CN102886038A - Traditional Chinese medicine preparation for losing weight and preparation method of traditional Chinese medicine preparation - Google Patents

Traditional Chinese medicine preparation for losing weight and preparation method of traditional Chinese medicine preparation Download PDF

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CN102886038A
CN102886038A CN2012104145763A CN201210414576A CN102886038A CN 102886038 A CN102886038 A CN 102886038A CN 2012104145763 A CN2012104145763 A CN 2012104145763A CN 201210414576 A CN201210414576 A CN 201210414576A CN 102886038 A CN102886038 A CN 102886038A
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weight portions
chinese medicine
radix
rhizoma
weight
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CN102886038B (en
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王彦进
肖义青
陈振雨
类成刚
朱月华
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王彦进
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Abstract

The invention discloses a traditional Chinese medicine preparation for losing weight and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine comprises the following raw materials: astragalus mongholicus, codonopsis pilosula, radix paeoniae alba, radix bupleuri, haw, medicated leaven, lotus leaf, fructus ligustri lucidi, subprostrate sophora, dogwood, semen pruni, the root bark of white mulberry, phaseolus calcaratus, cogongrass rhizome, rhizoma atractylodis, mangnolia officinalis, pericarpium citri reticulatae, prepared rehmannia root, radix curcumae, rhizoma zingiberis, eupatorium, coptis chinensis, rhizoma phragmitis, semen brassicae, rhizoma pinellinae praeparata, loranthus parasiticus, sargassum, the fruit of Chinese wolfberry and plantain seed. The traditional Chinese medicine preparation has the beneficial effects that the traditional Chinese medicine provided by the invention is completely prepared from the pure-natural traditional Chinese medicine ingredients, is good for human body, has no side effects, is free of toxicity, does not need excessive dieting, only needs proper attention without excessive feeding, is good in curative effect, can convert and remove redundant fat and water-dampness remained in human body caused by metabolism, can not injure the healthy atmosphere and the physiological function of human body, can get rid of the stale and bring forth the fresh for human body, can promote the metabolism, can fit the body shape, can eliminate the garbage in human body, can eliminate the disease hidden trouble, and is free from rebound after losing weight.

Description

A kind of Chinese medicine preparation and preparation method for fat-reducing

Technical field

The present invention relates to the engineering of traditional Chinese medicine technical field, relate in particular to a kind of Chinese medicine preparation and preparation method for fat-reducing.

Background technology

The traditional Chinese medical science is just on the books as far back as Huangdi's Internal Classics, and the people has fertilizer, and cream is arranged, meat is arranged, point out fat characteristics: figure is fat, greasiness, the Blood Viscosity silk fabric, operation slowly this be Sorghum vulgare Pers. disease also, many surfeit of people delicious food savoury of obesity hinders taste, make dysfunction of the spleen in transportation, essence of water and grain can not be changed promoting generation of vital essence and blood, forms cream fat expectorant and holds in turbid, holds in skin to form obesity; Taste excess-heat rapid digestion of food is apt to flesh, polyphagia polydipsia and cause QI and blood and have a surplus, change cream fat and in hold and also can cause fat; Liver controlling conveyance and dispersion, if the depressed expectorant of Shu Ze is solidifying for long-term feelings will, or catharsis imbalance and cause dysfunction of the spleen in transportation, give birth in the phlegm-damp; Kidney master water, deficiency of kidney-QI then can not promote the circulation of qi and water, stop in the turbid damp and cause, and overflow in skin, and it are fat to cause fat; Worn with age, vital organs of the human body hypofunction, essence of water and grain can not normally be failed cloth and also can cause and stop in the turbid damp and cause fat fat.

Modern medicine study shows, obesity has become the root that causes various diseases in the society, and data show according to statistics, and in obese people, 90% obese patient suffers from the three-hypers diseases such as hypertension, hyperlipidemia, hyperglycemia; 70% obese patient suffers from coronary heart disease, cardiovascular disease, has simultaneously 50% patient to have the diseases such as gout, cholelithiasis, cholecystitis; 78% obese patient can change into diabetes, insulin deficit disease, wherein has again 90% patient the diseases such as acute and chronic pancreatitis can occur; 90% obese patient suffers from cerebral arteriosclerosis, cerebral thrombosis, brain kinetic energy microcirculation is real transfers, and wherein the diseases such as apoplexy, hemiplegia and numb limbs and tense tendons can appear in majority; The diseases such as dementia, insomnia, forgetful and osteoporosis also can appear in senile obese patient.At present Chinese annual obese patient just increases with 5% ratio, and occurred to infant, children and adolescents etc. become younger the development trend, China is annual because of the various diseases for the treatment of by the obesity initiation, accounted for 2~3% of GDP, this shows, prevention and treatment of obesity also become the major issue that is related to population health and national sustainable development.

Obesity is the too much accumulation that causes body fat owing to the absorption of energy above the consumption of energy, makes the body fat overheap, and body weight increases.The definition of definite obesity refers to that body fat increases unusually, but not the exceeding standard of body weight.According to the cause of disease, obesity can be divided into pure and Secondary cases two classes.Simple Obesity refers to only have obesity and without the obesity of any organic disease.Simple Obesity can be divided into again the constitutional obesity of onset childhood and the acquired obesity of adult onset.Simple Obesity may be with inherited genetic factors, central nervous system's appetite stimulator, endocrine function change, metabolic factor and sit quietly, the living habit of polyphagia etc. is relevant.The cause of disease and pathogenesis that Secondary Obesity is secondary to the Simple Obesity such as the inflammation, tumor, wound, hypercortisolism, hypothyroidism, hypogonadism, type diabetes of some disease such as hypothalamus one hypophysis is early stage, insulinoma more still imperfectly understand, may be relevant with following factors.Inherited genetic factors, epidemiology show that some overweight people has family's morbidity tendency.Neuropsychical facto, zoopery and clinical observation show that nervous and mental factors is to people's the regulating action of having ingested.Endocrine factors, many hormones such as thyroxine, insulin, glucocorticoid etc. may participate in the pathogenesis of obesity.Life style and dietary habit do not like that movable people's consumed energy reduces, and easily occur fat.The athlete is after stop motion, often take the photograph the high calorie diet of people or heavy, smoker after smoking cessation, Food intake before bed custom, the greasy food of liking consuming oil, the every day few and every meal food-intake of number of times of having meal is large etc. all relevant with the generation of Simple Obesity, but is not unique cause of disease.

The most of slimming medicines of slimming medicine present situation such as appetite suppressant, diuretic, cathartic etc. have the side effect of varying degree both at home and abroad.Slimming medicine salable mainly contains in the world at present: the sibutramine in Germany (Ke Nuo) KNOLL pharmaceutical factory; The orlistat of Switzerland Roche Holding Ag.The proposition of this concept of losing weight only is about ten years thing in China, and diet products are through having walked the renewal course of develop rapidly.The mid-90 in 20th century, weight-reducing product market experienced twice product renewal so far.The first generation is rushed down clearly the type diet products and mostly traditional diet tea is improved, and utilizes the Folium Camelliae sinensis esterified greasy effect of dispelling to lose weight.In order to embody the effect of quick weight-lossing, some producers have added cathartic such as the Chinese herbal medicine such as Radix Et Rhizoma Rhei, Natrii Sulfas and sennae that dosage does not wait in diet tea, by moisture and protein in the mode human body of diarrhoea, what cause is the illusion that loses weight, and but fails to touch the basic of obesity.These diet teas of long-term taking also can cause damage to function of human body, the symptoms such as habitual diarrhea, gastrointestinal dysfunction and human body dehydration occur.The hungry substituted type diet products of the second filial generation reach the fat-reducing purpose by " going on a diet ", namely replace normal diet with low-calorie diet, to reduce human body to the absorption of fat, saccharide, rely on the consumption of human body own fat to come makeup energy.In order to cause the sensation of " having had enough ", also add the medicines (inactive in the U.S. at present) such as appetite suppressant fenfluramine, An Feila ketone in some substituted type diet food.Life-time service can make health be in starvation, has not only reduced the mobility of body each side, in case cut out, body weight just can quick rebound.Third generation health type diet products take World Health Organization (WHO) propose do not suffer from diarrhoea, do not go on a diet and not weak for the principle of losing weight, effect increases than the first generation, second filial generation diet products.

