CN104436247A - Contrast agent for detecting gastrointestinal diseases by ultrasonic wave and preparation method thereof - Google Patents
Contrast agent for detecting gastrointestinal diseases by ultrasonic wave and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a contrast agent for detecting gastrointestinal diseases by an ultrasonic wave. The contrast agent is prepared from the following main raw materials in parts by weight: 3-9 parts of bharal horn, 5-15 parts of concha arcae, 4-8 parts of centella, 10-20 parts of medicated leaven, 8-12 parts of cuttle bone, 8-12 parts of potassium iodide, 5-10 parts of tragacanth, 10-20 parts of Arabic gum and 8-16 parts of silicone oil defoaming agent. The contrast agent arrives at or passes through the terminal ileum after being orally taken for 30 minutes, as well as is uniform in distribution in the intestinal tracts, ideal in contrast density value, clear in development, artefact-free, and capable of effectively improving the detection rate of the early lesions of the gastrointestinal tracts and the staging accuracy of the malignant tumours of the gastrointestinal tracts. The contrast agent is an ideal ultrasonic examination oral contrast agent for the gastrointestinal tracts, and suitable for clinical popularization and use.
Description
Technical field
The present invention relates to medical ultrasound diagnosis technical field, particularly relate to and a kind ofly utilize contrast agent of ultrasound detection gastroenteropathy and preparation method thereof.
Background technology
Gastrointestinal disease refers to intestinal mucosa and gastric mucosa inflammation, by multiple priming factors, and can suffer from this disease, there will be multiple symptom, as nausea,vomiting,diarrhea etc., also can have the serious symptoms such as heating, dehydration, answers and early treatment.
Severe gastro-enteritis is maximum to the neonate large less than 18 months harm.The diarrhoea taken place frequently can cause dehydration and certain very important salt to lose, and this can make plysiochemical balance not normal, if do not add prevention, patient may be caused to suffer a shock.Concerning healthy people, vomiting and diarrhoea similarly are only suffered from flu equally several times, do not have too large adverse effect.If but outside vomiting and diarrhoea, also with the stomachache (just sporadic tic) of severe persistent, these symptoms may be just caused by other the celiac disease such as such as appendicitis.
If gastroenteritis is not treated timely, can be unfavorable for healthy, may serious dehydration be caused, pain and infection, become thin, weak, borborygmus, insomnia, dreaminess, to be afraid of cold, severe patient has heatable, palpitates quickly, and weak, anemia, the performances such as electrolyte balance deliberation and malnutrition.Therefore, the gastrointestinal section hospital treatment that gastroenteritis must go specialty was obtained.If think patient not in time diagnosis and treatment cause other gastroenteropathy possibly, even canceration.
Gastrointestinal barium meal examination method is also known as gastric filling method, fill harmonization of the stomach enteric cavity by a kind of contrast agent to eliminate stomach and intestinal intracavity gas to hyperacoustic interference, gastro intestinal ultrasonic environment is improved with this, for a good sound window is built in ultrasonic examination, not only make normal gastric intestinal wall mechanism and pathological changes can clear display, and clearerly distinguish its peripheral organs, contrast agent itself affect penetrating of sound wave again, so the performance of contrast agent directly affects the accuracy of picture quality and diagnosis.
Ultrasonic contrast, also known as acoustic contrast (acoustic contrast), is utilize contrast agent that rear scattered echoes is strengthened, significantly improves the resolving power of ultrasonic diagnosis, the technology of Sensitivity and Specificity.Along with the improvement of instrument performance and the appearance ultrasonic contrast of novel acoustic contrast agent effectively can strengthen two-dimensional ultrasound image and the blood flow doppler signal of the parenchymatous organs such as cardiac muscle, liver, kidney, brain, the blood perfusion situation of reflection and observation normal structure and pathological tissues, has become a very important and up-and-coming developing direction of ultrasonic diagnosis.Someone regards it as the third time revolution after two-dimensional ultrasound, Doppler and color flow angiography as.
