CN105727317A - Gastrointestinal contrast agent and application thereof - Google Patents

Gastrointestinal contrast agent and application thereof Download PDF

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CN105727317A
CN105727317A CN201610242342.3A CN201610242342A CN105727317A CN 105727317 A CN105727317 A CN 105727317A CN 201610242342 A CN201610242342 A CN 201610242342A CN 105727317 A CN105727317 A CN 105727317A
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contrast agent
gastrointestinal
radix
stomach
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张艳娟
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention provides a gastrointestinal contrast agent and application thereof.The gastrointestinal contrast agent comprises, by weight, 5-15 parts of cortex magnoliae officinalis, 5-10 parts of rhizoma cyperi, 6-15 parts of fructus aurantii, 15-25 parts of concha arcae, 10-20 parts of limonitum, 5-15 parts of costus roots, 8-15 parts of poria, 5-10 parts of semen coicis, 5-15 parts of pericarpium citri reticulatae, 10-20 parts of radix codonopsis and 5-10 parts of rhizoma atractylodis macrocephalae.The invention further discloses a preparation method of the gastrointestinal contrast agent.The method includes the steps that water is added to traditional Chinese medicine weighed according to the weight ratio to soak the medicine for 10-12 hours, effective ingredients are subjected to decoction and extraction, and granules are prepared after the effective ingredients are concentrated.The medicine can be further used as medicine for treating gastrointestinal disease, in the medicine components of the contrast agent, qi-regulating medicine serves as the main component which is in compatibility with medicine capable of tonifying the spleen and the stomach, dispelling phlegm and eliminating dampness, smell in the stomach is removed, external interference is eliminated, and the functions of tonifying the stomach and the spleen and treating stomach disease are achieved.The gastrointestinal contrast agent can improve image definition, is convenient to take, flexible, simple, convenient and free of pain and is widely applied and popularized as the preferred essential main checking means for stomach lesion diagnosis.

Description

A kind of gastrointestinal contrast agent and application thereof
Technical field
The invention belongs to contrast agent field, especially relate to a kind of gastrointestinal contrast agent and application thereof.
Background technology
Contrast agent (also known as contrast medium, contrastmedia) is to inject (or taking) to human body group for strengthening Imaging Study effect Knit or the chemicals of organ.The density of these goods is higher or lower than surrounding tissue, the contrast of formation some apparatus display figure Picture.Operand as conventional in x-ray observation, barium sulfate etc..
Through acute and chronic toxicity test, genetic toxicology, clinical practice application attestation, (this data is reflected from Chinese medicine gastrointestinal image agent Determine material), Chinese medicine gastrointestinal image agent meets the requirement of " ideal contrast media ", the most 1. avirulence；2. comparative is strong, development Clear；The most easy to use, affordable；4. it is prone to swallow and drain；5. physical and chemical performance is stable, and storage for a long time is never degenerated.In Medicine contrast agent image not only conforms to the requirement of x-ray double contrast gastrointestinal study's picture quality, and can clearly sketch the contours of stomach The contour line of intestinal wall, easily finds that the gastrointestinal tract profile that pathological changes causes changes, can clearly show duplicature, whether observe mucosa Have that increasing is thick, disorderly, get together, such as forms such as shaft-like or interruptions.Owing to Chinese medicine contrast agent density value is less than barium sulfate, full During picture, can recognize be hidden in merely full as in gastric mucosa pleat, add image level, can clearly show alcove, Target is levied, ring carry levy, the x-ray sign such as thumprinting.
Chinese medicine composition the most extensively gets up as the application of contrast agent at present, such as Chinese invention patent application number: 01128137.5 Provide a kind of for color gastrointestinal ultrasonic contrast medium, be made up of Margarita 1 part, Concha Haliotidis 1 part, Endoconcha Sepiae 1 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1 part, Can clarify a diagnosis human body gastritis, gastric ulcer, gastric cancer, gastroptosis, prolapse of gastric mucosa, duodenal bulbar inflammation, duodenal bulb The disease such as cancerous protuberance at portion's ulcer, phase morning, noon and afternoon gastrointestinal tumor, esophagus upper-lower section and cardia.
