CN103816519A - Spleen-strengthening dampness-removing traditional Chinese medicine composition and preparation method thereof - Google Patents
Spleen-strengthening dampness-removing traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention provides a technical scheme of spleen-strengthening dampness-removing traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is prepared from active ingredients in parts by weight as follows: 250-350 parts of stir-fried largehead atractylodes rhizome, 250-350 parts of dried ginger, 80-120 parts of stir-fried rhizoma atractylodis, 80-120 parts of officinal magnolia bark, 80-120 parts of tangerine peel, 80-120 parts of rhizoma pinelliae preparata, 120-180 parts of coix seeds, 120-180 parts of poria, 80-120 parts of purified fructus amomi, 120-180 parts of raw hawthorn, 120-180 parts of raw malt and 80-120 parts of raw licorice. The preparation method comprises the steps as follows: extracting volatile oil from five medicines, namely, the stir-fried largehead atractylodes rhizome, the dried ginger, the stir-fried rhizoma atractylodis, the tangerine peel and the purified fructus amomi, and including the volatile oil with beta-cyclodextrin; adding water into decoction dregs and the rest seven medicines for decoction for two times, merging, filtering and concentrating decoction liquids, adding a volatile oil inclusion compound, dextrin and xylitol, evenly mixing the mixture, adding 70% of ethyl alcohol to produce softwood, and producing the softwood into a needed dosage form.
Description
Technical field
The invention belongs to medical technical field, relate to Chinese medicine composition of a kind of invigorating the spleen to clear away damp pathogen and preparation method thereof.
Background technology
Along with expanding economy, the raising of people's living standard, there are great changes in people's life style, and the people in subhealth state are also more and more.Subhealth state is that body yang blood and qi departs from balance, in the critical state of physiology body constitution and pathology body constitution.Pathologic body constitution is the material base of sub-health state, has reflected the inherent mechanism that subhealth state forms.Sub-health state is performance characteristic and the outer explicit form of pathology body constitution, and physical factors is the endogenous cause of ill that subhealth state occurs, and is also the inherence foundation that subhealth state pattern of syndrome forms.The conclusion that scholar makes the inquiry agency of people's constitution is in recent years as follows: human physique is divided into obscure matter, greasy stagnant matter, scorching matter, Chi Lengzhi, tired white light matter by professor Kuang Tiaoyuan.What makes people rich people's constitution typing as coordinating matter, imbalance matter, nervous matter, weak matter.The matter of wherein lacking of proper care is divided into again stasis matter and interior caloic, and weak matter is divided into again deficiency of vital energy matter, yang deficiency matter, damage of essence matter, body fluid deficiency matter, and stasis matter have again stagnation of liver-QI matter, phlegm-damp matter and stasis blocking matter point, deficiency of vital energy matter also have insufficiency of lung-QI, deficiency of spleen-QI and deficiency of heart-blood point.And sub-health state result is made to fuzzy cluster analysis, subhealth state colony mainly belongs to the said melancholia of the traditional Chinese medical science, phlegm-damp and deficiency syndrome three major types.
As can be seen here, for the residing sub-health state of pathologic body constitution person, can by its typing be from body constitution staff: spleen, the heart, lung, deficiency of liver-QI type, liver energy stagnation type, blood stasis blocking type, phlegm-damp type, interior-heat (excess-heat and deficiency-heat) type, yang deficiency of spleen and stomache.Phlegm-damp type in subhealth state is many to be caused by the reason such as a little less than diseases caused by exogenous pathogenic factor cold-damp, eating and drinking without temperance, deficiency of YANG QI, and especially not transport be the key of morbidity to spleen sun.The deficiency of vital energy can not promote blood, and hemorheology shows, and dense, glutinous, solidifying, stagnant blood stasis stagnation of phlegm sample changes, and expectorant is turbid, blood stasis is body pathology product, is again paathogenic factor.Function is low to be gathered and influences each other with pathologic product, acceleration aging or disease process.
Clinical observation is found, different constitutional typies and subhealth state are further development of a certain disease and have certain homoplasy, the pathological manifestations of improving body constitution is the preferred plan of prevention subhealth state, by the conditioning of body constitution, can prevent the generation of subhealth state, and can prevent its conversion to a certain disease, stop the development of subhealth state.Therefore nursing one's health body constitution is the effective means of intervening sub-health.But, the current Chinese medicine composition that does not also carry out intervening sub-health by conditioning body constitution.
Summary of the invention
Technical problem to be solved by this invention, be exactly for the existing deficiency of prior art, and provide a kind of draw materials easy, evident in efficacy, mouthfeel is good, the Chinese medicine composition of taking convenience, the invigorating the spleen to clear away damp pathogen that has no side effect is intervened and treats subhealth state, the present invention simultaneously also provides dosage form of this Chinese medicine composition and preparation method thereof.
This programme is achieved by the following technical measures:
The Chinese medicine composition of invigorating the spleen to clear away damp pathogen of the present invention, this Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Atractylodis Macrocephalae (parched) 250-350 part, Rhizoma Zingiberis 250-350 part, Rhizoma Atractylodis (parched) 80-120 part, Cortex Magnoliae Officinalis 80-120 part, Pericarpium Citri Reticulatae 80-120 part, Rhizoma Pinelliae 80-120 part, raw pearl barley 120-180 part, Poria 120-180 part, clean Fructus Amomi 80-120 part, Fructus Crataegi 120-180 part, Fructus Hordei Germinatus 120-180 part, Radix Glycyrrhizae 80-120 part.