In existing gastrointestinal tract contrast medium, application publication number CN 103041410A (application number 201310002201.0) discloses a kind of angiography powder agent for gastrointestinal tract ultrasonic diagnosis, raw material composition and the parts by weight of making described powder effective ingredient are: Radix Glycyrrhizae 70-90 part, Radix Salviae Miltiorrhizae 60-85 part, Rhizoma Pinelliae Preparatum 55-70 part, Concha Haliotidis 50-65 part, Rhizoma Atractylodis Macrocephalae 45-65 part, Cortex Magnoliae Officinalis 45-60 part, Pulvis Talci 40-60 part, Semen Coicis 40-55 part, Massa Medicata Fermentata 35-50 part, Bulbus Fritillariae Uninbracteatae 30-45 part, Os Sepiae 25-40 part, Cornu Cervi Degelatinatum 20-35 part, Radix Bupleuri 14-25 part, stabilizing agent 15 parts, help cathartic 12 parts, 8 parts, iodide.Application publication number CN 103083690A (application number 201310059525.8) discloses a kind of capsule for gastrointestinal color ultrasound contrast: raw material composition and the parts by weight of making described capsule are: Poria 45-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 40-55 part, Concha Haliotidis 35-50 part, Radix Curcumae 30-48 part, Radix Codonopsis 28-45 part, Cortex Magnoliae Officinalis 25-40 part, Pulvis Talci 22-36 part, Concha Ostreae 18-30 part, Fructus Aurantii Immaturus 15-25 part, Bulbus Fritillariae Uninbracteatae 12-22 part, Endoconcha Sepiae 8-18 part, Cornu Cervi Degelatinatum 4-10 part.
In the epoch in medical imaging market, portable ultraphonic has powerful captivation.One of obstruction of ultrasonic development is contrast agent problem.Contrast agent can improve picture quality and diagnosis effect greatly.For some diagnosis, they will be one of key factors helping ultrasonic effective competition MRI, CT.MRI and CT examination can use contrast agent often, but it is little to can be used for ultrasonic contrast agent.Even if in the contrast agent that these are a small amount of, some application are also disputable.U.S. FDA and European medical product assessing mechanism also make warning to applying these contrast agent in some heart diseases.Medical experts are making great efforts to go canvassing and are opposing these ruling.As these market surpervision obstacles are eliminated, produce significant impact by increasing the market of ultrasonic and acoustic contrast agent.
Summary of the invention
For the deficiencies in the prior art; an object of the present invention is to provide a kind of contrast agent utilizing ultrasound detection gastrointestinal disease; image definition, contrast are obviously, rational performance stablizes, and can provide protective effect to gastrointestinal tract simultaneously, are applicable to the conventional and special examination ultrasonic contrast of clinical gastrointestinal tract
Another object of the present invention is just to provide the preparation method of above-mentioned contrast agent.
Technical scheme of the present invention is:
A kind of contrast agent utilizing ultrasound detection gastrointestinal disease, take off the primary raw material stating weight proportion to be prepared from: blue sheep angle 3-9 part, Concha Arcae 5-15 part, Herba Centellae 4-8 part, Massa Medicata Fermentata 10-20 part, Os Sepiae 8-12 part, potassium iodide 8-12 part, tragakanta 5-10 part, arabic gum 10-20 part, silicon oil foam killer 8-16 part.
A kind of contrast agent utilizing ultrasound detection gastrointestinal disease, preferred scheme is, take off the primary raw material stating weight proportion to be prepared from: blue sheep angle 5-7 part, Concha Arcae 8-13 part, Herba Centellae 5-7 part, Massa Medicata Fermentata 13-18 part, Os Sepiae 9-11 part, potassium iodide 9-11 part, tragakanta 7-9 part, arabic gum 13-18 part, silicon oil foam killer 10-14 part.
A kind of contrast agent utilizing ultrasound detection gastrointestinal disease, more preferred scheme is, take off the primary raw material stating weight proportion to be prepared from: 6 parts, blue sheep angle, Concha Arcae 10 parts, Herba Centellae 6 parts, Massa Medicata Fermentata 15 parts, Os Sepiae 10 parts, potassium iodide 10 parts, 8 parts, tragakanta, arabic gum 15 parts, silicon oil foam killer 12 parts.
