CN103181559A - Nutritious food with bowel nourishing and purgation functions and preparation method thereof - Google Patents
Nutritious food with bowel nourishing and purgation functions and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a nutritious food with bowel nourishing and purgation functions and a preparation method thereof and belongs to the field of functional food. The nutritious food with the bowel nourishing and purgation functions is prepared by the following raw materials, which can be used as food and medicine, in part by weight: 3-10 parts of acanthopanax sessiliflorus seem, 2-5 parts of semen cassiae torae, 1-3 parts of radix polygonati officinalis, 1-5 part of semen torreyae, 2-6 parts of haw, 3-5 parts of mulberry, 1-5 parts of lily and 1-5 parts of semen cannabis. Proved and shown by animal and human body experiments, the nutritious food has remarkable bowel nourishing and purgation functions, and meanwhile can enhance immunity, is suitable for people needing bowel nourishing and having low immunity, but is not suitable for children.
Description
Technical field:
The present invention relates to nutraceutical that has function of relaxing bowel and preparation method thereof, belong to field of functional food.
Background technology
Constipation is not independently disease or a syndrome, but by the common symptom due to the Different types of etiopathogenises, it is slow to refer to that intestinal contents moves in intestines, and defecation frequency reduces, and ight soil is dry and hard, hard, amount is few, difficult defecation.Normal person's defecation varies with each individual, general every day first and second or per 2～3d defecation once, average every day stool weight 35～225g.The amount number of times of defecation often is subjected to food species and Effect of Environmental.
Functional consitipation can be divided into colon slow-remove type and outlet obstructed two types according to its pathological change.Major part belongs to the total colectomy transmission slowly in the Patients with Colonic Slow Transit Constipation.The intestines electrical activity studies show that colon advances frequency deceleration and duration to shorten to this kind of constipation patient reaching after the meal on an empty stomach.Sigmoid colon intestines wall is starkly lower than the normal person to the maximal tolerance dose of intestinal contents.Because intestinal contents is by slow, the full speed of rectum slows down, and causes the slow in reacting of rectum.Most scholars think that the neural pathological change of colon is the main cause that causes colon to transmit slowly.Discover that this kind of patient's colonic smooth muscle is starkly lower than the normal person to the post-stimulatory contractile response of acetylcholine, and is better than the normal person for adrenergic relaxation response, shows that the cholinergic nerve of arranging smooth muscle obviously reduces for one of Tomita.Recently there is the colon of discovery slow-remove type patient colon wall neuron to have the obvious apoptosis phenomenon to take place.Outlet obstructed type constipation is one group of polyphyly obstacle.Can be Anismus at the bottom of the idiopathic basin, Hirschsprung's disease, also can be to be secondary to childbirth, Overexertion defecation infringement sacral nerve and anal sphincter, and rectum is outstanding, degradation anatomic abnormalities under the prolapse of rectum and the perineum, and wherein Anismus more at the bottom of the basin sees.In the defecation process, striated muscle mainly is that puborectalis and external sphincter muscle of anus can not relax at the bottom of the basin, even abnormal contraction occurs, causes the rectum anal tube angle to become sharp, and anal tube pressure rises, and ight soil is discharged difficulty.The perineum drop syndrome may be because long-term Overexertion defecation, makes flesh weakness at the bottom of the basin, and ano-rectal angle is dwindled, and long-term tractive has a strong impact on the nerve conduction function.Recently there are some researches show this kind of constipation also can by musculus sphincter ani internus lose relax due to, cause the anal tube diastole bad, ight soil is detained rectum, causes difficult defecation.There is just anticipate threshold value and rectum maximal tolerance dose of report chronic constipation patient rectum obviously to increase than the normal person, show that internal organ kinesitherapy nerve and capacity affective neuron are impaired, it is blunt to the capacity IR to cause rectum, rectal sensation hypofunction, for want of just meaning and can not start defecation reflex.Often ignore just meaning, untimely defecation or do not form regularly bowl evacuation habit can make rectum that stimulation is lost normal sensitiveness.Because ight soil holdup time in large intestine is long, moisture absorption is too much, becomes stiff, causes constipation simultaneously.For the constipation of organic diseases such as non-enteron aisle is narrow and the constipation that non-spastic colon contraction causes, all can take edible food with functions of loosening bowel relieving constipation, cultivate on time that the methods such as custom of defecation solve.Because well-known, if take Western medicine when relaxing bowel, can cause nausea, bad reactions such as abdominal distension, diarrhoea and functional lesion.
