CN103028087A

CN103028087A - Traditional Chinese medicine composition for treating rectal cancer

Info

Publication number: CN103028087A
Application number: CN2012105620069A
Authority: CN
Inventors: 丁常燕
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-12-23
Filing date: 2012-12-23
Publication date: 2013-04-10
Anticipated expiration: 2032-12-23
Also published as: CN103028087B

Abstract

The invention relates to a traditional Chinese medicine composition for treating rectal cancer. The traditional Chinese medicine composition for treating the rectal cancer comprises the following Chinese herbal raw materials in part by weight: 10-30 parts of hedyotis diffusa, 10-30 parts of red ginseng, 10-30 parts of sculellaria barbata, 20-50 parts of astragalus, 10-30 parts of codonopsis pilosula, 10-30 parts of unprocessed rehmannia, 5-25 parts of curcuma zedoary, 5-25 parts of radix polygonati officinalis, 5-25 parts of Chinese yam, 5-25 parts of dwarf lilyturf root, 5-25 parts of medlar, 5-25 parts of glossy privet fruit, 10-30 parts of honeysuckle, 10-30 parts of folium isatidis, 10-30 parts of cortex phellodendri, 10-30 parts of angelica, 10-30 parts of ligusticum wallichii, 10-30 parts of snake gourd fruit, 5-25 parts of fried medicated leaven, 5-25 parts of fried malt, 10-30 parts of fried hawthorn, 10-30 parts of felwort and 10-30 parts of oyster. The traditional Chinese medicine composition has effects of enhancing appetite, strengthening spleen, nourishing liver and kidney, eliminating toxicity, removing lumps, clearing away heat and purging pathogenic fire, and is reliable in therapeutic effect on the rectal cancer, wide in medicinal component source, simple and convenient in preparation, mild in medicinal nature and free of toxic side effect.

Description

A kind of Chinese medicine composition for the treatment of rectal cancer

Technical field

The present invention relates to a kind of pharmaceutical product of not determining structure of traditional herbal medicines, especially a kind of Chinese medicine composition for the treatment of rectal cancer.

Background technology

Rectal cancer refers to that the anus pectinate line is above to divide a word with a hyphen at the end of a line cancer between the section of sigmoid colon and rectum, is the gastrointestinal tract common cancer that sickness rate is only second to gastric cancer.Just the time-out symptom is not obvious for rectal cancer, development defecation frequency to a certain degree occurs afterwards and increases, just not to the utmost sense is arranged, stool is usually with mucus and pus and blood, and along with the cancer piece increases, enteric cavity is narrow gradually, cause feces to attenuate, difficult defecation after the enteric cavity total blockage, the intestinal obstruction symptoms such as constipation abdominal distention, stomachache then occur.At present, what treat rectal cancer all is that operation is main in early days, is equipped with radiotherapy and chemotherapy.Operation no doubt can be excised cancerous protuberance, but also has in residual cancer or regional lymph node metastasis or the blood vessel cancer embolus existence etc., and the relapse and metastasis probability is very high.The radiochemotherapy complication is many, even causes many afunctions, and for late tumor patient, the effect of radiation therapy is not intact.Relatively poor, the older patient of while body constitution, it is more critically ill that continuation radiotherapy can only be led debilitant life, accelerated death.Though chemotherapy has certain short term effect, Chang Yin is with significantly toxicity and side effect, and the catabasis is short, and life quality is poor, can not obviously prolong patient's life cycle.Radiotherapy chemotherapy also can not kill all cancerous cell, and makes cancerous cell and human normal tissue cell simultaneously injured, and easily forms the secondary tumor.

For with the operation of doctor trained in Western medicine, radiotherapy, the methods such as chemotherapy are carried out organic combination, and do not carry out the rectal cancer patient of surgery treatment, adopting the Comprehensive Treatment of Chinese medicine is good method, to prolong the survival of patients time, improves simultaneously cancer patient's quality of life.