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) blue sheep angle, Concha Arcae, Os Sepiae are broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizes, and crosses 80-120 mesh sieve;
(2) by Herba Centellae and Massa Medicata Fermentata as in non iron container, the warm water adding 30-40 DEG C soaks 30-50 minute, the consumption of water be the 1-5 of Herba Centellae and Massa Medicata Fermentata consumption doubly, intense fire is fried open, and larding speech with literary allusions decocts 30 minutes, and filter, filtrate is for subsequent use;
(3) step (1) gains are joined in step (2) gained filtrate, mix homogeneously, leave standstill cold preservation 12-24 hour, be concentrated into paste;
(4) by potassium iodide, tragakanta and arabic gum mixing and stirring, be ground to end, cross 100 mesh sieves, for subsequent use;
(5) silicon oil foam killer and step (4) gained mixing smalls are joined stirring and evenly mixing in step (3) gained thick paste, bake drying, dry temperature is 50-80 DEG C, namely obtains radiography granule after cooling.
The above-mentioned preparation method utilizing the contrast agent of ultrasound detection gastrointestinal disease, preferred scheme is: step (1) crosses 90-110 mesh sieve (preferred mistake 100 mesh sieve).
The above-mentioned preparation method utilizing the contrast agent of ultrasound detection gastrointestinal disease, preferred scheme is: step (2) adds the warm water (preferably adding the warm water of 35 DEG C) of 33-38 DEG C.
The above-mentioned preparation method utilizing the contrast agent of ultrasound detection gastrointestinal disease, preferred scheme is: step (2) is soaked 35-45 minute (preferably soaking 40 minutes).
The above-mentioned preparation method utilizing the contrast agent of ultrasound detection gastrointestinal disease, preferred scheme is: the consumption of step (2) water is 2-4 times (preferably 3 times) of Herba Centellae and Massa Medicata Fermentata consumption.
The above-mentioned preparation method utilizing the contrast agent of ultrasound detection gastrointestinal disease, preferred scheme is: step (3) leaves standstill cold preservation 15-20 hour (preferably 18 hours).
The above-mentioned preparation method utilizing the contrast agent of ultrasound detection gastrointestinal disease, preferred scheme is: the temperature of step (5) drying is 60-70 DEG C (preferably 65 DEG C).
Best using method: last hour of ultrasonic examination, oral gained radiography granule 5-15g of the present invention.
The pharmacological effect of each crude drug is respectively:
Blue sheep angle: base is former: be the angle of Bovidae Pseudois animal blue sheep.Composition: blue sheep angle is containing keratin, peptide class, aminoacid, lipid, calcium phosphate, insoluble inorganic salt.The property of medicine: " Inner Mongol medicinal animal ": " bitter in the mouth, cool in nature." function cures mainly: heat-clearing and toxic substances removing.Cure mainly heating, the intestines and stomach abscess, gastroenteritis.Compatibility and incompatibility of drugs: nothing.
Concha Arcae: have another name called Carnis Arca inflata shell, watt room, blood clam skin, row of tiles on a roof clam skin, for Carnis Arca inflata section Carnis Arca inflata belongs to the shell that animal Scapharca subcrenata, Scapharca broughtonii and Tegillarca granosa belong to animal Tegillarca granosa.The property of medicine: matter is hard, sweet in the mouth, salty, property is put down.Composition: main component is calcium carbonate, also containing a small amount of calcium phosphate and magnesium, ferrum, silicate.Find according to modern pharmacological research, this medical instrument has effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for pertinacious phlegm chronic cough, and stomachache acid regurgitation, traumatic hemorrhage, gastric and duodenal ulcers.
Herba Centellae: base is former: be dry herb or the whole herb with root of dicotyledon Umbelliferae Herba Centellae.Composition: containing the Triterpenoid of multiple α-balsam alcohol type, wherein have asiaticoside, thankuniside, isothankuniside, asiaticoside, Brahmoside, broken hot rice glycosides and Brahmic acid etc., and madasiatic acid.The property of medicine: bitter, acrid, cold.Return liver,spleen,kidney warp.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Be the long-lived medicine of Asians, can refresh oneself by beneficial brain.Research shows to have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.Also effective in cure to leprosy, ulcer, there is activation to blood purification and immunity, because it can stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, alleviate mental fatigue; Also can blood pressure lowering, treatment hepatopathy etc.Compatibility and incompatibility of drugs: dosage is crossed conference and caused dizzy.
