CN104740657A - Gastrointestinal tract developing agent and preparation method thereof - Google Patents
Gastrointestinal tract developing agent and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a gastrointestinal tract developing agent. The gastrointestinal tract developing agent is prepared from the main raw materials in parts by weight: 3-5 parts of a silicone oil defoaming agent, 10-20 parts of ligusticum wallichii, 4-12 parts of hericium erinaceus, 1-5 parts of potassium iodide, 1-5 parts of astragalus, 10-20 parts of fragrant-flowered garlic, 5-9 parts of green tea, 3-8 parts of honeysuckles, 1-5 parts of hawthorns, 2-6 parts of lemongrass, 2-6 parts of magnolia obavata, 10-20 parts of mannitol, 6-12 parts of moutan bark, 5-10 parts of cloves and 5-15 parts of radix curcuma. After the developing agent disclosed by the invention is orally taken, the contrast agent distribution in the gastrointestinal tract is uniform, the contrast density value is ideal, the developed images are clear without artifacts, so that the relevance ratio of the early lesion of the gastrointestinal tract and the periodization accuracy of gastrointestinal tract malignant tumors can be effectively improved, and the gastrointestinal tract developing agent is an ideal gastrointestinal tract ultrasonic-testing orally-taken developing agent and is suitable for clinical popularization and use.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of gastrointestinal tract contrast medium and preparation method.
Background technology
Gastrointestinal disease refers to intestinal mucosa and gastric mucosa inflammation, by multiple priming factors, and can suffer from this disease, there will be multiple symptom, as nausea,vomiting,diarrhea etc., also can have the serious symptoms such as heating, dehydration, answers and early treatment.
Severe gastro-enteritis is maximum to the neonate large less than 18 months harm.The diarrhoea taken place frequently can cause dehydration and certain very important salt to lose, and this can make plysiochemical balance not normal, if do not add prevention, patient may be caused to suffer a shock.Concerning healthy people, vomiting and diarrhoea similarly are only suffered from flu equally several times, do not have too large adverse effect.If but outside vomiting and diarrhoea, also with the stomachache (just sporadic tic) of severe persistent, these symptoms may be just caused by other the celiac disease such as such as appendicitis.
If gastroenteritis is not treated timely, can be unfavorable for healthy, may serious dehydration be caused, pain and infection, become thin, weak, borborygmus, insomnia, dreaminess, to be afraid of cold, severe patient has heatable, palpitates quickly, and weak, anemia, the performances such as electrolyte balance deliberation and malnutrition.Therefore, the gastrointestinal section hospital treatment that gastroenteritis must go specialty was obtained.If think patient not in time diagnosis and treatment cause other gastroenteropathy possibly, even canceration.
Gastrointestinal barium meal examination method is also known as gastric filling method, fill harmonization of the stomach enteric cavity by a kind of contrast agent to eliminate stomach and intestinal intracavity gas to hyperacoustic interference, gastro intestinal ultrasonic environment is improved with this, for a good sound window is built in ultrasonic examination, not only make normal gastric intestinal wall mechanism and pathological changes can clear display, and clearerly distinguish its peripheral organs, contrast agent itself affect penetrating of sound wave again, so the performance of contrast agent directly affects the accuracy of picture quality and diagnosis.
Ultrasonic contrast, also known as acoustic contrast (acoustic contrast), is utilize contrast agent that rear scattered echoes is strengthened, significantly improves the resolving power of ultrasonic diagnosis, the technology of Sensitivity and Specificity.Along with the improvement of instrument performance and the appearance ultrasonic contrast of novel acoustic contrast agent effectively can strengthen two-dimensional ultrasound image and the blood flow doppler signal of the parenchymatous organs such as cardiac muscle, liver, kidney, brain, the blood perfusion situation of reflection and observation normal structure and pathological tissues, has become a very important and up-and-coming developing direction of ultrasonic diagnosis.Someone regards it as the third time revolution after two-dimensional ultrasound, Doppler and color flow angiography as.
