CN102614426B - Medicinal preparation for helping digestion and removing stagnation - Google Patents
Medicinal preparation for helping digestion and removing stagnation Download PDFInfo
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- CN102614426B CN102614426B CN201210107913.4A CN201210107913A CN102614426B CN 102614426 B CN102614426 B CN 102614426B CN 201210107913 A CN201210107913 A CN 201210107913A CN 102614426 B CN102614426 B CN 102614426B
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Abstract
The invention discloses a medicinal preparation and a preparation method for helping digestion and removing stagnation. Ingredients and proportioning of the medicinal preparation are 120g to 180g of codonopsis pilosula, 100g to 150g of rhizoma atractylodis, 120g to 180g of bighead atractylodes rhizome, 50g to 100g of ripe rhubarb, 120g to 180g of fried hawthorn, 120g to 180g of medicated leaven, 30g to 80g of platycodon grandiflorum, 120g to 180g of coloured malt and 30g to 80g of liquorice. The medicinal preparation is reasonable in formula and good in curative effect.
Description
Technical field
The invention belongs to Chinese medicine patent medicine preparing technical field.
Background technology
Taste are source of generating QI and blood, the hinge of mechanism of qi discrepancy.In stagnation of QI in spleen and stomach, food stagnation, stopping is commonly encountered diseases, frequently-occurring disease, especially children's this disease that is easy to get.Show as gastral cavilty feeling of fullness, breast side of body feeling of distension and oppression, fatigue and weakness; Belch, acid regurgitation, eructation or vow gas after alleviate, lack of appetite is indigestion and loss of appetite; Pale tongue, white and thin fur, stringy and rolling pulse.Be mainly due to eating and drinking without temperance, stagnate in interior; Or because waste heat after fever caused by exogenous pathogenic factors is unclear, expectorant retention of damp-heat in the interior, affects transporting and transforming function of the spleen and stomach.Be that children's is mainly that the feed of over loading ground or cold warm discomfort etc. cause because digestant for baby function is perfect and dietary structure is unreasonable.Infantile anorexia is current usual diseases of childhood, frequently-occurring disease.Often, with inappetence or anorexia, become thin, shallow complexion, umbilicus is pain around, the dysphoria with smothery sensation of sleeping night uneasiness, grinds one's teeth in sleep, the irritated irritability of emotion and weak and sickly be main clinical manifestation.The single symptom appearance of some infants, a plurality of symptoms of some infants merge simultaneously.Severe patient can cause malnutrition and multivitamin and trace element deficiency, affects children's upgrowth and development, causes children's's " emaciation and sallow complexion, short ", is the problem that the current head of a family extremely pays close attention to.Present children's's food is that category is numerous and diverse, and head of a family fondling is anxious in addition, having additional nutrients simply, allow child eat nourishing food more, day by day, finally cause spleen and stomach function to can't bear to bear a heavy burden, spleen rises the normal order multilated that stomach falls, and just occurs above-mentioned syndrome thereupon.
The traditional Chinese medical science claims that anorexia is indigestion and loss of appetite, and main cause is dysfunction of spleen and stomach.Due to emptiness of spleen and stomach, or improper feeding, eating and drinking without temperance injure due to taste, alleviates taste burden during treatment as far as possible, eliminates taste stagnant, goes back spleen and rise the normal transportation capabilities that stomach falls.Infantile anorexia is more common in department of pediatrics, and many children belong to the food stagnation impairment of the spleen type in apositia, as long as Therapeutic Method is proper, all can cure, and particularly use treatment by Chinese herbs primary disease, better efficacy.Blindly have Western medicine this disease done harm rather than good, and suitably take function of spleen and stomach regulating, the Chinese medicine of facilitating digestion absorption function.
The existing digestant medicine in medical market is many, but curative effect is not very desirable, and the reason such as taste bad will is taken inconvenience.
Summary of the invention
First object of the present invention is to provide a kind of pharmaceutical preparation of dyspepsia and intestinal stasis relieving, and rationally, therapeutical effect is good for this kind of pharmaceutical preparation formula.