Massa Medicata Fermentata: sweet in the mouth; Pungent; Warm in nature; Nontoxic.Enter spleen; Stomach warp.Invigorating the spleen and regulating the stomach; Promoting digestion and removing stagnation; Cure mainly retention of food and drink; Dyspepsia; Distension and fullness in the abdomen; Inappetence; Vomiting dysentery." book on Chinese herbal medicine just " carries: " sweet in the mouth gas is put down, spleen invigorating warming the stomach, and removing stagnancy of indigested food and making QI downward, changes in stagnant tune, and by accumulation of phlegm ， Po mass in the abdomen, transporting and transforming nutrients from foodstuff, except the vomiting of cholera distension." modern medicine study confirmation, Massa Medicata Fermentata is containing volume yeast and vitamin B group, and energy appetite stimulator, maintains normal stool function, Ore class medicine can also be helped to digest and assimilate simultaneously.
Os Sepiae: salty in the mouth; Puckery; Warm in nature.Enter liver; Kidney channel.Astringing to arrest bleeding; Treating spontaneous emission and leukorrhagia; Relieving gastric hyperacidity to alleviate stomachache; Removing dampness sore.Cure mainly haematemesis; Hematemesis; Metrorrhagia; Have blood in stool; Epistaxis; Wound hemorrhage; Emission due to deficiency of the kidney spermatorrhea; Leucorrhea with red and white discharge; Have a stomachache noisy; Yuan gas pantothenic acid; Eczema ulcer." Bencao Jingshu " carries: " salty temperature enters Liver and kidney, promoting blood circulation and dispelling cold and dampness, enters liver and gall, Shu Yingqi, temperature and dampness, and the many pus of main skin ulcer also again." modern medicine study confirmation, sepiellae seu sepiae decocting liquid has significant radiation resistance, obviously can promote bone defect healing.
Potassium iodide: be white cubic crystal or powder, micro-in humid air have hygroscopicity, be long placed in and separate out free-iodine and yellowing, and micro iodine hydrochlorate can be formed, light and moist energy accelerated decomposition, potassium iodide is used for manufacturing organic compound and chemical reagent, and potassium iodide is stabilizing agent and cosolvent, and the potassium iodide of feed grade also can cook the supplement as iodine in feed manufacturing.
Tragakanta: for the dry branch of leguminous plant tragakanta tree (Astra-galus gummifer Labill.) is by the natural gum oozed out after hurting, drying and obtaining.Main containing bassorin 8-10%, this composition water soluble.Another containing the sticky element 60% in tragakanta, this composition is water insoluble.[character] is white or yellow-white powder or translucent sheet; Water-swellable becomes toughness jelly.This product viscosity is maximum when pH5, then significantly declines lower than pH4.5 or higher than pH6 viscosity.[effect and purposes] is lubricant, suspending agent, binding agent and floating agent etc.
Arabic gum: arabic gum has complicated molecular structure, mainly includes Arabinose, galactose, glucuronic acid etc.Be a kind of natural plant, take from the tree of a kind of Acacia by name, being condensed by the juice set forms. and the good arabic gum color of quality be amber, and granule is justified greatly, and arabic gum is a kind of carbohydrate polymer, can by Partial digestion in large intestine.It can be human body supplementary fibre element, and compare with maltodextrin with starch, its energy value is less than half.In particular, arabic gum is the mixture of arabogalactan oligosaccharide, polysaccharide and protein sugar.
Silicon oil foam killer: silicon oil foam killer is the complex that dimethicone and defoaming activity agent are combined into by physical chemistry method, processing oily defoamer and aqueous defoamer basic material, compared with dimethicone defoaming and press down bubble property improve, silicon oil foam killer can get rid of the gas in gastrointestinal tract, effectively can eliminate gas and disturb the pseudomorphism produced.