In existing gastrointestinal tract contrast medium, application publication number CN 103041410 A (application number 201310002201.0) discloses a kind of angiography powder agent for gastrointestinal tract ultrasonic diagnosis, raw material composition and the parts by weight of making described powder effective ingredient are: Radix Glycyrrhizae 70-90 part, Radix Salviae Miltiorrhizae 60-85 part, Rhizoma Pinelliae Preparatum 55-70 part, Concha Haliotidis 50-65 part, Rhizoma Atractylodis Macrocephalae 45-65 part, Cortex Magnoliae Officinalis 45-60 part, Pulvis Talci 40-60 part, Semen Coicis 40-55 part, Massa Medicata Fermentata 35-50 part, Bulbus Fritillariae Uninbracteatae 30-45 part, Os Sepiae 25-40 part, Cornu Cervi Degelatinatum 20-35 part, Radix Bupleuri 14-25 part, stabilizing agent 15 parts, help cathartic 12 parts, 8 parts, iodide.Application publication number CN 103083690 A (application number 201310059525.8) discloses a kind of capsule for gastrointestinal color ultrasound contrast: raw material composition and the parts by weight of making described capsule are: Poria 45-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 40-55 part, Concha Haliotidis 35-50 part, Radix Curcumae 30-48 part, Radix Codonopsis 28-45 part, Cortex Magnoliae Officinalis 25-40 part, Pulvis Talci 22-36 part, Concha Ostreae 18-30 part, Fructus Aurantii Immaturus 15-25 part, Bulbus Fritillariae Uninbracteatae 12-22 part, Endoconcha Sepiae 8-18 part, Cornu Cervi Degelatinatum 4-10 part.
In the epoch in medical imaging market, portable ultraphonic has powerful captivation.One of obstruction of ultrasonic development is contrast agent problem.Contrast agent can improve picture quality and diagnosis effect greatly.For some diagnosis, they will be one of key factors helping ultrasonic effective competition MRI, CT.MRI and CT examination can use contrast agent often, but it is little to can be used for ultrasonic contrast agent.Even if in the contrast agent that these are a small amount of, some application are also disputable.U.S. FDA and European medical product assessing mechanism also make warning to applying these contrast agent in some heart diseases.Medical experts are making great efforts to go canvassing and are opposing these ruling.As these market surpervision obstacles are eliminated, produce significant impact by increasing the market of ultrasonic and acoustic contrast agent.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of gastrointestinal contrast agent, have and control headache, dizzy effect, medical material medicine source of the present invention is easy to get, with low cost, selected medical material mostly be mild in medicine property and thing, convenient nursing personnel treat the patient that heatstroke is fainted, and effect is lasting, does not have irritant abnormal smells from the patient, to human body without any injury.
Another object of the present invention is just to provide the preparation method of above-mentioned contrast agent.
Technical scheme of the present invention is:
A kind of gastrointestinal tract contrast medium, takes off the primary raw material stating weight proportion and is prepared from:
A kind of gastrointestinal tract contrast medium, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from:
A kind of gastrointestinal tract contrast medium, more preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from:
The preparation method of above-mentioned contrast agent, step is as follows:
(1) Rhizoma Chuanxiong, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali, Flos Caryophylli and Rhizoma Curcumae Longae are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 3-7 days, filter, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1-2 hour, volatile oil and water are together distilled, collect distillate, leave standstill 50-70 minute, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by:
(2) by even to Folium Allii tuberosi, green tea, Herba Cymbopogonis Citrari and the spray of Cortex Magnoliae Officinalis yellow wine, be placed on tile, little fire dries 10-20 minute slowly, cools and grinds to form smalls, crosses 80-120 mesh sieve;
(3) Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 30-40 DEG C, soak 20-40 minute, be heated to boiling, continue to filter after 20-40 minute, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrated solution are mixed, heat after 1-3 minute, put into silicon oil foam killer, potassium iodide and mannitol and fully stir into thick paste; Be placed in container by thick paste and dry 40-60 minute, obtain drying object, dry at temperature is 70-80 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
The preparation method of above-mentioned contrast agent, step (1) sealing is placed in shady and cool ventilation place and leaves standstill 4-6 days (preferred, sealing is placed in shady and cool ventilation place and leaves standstill 5 days).
The preparation method of above-mentioned contrast agent, step (1) filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.3-1.8 hour (preferred, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.5 hours).
The preparation method of above-mentioned contrast agent, step (2) little fire dries 13-18 minute (preferred, little fire dries 15 minutes slowly) slowly.
The preparation method of above-mentioned contrast agent, Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 33-38 DEG C by step (3), soak 25-35 minute (preferred, Flos Lonicerae, Fructus Crataegi and Cortex Moutan to be added the warm water of 35 DEG C, soak 30 minutes).
