CN104491078A - Traditional Chinese medicine tablets for treating rectal cancer - Google Patents
Traditional Chinese medicine tablets for treating rectal cancer Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine tablets for treating rectal cancer, which relate to the technical field of rectal cancer treatment medicines and are mainly used for solving the technical problems of high relapse rate of rectal cancer, no disease cure but symptom cure and long treatment course. The traditional Chinese medicine tablets are prepared from the following raw materials in parts by mass: 30-40 parts of spreading hedyotis herb, 10-25 parts of Chinese angelica, 20-40 parts of radix astragali, 30-40 parts of dianthus superbus, 10-18 parts of papaya, 5-20 parts of peach seed, 15-25 parts of cassia twig, 10-20 parts of rhizoma corydalis, 20-30 parts of sargentg loryvine, 10-25 parts of glium aparine, 20-30 parts of semen platycladi, 5-15 parts of folium isatidis, 2-20 parts of radix glycyrrhizae and 15-30 parts of akebia stem. The traditional Chinese medicine tablets for treating rectal cancer can effectively improve the intestinal environment and promote the disappearance of rectal cancer symptoms; and clinical practice indicates that the total effective rate exceeds 90% when the traditional Chinese medicine tablets are used for treating rectal cancer while no toxic or side effect occurs.
Description
Technical field
The present invention relates to treatment rectal cancer technical field of pharmaceuticals, specifically a kind of Chinese medicinal tablet for the treatment of rectal cancer.
Background technology
Rectal cancer refers to that more than anus pectinate line is to the cancer between sigmoid colon and rectum moving part, is the gastrointestinal tract common cancer that sickness rate is only second to gastric cancer.Rectal cancer initial symptoms is not obvious, has blood in stool, drains mucus, chronic diarrhea along with PD can engender, later stage cancer block increases gradually, and enteric cavity is narrow gradually, causes difficult defecation, occurs the symptoms such as stomachache, anemia.
In the traditional Chinese medical science, the cause of disease of rectal cancer is summed up as eating and drinking without temperance more, and addiction to greasy and sweet foods, scorching or unclean thing, cause the dysfunction of the spleen, damp and hotly accumulates malicious tenesmus large intestine, thermal burn intestinal network and gradually carcinoma occurs.Treatment at present for rectal cancer adopts excision to be main more, auxiliary treatment is carried out in combined with chemotherapy and radiotherapy, this therapeutic modality is long for the course for the treatment of, recurrence probability is higher, for the patient that body constitution in late period is poor, easily accelerate the deterioration of the state of an illness, and Radiotherapy chemotherapy treatment can not improve patient body's environment, cure the symptoms, not the disease, certain limitation is brought to the treatment of rectal cancer.
Summary of the invention
The object of the invention is recurrence probability in order to solve existing treatment rectal cancer high, cure the symptoms, not the disease, problem that the course for the treatment of is long, and a kind of Chinese medicinal tablet for the treatment of rectal cancer provided.
The technical solution used in the present invention is: a kind of Chinese medicinal tablet for the treatment of rectal cancer, is made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 30 ~ 40 parts, Radix Angelicae Sinensis 10 ~ 25 parts, the Radix Astragali 20 ~ 40 parts, Herba Dianthi 30 ~ 40 parts, Fructus Caricae 10 ~ 18 parts, 5 ~ 20 parts, Semen Persicae, Ramulus Cinnamomi 15 ~ 25, Rhizoma Corydalis 10 ~ 20, Caulis Sargentodoxae 20 ~ 30, Herba Galii Teneri 10 ~ 25, Semen Platycladi 20 ~ 30 parts, Folium Isatidis 5 ~ 15 parts, 2 ~ 20 parts, Radix Glycyrrhizae, Caulis Akebiae 15 ~ 30 parts.
Further, treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 33 ~ 38 parts, Radix Angelicae Sinensis 15 ~ 20 parts, the Radix Astragali 24 ~ 35 parts, Herba Dianthi 33 ~ 37 parts, Fructus Caricae 12 ~ 16 parts, 10 ~ 15 parts, Semen Persicae, Ramulus Cinnamomi 18 ~ 22, Rhizoma Corydalis 13 ~ 17, Caulis Sargentodoxae 23 ~ 28, Herba Galii Teneri 15 ~ 20, Semen Platycladi 22 ~ 28 parts, Folium Isatidis 7 ~ 11 parts, 7 ~ 15 parts, Radix Glycyrrhizae, Caulis Akebiae 19 ~ 26 parts.