Medicine, health product in market prevention and treatment of obesity are multifarious, of a great variety, the principle of its fat-reducing is the means that are absorbed as with appetite-suppressing and oil-control, science and be exactly to adjust human dietary structure by the generally accepted mode of patient wherein, improve food quality, reduce human body to the intake of oils and fats, meat, eggs and carbohydrate food, shortcoming is to have reduced human enjoying to the full ambrosia.And the side reaction of the functions such as liver, kidney, heart appears affecting in these medicines by oral fat-reducing, health product sometimes.Simultaneously medical research shows, oils and fats in the body fat, mainly containing two class chemical substances forms, one class be satisfied fatty acid fat account for fatty oils and fats 79%, to belong to the material that is difficult for oxidized, decomposition, metabolism, be easy to be gathered in the subcutaneous fat, during sometimes this class material intravasation circulation, also easily form the thrombosis condensation product, occlude blood is mobile, increases the stickiness of blood, reduce blood flow, thereby can produce brain and support deficiency, cause vasospasm and contraction, cause the diseases such as coronary heart disease, cardiovascular disease, cerebral arteriosclerosis, apoplexy, hemiplegia and dementia.This also is main harmful material that the obese patient falls ill.Another kind of be unsaturated fatty acid account for total fatty oils and fats 20%, it is the material that a class is absorbed by the body, transforms, it also is the energy component of each organ metabolism requirement of human body, this constituents also has the effect of thrombosis, arrhythmia, anti-cerebral arteriosclerosis in antiinflammatory, the anti-blood in human body simultaneously, is the material to the human body beneficial.Modern medicine study confirms, unsaturated fatty acid prevents the effect of the diseases such as coronary heart disease, cardiovascular disease, diabetes, cancer, hepatitis, cerebral arteriosclerosis, apoplexy, hemiplegia, dull-witted depression, psychotic disorder, rheumatoid and rheumatic arthritis, neurodermatitis, emphysema, asthma, nephritis in addition, and this class material or the important composition material of human brain liposome.How neither to affect human body health, effectively controlling again fat, to reach attractive in appearance and healthy purpose be to need the technical barrier of solution badly.

Summary of the invention

Technical problem to be solved by this invention is, overcome existing diet products side effect large, unsuitable life-time service and the defective that easily rebounds, utilize the traditional theory of Chinese medical science of China, a kind of novel Chinese medicine preparation that is used for fat-reducing is provided, selects the natural Chinese medicines composition fully, human body is free from side effects, avirulence does not rebound after good effect and the weight reducing.

Ask in order to solve above-mentioned technology, the invention provides a kind of Chinese medicine preparation for fat-reducing, comprise following raw medicinal material in the described Chinese medicine preparation: the Radix Astragali, Radix Codonopsis, the Radix Paeoniae Alba, Radix Bupleuri, Fructus Crataegi, Massa Medicata Fermentata, Folium Nelumbinis, Fructus Ligustri Lucidi, Radix Sophorae Tonkinensis, Fructus Corni, Semen Pruni, Cortex Mori, Semen Phaseoli, Rhizoma Imperatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, Radix Curcumae, Rhizoma Zingiberis, Herba Eupatorii, Rhizoma Coptidis, Rhizoma Phragmitis, Semen Sinapis Albae, Rhizoma Pinelliae Preparatum, Herba Taxilli, Sargassum, Fructus Lycii and Semen Plantaginis.

The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine preparation can be preferably: the Radix Astragali 10~30 weight portions, Radix Codonopsis 10~30 weight portions, the Radix Paeoniae Alba 10~30 weight portions, Radix Bupleuri 10~30 weight portions, Fructus Crataegi 10~20 weight portions, Massa Medicata Fermentata 10~20 weight portions, Folium Nelumbinis 10~20 weight portions, Fructus Ligustri Lucidi 10~20 weight portions, Radix Sophorae Tonkinensis 10~20 weight portions, Fructus Corni 10~15 weight portions, Semen Pruni 10~15 weight portions, Cortex Mori 10~15 weight portions, Semen Phaseoli 10~15 weight portions, Rhizoma Imperatae 10~15 weight portions, Rhizoma Atractylodis 8~12 weight portions, Cortex Magnoliae Officinalis 8~12 weight portions, Pericarpium Citri Reticulatae 8~12 weight portions, Radix Rehmanniae Preparata 8~12 weight portions, Radix Curcumae 8~12 weight portions, Rhizoma Zingiberis 15~25 weight portions, Herba Eupatorii 15~25 weight portions, Rhizoma Coptidis 6~10 weight portions, Rhizoma Phragmitis 15~25 weight portions, Semen Sinapis Albae 15~25 weight portions, Rhizoma Pinelliae Preparatum 15~25 weight portions, Herba Taxilli 15~25 weight portions, Sargassum 8~15 weight portions, Fructus Lycii 15~25 weight portions and Semen Plantaginis 15~25 weight portions.

The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine preparation can also be preferably: the Radix Astragali 20~30 weight portions, Radix Codonopsis 20~30 weight portions, the Radix Paeoniae Alba 20~30 weight portions, Radix Bupleuri 20~30 weight portions, Fructus Crataegi 15~20 weight portions, Massa Medicata Fermentata 15~20 weight portions, Folium Nelumbinis 15~20 weight portions, Fructus Ligustri Lucidi 15~20 weight portions, Radix Sophorae Tonkinensis 15~20 weight portions, Fructus Corni 10~12 weight portions, Semen Pruni 10~12 weight portions, Cortex Mori 10~12 weight portions, Semen Phaseoli 10~12 weight portions, Rhizoma Imperatae 10~12 weight portions, Rhizoma Atractylodis 8~10 weight portions, Cortex Magnoliae Officinalis 8~10 weight portions, Pericarpium Citri Reticulatae 8~10 weight portions, Radix Rehmanniae Preparata 8~10 weight portions, Radix Curcumae 8~10 weight portions, Rhizoma Zingiberis 15~20 weight portions, Herba Eupatorii 15~20 weight portions, Rhizoma Coptidis 6~8 weight portions, Rhizoma Phragmitis 15~20 weight portions, Semen Sinapis Albae 15~20 weight portions, Rhizoma Pinelliae Preparatum 15~20 weight portions, Herba Taxilli 15~20 weight portions, Sargassum 8~10 weight portions, Fructus Lycii 20~25 weight portions and Semen Plantaginis 20~25 weight portions.

The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine preparation can be preferably again: the Radix Astragali 25 weight portions, Radix Codonopsis 25 weight portions, the Radix Paeoniae Alba 25 weight portions, Radix Bupleuri 25 weight portions, Fructus Crataegi 16 weight portions, Massa Medicata Fermentata 16 weight portions, Folium Nelumbinis 16 weight portions, Fructus Ligustri Lucidi 16 weight portions, Radix Sophorae Tonkinensis 16 weight portions, Fructus Corni 10 weight portions, Semen Pruni 10 weight portions, Cortex Mori 12 weight portions, Semen Phaseoli 12 weight portions, Rhizoma Imperatae 12 weight portions, Rhizoma Atractylodis 8 weight portions, Cortex Magnoliae Officinalis 8 weight portions, Pericarpium Citri Reticulatae 10 weight portions, Radix Rehmanniae Preparata 10 weight portions, Radix Curcumae 10 weight portions, Rhizoma Zingiberis 20 weight portions, Herba Eupatorii 15 weight portions, Rhizoma Coptidis 6 weight portions, Rhizoma Phragmitis 16 weight portions, Semen Sinapis Albae 18 weight portions, Rhizoma Pinelliae Preparatum 16 weight portions, Herba Taxilli 15 weight portions, Sargassum 10 weight portions, Fructus Lycii 22 weight portions and Semen Plantaginis 20 weight portions.

When the dosage form of described Chinese medicine preparation was granule, its preparation method may further comprise the steps:

Step 1: described raw medicinal material is mixed in described ratio, add determining alcohol with respect to 4~8 times in mixture and be 85%~95% ethanol, be heated to boiling reflux 3~5 hours, filter, adopt percolation with the speed of per minute 1~2ml percolation slowly, collect percolate, relative density is 1.04~1.10 mastic when being evaporated to 50~60 ℃ subsequently under vacuum 0.06~0.09Mpa, spray drying, 160~175 ℃ of the inlet temperature of spray dryer, 80~85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: add with respect to the cane sugar powder of 0.2~0.4 times of dried cream powder quality and 0.1~0.2 times dextrin in the dried cream powder that obtains, granulation in 40~50 ℃ of dryings, obtains granule.