In view of this situation that can cause side effect when relaxing bowel of Western medicine, and it is very slow to have the food effect of functions of loosening bowel relieving constipation, and seeking the new Chinese medicine nutraceutical that effectively relaxes bowel becomes when previous important problem.Therefore, people exist a large amount of demands to better effects if, that have no side effect and have the nutraceutical of function of relaxing bowel.
Summary of the invention
At the defective in the above-mentioned field, the invention provides a kind of more efficiently, nutraceutical with function of relaxing bowel, the composition of its prescription all is the medicine and food raw materials that nutraceutical is produced that can be used for through state food and Drug Administration's approval, the theory standard that meets integration of drinking and medicinal herbs fully is a kind of green nourishing food.
Another object of the present invention has provided the nutrient food preparation with function of relaxing bowel.
1, the nutraceutical that has function of relaxing bowel, its active component is mainly made by following medicine and food raw materials in portion by weight: Sessileflower Acanthopanax Bark tea 3-10 part, cassia seed 2-5 part, radix polygonati officinalis 1-3 part, Chinese torreyanut 1-5 part, hawthorn 2-6 part, mulberry fruit 3-5 part.
2, described nutraceutical, the weight portion of its medicine and food raw materials is preferably: 5 parts of Sessileflower Acanthopanax Bark tea, 3 parts of cassia seeds, 2 parts of radix polygonati officinalis, 1 part of Chinese torreyanut, 3 parts of hawthorn, 3 parts in mulberry fruit.
3, described nutraceutical also contains lily 1-5 part in the raw material, fructus cannabis 1-5 part.
4, described nutraceutical, its weight portion is preferably: 1 part of lily, 1 part of fructus cannabis.
5, described nutraceutical, the formulation of described nutraceutical are granule.
6, the preparation method of described nutraceutical comprises the steps:
1) take by weighing cassia seed, radix polygonati officinalis, Chinese torreyanut etc. 3 flavor raw materials in proportion, extract with 70% alcohol extract twice, merge the extract vacuum concentrated dry extract 1;
2) take by weighing Sessileflower Acanthopanax Bark tea, hawthorn, mulberry fruit etc. 3 flavor raw materials in proportion and extract 1 time with distilled water, with the extract vacuum concentrate dry extract 2;
3) take by weighing lily, fructus cannabis etc. 2 flavor raw materials in proportion, extract 1 time with distilled water, with the extract vacuum concentrate dry extract 3;
4) merge dry extract 1,2,3, it is ground into 200 order powder, be active component of the present invention, be prepared into granule according to a conventional method.
8, also need are following dry 3 hours at 50-60 ℃ for the dry extract that obtains after described the concentrating.
9, the prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, electuary, tablet, capsule, oral liquid etc.
The modern Chinese medicine theory thinks that constipation can the former thereby formation because of life at ordinary times, diet, bowl evacuation habit etc.The main interpretation of the cause, onset and process of an illness is deficiency of both vital energy and Yin or dryness-heat stagnating in the interior, and internal organs gas is not smooth.Clinical condition sees that times of defecation reduces, the infrequent defecation time lengthening, and most of patients stool a few days delegation, person delegation on the seven or eight very, nonetheless, the patient who has still needs just be able to delegation by medicine; The patient who has, though stool is also normal blanking time, excrement matter drying is discharged difficulty; Though or excrement matter is not stiff, because deficient qi and blood, face the lavatory and exert and earn weakly, discharge endless.Clinical being also shown in except constipation more do not have other accompanying symptoms; Or because constipation and turbid Qifailing to descend causes abdominal distension even stomachache, dizzy alliteration, the vexed belch of gastral cavity, anorexia, sleep disorder, dysphoria etc.Card having holds concurrently assortedly, detailed to distinguish and to face card without doubt.