Further, treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 36 parts, Radix Angelicae Sinensis 17 parts, the Radix Astragali 30 parts, Herba Dianthi 35 parts, Fructus Caricae 15 parts, 14 parts, Semen Persicae, Ramulus Cinnamomi 20, Rhizoma Corydalis 15, Caulis Sargentodoxae 25, Herba Galii Teneri 17, Semen Platycladi 26 parts, Folium Isatidis 10 parts, 11 parts, Radix Glycyrrhizae, Caulis Akebiae 23 parts.
Method for preparing tablet thereof comprises the steps: after each for Chinese medicine components in mass portion number ratio mixing, adding the mass concentration accounting for medicine gross mass 8 times amount is the ethanol of 70%, then reflux, extract, 3 times, each 1 hour, merge extractive liquid, also cools 10min, again through 16 layers of filtered through gauze, filtrate concentrates at outer circulation concentrator, concentrated condition is: pressure 0.03Mpa, temperature 70 C, be concentrated into the extractum that relative density is 1.13, extractum and the starch Homogeneous phase mixing accounting for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, tablet is pressed into tablet machine.
Instructions of taking: being grown up every day 1,4 weeks is a course for the treatment of.
A kind of medical material effect for the treatment of in the Chinese medicinal tablet of rectal cancer of the present invention is resolved as follows:
Herba Hedyotidis Diffusae bitter in the mouth, light, cold in nature, function is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness, large quantity research shows, has Multiple components to have anti-tumor activity in Herba Hedyotidis Diffusae, comprises total flavones, total polysaccharides, triterpenes, stigmasterol, cupreol, oleanolic acid and ursolic acid etc.Radix Angelicae Sinensis sweet in the mouth, warm in nature, function for invigorating blood circulation, menstruction regulating and pain relieving, moisturize laxation, from Radix Angelicae Sinensis in isolated chemical composition, be important constituent with volatile oil, be secondly organic acid and several amino acids and trace element, modern pharmacological research shows, the liposoluble constituent of Radix Angelicae Sinensis has the effect of performance antiinflammatory antioxidative, and can intervene the development of colorectal cancer.Radix Astragali sweet in the mouth, slightly warm in nature, function is weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, to have blood in stool metrorrhagia, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, modern pharmacological research shows, the Radix Astragali, by lowering immunosuppression molecule such as colorectal cancer cell secretion TGF β-1 grade, affects the performance of its immunosuppressive effect, realizes the object of anti-rectal cancer tumor.Herba Dianthi bitter in the mouth, cold in nature, function is clearing away heat and promoting diuresis, invigorates blood circulation, and for urinary tract infection, calculus, carbuncle, amenorrhea, modern pharmacological research shows, Herba Dianthi decoct has the excitation shown to intestinal tube, strengthens enterokinesia ability.Fructus Caricae sweet in the mouth, property are flat, function is invigorating the stomach and promoting digestion, channels sootheing and network vessel quickening, for weakness of the spleen and stomach, inappetence, Fengshi Guanjie pain, numb limbs and tense tendons, taste-blindness rate, it is containing carpaine, papain, beta-carotene, δ-carotene, lycopene, Fructus Caricae water-soluble fibre contributes to digestion, can improve constipation, improve rectal cancer symptom.Semen Persicae sweet in the mouth, warm in nature, function is blood stasis removing and clots absorbing, moisturizes laxation, and modern pharmacological research shows, the vitamin B group in Semen Persicae can the secretion of facilitating digestion liquid, and cellulose can maintain and promote the wriggling of intestinal wall, helps digest.Ramulus Cinnamomi sweet in the mouth, warm in nature, function diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Rhizoma Corydalis bitter in the mouth, warm in nature, function is invigorated blood circulation, dissipating blood stasis, regulate the flow of vital energy, pain relieving, all pains of main trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Caulis Sargentodoxae bitter in the mouth, property are flat, and tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness, disinsection efficiency, cures mainly acute appendicitis, dysentery, mastalgia, dysmenorrhea, amenorrhea, traumatic injury, rheumatic arthralgia, abdominal