When the dosage form of described Chinese medicine preparation is liniment, its preparation method may further comprise the steps:

Step 1: first described raw medicinal material is ground into coarse powder, further pulverizes, cross 200 mesh sieves, the fine powder amount that enable pass is crossed 200 mesh sieves reaches 60%, and the fine powder of collecting by 200 mesh sieves gets fine powder a;

Step 2: can not drop into multi-function extractor by the coarse powder of 200 mesh sieves and extract twice, and add weight portion 8-10 times of water gaging for the first time and decocted 1-3 hour, and add weight portion 6-10 times of water gaging for the second time and decocted 1-3 hour, and merge decocting liquid twice, and filter to get filtrate; Gained filtrate heating is concentrated into pasty state, put into 80 ℃ of oven dry of baking oven after, the room temperature cooling grinds to form fine powder b;

Step 3: with fine powder a with call in glycerol after fine powder b mixes and make liniment.

The present invention further provides again a kind of preparation method of above-mentioned Chinese medicine preparation, and the dosage form of described Chinese medicine preparation is granule, and it may further comprise the steps:

Step 1: described raw medicinal material is mixed in described ratio, add determining alcohol with respect to 4~8 times in mixture and be 85%~95% ethanol, be heated to boiling reflux 3~5 hours, filter, adopt percolation with the speed of per minute 1~2ml percolation slowly, collect percolate, relative density is 1.04~1.10 mastic when being evaporated to 50~60 ℃ subsequently under vacuum 0.06~0.09Mpa, spray drying, 160~175 ℃ of the inlet temperature of spray dryer, 80~85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: add with respect to the cane sugar powder of 0.2~0.4 times of dried cream powder quality and 0.1~0.2 times dextrin in the dried cream powder that obtains, granulation in 40~50 ℃ of dryings, obtains granule.

The present invention further provides a kind of preparation method of above-mentioned Chinese medicine preparation again, and the dosage form of described Chinese medicine preparation is liniment, and it may further comprise the steps:

Step 1: first described raw medicinal material is ground into coarse powder, further pulverizes, cross 200 mesh sieves, the fine powder amount that enable pass is crossed 200 mesh sieves reaches 60%, and the fine powder of collecting by 200 mesh sieves gets fine powder a;

Step 2: can not drop into multi-function extractor by the coarse powder of 200 solid sieves and extract twice, and add weight portion 8-10 times of water gaging for the first time and decocted 1-3 hour, and add weight portion 6-10 times of water gaging for the second time and decocted 1-3 hour, and merge decocting liquid twice, and filter to get filtrate; Gained filtrate heating is concentrated into pasty state, put into 80 ℃ of oven dry of baking oven after, the room temperature cooling grinds to form fine powder b;

Step 3: with fine powder a with call in glycerol after fine powder b mixes and make liniment.

Beneficial effect of the present invention: Chinese medicine provided by the invention, select the natural Chinese medicines composition fully, do not contain any toxicity and zest or appetite-suppressing and affect the human normal operation, absorb, the material of growth, the normal operation that does not affect human endocrine and the dirty function of internal organs absorbs, harmless, be free from side effects, avirulence, do not need too to go on a diet, as long as suitably note inundue feed, good effect, can transform eliminate superabundant fats and because of the water in the metabolism retention body wet, do not hurt sb.'s feelings body healthy energy and physiological function are weeded out the old and bring forth the new for human body, enhance metabolism, make symmetry and eliminate the interior rubbish of body, do not rebound after the hidden danger that eliminates a disease and the weight reducing.

The specific embodiment

The invention provides a kind of Chinese medicine preparation for fat-reducing, it comprises: the Radix Astragali, Radix Codonopsis, the Radix Paeoniae Alba, Radix Bupleuri, Fructus Crataegi, Massa Medicata Fermentata, Folium Nelumbinis, Fructus Ligustri Lucidi, Radix Sophorae Tonkinensis, Fructus Corni, Semen Pruni, Cortex Mori, Semen Phaseoli, Rhizoma Imperatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, Radix Curcumae, Rhizoma Zingiberis, Herba Eupatorii, Rhizoma Coptidis, Rhizoma Phragmitis, Semen Sinapis Albae, Rhizoma Pinelliae Preparatum, Herba Taxilli, Sargassum, Fructus Lycii and Semen Plantaginis.

Wherein, the pharmacological property of various raw medicinal materials is as follows:

The Radix Astragali: latin name Astragali Radix, sweet in the mouth, warm in nature, enter spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effect of holder skin ulcer granulation promoting cures mainly the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.

Radix Codonopsis: sweet in the mouth, property is flat.Return spleen, lung meridian.The spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.Be used for deficiency of both the splenic and pulmonary QI, the lack of appetite asthenia, the cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry is then grown stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in the vibration, and without just dry fraud.

The Radix Paeoniae Alba: bitter in the mouth, acid, cool in nature, return liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the effect of antiperspirant, cure mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, the diseases such as beneficial woman's blood.

Radix Bupleuri: another name: Asia puecon recklessly, smoke Shennong's Herbal, mountain dish, eat grass " WU Pu Bencao ", faggot " product converge essence want ".Cold nature, bitter in the mouth, suffering; GUIXIN bag, liver, gallbladder, tri-jiao channel.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Be used for fever caused by exogenous pathogens, the diseases such as the internal organs prolapsus of collapse of QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, menoxenia.

Fructus Crataegi: have another name called fruit in the mountain, Fructus Pyri Pashiae, red in the acid, Fructus Pyri Pashiae fruit, Ziziphi Spinosae, Fructus Pyracanthae, red fruit.Sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.

Massa Medicata Fermentata: acrid in the mouth, sweet, warm in nature.Enter spleen, stomach warp.Promoting digestion and removing stagnation, invigorating the spleen and regulating the stomach induces sweat.Cure mainly flu dyspepsia, epigastric distension and distress, dyspepsia, diarrhoea.To general incoordination between the spleen and stomach, get ill from overeating stagnant, infantile malnutrition is also effective in cure.Massa Medicata Fermentata is hot sweet warm in nature, the strong and stomach invigorating of the power that helps digestion and in, be suitable for the disease that various food stagnations do not disappear.

Folium Nelumbinis: bitter in the mouth, puckery, property is flat.Enter the heart, liver, spleen channel.Clearing away heat and removing summer-heat, sending up the lucid YANG, cooling blood for hemostasis.Be used for the summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood is told nosebleed, the metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy removing stasis to stop bleeding.Be used for multiple hemorrhage and puerperal blood faints.

Fructus Ligustri Lucidi: claim again Fructus Ligustri Lucidi reality, Fructus Ilicis Purpureae, white beeswax tree, Mus Chinese catalpa.Sweet in the mouth, hardship, cool in nature; Return liver, kidney channel; The tonifying liver kidney yin, crow must make eye bright.Cure mainly: be used for the hepatic and renal YIN deficiency, soreness of waist ear toot, early whitening of beard and hair; Unseeing, poor vision; Fever due to yin deficiency, gastropathy and gout and and hyperuricemia.

Radix Sophorae Tonkinensis: be the dry root and rhizome of dicotyledon medicine leguminous plant Sophora tonkinensis Gagnep..Hardship, cold; Poisonous.Attach to the lung and stomach meridians.Relieve inflammation or internal heat detoxifcation, detumescence, pain relieving.Cure mainly: control retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, the dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis.

Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, the controlling nocturnal emission with astringent drugs reducing urination, leukorrhagia stopping only collapses, hidroschesis also has promoting the production of body fluid to quench thirst in addition.Be used for soreness of waist and knee joint, dizzy ear toot, forgetful, emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, menoxenia, the profuse sweating collapse, interior-heat is quenched one's thirst.

Semen Pruni: hot, bitter, sweet, flat.Return spleen, large intestine, small intestine meridian.Function cures mainly: moisturize laxation, the therapeutic method to keep the adverse QI flowing downwards, diuretic.Be used for intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, edema, beriberi, dysuria.

Cortex Mori: sweet cold, enter lung meridian.Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for the lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.

Semen Phaseoli: sweet, sour, flat.GUIXIN, small intestine meridian.Inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.Be used for the edema distension, beriberi edema, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.

Rhizoma Imperatae: sweet, cold.Return lung, stomach, urinary bladder channel.Removing heat from blood ends dish, clearing away heat and promoting diuresis.Be used for heat in blood and spit blood epistaxis, hematuria, calentura excessive thirst, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for retention of dampness in middle-JIAO, wind and cold is held wet exterior syndrome under the arm, rheumatic Bi syndrome, distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness; The asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention; Damp-edema; The exterior syndrome folder is wet; Heavy sensation of the body pain; The arthromyodynia warm nature; Podomere is ached and is being weighed; The flaccidity folds in a garment.