Chinese invention patent application number 200810238127.1 discloses Chinese medicine contrast agent of a kind of B ultrasonic use and preparation method thereof, its Contrast agent includes the various raw materials of following portions by weight ratio: Concha Haliotidis 10～20 parts, Concha Erosariae seu Cypraeae 10～20 parts, Massa Medicata Fermentata 10～20 parts, Radix Codonopsis 10～20 parts, the Rhizoma Atractylodis Macrocephalae 10～20 parts, Poria 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Patriniae 10～20 parts, the Radix Linderae 10～ 20 parts, Radix Aucklandiae (Radix Vladimiriae) 10～20 parts.
Chinese invention patent application number 201210364551.7 has supplied a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic and preparation method thereof, Chinese medicine includes following raw medicinal material: Fructus Foeniculi, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, the Radix Linderae, Endoconcha Sepiae, Pericarpium Citri Reticulatae Viride, Massa Medicata Fermentata, Fructus Hordei Germinatus, trifoliate orange Reality, Radix Et Rhizoma Rhei, Natrii Sulfas, Cortex Magnoliae Officinalis, Radix Aucklandiae (Radix Vladimiriae), Fructus Amomi, Herba Pogostemonis, Fructus Citri Sarcodactylis, Fructus Crataegi, Semen Raphani, Concha Arcae (calcined), Fructus Evodiae, The Rhizoma Pinelliae, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Nardostachyos and Bulbus Fritillariae Thunbergii.
Chinese patent CN201510487240 gastrointestinal tract contrast medium, it is disclosed that barium sulfate 50～70 parts, Chinese medicine extract 25～35 parts, Mel 50～80 parts and water 300～500 parts；Wherein Chinese medicine extract is formulated by following raw material of Chinese medicine: tiger Sting 20～30 parts, Radix Berchemiae Giraldianae 20～30 parts, soil Radix Adenophorae (Radix Glehniae) 20～30 parts, white residual flower 10～15 parts, the Rhizoma Pinelliae 10～15 parts, Monas cuspurpureus Went 10～ 15 parts, Herba Asplenii Incisi 10～15 parts, Radix Rehmanniae 10～15 parts, the Fructus Sophorae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, the Radix Astragali 5～10 parts, bavin 5～10 parts recklessly, the present invention have gastrointestinal peristalsis inhibition too fast, auxiliary barium meal swallow, nourish gastrointestinal tract and suppression gastrorrhagia advantage.
In recent years, along with the development of Chinese medicine, also there are some to use Chinese medicine to do contrast agent clinically, achieve good effect Really, but the medicine that can carry out clinically promoting is the most fewer, therefore finds a kind of image definition high, diagnoses focus Accurately, and clinically the contrast agent being easy to use and promote is that image aspect is explored always.
Summary of the invention
The shortcoming of barium meal contrast medium when it is an object of the invention to overcome the intestines and stomach radiological survey X described in background technology, it is provided that Yi Zhongyong Pharmaceutical preparation and application thereof in gastrointestinal series.
Concrete technical scheme is, a kind of gastrointestinal contrast agent, according to weight fraction ratio, including: Cortex Magnoliae Officinalis 5-15 part, Rhizoma Cyperi 5-10 part, Fructus Aurantii 6-15 part, Concha Arcae 15-25 part, Limonitum 10-20 part, Radix Aucklandiae (Radix Vladimiriae) 5-15 part, Poria 8-15 part, Semen Coicis 5-10 part, Pericarpium Citri Reticulatae 5-15 part, Radix Codonopsis 10-20 part, Rhizoma Atractylodis Macrocephalae 5-10 part.
For obtaining more preferable implementation result, a kind of gastrointestinal contrast agent, according to weight fraction ratio, including: Cortex Magnoliae Officinalis 10 parts, fragrant Attached 8 parts, Fructus Aurantii 10 parts, Concha Arcae 20 parts, Limonitum 15 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, 12 parts of Poria, Semen Coicis 8 parts, Pericarpium Citri Reticulatae 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 8 parts.