The present invention has no side effect, easy to use, and physicochemical property is stablized, and obviously, image definition, reasonably combined Chinese prescription, avoids the damage of conventional contrast agents to intestinal simultaneously, is applicable to the oral contrast material of the preparation of conventional gastrointestinal road and special examination in contrast.
Accompanying drawing explanation
Fig. 1 takes filling effect after contrast agent of the present invention, video picture situation design sketch.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds utilizes the contrast agent of ultrasound detection gastrointestinal disease, take off the primary raw material stating weight proportion to be prepared from (getting 10g for every part): 3 parts, blue sheep angle, Concha Arcae 5 parts, Herba Centellae 4 parts, Massa Medicata Fermentata 10 parts, Os Sepiae 8 parts, potassium iodide 8 parts, 5 parts, tragakanta, arabic gum 10 parts, silicon oil foam killer 8 parts.
The preparation method of above-mentioned contrast agent, step is as follows:
(1) blue sheep angle, Concha Arcae, Os Sepiae are broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizes, and crosses 80 mesh sieves;
(2) by Herba Centellae and Massa Medicata Fermentata as in non iron container, the warm water adding 30 DEG C soaks 30 minutes, and the consumption of water is 1 times of Herba Centellae and Massa Medicata Fermentata consumption, and intense fire is fried open, and larding speech with literary allusions decocts 30 minutes, and filter, filtrate is for subsequent use;
(3) step (1) gains are joined in step (2) gained filtrate, mix homogeneously, leave standstill cold preservation 12 hours, be concentrated into paste;
(4) by potassium iodide, tragakanta and arabic gum mixing and stirring, be ground to end, cross 100 mesh sieves, for subsequent use;
(5) silicon oil foam killer and step (4) gained mixing smalls are joined stirring and evenly mixing in step (3) gained thick paste, bake drying, dry temperature is 50 DEG C, namely obtains radiography granule after cooling.
Typical case one: Lu XX, man, 45 years old is the workman of Weifang factory, there is the symptom such as diarrhoea, stomachache, Nausea and vomiting, heating, loss of appetite in autumn in 2012, time less than two weeks loses weight (may be the sign of dehydration), and household sees that conditions of patients is more and more serious, just accompanies patient to remove examination in hospital, doctor hear out patient describe symptom after, suggestion patient does ultrasound detection, in ultrasound detection first 1 hour, takes contrast agent 15g of the present invention.
Take the present embodiment 1 gained contrast agent, arrive after 30 minutes or pass through terminal ileum, in intestinal, contrast medium is evenly distributed, and reduced density value is desirable, video picture is clear, without artifact, after ultrasonic examination, determine the state of an illness of patient very soon, and treat in time, patient fully recovers very soon.
Embodiment 2 one kinds utilizes the contrast agent of ultrasound detection gastrointestinal disease, take off the primary raw material stating weight proportion to be prepared from (getting 5g for every part): 9 parts, blue sheep angle, Concha Arcae 15 parts, Herba Centellae 8 parts, Massa Medicata Fermentata 20 parts, Os Sepiae 12 parts, potassium iodide 12 parts, 10 parts, tragakanta, arabic gum 20 parts, silicon oil foam killer 16 parts.
The preparation method of above-mentioned contrast agent, step is as follows:
(1) blue sheep angle, Concha Arcae, Os Sepiae are broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizes, and crosses 120 mesh sieves;
(2) by Herba Centellae and Massa Medicata Fermentata as in non iron container, the warm water adding 40 DEG C soaks 50 minutes, and the consumption of water is 5 times of Herba Centellae and Massa Medicata Fermentata consumption, and intense fire is fried open, and larding speech with literary allusions decocts 30 minutes, and filter, filtrate is for subsequent use;
(3) step (1) gains are joined in step (2) gained filtrate, mix homogeneously, leave standstill cold preservation 24 hours, be concentrated into paste;
(4) by potassium iodide, tragakanta and arabic gum mixing and stirring, be ground to end, cross 100 mesh sieves, for subsequent use;
(5) silicon oil foam killer and step (4) gained mixing smalls are joined stirring and evenly mixing in step (3) gained thick paste, bake drying, dry temperature is 80 DEG C, namely obtains radiography granule after cooling.
