CN105770920B - A kind of pharmaceutical preparation and its application for stomach and intestine color ultrasound assistant - Google Patents

A kind of pharmaceutical preparation and its application for stomach and intestine color ultrasound assistant Download PDF

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CN105770920B
CN105770920B CN201610213438.7A CN201610213438A CN105770920B CN 105770920 B CN105770920 B CN 105770920B CN 201610213438 A CN201610213438 A CN 201610213438A CN 105770920 B CN105770920 B CN 105770920B
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parts
pharmaceutical preparation
stomach
assistant
grams
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CN105770920A (en
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李雷
徐涛
邱发龙
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Qingdao Central Hospital
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Abstract

The present invention relates to a kind of pharmaceutical preparations and application thereof for stomach and intestine color ultrasound assistant, and parts by weight are contained in prescription are as follows: 10-20 parts of egg shell, 10-18 parts of jujube, 8-14 parts of FRUCTUS CITRI AURANTII AMARAE, 5-12 parts of green peel, 3-8 parts of paniculate swallowwort, 7-14 parts of eupatorium, 8-14 parts of mother-of-pearl, 6-10 parts of Caulis Kadsurae, 5-12 parts of mountain Cape jasmine, 4-11 parts of Herba Hyperici Monogyni, 13-17 parts of Radix Codonopsis, 6-13 parts of levant cotton exocarp, 7-13 parts of malt.Pharmaceutical preparation of the present invention both can be used as assistant use, the drug that can be used as treatment gastric ulcer again uses, it is used as assistant, it is easy to use, good in taste, the image clearly of formation, dotted strong reecho, stomach wall clear layer is visible, gastric ulcer definite effect is treated, there is small dosage, short treating period, cure rate height, it is without side-effects.

Description

A kind of pharmaceutical preparation and its application for stomach and intestine color ultrasound assistant
Technical field
The invention belongs to field of medicaments more particularly to a kind of pharmaceutical preparations and its application for stomach and intestine color ultrasound assistant.
Background technique
Contrast agent (also known as contrast medium, contrastmedia) is to inject (or taking) for enhancing Imaging Study effect and arrive The chemicals of tissue or organ.The density of these products is higher or lower than surrounding tissue, the certain devices of comparison of formation Tool shows image.The common Operand of such as x-ray observation, barium sulfate.
Ultrasonic image diagnosis is one of important diagnostic method in medicine.Ultrasonic wave has three big effects to substance: first is that mechanical Effect often makes material particle make high-frequency mechanical oscillation since ultrasonic energy is huge, thus generates and smash, agglomerate, stirring Effect.Second is that warm-heat effect, when ultrasonic wave acts on substance, energy is absorbed by substance, thus it is existing to increase mass temperature As.Third is that cavitation, when ultrasonic wave is acted on liquid, the region (if any microscopic bubble etc.) of liquid internal stress weakness by Become sparse in acoustic pressure great variety, at this moment under surrounding liquid molecule pulling force effect, forms a small cavity, it is as empty Change effect.
Since human intestines and stomach belongs to hollow organ, under normal circumstances, stomach wall level cannot be shown well using color ultrasound.It helps The use of shadow agent can make full form, gastral cavity size, stomach wall level, emptying time and the stomach that can show stomach well of gastral cavity Diseased region, while can also show the lesion situation of small intestine and colon.Chinese medicine has incomparable as traditional motherland's medicine Advantage.
Chinese medicine composition gradually gets up extensively as the application of assistant at present, such as Chinese invention patent application number: 01128137.5 provides one kind for color gastrointestinal ultrasonic contrast medium, by 1 part of pearl, 1 part of the shell of seaear, 1 part of cuttlebone, bletilla 1 part of composition, can clarify a diagnosis human body gastritis, gastric ulcer, gastric cancer, gastroptosis, prolapse of gastric mucosa, duodenal bulbar inflammation, 12 The diseases such as cancerous swelling at duodenum 12 duodenobulbar ulcer, in the morning, afternoon and evening phase stomach and intestine tumor, esophagus upper-lower section and cardia.
Chinese invention patent application number 200810238127.1 discloses a kind of Chinese medicine assistant that B ultrasound uses and its preparation Method, assistant include the various raw materials of following portions by weight ratio: 10~20 parts of the shell of seaear, 10~20 parts of concha mauritiae, and Divine Comedy 10~20 parts, 10~20 parts of Radix Codonopsis, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 10~20 parts of Poria cocos, 10~20 parts of the bletilla striata, 10~20 parts of field pennycress, 10~20 parts of the root of three-nerved spicebush, 10~20 parts of radix aucklandiae.