Further improvement of the present invention is the Chinese medicine composition of this invigorating the spleen to clear away damp pathogen, and this Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Atractylodis Macrocephalae (parched) 280-320 part, Rhizoma Zingiberis 280-320 part, Rhizoma Atractylodis (parched) 90-110 part, Cortex Magnoliae Officinalis 90-110 part, Pericarpium Citri Reticulatae 90-110 part, Rhizoma Pinelliae 90-110 part, raw pearl barley 130-170 part, Poria 130-170 part, clean Fructus Amomi 90-110 part, Fructus Crataegi 130-170 part, Fructus Hordei Germinatus 130-170 part, Radix Glycyrrhizae 90-110 part.
Further improvement of the present invention is the Chinese medicine composition of this invigorating the spleen to clear away damp pathogen, is made up of the crude drug of following weight portion: 300 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 300 parts of Rhizoma Zingiberiss, 100 parts of Rhizoma Atractylodis (parched), 100 parts of Cortex Magnoliae Officinalis, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Rhizoma Pinelliae, 150 parts of raw pearl barleys, 150 parts, Poria, 100 parts of clean Fructus Amomis, 150 parts of Fructus Crataegi, 150 parts of Fructus Hordei Germinatus, 100 parts of Radix Glycyrrhizae.
Above-mentioned Chinese medicine composition is made following dosage form: granule, pill, tablet, capsule.
The preparation method of above-mentioned Chinese medicine composition, this preparation method comprises the steps: Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Zingiberis, Rhizoma Atractylodis (parched), Pericarpium Citri Reticulatae, clean Fructus Amomi five kinds of Chinese medicine to extract volatile oil, with beta-cyclodextrin inclusion compound, for subsequent use; Medicinal residues and Cortex Magnoliae Officinalis, Rhizoma Pinelliae, raw pearl barley, Poria, Fructus Crataegi, Fructus Hordei Germinatus, the Radix Glycyrrhizae of five kinds of Chinese medicine that extracts volatile oil decocts with water 2 times, and amount of water is drug weight 12 times for the first time, boils rear lasting decoction 1.5 hours; Amount of water is drug weight 8 times for the second time, continues to boil 1 hour after boiling, and collecting decoction, filters, and filtrate is condensed into thick paste, adds volatile oil clathrate compound, dextrin and xylitol mix homogeneously, adds 70% ethanol and makes soft material, by the agent of soft material granulation.
The further improvement of above-mentioned preparation method is: the relative density of the thick paste that described filtrate is condensed in the time of 60 ℃ is 1.10 ~ 1.20.
The further improvement of above-mentioned preparation method is: described thick paste, dextrin, xylitol three's mass ratio is 1:2:2.
The further improvement of above-mentioned preparation method is: made granule is through being crushed to tablet.
The present invention is used for the Chinese medicine composition of invigorating the spleen to clear away damp pathogen:
Monarch drug: Rhizoma Atractylodis Macrocephalae (parched) the spleen strengthening and damp drying helps fortune, Rhizoma Zingiberis warming middle-JIAO to promote flow of QI reduces phlegm, and the two one mends soil, a warm soil, warming middle-JIAO helps fortune, thick and wet the going of soil, spleen invigorating and body is strong, is monarch drug altogether.
Ministerial drug: Rhizoma Atractylodis are drying damp and strengthening spleen, Poria, Semen Coicis invigorating spleen to remove dampness, help Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying.Cortex Magnoliae Officinalis, Fructus Amomi circulation of qi promoting warming middle-JIAO for eliminating dampness, Pericarpium Citri Reticulatae, Rhizoma Pinelliae dispelling phlegm and eliminating dampness, help Rhizoma Zingiberis warming middle-JIAO to promote flow of QI to reduce phlegm.Upper seven tastes are principal drug assistance spleen invigorating warming middle-JIAO altogether, and dispelling phlegm and eliminating dampness is thought minister.
Adjuvant drug: hawthorn digesting is long-pending, the stasis of blood of reducing phlegm.Fructus Hordei Germinatus soothing liver-QIization is stagnant, promoting digestion and invigorating the stomach.
Make medicine: Radix Glycyrrhizae, coordinating the actions of various ingredients in a prescription.
The effect that top 12 tastes are played invigorating spleen to remove dampness, promoting the circulation of QI and reducing phlegm altogether.
The Rhizoma Atractylodis Macrocephalae, sweet in the mouth, hardship, warm in nature.Enter spleen, stomach warp.Rhizoma Atractylodis Macrocephalae spleen invigorating, and in, dampness, diuretic.Be qi-invigorating herb, cure mainly: the few abdominal distention of deficiency-weakness of spleen-QI, spiritlessness and weakness, lack of appetite, large loose stool are thin, fluid-retention stagnating in the interior, dysuria, edema, dizziness due to fluid-retention, warm numbness are ached, spontaneous sweating due to deficiency of QI, frequent fetal movement." book on Chinese herbal medicine converge with speech ": the Rhizoma Atractylodis Macrocephalae is to foster taste, wet dissipation eliminating impediment, help digestion except the key medicine of painful abdominal mass also." explaining abstruseness of the canon of materia medica ": the Rhizoma Atractylodis Macrocephalae, the medicine of tonifying the spleen and stomach, more unequalled person.Tu Wang can be good for fortune, thus can not trencherman, food stagnation person, has mass in the abdomen person, all use also.Tu Wang can win wet, thus suffer from phlegm retention person, generalized edema with distention of the chest and abdomen person, arthralgia chiefly caused by damp pathogen person, all rely also.Clearing heat in QI system is kind rises for Tu Wang, and gives on precise and tiny, and foul smell is kind falls, and defeated under waste matter, thus vomiting and diarrhoea person, can not fault also.
