CN104353089A - Color Doppler ultrasound contrast medium comprising traditional Chinese medicines as well as application and preparation method of medium - Google Patents
Color Doppler ultrasound contrast medium comprising traditional Chinese medicines as well as application and preparation method of medium Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a color Doppler ultrasound contrast medium comprising traditional Chinese medicine components as well as an application and a preparation method of the medium. The color Doppler ultrasound contrast medium comprising the traditional Chinese medicine components is prepared from raw materials in parts by weight as follows: 8-20 parts of pearl, 8-20 parts of nutmeg, 8-20 parts of spine date seed, 6-20 parts of Chinese magnoliavine fruit, 6-12 parts of maticated leaven, 2-10 parts of long pepper and 1-8 parts of egg shell. The contrast medium has the benefits that the medicinal materials are free of toxic and side effects as well as anaphylactic reactions, and the contrast medium can be used as a contrast medium as well as a medicine for treating gastric ulcers; the contrast medium can relieve gastric acid and stomachache and is convenient to use, low in cost and clear in image when used as the contrast medium; the contrast medium has the advantages of small usage amount, short treatment course and high cure rate when used as the medicine for treating the gastric ulcers.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of color ultrasound contrast agent containing Chinese medicinal ingredients and application thereof and preparation method.
Background technology
Ultrasonic image diagnosis is one of important diagnostic method in medical science.Ultrasound wave has three to act on greatly to material: one is mechanism, because ultrasonic energy is huge, often makes material particle do altofrequency mechanical vibration, thus produce smash, condense, agitation effects.Two is warm-heat effect, and ul-trasonic irradiation is when material, and its energy is absorbed by material, thus makes mass temperature raise phenomenon.Three is cavitations, when ul-trasonic irradiation is on liquid, become sparse in the region (if any microscopic bubble etc.) of liquid internal stress weakness due to acoustic pressure great variety, at this moment around under the effect of fluid molecule pulling force, form a little cavity, be cavitation.
Because human intestines and stomach belongs to hollow organ, generally, color ultrasound is utilized can not well to show coat of the stomach level.The form that the use of contrast agent can make gastral cavity fill well to show stomach, gastral cavity size, coat of the stomach level, emptying time and gastropathy position, can also show the pathological changes situation of small intestinal and colon simultaneously.
Contrast agent conventional is at present mainly barium sulfate and Operand, and the verified existing contrast agent consumption of right existing research is the independent hazard factor causing contrast agent nephropathy.In addition contrast agent can also cause that patient Herba Urticae Cannabinae is examined, angioedema, laryngeal edema, bronchospasm, the serious idiosyncratic reaction such as blood pressure drops and sudden death.This kind of contrast agent adds extra burden to gastrointestinal tract simultaneously, adds the misery of patient.
Summary of the invention
The object of the invention is to overcome the defect that prior art exists, provide a kind of safe without toxic side effect, video picture rate is high, Chinese medicine color ultrasound gastrointestinal contrast agent easy to use and application thereof and preparation method.