Rectal cancer is the categories such as " mass in the abdomen ", " spouting bleeding from anus " that belong in Chinese medicine more.Its cause of disease mostly is eating and drinking without temperance, and addiction to greasy and sweet foods, scorching or unclean thing cause the dysfunction of the spleen, damp and hotly accumulates malicious tenesmus large intestine, thermal burn intestinal network, and poison is evil to be become carbuncle and carcinoma occurs gradually.Control suitable bowel relieving detoxifcation, invigorating spleen and kidney, heat clearing away eliminating stagnation.

According to theory of Chinese medical science, for the pathogeny of rectal cancer, carry out dialectical composition of prescription, to reach the purpose for the treatment of both the principal and secondary aspects of a disease.

Summary of the invention

For overcome in the prior art operation, radiation and chemotherapy easily damages human body and the deficiency of weak curative effect, the invention provides a kind of Chinese medicine composition easy, that cost is low, curative effect is reliable, the treatment that has no side effect is had a headache of preparing.

The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of rectal cancer is characterized in that: its raw material of Chinese medicine by following weight portion forms: Herba Hedyotidis Diffusae 10-30 part, Radix Ginseng Rubra 10-30 part, Herba Scutellariae Barbatae 10-30 part, Radix Astragali 20-50 part, Radix Codonopsis 10-30 part, Radix Rehmanniae 10-30 part, Rhizoma Curcumae 5-25 part, Rhizoma Polygonati Odorati 5-25 part, Rhizoma Dioscoreae 5-25 part, Radix Ophiopogonis 5-25 part, Fructus Lycii 5-25 part, Fructus Ligustri Lucidi 5-25 part, Flos Lonicerae 10-30 part, Folium Isatidis 10-30 part, Cortex Phellodendri 10-30 part, Radix Angelicae Sinensis 10-30 part, Rhizoma Chuanxiong 10-30 part, Fructus Trichosanthis 10-30 part, Massa Medicata Fermentata preparata 5-25 part, Fructus Hordei Germinatus (parched) 5-25 part, Fructus Crataegi (parched) 10-30 part, Radix Gentianae 10-30 part, Concha Ostreae 10-30 part.

The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of rectal cancer is characterized in that: its raw material of Chinese medicine by following weight portion forms: 25 parts of Herba Hedyotidis Diffusaes, 25 parts of Radix Ginseng Rubra, 25 parts of Herba Scutellariae Barbataes, 40 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 20 parts in the Radix Rehmanniae, 15 parts of Rhizoma Curcumae, 15 parts of Rhizoma Polygonati Odorati, 15 parts of Rhizoma Dioscoreaes, 15 parts of Radix Ophiopogonis, 15 parts of Fructus Lyciis, 15 parts of Fructus Ligustri Lucidi, 20 parts of Flos Loniceraes, 20 parts of Folium Isatidiss, 20 parts of Cortex Phellodendris, 20 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Chuanxiongs, 20 parts of Fructus Trichosanthis, 15 parts of Massa Medicata Fermentata preparatas, 15 parts of Fructus Hordei Germinatus (parched)s, 20 parts of Fructus Crataegi (parched), 20 parts of Radix Gentianaes, 20 parts of Concha Ostreaes.

Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected medicament composing prescription.In the Chinese medicine composition of the present invention: Herba Hedyotidis Diffusae has the effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain; Radix Ginseng Rubra has that strongly invigorating primordial QI, multiple arteries and veins take off admittedly, the effect of nourishing qi to stop; Herba Scutellariae Barbatae has the effect of heat-clearing and toxic substances removing, dissipating blood stasis hemostasis, subduing swelling and relieving pain; The Radix Astragali has that benefiting QI for strengthening the superficies, tonifying the lung spleen invigorating, arresting sweating take off admittedly, the effect of wind dispelling fortune poison; Rhizoma Curcumae has the effect of circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving; Rhizoma Polygonati Odorati has the effect of nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst; Rhizoma Dioscoreae has strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow the effect that will is calmed the nerves; Has the effect that YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire Radix Ophiopogonis; Fructus Lycii has the effect of nourishing the liver and kidney, nourishing the liver to improve visual acuity, strengthening the body resistance, spermatogenesis benefit marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing; Fructus Ligustri Lucidi has the effect that nourishing the liver and kidney, tonifying YIN nourish blood; Flos Lonicerae has the effect of heat-clearing and toxic substances removing, wind-heat dissipating; Folium Isatidis has the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis; Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging except the effect of steaming, skin ulcer is treated in detoxifcation; Radix Angelicae Sinensis have enrich blood invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation; Rhizoma Chuanxiong has the effect of blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping; Fructus Trichosanthis has clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes the effect of laxation; Massa Medicata Fermentata preparata has invigorating the spleen and regulating the stomach, the effect in the accent that helps digestion; Fructus Hordei Germinatus (parched) has promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back the effect of newborn relieving distension; Fructus Crataegi (parched) has the effect of dyspepsia and intestinal stasis relieving, phlegm reduction of blood circulation promoting; Radix Gentianae has the effect of heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire; Concha Ostreae has suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion, and hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.The selected medicament composing prescription of the present invention, its drug component be through dialectical compatibility, complements each other using, and has synergism, plays altogether the effect of appetite promoting and the spleen strengthening, nourishing the liver and kidney, detoxicating and resolving stagnation of pathogens, clearing away heat-fire, and rectal cancer is carried out Comprehensive Treatment.

The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, the medicine source is wide, cost is low.The present invention follows the prescriptions principle of the traditional Chinese medical science, and various component drug adopt the usefulness that is decocted in water for oral dose.Through the clinical practice checking, it is evident in efficacy reliable, and the property of medicine is gentle, toxic and side effects do not occur, and effective percentage reaches 90%, cure rate 16%.

The specific embodiment

The invention will be further described below in conjunction with embodiment.

Embodiment 1

A kind of Chinese medicine composition for the treatment of rectal cancer, its raw material of Chinese medicine by following weight proportion forms: Herba Hedyotidis Diffusae 25g, Radix Ginseng Rubra 25g, Herba Scutellariae Barbatae 25g, Radix Astragali 40g, Radix Codonopsis 20g, Radix Rehmanniae 20g, Rhizoma Curcumae 15g, Rhizoma Polygonati Odorati 15g, Rhizoma Dioscoreae 15g, Radix Ophiopogonis 15g, Fructus Lycii 15g, Fructus Ligustri Lucidi 15g, Flos Lonicerae 20g, Folium Isatidis 20g, Cortex Phellodendri 20g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 20g, Fructus Trichosanthis 20g, Massa Medicata Fermentata preparata 15g, Fructus Hordei Germinatus (parched) 15g, Fructus Crataegi (parched) 20g, Radix Gentianae 20g, Concha Ostreae 20g

Embodiment 2

A kind of Chinese medicine composition for the treatment of rectal cancer, its raw material of Chinese medicine by following weight proportion forms: Herba Hedyotidis Diffusae 10g, Radix Ginseng Rubra 20g, Herba Scutellariae Barbatae 30g, Radix Astragali 20g, Radix Codonopsis 15g, Radix Rehmanniae 15g, Rhizoma Curcumae 12g, Rhizoma Polygonati Odorati 25g, Rhizoma Dioscoreae 5g, Radix Ophiopogonis 20g, Fructus Lycii 10g, Fructus Ligustri Lucidi 12g, Flos Lonicerae 15g, Folium Isatidis 25g, Cortex Phellodendri 10g, Radix Angelicae Sinensis 30g, Rhizoma Chuanxiong 10g, Fructus Trichosanthis 25g, Massa Medicata Fermentata preparata 5g, Fructus Hordei Germinatus (parched) 12g, Fructus Crataegi (parched) 15g, Radix Gentianae 10g, Concha Ostreae 25g.