Rhizoma Zingiberis, acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Rhizoma Zingiberis has warming spleen and stomach for dispelling cold, and recuperating depleted YANG is promoted blood circulation, effect of warming the lung to resolve fluid-retention." herbal classic ": " hemostasis, perspires for main cough with dyspnea uncomfortable in chest, warming middle-JIAO, by rheumatism numbness, and spouting bleeding from anus diarrhea, survivor is especially good." Compendium of Material Medica: " element is said, Rhizoma Zingiberis ... it is with having four: the logical heart is supporing yang, and one also; Remove internal organs chronic diseases, two also; The cold of sending out warp all, three also; Control the cold stomachache of sense, four also." " book on Chinese herbal medicine is looked for the truth ": " and the large heat of Rhizoma Zingiberis is nontoxic, and keep and do not walk, all deficiency-cold of the stomach, Yuanyang wild, is closed with Radix Aconiti Lateralis Preparata with throwing, and can have immediate effect by recuperating depleted YANG, therefore book has the sentence of Radix Aconiti Lateralis Preparata without Jiang Bure.”
Rhizoma Atractylodis, acrid in the mouth hardship, warm in nature.Return spleen, stomach warp.Rhizoma Atractylodis spleen invigorating, dampness, resolving depression, wards off dirty.Control the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia." detailed outline ": " control damp-phlegm prolonged fluid-retention, or hold blood stasis under the arm and become nest capsule, and spleen is wet dirty, turbid drop leukorrhagia, the sliding hemorrhoidal hamorrhage that rushes down." " pearl sac ": " can stomach invigorating pacify spleen, non-this of all damp-edema can not remove.”
Cortex Magnoliae Officinalis, bitter in the mouth, pungent, warm in nature.Return spleen, stomach, lung, large intestine channel.The expectorant of effect dampness, the therapeutic method to keep the adverse QI flowing downwards is except full.Removing dampness by means of aromatics Chinese medicine, cures mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest is breathed with cough.Shennong's Herbal: " main apoplexy typhoid fever, headache, cold and heat, palpitation with fear, QI and blood numbness, dead flesh, goes three worms." " Mingyi Bielu ": " and the expectorant therapeutic method to keep the adverse QI flowing downwards, controls cholera and stomachache for main warming middle-JIAO, QI invigorating, distension, and cold in the stomach is contrary, and vomiting is more than in the heart, lets out dysentery, and drench and reveal, except frightened, going or staying heat, only stuffy sensation with restlessness, thick the intestines and stomach.”
Pericarpium Citri Reticulatae, acrid in the mouth, hardship, warm in nature.Enter spleen channel, stomach warp, lung meridian.Pericarpium Citri Reticulatae has regulating qi-flowing for strengthening spleen, in tune, and dampness, the effect of reducing phlegm." book on Chinese herbal medicine converges and says ": " acrid in the mouth is kind loose, therefore can open gas; The bitter using pungent drugs for dispersion and bitter drugs for purgation of stomach, therefore can manage it expectorant; Its temperature is flat, be good at sensible, therefore can preventing or arresting vomiting, cough-relieving, invigorating the spleen and regulating the stomach person is also.Dong Yuan says: madam is take taste as main, and cures the disease take regulating QI as first, and as wanted regulating QI spleen invigorating person, here the merit of Pericarpium Citri Reticulatae occupies its head.”
The Rhizoma Pinelliae, acrid in the mouth, warm in nature, poisonous; Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm, and middle stomach invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, external can reducing swelling and alleviating pain." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, preventing or arresting vomiting is told, and goes expectorant in the heart to expire, lower lung qi, the main knot of coughing." medicine origin ": control cold-phlegm and cold physique and admire cold injury lung and cough, large easing stomach-QI, except cold syndrome of the stomach, enters diet.Control the headache of sun syncope due to accumulation of phlegm, non-this can not remove." curing mainly secret wanting " cloud, dry stomach is wet, reduces phlegm, strengthening the spleen gastric qi, dispersing swelling and dissipating binds, removes sputum in the heart.
Semen Coicis, sweet in the mouth, light, cold nature.There are invigorating spleen to remove dampness, clearing away heat and discharging pus function." Bencao Tujing ": " for drink is fragrant, beneficial hollow diaphragm." " trifling record ": " the summer-heat moon is decocted drink, warming the stomach, replenishing QI and blood.”
Poria, sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Amplification on Canon of Materia Medica: " Poria, Poria cum Radix Pini, the merit of row water is many, heart-spleen boosting can not fault also." " medication heart method ": " sweet with supporing yang, the panacea of dehumidifying is also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, the inducing QI of promoting the production of body fluid.”
Fructus Amomi, acrid in the mouth, warm in nature.Return spleen channel, stomach warp, kidney channel.Fructus Amomi has removing dampness appetizing, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.Cure mainly turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement." book on Chinese herbal medicine converge with speech ": Fructus Amomi, the gentle medicine of warming middle-JIAO also.
Fructus Crataegi, sweet in the mouth, acid, slightly warm in nature.Have removing food stagnancy, clots absorbing, changes stagnant effect." book on Chinese herbal medicine is looked for the truth ": Fructus Crataegi, so-called spleen invigorating person, because its spleen has food stagnation, with the salty taste of this acid, thinks and wears down, expectorant disappears in order to do food row, broken and the letting out of gas, meaning for strong, only belong to being good for of food stagnation removing." book on Chinese herbal medicine is new again ": control insufficiency of the spleen damp and hotly, the mill that helps digestion is long-pending, sharp defecation.