Embodiment 3 one kinds utilizes the contrast agent of ultrasound detection gastrointestinal disease, take off the primary raw material stating weight proportion to be prepared from (getting 15g for every part): 5 parts, blue sheep angle, Concha Arcae 8 parts, Herba Centellae 5 parts, Massa Medicata Fermentata 13 parts, Os Sepiae 9 parts, potassium iodide 9 parts, 7 parts, tragakanta, arabic gum 13 parts, silicon oil foam killer 10 parts.
The preparation method of above-mentioned contrast agent, step is as follows:
(1) blue sheep angle, Concha Arcae, Os Sepiae are broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizes, and crosses 90 mesh sieves;
(2) by Herba Centellae and Massa Medicata Fermentata as in non iron container, the warm water adding 33 DEG C soaks 35 minutes, and the consumption of water is 2 times of Herba Centellae and Massa Medicata Fermentata consumption, and intense fire is fried open, and larding speech with literary allusions decocts 30 minutes, and filter, filtrate is for subsequent use;
(3) step (1) gains are joined in step (2) gained filtrate, mix homogeneously, leave standstill cold preservation 15 hours, be concentrated into paste;
(4) by potassium iodide, tragakanta and arabic gum mixing and stirring, be ground to end, cross 100 mesh sieves, for subsequent use;
(5) silicon oil foam killer and step (4) gained mixing smalls are joined stirring and evenly mixing in step (3) gained thick paste, bake drying, dry temperature is 60 DEG C, namely obtains radiography granule after cooling.
Embodiment 4 one kinds utilizes the contrast agent of ultrasound detection gastrointestinal disease, take off the primary raw material stating weight proportion to be prepared from (getting 20g for every part): 7 parts, blue sheep angle, Concha Arcae 13 parts, Herba Centellae 7 parts, Massa Medicata Fermentata 18 parts, Os Sepiae 11 parts, potassium iodide 11 parts, 9 parts, tragakanta, arabic gum 18 parts, silicon oil foam killer 14 parts.
The preparation method of above-mentioned contrast agent, step is as follows:
(1) blue sheep angle, Concha Arcae, Os Sepiae are broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizes, and crosses 110 mesh sieves;
(2) by Herba Centellae and Massa Medicata Fermentata as in non iron container, the warm water adding 38 DEG C soaks 45 minutes, and the consumption of water is 4 times of Herba Centellae and Massa Medicata Fermentata consumption, and intense fire is fried open, and larding speech with literary allusions decocts 30 minutes, and filter, filtrate is for subsequent use;
(3) step (1) gains are joined in step (2) gained filtrate, mix homogeneously, leave standstill cold preservation 20 hours, be concentrated into paste;
(4) by potassium iodide, tragakanta and arabic gum mixing and stirring, be ground to end, cross 100 mesh sieves, for subsequent use;
(5) silicon oil foam killer and step (4) gained mixing smalls are joined stirring and evenly mixing in step (3) gained thick paste, bake drying, dry temperature is 70 DEG C, namely obtains radiography granule after cooling.
Typical case two: king X, female, 52 years old.Weifang, Shandong people from Qingzhou, long-term dry farm work, in June, 2013 starts, the severity of abdominal pain is just felt after having a meal, and dyspepsia, occasionally return acid, burn feeling, the digestive symptoms such as belch, find just shapeless, Mucous Stool, and times of defecation is many, remove examination in hospital, it is abnormal what does not find, just open the medicine of some stomach warming, originally take also effective, but above-mentioned symptom is more and more serious afterwards, sons and daughters see symptom serious consequence all the more, just band king X goes large hospital inspection, doctor says and is difficult to find the etiological cause of the disease at which by superficial phenomenon, suggestion patient adopts ultrasound detection.