The present invention realizes the technical scheme that first goal of the invention adopts: a kind of pharmaceutical preparation of dyspepsia and intestinal stasis relieving, the composition of its medicine material and proportioning are: Radix Codonopsis 120-180g, Rhizoma Atractylodis 100-150g, Rhizoma Atractylodis Macrocephalae 120-180g, Radix Et Rhizoma Rhei 50-100g, Fructus Crataegi (parched) 120-180g, Massa Medicata Fermentata 120-180g, Radix Platycodonis 30-80g, Fructus Hordei Germinatus (parched) 120-180g, Radix Glycyrrhizae 30-80g.
The proportioning of above-mentioned medicine material is: Radix Codonopsis 150g, Rhizoma Atractylodis 120g, Rhizoma Atractylodis Macrocephalae 150g, Radix Et Rhizoma Rhei 80g, Fructus Crataegi (parched) 150g, Massa Medicata Fermentata 150g, Radix Platycodonis 60g, Fructus Hordei Germinatus (parched) 150g, Radix Glycyrrhizae 60g.
Compared with prior art, the invention has the beneficial effects as follows:
Medicine of the present invention be take Radix Codonopsis as monarch drug, and Radix Codonopsis is sweet, tepor; Enter spleen, lung meridian; Invigorating the spleen and replenishing QI, strengthening the spleen and stomach.
Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei are ministerial drug: the high former > > of < < book on Chinese herbal medicine records, the Rhizoma Atractylodis Macrocephalae is excellent, Rhizoma Atractylodis are bad, all wish spleen reinforcings, use the Rhizoma Atractylodis Macrocephalae, all wish activating the spleen, use Rhizoma Atractylodis, wish is mended fortune and is held concurrently mutually, holds concurrently mutually and uses.Two medicine compatibilities, through-supplementation, one rise and one drop, reaches middle Jiao, activating the spleen dehumidifying.Radix Et Rhizoma Rhei " is cleansed the intestines and stomach, is pushed away Chen Zhixin ", its logical internal organs, except the turbid poison of dyspepsia phlegm retention make taste peace and, therefore there is the effect of stomach invigorating in tune, peace and the five internal organs.According to modern pharmacological research: Radix Et Rhizoma Rhei has stomach invigorating and digestion-aid effect.Research shows, Radix Et Rhizoma Rhei, containing amaroid, is taken low dose of powder and can be promoted gastric secretion and have stomach invigorating digestion-aid effect.The products such as existing rhubarb tincture, Extractum Rhei Liquidum are widely used in clinical, treatment inappetence, the diseases such as dyspepsia.
Take Radix Platycodonis, Fructus Crataegi, Fructus Hordei Germinatus (parched), Massa Medicata Fermentata is adjuvant drug.Radix Platycodonis lung qi dispersing, sensible in order to temper.The sweet salty temperature of Crataegolic acid, spleen invigorating circulation of qi promoting, dissipating blood stasis reduces phlegm, and the mill that helps digestion is long-pending; Greasy, the smelling of fish or mutton of disappearing is long-pending.The salty temperature of Fructus Hordei Germinatus, can help gastric qi up, and the strong fortune of money; The wide intestinal of spleen reinforcing, regulating middle-JIAO and making the adverse QI downward, the de-swelling that helps digestion, eliminating stagnation is eliminated the phlegm; Salty energy softening the hard mass, changes all rice and flour fruit food stagnations.Massa Medicata Fermentata digesting and absorbing the essence of foodstuff dyspepsia, Disorder knot is stagnant, spleen invigorating warming the stomach.
Fructus Crataegi (parched), Fructus Hordei Germinatus (parched), Massa Medicata Fermentata three medicines share, and have the function that strengthens significantly digestion for rice and flour food stagnation, meat stagnation person.Radix Glycyrrhizae is spleen reinforcing stomach function regulating first, second relaxes Radix Et Rhizoma Rhei and rushes down purgation power, therefore three coordinating the actions of various ingredients in a prescription are for making medicine.
