is 0.01g/ml, for subsequent use.
2. laboratory animal: KM mice 50, entirely female, body weight (22 ± 2) g, is provided by Shandong University's Experimental Animal Center, for subsequent use after quarantine.
3. experimental technique (test of the mice limit food method deficiency of vital energy)
Grouping: get 50 mices, after conforming one week, the capsule in high dose group (N=10), middle dosage group (N=10), the low dose group (N=10) that are divided into matched group (N=10), ginsenoside's group (N=10), the embodiment of the present invention 2 to prepare at random by body weight.
Modeling and administration: feed according to 100g/kg limitation of food intake for each group, continue 7 days; Blank group and model group gavage every day normal saline, other group corresponding medicinal liquid of gavage respectively simultaneously, dosage is 10ml/kg body weight.Indexs measure: after the 7th afternoon administration 1h, puts into mice after activity observation instrument stablizes 1 minute, surveys the Assay of spontaneous activity in three minutes.Morning next day at the water vat went swimming of water temperature 20 DEG C, depth of water 35cm, the cap nut of mouse tail root Shu Yichong 1.0g.Timing from mice puts into water, can not float for its swimming time for 10 seconds in mice submerges water.Above data are all analyzed with SPSS13.0 statistical software.
4 experimental results
The effect of table 3 pair mouse anti-reflecting fatigue
Note: * * P < 0.01 compared with matched group; With WUJI BAIFENG WAN group than #P < 0.05.
Result shows: Capsules group of the present invention and ginsenoside's group group obviously can extend the walking weight load of mice, and have a certain amount of effect relationship, and dosage is larger, and walking weight load is longer.Pole significant difference (P < 0.01) is had compared with matched group; Capsule of the present invention heavy dose group has been compared with ginsenoside's group significant difference (P < 0.05).The antifatigue effect that Capsules group of the present invention is organized than eight ginsenosides is strong.
Four, acute toxicity testing result shows: by granule Cmax of the present invention, maximum volume gastric infusion, successive administration 3 times in 24h, every minor tick 4h, and accumulation medicine total amount reaches 15.3g crude drug/kg, is equivalent to 60 times of clinical plan consumption.After administration in 7d, mice activity, feed, excretion are all normal, well-grown, and hair color light, its average body weight average increases with the prolongation of test period.8d place post mortem every the mice perusal heart, liver, spleen, lung, kidney, brain, thymus, adrenal gland, stomach, intestinal etc. all do not find color and paramophia.Show that Chinese medicine composition of the present invention is without acute toxic reaction.
Embodiment 6 clinical effectiveness example
Physical data: 60 routine patients, age 16-45 year, the course of disease is many at 3 months to 2 years, 35.7 years old mean age, all carries out B ultrasonic, gynecologial examination and vaginal secretions routine examination during patient assessment, result prompting have no organic disease.
Diagnostic criteria:
" Chinese medical disease Standardization of diagnosis and curative effect " that diagnosis basis State Administration of Traditional Chinese Medicine issues: hypomenorrhea.
Discharge standard: the menoxenia person that exclusion standard causes for genitals's organic disease (hysteromyoma, adenomyosis, pituitary tumor etc.) on inspection; Be associated with severe primary disease and the psychotics such as cardiovascular, liver, kidney and hemopoietic system; Allergic constitution or to multi-medicament allergy sufferers.
Therapeutic Method: Chinese medicinal capsule prepared by the embodiment of the present invention 2, three times on the one, a 3-4 grain.
4, therapeutic outcome:
Formulate with reference to " Chinese medicine Clinical Researches of New Drugs guideline ":
Cure: menstrual cycle, recover normal, other transference cures through amount, menstrual period;
Effective: before amount comparatively treatment, increase 1/3, menstrual period recover within 7d, other transference cures or alleviate;
Take a turn for the better: through measuring, comparatively treating front improvement menstrual period after treatment, other symptoms alleviate before comparatively treating;
Invalid: menstrual cycle after treatment, through amount, menstrual period are without improvement.
Result: in 60 routine patients, cures 45 examples (75.0%), effective 10 examples (16.67%), and take a turn for the better 4 examples
(6.67%), invalid 1 example (1.67%), total effective rate is 98.3%.
Claims (4)
1. treat the Chinese medicine composition of Hypomenorrhea for one kind, it is characterized in that, it is made up of the raw material of Chinese medicine of following weight: Radix Codonopsis 6 parts, Fructus Lycii 16 parts, Semen Cuscutae 15 parts, Rhizoma Cyperi 22 parts, Herba Agrimoniae 15 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Rhizoma Chuanxiong 11 parts, Fructus Ligustri Lucidi 5 parts, Herba Ecliptae 10 parts, Herba Leonuri 20 parts, the Radix Paeoniae Alba 13 parts, Oletum Trogopterori 7 parts.
2. the Chinese medicine composition for the treatment of Hypomenorrhea as claimed in claim 1, is characterized in that, the Chinese medicine composition of described treatment Hypomenorrhea can be made into peroral dosage form described on any one pharmaceutics.
3. the Chinese medicine composition for the treatment of Hypomenorrhea as claimed in claim 2, it is characterized in that, described peroral dosage form is the one in capsule, tablet, oral liquid, granule.
4. the Chinese medicine composition for the treatment of Hypomenorrhea as claimed in claim 3, it is characterized in that, described peroral dosage form is capsule.
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