Cortex Magnoliae Officinalis: have another name called pachydermia, pipe, magnolia hypoleuca, strong Piao, Cortex Magnoliae Officinalis, CORTEX MAGNOLIAE OFFICINALIS.Bitter in the mouth, suffering; Warm in nature.Return spleen,, large intestine channel.The circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, the gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest is breathed with cough.

Pericarpium Citri Reticulatae: another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.Warm in nature, acrid in the mouth, bitter in the mouth.Enter spleen channel, stomach warp, lung meridian.Regulating qi-flowing for strengthening spleen, in the accent, dampness is reduced phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.Temperature can circulation of qi promoting, and suffering can be dispersed, and is bitter and sluice.

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.The YIN nourishing of enriching blood, beneficial essence is filled out marrow.Be used for blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, and is dizzy, ear toot, chin is sent out early white.

Radix Curcumae: hot, bitter, cold.Return liver, the heart, lung meridian.Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.Be used for the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, the amenorrhea dysmenorrhea, distending pain of the breast, the calentura coma, epilepsy is gone mad, and heat in blood is told nosebleed, the jaundice dark coloured urine.

Rhizoma Zingiberis: suffering, heat.Return spleen, stomach, kidney, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.Be used for coldness and pain in the epigastrium, vomiting is had loose bowels, the cold extremities faint pulse, and cold fluid-retention is breathed with cough.

Herba Eupatorii: suffering, flat.Return spleen, stomach, lung meridian.Removing dampness by means of aromatics, expelling summer-heat is delivered in the appetizing of being amusing.Be used for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouthful, halitosis, sialism, heat-damp in summer exterior syndrome, hygropyrexia be from the beginning of, heating asthenia, uncomfortable in chestly do not relax.

Rhizoma Coptidis: bitter in the mouth, cold in nature, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.

Rhizoma Phragmitis: sweet, cold.Attach to the lung and stomach meridians.Clearing away heat-fire, promoting the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis.Be used for the calentura excessive thirst, cough due to lung-heat, lung abscess vomiting pus, the gastric heat sound of vomiting of vomitting, the puckery pain of pyretic stranguria.

Semen Sinapis Albae: suffering, temperature.Return lung meridian.Warming the lung eliminating phlegm promoting the circulation of QI, the resolving mass and removing the obstruction of the collateral pain relieving.With the cough of sub-cold-phlegm, distending pain in the chest and hypochondrium, the expectorant meridians that stagnate, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.

Rhizoma Pinelliae Preparatum: suffering, temperature.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm.Be used for the abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.

Herba Taxilli: bitter, sweet, flat.Return liver, kidney channel.Wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, antiabortive unit.Be used for rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and the metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement is had a dizzy spell.

Sargassum: bitter, one-tenth, cold.Return liver, stomach, kidney channel.The eliminating phlegm and softening indurated mass eliminating stagnation, inducing diuresis to remove edema.Be used for goiter, scrofula, painful and swollen testis, phlegm retention edema.

Fructus Lycii: sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, dizzy ear toot, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.

Semen Plantaginis: sweet, cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis is treating stranguria, and eliminating dampness by diuresis antidiarrheal makes eye bright, and eliminates the phlegm.Be used for the puckery pain of pyretic stranguria, edema distension, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.

The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably: the Radix Astragali 10~30 weight portions, Radix Codonopsis 10~30 weight portions, the Radix Paeoniae Alba 10~30 weight portions, Radix Bupleuri 10~30 weight portions, Fructus Crataegi 10~20 weight portions, Massa Medicata Fermentata 10~20 weight portions, Folium Nelumbinis 10~20 weight portions, Fructus Ligustri Lucidi 10~20 weight portions, Radix Sophorae Tonkinensis 10~20 weight portions, Fructus Corni 10~15 weight portions, Semen Pruni 10~15 weight portions, Cortex Mori 10~15 weight portions, Semen Phaseoli 10~15 weight portions, Rhizoma Imperatae 10~15 weight portions, Rhizoma Atractylodis 8~12 weight portions, Cortex Magnoliae Officinalis 8~12 weight portions, Pericarpium Citri Reticulatae 8~12 weight portions, Radix Rehmanniae Preparata 8~12 weight portions, Radix Curcumae 8~12 weight portions, Rhizoma Zingiberis 15~25 weight portions, Herba Eupatorii 15~25 weight portions, Rhizoma Coptidis 6~10 weight portions, Rhizoma Phragmitis 15~25 weight portions, Semen Sinapis Albae 15~25 weight portions, Rhizoma Pinelliae Preparatum 15~25 weight portions, Herba Taxilli 15~25 weight portions, Sargassum 8~15 weight portions, Fructus Lycii 15~25 weight portions and Semen Plantaginis 15~25 weight portions.

The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can also be preferably: the Radix Astragali 20~30 weight portions, Radix Codonopsis 20~30 weight portions, the Radix Paeoniae Alba 20~30 weight portions, Radix Bupleuri 20~30 weight portions, Fructus Crataegi 15~20 weight portions, Massa Medicata Fermentata 15~20 weight portions, Folium Nelumbinis 15~20 weight portions, Fructus Ligustri Lucidi 15~20 weight portions, Radix Sophorae Tonkinensis 15~20 weight portions, Fructus Corni 10~12 weight portions, Semen Pruni 10~12 weight portions, Cortex Mori 10~12 weight portions, Semen Phaseoli 10~12 weight portions, Rhizoma Imperatae 10~12 weight portions, Rhizoma Atractylodis 8~10 weight portions, Cortex Magnoliae Officinalis 8~10 weight portions, Pericarpium Citri Reticulatae 8~10 weight portions, Radix Rehmanniae Preparata 8~10 weight portions, Radix Curcumae 8~10 weight portions, Rhizoma Zingiberis 15~20 weight portions, Herba Eupatorii 15~20 weight portions, Rhizoma Coptidis 6~8 weight portions, Rhizoma Phragmitis 15~20 weight portions, Semen Sinapis Albae 15~20 weight portions, Rhizoma Pinelliae Preparatum 15~20 weight portions, Herba Taxilli 15~20 weight portions, Sargassum 8~10 weight portions, Fructus Lycii 20~25 weight portions and Semen Plantaginis 20~25 weight portions.

The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably again: the Radix Astragali 25 weight portions, Radix Codonopsis 25 weight portions, the Radix Paeoniae Alba 25 weight portions, Radix Bupleuri 25 weight portions, Fructus Crataegi 16 weight portions, Massa Medicata Fermentata 16 weight portions, Folium Nelumbinis 16 weight portions, Fructus Ligustri Lucidi 16 weight portions, Radix Sophorae Tonkinensis 16 weight portions, Fructus Corni 10 weight portions, Semen Pruni 10 weight portions, Cortex Mori 12 weight portions, Semen Phaseoli 12 weight portions, Rhizoma Imperatae 12 weight portions, Rhizoma Atractylodis 8 weight portions, Cortex Magnoliae Officinalis 8 weight portions, Pericarpium Citri Reticulatae 10 weight portions, Radix Rehmanniae Preparata 10 weight portions, Radix Curcumae 10 weight portions, Rhizoma Zingiberis 20 weight portions, Herba Eupatorii 15 weight portions, Rhizoma Coptidis 6 weight portions, Rhizoma Phragmitis 16 weight portions, Semen Sinapis Albae 18 weight portions, Rhizoma Pinelliae Preparatum 16 weight portions, Herba Taxilli 15 weight portions, Sargassum 10 weight portions, Fructus Lycii 22 weight portions and Semen Plantaginis 20 weight portions.

The present invention further provides again a kind of preparation method of above-mentioned Chinese medicine preparation, and the dosage form of described Chinese medicine preparation is granule, and it may further comprise the steps:

Step 1: described raw medicinal material is mixed in described ratio, add determining alcohol with respect to 4~8 times in mixture and be 85%~95% ethanol, be heated to boiling reflux 3~5 hours, filter, adopt percolation with the speed of per minute 1~2ml percolation slowly, collect percolate, relative density is 1.04~1.10 mastic when being evaporated to 50~60 ℃ subsequently under vacuum 0.06~0.09Mpa, spray drying, 160~175 ℃ of the inlet temperature of spray dryer, 80~85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: add with respect to the cane sugar powder of 0.2~0.4 times of dried cream powder quality and 0.1~0.2 times dextrin in the dried cream powder that obtains, granulation in 40~50 ℃ of dryings, obtains granule.