Fructus Hordei Germinatus, sweet in the mouth, property is flat.Return spleen, stomach warp, Liver Channel.Energy promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension." Japan hanako materia medica ": warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, appetizing, only cholera, relieving restlessness, expectorant.
Radix Glycyrrhizae, sweet in the mouth, property is flat.Enter spleen, stomach, lung meridian.Gas and property are slow, can rise and can fall." book on Chinese herbal medicine is just " said: " Radix Glycyrrhizae, taste to sweet, obtains the property of neutralization, has the merit of adjusting benefits, therefore its poison of the solution that poison obtains, just medicine obtains its property of sum, what medicine administered to bring out the cold obtained helps outside it, put in poison delay its speed.Eliminating evil heat, hard muscles and bones, strengthening the spleen and stomach, longue meat.Enter gas with gas medicine, enter blood with blood medicine, without toward can not, therefore claim state old.”
In order to illustrate that the present invention can carry out intervening sub-health safety by the medicine of conditioning body constitution, spy provides drug toxicology experimental result of the present invention and clinical test results:
(1) zoopery
1. acute toxicological experiment
Application mice carries out acute toxicity testing and shows: mice oral administration gavage Chinese medicine composition of the present invention, under 50.0g crude drug/kg dosage, after administration, mice occurs that light activity reduces, about 1 hour, recover normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage Chinese medicine composition of the present invention is 50.0g crude drug/kg/d (LD50 > 50g crude drug/kg).Chinese medicine composition clinical application every day total amount of the present invention is 0.5g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine composition of the present invention is clinical patient 100.0 times.Point out this medicine acute toxicity low, clinical drug safety.
2. long term toxicity test
Select SD rat, give the Chinese medicine composition of the present invention of variable concentrations (30.0,15.0g crude drug/kg), every day gavage twice, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after administration, the index checkings such as hematology (RBC, HB, PLT, WBC) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks, and wherein hematological examination sees the following form.Result of the test shows: preparation of the present invention is good at high and low dose treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Two dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 60,30 times of clinical medicine dose, rat is had no significant effect in high and low two dosage (30.0,15.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine composition of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine composition clinical practice of the present invention higher.
The impact that above table explanation is learned rat blood: rat, in getting blood with medicamental pulverata docking, is sent the check of biochemical chamber, learns by statistics and processes unknown significance difference (P > 0.05) compared with matched group.
(2) clinical research
1, include in and meet scheme experimenter 60 examples, adopt masculine parallel comparison and self cross-reference method, inquire into the safety of curative effect, the mechanism of action and the medicine of " invigorating the spleen to clear away damp pathogen granule " prevention, treatment phlegm-dampness constitution subhealth state.Be divided at random two groups according to the ratio of 1:1, wherein observation group's 30 examples, matched group 30 examples.Two groups all give health guidance, observation group: oral invigorating the spleen to clear away damp pathogen granule, each 1 bag, 15 grams of granules of every bag, every day 2 times.The oral SHENLING BAISHU SAN of matched group, each 15 grams, be a course for the treatment of at .10 days every day 2 times, observes altogether 3 courses for the treatment of.
2, diagnostic criteria
(1) inclusive criteria: organic disease except comprehensive systems inspection.Be judged to be phlegm-dampness constitution person, 18 ~ 55 years old age according to " Traditional Chinese Medicine Constitution Classification and judgement scale " (China Association of Traditional Chinese Medicine 2009.4).Accept voluntarily intervening measure person.
(2) exclusion standard: find in morbid state person by comprehensive health check-up.Healthy population.Gestation and pregnant women, the women breast-feeding their children of preparation.Suspect or truly have abuse of alcohol, medicine history of past illness.Known to this medicine constituent allergy sufferers.Participating in the patient of other drug clinical trial.Be reluctant partner.All the other rejectings about case etc. are carried out with reference to " new Chinese medicine guideline of clinical investigations ".
3, the standard of curative effect evaluation
Comprehensive therapeutic effect carries out qualitative sxemiquantitative treatment front and back trade-off mainly for relevant symptom.By 4 level methods scorings (0=without, 2=has once in a while, 4=often has, 6=continues to have), calculate total mark.Adopt nimodipine method, effective: most of transference cure after treatment, symptom integral number declines and is more than or equal to 2/3; Effective: treatment rear section symptom takes a turn for the better, and the decline of symptom integral number is greater than 1/3 and is less than 2/3; Invalid: the rear symptom for the treatment of takes a turn for the better not obvious, and symptom integral number declines and is less than or equal to 1/3.
4, observation index:
(1) curative effect index phlegm-dampness constitution subhealth symptom: adopt from intending the phlegm-dampness constitution subhealth symptom table of integrals, observe before and after treatment Self-variation and carry out self and group between relatively.
(2) objective indicator: hemorheology, bleed subhealth state detect (MDI)
(3) safety indexes safety indexes is mainly observed serum TG, TC, and blood, urine, stool routine examination, liver function, kidney merit are carried out Ecg simultaneously.
5, statistical analysis technique: statistical procedures adopts SAS 9.0 statistical softwares to calculate, and all statistical test all adopt two-sided test, and P<0.05 is considered to checked difference statistical significance.Measurement data is adopted to t check, and enumeration data adopts CMH X 2 test and rank test.