pain due to worm stagnation.Herba Galii Teneri acrid in the mouth, cold nature, function heat-clearing and toxic substances removing inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain, cures mainly swollen ulcer drug, urinary tract infection, hematuria, gingival hemorrhage, and knife injury is hemorrhage.Semen Platycladi sweet in the mouth, property are flat, and function is tranquilizing by nourishing the heart, loosening bowel to relieve constipation, the diseases such as it is for restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine constipation.Folium Isatidis bitter in the mouth, cold in nature, function is heat-clearing and toxic substances removing, cooling blood for hemostasis, cures mainly fever caused by exogenous pathogenic factors, maculae caused by violent heat pathogen, intenseness of heat excessive thirst, laryngopharynx swelling and pain, aphtha, sore throat, mumps erysipelas, jaundice, pyrotoxic dysentery, acute enteritis, swollen ulcer drug, epistaxis, stranguria with blood, traumatic hemorrhage.Radix Glycyrrhizae sweet in the mouth, property are flat, Radix Glycyrrhizae contains number of chemical composition, function is replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, and its main component has glycyrrhizic acid, liquiritin etc., and wherein glycyrrhizin, glycyrrhetate have anti-inflammatory and antiallergic, anticancer effect.Caulis Akebiae bitter in the mouth, cold nature, function pathogenic fire purging row water, promoting blood circulation, modern pharmacological research shows, Caulis Akebiae decoct is to treatment dysuria, and edema, irritable feverish sensation in the chest, dizzy pharyngalgia is respond well.
The present invention has following beneficial effect:
One, medicine of the present invention, Herba Hedyotidis Diffusae, Radix Angelicae Sinensis, the Radix Astragali can suppress the development of rectal cancer tumor; Herba Dianthi, Fructus Caricae, Semen Persicae, Ramulus Cinnamomi, Rhizoma Corydalis, Caulis Sargentodoxae, Herba Galii Teneri, Semen Platycladi, Folium Isatidis, Radix Glycyrrhizae, Caulis Akebiae increase gastrointestinal motility, replenishing QI to invigorate the spleen, improve patient body's environment, alleviate have blood in stool, drain mucus, the symptom such as defecation blocks, chronic diarrhea, stomachache, anemia, inappetence.
Two, medicine of the present invention, focuses on the integrally-regulated of human body, takes stopgap measures and effects a permanent cure with executing; And formula Chinese crude drug is easy to get, each medical material all has no side effect, and long-term taking also can not damage internal organs, and drug dependence is less, and medication is safer.
Three, medicine of the present invention, to rectal cancer determined curative effect, effectively can reduce the harm that rectal cancer brings, effective percentage, more than 90%, is worth at clinical expansion.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated.
Embodiment 1:
Treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 30 parts, Radix Angelicae Sinensis 10 parts, the Radix Astragali 30 parts, Herba Dianthi 30 parts, Fructus Caricae 10 parts, 5 parts, Semen Persicae, Ramulus Cinnamomi 15, Rhizoma Corydalis 10, Caulis Sargentodoxae 20, Herba Galii Teneri 10, Semen Platycladi 20 parts, Folium Isatidis 5 parts, 2 parts, Radix Glycyrrhizae, Caulis Akebiae 15 parts.
Tablet preparation and instructions of taking: after each for Chinese medicine components in mass portion number ratio mixing, adding the mass concentration accounting for medicine gross mass 8 times amount is the ethanol of 70%, then reflux, extract, 3 times, each 1 hour, merge extractive liquid, also cools 10min, again through 16 layers of filtered through gauze, filtrate concentrates at outer circulation concentrator, concentrated condition is: pressure 0.03Mpa, temperature 70 C, be concentrated into the extractum that relative density is 1.13, extractum and the starch Homogeneous phase mixing accounting for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, tablet is pressed into tablet machine.Being grown up every day 1,4 weeks is a course for the treatment of.
Embodiment 2:
Treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 40 parts, Radix Angelicae Sinensis 25 parts, the Radix Astragali 40 parts, Herba Dianthi 40 parts, Fructus Caricae 18 parts, 20 parts, Semen Persicae, Ramulus Cinnamomi 25, Rhizoma Corydalis 20, Caulis Sargentodoxae 30, Herba Galii Teneri 25, Semen Platycladi 20 parts, Folium Isatidis 15 parts, 20 parts, Radix Glycyrrhizae, Caulis Akebiae 30 parts.