According to above-mentioned modern Chinese medicine theory, the nutraceutical with function of relaxing bowel disclosed by the invention, it mainly is to be prepared from according to a certain weight ratio with Sessileflower Acanthopanax Bark tea, cassia seed, lily, radix polygonati officinalis, Chinese torreyanut, hawthorn, fructus cannabis, mulberry fruit etc.
Sessileflower Acanthopanax Bark tea is the tea that Araliaceae machaka Sessileflower Acanthopanax Bark leaf is made, and Sessileflower Acanthopanax Bark and wilsonii are equal to be belonged to together.Thorn on Sessileflower Acanthopanax Bark stem, the branch seldom is bordering on stinglessly, is distributed in each mountain area on the south the Xiaoxinanlin Mountains, Heilongjiang Province.The Sessileflower Acanthopanax Bark branches and leaves are luxuriant, and flowers and fruits are unusual, except being a kind of viewing and admiring the tree, still are a kind of wild vegetable and important medicinal plant of keeping healthy.The pharmacological action of Sessileflower Acanthopanax Bark tea is multifarious, has strengthening by means of tonics, adjusts effects such as blood pressure, nerve, blood sugar and cholesterol.
Cassia seed is the mature seed of legume Cassia tora Cassia obtusifolia L. or little Cassia tora Cassia toral..Also name Cassia occidentalis (" Wu Pu Bencao ") etc.Bitter, sweet, cool in nature.Return liver, kidney channel.Function: clearing liver, make eye bright, sharp water defaecation.Cure mainly: wind-heat cute conjunctivitis, glaucoma, night blindness, hypertension, hepatitis, cirrhotic ascites, habitual constipation.
Lily, this product are the dry meat scaly leaf of liliaceous plant tiger lily, lily or Lilium tenuifolium.The Shennong's Herbal record " main perverse trend abdominal distension, pained.Sharp stool and urine, tonifying middle-Jiao and Qi.Flavor efficacy, sweet, little hardship of distinguishing the flavor of is slightly cold.The thoughts of returning home, lung channel.Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.Pharmacological action: this product water extract has strong, anti-anoxic, calmness and anti-allergic effects.Contained colchicin tool estrogen-like action can resist cancer cell mitosis, stops the propagation of cancer cell.
Radix polygonati officinalis, this product are the dry rhizome of liliaceous plant radix polygonati officinalis.Have another name called luxuriant, luxuriant, Wei ginseng." main apoplexy sudden-heat can not shake, and falls muscle knot meat, various symptims and signs of deficiency in the Shennong's Herbal record." " book on Chinese herbal medicine justice " record " radix polygonati officinalis, the sweet greasiness of distinguishing the flavor of, soft and moist product.It is scorching that the lung stomach is controlled in modern thought, and body fluid dries up, and thirsty choke is done and waited disease, and exuberance of stomach fire, the dry paddy that disappears yearningly, the polyorexia person has especially very and imitates." gas is little, it is sweet to distinguish the flavor of, and that chews must stick.Flavor efficacy, it is sweet to distinguish the flavor of, and property is flat.Attach to the lung and stomach meridians.Nourishing Yin and moistening lung, nourishing the stomach to improve the production of body fluid.
Chinese torreyanut, this product are the dry mature seed of Chinese yew Chinese torreya.Its tree has another name called " wild China fir " as China fir.This product can tempting appetite.Flavor efficacy is sweet, and is flat.Return lung, stomach, large intestine channel.Killing insect and eliminating accumulation, moistening dryness for relaxing bowels.Pharmacological action: clinical practice is in hookworm, roundworm, taeniasis, abdominal pain due to enterositosis, infantile malnutrition, constipation.