For obtaining more preferable implementation result, a kind of gastrointestinal contrast agent, according to weight fraction ratio, including: Cortex Magnoliae Officinalis 6 parts, Rhizoma Cyperi 5 parts, Fructus Aurantii 6 parts, Concha Arcae 16 parts, Limonitum 12 parts, Radix Aucklandiae (Radix Vladimiriae) 5 parts, 8 parts of Poria, Semen Coicis 5 parts, Pericarpium Citri Reticulatae 6 parts, Radix Codonopsis 10 parts, the Rhizoma Atractylodis Macrocephalae 6 parts.
For obtaining more preferable implementation result, the contrast agent of a kind of gastrointestinal series, according to weight fraction ratio, including: Cortex Magnoliae Officinalis 15 Part, Rhizoma Cyperi 10 parts, Fructus Aurantii 15 parts, Concha Arcae 25 parts, Limonitum 10 parts, Radix Aucklandiae (Radix Vladimiriae) 15 parts, 15 parts of Poria, the heart of a lotus seed Semen Coicis 10 parts, Pericarpium Citri Reticulatae 15 parts, Radix Codonopsis 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.
The present invention also provides for a kind of method prepared and use above contrast agent:
According to Cortex Magnoliae Officinalis 5-15 part, Rhizoma Cyperi 5-10 part, Fructus Aurantii 6-15 part, Concha Arcae 15-25 part, Limonitum 10-20 part, extensively wood Fragrant 5-15 part, Poria 8-15 part, Semen Coicis 5-10 part, Pericarpium Citri Reticulatae 5-15 part, Radix Codonopsis 10-20 part, the ratio of Rhizoma Atractylodis Macrocephalae 5-10 part, The present invention is to above prescription through conscientious research, and according to the reasonability of middle medical drugs, invention proposes medicine system of the present invention The preparation method of agent, concretely comprises the following steps:
1) Cortex Magnoliae Officinalis, Rhizoma Cyperi, Fructus Aurantii, Concha Arcae, Limonitum, Radix Aucklandiae (Radix Vladimiriae), Poria, Semen Coicis, Pericarpium Citri Reticulatae, Radix Codonopsis and the Rhizoma Atractylodis Macrocephalae are dried, Pulverize 80～120 sieves and soak 10-12 hour；
2) by step 1) in pulverize after Chinese medicine powder by the weight mix homogeneously of prescription of the present invention；Decocting effective component extracting, Pelletize, vacuum drying, granulate, obtain granule of the present invention.
The preparation method vacuum drying temperature of the present invention is 40-50 DEG C, and this granule is oral when contrast agent, according to The dosage of 200g/100ml is taken after mixing it with water, and water temperature is 40-80 degree.
The present invention also provides for a kind of prevention and the medicine for the treatment of gastrointestinal disease, includes according to weight fraction ratio: Cortex Magnoliae Officinalis 5-15 part, Rhizoma Cyperi 5-10 part, Fructus Aurantii 6-15 part, Concha Arcae 15-25 part, Limonitum 10-20 part, Radix Aucklandiae (Radix Vladimiriae) 5-15 part, Poria 8-15 Part, Semen Coicis 5-10 part, Pericarpium Citri Reticulatae 5-15 part, Radix Codonopsis 10-20 part, Rhizoma Atractylodis Macrocephalae 5-10 part.Concrete steps method is with above-mentioned system Preparation Method.
A kind of prevention and the medicine for the treatment of gastrointestinal disease, it is preferable that include according to weight fraction ratio: Cortex Magnoliae Officinalis 10 parts, Rhizoma Cyperi 8 Part, Fructus Aurantii 10 parts, Concha Arcae 20 parts, Limonitum 15 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, 12 parts of Poria, Semen Coicis 8 parts, old Skin 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 8 parts.Concrete steps method is with above-mentioned preparation method.
The present invention also protects a kind of pharmaceutical preparation application in preparing gastrointestinal color ultrasound contrast agent.
Application in pharmaceutical preparation of the present invention preparation prevention and treatment gastrointestinal disease medicine, described gastrointestinal disease is stomach Ulcer, acute gastritis, chronic gastritis or duodenal ulcer.