Above monarch drug, ministerial drug, adjuvant drug, make medicine mutually warm, promote to there is good invigorating the spleen and regulating the stomach, to change the stagnant effect helping digestion mutually, dyspepsia, inappetence and infantile anorexia are all had to good therapeutic effect.
Second object of the present invention is to provide a kind of method of preparing the pharmaceutical preparation of dyspepsia and intestinal stasis relieving, and the method craft science is reasonable, can better retain effective ingredient, the pharmaceutical preparation taking convenience making.
The present invention realizes the technical scheme that its second goal of the invention adopt: a kind of method of preparing the pharmaceutical preparation of dyspepsia and intestinal stasis relieving, is characterized in that:
A, by the Massa Medicata Fermentata of described proportioning, with 50-70 ℃ of water of 5-10 times of volume, carry out percolation, collect percolate, the concentrated clear paste that to obtain;
The water that adds equal volume amounts in B, the clear paste that obtains to steps A, stirs evenly, standing 12-36 hour, sucking filtration, the concentrated clear paste that to obtain of filtrate;
The water that adds equal volume amounts in C, the clear paste that obtains to step B, stirs evenly, standing 12-36 hour, sucking filtration, the concentrated clear paste that to obtain of filtrate;
D, the Radix Codonopsis of getting described proportioning, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei, Fructus Crataegi (parched), Radix Platycodonis, Fructus Hordei Germinatus (parched), Radix Glycyrrhizae mix, and the decocting that adds 5-12 times of volume boils 1-3 time, each 0.5-1.5 hour, and collecting decoction, filters, and concentrates to obtain clear paste;
In E, the clear paste that obtains to step D, add ethanol to reaching 70% containing alcohol amount, stir evenly, standing 12-36 hour, filters, and reclaims ethanol, the concentrated clear paste that to obtain;
F, the clear paste that step C and step e are obtained merge, and carry out preparation, obtain.
Above method is extracted the Massa Medicata Fermentata of process of preparing Chinese medicine effective ingredient by percolation method, the effective ingredient extracting by decoction with other herbal raw materials again merges, and can better retain various middle the effective elements of the medicines, and make it well mutually warm, promote mutually its good effect; And make modern medicines dosage form, taking convenience.
Following experiment also proves, Massa Medicata Fermentata ingredient extracting method of the present invention effectively, safety, and be convenient to merge with other drug composition:
After Massa Medicata Fermentata percolate is standing, there is layering, cannot merge with other drug composition.Applicant finds, can adopt twice above elimination lamination of water precipitating operation (operation of step B, C), and be convenient to merge with other drug composition.Be about to percolate and be concentrated into relative density 1.08～1.12(50 ℃) clear paste, the water gaging, standing 12-36 hour, sucking filtration such as add.And water precipitating number of times is compared, the results are shown in following table.
The comparison of water precipitating number of times
Result shows, water precipitating just can make Massa Medicata Fermentata percolate clear and bright 2 times above.Therefore, water precipitating can make the uniform clear paste of composition for 2 times, and the clear paste of being convenient to decoct after extracting with other drug merges, thereby can better retain the effective ingredient of various medicines, makes the pharmaceutical dosage form of being convenient to take.
Following zoopery proves, medicine of the present invention has the function of good dyspepsia and intestinal stasis relieving to the intestines and stomach:
Laboratory animal: Kunming mouse, male and female half and half, body weight 18～20g, adaptability is raised three days, the full-valence pellet feed of freely ingesting, Animal House temperature maintains 18～25 ℃ of left and right.SD rat, male and female half and half, body weight 180～200g, adaptability is raised three days, the full-valence pellet feed of freely ingesting.
(1) impact of and intestinal propulsion emptying on normal Mouse Stomach
Get Kunming mouse, according to body weight grouping, 10 every group, be respectively blank group, positive drug (metoclopramide) group, the high, medium and low dosage group of optimizing prescriptions oral liquid.