Hawthorn is the fruit of rosaceous plant hawthorn Crataegus pinnatifida Bge. or fructus crataegi cuneatae.Also haw (" 101 choosing side ") in the famous mountain.Main component is organic acid and flavone compound.The traditional Chinese medical science is according to flavor acid, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Function: long-pending, diffusing extravasated blood, expelling tenia help digestion.Cure mainly: meat Ji, Disorder lump in the abdomen, phlegm and retained fluid, ruffian are full, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia, generation postpartum abdominal pain, lochiorrhagia, children's's breast food and stagnate.
Fructus cannabis is the ripening fruits of 1 year living plant hemp Cannabis sativa L. of Moraceae.Also name pockmarks benevolence (treatise on Febrile Diseases), cannabis,fructus (" property of medicine opinion "), winter pockmarks (" dietitian's heart mirror ").It is sweet to distinguish the flavor of, and property is flat.Return spleen, stomach, large intestine channel.Function: moisturize, laxation, treating stranguria, invigorate blood circulation.Cure mainly: the dry constipation of intestines, quench one's thirst, hot pouring, wandering arthritis, dysentery, irregular menstruation, scabies, tinea leprosy.Bowel relaxing functions: appoint Hanyang to find that a fructus cannabis is traditional Chinese medicine simply, has the effect that relaxes bowel, nourishes qi-restoratives.Modern medicine has proved that its contained fat oil has lubricated intestines wall, the effect of softening stool, slight excited intestinal tube, increase wriggling, the big intestinal absorption moisture of minimizing.
Mulberry fruit is the dry fruit ear of moraceae plants mulberry Moruxs alba L..Extract main component is rutin, carrotene, vitamin A, B, C, protein, fat oil, volatile oil, tannin, inorganic salts etc.Also contain rutin sophorin, anthocyanin.Nature and flavor are sweet, sour, and are cold.The thoughts of returning home, liver, kidney channel.Function: the enriching yin of enriching blood, promote the production of body fluid and moisturize.Be used for dizzy tinnitus, palpitation and insomnia, poliosis, Tianjin wound is thirsty, and interior heat is quenched one's thirst, blood deficiency and constipation.
We are monarch drug in a prescription with medicine and food raw materials Sessileflower Acanthopanax Bark tea, beneficial lung yin, spleen-benefiting mind-tranquilizing, and tonifying middle-Jiao and Qi and detoxifcation relax bowel.This be because: Sessileflower Acanthopanax Bark tea major function has the effect that replenishes qi to invigorate the spleen, tonifies the kidney to relieve mental strain; Be ministerial drug with medicine and food raw materials cassia seed, lily, Chinese torreyanut, this be because: cassia seed, lily major function Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing; Chinese torreyanut major function killing insect and eliminating accumulation, moistening dryness for relaxing bowels; The moisturizing of natural plants hawthorn, fructus cannabis, laxation, treating stranguria, invigorate blood circulation; The enriching yin of enriching blood of mulberry fruit, promote the production of body fluid moisturize, relieving stagnant Qi, the ruffian of loosing, rush down phlegm, disappear long-pending, with the extract of these medicine and food raw materials seasoning matter as this prescription, again with radix polygonati officinalis for making material, bowl spares, moisturize, analgesic antidotal, thereby make the better effects if that relaxes bowel of this prescription, more comprehensively.
The used medicine of the present invention all adopts ethanol and the aqueous solution to extract, the temperature that refluxes is lower than 100 ℃, make active ingredient in the medicine be difficult for Yin Gaowen and change, when concentrated, adopt vacuum to concentrate simultaneously, make the active ingredient in the extract not be subjected to temperatures involved, avoid some destruction and loss to heat-labile active ingredient, preserved nutritional labeling and the fragrance of raw material better.The dry extract that obtains after concentrating need 50-60 ℃ dry 3 hours down, could finish-drying.
Experiment shows that nutraceutical of the present invention has tangible function of relaxing bowel through animal and human's body, can also strengthen immunity simultaneously, and being used for need the person of relaxing bowel and immunocompromised person.
Originally have nutritional food formula and products thereof the production technology of function of relaxing bowel, show nutraceutical effect of the present invention by testing example, test comprises function assessment test and security toxicology test.Specifically see the following examples and experimental example for details.
The prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, electuary, tablet, capsule, oral liquid etc., the present invention adopts the particle formulation, be because consider that modern's rhythm of life ratio is very fast, adopt the advantage of granule to be exactly: easy to carry, absorb rapidly, this is a kind of more modern modern preparation type that certain technology content is arranged.
The specific embodiment
Further set forth nutraceutical of the present invention with the test example by the following examples.
Embodiment 1
Feed proportioning: Sessileflower Acanthopanax Bark tea 5000g, cassia seed 3000g, lily 1000g, radix polygonati officinalis 1000g, Chinese torreyanut 1000g, hawthorn 3000g, fructus cannabis 1000g, mulberry fruit 3000g.
Its preparation method: according to claims and described nutrient food preparation of this specification, be prepared.
Embodiment 2
Feed proportioning: Sessileflower Acanthopanax Bark tea 10000g, cassia seed 6000g, lily 2000g, radix polygonati officinalis 2000g, Chinese torreyanut 2000g, hawthorn 6000g, fructus cannabis 2000g, mulberry fruit 6000g.
Its preparation method: according to claims and described nutrient food preparation of this specification, be prepared.
Embodiment 3
Feed proportioning: Sessileflower Acanthopanax Bark tea 15000g, cassia seed 9000g, lily 3000g, radix polygonati officinalis 3000g, Chinese torreyanut 3000g, hawthorn 9000g, fructus cannabis 3000g, mulberry fruit 9000g.
Its preparation method: according to claims and described nutrient food preparation of this specification, be prepared.
According to " health food check and assessment technique standard " (2003 editions) criterion to the function of relaxing bowel nutraceutical, show that through zoopery nutraceutical of the present invention has tangible function of relaxing bowel.
Experimental example
1. materials and methods
1.1 animal used as test
The Kunming kind secondary female mice that experiment selects for use Chinese Academy of Medical Sciences's animal center breeding field to provide, body weight 20～24g is divided into 5 groups of (certificates of competency: the moving word of doctor 01-3001 number) at random by body weight.
1.2 dosage selects to be tried thing (nutraceutical of the embodiment of the invention 1 preparation, down together) with adult's recommended amounts oral 720mg/d every day, by adult 60kg batheroom scale, i.e. 12mg/ (kg body weight).This nutraceutical is established 2.5g/ (kg body weight d), 3.3g/ (kg body weight d), three of 6.7g/ (kg body weight d) are tried mouse dosage.Establish normal control group and model control group (compound diphenoxylate group) simultaneously.Take administration by gavage, irritate stomach every day once, 0.2mL/ (kg body weight d) gives this nutraceutical 14d continuously, and normal control group and model control group are irritated stomach equivalent distilled water every day.
1.3 experimental technique
1.3.1 after the small intestine propulsion trial was tried thing 14d continuously, each organized mouse fasting 24h.Except the normal control group, all the other each groups are irritated stomach compound diphenoxylate 50mg/ (kg body weight d).Irritate stomach 15% black ink for behind the 20min each treated animal.Put to death animal with the cervical vertebra dislocation method behind the 20min, take out the whole section small intestine to caecum portion from pylorus immediately, do not add the traction tiling linearly.Measure the small intestine total length and by pylorus to the displacement of ink motion forward position, calculate small intestine propelling rate.
Small intestine propelling rate (%)=ink displacement (cm)/small intestine total length (cm) * 100%
1.3.2 after the test of mouse defecation was tried thing 14d continuously, each organized mouse fasting 24h.Except the normal control group, all the other each groups are irritated the stomach compound fragrant promise 10mg/ in ground (kg body weight d).Mouse is put into cage raise separately, normal drinking-water feed.Behind the 1h, irritate stomach 10% black ink thing that serves as a mark for each treated animal.Every mouse of observed and recorded is from irritating the stomach compound diphenoxylate to discharging the melena required time first, and mouse stool interval and defecation weight in the 8h.
Experimental data is added up with variance analysis.