The function of each taste Chinese crude drug used in the pharmaceutical preparation of the treatment of the present invention is as follows:
Cortex Magnoliae Officinalis: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach, lung, large intestine channel.
Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed heavily Cough.
Rhizoma Cyperi: bitter in the mouth, property is put down.
Gui Jing: return liver, spleen, tri-jiao channel.
Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass Vexed, colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Fructus Aurantii: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach warp.
Function cures mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Coerce the stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion for breast, stop in phlegm retention；Under stomach Hanging down, proctoptosis, sub-official prolapses.
Concha Arcae: salty in the mouth, property is put down.
Gui Jing: return lung, stomach, Liver Channel.
Function with cure mainly: expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, thickness difficulty is coughed up, goiter, scrofula, Abdominal mass mass in the abdomen, pantothenic acid of having a stomachache.
Limonitum: sweet puckery；Flat；Cold；Salty.
Gui Jing: spleen channel；Stomach warp；Large intestine channel.
Function cures mainly: astringing intestine to stop diarrhea；Hemostasis；Leukorrhagia stopping.Cure mainly chronic diarrhea；Chronic dysentery；Married woman's bleeding not during menses；Have blood in stool.
Radix Aucklandiae (Radix Vladimiriae): sweet in the mouth, warm in nature.
Gui Jing: return spleen, stomach, large intestine, gallbladder meridian.
Function cures mainly: can lead to manner, easing stomach-QI, row irritability, dissipates stagnant gas, broken stagnation of QI, and the most distressed, by cold air, peace cholera is vomited and diarrhoea, Vomiting regurgitation of food from the stomach, except painful abdominal mass addiction disease block, umbilicus abdominal distention and pain, antiabortive scattered poison, controls dysentery required, and wards off pestilential pathogen miasma.
Poria: sweet in the mouth, property are flat.
Gui Jing: GUIXIN, lung, spleen, kidney channel.
Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, and for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, the mind Uneasiness, palpitation with fear insomnia.
Semen Coicis: sweet in the mouth, cool in nature.
Gui Jing: return spleen, stomach, lung meridian.
Function cures mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, and row is dense in heat clearing away.For edema, tinea pedis, dysuria, arthralgia chiefly caused by damp pathogen contracture, spleen Diarrhea due to deficiency rushes down, lung abscess, acute appendicitis；Verruca plana.
Pericarpium Citri Reticulatae: bitter in the mouth, warm in nature.
Gui Jing: return lung, spleen channel.
Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Radix Codonopsis: sweet in the mouth, property is put down.
Gui Jing: return spleen, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat Quench one's thirst.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach warp.
Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, water Swollen, spontaneous perspiration, frequent fetal movement.
The effects such as the Cortex Magnoliae Officinalis energy removing dampness intestinal stasis relieving in the present invention, circulation of qi promoting are relievingd asthma, relieving dyspepsia expectorant, wind dispelling analgesia, Cortex Magnoliae Officinalis also has regulation intestinal Function, antiulcer, suppression maincenter, blood pressure lowering and the effect of facilitating digestion；Rhizoma Cyperi can be regulated the flow of vital energy resolving depression, pain relieving regulating menstruation, For treating incoordination between the liver and stomach, depression of QI, chest and abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses etc..Fructus Aurantii Circulation of qi promoting is had to disappear painful abdominal mass, effect that removing food stagnancy reduces phlegm.For conventional qi-activating drug, it is mainly used to treat depression and stagnation of QI, internal flatulence, Distending pain, feeling of fullness, internal phlegm retention, food stagnation can be treated.Concha Arcae: expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for stupid Accumulation of phlegm is tied, and thickness difficulty is coughed up, goiter, scrofula, abdominal mass mass in the abdomen, and pantothenic acid of having a stomachache, treat for stomachache acid regurgitation water, eructation, the most then haematemesis person Respond well with digestive tract ulcer.Limonitum: astringing intestine to stop diarrhea；Hemostasis；Leukorrhagia