The method for preparing tablet thereof of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3:
Treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 33 parts, Radix Angelicae Sinensis 15 parts, the Radix Astragali 24 parts, Herba Dianthi 33 parts, Fructus Caricae 12 parts, 10 parts, Semen Persicae, Ramulus Cinnamomi 18, Rhizoma Corydalis 13, Caulis Sargentodoxae 23, Herba Galii Teneri 15, Semen Platycladi 22 parts, Folium Isatidis 7 parts, 7 parts, Radix Glycyrrhizae, Caulis Akebiae 19 parts.
The preparation method of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4:
Treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 38 parts, Radix Angelicae Sinensis 20 parts, the Radix Astragali 35 parts, Herba Dianthi 37 parts, Fructus Caricae 16 parts, 15 parts, Semen Persicae, Ramulus Cinnamomi 22, Rhizoma Corydalis 17, Caulis Sargentodoxae 28, Herba Galii Teneri 20, Semen Platycladi 28 parts, Folium Isatidis 11 parts, 15 parts, Radix Glycyrrhizae, Caulis Akebiae 26 parts.
The method for preparing tablet thereof of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5:
Treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 36 parts, Radix Angelicae Sinensis 17 parts, the Radix Astragali 30 parts, Herba Dianthi 35 parts, Fructus Caricae 15 parts, 14 parts, Semen Persicae, Ramulus Cinnamomi 20, Rhizoma Corydalis 15, Caulis Sargentodoxae 25, Herba Galii Teneri 17, Semen Platycladi 26 parts, Folium Isatidis 10 parts, 11 parts, Radix Glycyrrhizae, Caulis Akebiae 23 parts.
The method for preparing tablet thereof of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 6:
Treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 39 parts, Radix Angelicae Sinensis 23 parts, the Radix Astragali 35 parts, Herba Dianthi 37 parts, Fructus Caricae 17 parts, 19 parts, Semen Persicae, Ramulus Cinnamomi 19, Rhizoma Corydalis 15, Caulis Sargentodoxae 26, Herba Galii Teneri 18, Semen Platycladi 28 parts, Folium Isatidis 14 parts, 15 parts, Radix Glycyrrhizae, Caulis Akebiae 26 parts.
The method for preparing tablet thereof of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 7:
Treat a Chinese medicinal tablet for rectal cancer, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 32 parts, Radix Angelicae Sinensis 25 parts, the Radix Astragali 21 parts, Herba Dianthi 30 parts, Fructus Caricae 18 parts, 24 parts, Semen Persicae, Ramulus Cinnamomi 21, Rhizoma Corydalis 16, Caulis Sargentodoxae 27, Herba Galii Teneri 19, Semen Platycladi 28 parts, Folium Isatidis 15 parts, 3 parts, Radix Glycyrrhizae, Caulis Akebiae 30 parts.
The method for preparing tablet thereof of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data and case:
In order to show therapeutic effect of the present invention, system clinical observation treatment being carried out to 100 routine rectal cancer patients, in the process of above-mentioned clinical observation, record being carried out to the medical history of above-mentioned patient, the state of an illness and curative effect.
Clinical therapeutic efficacy criterion is:
Cure: common sign as mucus of having blood in stool, drain, defecation block, chronic diarrhea, stomachache, anemia, inappetence etc. all disappear.
Take a turn for the better: subjective symptoms as mucus of having blood in stool, drain, defecation block, chronic diarrhea, stomachache, anemia, inappetence disappear substantially.
Invalid: symptom, sign are not improved.
Therapeutic effect: a kind of Chinese prescription for the treatment of insufficiency of heart-QI of the present invention is treated through 100 routine rectum patients, 52 example recoveries from illness, 39 examples take a turn for the better, and 9 examples are invalid, and total effective rate reaches 91%.
Model case:
Case 1: patient Jiang, man, 48 years old, found dyschesia before half a year, be diagnosed as rectal cancer, and cancer cell metastasis is to abdominal cavity, can not performs the operation to examination in hospital.After taking 3 courses for the treatment of of Chinese medicinal tablet of the present invention, check finds that focus has had and obviously reduces, and after continuing to take 4 courses for the treatment of of Chinese medicinal tablet of the present invention, symptom disappears completely, follows up a case by regular visits to and does not recur for 1 year.