Chinese invention patent application number 201210364551.7 has supplied a kind of Chinese medicine stomach and intestine assistant and its system for B ultrasound Preparation Method includes following raw medicinal material in Chinese medicine: fennel seeds, galangal, rhizoma cyperi, the root of three-nerved spicebush, cuttlebone, green peel, Divine Comedy, malt, The dried immature fruit of citron orange, rheum officinale, saltcake, Cortex Magnoliae Officinalis, radix aucklandiae, fructus amomi, wrinkled giant hyssop, fingered citron, hawthorn, radish, calcined CONCHA ARCAE, evodia rutaecarpa, the tuber of pinellia, Bin Bulky, Rhizoma Atractylodis Macrocephalae, rhizoma nardostachyos and fritillaria thunbergii.
A kind of gastrointestinal tract contrast medium of Chinese patent CN201510487240, it is disclosed that 50~70 parts of barium sulfate, Chinese medicine 25~35 parts of extract, 50~80 parts of honey and 300~500 parts of water；Wherein Chinese medical extract prepared by following Chinese medicine material and At: tiger pierce 20~30 parts, hook 20~30 parts of catechu, native 20~30 parts of the root of straight ladybell, 10~15 parts of white residual flower, 10~15 parts of the tuber of pinellia, 10~15 parts of red yeast rice, 10~15 parts of incisory spleenwort herb, 10~15 parts of fresh rehmannia root, 10~15 parts of the Fructus Sophorae, 10~15 parts of the bletilla striata, Radix Astragali 5~ 10 parts, 5~10 parts of radix bupleuri, gastrointestinal peristalsis is too fast, auxiliary barium meal is swallowed, nourish gastrointestinal tract and stomach is inhibited to go out with inhibiting by the present invention The advantages of blood.
Currently used assistant is mainly barium sulfate and Operand, and so existing research is it has been confirmed that existing assistant is used Amount is the independent hazard factor for causing assistant nephrosis.Furthermore assistant patient nettle can also be caused to examine, angioedema, larynx The idiosyncratic reactions such as cephaledema, bronchial spasm, the decline of serious blood pressure and die by visitation of God.This kind of assistant increases to gastrointestinal tract simultaneously Add additional burden, increases the pain of patient.
Summary of the invention
In view of the drawbacks of the prior art, the status that the present invention be directed to treat at present provides one kind and helps for stomach and intestine color ultrasound The pharmaceutical preparation of shadow agent and its application., and have no toxic side effect, effect is good.
Specifically, concrete scheme of the invention is achieved in that
Firstly, inventor provides a kind of pharmaceutical preparation for stomach and intestine color ultrasound assistant according to drug matching experience, place The traditional Chinese medicine ingredients contained in side are as follows: egg shell, jujube, FRUCTUS CITRI AURANTII AMARAE, green peel, paniculate swallowwort, eupatorium, mother-of-pearl, Caulis Kadsurae, Mountain Cape jasmine, Herba Hyperici Monogyni, Radix Codonopsis, levant cotton exocarp, malt.
Further, inventor provides a kind of pharmaceutical preparation for stomach and intestine color ultrasound assistant according to drug matching experience, Each raw material dosage of prescription all has having a better effect, the formula and parts by weight in parts by weight range of the invention are as follows: 10-20 parts of egg shell, 10-18 parts of jujube, 8-14 parts of FRUCTUS CITRI AURANTII AMARAE, 5-12 parts of green peel, 3-8 parts of paniculate swallowwort, 7-14 parts of eupatorium, 8-14 parts of mother-of-pearl, 6-10 parts of Caulis Kadsurae, 5-12 parts of mountain Cape jasmine, 4-11 parts of Herba Hyperici Monogyni, 13-17 parts of Radix Codonopsis, levant cotton exocarp 6- 13 parts, 7-13 parts of malt.
The formula of above-mentioned parts by weight is carried out preferably, to reach superior technique effect, it is preferred to be formulated are as follows: egg shell 15 Part, 14 parts of jujube, 11 parts of FRUCTUS CITRI AURANTII AMARAE, 8.5 parts of green peel, 6 parts of paniculate swallowwort, 11 parts of eupatorium, 11 parts of mother-of-pearl, Caulis Kadsurae 8 Part, 9 parts of mountain Cape jasmine, 7.5 parts of Herba Hyperici Monogyni, 15 parts of Radix Codonopsis, 10.5 parts of levant cotton exocarp, 10 parts of malt.