The preparation method of above-mentioned contrast agent, step (3) is heated to boiling, continues to filter after 25-35 minute (preferred, to be heated to boiling, to continue to filter after 30 minutes).
The preparation method of above-mentioned contrast agent, thick paste is placed in container by step (4) dries 45-55 minute, obtains drying object, it is dry (preferred at temperature is 73-78 DEG C, thick paste is placed in container and dries 50 minutes, obtain drying object, dry at temperature is 75 DEG C).
Best using method: be the therapeutic effect making the present invention reach best, the contrast agent made, each 40ml, before checking, half an hour takes.
The pharmacological effect of each crude drug is respectively:
Silicon oil foam killer: silicon oil foam killer is the complex that dimethicone and defoaming activity agent are combined into by physical chemistry method, processing oily defoamer and aqueous defoamer basic material, compared with dimethicone defoaming and press down bubble property improve, silicon oil foam killer can get rid of the gas in gastrointestinal tract, effectively can eliminate gas and disturb the pseudomorphism produced.
Rhizoma Chuanxiong: the in vitro tests Rhizoma Chuanxiongs such as antibacterial action have inhibitory action to large intestine, dysentery, distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1: 3) also has inhibitory action to some pathogenic dermatophytes in vitro.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Hericium erinaceus (Bull. Ex Fr.) Pers.: Hericium Evimaccus slice, also claims heriacium tablet.Examination is used for the treatment of gastric cancer, the esophageal carcinoma and gastroduodenal ulcer, chronic gastritis etc. clinically, has certain Palliative curative effect.This product has the pure Chinese medicinal preparation of remarkable curative effect to kind of tumor, the immunologic function of body can be improved, cancerous cell is had to suppression and the killing action of height, total effective rate reaches 91.11%, and Tumor suppression rate of growth reaches 46%-88% and has significant curative effect to hepatocarcinoma, carcinoma of gastric cardia, the esophageal carcinoma, gastric cancer, intestinal cancer, pulmonary carcinoma, nasopharyngeal carcinoma, genito-urinary system cancer etc.
Potassium iodide: be white cubic crystal or powder, micro-in humid air have hygroscopicity, be long placed in and separate out free-iodine and yellowing, and micro iodine hydrochlorate can be formed, light and moist energy accelerated decomposition, potassium iodide is used for manufacturing organic compound and chemical reagent, and potassium iodide is stabilizing agent and cosolvent, and the potassium iodide of feed grade also can cook the supplement as iodine in feed manufacturing.
The Radix Astragali: it has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely, the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, infusing drugs in wine, enter dish etc.
Cortex Moutan: bitter, pungent, is slightly cold, GUIXIN, liver, kidney channel, and have the effects such as clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever, thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, falls and flutter the pain of injury, carbuncle sore tumefacting virus.
Folium Allii tuberosi: leaf, scape and Hua Jun do vegetable and eat; The effects such as seed etc. can be used as medicine, and have the kidney invigorating, and stomach invigorating is refreshed oneself, and hidroschesis is astringent or styptic treatment for spontaneous sweating.In the traditional Chinese medical science, there is people that Folium Allii tuberosi is called " intestinal lavage grass, the kidney invigorating; Warming middle-JIAO to promote flow of QI; Dissipating blood stasis; Removing toxic substances.Main impotence due to deficiency of the kidney; Interior cold is suffered from abdominal pain; Dysphagia and regurgitation; Thoracic obstruction pain; Epistaxis; Spit blood; Hematuria; Dysentery; Hemorrhoid; Carbuncle pyogenic infections from tumour or sore; Dermatitis rhus; Traumatic injury.(1) the kidney invigorating warming YANG: Folium Allii tuberosi is warm in nature, acrid in the mouth, but without tonifying YANG composition.(2) the liver benefiting stomach invigorating: Folium Allii tuberosi contains the special composition such as volatile essential oil and sulfide, gives out a kind of pungent fragrance taste of uniqueness, contributes to dredging adjusting irritability, appetite stimulator, strengthens digestive function.(3) circulation of qi promoting treating blood disorders: the acrid odors of Folium Allii tuberosi has removing blood stasis and activating blood flow, the effect of circulation of qi promoting intestinal stasis relieving, is applicable to the diseases such as traumatic injury, regurgitation, enteritis, haematemesis, chest pain.(4) loosening bowel to relieve constipation: Folium Allii tuberosi contains a large amount of vitamin and crude fibre, can promote gastrointestinal peristalsis, treatment constipation, prevention intestinal cancer.