stopping.Cure mainly chronic diarrhea；Chronic dysentery；Married woman's bleeding not during menses； Have blood in stool.Radix Aucklandiae (Radix Vladimiriae), the stagnant use of preferably giving birth to of circulation of qi promoting, antidiarrheal dysentery preferably simmers use.Poria, promoting diuresis to eliminate damp pathogen, and mild in medicine property and, diuretic and not Hinder healthy energy.Semen Coicis, spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, muscle arteries and veins contracture, joint stuffiness, edema, Tinea pedis, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.Pericarpium Citri Reticulatae, temperature；Pungent, bitter；Return spleen, lung meridian, there is invigorating the spleen and regulating the stomach, Promoting the circulation of QI to alleviate the stagnation in middle-JIAO, effect of lowering the adverse-rising QI and eliminating phlegm.Curing mainly stagnation of QI in spleen and stomach, gastral cavity abdomen covers with, nausea and vomiting, inappetence, cough with copious phlegm, Chest and diaphragm is full vexed, globus hystericus.Radix Codonopsis is sweet, flat.Return spleen, lung meridian, QI invigorating, promote the production of body fluid, nourish blood, there is Gastrointestinal motility adjustment, Antiulcer, gastric acid secretion inhibiting, reduces the effects such as pepsin activity.The Rhizoma Atractylodis Macrocephalae, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, Antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Compared with prior art, in the medicament composing prescription of the contrast agent of the present invention, with QI regulating medicine as main formula, compatibility invigorating the spleen and regulating the stomach, The medicine of dispelling phlegm and eliminating dampness, dispels the gas of gastric, gets rid of extraneous interference, has stomach invigorating and the effect of spleen treatment gastropathy concurrently.This The stomach contrast agent of invention uses as contrast agent, easy to use, good in taste, and the image of formation is clear, and the strong echo of point-like is anti- Penetrating, coat of the stomach clear layer is visible, and gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, stomach are big Curved grade images substantially, can improve image definition, and the accuracy of diagnosis of gastrosis, because of taking convenience, flexible and convenient, no pain Hurtless measure, in fact can the extensively application popularization as the first-selected indispensable main detection methods of gastropathy diagnosis.
Detailed description of the invention
It is obvious to a person skilled in the art that the details of invention one exemplary embodiment, and without departing substantially from this In the case of bright spirit or essential attributes, it is possible to realize the present invention in other specific forms.Which point therefore, no matter from come Seeing, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by claims not It is that described above limits, it is intended that all changes fallen in the implication of equivalency and scope of claim are included at this In invention.
Embodiment 1: a kind of gastrointestinal contrast agent, according to weight fraction ratio, including:
Cortex Magnoliae Officinalis 10 parts, Rhizoma Cyperi 8 parts, Fructus Aurantii 10 parts, Concha Arcae 20 parts, Limonitum 15 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, Fu Siberian cocklebur 12 parts, Semen Coicis 8 parts, Pericarpium Citri Reticulatae 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 8 parts.
Preparation method is:
1) Cortex Magnoliae Officinalis, Rhizoma Cyperi, Fructus Aurantii, Radix Aucklandiae (Radix Vladimiriae), Poria, Semen Coicis, Concha Arcae, Limonitum, Pericarpium Citri Reticulatae, Radix Codonopsis and the Rhizoma Atractylodis Macrocephalae are dried, Pulverize 80～120 sieves and soak 10-12 hour；
2) by step 1) in pulverize after Chinese medicine powder by the weight mix homogeneously of prescription of the present invention；Decocting effective component extracting, Pelletize, be vacuum dried (40-50 DEG C), granulate, obtain granule of the present invention.
Embodiment 2: a kind of gastrointestinal contrast agent, according to weight fraction ratio, including:
Cortex Magnoliae Officinalis 6 parts, Rhizoma Cyperi 5 parts, Fructus Aurantii 6 parts, Concha Arcae 16 parts, Limonitum 12 parts, Radix Aucklandiae (Radix Vladimiriae) 5 parts, Poria 8 Part, Semen Coicis 5 parts, Pericarpium Citri Reticulatae 6 parts, Radix Codonopsis 10 parts, the Rhizoma Atractylodis Macrocephalae 6 parts.
The Chinese medicine of weight fraction ratio that will weigh up, preparation method is with embodiment 1.