Embodiment 3

A kind of Chinese medicine composition for the treatment of rectal cancer, its raw material of Chinese medicine by following weight proportion forms: Herba Hedyotidis Diffusae 15g, Radix Ginseng Rubra 30g, Herba Scutellariae Barbatae 10g, Radix Astragali 30g, Radix Codonopsis 20g, Radix Rehmanniae 25g, Rhizoma Curcumae 5g, Rhizoma Polygonati Odorati 10g, Rhizoma Dioscoreae 12g, Radix Ophiopogonis 25g, Fructus Lycii 12g, Fructus Ligustri Lucidi 20g, Flos Lonicerae 10g, Folium Isatidis 30g, Cortex Phellodendri 15g, Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 15g, Fructus Trichosanthis 30g, Massa Medicata Fermentata preparata 25g, Fructus Hordei Germinatus (parched) 10g, Fructus Crataegi (parched) 30g, Radix Gentianae 15g, Concha Ostreae 30g.

Embodiment 4

A kind of Chinese medicine composition for the treatment of rectal cancer, its raw material of Chinese medicine by following weight proportion forms: Herba Hedyotidis Diffusae 20g, Radix Ginseng Rubra 15g, Herba Scutellariae Barbatae 20g, Radix Astragali 20g, Radix Codonopsis 30g, Radix Rehmanniae 10g, Rhizoma Curcumae 25g, Rhizoma Polygonati Odorati 12g, Rhizoma Dioscoreae 20g, Radix Ophiopogonis 5g, Fructus Lycii 25g, Fructus Ligustri Lucidi 5g, Flos Lonicerae 30g, Folium Isatidis 10g, Cortex Phellodendri 25g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 30g, Fructus Trichosanthis 10g, Massa Medicata Fermentata preparata 20g, Fructus Hordei Germinatus (parched) 5g, Fructus Crataegi (parched) 25g, Radix Gentianae 25g, Concha Ostreae 15g.

Embodiment 5

A kind of Chinese medicine composition for the treatment of rectal cancer, its raw material of Chinese medicine by following weight proportion forms: Herba Hedyotidis Diffusae 30g, Radix Ginseng Rubra 10g, Herba Scutellariae Barbatae 15g, Radix Astragali 35g, Radix Codonopsis 10g, Radix Rehmanniae 30g, Rhizoma Curcumae 10g, Rhizoma Polygonati Odorati 5g, Rhizoma Dioscoreae 25g, Radix Ophiopogonis 10g, Fructus Lycii 5g, Fructus Ligustri Lucidi 25g, Flos Lonicerae 25g, Folium Isatidis 15g, Cortex Phellodendri 30g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 25g, Fructus Trichosanthis 15g, Massa Medicata Fermentata preparata 12g, Fructus Hordei Germinatus (parched) 25g, Fructus Crataegi (parched) 10g, Radix Gentianae 30g, Concha Ostreae 10g.

Chinese medicine composition in embodiment of the invention decocting method is routinely produced medicament.Concrete grammar is as follows: the raw material of Chinese medicine of prescription is put into container, add cold water and cover powder, soaked 15～20 minutes, add water again and do not have about 5 centimetres of powder, decoct.Adopt intense fire to decoct at a simmer, it is rear with slow fire boiling 20～30 minutes to boil; Second decocts, and adds water and does not have about 4 centimetres of powder, the water rear decoction 15～20 minutes of boiling.Decoct extracting juice twice, merge.

A kind of Chinese medicine composition for the treatment of rectal cancer, clinical efficacy is summed up:

One, general data: this Chinese medicine composition is applied to clinical observation case 50 examples, 45～75 years old age.

Two, usage and dosage: during clinical practice, the component in the compositions is taken the circumstances into consideration increase and decrease according to patient's body weight and age.Potion on the one, the about 300ml of twice extracting juice of decocting divides early, takes for late twice.Ten days is a course for the treatment of.

Three, criterion of therapeutical effect:

1, alleviate fully: visible neoplastic lesion complete obiteration, keep more than 4 weeks;

2, partial rcsponse: the product of the vertical transverse diameter of the maximum gauge of tumor focus and maximum thereof dwindles more than 50%, and other focuses occur without new focus without increase, keep more than 4 weeks;

3, stable or unchanged: two footpath products of tumor focus dwindle less than 50%, or increase and be no more than 25%, occur without new focus, keep more than 4 weeks;

4, progress: two footpath products of tumor focus increase more than 25% or new focus occurs.