Blank group gives equal-volume distilled water, and metoclopramide group is made into 1mg/mL concentration by metoclopramide.Be fixed on same time administration every day, continue medication 3.Before last administration, fasting is 18 hours.Last administration finished after 40 minutes, carried out the semi-solid gavage of sticking with paste of trophism, and every mice gives 0.4mL/10g solid pastes, and solid pastes gavage after 20 minutes is put to death the de-neck of mice, and dissection is drawn materials.
Get before stomach pylorus and cardia ligation, get stomach, with filter paper, dry rear title full weight, then along greater gastric curvature, cut off body of stomach, dry title net weight after washing away gastric content.The difference of stomach full weight stomach function regulating net weight of take is gastric residue weight, calculates gastric residue and accounts for rope to fill with the percentage ratio of semi-solid weight of sticking with paste be gastric residual rate.
Get pylorus to the small intestinal of ileocecus, put into formalin solution, taking out is directly laid on blank sheet of paper gently, measure pylorus to ileocecus total length and pylorus and to black solid, stick with paste the distance in forward position, the distance that pylorus to the black semisolid of take is stuck with paste forward position accounts for that pylorus carries out small intestinal length to the percentage rate of ileocecus total length as intestinal propulsion rate and solid pastes advances measurement of length, carries out the mensuration of intestinal propulsion function.
The impact emptying on normal Mouse Stomach and intestinal propulsion suppresses
，Ben product senior middle school low dose group all can promote normal mouse gastric emptying and intestinal to advance as can be seen here.
(2) on atropine sulfate induced mice gastric emptying and the slow impact of intestinal propulsion
Get Kunming mouse, according to body weight grouping, 10 every group, be respectively blank group, positive drug (metoclopramide) group, model group, the high, medium and low dosage group of optimizing prescriptions oral liquid.
Blank group gives equal-volume distilled water, and model group gives equal-volume distilled water, and metoclopramide group is made into 1mg/mL concentration by metoclopramide, and every mice, according to body weight 0.1mL/10g, is fixed on same time administration every day, continues medication 3.After last administration 20 minutes, except Normal group, each organized mouse subcutaneous injection atropine sulfate (2mg/kg).After 20 minutes, give semi-solid paste, get harmonization of the stomach small intestinal and survey gastric residual rate and intestinal propulsion rate.
On the Mouse Stomach due to atropine sulfate, emptying and intestinal advances slow impact
As can be seen here, the high, normal, basic dosage of this product all can increase atropine sulfate in various degree due to gastric emptying and intestinal advance the gastric emptying of slow mice and intestinal to advance.
The description of test pharmaceutical preparation of the present invention of (1), (2) has good the intestines and stomach intestinal stasis relieving effect above.
(3) impact on rat gastric secretion
Get experimental rat, according to body weight grouping, 10 every group, be respectively blank group, positive drug (prepulsid) group, the high, medium and low dosage group of optimizing prescriptions oral liquid.
Blank group gives equal-volume normal saline, and prepulsid group is made into 0.14mg/mL concentration by cisapride.Be fixed on same time administration every day, continue medication 7.Rat fasting be can't help water 24 hours, and 3% pentobarbital sodium intraperitoneal anesthesia 0.5mL/100g, after rat anesthesia, cuts off osculum along abdomen median line, ligation pylorus, then by duodenal administration once, sew up incision of abdominal wall.After 2 hours, take out stitches and open abdominal cavity ligation cardia, win full stomach, with filter paper, dry bloodstain, along large curved side, cut off gastral cavity, incline and gastric content, be collected in graduated centrifuge tube, record gastric juice amount, with wide spectrum pH reagent paper, survey gastric content pH value.
Impact on rat gastric acid amount, gastric juice pH
As can be seen here, this product high dose group is the most obvious on gastric secretion and gastric juice pH impact.Also, pharmaceutical preparation of the present invention has good dyspepsia and intestinal stasis relieving effect.