Or:
14 parts of egg shell, 12 parts of jujube, 10 parts of FRUCTUS CITRI AURANTII AMARAE, 7.5 parts of green peel, 6 parts of paniculate swallowwort, 10 parts of eupatorium, pearl Female 10 parts, 9 parts of Yunnan chicken blood, 9 parts of mountain Cape jasmine, 6.5 parts of Herba Hyperici Monogyni, 14 parts of Radix Codonopsis, 10.5 parts of levant cotton exocarp, 9 parts of malt.
In pharmaceutical preparation described above, used Chinese medicine commonly uses medicinal part using it and is used as medicine, it is used in Pharmaceutical quantities are reasonable, for having preferable effect for gastrointestinal contrast agent after all medicines share.
The function of each taste Chinese medicine used in the pharmaceutical preparation for the treatment of of the invention is as follows:
Egg shell: it is lightly seasoned, it is mild-natured.
Major function: convergence relieving haperacidity, replenishes the calcium.For chronic gastritis, gastric and duodenal ulcer, rickets.
Jujube: it is sweet in flavor, it is warm-natured.
Channel tropism: returns spleen, stomach meridian.
Major function: tonifying middle-Jiao and Qi, nourishing blood and tranquilization are used for spleen eating less, loose stool out of strength.
FRUCTUS CITRI AURANTII AMARAE: it is cold in nature, it is sour.
Major function: ventilating, helps digestion, resolving sputum.For the bored distending pain of chest and abdomen, accumulation of food in the stomach and intes tine due to indigestion, phlegm retention, rectal prolapse.
Green peel: bitter, it is warm-natured.
Channel tropism: return liver, gallbladder, stomach meridian.
Major function: soothing the liver relieving stagnant Qi, disperse accumulationization are stagnant.For distending pain in the chest and hypochondrium, hernia, newborn core, acute mastitis, dyspeptic abdominalgia.
Paniculate swallowwort: acrid flavour, it is warm-natured.
Channel tropism: return liver, stomach meridian.
Major function: wind-dispelling dampness elimination, antalgesic-antipruritic.For rheumatic arthralgia, turgor of having a stomachache, toothache, pain in the loins, injury from falling down, Nettle rash, eczema.
Eupatorium: acrid flavour, it is mild-natured.
Channel tropism: returns spleen, stomach, lung channel.
Major function: removing dampness by means of aromatics, appetizing of being amusing delivers relieving summer-heat.For turbi damp obstructing in middle-JIAO, gastral cavity ruffian evil of vomitting, sweet, mouth in mouth Smelly, polysialia, summer-heat and damp table disease, alliteration is uncomfortable in chest.
Mother-of-pearl: taste is salty, cold in nature.
Channel tropism: return liver, the heart channel of Hang-Shaoyin.
Function is the major functions: calming the liver, checking exuberance of yang, arresting convulsion, hemostasis.Control dizzy, tinnitus, palpitaition, insomnia, demented, frightened epilepsy, haematemesis, nosebleed Blood, metrorrhagia.
Radix Codonopsis: it is sweet in flavor, it is mild-natured.
Channel tropism: returns spleen, lung channel.
Major function: tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung.For spleen and lung weakness, shortness of breath and palpitation, anorexia and loose stool, virtual asthma cough is interior Heat is quenched one's thirst.
Levant cotton exocarp: acrid flavour, it is warm-natured
Channel tropism: stomach meridian.
Major function: warm stomach down；Preventing phlegm from forming and stopping coughing.Master is dysphagic；Stomach cold hiccup；Cough and asthma.
Herba Hyperici Monogyni: acrid flavour, it is cold in nature.
Channel tropism: return liver warp.
Effect: soothing liver-qi stagnation, clearing heat and promoting diuresis, detumescence promote lactation.
Caulis Kadsurae: bitter, it is warm-natured.
Channel tropism: return liver and kidney channel.
Function with the major functions: blood circulation promoting and enriching, menstruction regulating and pain relieving, channels sootheing and network vessel quickening.For irregular menstruation, dysmenorrhea, paralysis and numbness, rheumatism Numbness pain, deficient qi and blood.
Malt: it is sweet in flavor, it is mild-natured.
Channel tropism: returns spleen, stomach meridian.
Major function: promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling.For dyspepsia, abdominal distention, spleen eating less, cream Juice smoulders, swollen breasts, weaning women.
Mountain Cape jasmine: bitter, it is warm-natured.
Channel tropism: return heart, kidney channel.
Major function: dispelling, collateral-activating, removing blood stasis and acesodyne are used for rheumatic arthritis, enteritis, emission.
