CN103550695B - Medicament for treating breast cancer - Google Patents
Medicament for treating breast cancer Download PDFInfo
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- CN103550695B CN103550695B CN201310531412.3A CN201310531412A CN103550695B CN 103550695 B CN103550695 B CN 103550695B CN 201310531412 A CN201310531412 A CN 201310531412A CN 103550695 B CN103550695 B CN 103550695B
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Abstract
The invention discloses a medicament for treating breast cancer. The medicament comprises an orally-taken medicament and an externally-applied medicament, wherein the orally-taken medicament is prepared from the following material medicines: ginseng, prepared rehmannia root, lucid ganoderma, Chinese yam, schisandra chinensis, selfheal, oldenlandia diffusa, herba houttuyniae, brucea javanica, typhae pollen, cowherb seed, astragalus membranaceus, radix burpleuri, thunberg fritillary bulb, corydalis tuber, caulis spatholobi, caulis spatholobi, fruit of immature citron, edible tulip, curcuma zedoary, ligusticum wallichii, Chinese angelica, frankincense, herba leonuri, eclipta, citron peel and liquorice which are decocted in water; the externally-applied dug is prepared from the following material medicines: stiff silkworm, curcuma zedoary, ligusticum wallichii, Chinese angelica, thunberg fritillary bulb, platycodon grandiflorum, radix curcumae, turtle shell, achyranthes bidentata, caulis spatholobi, borneol, bee wax and sesame oil which are prepared into ointment. The effective rate for treating the breast cancer by the medicament disclosed by the invention is 100%.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of breast carcinoma, belong to technical field of Chinese medicines.
Background technology
Female mammary gland is made up of skin, fibrous tissue, corpus mamma and fat, and breast carcinoma is the malignant tumor occurring in mammary gland glandular epithelium tissue.Pathogenesis of breast carcinoma data displays in 2009 according to National Cancer Center and Ministry of Public Health prevention and control of diseases office are announced for 2012: national tumor registers the 1st that regional breast cancer incidence occupies female malignant, female mammary gland cancer morbidity (rough and careless) whole nation adds up to 42.55/10 ten thousand, city is 51.91/10 ten thousand, and rural area is 23.12/10 ten thousand.
The primary treatments of current breast carcinoma is that art is cut in operation, brings huge injury to patient's body and mind.
Summary of the invention
Instant invention overcomes above-mentioned the deficiencies in the prior art, provide a kind of medicine for the treatment of breast carcinoma.This medicine adopts Chinese herbal medicine to be raw material, does not substantially have toxic and side effects, and effectively can treat breast carcinoma.
Technical scheme of the present invention is: a kind of medicine for the treatment of breast carcinoma, is characterized in that, comprises endo-medicine and liniment,
Described endo-medicine is made up of the crude drug of following weight parts: Radix Ginseng 10, Radix Rehmanniae Preparata 15, Ganoderma 10, Rhizoma Dioscoreae 10, Fructus Schisandrae Chinensis 15, Spica Prunellae 10, Herba Hedyotidis Diffusae 15, Herba Houttuyniae 12, Fructus Bruceae 12, Pollen Typhae 10, Semen Vaccariae 10, the Radix Astragali 10, Radix Bupleuri 20, Bulbus Fritillariae Thunbergii 15, Rhizoma Corydalis 10, Caulis Spatholobi 15, Fructus Aurantii Immaturus 8, Pseudobulbus Cremastrae Seu Pleiones 15, Rhizoma Curcumae 10, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 20, Olibanum 15, Herba Leonuri 10, Herba Ecliptae 10, Pericarpium Citri 15 and Radix Glycyrrhizae 5, soak by water;
Described liniment is made up of the crude drug of following weight parts: Bombyx Batryticatus 10, Rhizoma Curcumae 15, Rhizoma Chuanxiong 10, Radix Angelicae Sinensis 15, Bulbus Fritillariae Thunbergii 15, Radix Platycodonis 10, Radix Curcumae 10, Carapax Trionycis 15, Radix Achyranthis Bidentatae 8, Caulis Spatholobi 8, Borneolum Syntheticum 10, Cera Flava 10-20 and Oleum Sesami 30-60, makes ointment.
Preparation method: endo-medicine soak by water, takes at twice sooner or later; External used medicine: Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Bulbus Fritillariae Thunbergii, Radix Platycodonis, Radix Curcumae, Carapax Trionycis, Radix Achyranthis Bidentatae, Caulis Spatholobi and Borneolum Syntheticum are clayed into power, excessively 200 mesh sieves, then add Cera Flava and Oleum Sesami makes ointment use.It within 1 month, is 1 course for the treatment of.
