CN103356959B - Pharmaceutical composition for treating hyperplasia of mammary glands - Google Patents
Pharmaceutical composition for treating hyperplasia of mammary glands Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating hyperplasia of mammary glands. The pharmaceutical composition is prepared from the following Chinese herbal medicine raw materials in parts by weight: 8-80 parts of sophora flower, 8-80 parts of radix achyranthis bidentatae, 12-120 parts of artemisia lactiflora, 12-120 parts of hawthorn, 12-120parts of motherwort, 12-120 parts of square-stem, 8-120 parts of radix curcumae, 12-120 parts of root of common peony, 4-40 parts of root of three-nerved spicebush, 8-80 parts of fructus polygoni orientalis, 8-80 parts of ligusticum wallichii, 8-80 parts of angelica sinensis, 8-80 parts of tangerine leaf, and 8-80 parts of artemisia anomala. The pharmaceutical composition disclosed by the invention has significant treatment effect on the hyperplasia disease of mammary glands; the total effective rate is over 97%; and meanwhile, the treatment time is greatly shortened.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of pharmaceutical composition for the treatment of cyclomastopathy.
Background technology
Cyclomastopathy is a kind of non-tumor the most common in disease of hyperplasia of mammary glands glands, the proliferative lesion of non-inflammation, all accounts for about 70% in cystic hyperplasia of breast, can betide the women at adolescence later any age.
The traditional Chinese medical science is thought, this sick pathogenic factor many with internal organs dysfunction, qi-blood disharmony relevant, the liver spleen of pathological changes internal organs duty, especially the spleen soil people of weakness or the pungent delicious food savoury of surfeit, damage spleen soil, and it is not normal to cause the native transportation capabilities of spleen, gathering wets as expectorant or innately introverted, emotion is constrained, and good sulky or irascible temperament, dynamic then irritability or because of damaged by excess of seven emotions, be worried excessively, and cause the liver failing to maintain the normal flow of QI, Yu Ercheng expectorant etc., all can cause phlegm-damp to be tied poly-, coagulation of QI-blood and form lump.
Summary of the invention
The object of the present invention is to provide the pharmaceutical composition of a kind of short treating period, treatment cyclomastopathy evident in efficacy.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for cyclomastopathy, be made up of the traditional Chinese medicinal material raw materials of following weight portion: Flos Sophorae 8-80 part, Radix Achyranthis Bidentatae 8-80 part, Artemisia lactiflora Wall. 12-120 part, Fructus Crataegi 12-120 part, Herba Leonuri 12-120 part, Spica Prunellae 12-120 part, Radix Curcumae 8-120 part, Radix Paeoniae Rubra 12-120 part, Radix Linderae 4-40 part, Fructus Polygoni Orientalis 8-80 part, Rhizoma Chuanxiong 8-80 part, Radix Angelicae Sinensis 8-80 part, Folium Citri tangerinae 8-80 part, Herba Artemisiae Anomalae 8-80 part.
In the present invention's preferred embodiment, the pharmaceutical composition of described treatment cyclomastopathy is made up of the traditional Chinese medicinal material raw materials of following weight portion: 10 parts, Flos Sophorae, Radix Achyranthis Bidentatae 10 parts, Artemisia lactiflora Wall. 15 parts, Fructus Crataegi 15 parts, Herba Leonuri 15 parts, Spica Prunellae 15 parts, Radix Curcumae 10 parts, Radix Paeoniae Rubra 15 parts, the Radix Linderae 6 parts, Fructus Polygoni Orientalis 10 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Sinensis 10 parts, Folium Citri tangerinae 10 parts, Herba Artemisiae Anomalae 10 parts.
The pharmaceutical composition of any one treatment cyclomastopathy above-mentioned, it can be made into oral liquid, granule, tablet, capsule; Preferably, the pharmaceutical composition of any one treatment cyclomastopathy above-mentioned, it is made into oral liquid.
