CN104984369A - Traditional Chinese medicine composition for preparing color Doppler ultrasound contrast agent, applications and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preparing color Doppler ultrasound contrast agent, applications and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for preparing a color Doppler ultrasound contrast agent, applications and a preparation method thereof. The traditional Chinese medicine composition is composed of the following raw materials: turtle shell, radix astragali, bletilla striata, cuttlebone, dried alum, egg shell, radix codonopsis, dried orange peel, semen cuscutae, and talcum powder. The provided traditional Chinese medicine composition can be used as a contrast agent used in the digestive tracts, and also has a pharmacologic effect, so the composition can be used to treat diseases such as gastrointestinal ulcer, gastrointestinal bleeding, and the like in clinic.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of pharmaceutical composition and application thereof and preparation method, be specifically related to the medicine of a kind of color ultrasound contrast agent and treatment gastric ulcer.
Background technology
Because human intestines and stomach belongs to hollow organ, generally, color ultrasound is utilized can not well to show coat of the stomach level.The form that the use of contrast agent can make gastral cavity fill well to show stomach, gastral cavity size, coat of the stomach level, emptying time and gastropathy position, can also show the pathological changes situation of small intestinal and colon simultaneously.
Contrast agent conventional is at present mainly barium sulfate and Operand, and the verified existing contrast agent consumption of right existing research is the independent hazard factor causing contrast agent nephropathy.In addition contrast agent can also cause that patient Herba Urticae Cannabinae is examined, angioedema, laryngeal edema, bronchospasm, the serious idiosyncratic reaction such as blood pressure drops and sudden death.This kind of contrast agent adds extra burden to gastrointestinal tract simultaneously, adds the misery of patient.
For B ultrasonic gastrointestinal contrast agent, prior art describes the contrast agent be mixed with by the 100 order fine powders of Endoconcha Sepiae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20%, to gastrointestinal disease, there is convergence, antacid effect, but weak point is patient take contrast agent after to produce strong echo luminous point not enough, reflecting effect is not good, and the display of coat of the stomach level is unintelligible; After patient takes this contrast agent, gastric acid strong reaction, has pain and sense of discomfort, is unfavorable for the ultrasonic contrast of gastrointestinal, can not applies this contrast agent to gastrorrhagia patient.
Chinese invention patent application number: 201110003326.6 disclose a kind of B ultrasonic use Chinese medicine contrast agent, the ratio of weight and number of various crude drug is: the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Rhizoma Curcumae Longae, Pericarpium Citri Reticulatae 10 ~ 20 parts, Cortex Magnoliae Officinalis 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Endoconcha Sepiae 10 ~ 20 parts, Concha Ostreae (calcined) 10 ~ 20 parts, Rhizoma Dioscoreae 10 ~ 20 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10 ~ 20 parts, Semen Myristicae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts.Said composition flavour of a drug are relatively various, and formula is complicated, preparation relative difficulty.
Chinese invention patent application 201310480244.X discloses a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic and preparation method thereof, and Chinese medicine gastrointestinal contrast agent comprises following raw medicinal material: Ovum Gallus domesticus crusta, starfish, Concha Meretricis Seu Cyclinae, Fructus Elaeagni, Herba Agrimoniae, Radix Glycyrrhizae, Os Draconis (calcined), Herba Hyperici perforati, Herba Lythri Salicariae, Fructus Schisandrae Sphenantherae, Radix Et Rhizoma Rhei, Radix rubi elliptici, Cornu Cervi Degelatinatum, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), Flos lupuli (Flos Humuli Lupuli), Fructus Amomi subulati, Fructus clausenae lansii, Radix Et Rhizoma Nardostachyos, Pericarpium Arecae, Herba Pugionii Cornuti and Rhizoma Curcumae.Equally, said composition flavour of a drug are relatively various, and formula is complicated, preparation relative difficulty.