Embodiment 3: a kind of gastrointestinal contrast agent, according to weight fraction ratio, including:
For obtaining more preferable implementation result, the contrast agent of a kind of gastrointestinal series, according to weight fraction ratio, including: Cortex Magnoliae Officinalis 15 Part, Rhizoma Cyperi 10 parts, Fructus Aurantii 15 parts, Concha Arcae 25 parts, Limonitum 10 parts, Radix Aucklandiae (Radix Vladimiriae) 15 parts, 15 parts of Poria, the heart of a lotus seed Semen Coicis 10 parts, Pericarpium Citri Reticulatae 15 parts, Radix Codonopsis 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.The Chinese medicine of weight fraction ratio that will weigh up, preparation method With embodiment 1.
Embodiment 4: a kind of gastrointestinal contrast agent, according to weight fraction ratio, including:
Cortex Magnoliae Officinalis 12 parts, Rhizoma Cyperi 8 parts, Fructus Aurantii 10 parts, Concha Arcae 15 parts, Limonitum 18 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, Fu Siberian cocklebur 12 parts, Semen Coicis 8 parts, Pericarpium Citri Reticulatae 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.
The Chinese medicine of weight fraction ratio that will weigh up, preparation method is with embodiment 1.
Embodiment 5: contrast agent is used for detecting gastrointestinal disease
5.1, physical data
Outpatient service is chosen to be needed to be the patient that stomach checks, enters totally 100 example of experiment, is randomly divided into two groups, respectively to Chinese medicine Contrast agent group and barium meal contrast medium group, the state of an illness between two groups, men and women, health status are basically identical, without significant difference, have Comparability.
5.2, inspection method
Chinese medicine contrast agent group, according to using method and the dosage of the contrast agent in embodiment 1-3；Previous hour mouth of radiological survey X Take the Chinese medicine granules of the embodiment of the present invention 3 preparation.
Barium meal contrast medium group, detects as contrast agent with the barium sulfate barium meal of guidance amount clinically, and radiological survey X is administered orally for previous hour Barium sulfate.
5.3, result is checked
Good: to have no adverse reaction, radiography is clear, and gastrointestinal is observed clear, and diseased region is observed clear, and image is clear, and point-like is strong Reecho, coat of the stomach clear layer is visible, gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, Substantially, each position focus is high-visible in the imaging such as greater gastric curvature, and contrasting effects is preferable, reaches the purpose diagnosed the illness；
General: or have untoward reaction, or the radiography lack of resolution, radiography is substantially clear, and gastrointestinal is observed the clearest, pathological changes Position is observed the clearest, and image is substantially clear, the stronger reecho of point-like, and coat of the stomach clear layer is visible, gastral cavity size, The imaging such as form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature is more apparent, but it can be seen that basic disease Stove situation.
Poor: radiography obscures, gastrointestinal is observed unclear, and diseased region is observed unclear, and echogenic dots reflection is more weak, coat of the stomach Level is chaotic, and gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature etc. image not clear Aobvious, it can be seen that basic focus and the situation of stomach, existing untoward reaction, again the radiography lack of resolution.
Untoward reaction: allergy, vomiting, painful, appetite is poor, the malaise symptoms that hemorrhage grade causes because of contrast agent.
Chinese medicine contrast agent group, good 48 examples, general 2 examples, poor 0 example；
Barium meal contrast medium group, good 45 examples, general 3 examples, poor 2 examples.
5.4, model case
Case 1: Lee, female 45 years old, Shandong Tancheng people, pharmaceutical factory employee, over 2015, my institute checks, patient's private prosecution stomach for many years Discomfort, flatulence, gastric acid, increases the weight of because of work thing gastropathy sense of discomfort time medical, in the past and systematic do not did detection, the most only It is to take some stomach medicines to alleviate, uses the method radiography of embodiment 3, be administered orally or carry out x-ray double contrast radiograph inspection immediately after coloclysis, Shooting X-ray film, exposed, rinse after carry out testing sheet and diagnosing the state of an illness, the result state of an illness: stomach form is normal, full good, in tiltedly Hook-type, profile finishing, coat of the stomach is soft, and gastric mucosa increases thick, has no and substantially fills scarce and niche, wriggles and empties normal, being diagnosed as Slight gastritis.In checking process, patient gives an oral account stomachache to be had and alleviates, and without sense of discomfort, satiety eliminates.