The pharmacological action of each Chinese medicine:
Radix Ginseng: sweet, micro-hardship is flat.Return spleen, lung, heart channel.Function with cure mainly: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function with cure mainly: YIN nourishing of enriching blood, beneficial essence fills out marrow.For blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, dizzy, tinnitus, early whitening of beard and hair.
Ganoderma: sweet, flat.GUIXIN, lung, liver, kidney channel.There is the effect of antitumor and protecting liver and detoxication.
Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.
Fructus Schisandrae Chinensis: sour, sweet, temperature.Lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.
Spica Prunellae: pungent, bitter, cold.Return liver, gallbladder meridian.Function with cure mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Herba Hedyotidis Diffusae: bitter sweet, cold.Nontoxic, enter heart channel, Liver Channel, spleen channel.Effect: heat-clearing and toxic substances removing; Dampness removing.Cure mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Be good at treatment kinds cancer.
Herba Houttuyniae: heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.Cure mainly: the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies etc.
Fructus Bruceae: bitter, cold; Slightly poisonous.Return large intestine, Liver Channel.Function with cure mainly: heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, dysentery relieving, corrosion wart.For dysentery, malaria; External treatment wart, clavus.
Pollen Typhae: sweet, flat.Return liver, pericardium channel.Function with cure mainly: stop blooding, blood stasis dispelling, treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Semen Vaccariae: bitter is flat.Return liver, stomach warp.Function with cure mainly: promoting blood circulation to restore menstrual flow, stimulating milk secretion subside a swelling.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Function with cure mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Bupleuri: reconciling superficies and interior, soothing the liver, yang invigorating.Function with cure mainly: for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official prolapsus, proctoptosis.
Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, return lung, heart channel.There is preventing phlegm from forming and stopping coughing, the merit of heat clearing away eliminating stagnation.Modern study shows, Bulbus Fritillariae Thunbergii has expansion smooth muscle, increase blood flow, analgesic effect.
Rhizoma Corydalis: pungent, bitter, temperature.Return liver, spleen channel.Function with cure mainly: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Caulis Spatholobi: bitter in the mouth, micro-sweet, warm in nature, returns Liver Channel.Have that promoting the circulation of blood is enriched blood, the merit of relaxing muscles and tendons and activating QI and blood in the collateral.Modern study shows, Caulis Spatholobi is improved hemopoietic system, blood vessel dilating, increase tissue blood fluid, immunity moderation, antithrombotic, antineoplastic action.
Fructus Aurantii Immaturus: bitter, pungent, sour, is slightly cold.Return spleen, stomach warp.Function with cure mainly: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock of expectorant, the thoracic obstruction, blocked-up chest, visceroptosis.
Pseudobulbus Cremastrae Seu Pleiones: sweet, micro-pungent, cold.Enter liver, spleen channel.Detumescence, eliminating stagnation, reduces phlegm, removing toxic substances.Control carbuncle furuncle to swell, scrofula, sore throat swells and ache, Serpentis, worm, mad dog wound.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel, there is effect of eliminating stagnation, removing blood stasis, promoting the circulation of QI to relieve pain, also have protect the liver, antiinflammatory, antitumor action.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.
Olibanum: property acrid, bitter, warm.Enter the heart, liver, spleen channel.Invigorate blood circulation, circulation of qi promoting, pain relieving.Herba Leonuri: bitter, pungent, is slightly cold.Return liver, pericardium, urinary bladder channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.
Herba Ecliptae: sweet, sour, cold.Return kidney, Liver Channel.Function with cure mainly: nourishing the liver and kidney, cooling blood for hemostasis.For the hepatic and renal YIN deficiency, odontoseisis, early whitening of beard and hair, dizzy ear toot, soreness of the waist and knees, YinXuXueRe haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Pericarpium Citri: pungent, bitter, sour, temperature.Enter liver, lung, spleen channel.Function with cure mainly: regulate the flow of vital energy, Shu Yu, expectorant, sharp diaphragm.Treat for stomachache distension, and cough due to fluid-retention gas is moulded, the few food of the sound of vomiting of vomitting.
Radix Glycyrrhizae: coordinating the actions of various ingredients in a prescription.
Bombyx Batryticatus: expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, submandibular lymph nodes is scorching, facial paralysis, skin pruritus.