Chinese invention patent application numbers 201410107613.5 discloses a kind of gastrointestinal contrast agent, be made up of the component of following parts by weight: barium sulfate 50-60 part, Chinese medicine extract 40-50 part, wherein, Chinese medicine extract is made up of the medical material of following parts by weight: Radix Glehniae 10-15 part, Carapax Trionycis 10-20 part, Bulbus Lilii 10-20 part, Crinis Carbonisatus 5-10 part, Caulis Bambusae In Taenia 3-9 part, Rhizoma Alpiniae Officinarum 3-6 part, Bulbus Allii Macrostemonis 5-10 part, Calyx Kaki 3-9 part, Fructus Crataegi 10-20 part, Massa Medicata Fermentata 8-10 part, Radix Saposhnikoviae 5-10 part, Ramulus Cinnamomi 5-10 part, Fructus Mori 10-30 part.Contrast agent of the present invention, side effect is low, and except having radiography function, also can play stomach, liver etc. and take good care of or therapeutical effect, function is no longer single, and result of use is better, also can be suitable for gastrorrhagia patient.This compositions, can not as medicine life-time service still containing barium sulfate.
Summary of the invention
The present invention is specifically related to a kind of pharmaceutical composition and application thereof and preparation method, and Chinese medicine composition of the present invention both can use as color ultrasound contrast agent, also can as the drug use for the treatment of gastric ulcer.
An object of the present invention is to provide a kind of pharmaceutical composition, it is characterized in that being made up of following raw material: Carapax et Plastrum Testudinis, the Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, dried Alumen, Ovum crusta Gallus domesticus, Radix Codonopsis, Pericarpium Citri Reticulatae, Semen Cuscutae, Pulvis Talci.
As preferably, pharmaceutical composition of the present invention is made up of the raw material of following parts by weight:
Carapax et Plastrum Testudinis 12-30, Radix Astragali 8-24, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-20, Endoconcha Sepiae 12-30, dried Alumen 2-12, Ovum crusta Gallus domesticus 4-12, Radix Codonopsis 8-24, Pericarpium Citri Reticulatae 4-12, Semen Cuscutae 8-24, Pulvis Talci 4-12.
As one of optimal technical scheme, pharmaceutical composition of the present invention is made up of the raw material of following parts by weight:
Carapax et Plastrum Testudinis 30, the Radix Astragali 24, the Pseudobulbus Bletillae (Rhizoma Bletillae) 16, Endoconcha Sepiae 24, dried Alumen 6, Ovum crusta Gallus domesticus 8, Radix Codonopsis 16, Pericarpium Citri Reticulatae 8, Semen Cuscutae 20, Pulvis Talci 8.
As optimal technical scheme two, pharmaceutical composition of the present invention is made up of the raw material of following parts by weight:
Carapax et Plastrum Testudinis 24, the Radix Astragali 20, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20, Endoconcha Sepiae 20, dried Alumen 4, Ovum crusta Gallus domesticus 8, Radix Codonopsis 8, Pericarpium Citri Reticulatae 6, Semen Cuscutae 12, Pulvis Talci 8.
As optimal technical scheme three, pharmaceutical composition of the present invention is made up of the raw material of following parts by weight:
Carapax et Plastrum Testudinis 12, the Radix Astragali 12, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Endoconcha Sepiae 12, dried Alumen 2, Ovum crusta Gallus domesticus 4, Radix Codonopsis 8, Pericarpium Citri Reticulatae 6, Semen Cuscutae 8, Pulvis Talci 4.
In Chinese medicine composition of the present invention, the property of medicine of each medicine is as follows:
Carapax et Plastrum Testudinis: be carapace and the sternite of Testudinidae animal Testudinis.Nature and flavor are salty, sweet, are slightly cold.Return liver, kidney, heart channel.Nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.
The Radix Astragali: nature and flavor are sweet, temperature.Gui Jing returns lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor are bitter, sweet, puckery, are slightly cold.Gui Jing: return lung, liver, stomach warp.Function cures mainly: astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Endoconcha Sepiae: nature and flavor are salty, puckery, temperature.Gui Jing: return spleen, kidney channel.Function cures mainly: astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.
Dried Alumen: have another name called calcined Alumen.Get and pick clean Alumen, put heating in marmite and dissolve and be calcined to dried-up, to obtain final product.Function cures mainly: expectorant, dampness, antidiarrheal, hemostasis, taste-blindness rate, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite etc.
Ovum crusta Gallus domesticus: nature and flavor are light is flat.Function cures mainly convergence antacid, replenishes the calcium.For chronic gastritis, gastric and duodenal ulcers, rickets.