The clear paste that when clear paste of above-mentioned steps A is 50 ℃, relative density is 1.08～1.12; The clear paste that when clear paste of described step B is 50 ℃, relative density is 1.08～1.12; The clear paste that when clear paste of described step C is 50 ℃, relative density is 1.08～1.12; The clear paste that when clear paste of described step D is 50 ℃, relative density is 1.12～1.18; The clear paste that when clear paste of described step e is 50 ℃, relative density is 1.08～1.12.
The dosage form that in above-mentioned steps F, preparation obtains is: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.
The clear paste in above-mentioned step F, step C and step e being obtained merges, and the specific practice of carrying out preparation is: the clear paste merging is centrifugal, and standing 24 hours, sucking filtration, filtrate is concentrated, and standing 24 hours, then sucking filtration, add sucrose 160.5g, sorbic acid 10.7g, adjusts total amount to 1000mL, sterilizing, be embedding, obtain oral liquid.
Dosage form is oral liquid, has avoided the moisture absorption of granule, softening, caking; Oral liquid taking convenience, bioavailability is high, in the oral liquid of being everlasting, adds correctives, and aromatic makes mouthfeel good, and gas fragrance is easily especially child's acceptance of patient.
According to the appearance character of the stability of oral liquid and oral liquid, abnormal smells from the patient, mouthfeel, working condition and cost screen additives:
(1) screening of solubilizing agent is because this oral liquid has adopted precipitate with ethanol and water precipitating technique, clear and bright, therefore no longer select solubilizing agent
(2) the screening oral liquid of sweeting agent should have deliciously, and the feature of easily accepting for patient, for regulating the mouthfeel of this product, has selected stevioside, sucrose, cyclamate and protein sugar to be made into respectively variable concentrations and compared, and the results are shown in following table.
The screening comparative result of sweeting agent
+ show better; ++ express friendship; +++ show fine
Result shows, selects sucrose, both can improve the taste of oral liquid, and appearance character do not change, and can strengthen system stability again; From cost factor, consider, select 15% sucrose.
(3) the screening oral liquid of antiseptic is half sterile preparation, and packing is to carry out under half aseptic condition.In order to guarantee the quality of preparation, prevent microbial growth breeding, can add antiseptic.And the kind to antiseptic, consumption has carried out screening test.The results are shown in following table.
The comparative test result of antiseptic
Result shows with sorbic acid and sodium benzoate better, considers the antiseptic effect of sorbic acid and sodium benzoate, selects sorbic acid as antiseptic, and consumption is 0.1%.
Concrete embodiment
Embodiment mono-:
A kind of specific embodiment of the present invention is, a pharmaceutical preparation for dyspepsia and intestinal stasis relieving, the composition of its medicine material and proportioning are: claim standby Radix Codonopsis 150g, Rhizoma Atractylodis 120g, Rhizoma Atractylodis Macrocephalae 150g, Radix Et Rhizoma Rhei 80g, Fructus Crataegi (parched) 150g, Massa Medicata Fermentata 150g, Radix Platycodonis 60g, Fructus Hordei Germinatus (parched) 150g, Radix Glycyrrhizae 60g.
The method of the pharmaceutical preparation of the dyspepsia and intestinal stasis relieving that preparation is described, its concrete steps are as follows:
A, by the Massa Medicata Fermentata of described proportioning, with 60 ℃ of water of 7 times of volumes, carry out percolation, collect percolate, the clear paste that in the time of concentrated 50 ℃, relative density is 1.08;
The water that adds equal volume amounts in B, the clear paste that obtains to steps A, stirs evenly, standing 24 hours, sucking filtration, filtrate concentrated the clear paste that relative density is 1.08 50 ℃ time;
The water that adds equal volume amounts in C, the clear paste that obtains to step B, stirs evenly, standing 24 hours, sucking filtration, filtrate concentrated the clear paste that relative density is 1.08 50 ℃ time;
D, the Radix Codonopsis of getting described proportioning, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei, Fructus Crataegi (parched), Radix Platycodonis, Fructus Hordei Germinatus (parched), Radix Glycyrrhizae, the decocting that adds respectively 10,8,6 times of volumes boils 3 times, and each 1 hour, collecting decoction, filter the clear paste that in the time of concentrated 50 ℃, relative density is 1.12;
In E, the clear paste that obtains to step D, add ethanol to reaching 70% containing alcohol amount, stir evenly, standing 24 hours, filter, reclaim ethanol, the clear paste that in the time of concentrated 50 ℃, relative density is 1.08;
F, the clear paste that step C and step e are obtained merge.Centrifugal, standing 24 hours, sucking filtration, filtrate is concentrated, and standing 24 hours, then sucking filtration, adding sucrose 160.5g, sorbic acid 10.7g, adjusts total amount to 1000mL, embedding, sterilizing, obtains oral liquid.