2. experimental result
2.1 this nutraceutical sees Table 1 to the influence of mouse body weight
This nutraceutical of table 1 is to the influence of mouse body weight
By table 1 as seen, give at per os before and after this nutraceutical 14d of mouse various dose, compare with the normal control group, model control group and each dosage group body weight all do not have significant difference (P＞0.05).
2.2 this nutraceutical sees Table 2 to the influence of mouse small intestine ahead running
This nutraceutical of table 2 is to the influence of mouse small intestine propelling rate
* has compared highly significant difference (P＜0.01) with model control group.
* * has compared utmost point significant difference (P＜0.001) with model control group.
By table 2 as seen, before and after per os gave this nutraceutical 14d of mouse various dose, model control group was compared small intestine propelling rate and is reduced by 35% (P＜0.001) with the normal control group, showed that model sets up successfully.Compare with model control group, 2.5g/ (kg body weight d) group small intestine propelling rate improves 28% (P＜0.01), and 3.3g/ (kg body weight d) group small intestine propelling rate improves 47% (P＜0.001), and 6.7g/ (kg body weight d) group small intestine propelling rate improves 51% (P＜0.001).
2.3 this nutraceutical sees Table 3 to the influence of mouse defecation time
This nutraceutical of table 3 is to the influence of mouse defecation time
* compare with model control group that there were significant differences (P＜0.05).
* * has compared utmost point significant difference (P＜0.001) with model control group.
By table 3 as seen, before and after per os gave this nutraceutical 14d of mouse various dose, model control group was compared with the normal control group and is arranged melena time lengthening 154% (P＜0.001) first, showed that model sets up successfully.Compare with model control group, the dosage group is arranged the melena time first and is shortened 21 (P＜0.001) among the 3.3g/ (kg body weight d), and 6.7g/ (kg body weight d) group is arranged the melena time first and shortened 11% (P＜0.05).
2.4 this nutraceutical sees Table 4 to the influence of mouse stool interval
This nutraceutical of table 4 is to the influence of mouse stool interval
* compare with model control group that there were significant differences (P＜0.05).
* has compared utmost point significant difference (P＜0.01) with model control group.
By table 4 as seen, before and after per os gave this nutraceutical 14d of mouse various dose, model control group was compared the 8h stool interval and is reduced by 71% (P＜0.001) with the normal control group, showed that model sets up successfully.Compare with model control group, 3.3g/ (kg body weight d) increases by 26% (P＜0.05) than 8h stool interval, and all the other dosage group 8h stool interval all do not have significant difference (P＜0.05).
2.5 this nutraceutical sees Table 5 to the influence of mouse defecation weight
This nutraceutical of table 5 is to the influence of mouse defecation weight
* compare with model control group that there were significant differences (P＜0.05).
* has compared highly significant difference (P＜0.01) with model control group.
* * has compared utmost point significant difference (P＜0.001) with model control group.
Table 5 as seen, before and after per os gave this nutraceutical 14d of mouse various dose, model control group was compared 8h defecation weight and is reduced by 67% (P＜0.001) with the normal control group, showed that model sets up successfully.Compare with model control group, 3.3g/ (kg body weight d) increases by 41% (P＜0.05) than 8h defecation weight, and 6.7g/ (kg body weight d) group 8h defecation weight increases by 43% (P＜0.01).
3. conclusion
Behind this nutraceutical 14d, irritate the stomach compound diphenoxylate and cause mouse constipation model continuously.Compare with model control group, 2.5g/ (kg body weight d) group mouse small intestine propelling rate improves 28% (P＜0.01), arranges melena time, 8h stool interval, 8h defecation weight first and does not all have significant difference (P＞0.05).3.3g/ (kg body weight d) group mouse small intestine propelling rate improves 47% (P＜0.001), arranges the melena time first to shorten 21% (P＜0.001), the 8h stool interval increases by 26% (P＜0.05), and 8h defecation weight increases by 41% (P＜0.01).6.7g/ (kg body weight d) group mouse propelling rate improves 51% (P＜0.001), arranges the melena time first to shorten 11% (P＜0.05), 8h defecation weight increases by 43% (P＜0.01), and the 8h stool interval does not have significant difference (P＞0.05).Experimental data is added up with variance analysis.