Radix Codonopsis: nature and flavor are sweet is flat.Gui Jing returns spleen, lung meridian.Function cures mainly invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Gui Jing returns lung, spleen channel.Function cures mainly regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Semen Cuscutae: nature and flavor are sweet, temperature.Gui Jing returns liver,kidney,spleen warp.Function cures mainly nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Pulvis Talci: nature and flavor are sweet, light, cold.Gui Jing returns bladder, lung, stomach warp.Function cures mainly inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.
Two of object of the present invention is to provide the purposes of a kind of aforementioned pharmaceutical compositions as color ultrasound contrast agent aspect.
Three of object of the present invention is to provide the purposes of a kind of aforementioned pharmaceutical compositions as aspect such as medicine such as preparation treatment gastric ulcer, gastrointestinal hemorrhage etc.
The medicine of pharmaceutical composition of the present invention conveniently can be prepared into conventional formulation by formulation method.Such as: granule, decoction, powder, syrup etc.
Four of object of the present invention is to provide the preparation method of a kind of aforementioned pharmaceutical compositions powder and granule, comprises following steps:
1) take Carapax et Plastrum Testudinis, the Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, dried Alumen, Ovum crusta Gallus domesticus, Radix Codonopsis, Pericarpium Citri Reticulatae, Semen Cuscutae, Pulvis Talci respectively by weight, dry, pulverize 80 ~ 200 sieves;
2) by step 1) in pulverize after Chinese medicine powder mix homogeneously;
3) by step 2) in the Chinese medicine powder of mix homogeneously, vacuum drying, obtains powder of the present invention.
4) by step 2) in the Chinese medicine powder of mix homogeneously, add preparation adjuvant, granulate, vacuum drying, granulate, obtains granule of the present invention.
Preferably, step 3) and step 4) vacuum drying temperature is 50-70 DEG C.In experimentation, inventor finds when baking temperature is more than 70 DEG C, and during the drug use as treatment gastric ulcer of the pharmaceutical composition of preparation, effect variation, even without therapeutic effect, therefore baking temperature should not be greater than 70 DEG C.
Five of object of the present invention is to provide a kind of using method of aforementioned pharmaceutical compositions.
The present invention is as the usage and dosage of color ultrasound gastrointestinal contrast agent:
Get powder 20-40g of the present invention, be dissolved in 100-300 milliliter 60-70 DEG C of boiled water, stir decoction being taken warmly.
Or powder 15 ~ 30g of the present invention is added appropriate 60-70 DEG C boiled water, and furnishing is dense and burned, swallows, then drink 100-300 temperature boiled water.
The present invention treats usage and dosage when gastric ulcer, gastrointestinal hemorrhage:
Getting granule of the present invention, each 5-10g, every day 3 times, 7 days is a course for the treatment of, takes 2-3 the course for the treatment of continuously.
The present invention compared with prior art has the following advantages:
1. pharmaceutical composition of the present invention had both met the requirement of digestive tract contrast agent, had pharmacological action again, except digestive tract contrast agent, also can be used for the treatment of the disease such as gastroenteritic ulcer, gastrointestinal hemorrhage clinically except for doing.
2. pharmaceutical composition of the present invention is through the anxious poison of animal and long term toxicity test checking, has no side effect, use safety.
3. medicine of the present invention uses as contrast agent, can antacid pain relieving, easy to use, cost is low, clear picture, the strong reecho of point-like, coat of the stomach clear layer is visible, and the video pictures such as gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature are obvious, and each position focus is high-visible.As treatment gastric ulcer, gastrointestinal haemorrhagia drug use time, there is the advantage that consumption is little, short treating period, cure rate are high.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, and for a person skilled in the art, without departing from the inventive concept of the premise, some changes or the replacement made, all should be considered as belonging to protection scope of the present invention.
Embodiment 1
Medicine of the present invention is to the acute toxicity test of mice:
Get 20 ± 2g mice 12, male and female half and half, with medicine of the present invention disposable gastric infusion in the morning 8 time, administration capacity is 0.2g/10g, Continuous Observation 14 days, record mouse toxicity day by day reacts and death toll, experimental result shows, after mice perfusion, first occurs hypokinesia, recover normal very soon, without animal dead phenomenon.To mouse stomach administration 200g/kg, calculate by kg body weight, 467 times of every consumption per day that is equivalent to be grown up, press the conversion of system number, be equivalent to 70kg and be grown up more than 50 times of every consumption per day, then animal death in one week, shows that its LD50 must be greater than 200g/kg.The maximum tolerated dose of its result display mice administration is at more than 200g/kg, and oral administration is very safe.Prove the oral safety of the present invention.