Embodiment bis-:
A kind of specific embodiment of the present invention is, a pharmaceutical preparation for dyspepsia and intestinal stasis relieving, the composition of its medicine material and proportioning are: claim standby Radix Codonopsis 120g, Rhizoma Atractylodis 100g, Rhizoma Atractylodis Macrocephalae 120g, Radix Et Rhizoma Rhei 50g, Fructus Crataegi (parched) 120g, Massa Medicata Fermentata 120g, Radix Platycodonis 30g, Fructus Hordei Germinatus (parched) 120g, Radix Glycyrrhizae 30g.
The method of the pharmaceutical preparation of the dyspepsia and intestinal stasis relieving that preparation is described, its concrete steps are as follows:
A, by the Massa Medicata Fermentata of described proportioning, with 50 ℃ of water of 5 times of volumes, carry out percolation, collect percolate, during 50 ℃ of concentrated relative densities, be 1.12 clear paste;
The water that adds equal volume amounts in B, the clear paste that obtains to steps A, stirs evenly, and standing 12 hours, sucking filtration, filtrate is so concentrated that to be 1.12 clear paste during 50 ℃ of relative densities;
The water that adds equal volume amounts in C, the clear paste that obtains to step B, stirs evenly, and standing 12 hours, sucking filtration, filtrate is so concentrated that to be 1.12 clear paste during 50 ℃ of relative densities;
D, the Radix Codonopsis of getting described proportioning, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei, Fructus Crataegi (parched), Radix Platycodonis, Fructus Hordei Germinatus (parched), Radix Glycyrrhizae, the decocting that adds 5 times of volumes boils 0.5 hour, and collecting decoction filters, and is 1.18 clear paste during 50 ℃ of concentrated relative densities;
In E, the clear paste that obtains to step D, add ethanol to reaching 70% containing alcohol amount, stir evenly, standing 12 hours, filter, reclaim ethanol, during 50 ℃ of concentrated relative densities, be 1.12 clear paste;
F, the clear paste that step C and step e are obtained merge, and according to the preparation process preparation of granule, obtain granule.
Embodiment tri-:
A kind of specific embodiment of the present invention is, a pharmaceutical preparation for dyspepsia and intestinal stasis relieving, the composition of its medicine material and proportioning are: claim standby Radix Codonopsis 180g, Rhizoma Atractylodis 150g, Rhizoma Atractylodis Macrocephalae 180g, Radix Et Rhizoma Rhei 100g, Fructus Crataegi (parched) 180g, Massa Medicata Fermentata 180g, Radix Platycodonis 80g, Fructus Hordei Germinatus (parched) 180g, Radix Glycyrrhizae 80g.