The present invention further provides a kind of preparation method of above-mentioned Chinese medicine preparation again, and the dosage form of described Chinese medicine preparation is liniment, and it may further comprise the steps:

Step 1: first described raw medicinal material is ground into coarse powder, further pulverizes, cross 200 mesh sieves, the fine powder amount that enable pass is crossed 200 mesh sieves reaches 60%, and the fine powder of collecting by 200 mesh sieves gets fine powder a;

Step 2: can not drop into multi-function extractor by the coarse powder of 200 mesh sieves and extract twice, and add weight portion 8-10 times of water gaging for the first time and decocted 1-3 hour, and add weight portion 6-10 times of water gaging for the second time and decocted 1-3 hour, and merge decocting liquid twice, and filter to get filtrate; Gained filtrate heating is concentrated into pasty state, put into 80 ℃ of oven dry of baking oven after, the room temperature cooling grinds to form fine powder b;

Step 3: with fine powder a with call in glycerol after fine powder b mixes and make liniment.

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.

Embodiment 1: the granule of the present invention's preparation

Radix Astragali 25g, Radix Codonopsis 25g, Radix Paeoniae Alba 25g, Radix Bupleuri 25g, Fructus Crataegi 16g, Massa Medicata Fermentata 16g, Folium Nelumbinis 16g, Fructus Ligustri Lucidi 16g, Radix Sophorae Tonkinensis 16g, Fructus Corni 10g, Semen Pruni 10g, Cortex Mori 12g, Semen Phaseoli 12g, Rhizoma Imperatae 12g, Rhizoma Atractylodis 8g, Cortex Magnoliae Officinalis 8g, Pericarpium Citri Reticulatae 10g, Radix Rehmanniae Preparata 10g, Radix Curcumae 10g, Rhizoma Zingiberis 20g, Herba Eupatorii 15g, Rhizoma Coptidis 6g, Rhizoma Phragmitis 16g, Semen Sinapis Albae 18g, Rhizoma Pinelliae Preparatum 16g, Herba Taxilli 15g, Sargassum 10g, Fructus Lycii 22g and Semen Plantaginis 20g.

Its preparation method may further comprise the steps:

The dosage form of described Chinese medicine preparation is granule, and it may further comprise the steps:

Step 1: described raw medicinal material is mixed by above-mentioned weight, add determining alcohol with respect to 6 times of mixture weight and be 90% ethanol, be heated to boiling reflux 5 hours, and filtered, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, relative density is 1.10 mastic when being evaporated to 60 ℃ subsequently under vacuum 0.08Mpa, spray drying, 165 ℃ of the inlet temperature of spray dryer, 85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and 0.1 times dextrin in the dried cream powder that obtains, granulation in 50 ℃ of dryings, obtains granule.

Embodiment 2: the granule 2 of the present invention's preparation

Radix Astragali 28g, Radix Codonopsis 28g, Radix Paeoniae Alba 26g, Radix Bupleuri 26g, Fructus Crataegi 15g, Massa Medicata Fermentata 15g, Folium Nelumbinis 15g, Fructus Ligustri Lucidi 15g, Radix Sophorae Tonkinensis 15g, Fructus Corni 11g, Semen Pruni 11g, Cortex Mori 11g, Semen Phaseoli 11g, Rhizoma Imperatae 11g, Rhizoma Atractylodis 9g, Cortex Magnoliae Officinalis 9g, Pericarpium Citri Reticulatae 8g, Radix Rehmanniae Preparata 8g, Radix Curcumae 8g, Rhizoma Zingiberis 18g, Herba Eupatorii 16g, Rhizoma Coptidis 7g, Rhizoma Phragmitis 15g, Semen Sinapis Albae 15g, Rhizoma Pinelliae Preparatum 18g, Herba Taxilli 16g, Sargassum 8g, Fructus Lycii 25g and Semen Plantaginis 21g.

Its preparation method may further comprise the steps:

The dosage form of described Chinese medicine preparation is granule, and it may further comprise the steps:

Step 1: described raw medicinal material is mixed by above-mentioned weight, add determining alcohol with respect to 5 times of mixture weight and be 85% ethanol, be heated to boiling reflux 4 hours, and filtered, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, relative density is 1.06 mastic when being evaporated to 55 ℃ subsequently under vacuum 0.06Mpa, spray drying, 160 ℃ of the inlet temperature of spray dryer, 80 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: add with respect to the cane sugar powder of 0.4 times of dried cream powder quality and 0.2 times dextrin in the dried cream powder that obtains, granulation in 50 ℃ of dryings, obtains granule.

Embodiment 3: the liniment 1 of the present invention's preparation

Radix Astragali 20g, Radix Codonopsis 20g, Radix Paeoniae Alba 20g, Radix Bupleuri 20g, Fructus Crataegi 17g, Massa Medicata Fermentata 17g, Folium Nelumbinis 15g, Fructus Ligustri Lucidi 17g, Radix Sophorae Tonkinensis 16g, Fructus Corni 12g, Semen Pruni 10g, Cortex Mori 12g, Semen Phaseoli 10g, Rhizoma Imperatae 11g, Rhizoma Atractylodis 10g, Cortex Magnoliae Officinalis 8g, Pericarpium Citri Reticulatae 9g, Radix Rehmanniae Preparata 10g, Radix Curcumae 10g, Rhizoma Zingiberis 20g, Herba Eupatorii 17g, Rhizoma Coptidis 8g, Rhizoma Phragmitis 18g, Semen Sinapis Albae 18g, Rhizoma Pinelliae Preparatum 16g, Herba Taxilli 20g, Sargassum 9g, Fructus Lycii 25g and Semen Plantaginis 25g.

Its preparation method may further comprise the steps:

Step 1: first described raw medicinal material is ground into coarse powder, further pulverizes, cross 200 mesh sieves, the fine powder amount that enable pass is crossed 200 mesh sieves reaches 60%, and the fine powder of collecting by 200 mesh sieves gets fine powder a;

Step 2: can not drop into multi-function extractor by the coarse powder of 200 mesh sieves and extract twice, and add 10 times of water gagings of weight portion for the first time and decocted 2 hours, and add 8 times of water gagings of weight portion for the second time and decocted 2 hours, and merge decocting liquid twice, and filter to get filtrate; Gained filtrate heating is concentrated into pasty state, put into 80 ℃ of oven dry of baking oven after, the room temperature cooling grinds to form fine powder b;

Step 3: with fine powder a with call in glycerol after fine powder b mixes and make liniment.

Embodiment 4: the liniment 2 of the present invention's preparation

Radix Astragali 22g, Radix Codonopsis 22g, Radix Paeoniae Alba 26g, Radix Bupleuri 22g, Fructus Crataegi 20g, Massa Medicata Fermentata 20g, Folium Nelumbinis 20g, Fructus Ligustri Lucidi 15g, Radix Sophorae Tonkinensis 18g, Fructus Corni 11g, Semen Pruni 11g, Cortex Mori 12g, Semen Phaseoli 12g, Rhizoma Imperatae 10g, Rhizoma Atractylodis 8g, Cortex Magnoliae Officinalis 9g, Pericarpium Citri Reticulatae 10g, Radix Rehmanniae Preparata 9g, Radix Curcumae 9g, Rhizoma Zingiberis 17g, Herba Eupatorii 15g, Rhizoma Coptidis 6g, Rhizoma Phragmitis 20g, Semen Sinapis Albae 20g, Rhizoma Pinelliae Preparatum 15g, Herba Taxilli 18g, Sargassum 10g, Fructus Lycii 24g and Semen Plantaginis 24g.

Its preparation method may further comprise the steps:

Step 1: first described raw medicinal material is ground into coarse powder, further pulverizes, cross 200 mesh sieves, the fine powder amount that enable pass is crossed 200 mesh sieves reaches 60%, and the fine powder of collecting by 200 mesh sieves gets fine powder a;

Step 2: can not drop into multi-function extractor by the coarse powder of 200 mesh sieves and extract twice, and add 9 times of water gagings of weight portion for the first time and decocted 3 hours, and add 10 times of water gagings of weight portion for the second time and decocted 2 hours, and merge decocting liquid twice, and filter to get filtrate; Gained filtrate heating is concentrated into pasty state, put into 80 ℃ of oven dry of baking oven after, the room temperature cooling grinds to form fine powder b;

Step 3: with fine powder a with call in glycerol after fine powder b mixes and make liniment.