Embodiment 2
Medicine of the present invention is to the long term toxicity test of rat:
Get SD rat 24, male and female half and half, be divided into three groups at random, high dose group of the present invention is equivalent to the medicine gavage of 50 times of adult's quantity, and low dose group of the present invention is equivalent to the medicine gavage of 20 times of adult's quantity; Blank group, gives equivalent distilled water.According to the pertinent regulations in " new Chinese medicine preclinical study guide ", gavage is carried out to rat, weekly gastric infusion 7 days, continuous 4 weeks with maximum concentration, maximum gavage volume, after raising with condition, the each group of equal well-grown of rat, freely, hair color is glossy in activity, diet and urine are all normal, body weight natural increase, does not find obvious toxic reaction, does not also occur animal dead.Through checking each group of rat blood routine, blood parameters all in normal range, important organ histopathologic examination does not find obvious toxic lesion.
Embodiment 3
The preparation of powder of the present invention:
Take Carapax et Plastrum Testudinis 12kg, Radix Astragali 12kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 12kg, Endoconcha Sepiae 12kg, dried Alumen 2kg, Ovum crusta Gallus domesticus 4kg, Radix Codonopsis 8kg, Pericarpium Citri Reticulatae 6kg, Semen Cuscutae 8kg, Pulvis Talci 4kg respectively, dry, pulverize 150 sieves; Mix homogeneously; Add correctives, 60 DEG C of vacuum dryings, obtain powder.
Embodiment 4
The preparation of powder of the present invention:
Take Carapax et Plastrum Testudinis Carapax et Plastrum Testudinis 24kg, Radix Astragali 20kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 20kg, Endoconcha Sepiae 20kg, dried Alumen 4kg, Ovum crusta Gallus domesticus 8kg, Radix Codonopsis 8kg, Pericarpium Citri Reticulatae 6kg, Semen Cuscutae 12kg, Pulvis Talci 8kg respectively, dry, pulverize 200 sieves; Mix homogeneously; Add correctives, 68 DEG C of vacuum dryings, obtain powder.
Embodiment 5
The preparation of powder of the present invention:
Take Carapax et Plastrum Testudinis Carapax et Plastrum Testudinis 30kg, Radix Astragali 24kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 16kg, Endoconcha Sepiae 24kg, dried Alumen 6kg, Ovum crusta Gallus domesticus 8kg, Radix Codonopsis 16kg, Pericarpium Citri Reticulatae 8kg, Semen Cuscutae 20kg, Pulvis Talci 8kg respectively, dry, pulverize 150 sieves; Mix homogeneously; Add correctives, 60 DEG C of vacuum dryings, obtain powder.
Embodiment 6
The preparation of granule of the present invention:
Take Carapax et Plastrum Testudinis 12kg, Radix Astragali 12kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 12kg, Endoconcha Sepiae 12kg, dried Alumen 2kg, Ovum crusta Gallus domesticus 4kg, Radix Codonopsis 8kg, Pericarpium Citri Reticulatae 6kg, Semen Cuscutae 8kg, Pulvis Talci 4kg respectively, dry, pulverize 150 sieves; Mix homogeneously; Add correctives, alcohol granulation, 70 DEG C of vacuum dryings, granulate, obtains granule.
Embodiment 7
The preparation of granule of the present invention:
Take 24kg, Radix Astragali 20kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 20kg, Endoconcha Sepiae 20kg, dried Alumen 4kg, Ovum crusta Gallus domesticus 8kg, Radix Codonopsis 8kg, Pericarpium Citri Reticulatae 6kg, Semen Cuscutae 12kg, Pulvis Talci 8kg respectively, dry, pulverize 150 sieves; Mix homogeneously; Add correctives, alcohol granulation, 70 DEG C of vacuum dryings, granulate, obtains granule.