The method of the pharmaceutical preparation of the dyspepsia and intestinal stasis relieving that preparation is described, its concrete steps are as follows:
A, by the Massa Medicata Fermentata of described proportioning, with 70 ℃ of water of 10 times of volumes, carry out percolation, collect percolate, during 50 ℃ of concentrated relative densities, be 1.09 clear paste;
The water that adds equal volume amounts in B, the clear paste that obtains to steps A, stirs evenly, and standing 36 hours, sucking filtration, filtrate is so concentrated that to be 1.11 clear paste during 50 ℃ of relative densities;
The water that adds equal volume amounts in C, the clear paste that obtains to step B, stirs evenly, and standing 36 hours, sucking filtration, filtrate is so concentrated that to be 1.09 clear paste during 50 ℃ of relative densities;
D, the Radix Codonopsis of getting described proportioning, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei, Fructus Crataegi (parched), Radix Platycodonis, Fructus Hordei Germinatus (parched), Radix Glycyrrhizae, the decocting that adds 12 times of volumes boils 3 times, and each 1.5 hours, collecting decoction, filtered, and was 1.15 clear paste during 50 ℃ of concentrated relative densities;
In E, the clear paste that obtains to step D, add ethanol to reaching 70% containing alcohol amount, stir evenly, standing 36 hours, filter, reclaim ethanol, during 50 ℃ of concentrated relative densities, be 1.09 clear paste;
F, the clear paste that step C and step e are obtained merge, and according to the preparation process preparation of tablet, obtain tablet.
Embodiment tetra-:
A kind of specific embodiment of the present invention is, a pharmaceutical preparation for dyspepsia and intestinal stasis relieving, the composition of its medicine material and proportioning are: Radix Codonopsis 170g, Rhizoma Atractylodis 140g, Rhizoma Atractylodis Macrocephalae 125g, Radix Et Rhizoma Rhei 60g, Fructus Crataegi (parched) 160g, Massa Medicata Fermentata 140g, Radix Platycodonis 40g, Fructus Hordei Germinatus (parched) 165g, Radix Glycyrrhizae 35g.
The method of the pharmaceutical preparation of the dyspepsia and intestinal stasis relieving that preparation is described, its concrete steps are as follows:
A, by the Massa Medicata Fermentata of described proportioning, with 55 ℃ of water of 6 times of volumes, carry out percolation, collect percolate, the concentrated clear paste that to obtain;
The water that adds equal volume amounts in B, the clear paste that obtains to steps A, stirs evenly, and standing 24 hours, sucking filtration, the concentrated clear paste that to obtain of filtrate;
The water that adds equal volume amounts in C, the clear paste that obtains to step B, stirs evenly, and standing 24 hours, sucking filtration, the concentrated clear paste that to obtain of filtrate;
D, the Radix Codonopsis of getting described proportioning, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei, Fructus Crataegi (parched), Radix Platycodonis, Fructus Hordei Germinatus (parched), Radix Glycyrrhizae, the decocting that adds 6 times of volumes boils 2 times, and each 1 hour, collecting decoction, filtered, and concentrates to obtain clear paste;
In E, the clear paste that obtains to step D, add ethanol to reaching 70% containing alcohol amount, stir evenly, standing 24 hours, filter, reclaim ethanol, the concentrated clear paste that to obtain;
F, the clear paste that step C and step e are obtained merge, and according to the preparation process preparation of pill, obtain pill.
The preparation process of the present invention in step F also can adopt existing other preparation process, as: dispersible tablet, capsule, soft capsule,, the preparation process such as powder, drop pill, gel, with prepare corresponding dispersible tablet, capsule, soft capsule,, the dosage form such as powder, drop pill, gel.
Claims (5)
1. a pharmaceutical preparation for dyspepsia and intestinal stasis relieving, is made by following methods:
The composition of medicine material and proportioning are: Radix Codonopsis 120-180g, Rhizoma Atractylodis 100-150g, Rhizoma Atractylodis Macrocephalae 120-180g, Radix Et Rhizoma Rhei 50-100g, Fructus Crataegi (parched) 120-180g, Massa Medicata Fermentata 120-180g, Radix Platycodonis 30-80g, Fructus Hordei Germinatus (parched) 120-180g, Radix Glycyrrhizae 30-80g;
Its preparation process is: A, by the Massa Medicata Fermentata of described proportioning, with 50-70 ℃ of water of 5-10 times of volume, carry out percolation, and collect percolate, the concentrated clear paste that to obtain;
The water that adds equal volume amounts in B, the clear paste that obtains to steps A, stirs evenly, standing 12-36 hour, sucking filtration, the concentrated clear paste that to obtain of filtrate;
The water that adds equal volume amounts in C, the clear paste that obtains to step B, stirs evenly, standing 12-36 hour, sucking filtration, the concentrated clear paste that to obtain of filtrate;
D, the Radix Codonopsis of getting described proportioning, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Rhei, Fructus Crataegi (parched), Radix Platycodonis, Fructus Hordei Germinatus (parched), Radix Glycyrrhizae mix, and the decocting that adds 5-12 times of volume boils 1-3 time, each 0.5-1.5 hour, and collecting decoction, filters, and concentrates to obtain clear paste;
In E, the clear paste that obtains to step D, add ethanol to reaching 70% containing alcohol amount, stir evenly, standing 12-36 hour, filters, and reclaims ethanol, the concentrated clear paste that to obtain;
F, the clear paste that step C and step e are obtained merge, and carry out preparation, obtain.