Radix Platycodonis: bitter, pungent is flat.Return lung meridian.Function with cure mainly: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Radix Curcumae: pungent, bitter, cold.Return liver, the heart, lung meridian.Function with cure mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is put down, and returns liver, kidney channel.There is the merit of blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.Modern study shows, Radix Achyranthis Bidentatae is improved microcirculation, immunity moderation, antiinflammatory, detumescence, analgesic effect.
Carapax Trionycis: salty, is slightly cold.Return liver, kidney channel.Nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming, hard masses softening and resolving.For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, hyperactivity of YANG due to deficiency of YIN, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency.
Borneolum Syntheticum: pungent, bitter, is slightly cold.GUIXIN, spleen, lung meridian.Function cures mainly: refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Faint for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Cera Flava: sweet, tepor.Function cures mainly: astringent therapy, sore, granulation promoting, pain relieving, conditioning.Outer for ulcer being unable to heal, ecthyma is rotten to the corn.
Oral medicine of the present invention is based on antitumor and YIN nourishing training unit, and soothing liver-QI for relieving depression, activating blood circulation to dissipate blood stasis and dissipating phlegm and resolving masses are auxiliary; Application compress are with activating blood circulation to dissipate blood stasis, and dissipating phlegm and resolving masses, anti-inflammatory analgesic is main, the two combined effect, treating both the principal and secondary aspects of a disease, jointly reaches the effect for the treatment of breast carcinoma.
Its beneficial effect is further illustrated below in conjunction with clinical data and model case:
One, clinical data:
1, clinical data
The outpatient service choosing 2009.2-2011.2 and be in hospital primary breast cancer patients 235 example, age 30-58 year, average 45.2 years old;
2, diagnostic criteria: be all diagnosed as breast carcinoma through cytology and pathology section;
3, Therapeutic Method: adopt of the present invention for oral administration+liniment, within 1 month, be 1 course for the treatment of;
4, efficacy assessment standard: complete incidence graph (CR): all visible focuses disappear completely, at least maintain more than 4 weeks; Partial rcsponse (PR): the product in longest diameter of tumor and maximum perpendicular footpath reduces more than 50%, is in progress without other focuses, occurs without any new focus; Stable disease unchanged (SD): the product minimizing in longest diameter of tumor and maximum perpendicular footpath is less than 50%, or increase is no more than 25%, occurs without any new focus; Progress (PD): the product in longest diameter of tumor and maximum perpendicular footpath is greater than 25%; CR+PR is total effective rate.
5, therapeutic outcome: CR 123 example, PR112 example, SD and PD is 0.Rate is always had to be 100%.
Two, model case
Case 1: Lee, female, 42 years old.Patient has breast to have lump, pain, axillary gland enlargement, and weak with health, inappetence, and the symptoms such as poor sleeping quality, go to see a doctor.Breast carcinoma is diagnosed as through cytology and pathology section through hospital.Adopt of the present invention for oral administration+liniment treats.After taking 1 course for the treatment of, lump in breast diminishes, pain relief, and appetite takes a turn for the better, after continuing to take 4 courses for the treatment of, and lymph node and mammary swelling transference cure.Follow up a case by regular visits to after 1 year without recurrence.
Case 2: Jiang, female, 37 years old.Patient suffers from breast carcinoma in JIUYUE, 2010 through hospital diagnosis.Because patient body weakness is not suitable for operative treatment, adopt Chinese medicine expectant treatment.Adopt of the present invention for oral administration+liniment treats.After taking 2 courses for the treatment of, lump progressively diminishes, and after two courses for the treatment of of continuing to take medicine, lump disappears completely.Recurrence that so far there are no.
Detailed description of the invention
Embodiment 1
Endo-medicine formula (unit: g): Radix Ginseng 10, Radix Rehmanniae Preparata 15, Ganoderma 10, Rhizoma Dioscoreae 10, Fructus Schisandrae Chinensis 15, Spica Prunellae 10, Herba Hedyotidis Diffusae 15, Herba Houttuyniae 12, Fructus Bruceae 12, Pollen Typhae 10, Semen Vaccariae 10, the Radix Astragali 10, Radix Bupleuri 20, Bulbus Fritillariae Thunbergii 15, Rhizoma Corydalis 10, Caulis Spatholobi 15, Fructus Aurantii Immaturus 8, Pseudobulbus Cremastrae Seu Pleiones 15, Rhizoma Curcumae 10, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 20, Olibanum 15, Herba Leonuri 10, Herba Ecliptae 10, Pericarpium Citri 15 and Radix Glycyrrhizae 5, soak by water;
Preparation and instructions of taking: soak by water, take at twice sooner or later.