Color ultrasound stomach and intestine assistant of the present invention be oral administration, pharmaceutical dosage form can for decoction, granule, powder or Syrup, preferably granule.
The present invention passes through conscientious research to above prescription, and according to the reasonability of middle medical drugs, invention proposes this hair The preparation method of bright pharmaceutical preparation, specific steps are as follows:
1) egg shell, jujube, FRUCTUS CITRI AURANTII AMARAE, green peel, paniculate swallowwort, eupatorium, mother-of-pearl, Caulis Kadsurae, mountain are weighed respectively Cape jasmine, Herba Hyperici Monogyni, Radix Codonopsis, levant cotton exocarp, malt dry, pulverize 80~120 sieves；
2) traditional Chinese medicine powder smashed in step 1) is uniformly mixed by the weight of prescription of the present invention；
3) traditional Chinese medicine powder that will be uniformly mixed in step 2) is pelletized, and vacuum drying, whole grain is to get granule of the present invention.
The every packet weight 20g of granule of the present invention.
Usage and dosage of the present invention as color ultrasound stomach and intestine assistant:
By granule 20-40g of the present invention, it is dissolved in 100-300ml70-80 DEG C of plain boiled water, warmly takes.
Or granule 20-40g of the present invention, appropriate 70-80 DEG C of plain boiled water is added, is tuned into dense and burned, swallows, then drinks 100-300 temperature plain boiled water.
Granule of the present invention may be used as assistant use.
Purposes of the pharmaceutical preparation of the present invention in preparation treatment gastrointestinal disease drug is also used as to treat stomach The drug of ulcer uses.
Gastrointestinal disease of the present invention is gastric ulcer, acute gastritis, chronic gastritis or duodenal ulcer.
Pharmaceutical preparation of the present invention is used for, and is had the advantage that compared with prior art
(1) granule of the present invention not only can be used as assistant use, but also can be used as the drug for the treatment of gastric ulcer It uses.It is used as assistant, easy to use, good in taste, the image clearly of formation, dotted strong reecho, stomach wall level High-visible, the imagings such as gastral cavity size, form, cardia, pylorus, antrum, duodenum, lesser curvature, greater curvature are obvious, each position Lesion is high-visible.
(2) granule of the invention passes through pharmacology test and clinical test, and therapeutic effect is definite, there is that dosage is small, the course for the treatment of It is short, cure rate is high, Chinese medicine of the present invention, monarch is various, medicinal peace, does not occur toxic side effect and adverse reaction, no secondary to make With.
(3) preparation method of granule provided by the invention is simple, is suitble to industrialized production.
Specific embodiment
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.
Embodiment 1: a kind of granule and its application for color ultrasound assistant contains following raw material medicine:
10 grams of egg shell, 10 grams of jujube, 8 grams of FRUCTUS CITRI AURANTII AMARAE, 5 grams of green peel, 3 grams of paniculate swallowwort, 7 grams of eupatorium, mother-of-pearl 8 Gram, 6 grams of Caulis Kadsurae, 5 grams of mountain Cape jasmine, 4 grams of Herba Hyperici Monogyni, 13 grams of Radix Codonopsis, 6 grams of levant cotton exocarp, 7 grams of malt.
The preparation method comprises the following steps:
1) egg shell, jujube, FRUCTUS CITRI AURANTII AMARAE, green peel, paniculate swallowwort, eupatorium, mother-of-pearl, Caulis Kadsurae, mountain are weighed respectively Cape jasmine, Herba Hyperici Monogyni, Radix Codonopsis, levant cotton exocarp, malt dry, pulverize 80~120 sieves；
2) traditional Chinese medicine powder smashed in step 1) is uniformly mixed by the weight of prescription of the present invention；
3) traditional Chinese medicine powder that will be uniformly mixed in step 2) is pelletized, and vacuum drying, whole grain is to get granule of the present invention, and every bag 20g。
Embodiment 2: a kind of granule and its application for color ultrasound assistant contains following raw material medicine:
20 grams of egg shell, 18 grams of jujube, 14 grams of FRUCTUS CITRI AURANTII AMARAE, 12 grams of green peel, 8 grams of paniculate swallowwort, 14 grams of eupatorium, mother-of-pearl 14 grams, 10 grams of Caulis Kadsurae, 12 grams of mountain Cape jasmine, 11 grams of Herba Hyperici Monogyni, 17 grams of Radix Codonopsis, 13 grams of levant cotton exocarp, 13 grams of malt.
The preparation method is the same as that of Example 1.