Green tea: green tea is that remain the natural materials of fresh leaf, the tea polyphenols contained, catechin, chlorophyll, caffeine, aminoacid, vitamins and other nutritious components are also more without the tea made that ferments.These natural nutrition compositions in green tea have special-effect to anti-aging, anti-cancer, anticancer, sterilization, antiinflammatory etc., are less than other teas.Green tea is with suitable And Development of Tea Shoot for raw material, through completing, kneading, the Folium Camelliae sinensis made of the typical process process such as dry.Be homophony with green at the bottom of its dry dark brown pool and the millet paste after brewing, leaf, therefore named green tea.Green tea be the fresh leaf that will pluck first through green removing in high temperature, killed various oxidase, maintained Folium Camelliae sinensis green, then through kneading, dry and make, clear soup greenery are common features of green tea quality.Folium Camelliae sinensis not only have refresh oneself clear away heart-fire, clearing away summer-heat, eliminate indigestion and phlegm, go greasy fat-reducing, the relieving restlessness that clears away heart-fire, the pharmacological action such as removing toxic substances relieving alcoholic intoxication, promoting the production of body fluid to quench thirst, pathogenic fire reducing improving eyesight, dysentery relieving dehumidifying, also to modern diseases, as diseases such as Radiation sickness, cardiovascular and cerebrovascular disease, cancers, there is certain pharmacological effect.The Main Ingredients and Appearance that Folium Camelliae sinensis has pharmacological action is tea polyphenols, caffeine, lipopolysaccharide, theanine etc.
Flos Lonicerae: its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Fructus Crataegi: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
Herba Cymbopogonis Citrari: for contracting wine, offer a sacrifice to gods or ancestors world ancestors, the Chu Guozhu Zhou Dynasty wraps Mao Zhigong, offers give all emperors with Herba Cymbopogonis Citrari.Utilize part: blade is main, refinement quintessence oil then sheath also can utilize.Herba Cymbopogonis Citrari grows at semi-tropical a kind of Rhizoma Imperatae spice, natural in citrus scented, has effect that stomach function regulating is ventilated, refreshment is promoted the sexual maturity.
Flos Caryophylli: return spleen, stomach, lung, kidney channel.Function: have warming middle-JIAO to send down the adverse QI, effect of reinforcing the kidney and supporting YANG.Cure mainly editor for Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Cortex Magnoliae Officinalis: can the sense of taste be stimulated to gastrointestinal effect Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof, reflexively cause saliva, gastric secretion, gastrointestinal peristalsis is accelerated, and have stomach invigorating digestion-aid effect, the checking of resisting pathogenic microbes acting body exterior-excess is bright, Cortex Magnoliae Officinalis decoct is to staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, the gram positive bacterias such as bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, the gram negative bacillis such as bacillus subtilis all have antibacterial action. and experiment shows, compare with other 61 kinds of Chinese medicines, Cortex Magnoliae Officinalis is to Staphylococcus albus, bacillus subtilis, the effect of escherichia coli and Bacillus typhi is the strongest. and it act as bactericidal action to Staphylococcus albus and bacillus subtilis, in vitro, Cortex Magnoliae Officinalis is to the inhibitory action of staphylococcus aureus comparatively Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei is strong, when decoct (1: 1) is diluted to 1/640, its bacteriostasis is still better than chlortetracycline. and the antibacterial action of decoct does not destroy because of heating.
Mannitol: mannitol is being pharmaceutically good diuretic, reduces the diluent of intracranial pressure, intraocular pressure and treatment kidney medicine, dehydrant, sugar succedaneum, the excipient being also used as tablet and solid, liquid.