According to Chinese medicine Historical Data Data About, above-mentioned traditional Chinese medicinal material raw materials has following pharmacologically active:
Flos Sophorae: cooling blood for hemostasis; Liver heat removing and eyesight improving.Main discharging fresh blood stool; Hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; Liver-heat is had a headache; Conjunctival congestion and swelling pain; Carbuncle skin infection.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, has a headache dizzy.
Radix Achyranthis Bidentatae: invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite that (blood) is descending, inducing diuresis for treating stranguria syndrome.Cure mainly soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal abdominal pain due to blood stasis, lump in the abdomen, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, laryngopharynx swelling and pain.Select the root of amaranthaceous plant Radix Achyranthis Bidentatae.
Artemisia lactiflora Wall.: all herbal medicine, have heat clearing away, removing toxic substances, cough-relieving, antiinflammatory, invigorate blood circulation, dissipating blood stasis, the effect such as to stimulate the menstrual flow, be usually used in treating the liver, kidney diaseases.
Fructus Crataegi: appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.Select the dry mature fruit of rosaceous plant Fructus Crataegi Crataegus pinnatifida Bge..
Herba Leonuri: promoting blood flow to regulate menstruation, for amenorrhea due to stagnation of blood, dysmenorrhea, blockage of menstruation, the stagnant stomachache of prolonged lochia, the stasis of blood.Fresh or the dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..
Spica Prunellae: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.Select the dry fruit ear of labiate Spica Prunellae Prunella vulgaris L..
Radix Curcumae: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Select the dried root of zingiberaceous plant Rhizoma Curcumae Longae.
Radix Paeoniae Rubra: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Select the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.
The Radix Linderae: pleasant, dissipating depression of QI, cold expelling, pain relieving.Control QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.Be selected from the tuber of canella Radix Linderae Lindera aggregata (Sims) Kosterm..
Fructus Polygoni Orientalis: have eliminating mass and relieving fullness eliminating stagnation, clearing away heat to alleviate pain function.For mass in the abdomen abdominal distention, hepatosplenomegaly, the tuberculosis of cervical lymph nodes, quenches one's thirst, stomachache.Suitable amount used externally is endured cream or is smash long-pending, invigorating spleen to remove dampness.Control flank disease amassing, dropsy, has a stomach-ache, lack of appetite abdominal distention, acute catarrhal conjunctivitis, and skin ulcer swells, scrofula.Select the dry mature fruit of polygonaceae plant smartweed PolygonumorientaleLinn..
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive wind syndrome of head headache, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Select the rhizome of samphire Rhizoma Chuanxiong.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Select the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.
Folium Citri tangerinae: soothing the liver, circulation of qi promoting, reduces phlegm, detumescence poison.Control hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.Select the leaf of the multiple Fructus Citri tangerinae class such as leaf or Zhu's Fructus Citri tangerinae of rutaceae orange Citrus reticulata Blanco.
Herba Artemisiae Anomalae: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.Select the herb of feverfew artemisia anomalas.
By the preparation method that above-mentioned each Chinese medicinal components is prepared into oral liquid of the present invention be:
(1) get the Flos Sophorae of recipe quantity, Radix Achyranthis Bidentatae, Artemisia lactiflora Wall., Fructus Crataegi, Herba Leonuri, Spica Prunellae, Radix Curcumae, Radix Paeoniae Rubra, the Radix Linderae, Fructus Polygoni Orientalis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Folium Citri tangerinae and Herba Artemisiae Anomalae, clean roguing, dry, pulverize;
(2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, the water of first time totalling medical material 8-10 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6-8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration contains 2-3g crude drug amount to every milliliter, set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is filtered, add or pack after not adding correctives and obtain oral liquid.