Case 2: patient Lee, female, 40 years old.Patient goes to toilet 5,6 every day, defecates rare, and after having pain after an action of the bowels, the pain increased afterwards, admission examination, and mucosal erosion just blood is shown in by enteroscope, and CT detects enclosed mass, is diagnosed as rectal cancer 3 phase further.After taking 2 courses for the treatment of of Chinese medicinal tablet of the present invention, check finds that tumor has had and obviously reduces, and after continuing to take 5 courses for the treatment of of Chinese medicinal tablet of the present invention, symptom disappears completely, follows up a case by regular visits to and does not recur for 1 year.
Case 3: grandson patient so-and-so, man, 38 years old.Patient's constipation alternately occurs with diarrhoea, and the later stage has blood in stool seriously, is mucosanguineous feces sometimes, weak from head to foot, and inappetence is rectal cancer to hospital diagnosis.After taking 2 courses for the treatment of of Chinese medicinal tablet of the present invention, defecate smooth and easy, can suitable out-of-bed activity, after continuing to take 4 courses for the treatment of of Chinese medicinal tablet of the present invention, malaise symptoms disappears completely, follows up a case by regular visits to and does not recur for 1 year.
Claims (3)
1. treat the Chinese medicinal tablet of rectal cancer for one kind, it is characterized in that, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 30 ~ 40 parts, Radix Angelicae Sinensis 10 ~ 25 parts, the Radix Astragali 20 ~ 40 parts, Herba Dianthi 30 ~ 40 parts, Fructus Caricae 10 ~ 18 parts, 5 ~ 20 parts, Semen Persicae, Ramulus Cinnamomi 15 ~ 25, Rhizoma Corydalis 10 ~ 20, Caulis Sargentodoxae 20 ~ 30, Herba Galii Teneri 10 ~ 25, Semen Platycladi 20 ~ 30 parts, Folium Isatidis 5 ~ 15 parts, 2 ~ 20 parts, Radix Glycyrrhizae, Caulis Akebiae 15 ~ 30 parts.
2. a kind of Chinese medicinal tablet for the treatment of rectal cancer according to claim 1, it is characterized in that, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 33 ~ 38 parts, Radix Angelicae Sinensis 15 ~ 20 parts, the Radix Astragali 24 ~ 35 parts, Herba Dianthi 33 ~ 37 parts, Fructus Caricae 12 ~ 16 parts, 10 ~ 15 parts, Semen Persicae, Ramulus Cinnamomi 18 ~ 22, Rhizoma Corydalis 13 ~ 17, Caulis Sargentodoxae 23 ~ 28, Herba Galii Teneri 15 ~ 20, Semen Platycladi 22 ~ 28 parts, Folium Isatidis 7 ~ 11 parts, 7 ~ 15 parts, Radix Glycyrrhizae, Caulis Akebiae 19 ~ 26 parts.
3. a kind of Chinese medicinal tablet for the treatment of rectal cancer according to claim 1, it is characterized in that, be made up of the raw material of following mass fraction: Herba Hedyotidis Diffusae 36 parts, Radix Angelicae Sinensis 17 parts, the Radix Astragali 30 parts, Herba Dianthi 35 parts, Fructus Caricae 15 parts, 14 parts, Semen Persicae, Ramulus Cinnamomi 20, Rhizoma Corydalis 15, Caulis Sargentodoxae 25, Herba Galii Teneri 17, Semen Platycladi 26 parts, Folium Isatidis 10 parts, 11 parts, Radix Glycyrrhizae, Caulis Akebiae 23 parts.
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| CN104784343A (en) * | 2015-05-05 | 2015-07-22 | 黄玉莲 | Preparation with effects of clearing away heat and toxic materials for patients suffering from rectal cancer and preparation method thereof |
| CN105287890A (en) * | 2015-11-25 | 2016-02-03 | 代治华 | Traditional Chinese medicine preparation for treating rectal cancer and preparation method thereof |
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| CN103877384A (en) * | 2014-04-05 | 2014-06-25 | 柳桂玉 | Traditional Chinese medicine preparation for treating rectal cancer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784343A (en) * | 2015-05-05 | 2015-07-22 | 黄玉莲 | Preparation with effects of clearing away heat and toxic materials for patients suffering from rectal cancer and preparation method thereof |
| CN105287890A (en) * | 2015-11-25 | 2016-02-03 | 代治华 | Traditional Chinese medicine preparation for treating rectal cancer and preparation method thereof |
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