Embodiment 3: a kind of granule and its application for color ultrasound assistant contains following raw material medicine:
15 grams of egg shell, 14 grams of jujube, 11 grams of FRUCTUS CITRI AURANTII AMARAE, 8.5 grams of green peel, 6 grams of paniculate swallowwort, 11 grams of eupatorium, pearl Female 11 grams, 8 grams of Caulis Kadsurae, 9 grams of mountain Cape jasmine, 7.5 grams of Herba Hyperici Monogyni, 15 grams of Radix Codonopsis, 10.5 grams of levant cotton exocarp, 10 grams of malt.
The preparation method is the same as that of Example 1.
Embodiment 4: a kind of granule and its application for color ultrasound assistant contains following raw material medicine:
14 grams of egg shell, 12 grams of jujube, 10 grams of FRUCTUS CITRI AURANTII AMARAE, 7.5 grams of green peel, 6 grams of paniculate swallowwort, 10 grams of eupatorium, pearl Female 10 grams, 9 grams of Yunnan chicken blood, 9 grams of mountain Cape jasmine, 6.5 grams of Herba Hyperici Monogyni, 14 grams of Radix Codonopsis, 10.5 grams of levant cotton exocarp, 9 grams of malt.
The preparation method is the same as that of Example 1.
Embodiment 5: pharmacodynamics test
5.1, animal model modeling and grouping
Kunming rat 70, between weight 180-220g, rat pre-operative anxiety 12h, normal group 5, sham-operation group 5, Model group 15, Omeprazole group 15,3 granule low dose group of embodiment (A group) 15,3 granule high dose of embodiment (B group) organizes 15, freely drinks oral rehydration salts (OregonRevisedStatutes, ORS), and ORS formula is sodium chloride 3.5 Gram, 2.5 grams of sodium bicarbonate, 1.5 grams of potassium chloride, 20 grams of powdered glucose plus pure water to 1000ml.
Rat pre-operative anxiety freely drinks oral rehydration salts 12-16h, 10% chloraldurate (3.5mL/kg weight) muscle Injecting anesthetic.With 0.5% iodophor disinfection rat abdomen skin, abdomen is opened along left rib lower edge, stomach is gently pulled out.
Tweezers (patent No.: ZL2009200151947) are prepared with the gastric ulcer of this seminar designed, designed to clamp away from pylorus Portion 3mm body of stomach region.The syringe needle for having inhaled the syringe of 0.18mL mineral oil and 0.02mL60% acetic acid in advance insertion is held under the arm and is closed In the gastral cavity in area, 0.18mL mineral oil and 0.02mL60% acetic acid are injected in the gastral cavity for holding closed zone under the arm, second is sucked out from stomach after 45s Acid, then 2mL physiological saline is injected into gastral cavity, it is sucked out after 1min, to terminate reaction.Stomach is resetted, mould is instilled into notch Plain sodium injection 0.1mL (800,000 units of Penicillin sodium being added with 4mL physiological saline, mix), successively closes abdomen.Sham-operated control group With the pure water that sterilizes instead of acetic acid.Postoperative Rat Fast freely drinks oral rehydration salts.Operation gently rubs and pays attention to sterile behaviour in art Make, to reduce adhesion.
5.2, administration mode and operation
Postoperative Rat Fast 12h, freely drinks oral rehydration salts.Water is normally fed after 12h, drinking water is pure water, daily The mouse grain of dispensing wants quantitative management.Omeprazole (AstraZeneca) presses 6.25 times of calculating rat effective doses of people's dosage, i.e., 1.04mg/kg weight stomach-filling, once a day；3 granule high and low dose group of embodiment of the present invention difference gastric infusion 4g/kg, 2g/kg, once a day, administration time are 9:00.
2d, 4d, 8d, 12d take model group and each 5 rats of test group.Rat Fast, free water 12-16h 10% chloral hydrate anesthesia afterwards opens abdomen.Abdominal aorta blood sampling, not anticoagulant, centrifugation is after 2h with spare enzyme linked immunosorbent assay (ELASA) it detects.
The detection of 5.3 inflammatory factors
The multi-function microplate reader of the ELASA detection kit, TECAN company that are produced using R&D company of the U.S. (InfiniteM200, Austria), by specification carries out the horizontal detection of blood serum IL-6, IL-8.
IL-6 dynamic change in 1 rats models of gastric ulcer serum of table
Note:
Compared with Normal group,##P < 0.01；
Compared with model control group,@P < 0.05,@@P < 0.01；
Compared with Omeprazole group,$P < 0.05,$$P < 0.01.