According to " health food check and assessment technique standard " (2003 editions) criterion to the function of relaxing bowel nutraceutical, show that through zoopery nutraceutical of the present invention has tangible function of relaxing bowel.
The experiment of experimental example 2 human experiments
1. experimenter's selection defecation frequency reduces and ight soil hardness enhancer; Defecate and be less than the person week 3 times; There is not organic constipation person; Habitual constipation person.
2. the experimenter that should not participate in the experiment can not oral feeding or can not be taken the person that tried the thing in accordance with regulations; The unclear person of main suit;
Have a delicate constitution and to carry out the experimenter; Carry out operation in the 30d and caused constipation symptom generation person; Become the recent difficult defecation person (colon cancer, serious enteritis, intestines obstruct cloudy, IBD etc.) who causes because of serious structural disease.
Difficult defecation and with pain person; Acute enterogastric diseases person was taken place in the 30d; Pregnancy period and menstrual woman; Be associated with serious general disease patient such as cardiovascular, liver, kidney and hemopoietic system; Other accompanying diseases are arranged just the curer and take the article relevant with being tried function in a short time and have influence on judgement person to the result, all should get rid of.
3. experiment grouping
Be divided into test-meal group and control group at random by experimenter's constipation symptom (defecation frequency, ight soil proterties, DOS etc.), consider the principal element that influences the result such as age, sex, diet, constipation reason etc. as far as possible, carry out the harmony check, with the comparativity between the assurance group.Every group of experimenter's 20 examples.
4. tried dosage and the using method of thing (nutraceutical of the embodiment of the invention 2 preparations, together following)
The test-meal group is taken and is tried thing by recommendation instructions of taking, dose, adult's recommended amounts 720mg/d every day.By adult 60kg batheroom scale, i.e. 12mg/ (kg body weight).
Control group adopts blank.Carry out the test-meal experiment by blind method.Tried thing and give time 10d, experimental session does not change original eating habit, normal diet.
5. observation index
(1) safety indexes (before the experiment beginning, checking once)
General situation comprises spirit, sleep, diet, stool and urine, blood pressure etc.; Blood, urine, just routine inspection; Liver, kidney function test; Chest X-rays, electrocardiogram, Abdominal B type ultrasonography.
(2) effect index
Every day the experimenter is inquired and record, record the experimenter simultaneously and take the situation of being tried the preceding 6d of thing and testing when.Every day defecation frequency: the variation of defecation frequency before and after the record experimenter test-meal; Defecation condition: according to the difficult defecation degree; Diet situation: the ratio of cellulose family food; Record and have no adverse reaction (feel sick, flatulence, diarrhoea, stomachache and ight soil are unusual etc.).
6. experimental result is judged
Test-meal group and control group compare after the test-meal, and each has obvious improvement defecation frequency, defecation condition and ight soil proterties, and then difference has conspicuousness (seeing Table 6).Can judge the effect that thing (this nutraceutical) has defaecation that tried.
This nutraceutical of table 6 is to the influence of human body stool interval
By table 6 as seen, taking this nutraceutical 10d front and back, control group is compared the 8h stool interval with experimental group increase by 24% (P＜0.05), and therefore, this nutraceutical has function of relaxing bowel.
Safety indexes in 5 observation index of experimental example, when after experiment is finished, reexamining, situation about checking before the experiment beginning that all coexists, no significant difference.
Effect index in 5 observation index of experimental example, by the experimenter being inquired and records demonstration, experimenter's defecation condition every day is: taking this nutraceutical 10d front and back, experimental group is compared the 8h stool interval with control group increase by 24% (P＜0.05), and defecation is smooth and easy; Record shows that the diet situation is normal; Record shows and to have no adverse reaction (feel sick, flatulence, diarrhoea, stomachache and ight soil are unusual etc.).
According to " health food check and assessment technique standard " (2003 editions) criterion to the function of relaxing bowel nutraceutical, show that through human experimentation nutraceutical of the present invention has tangible function of relaxing bowel.
