CN103690889B - A kind of Chinese medicine decoction for the treatment of gastric cancer - Google Patents
A kind of Chinese medicine decoction for the treatment of gastric cancer Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine decoction for the treatment of gastric cancer, belong to the field of Chinese medicines.It is made up of the crude drug of following weight: Olibanum 10 grams, Cortex Cinnamomi 10 grams, Spica Prunellae 15 grams, Lignum Aquilariae Resinatum 15 grams, Radix Ophiopogonis 15 grams, Rhizoma Curcumae 15 grams, Myrrha 15 grams, the Radix Astragali 15 grams, Radix Salviae Miltiorrhizae 15 grams, Fructus Ligustri Lucidi 15 grams, Fructus Schisandrae Chinensis 15 grams, Radix Angelicae Sinensis 15 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Rhizoma Corydalis 10 grams, Radix Rehmanniae 10 grams, Ganoderma 10 grams, Herba Hedyotidis Diffusae 10 grams, Rhizoma Polygonati Odorati 10 grams, Cortex Moutan 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams, Fructus Aurantii Immaturus 10 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, 5 grams, Moschus.The present invention has the effect of the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, and effectively control the transfer of primary lesion and the continuation diffusion of metastatic lesion, obviously alleviate gastric cancer clinical symptoms, treatment gastric cancer is evident in efficacy.
Description
Technical field
The present invention relates to a kind of Chinese medicine decoction for the treatment of gastric cancer, belong to technical field of Chinese medicines.
Background technology
Gastric cancer is the malignant tumor being derived from gastric epithelial cell, the first place of all kinds of tumor is occupied at its sickness rate of China, 170,000 people are about had to die from gastric cancer every year, almost close to 1/4 of whole mortality of malignant tumors number, the normal non-evident sympton of early gastric caacer, epigastrium feeling of repletion, sense of heaviness, anorexia, stomachache, nausea,vomiting,diarrhea can be engendered, become thin after progress that sb.'s illness took a turn for the worse, anemia, edema, heating etc., cancerous protuberance diffusion transfer can cause the transfer of ascites, hepatomegaly, jaundice and lung, brain, the heart, prostate, ovary, bone marrow etc. and occur corresponding symptom.The generation of gastric cancer is main is that food is relevant with dietary, also relevant with the factor such as heredity, body constitution.
Current doctor trained in Western medicine has operative treatment, radiotherapy, chemotherapy, immunization therapy etc. to gastric cancer conventional therapy, and above Therapeutic Method can only temporary transient symptom management, and can cause intraperitoneal pus infections or the extensive sequela such as adhesion after some operation in patients, patient's outcome is not good enough.Chinese traditional treatment gastric cancer occupies critical role in curing gastric cancer, but existing treatment by Chinese herbs effect is obvious not, takes effect slower, to such an extent as to a large amount of patient's received treatment of Chinese herbs, cancer metastasis diffusion on one side, substantially reduces the life time of patient.
Summary of the invention
Instant invention overcomes above-mentioned the deficiencies in the prior art, provide one and treat hypertensive Chinese medicine composition, can benefiting QI for activating blood circulation, nourishing yin and dispelling wind-evil, improve the adverse effect that primary disease brings patient.
Technical scheme of the present invention is: a kind of Chinese medicine decoction for the treatment of gastric cancer, it is characterized in that, be made up of the crude drug of following weight: Olibanum 10 grams, Cortex Cinnamomi 10 grams, Spica Prunellae 15 grams, Lignum Aquilariae Resinatum 15 grams, Radix Ophiopogonis 15 grams, Rhizoma Curcumae 15 grams, Myrrha 15 grams, the Radix Astragali 15 grams, Radix Salviae Miltiorrhizae 15 grams, Fructus Ligustri Lucidi 15 grams, Fructus Schisandrae Chinensis 15 grams, Radix Angelicae Sinensis 15 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Rhizoma Corydalis 10 grams, Radix Rehmanniae 10 grams, Ganoderma 10 grams, Herba Hedyotidis Diffusae 10 grams, Rhizoma Polygonati Odorati 10 grams, Cortex Moutan 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams, Fructus Aurantii Immaturus 10 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, 5 grams, Moschus.
Preparation and instructions of taking: be first soaked in water by above-mentioned raw materials 2 hours, decocting in water 30 minutes, pours out medicinal liquid; Add decocting in water again 30 minutes, pour out medicinal liquid; Twice medicinal liquid amalgamation rises, and cools completely, and respectively at half an hour before breakfast, within after supper two hours, takes.Serveing on 20 days is a course for the treatment of.
The pharmacological action of each Chinese medicine:
Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Cortex Cinnamomi: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Spica Prunellae: pungent, bitter, cold.Return liver, gallbladder meridian.Function with cure mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Lignum Aquilariae Resinatum: arduous, temperature.Enter kidney, spleen, stomach warp.Sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.Control QI rising in reverse order to pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.
Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.
Rhizoma Curcumae: toil, temperature.Enter liver, spleen channel.Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.
Myrrha: bitter, pungent is flat, nontoxic.Liver, spleen, the heart, kidney channel.Invigorate blood circulation analgesic therapy, detumescence and promoting granulation, cures mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, and skin infection does not close up after bursting for a long time.
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Function with cure mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Function with cure mainly: blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.
Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Nourishing the liver and kidney, improving eyesight black hair.For the hepatic and renal YIN deficiency, vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision, interior-heat is quenched one's thirst, osteopyrexia and fever.
Fructus Schisandrae Chinensis: sour, sweet, temperature.Lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.
Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Enter nutrient blood for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, mass in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection etc.
Rhizoma Chuanxiong: acrid in the mouth, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Rhizoma Corydalis: arduous, temperature.Enter liver, stomach warp.Invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Radix Rehmanniae: sweet, tepor.Return liver, kidney channel.Function with cure mainly: YIN nourishing of enriching blood, beneficial essence fills out marrow.For blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, dizzy, tinnitus, early whitening of beard and hair.
Ganoderma: sweet, flat.GUIXIN, lung, liver, kidney channel.There is the effect of antitumor and protecting liver and detoxication.
Herba Hedyotidis Diffusae: bitter sweet, cold.Nontoxic, enter heart channel, Liver Channel, spleen channel.Effect: heat-clearing and toxic substances removing; Dampness removing.Cure mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Be good at treatment kinds cancer.
Rhizoma Polygonati Odorati: sweet, is slightly cold.Attach to the lung and stomach meridians.Function with cure mainly: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.
Cortex Moutan: bitter in the mouth, pungent, cold nature, GUIXIN, liver, kidney channel.There is the merit of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.Modern study shows, Cortex Moutan has antiinflammatory, analgesia, the effect of stopping blooding, protecting the liver.
Pseudobulbus Cremastrae Seu Pleiones: sweet, micro-pungent, cold.Enter liver, spleen channel.Detumescence, eliminating stagnation, reduces phlegm, removing toxic substances.Control carbuncle furuncle to swell, scrofula, sore throat swells and ache, Serpentis, worm, mad dog wound.
Fructus Aurantii Immaturus: bitter, pungent, sour, is slightly cold.Return spleen, stomach warp.Function with cure mainly: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock of expectorant, the thoracic obstruction, blocked-up chest, visceroptosis.
Radix Arnebiae (Radix Lithospermi): sweet, salty, cold.GUIXIN, Liver Channel.Function with cure mainly: removing heat from blood, invigorate blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Moschus: pungent, temperature.Enter the heart, spleen, Liver Channel.Have one's ideas straightened out, ward off dirty, dredging collateral, dissipating blood stasis.Control apoplexy, syncope due to accumulation of phlegm, infantile convulsion, attacked by pestiferous factors is unhappy, trusted subordinate's sudden pain ， mass in the abdomen hypochondriac lump, traumatic injury, swollen ulcer drug.
The present invention is by after above drug regimen; drug effect has synergism, plays the effect of the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, effectively controls the transfer of primary lesion and the continuation diffusion of metastatic lesion; obvious alleviation gastric cancer clinical symptoms, the protection heart, Liver and kidney function.Be applied to the health that effectively can control patient self in the treatment of gastric cancer, treatment gastric cancer is evident in efficacy.
Below in conjunction with clinical data and model case, beneficial effect of the present invention is further illustrated.
One, clinical observation
1, clinical data: the outpatient service and inpatient totally 138 examples that are selected from December, 2011 to 2013 year March, wherein early gastric cancer 49 example.Age is 37-72 year, average 57.5 years old.
2, diagnostic criteria: be defined as foundation to the precancerous lesion of gastric cancer in " Chinese common cancer diagnosis and treatment specification " (the 4th gastric cancer) published according to China's nineteen ninety.
3, Therapeutic Method: take medicine of the present invention, soak by water, takes at twice sooner or later.It within 1 month, is 1 course for the treatment of.
4, efficacy assessment standard: the standard formulated according to Ministry of Public Health 1991 version " Chinese common cancer diagnosis and treatment specification ", is divided into:
1. complete incidence graph (CR), visual tumors disappears, and continues more than one month;
2. partial rcsponse (PR), the maximum orthogonal diameter product of two, tumor reduces more than 50%, and keeps more than 1 month;
3. stable (SD), the maximum orthogonal diameter product of two, tumor reduces less than 50%, increases and is no more than 25%, and continue more than one month;
4. ((PD), the maximum orthogonal diameter product of two, tumor increases above 25% in deterioration.