Extenral application medicine formulation (unit: g): Bombyx Batryticatus 10, Rhizoma Curcumae 15, Rhizoma Chuanxiong 10, Radix Angelicae Sinensis 15, Bulbus Fritillariae Thunbergii 15, Radix Platycodonis 10, Radix Curcumae 10, Carapax Trionycis 15, Radix Achyranthis Bidentatae 8, Caulis Spatholobi 8, Borneolum Syntheticum 10, Cera Flava 15 and Oleum Sesami 50.
Method of preparation and use: Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Bulbus Fritillariae Thunbergii, Radix Platycodonis, Radix Curcumae, Carapax Trionycis, Radix Achyranthis Bidentatae, Caulis Spatholobi and Borneolum Syntheticum are clayed into power, excessively 200 mesh sieves, then add Cera Flava and Oleum Sesami makes ointment use.
Using method: the two with the use of, within 1 month, be 1 course for the treatment of.
Claims (1)
1. treat a medicine for breast carcinoma, it is characterized in that, be made up of endo-medicine and liniment,
Described endo-medicine is made up of the crude drug of following weight parts: Radix Ginseng 10, Radix Rehmanniae Preparata 15, Ganoderma 10, Rhizoma Dioscoreae 10, Fructus Schisandrae Chinensis 15, Spica Prunellae 10, Herba Hedyotidis Diffusae 15, Herba Houttuyniae 12, Fructus Bruceae 12, Pollen Typhae 10, Semen Vaccariae 10, the Radix Astragali 10, Radix Bupleuri 20, Bulbus Fritillariae Thunbergii 15, Rhizoma Corydalis 10, Caulis Spatholobi 15, Fructus Aurantii Immaturus 8, Pseudobulbus Cremastrae Seu Pleiones 15, Rhizoma Curcumae 10, Rhizoma Chuanxiong 12, Radix Angelicae Sinensis 20, Olibanum 15, Herba Leonuri 10, Herba Ecliptae 10, Pericarpium Citri 15 and Radix Glycyrrhizae 5, soak by water;
Described liniment is made up of the crude drug of following weight parts: Bombyx Batryticatus 10, Rhizoma Curcumae 15, Rhizoma Chuanxiong 10, Radix Angelicae Sinensis 15, Bulbus Fritillariae Thunbergii 15, Radix Platycodonis 10, Radix Curcumae 10, Carapax Trionycis 15, Radix Achyranthis Bidentatae 8, Caulis Spatholobi 8, Borneolum Syntheticum 10, Cera Flava 10-20 and Oleum Sesami 30-60, makes ointment.
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| CN104491165A (en) * | 2014-12-30 | 2015-04-08 | 潘振奎 | Formula and preparation method of traditional Chinese medicine for treating breast cancer |
| CN104721400A (en) * | 2015-04-10 | 2015-06-24 | 李孟平 | Traditional Chinese medicine composition for treating liver qi stagnation type breast cancer |
| CN104825914A (en) * | 2015-04-16 | 2015-08-12 | 山东省肿瘤医院 | Traditional Chinese medicinal preparation for assisted treatment of breast cancer |
| CN105663768A (en) * | 2016-02-02 | 2016-06-15 | 吕伟 | Medicine for treating breast cancer and preparation method of medicine |
| CN105999123A (en) * | 2016-07-29 | 2016-10-12 | 王锦生 | Pure traditional Chinese medicine prescription for treating breast cancer and preparation method thereof |
| CN108969731A (en) * | 2018-10-12 | 2018-12-11 | 广西壮族自治区药用植物园 | The preparation method for treating the Caulis Spatholobi ointment of breast cancer |
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| CN101085308A (en) * | 2007-06-29 | 2007-12-12 | 杨文琳 | Oral administration traditional Chinese medicine decoction for treating mammary cancer |
| CN101085301A (en) * | 2007-06-29 | 2007-12-12 | 胡玉翠 | Oral administration traditional Chinese medicine composition for treating mammary cancer |
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| CN101085308A (en) * | 2007-06-29 | 2007-12-12 | 杨文琳 | Oral administration traditional Chinese medicine decoction for treating mammary cancer |
| CN101085301A (en) * | 2007-06-29 | 2007-12-12 | 胡玉翠 | Oral administration traditional Chinese medicine composition for treating mammary cancer |
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