Claims (8)
1. the nutraceutical that has function of relaxing bowel, its active component is mainly made by following medicine and food raw materials in portion by weight: Sessileflower Acanthopanax Bark tea 3-10 part, cassia seed 2-5 part, radix polygonati officinalis 1-3 part, Chinese torreyanut 1-5 part, hawthorn 2-6 part, mulberry fruit 3-5 part.
2. nutraceutical according to claim 1, the weight portion of described medicine and food raw materials is preferably: 5 parts of Sessileflower Acanthopanax Bark tea, 3 parts of cassia seeds, 2 parts of radix polygonati officinalis, 1 part of Chinese torreyanut, 3 parts of hawthorn, 3 parts in mulberry fruit.
3. nutraceutical according to claim 1 also contains lily 1-5 part in the raw material, fructus cannabis 1-5 part.
4. nutraceutical according to claim 3, its weight portion is preferably: 1 part of lily, 1 part of fructus cannabis.
5. nutraceutical according to claim 1, the formulation of described nutraceutical is granule.
6. the preparation method of nutraceutical according to claim 1 comprises the steps:
1) take by weighing cassia seed, radix polygonati officinalis, Chinese torreyanut 3 flavor food and medicament dual-purpose raw materials in proportion, extract with 70% alcohol extract twice, merge the extract vacuum concentrated dry extract 1;
2) take by weighing Sessileflower Acanthopanax Bark tea, hawthorn, mulberry fruit 3 flavor food and medicament dual-purpose raw materials in proportion and extract 1 time with distilled water, with the extract vacuum concentrate dry extract 2;
3) take by weighing lily, fructus cannabis food and medicament dual-purpose raw material in proportion, extract 1 time with distilled water, with the extract vacuum concentrate dry extract 3;
4) merge dry extract 1,2,3, it is ground into 200 order powder, be active component of the present invention, be prepared into granule according to a conventional method.
7. also need are following dry 3 hours at 50-60 ℃ for the dry extract that obtains after described the concentrating.
8. the prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, electuary, tablet, capsule, oral liquid etc.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104600330A CN103181559A (en) | 2011-12-30 | 2011-12-30 | Nutritious food with bowel nourishing and purgation functions and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104600330A CN103181559A (en) | 2011-12-30 | 2011-12-30 | Nutritious food with bowel nourishing and purgation functions and preparation method thereof |
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| CN103181559A true CN103181559A (en) | 2013-07-03 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103431376A (en) * | 2013-07-18 | 2013-12-11 | 浙江劲膳美生物科技有限公司 | Special diet edible for constipation patients |
| CN105919133A (en) * | 2016-06-06 | 2016-09-07 | 惠州同富康生物科技有限公司 | Health food composition containing vatica mangachapoi and capable of smoothing intestine and relieving constipation and preparation method thereof |
| CN108477460A (en) * | 2018-04-18 | 2018-09-04 | 湖南喜玫瑰医药生物科技有限公司 | A kind of composition and preparation method thereof having effect of relaxing bowel |
-
2011
- 2011-12-30 CN CN2011104600330A patent/CN103181559A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103431376A (en) * | 2013-07-18 | 2013-12-11 | 浙江劲膳美生物科技有限公司 | Special diet edible for constipation patients |
| CN103431376B (en) * | 2013-07-18 | 2015-08-05 | 浙江劲膳美生物科技有限公司 | The special diet that a kind of constipation person eats |
| CN105919133A (en) * | 2016-06-06 | 2016-09-07 | 惠州同富康生物科技有限公司 | Health food composition containing vatica mangachapoi and capable of smoothing intestine and relieving constipation and preparation method thereof |
| CN108477460A (en) * | 2018-04-18 | 2018-09-04 | 湖南喜玫瑰医药生物科技有限公司 | A kind of composition and preparation method thereof having effect of relaxing bowel |
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Addressee: Dandong Jiajie Biological Technology Co., Ltd. Document name: Notification of Publication of the Application for Invention |
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Application publication date: 20130703 |