For solving the problems of the technologies described above, one of the object of the invention is to provide a kind of color ultrasound gastrointestinal contrast agent be prepared from by Margarita, Semen Myristicae, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Massa Medicata Fermentata, Fructus Piperis Longi, Ovum crusta Gallus domesticus, particularly, it is made up of the raw material of following ratio of weight and number:
Margarita 8-20 part Semen Myristicae 8-20 part Semen Ziziphi Spinosae 8-20 part Fructus Schisandrae Chinensis 6-20 part
Massa Medicata Fermentata 6-12 part Fructus Piperis Longi 2-10 part Ovum crusta Gallus domesticus 1-8 part
Color ultrasound gastrointestinal contrast agent of the present invention, can preferably, be made up of the raw material of following ratio of weight and number:
Margarita 18 parts of Semen Myristicaes 16 parts of Semen Ziziphi Spinosaes 16 parts of Fructus Schisandrae Chinensis 12 parts
Massa Medicata Fermentata 12 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 2 parts
Color ultrasound gastrointestinal contrast agent of the present invention, can also preferably, be made up of the raw material of following ratio of weight and number:
Margarita 14 parts of Semen Myristicaes 8 parts of Semen Ziziphi Spinosaes 16 parts of Fructus Schisandrae Chinensis 8 parts
Massa Medicata Fermentata 8 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 4 parts
Color ultrasound gastrointestinal contrast agent of the present invention, can preferably, be made up of the raw material of following ratio of weight and number again:
Margarita 8 parts of Semen Myristicaes 12 parts of Semen Ziziphi Spinosaes 8 parts of Fructus Schisandrae Chinensis 6 parts
Massa Medicata Fermentata 6 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 6 parts
In side of the present invention: Margarita powder: sweet, salty, cold.GUIXIN, Liver Channel.To calm the nerves arresting convulsion, improving eyesight removing nebula, removing toxic substances and promoting granulation.For insomnia of palpitating with fear, infantile convulsion epilepsy, the raw nebula of order, skin infection is not held back.Semen Myristicae: pungent, temperature.Return spleen, stomach, large intestine channel.Warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.For Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite is vomitted.Semen Ziziphi Spinosae: sweet, sour is flat.Return liver, gallbladder, heart channel.Tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.Fructus Schisandrae Chinensis: sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Massa Medicata Fermentata: sweet; Pungent; Temperature; Nontoxic, return spleen; Stomach warp.Invigorating the spleen and regulating the stomach; Promoting digestion and removing stagnation.Main retention of food and drink; Dyspepsia; Distension and fullness in the abdomen; Inappetence; Vomiting dysentery.Fructus Piperis Longi: pungent, heat.Return stomach, large intestine channel.Warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, migraine; External treatment is had a toothache.Ovum crusta Gallus domesticus: light is flat.Convergence antacid, replenishes the calcium.For chronic gastritis, gastric and duodenal ulcers, rickets.
Color ultrasound gastrointestinal contrast agent of the present invention is oral administration, and preferably, its pharmaceutical dosage form can be decoction, granule, powder or syrup.
Two of object of the present invention is the preparation methoies having supplied a kind of color ultrasound gastrointestinal contrast agent, and described contrast agent dosage form is granule, it is characterized in that, comprises following steps:
1) take Margarita 8-20 part, Semen Myristicae 8-20 part, Semen Ziziphi Spinosae 8-20 part, Fructus Schisandrae Chinensis 6-20 part, Massa Medicata Fermentata 6-12 part, Fructus Piperis Longi 2-10 part, Ovum crusta Gallus domesticus 1-8 part respectively, dry, pulverize 120 ~ 200 sieves;
2) by step 1) in pulverize after Chinese medicine powder by the weight mix homogeneously of prescription of the present invention;
3) by step 2) in the Chinese medicine powder of mix homogeneously, granulate, vacuum drying, granulate, obtains granule of the present invention.
Preferably, step 3) vacuum drying temperature is 40-80 DEG C.In experimentation, inventor finds when temperature is more than 80 DEG C, and color ultrasound gastrointestinal contrast agent effect of the present invention is deteriorated, even invalid, therefore baking temperature should not be greater than 80 DEG C.
The present invention is as the usage and dosage of color ultrasound gastrointestinal contrast agent:
By powder 15 ~ 30g of the present invention, be dissolved in 100-300ml60-80 DEG C of boiled water, decoction being taken warmly.
Or powder 15 ~ 30g of the present invention is added appropriate 60-80 DEG C boiled water, and furnishing is dense and burned, swallows, then drink 100-300 temperature boiled water.