6, therapeutic outcome is in table 1
Table 1 statistical analysis prompting: the total effective rate comparison for the treatment of group and treatment of control group heart syndrome of feeling fullness and distension in the upper abdomen, difference has remarkable statistical significance (P<0.01).
Table 3 statistical analysis prompting: before treatment, treatment group and matched group, relatively in each field of quality of life, are showed no significant difference (P>0.05); Before and after two groups of treatments, aspect quality of life subjective sensation, health status subjective sensation, physiological field, moral domain, self life overall merit, all there is remarkable significant difference (P<0.01), in social relations field, there is significant difference (P<0.05) in surrounding field; After treatment, aspect moral domain, self life overall merit, two groups relatively have significant difference (P<0.05).
The beneficial effect of this programme can be learnt according to the narration to such scheme, due to the exclusive organic conception of Chinese medicine and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system, and the integrally-regulated feature of multi-level, the too many levels that has of Chinese medicine compound, multipath, many target spots, meet the characteristics of incidence of phlegm-dampness constitution subhealth state completely; In this Chinese medicine composition, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Semen Coicis, Fructus Crataegi, Fructus Hordei Germinatus etc. are medicine-food two-purpose kind on the one hand, the property of medicine is gentle, high safety, Chinese herbal medicine price economy material benefit on the other hand, in improving curative effect, reduce patient's medical expense, effectively saved health resources, there is vast potential for future development.
In we, Rhizoma Atractylodis Macrocephalae (parched) the spleen strengthening and damp drying helps fortune, and Rhizoma Zingiberis warming middle-JIAO to promote flow of QI reduces phlegm, and the two one mends soil, a warm soil, and warming middle-JIAO helps fortune, thick and wet the going of soil, spleen invigorating and body is strong, is monarch drug altogether.Rhizoma Atractylodis are drying damp and strengthening spleen, and Poria, Semen Coicis invigorating spleen to remove dampness, help Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying.Cortex Magnoliae Officinalis, Fructus Amomi circulation of qi promoting warming middle-JIAO for eliminating dampness, Pericarpium Citri Reticulatae, Rhizoma Pinelliae dispelling phlegm and eliminating dampness, help Rhizoma Zingiberis warming middle-JIAO to promote flow of QI to reduce phlegm.Hawthorn digesting is long-pending, the stasis of blood of reducing phlegm.Fructus Hordei Germinatus soothing liver-QIization is stagnant, promoting digestion and invigorating the stomach.The effect property of medicine of playing altogether invigorating spleen to remove dampness, promoting the circulation of QI and reducing phlegm is gentle, high safety.With SHENLING BAISHU SAN comparison, reusing Rhizoma Zingiberis is monarch drug warming middle-JIAO, Rhizoma Atractylodis dampness, and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Pinelliae promoting the circulation of QI and reducing phlegm, effect is remarkable, is applicable to have a liking for food delicious food, obesity, god is tired, is fond of tranquility lazy moving, and breast gastral cavity painful abdominal mass is vexed, and limbs are tired heavy, sticky in mouthful, loose stool is not well, corpulent tongue, and moist and slippery fur is greasy, soft pulse and sliding.As can be seen here, the present invention compared with prior art, has outstanding substantive distinguishing features and significant progressive, and the beneficial effect of its enforcement is also apparent.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Chinese medicine composition composition formula: 350 grams of Rhizoma Atractylodis Macrocephalae (parched)s, 350 grams of Rhizoma Zingiberiss, 120 grams of Rhizoma Atractylodis (parched), 120 grams of Cortex Magnoliae Officinalis, 120 grams of Pericarpium Citri Reticulataes, 120 grams of Rhizoma Pinelliae, 180 grams of raw pearl barleys, 180 grams, Poria, 120 grams of clean Fructus Amomis, 180 grams of Fructus Crataegi, 180 grams of Fructus Hordei Germinatus, 120 grams of Radix Glycyrrhizae.
Preparation method:
This preparation method comprises the steps: Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Zingiberis, Rhizoma Atractylodis (parched), Pericarpium Citri Reticulatae, clean Fructus Amomi five kinds of Chinese medicine to extract volatile oil, with beta-cyclodextrin inclusion compound, for subsequent use; Medicinal residues and Cortex Magnoliae Officinalis, Rhizoma Pinelliae, raw pearl barley, Poria, Fructus Crataegi, Fructus Hordei Germinatus, the Radix Glycyrrhizae of five kinds of Chinese medicine that extracts volatile oil decocts with water 2 times, and amount of water is drug weight 12 times for the first time, boils rear lasting decoction 1.5 hours; Amount of water is drug weight 8 times for the second time, continues to boil 1 hour after boiling, and collecting decoction, filters, and filtrate is condensed into thick paste, adds volatile oil clathrate compound, dextrin and xylitol mix homogeneously, adds 70% ethanol and makes soft material, by the agent of soft material granulation.
The further improvement of above-mentioned preparation method is: the relative density of the thick paste that described filtrate is condensed in the time of 60 ℃ is 1.10.
The further improvement of above-mentioned preparation method is: described thick paste, dextrin, xylitol three's mass ratio is 1:2:2.