Case 2: flower certain, man 40 years old, Kunming, Yunnan people, profession, over 2014, my institute checks, main suit prefers to eat peppery Green pepper, but a period of time stomach indigestion recently, ate JIANWEI XIAOSHI PIAN, fast power etc., and effect is not notable, and often has a stomachache, and checks Time the contrast agent of embodiment 1 is administered orally, occur without vomiting situation, radiography is clear, and stomach is fishhook-type, on an empty stomach without stomach pool stream；Gastric antrum glues Film pleat irregular arrangement, increases thick.Coat of the stomach wriggling is poor, and pyloric cap form is normal, and tentative diagnosis is acute gastritis, In checking process, patient gives an oral account stomachache to be had and alleviates, and without sense of discomfort, satiety eliminates.
Case 3: the Qin, female 32 years old, Linshu, Shandong, unemployed, the regular pain of patient's private prosecution the intestines and stomach, do canel barium meal contrast examination at the beginning, Being difficult to swallow, and 1 hour barium meal has arrived ileocecus, fail smooth radiography, main suit is difficult to swallow.Take the contrast agent of the present invention The contrast agent of embodiment 1 checks, occurs without stomachache, vomiting situation, and radiography is clear, is diagnosed as chronic gastritis, in oral basis Inventive embodiment 4 contrast agent, in checking process, patient does not vomit phenomenon, and oral account burning sensation reduces, and without sense of discomfort.
Embodiment 6: contrast agent is for treating the clinical trial of gastric ulcer
6.1, physical data
Choosing the patient of 100 example gastric ulcers, in age 18-55 year, 43.7 years old mean age, patient is randomly divided into two groups, Being respectively treatment group and matched group, the state of an illness between two groups, health, sex are basically identical, without significant difference, have comparability.
6.2, Therapeutic Method
Treatment group, takes the Chinese medicinal granule of the present invention, 50g on the one, takes at twice, and 10 days is a course for the treatment of, takes continuously 2 courses for the treatment of.
Matched group, takes omeprazole+clarithromycin, within 10 days, is a course for the treatment of, take 2 courses for the treatment of continuously.
6.3, Outcome measure
Cure: stomach dull pain, dull pain, distending pain, burn the stomach pain such as sample pain and disappear, gastric motility recovery, metabolism Recover normal.
Take a turn for the better: stomach discomfort alleviates, and gastric motility has recovered.
Invalid: the state of an illness is not changed in or exacerbation of symptoms.
6.4, therapeutic outcome
Treatment group, cures 20 examples, and take a turn for the better 28 examples, invalid 2 examples.
Matched group, cures 12 examples, and take a turn for the better 22 examples, invalid 16 examples.
6.5, model case
Case 1: grandson, man 35 years old, people from Suqian, Jiangsu, unemployed, patient's private prosecution is regular to have a stomach-ache, and has 3 years medical histories, food It is intended to depressed, distension after meal, is gastric ulcer after diagnosing, by the Drug therapy of the embodiment of the present invention 4, every day twice, each 25g, Granule is taken after mixing it with water, and is careful in one's diet, and after treating two courses for the treatment of, symptom disappears substantially, and stomach pain does not occur, the most somewhat There is flatulence, the phenomenon of belch, continues to have taken two courses for the treatment of, recovery from illness, does not has other uncomfortable reactions in therapeutic process.At mouth Taking embodiments of the invention 4 Drug therapy, in checking process, patient does not vomit phenomenon, and oral account burning sensation reduces, and nothing Sense of discomfort.