Four, therapeutic effect: in this clinical observation case, take medicine 3-10 the course for the treatment of, alleviate 8 examples fully, partial rcsponse 20 examples, stable or unchanged 12 examples are made progress 10 examples.Toxic and side effects does not occur during the treatment.

Five, model case:

Case 1:

Zhang, man, 49 years old.Private prosecution: uncomfortable, times of defecation increases, and feces attenuates, and the sticking blood of band has defecation to feel not to the utmost, and ultrasonic scanning and pathological tissues pathologic finding are diagnosed as rectal cancer in the per rectum.Take 3 courses for the treatment of of medicament of Chinese medicine composition preparation of the present invention, focus is dwindled, and continues to take 2 courses for the treatment of, and focus is obviously improved, and focus has dwindled 60%, keeps the new focus of above nothing of 4 weeks and occurs.

Case 2:

Soup, woman, 68 years old.Stool abnormity difficulty goes examination in hospital to be diagnosed as rectal cancer, have wellability to shift and with the bladder adhesion, because operation can't be accomplished radical treatment, and advanced in years, carry out the Chinese medicine expectant treatment.Take 3 courses for the treatment of of medicament of Chinese medicine composition of the present invention preparation, stool is normal, checks after continuing to take 3 courses for the treatment of, turns rectum position tumor and has dwindled many; Again 2 courses for the treatment of of after treatment, the state of an illness is alleviated fully.

Claims

1. Chinese medicine composition for the treatment of rectal cancer, it is characterized in that: its raw material of Chinese medicine by following weight portion forms: Herba Hedyotidis Diffusae 10-30 part, Radix Ginseng Rubra 10-30 part, Herba Scutellariae Barbatae 10-30 part, Radix Astragali 20-50 part, Radix Codonopsis 10-30 part, Radix Rehmanniae 10-30 part, Rhizoma Curcumae 5-25 part, Rhizoma Polygonati Odorati 5-25 part, Rhizoma Dioscoreae 5-25 part, Radix Ophiopogonis 5-25 part, Fructus Lycii 5-25 part, Fructus Ligustri Lucidi 5-25 part, Flos Lonicerae 10-30 part, Folium Isatidis 10-30 part, Cortex Phellodendri 10-30 part, Radix Angelicae Sinensis 10-30 part, Rhizoma Chuanxiong 10-30 part, Fructus Trichosanthis 10-30 part, Massa Medicata Fermentata preparata 5-25 part, Fructus Hordei Germinatus (parched) 5-25 part, Fructus Crataegi (parched) 10-30 part, Radix Gentianae 10-30 part, Concha Ostreae 10-30 part.

2. a kind of Chinese medicine composition for the treatment of rectal cancer according to claim 1, it is characterized in that: its raw material of Chinese medicine by following weight portion forms: 25 parts of Herba Hedyotidis Diffusaes, 25 parts of Radix Ginseng Rubra, 25 parts of Herba Scutellariae Barbataes, 40 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 20 parts in the Radix Rehmanniae, 15 parts of Rhizoma Curcumae, 15 parts of Rhizoma Polygonati Odorati, 15 parts of Rhizoma Dioscoreaes, 15 parts of Radix Ophiopogonis, 15 parts of Fructus Lyciis, 15 parts of Fructus Ligustri Lucidi, 20 parts of Flos Loniceraes, 20 parts of Folium Isatidiss, 20 parts of Cortex Phellodendris, 20 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Chuanxiongs, 20 parts of Fructus Trichosanthis, 15 parts of Massa Medicata Fermentata preparatas, 15 parts of Fructus Hordei Germinatus (parched)s, 20 parts of Fructus Crataegi (parched), 20 parts of Radix Gentianaes, 20 parts of Concha Ostreaes.