5, therapeutic outcome: complete incidence graph 103 example, partial rcsponse 14 example, stablizes 12 examples, worsens 9 examples.Effective percentage (CR+PR) is 84.8%, and coefficient of stabilization (CR+PR+SD) is 93.5%.There are 44 examples to cure (tumor all disappears, and follows up a case by regular visits to and does not recur for 1 year) in early stage 49 routine early hepatocarcinomas simultaneously.
6, toxic and side effects analysis
In the 138 routine patients observed, after taking Chinese medicine of the present invention, 2 routine laxativeness, occur that the probability of side reaction is only 1.45%, and dispose side reaction through suiting the medicine to the illness and disappear, all the other are without any side effects.
In sum, the present invention is used for the treatment of the Chinese medicine decoction of gastric cancer, through clinical trial, shows that it effectively can suppress stomach cancer development, improves patients symptomatic, sign, and without obvious toxic-side effects.
Two, model case
Case 1: poplar, female, 72 years old.Patients symptomatic is that stomach is vexed swollen, dyspepsia, sometimes Nausea and vomiting, is difficult to swallow during feed.Within one month, get off, obviously become thin, be diagnosed as Gerontal gastric cancer on inspection in hospital, tumor size differs, and the diameter 3.3cmx2.8cm of maximum tumor, because patient is advanced in age, is not suitable for operative treatment, accepts treatment by Chinese herbs of the present invention afterwards.After the course for the treatment of, stomach discomfort symptom obviously alleviates, and has a meal and also more and more can eat, sleep, and people is also spiritual.After patient the 5th the medicine course for the treatment of is eaten up, sensation health is solid as before disease, and body weight too increases.And serve on two the course for the treatment of medicine.Check through hospital: indices is normal, and tumor disappears comprehensively.Recurrence of following up a case by regular visits to that so far there are no.
Case 2: Zhang, man, 58 years old.Patient is old gastropathy throughout the year, and health is always weaker, and nearest flatulence stomachache is serious, anorexia of feeling sick.Think it has been gastrointestinal sick offender always, maintain by the stomach medicine eating a little anti-inflammatory analgetic.Pain increased the weight of afterwards, and health is obvious thin and weak.Gerontal gastric cancer is diagnosed as, the maximum tumor 3.5CMX3.3CM of stomach through hospital.Hospital considers that patient body situation is poor, and operation risk is very large.Started afterwards to take this patent Drug therapy.After the course for the treatment of, the phenomenons such as various pain symptom and nauseating anorexia are greatly improved; After three courses for the treatment of, the maximum tumor of stomach is contracted to 1.8CMX1.5CM by 3.5CMX3.3CM.This patient take six the course for the treatment of medicine later on inspection, stomach size tumor all disappears.Take altogether eight the course for the treatment of medicine, thoroughly cured.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine decoction for the treatment of gastric cancer, is made up of the crude drug of following weight: Olibanum 10 grams, Cortex Cinnamomi 10 grams, Spica Prunellae 15 grams, Lignum Aquilariae Resinatum 15 grams, Radix Ophiopogonis 15 grams, Rhizoma Curcumae 15 grams, Myrrha 15 grams, the Radix Astragali 15 grams, Radix Salviae Miltiorrhizae 15 grams, Fructus Ligustri Lucidi 15 grams, Fructus Schisandrae Chinensis 15 grams, Radix Angelicae Sinensis 15 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Rhizoma Corydalis 10 grams, Radix Rehmanniae 10 grams, Ganoderma 10 grams, Herba Hedyotidis Diffusae 10 grams, Rhizoma Polygonati Odorati 10 grams, Cortex Moutan 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams, Fructus Aurantii Immaturus 10 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, 5 grams, Moschus.
Preparation and instructions of taking: be first soaked in water by above-mentioned raw materials 2 hours, decocting in water 30 minutes, pours out medicinal liquid; Add decocting in water again 30 minutes, pour out medicinal liquid; Twice medicinal liquid amalgamation rises, and cools completely, and respectively at half an hour before breakfast, within after supper two hours, takes.Serveing on 20 days is a course for the treatment of.
Claims (1)
1. treat the Chinese medicine decoction of gastric cancer for one kind, it is characterized in that, be made up of the crude drug of following weight: Olibanum 10 grams, Cortex Cinnamomi 10 grams, Spica Prunellae 15 grams, Lignum Aquilariae Resinatum 15 grams, Radix Ophiopogonis 15 grams, Rhizoma Curcumae 15 grams, Myrrha 15 grams, the Radix Astragali 15 grams, Radix Salviae Miltiorrhizae 15 grams, Fructus Ligustri Lucidi 15 grams, Fructus Schisandrae Chinensis 15 grams, Radix Angelicae Sinensis 15 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Rhizoma Corydalis 10 grams, Radix Rehmanniae 10 grams, Ganoderma 10 grams, Herba Hedyotidis Diffusae 10 grams, Rhizoma Polygonati Odorati 10 grams, Cortex Moutan 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams, Fructus Aurantii Immaturus 10 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, 5 grams, Moschus.
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