Formula mannitol injection liquid (Injectio Mannitou) oozes depressor as height, is clinical rescue a kind of medicine that particularly brain disorder rescue is conventional, has the fast curative effect of the blood pressure lowering feature accurately reduced required by intracranial pressure medicine.Mannitol enters after in body can improve plasma osmotic pressure, make tissue dewatering, intracranial pressure and intraocular pressure can be reduced, after glomerular filtration, not easily heavily absorbed by ball on kidney, osmotic pressure of urine is increased, take a large amount of moisture content out of and dewater, for the edema that craniocerebral trauma, cerebroma, cerebral hypoxia cause, the edema caused after large-area burns, the ascites glaucoma that renal failure causes.And early stage acute renal insufficiency can be prevented and treated.As tablet excipients, mannitol no hygroscopicity, fast drying, chemical stability is good, and has the features such as tasty and refreshing, pelletize is good, for most of tablets such as anticarcinogen, antimicrobial drug, antihistaminic and vitamin.In addition, also for chewing tablets such as fresheners in hangover medicine, mouth.Though mannitol can absorb by the gastrointestinal of people, do not accumulate in vivo.After absorbing, a part is in vivo by metabolism, and another part is discharged from urine; When mannitol is because dissolving, heat absorption, pleasantly sweet, has comfort sense to oral cavity, therefore be more widely used in the manufacture of the chewable tablet such as freshener in hangover medicine, mouth, and its granular pattern specially makes the excipient of direct compression.
Rhizoma Curcumae Longae: removing blood stasis circulation of qi promoting, relieving pain of dysmenorrhea.Cure mainly for the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, dysmenorrhea amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.
The present invention has no side effect, easy to use, and physicochemical property is stablized, and obviously, image definition, reasonably combined Chinese prescription, avoids the damage of conventional contrast agents to intestinal simultaneously, is applicable to the oral contrast material of the preparation of conventional gastrointestinal road and special examination in contrast.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds of gastrointestinal contrast agent, take off the primary raw material stating weight proportion and are prepared from (getting 10g for every part):
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Rhizoma Chuanxiong, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali, Flos Caryophylli and Rhizoma Curcumae Longae are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 3 days, filter, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1 hour, volatile oil and water are together distilled, collect distillate, leave standstill 50 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) by even to Folium Allii tuberosi, green tea, Herba Cymbopogonis Citrari and the spray of Cortex Magnoliae Officinalis yellow wine, be placed on tile, little fire dries 10-20 minute slowly, cools and grinds to form smalls, crosses 80 mesh sieves;
(3) Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 30 DEG C, soak 20 minutes, be heated to boiling, continue to filter after 20 minutes, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrated solution are mixed, heat after 1 minute, put into silicon oil foam killer, potassium iodide and mannitol and fully stir into thick paste; Be placed in by thick paste in container and dry 40 minutes, obtain drying object, dry at temperature is 70 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
Typical case one: Zou X, female, 58 years old.Jinan, Shandong Province goes through lower personage, factory work more than 30 year, in May, 2012 starts, the severity of abdominal pain is just felt after having a meal, and dyspepsia, occasionally return acid, burn feeling, the digestive symptoms such as belch, find just shapeless, Mucous Stool, and times of defecation is many, remove examination in hospital, it is abnormal what does not find, just open the medicine of some stomach warming, originally take also effective, but above-mentioned symptom is more and more serious afterwards, sons and daughters see symptom serious consequence all the more, just band patient goes large hospital inspection, doctor says and is difficult to find the etiological cause of the disease at which by superficial phenomenon, suggestion patient adopts ultrasound detection.
Before detecting, half an hour takes embodiment 1 gained contrast agent, arrive after 20 minutes or pass through terminal ileum, in intestinal, contrast medium is evenly distributed, and reduced density value is desirable, and video picture is clear, without artifact, after ultrasonic examination, determine the state of an illness of patient very soon, and treat in time, patient fully recovers very soon, takes embodiment 1 gained contrast agent person under inspection in one week, does not occur stomachache, diarrhoea, Nausea and vomiting and General Symptoms.