Case 2: Zhang, female 41 years old, people from Handan, Hebei, individual, just have a stomach-ache when diet does not notes, 5 years medical histories, dislike The heart, lacks appetite always, is just diagnosed as gastric ulcer before 3 years, was to take omeprazole when having a stomach-ache in the past, and carried out outpatient clinic After, with the Drug therapy of the embodiment of the present invention 4, every day twice, each 25g, granule is taken after mixing it with water, and is careful in one's diet, and treats two After the individual course for the treatment of, appetite improves, and stomach pain does not the most occur, has physogastry once in a while, continues to have taken two courses for the treatment of, Recovery from illness, does not has other uncomfortable reactions in therapeutic process.In oral embodiments of the invention 4 Drug therapy, in checking process, Patient does not vomit phenomenon, and oral account burning sensation reduces, and without sense of discomfort.

Claims (8)

1. a gastrointestinal contrast agent, it is characterised in that according to weight fraction ratio, including: Cortex Magnoliae Officinalis 5-15 part, Rhizoma Cyperi 5-10 part, Fructus Aurantii 6-15 part, Concha Arcae 15-25 part, Limonitum 10-20 part, Radix Aucklandiae (Radix Vladimiriae) 5-15 part, Poria 8-15 part, Semen Coicis 5-10 part, Pericarpium Citri Reticulatae 5-15 part, Radix Codonopsis 10-20 part, Rhizoma Atractylodis Macrocephalae 5-10 part.
A kind of gastrointestinal contrast agent, it is characterised in that according to weight fraction ratio, including: Cortex Magnoliae Officinalis 10 parts, Rhizoma Cyperi 8 parts, Fructus Aurantii 10 parts, Concha Arcae 20 parts, Limonitum 15 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, 12 parts of Poria, Semen Coicis 8 Part, Pericarpium Citri Reticulatae 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 8 parts.
A kind of gastrointestinal contrast agent, it is characterised in that according to weight fraction ratio, including: Cortex Magnoliae Officinalis 6 parts, Rhizoma Cyperi 5 parts, Fructus Aurantii 6 parts, Concha Arcae 16 parts, Limonitum 12 parts, Radix Aucklandiae (Radix Vladimiriae) 5 parts, 8 parts of Poria, Semen Coicis 5 parts, Pericarpium Citri Reticulatae 6 parts, Radix Codonopsis 10 parts, the Rhizoma Atractylodis Macrocephalae 6 parts.
A kind of gastrointestinal contrast agent, it is characterised in that according to weight fraction ratio, including: Cortex Magnoliae Officinalis 15 parts, Rhizoma Cyperi 10 parts, Fructus Aurantii 15 parts, Concha Arcae 25 parts, Limonitum 10 parts, Radix Aucklandiae (Radix Vladimiriae) 15 parts, 15 parts of Poria, Semen Coicis 10 parts, Pericarpium Citri Reticulatae 15 parts, Radix Codonopsis 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.
5. the method preparing contrast agent described in claim 1, it is characterised in that concretely comprise the following steps:
1) Cortex Magnoliae Officinalis, Rhizoma Cyperi, Fructus Aurantii, Concha Arcae, Limonitum, Radix Aucklandiae (Radix Vladimiriae), Poria, Semen Coicis, Pericarpium Citri Reticulatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae are dried, Pulverize 80～120 sieves and soak 10-12 hour；
2) by step 1) in pulverize after Chinese medicine powder press the weight mix homogeneously of prescription；Decocting effective component extracting, pelletizes, Vacuum drying, granulate, obtain granule of the present invention.
Contrast agent the most according to claim 1, it is characterised in that described contrast agent answering in preparing gastrointestinal color ultrasound contrast agent With.
Contrast agent the most according to claim 1, it is characterised in that described contrast agent is at preparation prevention and treatment gastrointestinal disease medicine Application in thing.
Contrast agent the most according to claim 7, it is characterised in that described gastrointestinal disease is gastric ulcer, acute gastritis, chronic stomach Inflammation or duodenal ulcer.
CN201610242342.3A 2016-04-19 2016-04-19 Gastrointestinal contrast agent and application thereof Pending CN105727317A (en)

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CN114767812A (en) * 2022-04-27 2022-07-22 泸州市中医医院(泸州市中西医结合医院、泸州市江阳区中医医院) Traditional Chinese medicine composition for strengthening abdomen and preparation method and application thereof

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Application publication date: 20160706