Acute toxicity test

With the granule 1 of the embodiment of the invention 1 preparation and the liniment 1 of embodiment 3 preparations, granule 1 is dissolved in the distilled water,, observes 7 respectively to 2 groups of white mice feeding dispensings or wiping with 150 times of clinical consumption per day and 280 times; All white mice are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

Long term toxicity test

1 pair of mice of granule of the embodiment of the invention 1 preparation is pressed 7.81,18.34 and 40.11g crude drug/kg is dissolved in the water, 1 pair of mice of liniment of the embodiment of the invention 3 preparations is pressed 8.15,19.25 and 40.34g crude drug/kg, to two groups of mices difference 12 weeks of continuous use, every day 2 times, and after 4 weeks of drug withdrawal, the result shows: Chinese medicine of the present invention is to the hair of two groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 12 weeks of medication and 4 weeks of drug withdrawal, Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to the mice long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

Pharmacodynamic experiment

Tested medicine: the granule of Chinese medicine embodiment 1 of the present invention, every heavy 0.5g (every is equivalent to crude drug in whole 40g), clinical dosage is adult 1g (crude drug in whole)/kg.Get 4 of above-mentioned granules, adding distil water is to 100mL, the medicinal liquid that becomes behind the mixing (every 100mL contains crude drug in whole 160g) is for heavy dose of group, and with its equal proportion be diluted to 50%, 25% medicinal liquid respectively in dosage group (every 100mL contains crude drug in whole 80g), small dose group (every 100mL contains crude drug in whole 40g).

Positive control drug: fenfluramine hydrochloride tablets (Tablets Fenfluramine Hy2drochloride, TFH), specification: every hydrochloric fenfluramine 20mg.Clinical dosage is each 1, every day 3 times.Baoshan Pharmaceutical Factory, Yadong medicine Corp., Shanghai medicine Industr's product, Shanghai are defended the accurate word (1995) 035001 of medicine, lot number 970111.

The preparation: get the TFH100mg adding distil water to 100mL, behind the mixing 0.1% medicinal liquid for the fenfluramine group.

Animal subject: test with weanling SD rat, male and female half and half, totally 60, body weight 50~55g is provided by Jiangsu Province's antibiotic industrial research institute animal center, and is for subsequent use after the quarantine.

1.3 reagent

Cholesterol (CHO) is measured test kit (CHOD2PAP method), lot number: 960724; Triglyceride (TG) is measured test kit (GPO2POD method), lot number: 960722; High density lipoprotein (HDL) test kit (Cholestero12HDL method), lot number: 961031.More than be Beijing Chemical Plant clinical reagent subsidiary factory product.

1.4 instrument

Japan Shimadzu UV2730 automatic biochemical colour comparatour; Japan's Tianjin field EB23200D precise electronic balance (precision 0.1g).

1.5 feedstuff

Normal diet: Fructus Hordei Vulgaris powder 20%, dehydrated vegetable (removing the cabbage of moisture) 10%, Semen Glycines powder 20%, yeast 1%, Semen Maydis powder 16%, wheat bran 16%, fish flour 10%, Sal 2%.

Nutrient fodder: add milk powder 10g, Adeps Sus domestica 10g, 1 in egg, Concentrated Cod-liver Oil an amount of (containing retinol1 7000U, vitamin D1 1700U), fresh Semen Glycines Germinatus 250g in the 100g normal diet.

2. method

2.1 modeling and grouping

The SD rat is divided into 6 groups of Normal group, model control group, high, medium and low 3 the dosage groups of traditional Chinese medicine capable of reducing weight granule of the present invention (be equivalent to respectively clinical recommended dose 20 times, 10 times, 5 times) and positive western medicine group (be equivalent to clinical recommended dose 10 times) etc. at random by body weight.The normal control treated animal is fed and is given normal diet, and all the other each groups are all fed and given nutrient fodder.The amount of supply feedstuff is every Mus 13g every day in the 1st, 2 weeks, increases weekly later on 2g, to ending in the 6th week.Every day, feedstuff divided 2 supplies, no longer added after eating up; Behind the feed 45 days, nearly 1 times of the rat increase of the same age that body weight is fed than normal diet.

2.2 administration time and method

Adopt not isoconcentration administering medical liquids of isometric(al), gavage volume 10mL/kg.Every day, gavage was 1 time, continuous 4 weeks, weigh weekly 1 time, and adjust nutrient fodder amount and dosage according to body weight.

2.3 evaluation index

(1) body weight and Lee ' s exponential quantity are measured: before the execution, Measurement accuracy body long (length from nose to anus) then calculates Lee ' s index value under anesthesia.Computing formula: Lee ' s index=[body weight (g) * 103] 1/3/ body long (cm).(2) around the kidney, abdominal cavity fat gravimetry: after the blood-letting, cut open respectively and get around the kidney and the whole fat of intraperitoneal, take by weighing weight in wet base.(3) biochemical measurement: serum total cholesterol, triglyceride, high density lipoprotein, glucose.

2.4 statistical method

Adopt on computers SPSS to carry out statistical disposition, measurement data represents with .x ± s.Experimental result adopts model group and blank group to compare, and each administration group and model group compare in twos.

3 results

3.1 traditional Chinese medicine capable of reducing weight granule of the present invention is on the impact (seeing Table 1) of experimental mouse body weight

Table 1 Chinese medicine compound fat-reducing granule is on the impact of experimental mouse body weight (.x ± s)

Compare ##P<0.01 with Normal group; Compare * P<0.05 with model control group

As can be seen from Table 1, traditional Chinese medicine capable of reducing weight granule administration group body weight and model group relatively have attenuating trend, and wherein dosage group body weight and model group comparison in the traditional Chinese medicine capable of reducing weight granule (when the 7th, the 8th week) has significant difference (P<0.05).

3.2 the traditional Chinese medicine capable of reducing weight granule is to test Mus Lee ' s exponential sum fat weight in wet base

The impact of index (seeing Table 2)

Table 2 traditional Chinese medicine capable of reducing weight granule is on the impact of test Mus Lee ' s exponential sum fat weight in wet base index (x ± s)

Group n Dosage (g/kg) Lee ' s exponential quantity Fat weight in wet base (g/100g) Normal group 10 / 307.7±7.6 2.1±0.6 The obese model group 10 / 318.6±7.8 4.5±1.1 Positive controls 10 10mg/kg 299.4±21.85 2.4±0.8 Low dose group 10 50 307.5±9.8l 2.7±1.0 Middle dosage group 10 100 311.6±7.67 2.7±0.8l High dose group 10 200 308.4±15.7 2.8±1.0

Compare ##P<0.01 with Normal group; Compare * * P<0.01 with model control group

As can be seen from Table 2, traditional Chinese medicine capable of reducing weight granule administration group Lee ' s index has been compared reduction trend with model group, and wherein traditional Chinese medicine capable of reducing weight granule low dose group Lee ' s exponential quantity and model group relatively have utmost point significant difference (P<0.01).3 dosage group fat weight in wet base indexes of traditional Chinese medicine capable of reducing weight granule and model group more all have utmost point significant difference (P<0.01).

3.3 the traditional Chinese medicine capable of reducing weight granule is on the impact (seeing Table 3) of test Mus blood Cho, TG, HDL2C and GLU level

Table 3 traditional Chinese medicine capable of reducing weight granule is on the impact of Cho, TG, HDL2C, GLU level in the test Mus blood (.x ± s)

Compare ##P<0.01 with Normal group; Compare with model control group: * P<0.05, * * P<0.01

As can be seen from Table 3, traditional Chinese medicine capable of reducing weight granule administration group Cho of the present invention, TG, GLU and model group relatively have reduction trend, and wherein traditional Chinese medicine capable of reducing weight granule high dose group Cho of the present invention and model group relatively have significant difference (P<0.05); Traditional Chinese medicine capable of reducing weight granule 3 dosage groups TG of the present invention and model group relatively have utmost point significant difference (P<0.01); This traditional Chinese medicine capable of reducing weight granule low dose group GLU and model group relatively have utmost point significant difference (P<0.01), and fat-reducing granule high dose group GLU of the present invention and model group relatively have significant difference (P<0.05); Traditional Chinese medicine capable of reducing weight granule administration group HDL2C of the present invention and model group relatively have increase trend, and wherein traditional Chinese medicine capable of reducing weight granule low dose group HDL2C of the present invention and model group relatively have significant difference (P<0.05).

The traditional Chinese medicine capable of reducing weight medicine of the present invention of can reaching a conclusion thus has obvious fat-reducing effect.