Three of object of the present invention is to provide a kind for the treatment of gastric ulcer Chinese medicine composition be prepared from by Margarita, Semen Myristicae, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Massa Medicata Fermentata, Fructus Piperis Longi, Ovum crusta Gallus domesticus, and particularly, it is made up of the raw material of following ratio of weight and number:
Margarita 8-20 part Semen Myristicae 8-20 part Semen Ziziphi Spinosae 8-20 part Fructus Schisandrae Chinensis 6-20 part
Massa Medicata Fermentata 6-12 part Fructus Piperis Longi 2-10 part Ovum crusta Gallus domesticus 1-8 part
Chinese medicine of the present invention, can preferably, be made up of the raw material of following ratio of weight and number:
Margarita 18 parts of Semen Myristicaes 16 parts of Semen Ziziphi Spinosaes 16 parts of Fructus Schisandrae Chinensis 12 parts
Massa Medicata Fermentata 12 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 2 parts
Chinese medicine of the present invention, can also preferably, be made up of the raw material of following ratio of weight and number:
Margarita 14 parts of Semen Myristicaes 8 parts of Semen Ziziphi Spinosaes 16 parts of Fructus Schisandrae Chinensis 8 parts
Massa Medicata Fermentata 8 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 4 parts
Chinese medicine of the present invention, can preferably, be made up of the raw material of following ratio of weight and number again:
Margarita 8 parts of Semen Myristicaes 12 parts of Semen Ziziphi Spinosaes 8 parts of Fructus Schisandrae Chinensis 6 parts
Massa Medicata Fermentata 6 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 6 parts
Four of object of the present invention has supplied a kind of preparation method for the treatment of gastric ulcer Chinese medicine composition, it is characterized in that, comprise following steps:
1) take Margarita 8-20 part, Semen Myristicae 8-20 part, Semen Ziziphi Spinosae 8-20 part, Fructus Schisandrae Chinensis 6-20 part, Massa Medicata Fermentata 6-12 part, Fructus Piperis Longi 2-10 part, Ovum crusta Gallus domesticus 1-8 part respectively, dry, pulverize 120 ~ 200 sieves;
2) by step 1) in pulverize after Chinese medicine powder by the weight mix homogeneously of prescription of the present invention;
3) by step 2) in the Chinese medicine powder of mix homogeneously, granulate, vacuum drying, granulate, obtains granule of the present invention.
Preferably, step 3) vacuum drying temperature is 40-80 DEG C.In experimentation, inventor finds when temperature is more than 80 DEG C, and the present invention treats gastric ulcer Chinese medicine composition effect and is deteriorated, even invalid, therefore baking temperature should not be greater than 80 DEG C.
The present invention treats the usage and dosage of the granule of gastric ulcer: each 6-10g, every day 3 times, within 7 days, be a course for the treatment of, 2 to 3 courses for the treatment of can fully recover.
The present invention compared with prior art has the following advantages:
1. medicine multiple use of the present invention: both can use as contrast agent, again can as the drug use for the treatment of gastric ulcer.
2. medicine of the present invention has no side effect, and uses, do not find anaphylaxis through more than 600 routine patients.
3. medicine of the present invention uses as contrast agent, can antacid pain relieving, easy to use, cost is low, clear picture, the strong reecho of point-like, coat of the stomach clear layer is visible, and the video pictures such as gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature are obvious, and each position focus is high-visible.
4. medicine of the present invention as treatment gastric ulcer drug use time, there is the advantage that consumption is little, short treating period, cure rate are high.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, those skilled in the art; without departing from the inventive concept of the premise; without the need to pay creative work prerequisite under, some changes or replacement can also be made, all should be considered as belonging to protection scope of the present invention.
The preparation of embodiment 1 granule of the present invention:
Take Margarita 18 parts, Semen Myristicae 16 parts, Semen Ziziphi Spinosae 16 parts, Fructus Schisandrae Chinensis 12 parts, Massa Medicata Fermentata 12 parts, Fructus Piperis Longi 8 parts, Ovum crusta Gallus domesticus 2 parts respectively, dry, pulverize 120 sieves; Mix homogeneously; Add cyclodextrin taste masking, granulate, 60 DEG C of vacuum dryings, granulate, obtains granule of the present invention.