Embodiment 8
The preparation of granule of the present invention:
Take Carapax et Plastrum Testudinis Carapax et Plastrum Testudinis 30kg, Radix Astragali 24kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 16kg, Endoconcha Sepiae 24kg, dried Alumen 6kg, Ovum crusta Gallus domesticus 8kg, Radix Codonopsis 16kg, Pericarpium Citri Reticulatae 8kg, Semen Cuscutae 20kg, Pulvis Talci 8kg respectively, dry, pulverize 150 sieves; Mix homogeneously; Add correctives, alcohol granulation, 70 DEG C of vacuum dryings, granulate, obtains granule.
Embodiment 9
Pharmaceutical composition of the present invention is as the infective use of contrast agent:
Get the agent of embodiment of the present invention 1-3 powder, take through 166 routine patient clinicals, use safety, no pain, without sense of discomfort and anaphylaxis, the review time is short, and imaging efficiency is high, image stabilization, excellent visualization ratio 95.0%, general visualization ratio 5.0%.Can to clarify a diagnosis the various gastrointestinal disease such as superficial gastritis, gastric ulcer, hypertrophic gastritis, prolapse of gastric mucosa, gastric cancer, pyloric part tumor, gastroptosis and duodenitis.Compared with gastroscopy, superficial gastritis diagnostic accordance rate more than 93.0%, gastric cancer coincidence rate more than 89%.
Embodiment 10
The clinical setting of medicine composite for curing gastric ulcer of the present invention:
1 case selection:
Select medical patients w ith peptic ulcer disease 160 example in certain the People's Hospital of city to carry out clinical observation, patient is divided into two groups at random, treatment group 100 example, and matched group 60 example, two groups of patient medical record are basically identical, without significant difference, have comparability.
2. Therapeutic Method:
Treatment group person suffers from the Chinese medicine granules of the oral embodiment of the present invention 5 preparation, each 5g, and every day 3 times 7 days is a course for the treatment of, takes 3 courses for the treatment of continuously;
Matched group takes omeprazole+amoxicillin+clarithromycin, within 10 days, is a course for the treatment of, takes 2 courses for the treatment of continuously.
3 Outcome measure:
Cure: stomach dull pain, dull pain, distending pain, burn the stomach pain such as sample pain and disappear, gastric motility recovers, and metabolism recovers normally.
Take a turn for the better: stomach discomfort alleviates, and gastric motility recovers to some extent.
Invalid: symptom is unchanged.
4 therapeutic outcomes:
Treatment group: cure 82 examples, take a turn for the better 16 examples, and invalid 2 examples, cure rate is 82.0%, and total effective rate is 98.0%.
Matched group: cure 42 examples, take a turn for the better 9 examples, and no effect 9, cure rate is 70.0%, and total effective rate is 85.0%.
The display of above result, the cure rate for the treatment of group and total effective rate are apparently higher than the triple therapy of matched group.
Visible pharmaceutical composition of the present invention both can use as contrast agent, as the drug use for the treatment of gastric ulcer, and can have the advantage that consumption is little, short treating period, cure rate are high again, be suitable for clinical expansion and use.
Claims (10)
1. prepare a Chinese medicine composition for color ultrasound contrast agent, it is characterized in that, it is characterized in that being made up of following raw material: Carapax et Plastrum Testudinis, the Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, dried Alumen, Ovum crusta Gallus domesticus, Radix Codonopsis, Pericarpium Citri Reticulatae, Semen Cuscutae, Pulvis Talci.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Carapax et Plastrum Testudinis 12-30, Radix Astragali 8-24, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-20, Endoconcha Sepiae 12-30, dried Alumen 2-12, Ovum crusta Gallus domesticus 4-12, Radix Codonopsis 8-24, Pericarpium Citri Reticulatae 4-12, Semen Cuscutae 8-24, Pulvis Talci 4-12.
3. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Carapax et Plastrum Testudinis 30, the Radix Astragali 24, the Pseudobulbus Bletillae (Rhizoma Bletillae) 16, Endoconcha Sepiae 24, dried Alumen 6, Ovum crusta Gallus domesticus 8, Radix Codonopsis 16, Pericarpium Citri Reticulatae 8, Semen Cuscutae 20, Pulvis Talci 8.
4. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Carapax et Plastrum Testudinis 24, the Radix Astragali 20, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20, Endoconcha Sepiae 20, dried Alumen 4, Ovum crusta Gallus domesticus 8, Radix Codonopsis 8, Pericarpium Citri Reticulatae 6, Semen Cuscutae 12, Pulvis Talci 8.
5. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Carapax et Plastrum Testudinis 12, the Radix Astragali 12, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Endoconcha Sepiae 12, dried Alumen 2, Ovum crusta Gallus domesticus 4, Radix Codonopsis 8, Pericarpium Citri Reticulatae 6, Semen Cuscutae 8, Pulvis Talci 4.
6. the pharmaceutical composition as described in as arbitrary in claim 1-5 is as the purposes of color ultrasound contrast agent aspect.
7. the purposes of the pharmaceutical composition as described in as arbitrary in claim 1-5 in medicine such as preparation treatment gastric ulcer, gastrointestinal hemorrhage etc.
8. the pharmaceutical dosage form of the pharmaceutical composition as described in as arbitrary in claim 1-7 is granule, decoction, powder, syrup etc.
9. pharmaceutical composition as claimed in claim 8, is characterized in that described powder and the preparation method of granule, comprises following steps:
1) take Carapax et Plastrum Testudinis, the Radix Astragali, the Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae, dried Alumen, Ovum crusta Gallus domesticus, Radix Codonopsis, Pericarpium Citri Reticulatae, Semen Cuscutae, Pulvis Talci respectively by weight, dry, pulverize 80 ~ 200 sieves;
2) by step 1) in pulverize after Chinese medicine powder mix homogeneously;
3) by step 2) in the Chinese medicine powder of mix homogeneously, vacuum drying, obtains powder;
4) by step 2) in the Chinese medicine powder of mix homogeneously, add preparation adjuvant, granulate, vacuum drying, granulate, obtains granule;
Preferably, described step 3) and step 4) vacuum drying temperature is 50-70 DEG C.
10. the pharmaceutical composition as described in as arbitrary in claim 1-9, it is characterized in that, using method is as follows:
Usage and dosage as color ultrasound gastrointestinal contrast agent:
Get powder 20-40g of the present invention, be dissolved in 100-300 milliliter 60-70 DEG C of boiled water, stir decoction being taken warmly;
Or powder 15 ~ 30g of the present invention is added appropriate 60-70 DEG C boiled water, and furnishing is dense and burned, swallows, then drink 100-300 temperature boiled water;
Usage and dosage as when treatment gastric ulcer, gastrointestinal hemorrhage drug use:
Getting granule of the present invention, each 5-10g, every day 3 times, 7 days is a course for the treatment of, takes 2-3 the course for the treatment of continuously.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105770920A (en) * | 2016-04-07 | 2016-07-20 | 邱发龙 | Medicinal preparation for stomach-intestine color-Doppler-ultrasound image assisting agent and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068707A (en) * | 2011-01-10 | 2011-05-25 | 张洪英 | Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof |
| CN104258431A (en) * | 2014-10-23 | 2015-01-07 | 庄成龙 | Traditional Chinese medicine B-ultrasonic shadow aid and application thereof |
| CN104353089A (en) * | 2014-10-14 | 2015-02-18 | 刘树芹 | Color Doppler ultrasound contrast medium comprising traditional Chinese medicines as well as application and preparation method of medium |
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2015
- 2015-07-23 CN CN201510441921.6A patent/CN104984369A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068707A (en) * | 2011-01-10 | 2011-05-25 | 张洪英 | Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof |
| CN104353089A (en) * | 2014-10-14 | 2015-02-18 | 刘树芹 | Color Doppler ultrasound contrast medium comprising traditional Chinese medicines as well as application and preparation method of medium |
| CN104258431A (en) * | 2014-10-23 | 2015-01-07 | 庄成龙 | Traditional Chinese medicine B-ultrasonic shadow aid and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770920A (en) * | 2016-04-07 | 2016-07-20 | 邱发龙 | Medicinal preparation for stomach-intestine color-Doppler-ultrasound image assisting agent and application thereof |
| CN105770920B (en) * | 2016-04-07 | 2019-01-01 | 青岛市中心医院 | A kind of pharmaceutical preparation and its application for stomach and intestine color ultrasound assistant |
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