Clinical trial

Get 100 routine patients, male 64 examples, women 36 examples, 39 years old mean age, are got rid of Secondary Obesity and are Simple Obesity, Body Mass Index (BMI) 〉=25Kg/m age 22-61 year.100 routine patients are divided into treatment group and matched group at random, every group of 50 examples.Two groups of ages, sex, BMI learn processing by statistics, without significant difference, have comparability (P>0.05)

Test method: be divided into treatment phase and observation period.Treatment phase Therapeutic Method: treatment group oral Chinese medicinal composition granules 1 of the present invention ante cibum, every day 2 times, each 2-4 grain, 2 months courses for the treatment of.Matched group is drug administration not.Two groups all stop to drink, stopping drinking sugary soda pop, stop strenuous exercise, suitably the amount of keeping on a diet.Respectively detect body weight one time with the centre before and after the treatment.Normally whether to observe spirit, sleep, symptom, defecation during the treatment.Observation period: the time is treatment after date 6 months, the object of observation for treatment during produce effects and effective patient, respectively detect body weight one time with the centre before and after the observation period, normally whether observe simultaneously spirit, sleep, symptom, defecation.

Treatment phase criterion of therapeutical effect: produce effects: weight loss is the person more than 10 kilograms; Effectively: weight loss person more than 5 kilograms; Invalid: weight loss is not above 3 kilograms.

The result: treatment group produce effects 76 examples (76%), effective 19 examples (19%), invalid 5 examples (5%), total effective rate is 95%.Effective 12 examples of matched group (12%), invalid 88 examples (88%).Learn by statistics processing for two groups, have significant difference (P>0.01).

During the treatment, the patient has no untoward reaction, without diarrhoea and uncomfortable.

Observation period criterion of therapeutical effect: produce effects: body weight rising person below 2 kilograms; Effectively: the body weight 2-5 kilogram person that risen; Invalid: body weight rises above 5 kilograms.

The result: treatment group is totally 85 people, produce effects 79 examples (92.9%), and effective 5 examples (5.9%), invalid 1 example (1.2%), total effective rate is 98.8%.Matched group is totally 12 people, effective 1 example (8.3%), invalid 11 examples (91.7%).Learn by statistics processing for two groups, have significant difference (P>0.01).

Viewing duration, the patient has no untoward reaction, without diarrhoea and uncomfortable.

In sum, slimming medicine of the present invention can help patient's quick weight-lossing in a short time, and is difficult for bounce-back after the fat-reducing.

Model case 1: patient Wang, man, 38 years old, 122 kilograms.Disease sees that deficiency of vital energy lazyness uncomfortable in chest, drowsiness is moving, tongue in vain greasy, enlarged tongue, rolling pulse, uses the granule 1 of the embodiment 1 of Chinese medicine of the present invention, every day 2 times, each 4.Medication 20 days, waistline obviously reduces, and overall variation is very large, continues medication two months, weight loss to 87 kilogram, abdominal part distension once, tenderness, the foot that can't see oneself that abdominal part is large, health is heavy, transference cure after the medication, and weight reducing is a lot, and the mental status is very good.Follow up a case by regular visits to not recurrence in 2 years.

Model case 2: patient Zhang, the woman 30 years old, 116 kilograms, examines and sees fat hold concurrently stagnation of QI due to depression of the liver or blood stasis person.Disease sees that obesity has hypochondriac pain, irritability, dizzy, asthenia, abdominal distention, yellow fur, stringy pulse concurrently, uses the liniment 1 of the embodiment 3 of Chinese medicine of the present invention, is applied in the athero position every day, and is massaged into till the skin heating one day three times.Effect: after the use, the skin of abdomen fold reduces, and becomes moist, and abdominal part has the heating sense, and all temperatures of umbilicus are obvious, the attenuation of sensation stomach fat, and proud flesh reduces, and abdominal part flattens smooth, and abdominal distention disappears, free movement of the bowels, the intestines and stomach coordinating functional effect is obvious, and sleep is well.Use after three months weight recovery to 68 kilogram.Follow up a case by regular visits to not recurrence in 1 year half.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims (8)