As it can be seen from table 1 IL-6 is significantly greater than Normal group in model group rats serum in the 2nd, 4,8,12d (P < 0.01) shows modeling success, and does not have significant difference between sham-operation group and Normal group, and excluding operation influences； In the 2nd, 4,8,12d, Omeprazole group and granule of the present invention is low, IL-6 of high dose group is significantly lower than model control group (P < 0.01 or P < 0.05), and granule high and low dose group IL-6 of the present invention is significantly lower than Omeprazole group (P < 0.05), The two all has statistical difference.
IL-8 dynamic change in 2 rats models of gastric ulcer serum of table
Group 2d (pg/ml) 4d (pg/ml) 8d (pg/ml) 12d (pg/ml)
Normal group 376.30±89.23 376.30±89.23 376.30±89.23 376.30±89.23
Sham-operation group 375.90±81.77 375.90±81.77 375.90±81.77 375.90±81.77
Model group 794.51±35.36## 733.36±23.36 732.12±24.56 695.61±36.23
B group 733.32±44.01@@$ 701.36±33.02@@$ 623.19±41.02@@$ 404.56±34.78@@$
A group 742.25±45.23@@ 712.56±33.64@@ 633.72±43.02@@ 429.01±45.23@@
Omeprazole group 745.96±36.12@@ 720.22±41.23@@ 640.37±39.36@@ 438.56±39.14@@
Note:
Compared with Normal group,##P < 0.01；
Compared with model control group,@P < 0.05,@@P < 0.01；
Compared with Omeprazole group,$P < 0.05.
From table 2 it can be seen that IL-8 is significantly greater than Normal group in model group rats serum in the 2nd, 4,8,12d (P < 0.01) shows modeling success, and does not have significant difference between sham-operation group and Normal group, and excluding operation influences； In the 2nd, 4,8,12d, Omeprazole group and granule of the present invention is low, IL-8 of high dose group is significantly lower than model control group (P < 0.01 or P < 0.05), and granule high dose group IL-8 of the present invention is significantly lower than Omeprazole group (P < 0.05), two Person all has statistical difference.It is suitble to further genralrlization application.
Embodiment 6: animal model test and experiment in vitro
The granule of embodiment 3 used in granule alternate embodiment 5 prepared by embodiment 1,2,4 repeats to implement Example 5, as a result, it has been found that granule prepared by embodiment 1,2,4 has the curative effect preferably treated.
The clinical setting of embodiment 7, Chinese medicine of the present invention treatment gastric ulcer:
7.1, case selection:
300 progress clinical observations of patients w ith peptic ulcer disease are selected, patient is randomly divided into two groups, treatment group 150, control group 150, the factors such as two groups of patient medical record, age, gender, health are almost the same, and no significant difference is comparable.
7.2, treatment method:
Treatment group patient: Chinese herbal granules prepared by the oral embodiment of the present invention 3, each 20g, 3 times a day, 7 days are one The course for the treatment of continuously takes 3 course for the treatment of；Ultrasonic examination previous hour takes orally Chinese herbal granules prepared by the embodiment of the present invention 3.
Control group patient: Omeprazole+Contents of Mosapride Citrate particle is taken by therapeutic dose, 10 days as one therapeutic course connects Continuous to take 2 course for the treatment of, ultrasonic examination previous hour takes orally barium sulfate.
7.3, curative effect judges:
Radiography is clear: radiography is clear, and stomach and intestine observation is clear, and diseased region observes clear, image clearly, and dotted strong echo is anti- It penetrates, stomach wall clear layer is as it can be seen that gastral cavity size, form, cardia, pylorus, antrum, duodenum, lesser curvature, greater curvature etc. image Obviously, each position lesion is high-visible.
Radiography is substantially clear: radiography is substantially clear, and stomach and intestine observation is substantially clear, and diseased region observes substantially clear, image Substantially clear, dotted stronger reecho, stomach wall clear layer is as it can be seen that gastral cavity size, form, cardia, pylorus, antrum, 12 The imaging such as duodenum 12, lesser curvature, greater curvature is more apparent, and each position lesion is high-visible.
It is clear that radiography is smudgy: radiography is fuzzy, and stomach and intestine observation is unclear, and diseased region observation is unclear, and echogenic dots are anti- Penetrate weaker, stomach wall level confusion, the imaging such as gastral cavity size, form, cardia, pylorus, antrum, duodenum, lesser curvature, greater curvature Unobvious, each position lesion is difficult to recognize.