Detect first 1 hour and take embodiment 4 gained contrast agent 12g, arrive after 40 minutes or pass through terminal ileum, in intestinal, contrast medium is evenly distributed, and reduced density value is desirable, and video picture is clear, without artifact, after ultrasonic examination, determine the state of an illness of patient very soon, and treat in time, patient fully recovers very soon, takes embodiment 4 gained contrast agent person under inspection in one week, does not occur stomachache, diarrhoea, Nausea and vomiting and General Symptoms.
Embodiment 5 one kinds utilizes the contrast agent of ultrasound detection gastrointestinal disease, take off the primary raw material stating weight proportion to be prepared from (getting 30g for every part): 6 parts, blue sheep angle, Concha Arcae 10 parts, Herba Centellae 6 parts, Massa Medicata Fermentata 15 parts, Os Sepiae 10 parts, potassium iodide 10 parts, 8 parts, tragakanta, arabic gum 15 parts, silicon oil foam killer 12 parts.
The preparation method of above-mentioned contrast agent, step is as follows:
(1) blue sheep angle, Concha Arcae, Os Sepiae are broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizes, and crosses 100 mesh sieves;
(2) by Herba Centellae and Massa Medicata Fermentata as in non iron container, the warm water adding 35 DEG C soaks 40 minutes, and the consumption of water is 3 times of Herba Centellae and Massa Medicata Fermentata consumption, and intense fire is fried open, and larding speech with literary allusions decocts 30 minutes, and filter, filtrate is for subsequent use;
(3) step (1) gains are joined in step (2) gained filtrate, mix homogeneously, leave standstill cold preservation 18 hours, be concentrated into paste;
(4) by potassium iodide, tragakanta and arabic gum mixing and stirring, be ground to end, cross 100 mesh sieves, for subsequent use;
(5) silicon oil foam killer and step (4) gained mixing smalls are joined stirring and evenly mixing in step (3) gained thick paste, bake drying, dry temperature is 65 DEG C, namely obtains radiography granule after cooling.
Test example 1 embodiment 5 gained utilizes the clinical practice of the contrast agent of ultrasound detection gastrointestinal disease: in January ,-2014 in January, 2011, screens 300 routine gastrointestinal disease patients in 4 hospitals, wherein women 150 example, male 150 example.Be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 gained contrast agent, and matched group takes other contrast agent.Using method is: last hour of ultrasonic examination, and oral embodiment 5 gained contrast agent 10g is effective: after taking this product, and filling effect is desirable, and in intestinal, contrast medium is evenly distributed, and reduced density value is desirable, and video picture is clear, without artifact; Invalid: after taking this product, without video picture in intestinal.
1, take medicine in 0-60 minute, observed once every 20 minutes, record filling effect, video picture number, result is as accompanying drawing 1:
Analyze: as can be seen from accompanying drawing 1, contrast agent of the present invention, filling effect, imaging results are substantially identical with other contrast agent classes, in 0-40 minute substantially can video picture clear, without artifact, reach the object of quick display.
2, matched group takes other contrast agent and experimental group takes contrast agent Comparison of therapeutic of the present invention, and result is as shown in table 1:
Table 1
Analyze: as can be seen from Table 1, take contrast agent video picture rate of the present invention up to 97%, cure rate is up to 30%, and successful is better than taking other contrast agent.
Through me institute and clinical gastrointestinal tract ultrasonic examination data tracking discovery, stomachache, diarrhoea, Nausea and vomiting and General Symptoms is there is not in the oral rear person under inspection of contrast agent of the present invention in one week, filling effect is desirable, arrive after oral 30 minutes or pass through terminal ileum, in intestinal, contrast medium is evenly distributed, reduced density value is desirable, video picture is clear, without artifact, effectively can improve the recall rate of gastrointestinal tract early lesion and the accuracy by stages of gastrointestinal cancer, be a kind of desirable gastrointestinal tract ultrasonic examination oral contrast material, be suitable for clinical expansion and use.
Claims (10)
1. one kind utilizes the contrast agent of ultrasound detection gastrointestinal disease, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: blue sheep angle 3-9 part, Concha Arcae 5-15 part, Herba Centellae 4-8 part, Massa Medicata Fermentata 10-20 part, Os Sepiae 8-12 part, potassium iodide 8-12 part, tragakanta 5-10 part, arabic gum 10-20 part, silicon oil foam killer 8-16 part.