Comparative example:
SHENLING BAISHU SAN: 9 grams of Semen Nelumbinis, 9 grams of Semen Coiciss, 6 grams of Fructus Amomis, 6 grams of Radix Platycodoniss, 12 grams of Semen Lablab Albums, 15 grams of Porias, 15 grams of Radix Ginsengs, 9 grams of Radix Glycyrrhizae Preparatas, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 15 grams of Rhizoma Dioscoreaes.In the party, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, the eliminating dampness by diuresis of Poria replenishing QI to invigorate the spleen are monarch.Compatibility Rhizoma Dioscoreae, Semen Nelumbinis principal drug assistance be with invigorating the spleen and benefiting QI, and holding concurrently can antidiarrheal; And help the Rhizoma Atractylodis Macrocephalae, Poria with spleen invigorating eliminating dampness by diuresis with Semen Lablab Album, Semen Coicis, be ministerial drug.More, with the Fructus Amomi stomach function regulating of being amusing, promoting qi circulation, resolving food retention, is to be adjuvant drug.Radix Platycodonis lung qi dispersing promoting the circulation of QI, regulating fluid apssage, again can medicine carrying up, building up the spleen to supplement the lung; Radix Glycyrrhizae (parched) spleen invigorating and in, coordinating the actions of various ingredients in a prescription, altogether for assistant makes.Take a broad view of full side, invigorating middle warmer gas, eliminating dampness by diuresis is turbid, and circulation of qi promoting is stagnant, makes the strong fortune of temper, and damp must be gone.
Embodiment 1 compares with comparative example: SHENLING BAISHU SAN is take spleen invigorating QI invigorating as main, the eliminating dampness by diuresis antidiarrheal of holding concurrently.And embodiment 1 is for modern's mode feature of living, take the damp eliminating of spleen invigorating YANG invigorating as main, the promoting the circulation of QI and reducing phlegm of holding concurrently.The power weight of damp eliminating.
Modern's dampness is heavy especially, and this and modern's living habit is relevant.First: modern's cold drink is drunk often.In summer in winter no matter now, everybody drinks cold drink, cold drink impairment of the spleen sun, and YANG QI deficiency, water is wet not to be controlled.The second, modern's air-conditioning blows manyly, and the most important principle of the traditional Chinese medical science is the correspondence between man and universe, and our health can change along with difference in season, should be heat original summer, skin using pungent drugs for dispersion and bitter drugs for purgation, lung governing skin and hair, pore is opened a business, and just out, lung qi can make body fluid walk toward outside to antiperspirant, the traditional Chinese medical science says, this in summer in season yang-energy outside, if this time, we turned on the aircondition, sweating is not smooth, body fluid metabolic imbalance, damage lung qi, the main water of lung, transporting deficiency, raw expectorant is raw wet.
Reduce phlegm therefore the present embodiment 1 is reused Rhizoma Zingiberis warming middle-JIAO to promote flow of QI, Rhizoma Atractylodis Macrocephalae (parched) the spleen strengthening and damp drying helps fortune, and the two one mends soil, a warm soil, and warming middle-JIAO helps fortune, thick and wet the going of soil, spleen invigorating and body is strong, is monarch drug altogether.Add Rhizoma Atractylodis toil warm-dryness syndrome, kind drying damp and strengthening spleen, Poria, Semen Coicis invigorating spleen to remove dampness, help Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying.The bitter temperature fragrance of Cortex Magnoliae Officinalis, circulation of qi promoting is loose full, helps Rhizoma Atractylodis dehumidifying activating the spleen, is to be minister.Regulating the flow of vital energy of Pericarpium Citri Reticulatae is stagnant, Rhizoma Pinelliae dispelling phlegm and eliminating dampness, helps Rhizoma Zingiberis warming middle-JIAO to promote flow of QI to reduce phlegm, and closes the lifting of Cortex Magnoliae Officinalis with multiple taste.Hawthorn digesting is long-pending, the stasis of blood of reducing phlegm.Fructus Hordei Germinatus soothing liver-QIization is stagnant, and promoting digestion and invigorating the stomach is adjuvant drug altogether.The effect property of medicine of playing altogether invigorating spleen to remove dampness, promoting the circulation of QI and reducing phlegm is gentle, high safety.Be applicable to have a liking for food delicious food, obesity, god is tired, is fond of tranquility lazy moving, and breast gastral cavity painful abdominal mass is vexed, and limbs are tired heavy, and sticky in mouthful, loose stool is not well, corpulent tongue, moist and slippery fur is greasy, soft pulse and sliding.With SHENLING BAISHU SAN comparison, reusing Rhizoma Zingiberis is monarch drug warming middle-JIAO, Rhizoma Atractylodis dampness, and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Pinelliae promoting the circulation of QI and reducing phlegm, effect is remarkable, is applicable to have a liking for food delicious food, obesity, god is tired, is fond of tranquility lazy moving, and breast gastral cavity painful abdominal mass is vexed, and limbs are tired heavy, sticky in mouthful, loose stool is not well, corpulent tongue, and moist and slippery fur is greasy, soft pulse and sliding.
Embodiment 2:
The formula of Chinese medicine composition: 250 grams of Rhizoma Atractylodis Macrocephalae (parched)s, 250 grams of Rhizoma Zingiberiss, 80 grams of Rhizoma Atractylodis (parched), 80 grams of Cortex Magnoliae Officinalis, 80 grams of Pericarpium Citri Reticulataes, 80 grams of Rhizoma Pinelliae, 120 grams of raw pearl barleys, 120 grams, Poria, 80 grams of clean Fructus Amomis, 120 grams of Fructus Crataegi, 120 grams of Fructus Hordei Germinatus, 80 grams of Radix Glycyrrhizae.
Compare with embodiment 1: the content of each component of embodiment 2 all reduces to some extent, meet the exclusive organic conception of Chinese medicine and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system, and the integrally-regulated feature of multi-level, the too many levels that has of Chinese medicine compound, multipath, many target spots, also meet the characteristics of incidence of phlegm-dampness constitution subhealth state.