7.4, visualisation
Treatment group: radiography clear 149, radiography is 1 substantially clear, radiography is smudgy clear 0,；Control group radiography is clear Clear 100, radiography is 45 substantially clear, radiography is smudgy clear 5,3 patient's reaction barium sulfate are difficult to swallow, and have vomiting Reaction, takes in barium sulfate 1 hour for 2 and flow to caecum portion, it is difficult to observe clear.
7.4, treatment results:
Cure: ulcer and inflammation disappear, and stomach secret anguish, distending pain, burns the stomach pain such as sample pain and disappears at dull pain, and stomach is dynamic Power is restored, and metabolism restores normal.
Improve: ulcer disappears or ulcer area reduces 50% or more, and surrounding tissue inflammatory reaction mitigates or subsides, stomach Discomfort mitigates, and WeiDongLi Capsule is restored.
Invalid: ulcer area is unchanged or diminution is less than 50% or symptom is unchanged.
By treating wherein treatment group: 140 are cured, is improved 8, invalid 2, cure rate 93.3%, total effective rate It is 98.6%；Control group: curing 88, improves 37, and invalid 25, cure rate 58.7%, total effective rate 83.3%.With Above the results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group.
Scope follow-up is carried out when to ulcer healing patient 12 months after the course for the treatment of, counts ulcer recurrence rate.Wherein control 138 healing patients for the treatment of group have 130 people to obtain follow-up, and 47 people of control group healing person obtains follow-up, two groups of gastric ulcer recurrence rate ratios Relatively it is shown in Table 3.The experimental results showed that, the traditional chinese medicine composition of the invention has cure rate height, no in the treatment for gastric ulcer above Advantage easy to recur, every statistical data is all due to western medicine control group.
The follow-up individual treatment effect of 3 treatment group of table and control group is as follows
Group Follow-up individual Relapse individual Recurrence rate
Treatment group 140 1 0.71%
Control group 85 22 25.88%
7.6, typical case
Case 1: Zou, male 40 years old, Kunming people from Wuhua District, the person in charge of the project, the inspection of 2014 Nian Lai our hospital, nearest one section of main suit Time stomach indigestion, ate digestion-promoting stomachic etc., and effect is not significant, and has a stomachache often, the radiography of oral embodiment 3 when inspection Agent, no vomiting situation occur, and radiography is clear, and stomach is in fishhook-type, on an empty stomach without stomach pool stream；Antrum pleat irregular arrangement increases Slightly.Stomach wall wriggling is poor, and duodenal bulb form is normal, and tentative diagnosis is acute gastritis, in checking process, patient's oral account Stomachache has mitigation, and without sense of discomfort, satiety is eliminated.
Case 2: Zheng, male 42 years old, people from Xuzhou, the people's teacher, patient's chronic dietary is irregular, 2015 Nian Lai our hospital It checks, patient main suit's stomach meridian sour regurgitation, and have burning sensation, when inspection has drunk 200ml38 degree white wine, takes orally the contrast agent of embodiment 4 Observation, stomach image clearly, dotted strong reecho, stomach wall clear layer is as it can be seen that gastral cavity size, form, cardia, pylorus, stomach The imagings such as sinus, duodenum, lesser curvature, greater curvature are obvious, and each position lesion is high-visible, tumour phenomenon excluded, after taking Symptom of having a stomachache mitigates, and the clear result of radiography: there is rotten to the corn face in the small crook of body of stomach, is diagnosed as chronic gastritis and gastrorrhagia.Taking orally this 4 contrast agent of embodiment of invention, in checking process, patient does not vomit phenomenon, and oral account burning sensation reduces, and without sense of discomfort.
Case 3: Lyu, male 42 years old, Lianyungang of Jiangsu people, pharmaceutical factory worker, the frequent night shift of patient, the regular pain of stomach, Canel barium meal contrast examination is done at the beginning, it is difficult to be swallowed, and 1 hour barium meal arrived ileocecus, fail smooth radiography.Take of the invention make The contrast agent of shadow agent embodiment 1 is checked that no stomachache, vomiting situation occur, and radiography is clear, and stomach is in fishhook-type, and cardia is no different Often discovery, stomach tension is medium, is in osculant, sees a small amount of retention liquid in gastral cavity, antrum portion mucosal pattern thickening, stomach wall is still soft, compacted Dynamic normal, duodenal bulb form is normal.In oral 4 contrast agent of the embodiment of the present invention, checking process, patient does not vomit Phenomenon is spat, oral account burning sensation reduces, and without sense of discomfort.