2. the contrast agent utilizing ultrasound detection gastrointestinal disease according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: blue sheep angle 5-7 part, Concha Arcae 8-13 part, Herba Centellae 5-7 part, Massa Medicata Fermentata 13-18 part, Os Sepiae 9-11 part, potassium iodide 9-11 part, tragakanta 7-9 part, arabic gum 13-18 part, silicon oil foam killer 10-14 part.
3. the contrast agent utilizing ultrasound detection gastrointestinal disease according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: 6 parts, blue sheep angle, Concha Arcae 10 parts, Herba Centellae 6 parts, Massa Medicata Fermentata 15 parts, Os Sepiae 10 parts, potassium iodide 10 parts, 8 parts, tragakanta, arabic gum 15 parts, silicon oil foam killer 12 parts.
4. the preparation method utilizing the contrast agent of ultrasound detection gastrointestinal disease according to any one of claim 1-3, it is characterized in that, step is as follows:
(1) blue sheep angle, Concha Arcae, Os Sepiae are broken into the block of size as nail cover, put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizes, and crosses 80-120 mesh sieve;
(2) by Herba Centellae and Massa Medicata Fermentata as in non iron container, the warm water adding 30-40 DEG C soaks 30-50 minute, the consumption of water be the 1-5 of Herba Centellae and Massa Medicata Fermentata consumption doubly, intense fire is fried open, and larding speech with literary allusions decocts 30 minutes, and filter, filtrate is for subsequent use;
(3) step (1) gains are joined in step (2) gained filtrate, mix homogeneously, leave standstill cold preservation 12-24 hour, be concentrated into paste;
(4) by potassium iodide, tragakanta and arabic gum mixing and stirring, be ground to end, cross 100 mesh sieves, for subsequent use;
(5) silicon oil foam killer and step (4) gained mixing smalls are joined stirring and evenly mixing in step (3) gained thick paste, bake drying, dry temperature is 50-80 DEG C, namely obtains radiography granule after cooling.
5. preparation method according to claim 4, is characterized in that: step (1) crosses 90-110 mesh sieve (preferred mistake 100 mesh sieve).
6. preparation method according to claim 4, is characterized in that: step (2) adds the warm water (preferably adding the warm water of 35 DEG C) of 33-38 DEG C.
7. preparation method according to claim 4, is characterized in that: step (2) is soaked 35-45 minute (preferably soaking 40 minutes).
8. preparation method according to claim 4, is characterized in that: the consumption of step (2) water is 2-4 times (preferably 3 times) of Herba Centellae and Massa Medicata Fermentata consumption.
9. preparation method according to claim 4, is characterized in that: step (3) leaves standstill cold preservation 15-20 hour (preferably 18 hours).
10. preparation method according to claim 4, is characterized in that: the temperature of step (5) drying is 60-70 DEG C (preferably 65 DEG C).
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740657A (en) * | 2015-04-16 | 2015-07-01 | 张国明 | Gastrointestinal tract developing agent and preparation method thereof |
| CN110314134A (en) * | 2019-01-24 | 2019-10-11 | 北京歌斐医疗器械有限公司 | A kind of gastrointestinal endoscopy auxiliary water and preparation method thereof |
| CN111406838A (en) * | 2020-05-07 | 2020-07-14 | 四川农业大学 | Lick brick for preventing high-precision feed type rumen flatulence of cattle and sheep |
-
2014
- 2014-06-03 CN CN201410238967.3A patent/CN104436247A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740657A (en) * | 2015-04-16 | 2015-07-01 | 张国明 | Gastrointestinal tract developing agent and preparation method thereof |
| CN110314134A (en) * | 2019-01-24 | 2019-10-11 | 北京歌斐医疗器械有限公司 | A kind of gastrointestinal endoscopy auxiliary water and preparation method thereof |
| CN111406838A (en) * | 2020-05-07 | 2020-07-14 | 四川农业大学 | Lick brick for preventing high-precision feed type rumen flatulence of cattle and sheep |
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