Preparation method:
This preparation method comprises the steps: Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Zingiberis, Rhizoma Atractylodis (parched), Pericarpium Citri Reticulatae, clean Fructus Amomi five kinds of Chinese medicine to extract volatile oil, with beta-cyclodextrin inclusion compound, for subsequent use; Medicinal residues and Cortex Magnoliae Officinalis, Rhizoma Pinelliae, raw pearl barley, Poria, Fructus Crataegi, Fructus Hordei Germinatus, the Radix Glycyrrhizae of five kinds of Chinese medicine that extracts volatile oil decocts with water 2 times, and amount of water is drug weight 12 times for the first time, boils rear lasting decoction 1.5 hours; Amount of water is drug weight 8 times for the second time, continues to boil 1 hour after boiling, and collecting decoction, filters, and filtrate is condensed into thick paste, adds volatile oil clathrate compound, dextrin and xylitol mix homogeneously, adds 70% ethanol and makes soft material, by the agent of soft material granulation.
The further improvement of above-mentioned preparation method is: the relative density of the thick paste that described filtrate is condensed in the time of 60 ℃ is 1.20.
The further improvement of above-mentioned preparation method is: described thick paste, dextrin, xylitol three's mass ratio is 1:2:2.
Embodiment 3:
The formula of Chinese medicine composition: 300 grams of Rhizoma Atractylodis Macrocephalae (parched)s, 300 grams of Rhizoma Zingiberiss, 100 grams of Rhizoma Atractylodis (parched), 100 grams of Cortex Magnoliae Officinalis, 100 grams of Pericarpium Citri Reticulataes, 100 grams of Rhizoma Pinelliae, 150 grams of raw pearl barleys, 150 grams, Poria, 100 grams of clean Fructus Amomis, 150 grams of Fructus Crataegi, 150 grams of Fructus Hordei Germinatus, 100 grams of Radix Glycyrrhizae.
Compare with embodiment 1: the content of each component of embodiment 3 all reduces to some extent, meet the exclusive organic conception of Chinese medicine and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system, and the integrally-regulated feature of multi-level, the too many levels that has of Chinese medicine compound, multipath, many target spots, also meet the characteristics of incidence of phlegm-dampness constitution subhealth state.
The difference of this preparation method and embodiment 1 is: made granule is through being crushed to tablet.
Embodiment 4:
The formula of Chinese medicine composition: 280 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 280 parts of Rhizoma Zingiberiss, 90 parts of Rhizoma Atractylodis (parched), 90 parts of Cortex Magnoliae Officinalis, 90 parts of Pericarpium Citri Reticulataes, 90 parts of Rhizoma Pinelliae, 130 parts of raw pearl barleys, 130 parts, Poria, 90 parts of clean Fructus Amomis, 130 parts of Fructus Crataegi, 130 parts of Fructus Hordei Germinatus, 90 parts of Radix Glycyrrhizae.
Compare with embodiment 1: the content of each component of embodiment 4 all reduces to some extent, meet the exclusive organic conception of Chinese medicine and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system, and the integrally-regulated feature of multi-level, the too many levels that has of Chinese medicine compound, multipath, many target spots, also meet the characteristics of incidence of phlegm-dampness constitution subhealth state.
This preparation method is with embodiment 1.
Embodiment 5
The formula of Chinese medicine composition: 320 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 320 parts of Rhizoma Zingiberiss, 110 parts of Rhizoma Atractylodis (parched), 110 parts of Cortex Magnoliae Officinalis, 110 parts of Pericarpium Citri Reticulataes, 110 parts of Rhizoma Pinelliae, 170 parts of raw pearl barleys, 170 parts, Poria, 110 parts of clean Fructus Amomis, 170 parts of Fructus Crataegi, 170 parts of Fructus Hordei Germinatus, 110 parts of Radix Glycyrrhizae.
Compare with embodiment 1: the content of each component of embodiment 5 all reduces to some extent, meet the exclusive organic conception of Chinese medicine and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system, and the integrally-regulated feature of multi-level, the too many levels that has of Chinese medicine compound, multipath, many target spots, also meet the characteristics of incidence of phlegm-dampness constitution subhealth state.
This preparation method is with embodiment 1.
The present invention can pass through existing techniques in realizing without the technical characterictic of describing, and does not repeat them here.Certainly; above-mentioned explanation is not limitation of the present invention; the present invention is also not limited in above-mentioned giving an example, and variation, remodeling, interpolation or replacement that those skilled in the art make in essential scope of the present invention, also should belong to protection scope of the present invention.
Claims (8)
1. a Chinese medicine composition for invigorating the spleen to clear away damp pathogen, is characterized in that: this Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Atractylodis Macrocephalae (parched) 250-350 part, Rhizoma Zingiberis 250-350 part, Rhizoma Atractylodis (parched) 80-120 part, Cortex Magnoliae Officinalis 80-120 part, Pericarpium Citri Reticulatae 80-120 part, Rhizoma Pinelliae 80-120 part, raw pearl barley 120-180 part, Poria 120-180 part, clean Fructus Amomi 80-120 part, Fructus Crataegi 120-180 part, Fructus Hordei Germinatus 120-180 part, Radix Glycyrrhizae 80-120 part.