Compared with prior art, the medicine composite for curing cyclomastopathy disease that the present invention relates to evident in efficacy, total effective rate reaches more than 97%, and treatment time significantly shortens simultaneously.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: 100 grams, Flos Sophorae, Radix Achyranthis Bidentatae 100 grams, Artemisia lactiflora Wall. 150 grams, Fructus Crataegi 150 grams, Herba Leonuri 150 grams, Spica Prunellae 150 grams, Radix Curcumae 100 grams, Radix Paeoniae Rubra 150 grams, the Radix Linderae 60 grams, Fructus Polygoni Orientalis 100 grams, Rhizoma Chuanxiong 100 grams, Radix Angelicae Sinensis 100 grams, Folium Citri tangerinae 100 grams, Herba Artemisiae Anomalae 100 grams.
Preparation technology:
(1) get the Flos Sophorae of recipe quantity, Radix Achyranthis Bidentatae, Artemisia lactiflora Wall., Fructus Crataegi, Herba Leonuri, Spica Prunellae, Radix Curcumae, Radix Paeoniae Rubra, the Radix Linderae, Fructus Polygoni Orientalis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Folium Citri tangerinae and Herba Artemisiae Anomalae, clean roguing, dry, pulverize;
(2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 8 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 3g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, packs and obtain oral liquid.
Embodiment 2
Crude drug prescription: 130 grams, Flos Sophorae, Radix Achyranthis Bidentatae 80 grams, Artemisia lactiflora Wall. 180 grams, Fructus Crataegi 180 grams, Herba Leonuri 120 grams, Spica Prunellae 120 grams, Radix Curcumae 120 grams, Radix Paeoniae Rubra 120 grams, the Radix Linderae 80 grams, Fructus Polygoni Orientalis 80 grams, Rhizoma Chuanxiong 80 grams, Radix Angelicae Sinensis 130 grams, Folium Citri tangerinae 130 grams, Herba Artemisiae Anomalae 130 grams.
Preparation technology:
(1) get the Flos Sophorae of recipe quantity, Radix Achyranthis Bidentatae, Artemisia lactiflora Wall., Fructus Crataegi, Herba Leonuri, Spica Prunellae, Radix Curcumae, Radix Paeoniae Rubra, the Radix Linderae, Fructus Polygoni Orientalis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Folium Citri tangerinae and Herba Artemisiae Anomalae, clean roguing, dry, pulverize;
(2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 10 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 3g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, packs and obtain oral liquid.
Embodiment 3
Crude drug prescription: 80 grams, Flos Sophorae, Radix Achyranthis Bidentatae 130 grams, Artemisia lactiflora Wall. 120 grams, Fructus Crataegi 120 grams, Herba Leonuri 180 grams, Spica Prunellae 180 grams, Radix Curcumae 80 grams, Radix Paeoniae Rubra 180 grams, the Radix Linderae 40 grams, Fructus Polygoni Orientalis 130 grams, Rhizoma Chuanxiong 130 grams, Radix Angelicae Sinensis 80 grams, Folium Citri tangerinae 80 grams, Herba Artemisiae Anomalae 80 grams.
Preparation technology:
(1) get the Flos Sophorae of recipe quantity, Radix Achyranthis Bidentatae, Artemisia lactiflora Wall., Fructus Crataegi, Herba Leonuri, Spica Prunellae, Radix Curcumae, Radix Paeoniae Rubra, the Radix Linderae, Fructus Polygoni Orientalis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Folium Citri tangerinae and Herba Artemisiae Anomalae, clean roguing, dry, pulverize;
(2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 10 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 3g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, adds correctives and packs and obtain oral liquid.