The preparation of embodiment 2 granule of the present invention:
Take Margarita 14 parts, Semen Myristicae 8 parts, Semen Ziziphi Spinosae 16 parts, Fructus Schisandrae Chinensis 8 parts, Massa Medicata Fermentata 8 parts, Fructus Piperis Longi 8 parts, Ovum crusta Gallus domesticus 4 parts respectively, dry, pulverize 150 sieves; Mix homogeneously; Add cyclodextrin taste masking, granulate, 60 DEG C of vacuum dryings, granulate, obtains granule of the present invention.
The preparation of embodiment 3 granule of the present invention:
Take Margarita 8 parts, Semen Myristicae 12 parts, Semen Ziziphi Spinosae 8 parts, Fructus Schisandrae Chinensis 6 parts, Massa Medicata Fermentata 6 parts, Fructus Piperis Longi 8 parts, Ovum crusta Gallus domesticus 6 parts respectively, dry, pulverize 120 sieves; Mix homogeneously; Add cyclodextrin taste masking, granulate, 80 DEG C of vacuum dryings, granulate, obtains granule of the present invention.
Embodiment 4 Chinese medicine of the present invention is as the infective use of contrast agent:
Embodiment of the present invention 1-3 granule, takes through 80 routine patient clinicals, and use safety, no pain, without sense of discomfort and anaphylaxis, the review time is short, and imaging efficiency is high, image stabilization, excellent visualization ratio 94.5%, general visualization ratio 5.5%.Can to clarify a diagnosis the various gastrointestinal disease such as superficial gastritis, gastric ulcer, hypertrophic gastritis, prolapse of gastric mucosa, gastric cancer, pyloric part tumor, gastroptosis and duodenitis.Compared with gastroscopy, superficial gastritis diagnostic accordance rate 94%, gastric cancer coincidence rate 88%.
The clinical setting of embodiment 5 treatment by Chinese herbs gastric ulcer of the present invention:
5.1 case selections:
Select patients w ith peptic ulcer disease 200 example to carry out clinical observation, patient is divided into two groups at random, treatment group 100 example, and matched group 100 example, two groups of patient medical record are basically identical, without significant difference, have comparability.
5.2. Therapeutic Method:
Treatment group person suffers from the Chinese medicine granules of the oral embodiment of the present invention 3 preparation, each 6g, and every day 3 times 7 days is a course for the treatment of, takes 3 courses for the treatment of continuously;
Matched group takes omeprazole+amoxicillin+clarithromycin, within 10 days, is a course for the treatment of, takes 2 courses for the treatment of continuously.
5.3 Outcome measure:
Cure: stomach dull pain, dull pain, distending pain, burn the stomach pain such as sample pain and disappear, gastric motility recovers, and metabolism recovers normally.
Take a turn for the better: stomach discomfort alleviates, and gastric motility recovers to some extent.
Invalid: symptom is unchanged.
5.4 therapeutic outcomes:
Treatment group: cure 80 examples, take a turn for the better 18 examples, and invalid 2 examples, cure rate is 80%, and total effective rate is 98%.
Matched group: cure 68 examples, take a turn for the better 20 examples, and invalid 12 examples, cure rate is 68%, and total effective rate is 88%.
The display of above result, the cure rate for the treatment of group and total effective rate are apparently higher than the triple therapy of matched group.
Claims (10)
1. a Chinese medicine composition, is characterized in that, is prepared from by Margarita, Semen Myristicae, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Massa Medicata Fermentata, Fructus Piperis Longi, Ovum crusta Gallus domesticus.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Margarita 8-20 part Semen Myristicae 8-20 part Semen Ziziphi Spinosae 8-20 part Fructus Schisandrae Chinensis 6-20 part
Massa Medicata Fermentata 6-12 part Fructus Piperis Longi 2-10 part Ovum crusta Gallus domesticus 1-8 part.
3. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Margarita 18 parts of Semen Myristicaes 16 parts of Semen Ziziphi Spinosaes 16 parts of Fructus Schisandrae Chinensis 12 parts
Massa Medicata Fermentata 12 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 2 parts.
4. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Margarita 14 parts of Semen Myristicaes 8 parts of Semen Ziziphi Spinosaes 16 parts of Fructus Schisandrae Chinensis 8 parts
Massa Medicata Fermentata 8 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 4 parts.
5. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following ratio of weight and number:
Margarita 8 parts of Semen Myristicaes 12 parts of Semen Ziziphi Spinosaes 8 parts of Fructus Schisandrae Chinensis 6 parts
Massa Medicata Fermentata 6 parts of Fructus Piperis Longi 8 parts of Ovum crusta Gallus domesticuss 6 parts.
6. the Chinese medicine composition as described in as arbitrary in claim 1-5, it is characterized in that, its pharmaceutical dosage form is decoction, granule, powder or syrup, is preferably granule.
7. Chinese medicine composition as claimed in claim 6, it is characterized in that, the preparation method of described granule comprises following steps:
1) take Margarita, Semen Myristicae, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Massa Medicata Fermentata, Fructus Piperis Longi, Ovum crusta Gallus domesticus respectively, dry, pulverize 120 ~ 200 sieves;
2) by step 1) in pulverize after Chinese medicine powder by the weight mix homogeneously of prescription of the present invention;
3) by step 2) in the Chinese medicine powder of mix homogeneously, granulate, vacuum drying, granulate, obtains granule of the present invention.
8. Chinese medicine composition as claimed in claim 7, is characterized in that, the preparation method step 3 of described granule) vacuum drying temperature is 40-80 DEG C.
9. the Chinese medicine composition as described in as arbitrary in claim 1-5, the purposes in preparation treatment Gastric Ulcer Treatment.
10. the Chinese medicine composition as described in as arbitrary in claim 1-5, as the purposes of color ultrasound contrast agent.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984369A (en) * | 2015-07-23 | 2015-10-21 | 王桂霞 | Traditional Chinese medicine composition for preparing color Doppler ultrasound contrast agent, applications and preparation method thereof |
| CN105056254A (en) * | 2015-07-23 | 2015-11-18 | 王桂霞 | Type-B ultrasonography aid and preparation method and applications thereof |
| CN105727317A (en) * | 2016-04-19 | 2016-07-06 | 张艳娟 | Gastrointestinal contrast agent and application thereof |
| CN106540279A (en) * | 2016-04-08 | 2017-03-29 | 青岛辰达生物科技有限公司 | A kind of pharmaceutical preparation of gastrointestinal color ultrasound contrast agent and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688506A (en) * | 2012-06-16 | 2012-09-26 | 山东省千佛山医院 | Gastrointestinal contrast agent containing Chinese herbal extracts |
| CN103830749A (en) * | 2014-03-22 | 2014-06-04 | 济南伟传信息技术有限公司 | Gastrointestinal contrast agent |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688506A (en) * | 2012-06-16 | 2012-09-26 | 山东省千佛山医院 | Gastrointestinal contrast agent containing Chinese herbal extracts |
| CN103830749A (en) * | 2014-03-22 | 2014-06-04 | 济南伟传信息技术有限公司 | Gastrointestinal contrast agent |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984369A (en) * | 2015-07-23 | 2015-10-21 | 王桂霞 | Traditional Chinese medicine composition for preparing color Doppler ultrasound contrast agent, applications and preparation method thereof |
| CN105056254A (en) * | 2015-07-23 | 2015-11-18 | 王桂霞 | Type-B ultrasonography aid and preparation method and applications thereof |
| CN106540279A (en) * | 2016-04-08 | 2017-03-29 | 青岛辰达生物科技有限公司 | A kind of pharmaceutical preparation of gastrointestinal color ultrasound contrast agent and preparation method thereof |
| CN105727317A (en) * | 2016-04-19 | 2016-07-06 | 张艳娟 | Gastrointestinal contrast agent and application thereof |
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