2. the Chinese medicine composition of invigorating the spleen to clear away damp pathogen according to claim 1, is characterized in that: this Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Atractylodis Macrocephalae (parched) 280-320 part, Rhizoma Zingiberis 280-320 part, Rhizoma Atractylodis (parched) 90-110 part, Cortex Magnoliae Officinalis 90-110 part, Pericarpium Citri Reticulatae 90-110 part, Rhizoma Pinelliae 90-110 part, raw pearl barley 130-170 part, Poria 130-170 part, clean Fructus Amomi 90-110 part, Fructus Crataegi 130-170 part, Fructus Hordei Germinatus 130-170 part, Radix Glycyrrhizae 90-110 part.
3. the Chinese medicine composition of invigorating the spleen to clear away damp pathogen according to claim 2, is characterized in that: this Chinese medicine composition is made up of the raw material of following weight portion: 300 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 300 parts of Rhizoma Zingiberiss, 100 parts of Rhizoma Atractylodis (parched), 100 parts of Cortex Magnoliae Officinalis, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Rhizoma Pinelliae, 150 parts of raw pearl barleys, 150 parts, Poria, 100 parts of clean Fructus Amomis, 150 parts of Fructus Crataegi, 150 parts of Fructus Hordei Germinatus, 100 parts of Radix Glycyrrhizae.
4. according to the Chinese medicine composition of the invigorating the spleen to clear away damp pathogen described in claim 1 or 2 or 3, it is characterized in that: this Chinese medicine composition is made following dosage form: granule, pill, tablet, capsule.
5. according to the preparation method of the Chinese medicine composition of the invigorating the spleen to clear away damp pathogen described in claim 1 or 2 or 3, it is characterized in that: this preparation method comprises the steps: Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Zingiberis, Rhizoma Atractylodis (parched), Pericarpium Citri Reticulatae, clean Fructus Amomi five kinds of Chinese medicine to extract volatile oil, with beta-cyclodextrin inclusion compound, for subsequent use; Medicinal residues and Cortex Magnoliae Officinalis, Rhizoma Pinelliae, raw pearl barley, Poria, Fructus Crataegi, Fructus Hordei Germinatus, the Radix Glycyrrhizae of five kinds of Chinese medicine that extracts volatile oil decocts with water 2 times, and amount of water is drug weight 12 times for the first time, boils rear lasting decoction 1.5 hours; Amount of water is drug weight 8 times for the second time, continues to boil 1 hour after boiling, and collecting decoction, filters, and filtrate is condensed into thick paste, adds volatile oil clathrate compound, dextrin and xylitol mix homogeneously, adds 70% ethanol and makes soft material, by the agent of soft material granulation.
6. the preparation method of the Chinese medicine composition of invigorating the spleen to clear away damp pathogen according to claim 5, is characterized in that: the relative density of the thick paste that described filtrate is condensed in the time of 60 ℃ is 1.10 ~ 1.20.
7. the preparation method of the Chinese medicine composition of invigorating the spleen to clear away damp pathogen according to claim 5, is characterized in that: described thick paste, dextrin, xylitol three's mass ratio is 1:2:2.
8. the preparation method of the Chinese medicine composition of invigorating the spleen to clear away damp pathogen according to claim 5, is characterized in that: made granule is through being crushed to tablet.
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| CN104547987A (en) * | 2014-11-28 | 2015-04-29 | 丁鸿磊 | Traditional Chinese medicine drink for caring stomach and preparation method of traditional Chinese medicine drink |
| CN105288431A (en) * | 2015-12-02 | 2016-02-03 | 肖燕萍 | Soup for tonifying spleen and removing dampness as well as reducing phlegm |
| CN106138905A (en) * | 2016-08-20 | 2016-11-23 | 林力 | Invigorating the spleen to clear away damp pathogen Tea containing traditional Chinese medicine side |
| CN106690305A (en) * | 2016-11-17 | 2017-05-24 | 巫山县国轻餐饮文化有限公司 | Preparation method for coix seed-largehead atractylodes rhizome paste |
| CN107281435A (en) * | 2017-08-23 | 2017-10-24 | 湖北百草济世中医科技有限公司 | It is a kind of to dispel clearing damp decoction particles of body moisture and preparation method thereof |
| CN114224962A (en) * | 2022-01-07 | 2022-03-25 | 曹音 | Spleen-tonifying and dampness-eliminating composition and navel patch thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547987A (en) * | 2014-11-28 | 2015-04-29 | 丁鸿磊 | Traditional Chinese medicine drink for caring stomach and preparation method of traditional Chinese medicine drink |
| CN104547987B (en) * | 2014-11-28 | 2018-07-27 | 丁鸿磊 | A kind of Chinese herbal medicine beverage of care stomach and preparation method thereof |
| CN105288431A (en) * | 2015-12-02 | 2016-02-03 | 肖燕萍 | Soup for tonifying spleen and removing dampness as well as reducing phlegm |
| CN106138905A (en) * | 2016-08-20 | 2016-11-23 | 林力 | Invigorating the spleen to clear away damp pathogen Tea containing traditional Chinese medicine side |
| CN106690305A (en) * | 2016-11-17 | 2017-05-24 | 巫山县国轻餐饮文化有限公司 | Preparation method for coix seed-largehead atractylodes rhizome paste |
| CN107281435A (en) * | 2017-08-23 | 2017-10-24 | 湖北百草济世中医科技有限公司 | It is a kind of to dispel clearing damp decoction particles of body moisture and preparation method thereof |
| CN114224962A (en) * | 2022-01-07 | 2022-03-25 | 曹音 | Spleen-tonifying and dampness-eliminating composition and navel patch thereof |
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Application publication date: 20140528 |