Embodiment 4 pharmaceutical composition of the present invention is to the Therapy study of cyclomastopathy patient
Female mammary gland cyclomastopathy patient 68 example, the oldest 51 years old, minimum 24 years old, maximum with 30 ~ 40 years old number, account for 59%.The course of disease is the longest 15 years, the shortest 3 months; Wherein 3 months ~ 1 year person 13 example.1 ~ 5 year person 37 example, 5 ~ 10 years person 18 examples.Diagnostic criteria: 1. patient has concomitant distending pain of the breast, premenstrual 7 ~ 10 days distending pain of the breast are obvious, through after symptom alleviate or disappear.Side or bilateral breast have multiple form irregular masses, in the form of sheets, streak or graininess, unclear with surrounding tissue boundary, with skin and deep tissue without adhesion, touch a tender spot, can promote.2. x-ray molybdenum palladium takes the photograph shade that sheet has edge blurry unclear or streak tissue passes through therebetween.Ultrasound diagnosis is uneven low echo area or echoless cyst.3. endocrine hormone measures if desired, and living tissue pathologic finding is diagnosed as cyclomastopathy.
Above 68 routine patients diagnosed are divided into following two groups at random: test group 34 example, matched group 34 example.Test group patient takes Chinese medicine oral liquid prepared by embodiment 1, sooner or later each 20ml; Matched group patient takes the RUKANG PIAN (specification 0.35g) that Ankang Chia Tai Pharmaceutical Co., Ltd. produces, each 3, oral meal, every day 3 times.Within 15 days, be a course for the treatment of, 1 ~ 3 course for the treatment of starts to evaluate curative effect.
Curative effect determinate standard is as follows:
Effective: lump disappears, mastalgia disappears, and drug withdrawal is not recurred for 3 months;
Effective: mass reduction more than 1/2, mastalgia disappears;
Take a turn for the better: lump maximum gauge reduces <1/2, and mastalgia alleviates, or mass reduction more than 1/2 mastalgia does not alleviate;
Invalid: lump do not reduce or increase on the contrary hardening or simple mastalgia alleviate and lump does not reduce.
Experimental result is see table 1, table 2.Two groups of Clinical efficacy comparisons: test group total effective rate 97.1%, matched group total effective rate 67.6%, test group clinical efficacy is better than matched group, in table 1.Two groups of total effectively cases compare the course for the treatment of, and its difference has statistical significance (P<0.05), and treatment group is evident as excellent.
Table 1 liang group patient clinical comparitive study (example)
| Group | Case load | Effective | Effectively | Take a turn for the better | Invalid | Total effective rate (%) |
| Matched group | 34 | 8 | 9 | 6 | 11 | 23（67.6） |
| Test group | 34 | 21 | 8 | 4 | 1 | 33（97.1） |
Table 2 liang effective patient procedure of group treatment compare
| Group | Number of cases | 1st course for the treatment of | 2nd course for the treatment of | 3rd course for the treatment of | Average course for the treatment of |
| Matched group | 23 | 5 | 11 | 7 | 2.09 |
| Test group | 33 | 26 | 5 | 2 | 1.27 |
Claims (3)
1. treat a pharmaceutical composition for cyclomastopathy, it is characterized in that: be prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 10 parts, Flos Sophorae, Radix Achyranthis Bidentatae 10 parts, Artemisia lactiflora Wall. 15 parts, Fructus Crataegi 15 parts, Herba Leonuri 15 parts, Spica Prunellae 15 parts, Radix Curcumae 10 parts, Radix Paeoniae Rubra 15 parts, the Radix Linderae 6 parts, Fructus Polygoni Orientalis 10 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Sinensis 10 parts, Folium Citri tangerinae 10 parts, Herba Artemisiae Anomalae 10 parts.
2. treat the pharmaceutical composition of cyclomastopathy according to claim 1, it is characterized in that: described pharmaceutical composition is oral formulations.
3. treat the pharmaceutical composition of cyclomastopathy according to claim 2, it is characterized in that: described oral formulations is oral liquid, granule, tablet or capsule.
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| 赵泽华,等.活血通络、理气散结法治疗乳腺小叶增生125例.《新中医》.2000,(第10期),44. * |
| 赵泽华;等.消癖汤治乳腺小叶增生症125例临床观察.《江西中医药》.2001,第32卷(第4期),30. * |
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