Claims (8)

1. a kind of pharmaceutical preparation for stomach and intestine color ultrasound assistant, it is characterised in that: the pharmaceutical preparation includes following weight Part Chinese medicine: 10-20 portions of egg shell, 8-14 parts of FRUCTUS CITRI AURANTII AMARAE, 5-12 parts of green peel, 3-8 parts of paniculate swallowwort, is worn at 10-18 parts of jujube 7-14 parts blue, 8-14 parts of mother-of-pearl, 6-10 parts of Caulis Kadsurae, 5-12 parts of mountain Cape jasmine, 4-11 parts of Herba Hyperici Monogyni, 13-17 parts of Radix Codonopsis, 6-13 parts of levant cotton exocarp, 7-13 parts of malt.
2. pharmaceutical preparation according to claim 1, which is characterized in that the pharmaceutical preparation includes following parts by weight Chinese medicine Material: 15 parts of egg shell, 14 parts of jujube, 11 parts of FRUCTUS CITRI AURANTII AMARAE, 8.5 parts of green peel, 6 parts of paniculate swallowwort, 11 parts of eupatorium, mother-of-pearl 11 Part, 8 parts of Caulis Kadsurae, 9 parts of mountain Cape jasmine, 7.5 parts of Herba Hyperici Monogyni, 15 parts of Radix Codonopsis, 10.5 parts of levant cotton exocarp, 10 parts of malt.
3. pharmaceutical preparation according to claim 1, which is characterized in that the pharmaceutical preparation includes following parts by weight Chinese medicine Material: 14 parts of egg shell, 12 parts of jujube, 10 parts of FRUCTUS CITRI AURANTII AMARAE, 7.5 parts of green peel, 6 parts of paniculate swallowwort, 10 parts of eupatorium, mother-of-pearl 10 Part, 98 parts of Yunnan chicken blood, 9 parts of mountain Cape jasmine, 6.5 parts of Herba Hyperici Monogyni, 14 parts of Radix Codonopsis, 10.5 parts of levant cotton exocarp, 9 parts of malt.
4. a kind of prepare the described in any item pharmaceutical preparations of claim 1-3, which is characterized in that specific step are as follows:
1) egg shell is weighed respectively, jujube, FRUCTUS CITRI AURANTII AMARAE, green peel, paniculate swallowwort, eupatorium, mother-of-pearl, Caulis Kadsurae, mountain Cape jasmine, is passed through Leaf Hypericum Chinense, Radix Codonopsis, levant cotton exocarp, malt dry, pulverize 80~120 sieves；
2) traditional Chinese medicine powder smashed in step 1) is uniformly mixed by the weight of prescription of the present invention；
3) traditional Chinese medicine powder that will be uniformly mixed in step 2) is pelletized, and vacuum drying, whole grain is to get granule of the present invention.
5. pharmaceutical preparation according to claim 4, which is characterized in that the every packet weight 20g of the granule of step 3).
6. pharmaceutical preparation according to claim 1, it is characterised in that: the pharmaceutical preparation helps shadow preparing stomach and intestine color ultrasound Application in agent.
7. pharmaceutical preparation according to claim 1, it is characterised in that: the pharmaceutical preparation treats gastrointestinal disease in preparation Application in drug.
8. pharmaceutical preparation according to claim 7, it is characterised in that: the gastrointestinal disease be gastric ulcer, acute gastritis, Chronic gastritis or duodenal ulcer.
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CN101422622A (en) * 2008-12-09 2009-05-06 秦峰 B-ultrasonic traditional Chinese medicine imaging assistant and preparation method thereof
CN104258430A (en) * 2014-09-16 2015-01-07 济南伟传信息技术有限公司 Traditional Chinese medicine gastrointestinal developing aid for B-ultrasound
CN104258431A (en) * 2014-10-23 2015-01-07 庄成龙 Traditional Chinese medicine B-ultrasonic shadow aid and application thereof
CN104984369A (en) * 2015-07-23 2015-10-21 王桂霞 Traditional Chinese medicine composition for preparing color Doppler ultrasound contrast agent, applications and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN101422622A (en) * 2008-12-09 2009-05-06 秦峰 B-ultrasonic traditional Chinese medicine imaging assistant and preparation method thereof
CN104258430A (en) * 2014-09-16 2015-01-07 济南伟传信息技术有限公司 Traditional Chinese medicine gastrointestinal developing aid for B-ultrasound
CN104258431A (en) * 2014-10-23 2015-01-07 庄成龙 Traditional Chinese medicine B-ultrasonic shadow aid and application thereof
CN104984369A (en) * 2015-07-23 2015-10-21 王桂霞 Traditional Chinese medicine composition for preparing color Doppler ultrasound contrast agent, applications and preparation method thereof

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