2. the pharmaceutical preparation of a kind of dyspepsia and intestinal stasis relieving according to claim 1, it is characterized in that, the proportioning of described medicine material is: Radix Codonopsis 150g, Rhizoma Atractylodis 120g, Rhizoma Atractylodis Macrocephalae 150g, Radix Et Rhizoma Rhei 80g, Fructus Crataegi (parched) 150g, Massa Medicata Fermentata 150g, Radix Platycodonis 60g, Fructus Hordei Germinatus (parched) 150g, Radix Glycyrrhizae 60g.
3. the pharmaceutical preparation of dyspepsia and intestinal stasis relieving according to claim 1, is characterized in that: the clear paste that when clear paste of described steps A is 50 ℃, relative density is 1.08～1.12; The clear paste that when clear paste of described step B is 50 ℃, relative density is 1.08～1.12; The clear paste that when clear paste of described step C is 50 ℃, relative density is 1.08～1.12; The clear paste that when clear paste of described step D is 50 ℃, relative density is 1.12～1.18; The clear paste that when clear paste of described step e is 50 ℃, relative density is 1.08～1.12.
4. the pharmaceutical preparation of dyspepsia and intestinal stasis relieving according to claim 1, is characterized in that, the dosage form that in described step F, preparation obtains is: tablet, capsule, granule, pill, powder, gel, oral liquid formulations.
5. the pharmaceutical preparation of dyspepsia and intestinal stasis relieving according to claim 1, is characterized in that, the clear paste in described step F, step C and step e being obtained merges, the specific practice of carrying out preparation is: the clear paste merging is centrifugal, and standing 24 hours, sucking filtration, filtrate is concentrated, and standing 24 hours, then sucking filtration, add sucrose 160.5g, sorbic acid 10.7g, adjusts total amount to 1000mL, sterilizing, be embedding, obtain oral liquid.
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| CN201210107913.4A CN102614426B (en) | 2012-04-13 | 2012-04-13 | Medicinal preparation for helping digestion and removing stagnation |
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| CN201210107913.4A CN102614426B (en) | 2012-04-13 | 2012-04-13 | Medicinal preparation for helping digestion and removing stagnation |
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| CN110548117A (en) * | 2019-10-12 | 2019-12-10 | 吉林长白山药业集团股份有限公司 | Traditional Chinese medicine syrup capable of improving immunity of children |
| CN115089671B (en) * | 2022-06-09 | 2023-07-28 | 四川省畜牧科学研究院 | Traditional Chinese medicine preparation for preventing and treating goat digestive tract helminthiasis and preparation method thereof |
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| CN1745794A (en) * | 2004-09-08 | 2006-03-15 | 史钦荣 | Compound Chinese medicine for treating hypopepsia |
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| CN1745794A (en) * | 2004-09-08 | 2006-03-15 | 史钦荣 | Compound Chinese medicine for treating hypopepsia |
Non-Patent Citations (2)
| Title |
|---|
| 刘汉清主编.药剂学.《中药药剂学》.中国医药科技出版社,2001,全文. * |
| 国家药典委员会编.药典.《中华人民共和国药典》.化学工业出版社,2005,567-568. * |
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