Embodiment 2 one kinds of gastrointestinal contrast agent, take off the primary raw material stating weight proportion and are prepared from (getting 5g for every part):
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Rhizoma Chuanxiong, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali, Flos Caryophylli and Rhizoma Curcumae Longae are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 7 days, filter, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 2 hours, volatile oil and water are together distilled, collect distillate, leave standstill 70 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) by even to Folium Allii tuberosi, green tea, Herba Cymbopogonis Citrari and the spray of Cortex Magnoliae Officinalis yellow wine, be placed on tile, little fire dries 20 minutes slowly, cools and grinds to form smalls, crosses 120 mesh sieves;
(3) Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 40 DEG C, soak 40 minutes, be heated to boiling, continue to filter after 40 minutes, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrated solution are mixed, heat after 3 minutes, put into silicon oil foam killer, potassium iodide and mannitol and fully stir into thick paste; Be placed in by thick paste in container and dry 60 minutes, obtain drying object, dry at temperature is 80 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
Embodiment 3 one kinds of gastrointestinal contrast agent, take off the primary raw material stating weight proportion and are prepared from (getting 15g for every part):
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Rhizoma Chuanxiong, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali, Flos Caryophylli and Rhizoma Curcumae Longae are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 4 days, filter, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.3 hours, volatile oil and water are together distilled, collect distillate, leave standstill 55 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) by even to Folium Allii tuberosi, green tea, Herba Cymbopogonis Citrari and the spray of Cortex Magnoliae Officinalis yellow wine, be placed on tile, little fire dries 13 minutes slowly, cools and grinds to form smalls, crosses 90 mesh sieves;
(3) Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 33 DEG C, soak 25 minutes, be heated to boiling, continue to filter after 25 minutes, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrated solution are mixed, heat after 1 minute, put into silicon oil foam killer, potassium iodide and mannitol and fully stir into thick paste; Be placed in by thick paste in container and dry 45 minutes, obtain drying object, dry at temperature is 73 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
Typical case two: field XX, man, 48 years old is the workman of Jinan factory, there is the symptom such as diarrhoea, stomachache, Nausea and vomiting, heating, loss of appetite in autumn in 2013, time less than two weeks loses weight (may be the sign of dehydration), and household sees that conditions of patients is more and more serious, just accompanies patient to remove examination in hospital, doctor hear out patient describe symptom after, suggestion patient does ultrasound detection, half an hour before ultrasound detection, takes contrast agent of the present invention.
Take the present embodiment 1 gained contrast agent, arrive after 25 minutes or pass through terminal ileum, in intestinal, contrast medium is evenly distributed, and reduced density value is desirable, video picture is clear, without artifact, after ultrasonic examination, determine the state of an illness of patient very soon, and treat in time, patient fully recovers very soon.
Embodiment 4 one kinds of gastrointestinal contrast agent, take off the primary raw material stating weight proportion and are prepared from (getting 20g for every part):
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Rhizoma Chuanxiong, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali, Flos Caryophylli and Rhizoma Curcumae Longae are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 6 days, filter, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.8 hours, volatile oil and water are together distilled, collect distillate, leave standstill 65 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) by even to Folium Allii tuberosi, green tea, Herba Cymbopogonis Citrari and the spray of Cortex Magnoliae Officinalis yellow wine, be placed on tile, little fire dries 18 minutes slowly, cools and grinds to form smalls, crosses 110 mesh sieves;
(3) Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 38 DEG C, soak 35 minutes, be heated to boiling, continue to filter after 35 minutes, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrated solution are mixed, heat after 3 minutes, put into silicon oil foam killer, potassium iodide and mannitol and fully stir into thick paste; Be placed in by thick paste in container and dry 55 minutes, obtain drying object, dry at temperature is 78 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
Embodiment 5 one kinds of gastrointestinal contrast agent, take off the primary raw material stating weight proportion and are prepared from (getting 30g for every part):
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Rhizoma Chuanxiong, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali, Flos Caryophylli and Rhizoma Curcumae Longae are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 5 days, filter, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.5 hours, volatile oil and water are together distilled, collect distillate, leave standstill 60 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) by even to Folium Allii tuberosi, green tea, Herba Cymbopogonis Citrari and the spray of Cortex Magnoliae Officinalis yellow wine, be placed on tile, little fire dries 15 minutes slowly, cools and grinds to form smalls, crosses 100 mesh sieves;
(3) Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 35 DEG C, soak 30 minutes, be heated to boiling, continue to filter after 30 minutes, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrated solution are mixed, heat after 2 minutes, put into silicon oil foam killer, potassium iodide and mannitol and fully stir into thick paste; Be placed in by thick paste in container and dry 50 minutes, obtain drying object, dry at temperature is 75 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
Experimental example 1: the clinical practice of embodiment 5 gained gastrointestinal contrast agent: in January, 2013 in December ,-2014,400 routine patients are screened in 10 hospitals, Continuous Observation is carried out to this crowd before experiment, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group uses embodiment 5 products obtained therefrom, and matched group uses other medicine.Curative effect situation criterion: after taking this product, filling effect is desirable, and in intestinal, contrast medium is evenly distributed, and reduced density value is desirable, and video picture is clear, without artifact; Invalid: after taking this product, without video picture in intestinal.
Result is as shown in table 1.