1. Chinese medicine preparation that is used for fat-reducing, it is characterized in that, comprise following raw medicinal material in the described Chinese medicine preparation: the Radix Astragali, Radix Codonopsis, the Radix Paeoniae Alba, Radix Bupleuri, Fructus Crataegi, Massa Medicata Fermentata, Folium Nelumbinis, Fructus Ligustri Lucidi, Radix Sophorae Tonkinensis, Fructus Corni, Semen Pruni, Cortex Mori, Semen Phaseoli, Rhizoma Imperatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, Radix Curcumae, Rhizoma Zingiberis, Herba Eupatorii, Rhizoma Coptidis, Rhizoma Phragmitis, Semen Sinapis Albae, Rhizoma Pinelliae Preparatum, Herba Taxilli, Sargassum, Fructus Lycii and Semen Plantaginis.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine preparation is: the Radix Astragali 10~30 weight portions, Radix Codonopsis 10~30 weight portions, the Radix Paeoniae Alba 10~30 weight portions, Radix Bupleuri 10~30 weight portions, Fructus Crataegi 10~20 weight portions, Massa Medicata Fermentata 10~20 weight portions, Folium Nelumbinis 10~20 weight portions, Fructus Ligustri Lucidi 10~20 weight portions, Radix Sophorae Tonkinensis 10~20 weight portions, Fructus Corni 10~15 weight portions, Semen Pruni 10~15 weight portions, Cortex Mori 10~15 weight portions, Semen Phaseoli 10~15 weight portions, Rhizoma Imperatae 10~15 weight portions, Rhizoma Atractylodis 8~12 weight portions, Cortex Magnoliae Officinalis 8~12 weight portions, Pericarpium Citri Reticulatae 8~12 weight portions, Radix Rehmanniae Preparata 8~12 weight portions, Radix Curcumae 8~12 weight portions, Rhizoma Zingiberis 15~25 weight portions, Herba Eupatorii 15~25 weight portions, Rhizoma Coptidis 6~10 weight portions, Rhizoma Phragmitis 15~25 weight portions, Semen Sinapis Albae 15~25 weight portions, Rhizoma Pinelliae Preparatum 15~25 weight portions, Herba Taxilli 15~25 weight portions, Sargassum 8~15 weight portions, Fructus Lycii 15~25 weight portions and Semen Plantaginis 15~25 weight portions.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine preparation is: the Radix Astragali 20~30 weight portions, Radix Codonopsis 20~30 weight portions, the Radix Paeoniae Alba 20~30 weight portions, Radix Bupleuri 20~30 weight portions, Fructus Crataegi 15~20 weight portions, Massa Medicata Fermentata 15~20 weight portions, Folium Nelumbinis 15~20 weight portions, Fructus Ligustri Lucidi 15~20 weight portions, Radix Sophorae Tonkinensis 15~20 weight portions, Fructus Corni 10~12 weight portions, Semen Pruni 10~12 weight portions, Cortex Mori 10~12 weight portions, Semen Phaseoli 10~12 weight portions, Rhizoma Imperatae 10~12 weight portions, Rhizoma Atractylodis 8~10 weight portions, Cortex Magnoliae Officinalis 8~10 weight portions, Pericarpium Citri Reticulatae 8~10 weight portions, Radix Rehmanniae Preparata 8~10 weight portions, Radix Curcumae 8~10 weight portions, Rhizoma Zingiberis 15~20 weight portions, Herba Eupatorii 15~20 weight portions, Rhizoma Coptidis 6~8 weight portions, Rhizoma Phragmitis 15~20 weight portions, Semen Sinapis Albae 15~20 weight portions, Rhizoma Pinelliae Preparatum 15~20 weight portions, Herba Taxilli 15~20 weight portions, Sargassum 8~10 weight portions, structure Fructus Lycii 20~25 weight portions and Semen Plantaginis 20~25 weight portions.
4. such as the described Chinese medicine preparation of claims 1 to 3, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine preparation is: the Radix Astragali 25 weight portions, Radix Codonopsis 25 weight portions, the Radix Paeoniae Alba 25 weight portions, Radix Bupleuri 25 weight portions, Fructus Crataegi 16 weight portions, Massa Medicata Fermentata 16 weight portions, Folium Nelumbinis 16 weight portions, Fructus Ligustri Lucidi 16 weight portions, Radix Sophorae Tonkinensis 16 weight portions, Fructus Corni 10 weight portions, Semen Pruni 10 weight portions, Cortex Mori 12 weight portions, Semen Phaseoli 12 weight portions, Rhizoma Imperatae 12 weight portions, Rhizoma Atractylodis 8 weight portions, Cortex Magnoliae Officinalis 8 weight portions, Pericarpium Citri Reticulatae 10 weight portions, Radix Rehmanniae Preparata 10 weight portions, Radix Curcumae 10 weight portions, Rhizoma Zingiberis 20 weight portions, Herba Eupatorii 15 weight portions, Rhizoma Coptidis 6 weight portions, Rhizoma Phragmitis 16 weight portions, Semen Sinapis Albae 18 weight portions, Rhizoma Pinelliae Preparatum 16 weight portions, Herba Taxilli 15 weight portions, Sargassum 10 weight portions, Fructus Lycii 22 weight portions and Semen Plantaginis 20 weight portions.
5. such as the described Chinese medicine preparation of claim 1 to 4, it is characterized in that, when the dosage form of described Chinese medicine preparation was granule, its preparation method may further comprise the steps:
Step 1: described raw medicinal material is mixed in described ratio, add determining alcohol with respect to 4~8 times in mixture and be 85%~95% ethanol, be heated to boiling reflux 3~5 hours, filter, adopt percolation with the speed of per minute 1~2ml percolation slowly, collect percolate, relative density is 1.04~1.10 mastic when being evaporated to 50~60 ℃ subsequently under vacuum 0.06~0.09Mpa, spray drying, 160~175 ℃ of the inlet temperature of spray dryer, 80~85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;
Step 2: add with respect to the cane sugar powder of 0.2~0.4 times of dried cream powder quality and 0.1~0.2 times dextrin in the dried cream powder that obtains, granulation in 40~50 ℃ of dryings, obtains granule.
6. such as the described Chinese medicine preparation of claim 1 to 5, it is characterized in that: when the dosage form of described Chinese medicine preparation is liniment, its preparation method may further comprise the steps:
Step 1: first described raw medicinal material is ground into coarse powder, further pulverizes, cross 200 mesh sieves, the fine powder amount that enable pass is crossed 200 mesh sieves reaches 60%, and the fine powder of collecting by 200 mesh sieves gets fine powder a;
Step 2: can not drop into multi-function extractor by the coarse powder of 200 mesh sieves and extract twice, and add weight portion 8-10 times of water gaging for the first time and decocted 1-3 hour, and add weight portion 6-10 times of water gaging for the second time and decocted 1-3 hour, and merge decocting liquid twice, and filter to get filtrate; Gained filtrate heating is concentrated into pasty state, put into 80 ℃ of oven dry of baking oven after, the room temperature cooling grinds to form fine powder b;
Step 3: with fine powder a with call in glycerol after fine powder b mixes and make liniment.
7. preparation method such as the described Chinese medicine preparation of claim 1 to 6, it is characterized in that: the dosage form of described Chinese medicine preparation is granule, and it may further comprise the steps:
Step 1: described raw medicinal material is mixed in described ratio, add determining alcohol with respect to 4~8 times in mixture and be 85%~95% ethanol, be heated to boiling reflux 3~5 hours, filter, adopt percolation with the speed of per minute 1~2ml percolation slowly, collect percolate, relative density is 1.04~1.10 mastic when being evaporated to 50~60 ℃ subsequently under vacuum 0.06~0.09Mpa, spray drying, 160~175 ℃ of the inlet temperature of spray dryer, 80~85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;
Step 2: add with respect to the cane sugar powder of 0.2~0.4 times of dried cream powder quality and 0.1~0.2 times dextrin in the dried cream powder that obtains, granulation in 40~50 ℃ of dryings, obtains granule.
8. such as the preparation method of the described Chinese medicine preparation of claim 1 to 6, it is characterized in that: the dosage form of described Chinese medicine preparation is liniment, and it may further comprise the steps:
Step 1: first described raw medicinal material is ground into coarse powder, further pulverizes, cross 200 mesh sieves, the fine powder amount that enable pass is crossed 200 mesh sieves reaches 60%, and the fine powder of collecting by 200 mesh sieves gets fine powder a;
Step 2: can not drop into multi-function extractor by the coarse powder of 200 mesh sieves and extract twice, and add weight portion 8-10 times of water gaging for the first time and decocted 1-3 hour, and add weight portion 6-10 times of water gaging for the second time and decocted 1-3 hour, and merge decocting liquid twice, and filter to get filtrate; Gained filtrate heating is concentrated into pasty state, put into 80 ℃ of oven dry of baking oven after, the room temperature cooling grinds to form fine powder b;
Step 3: with fine powder a with call in glycerol after fine powder b mixes and make liniment.
CN201210414576.3A 2012-10-15 2012-10-15 Traditional Chinese medicine preparation for losing weight and preparation method of traditional Chinese medicine preparation CN102886038B (en)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103301436A (en) * 2013-06-21 2013-09-18 王燕华 Medicine for loosing weight and reducing fat
CN103721127A (en) * 2013-12-10 2014-04-16 河南孟诜堂药业有限公司 Beauty and sliming tea and preparation method thereof
CN103734424A (en) * 2013-12-30 2014-04-23 青岛恒波仪器有限公司 Tartary buckwheat tea capable of losing weight, reducing lipid and relaxing bowels, and preparation method of tea
CN103877204A (en) * 2014-04-19 2014-06-25 陈晓霞 Chinese traditional medicine oral liquid for treating obesity and preparation method of oral liquid
CN104351563A (en) * 2014-11-27 2015-02-18 山东新希望六和集团有限公司 Functional feed used for preventing pig malignant edema and preparation method of functional feed
CN104435973A (en) * 2014-11-11 2015-03-25 覃海兰 Traditional Chinese medicine formula for losing weight
CN104547958A (en) * 2015-02-09 2015-04-29 王士国 Traditional Chinese medicine preparation with effects of promoting digestion and reducing lipid and preparation method
CN104623414A (en) * 2015-02-05 2015-05-20 刘蔚 Traditional Chinese medicine composition for treating nutritional obesity
CN105267730A (en) * 2015-02-12 2016-01-27 济南舜景医药科技有限公司 External traditional Chinese medicine composition for treating obesity
CN106620516A (en) * 2016-12-07 2017-05-10 庞秀军 Traditional Chinese medicine composition used for health maintenance and weight loss as well as preparation and preparation method thereof
CN107348286A (en) * 2017-08-23 2017-11-17 宁波甬基生物科技有限公司 A kind of fat lotus leaf eupatorium health beverages and preparation method thereof that disappear of reducing weight

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101485865A (en) * 2009-02-11 2009-07-22 白云沂 Chinese medicine fat-reducing plaster
CN101632810A (en) * 2009-06-17 2010-01-27 戴瑞萍 Weight-reducing capsule
CN101966294A (en) * 2010-11-05 2011-02-09 佟玲 External traditional Chinese medicine for slimming

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101485865A (en) * 2009-02-11 2009-07-22 白云沂 Chinese medicine fat-reducing plaster
CN101632810A (en) * 2009-06-17 2010-01-27 戴瑞萍 Weight-reducing capsule
CN101966294A (en) * 2010-11-05 2011-02-09 佟玲 External traditional Chinese medicine for slimming

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103301436A (en) * 2013-06-21 2013-09-18 王燕华 Medicine for loosing weight and reducing fat
CN103721127A (en) * 2013-12-10 2014-04-16 河南孟诜堂药业有限公司 Beauty and sliming tea and preparation method thereof
CN103734424A (en) * 2013-12-30 2014-04-23 青岛恒波仪器有限公司 Tartary buckwheat tea capable of losing weight, reducing lipid and relaxing bowels, and preparation method of tea
CN103877204A (en) * 2014-04-19 2014-06-25 陈晓霞 Chinese traditional medicine oral liquid for treating obesity and preparation method of oral liquid
CN103877204B (en) * 2014-04-19 2015-10-21 陈晓霞 A kind of Chinese medicine oral liquid and preparation method for the treatment of obesity
CN104435973A (en) * 2014-11-11 2015-03-25 覃海兰 Traditional Chinese medicine formula for losing weight
CN104351563A (en) * 2014-11-27 2015-02-18 山东新希望六和集团有限公司 Functional feed used for preventing pig malignant edema and preparation method of functional feed
CN104623414A (en) * 2015-02-05 2015-05-20 刘蔚 Traditional Chinese medicine composition for treating nutritional obesity
CN104547958A (en) * 2015-02-09 2015-04-29 王士国 Traditional Chinese medicine preparation with effects of promoting digestion and reducing lipid and preparation method
CN105267730A (en) * 2015-02-12 2016-01-27 济南舜景医药科技有限公司 External traditional Chinese medicine composition for treating obesity
CN106620516A (en) * 2016-12-07 2017-05-10 庞秀军 Traditional Chinese medicine composition used for health maintenance and weight loss as well as preparation and preparation method thereof
CN107348286A (en) * 2017-08-23 2017-11-17 宁波甬基生物科技有限公司 A kind of fat lotus leaf eupatorium health beverages and preparation method thereof that disappear of reducing weight

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