Table 1: use embodiment 5 gained Chinese medicine decoction compliance test result
Analyze: as can be seen from Table 1, take contrast agent video picture rate of the present invention up to 97%, cure rate is up to 30%, and successful is better than taking other contrast agent.
The foregoing is only preferred embodiment of the present invention; not limit practical range of the present invention with this; those skilled in the art can without prejudice under spirit of the present invention and principle; make different changes and modification, but these change and modify and should be covered by within patent protection category that claims of the present invention defines.
Claims (10)
1. a gastrointestinal tract contrast medium, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
2. gastrointestinal tract contrast medium according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
3. gastrointestinal tract contrast medium according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
4. the preparation method of the gastrointestinal tract contrast medium according to any one of claim 1-3, is characterized in that: step is as follows:
(1) Rhizoma Chuanxiong, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali, Flos Caryophylli and Rhizoma Curcumae Longae are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 3-7 days, filter, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1-2 hour, volatile oil and water are together distilled, collect distillate, leave standstill 50-70 minute, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) by even to Folium Allii tuberosi, green tea, Herba Cymbopogonis Citrari and the spray of Cortex Magnoliae Officinalis yellow wine, be placed on tile, little fire dries 10-20 minute slowly, cools and grinds to form smalls, crosses 80-120 mesh sieve;
(3) Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 30-40 DEG C, soak 20-40 minute, be heated to boiling, continue to filter after 20-40 minute, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrated solution are mixed, heat after 1-3 minute, put into silicon oil foam killer, potassium iodide and mannitol and fully stir into thick paste; Be placed in container by thick paste and dry 40-60 minute, obtain drying object, dry at temperature is 70-80 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
5. the preparation method of contrast agent according to claim 4, is characterized in that: step (1) sealing is placed in shady and cool ventilation place and leaves standstill 4-6 days (preferred, sealing is placed in shady and cool ventilation place and leaves standstill 5 days).
6. the preparation method of contrast agent according to claim 4, it is characterized in that: step (1) filtering residue adds water boiled with high heat, change slow fire and add thermal distillation 1.3-1.8 hour (preferred, filtering residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.5 hours).
7. the preparation method of contrast agent according to claim 4, is characterized in that: step (2) little fire dries 13-18 minute (preferred, little fire dries 15 minutes slowly) slowly.
8. the preparation method of contrast agent according to claim 4, it is characterized in that: Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 33-38 DEG C by step (3), soak 25-35 minute (preferably, Flos Lonicerae, Fructus Crataegi and Cortex Moutan are added the warm water of 35 DEG C, soak 30 minutes).
9. the preparation method of contrast agent according to claim 4, is characterized in that: step (3) is heated to boiling, continues to filter after 25-35 minute (preferred, to be heated to boiling, to continue to filter after 30 minutes).
10. the preparation method of contrast agent according to claim 4, it is characterized in that: thick paste is placed in container by step (4) dries 45-55 minute, obtain drying object, it is dry (preferred at temperature is 73-78 DEG C, thick paste is placed in container and dries 50 minutes, obtain drying object, dry at temperature is 75 DEG C).
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| CN106578199A (en) * | 2016-12-16 | 2017-04-26 | 横琴智库转化医学有限公司 | Oral solution for preventing malignant tumors |
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| CN104189923A (en) * | 2014-09-05 | 2014-12-10 | 李晓光 | Gastrointestinal contrast agent and preparation method thereof |
| CN104436218A (en) * | 2014-12-22 | 2015-03-25 | 徐小琳 | Gastrointestinal contrast agent containing traditional Chinese medicine extract |
| CN104436247A (en) * | 2014-06-03 | 2015-03-25 | 王鹏 | Contrast agent for detecting gastrointestinal diseases by ultrasonic wave and preparation method thereof |
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| CN104436247A (en) * | 2014-06-03 | 2015-03-25 | 王鹏 | Contrast agent for detecting gastrointestinal diseases by ultrasonic wave and preparation method thereof |
| CN104189923A (en) * | 2014-09-05 | 2014-12-10 | 李晓光 | Gastrointestinal contrast agent and preparation method thereof |
| CN104436218A (en) * | 2014-12-22 | 2015-03-25 | 徐小琳 | Gastrointestinal contrast agent containing traditional Chinese medicine extract |
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| CN106578199A (en) * | 2016-12-16 | 2017-04-26 | 横琴智库转化医学有限公司 | Oral solution for preventing malignant tumors |
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Application publication date: 20150701 |